                               SEQUENCE LISTING	

<110> FIVE PRIME THERAPEUTICS, INC.
 
<120> HAIR GROWTH METHODS USING FGFR3 EXTRACELLULAR DOMAINS

<130> 8940-80-304

<140> PCT/US10/61157
<141> 2010-12-17

<150> 61/287,690
<151> 2009-12-17

<160> 57    

<170> PatentIn version 3.5

<210> 1
<211> 784
<212> PRT
<213> Homo sapiens

<400> 1
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala 
            340                 345                 350         


Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe Leu Phe Ile Leu Val Val 
        355                 360                 365             


Ala Ala Val Thr Leu Cys Arg Leu Arg Ser Pro Pro Lys Lys Gly Leu 
    370                 375                 380                 


Gly Ser Pro Thr Val His Lys Ile Ser Arg Phe Pro Leu Lys Arg Gln 
385                 390                 395                 400 


Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr Pro Leu Val 
                405                 410                 415     


Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Thr Leu Ala Asn Val 
            420                 425                 430         


Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Ala 
        435                 440                 445             


Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
    450                 455                 460                 


Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Ala Ala Lys Pro 
465                 470                 475                 480 


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp 
                485                 490                 495     


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
            500                 505                 510         


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro 
        515                 520                 525             


Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe 
    530                 535                 540                 


Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp Tyr Ser Phe Asp Thr Cys 
545                 550                 555                 560 


Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys Asp Leu Val Ser Cys Ala 
                565                 570                 575     


Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
            580                 585                 590         


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val 
        595                 600                 605             


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp 
    610                 615                 620                 


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
625                 630                 635                 640 


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
                645                 650                 655     


Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
            660                 665                 670         


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
        675                 680                 685             


His Arg Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr Met Ile 
    690                 695                 700                 


Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys 
705                 710                 715                 720 


Gln Leu Val Glu Asp Leu Asp Arg Val Leu Thr Val Thr Ser Thr Asp 
                725                 730                 735     


Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu Gln Tyr Ser Pro Gly Gly 
            740                 745                 750         


Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val Phe Ala 
        755                 760                 765             


His Asp Leu Leu Pro Pro Ala Pro Pro Ser Ser Gly Gly Ser Arg Thr 
    770                 775                 780                 


<210> 2
<211> 672
<212> PRT
<213> Homo sapiens

<400> 2
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr Pro Leu Val 
    290                 295                 300                 


Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Thr Leu Ala Asn Val 
305                 310                 315                 320 


Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Ala 
                325                 330                 335     


Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
            340                 345                 350         


Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Ala Ala Lys Pro 
        355                 360                 365             


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp 
    370                 375                 380                 


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
385                 390                 395                 400 


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro 
                405                 410                 415     


Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe 
            420                 425                 430         


Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp Tyr Ser Phe Asp Thr Cys 
        435                 440                 445             


Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys Asp Leu Val Ser Cys Ala 
    450                 455                 460                 


Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
465                 470                 475                 480 


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val 
                485                 490                 495     


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp 
            500                 505                 510         


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
        515                 520                 525             


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
    530                 535                 540                 


Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
545                 550                 555                 560 


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
                565                 570                 575     


His Arg Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr Met Ile 
            580                 585                 590         


Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys 
        595                 600                 605             


Gln Leu Val Glu Asp Leu Asp Arg Val Leu Thr Val Thr Ser Thr Asp 
    610                 615                 620                 


Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu Gln Tyr Ser Pro Gly Gly 
625                 630                 635                 640 


Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val Phe Ala 
                645                 650                 655     


His Asp Leu Leu Pro Pro Ala Pro Pro Ser Ser Gly Gly Ser Arg Thr 
            660                 665                 670         


<210> 3
<211> 786
<212> PRT
<213> Homo sapiens

<400> 3
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Ser Trp Ile Ser Glu Ser Val Glu Ala Asp Val Arg Leu Arg Leu Ala 
    290                 295                 300                 


Asn Val Ser Glu Arg Asp Gly Gly Glu Tyr Leu Cys Arg Ala Thr Asn 
305                 310                 315                 320 


Phe Ile Gly Val Ala Glu Lys Ala Phe Trp Leu Ser Val His Gly Pro 
                325                 330                 335     


Arg Ala Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val 
            340                 345                 350         


Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe Leu Phe Ile Leu 
        355                 360                 365             


Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser Pro Pro Lys Lys 
    370                 375                 380                 


Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg Phe Pro Leu Lys 
385                 390                 395                 400 


Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr Pro 
                405                 410                 415     


Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Thr Leu Ala 
            420                 425                 430         


Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser 
        435                 440                 445             


Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly 
    450                 455                 460                 


Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Ala Ala 
465                 470                 475                 480 


Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp 
                485                 490                 495     


Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile 
            500                 505                 510         


Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly 
        515                 520                 525             


Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg 
    530                 535                 540                 


Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp Tyr Ser Phe Asp 
545                 550                 555                 560 


Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys Asp Leu Val Ser 
                565                 570                 575     


Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys 
            580                 585                 590         


Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp 
        595                 600                 605             


Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn 
    610                 615                 620                 


Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp 
625                 630                 635                 640 


Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp 
                645                 650                 655     


Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly 
            660                 665                 670         


Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys 
        675                 680                 685             


Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr 
    690                 695                 700                 


Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr 
705                 710                 715                 720 


Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu Thr Val Thr Ser 
                725                 730                 735     


Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu Gln Tyr Ser Pro 
            740                 745                 750         


Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val 
        755                 760                 765             


Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser Ser Gly Gly Ser 
    770                 775                 780                 


Arg Thr 
785     


<210> 4
<211> 355
<212> PRT
<213> Homo sapiens

<400> 4
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Ser Trp Ile Ser Glu Ser Val Glu Ala Asp Val Arg Leu Arg Leu Ala 
    290                 295                 300                 


Asn Val Ser Glu Arg Asp Gly Gly Glu Tyr Leu Cys Arg Ala Thr Asn 
305                 310                 315                 320 


Phe Ile Gly Val Ala Glu Lys Ala Phe Trp Leu Ser Val His Gly Pro 
                325                 330                 335     


Arg Ala Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val 
            340                 345                 350         


Tyr Ala Gly 
        355 


<210> 5
<211> 353
<212> PRT
<213> Homo sapiens

<400> 5
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala 
            340                 345                 350         


Gly 
    


<210> 6
<211> 288
<212> PRT
<213> Homo sapiens

<400> 6
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


<210> 7
<211> 587
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Ser Trp Ile Ser Glu Ser Val Glu Ala Asp Val Arg Leu Arg Leu Ala 
    290                 295                 300                 


Asn Val Ser Glu Arg Asp Gly Gly Glu Tyr Leu Cys Arg Ala Thr Asn 
305                 310                 315                 320 


Phe Ile Gly Val Ala Glu Lys Ala Phe Trp Leu Ser Val His Gly Pro 
                325                 330                 335     


Arg Ala Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val 
            340                 345                 350         


Tyr Ala Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
        355                 360                 365             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    370                 375                 380                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
385                 390                 395                 400 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                405                 410                 415     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            420                 425                 430         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        435                 440                 445             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    450                 455                 460                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
465                 470                 475                 480 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                485                 490                 495     


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            500                 505                 510         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        515                 520                 525             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    530                 535                 540                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
545                 550                 555                 560 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                565                 570                 575     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585         


<210> 8
<211> 589
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Ser Trp Ile Ser Glu Ser Val Glu Ala Asp Val Arg Leu Arg Leu Ala 
    290                 295                 300                 


Asn Val Ser Glu Arg Asp Gly Gly Glu Tyr Leu Cys Arg Ala Thr Asn 
305                 310                 315                 320 


Phe Ile Gly Val Ala Glu Lys Ala Phe Trp Leu Ser Val His Gly Pro 
                325                 330                 335     


Arg Ala Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val 
            340                 345                 350         


Tyr Ala Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
        355                 360                 365             


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
    370                 375                 380                 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
385                 390                 395                 400 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                405                 410                 415     


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            420                 425                 430         


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
        435                 440                 445             


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    450                 455                 460                 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
465                 470                 475                 480 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                485                 490                 495     


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
            500                 505                 510         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        515                 520                 525             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
    530                 535                 540                 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
545                 550                 555                 560 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                565                 570                 575     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585                 


<210> 9
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala 
            340                 345                 350         


Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        355                 360                 365             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    370                 375                 380                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
385                 390                 395                 400 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                405                 410                 415     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            420                 425                 430         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        435                 440                 445             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    450                 455                 460                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
465                 470                 475                 480 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                485                 490                 495     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            500                 505                 510         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        515                 520                 525             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    530                 535                 540                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
545                 550                 555                 560 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                565                 570                 575     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585 


<210> 10
<211> 587
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala 
            340                 345                 350         


Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
        355                 360                 365             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    370                 375                 380                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
385                 390                 395                 400 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                405                 410                 415     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            420                 425                 430         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        435                 440                 445             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    450                 455                 460                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
465                 470                 475                 480 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                485                 490                 495     


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            500                 505                 510         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        515                 520                 525             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    530                 535                 540                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
545                 550                 555                 560 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                565                 570                 575     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585         


<210> 11
<211> 581
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Glu Pro Lys 
            340                 345                 350         


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        355                 360                 365             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    370                 375                 380                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
385                 390                 395                 400 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                405                 410                 415     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            420                 425                 430         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        435                 440                 445             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    450                 455                 460                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
465                 470                 475                 480 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                485                 490                 495     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            500                 505                 510         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        515                 520                 525             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    530                 535                 540                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
545                 550                 555                 560 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                565                 570                 575     


Leu Ser Pro Gly Lys 
            580     


<210> 12
<211> 577
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Pro Lys Ser Ser Asp Lys 
            340                 345                 350         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        355                 360                 365             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    370                 375                 380                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
385                 390                 395                 400 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                405                 410                 415     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            420                 425                 430         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        435                 440                 445             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    450                 455                 460                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
465                 470                 475                 480 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
                485                 490                 495     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            500                 505                 510         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        515                 520                 525             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    530                 535                 540                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
545                 550                 555                 560 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 575     


Lys 
    


<210> 13
<211> 576
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Val Glu Ala Glu Pro Lys Ser Ser Asp Lys Thr 
            340                 345                 350         


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        355                 360                 365             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    370                 375                 380                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
385                 390                 395                 400 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                405                 410                 415     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            420                 425                 430         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        435                 440                 445             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    450                 455                 460                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
465                 470                 475                 480 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                485                 490                 495     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            500                 505                 510         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        515                 520                 525             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    530                 535                 540                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
545                 550                 555                 560 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                565                 570                 575     


<210> 14
<211> 572
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            340                 345                 350         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        355                 360                 365             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    370                 375                 380                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
385                 390                 395                 400 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                405                 410                 415     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            420                 425                 430         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        435                 440                 445             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    450                 455                 460                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
465                 470                 475                 480 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                485                 490                 495     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            500                 505                 510         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        515                 520                 525             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    530                 535                 540                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
545                 550                 555                 560 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                565                 570         


<210> 15
<211> 565
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Glu Pro Lys 
                325                 330                 335     


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            340                 345                 350         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        355                 360                 365             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    370                 375                 380                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
385                 390                 395                 400 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                405                 410                 415     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            420                 425                 430         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        435                 440                 445             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    450                 455                 460                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
465                 470                 475                 480 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                485                 490                 495     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            500                 505                 510         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        515                 520                 525             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    530                 535                 540                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
545                 550                 555                 560 


Leu Ser Pro Gly Lys 
                565 


<210> 16
<211> 232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210> 17
<211> 228
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210> 18
<211> 229
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210> 19
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala 
            20      


<210> 20
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala 
            20      


<210> 21
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser 
            20          


<210> 22
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Met Arg Leu Leu Leu Ala Leu Leu Gly Ile Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser 
            20      


<210> 23
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Asp Ala Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu 
1               5                   10                  15      


Asp Thr Gly Val Asp Thr Gly 
            20              


<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Asp Asp Glu Asp Gly Glu Asp 
1               5           


<210> 25
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Asp Asp Glu Asp Gly Glu Asp Glu 
1               5               


<210> 26
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu 
1               5                   10  


<210> 27
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp 
1               5                   10      


<210> 28
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Glu Asp Asp 
            100                 105                 110         


Asp Asp Asp Asp Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala 
            340                 345                 350         


Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        355                 360                 365             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    370                 375                 380                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
385                 390                 395                 400 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                405                 410                 415     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            420                 425                 430         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        435                 440                 445             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    450                 455                 460                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
465                 470                 475                 480 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                485                 490                 495     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            500                 505                 510         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        515                 520                 525             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    530                 535                 540                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
545                 550                 555                 560 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                565                 570                 575     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585 


<210> 29
<211> 375
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu 
        355                 360                 365             


Ala Gly Ser Val Tyr Ala Gly 
    370                 375 


<210> 30
<211> 350
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val 
            340                 345                 350 


<210> 31
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro Cys Leu Ala Pro Ser 
1               5                   10                  15      


Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala Leu Gly Gln Pro Val 
            20                  25                  30          


Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly His Trp Tyr Lys Glu 
        35                  40                  45              


Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg Gly Trp Arg Gly Arg 
    50                  55                  60                  


Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr Leu Cys 
65                  70                  75                  80  


Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn Leu Thr Leu Ile Thr 
                85                  90                  95      


Gly Asp Ala Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser 
            100                 105                 110         


Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Pro Val Ala 
        115                 120                 125             


Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val 
    130                 135                 140                 


Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His Gly Glu 
                165                 170                 175     


Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val 
        195                 200                 205             


Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val Ile Asn 
            260                 265                 270         


Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys 
        275                 280                 285             


Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn 
    290                 295                 300                 


Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser 
305                 310                 315                 320 


Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Glu Pro 
                325                 330                 335     


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            340                 345                 350         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        355                 360                 365             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    370                 375                 380                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
385                 390                 395                 400 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                405                 410                 415     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            420                 425                 430         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        435                 440                 445             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    450                 455                 460                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
465                 470                 475                 480 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                485                 490                 495     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            500                 505                 510         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        515                 520                 525             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    530                 535                 540                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
545                 550                 555                 560 


Ser Leu Ser Pro Gly Lys 
                565     


<210> 32
<211> 587
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu Pro Glu Glu 
1               5                   10                  15      


Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr Val Ala Ala 
            20                  25                  30          


Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp Ala Ala Val 
        35                  40                  45              


Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn Asn Arg Thr 
    50                  55                  60                  


Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr Pro Arg Asp 
65                  70                  75                  80  


Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp Ser Glu Thr 
                85                  90                  95      


Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn 
        115                 120                 125             


Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg 
    130                 135                 140                 


Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala 
145                 150                 155                 160 


Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu 
                165                 170                 175     


Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His 
            180                 185                 190         


Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr 
        195                 200                 205             


Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His 
    210                 215                 220                 


Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly 
225                 230                 235                 240 


Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val 
                245                 250                 255     


Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His 
            260                 265                 270         


Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu 
        275                 280                 285             


Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu 
    290                 295                 300                 


Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr 
305                 310                 315                 320 


Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu 
                325                 330                 335     


Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro 
            340                 345                 350         


Asp Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
        355                 360                 365             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    370                 375                 380                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
385                 390                 395                 400 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                405                 410                 415     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            420                 425                 430         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        435                 440                 445             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    450                 455                 460                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
465                 470                 475                 480 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                485                 490                 495     


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            500                 505                 510         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        515                 520                 525             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    530                 535                 540                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
545                 550                 555                 560 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                565                 570                 575     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585         


<210> 33
<211> 584
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val Gly Ser 
            340                 345                 350         


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        355                 360                 365             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    370                 375                 380                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
385                 390                 395                 400 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                405                 410                 415     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            420                 425                 430         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        435                 440                 445             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    450                 455                 460                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
465                 470                 475                 480 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                485                 490                 495     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            500                 505                 510         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        515                 520                 525             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    530                 535                 540                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
545                 550                 555                 560 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                565                 570                 575     


Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 


<210> 34
<211> 353
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Glu Asp Asp 
            100                 105                 110         


Asp Asp Asp Asp Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala 
            340                 345                 350         


Gly 
    


<210> 35
<211> 582
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Glu Asp Asp 
            100                 105                 110         


Asp Asp Asp Asp Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val Glu Pro 
            340                 345                 350         


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        355                 360                 365             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    370                 375                 380                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
385                 390                 395                 400 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                405                 410                 415     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            420                 425                 430         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        435                 440                 445             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    450                 455                 460                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
465                 470                 475                 480 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                485                 490                 495     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            500                 505                 510         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        515                 520                 525             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    530                 535                 540                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
545                 550                 555                 560 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                565                 570                 575     


Ser Leu Ser Pro Gly Lys 
            580         


<210> 36
<211> 350
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Glu Asp Asp 
            100                 105                 110         


Asp Asp Asp Asp Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val 
            340                 345                 350 


<210> 37
<211> 584
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Glu Asp Asp 
            100                 105                 110         


Asp Asp Asp Asp Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val Gly Ser 
            340                 345                 350         


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        355                 360                 365             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    370                 375                 380                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
385                 390                 395                 400 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                405                 410                 415     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            420                 425                 430         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        435                 440                 445             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    450                 455                 460                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
465                 470                 475                 480 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                485                 490                 495     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            500                 505                 510         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        515                 520                 525             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    530                 535                 540                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
545                 550                 555                 560 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                565                 570                 575     


Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 


<210> 38
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu Asp Pro Lys Ser His Arg 
1               5                   10                  15      


Asp Pro Ser Asn Arg His Ser Tyr Pro Gln Gln 
            20                  25          


<210> 39
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Asp Ala Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser 
1               5                   10                  15      


Ser Glu Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Pro Val 
            20                  25                  30  


<210> 40
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu 
1               5                   10                  15      


Asp Phe Val Ser Glu Asn Ser Asn Asn Lys Arg 
            20                  25          


<210> 41
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Asp Asp Glu Asp Gly Glu 
1               5       


<210> 42
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp 
1               5                   10          


<210> 43
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Asp Asp Glu Asp 
1               


<210> 44
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Val Tyr Ala Gly 
1               


<210> 45
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Glu Ala Gly Ser Val Tyr Ala Gly 
1               5               


<210> 46
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Asp Glu Ala Gly Ser Val Tyr Ala Gly 
1               5                   


<210> 47
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Leu Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala Gly 
1               5                   10              


<210> 48
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser 
1               5                   10                  15      


Val Tyr Ala Gly 
            20  


<210> 49
<211> 23
<212> PRT
<213> Homo sapiens

<400> 49
Leu Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr 
1               5                   10                  15      


Pro Tyr Val Thr Val Leu Lys 
            20              


<210> 50
<211> 90
<212> PRT
<213> Homo sapiens

<400> 50
Leu Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr 
1               5                   10                  15      


Pro Tyr Val Thr Val Leu Lys Ser Trp Ile Ser Glu Ser Val Glu Ala 
            20                  25                  30          


Asp Val Arg Leu Arg Leu Ala Asn Val Ser Glu Arg Asp Gly Gly Glu 
        35                  40                  45              


Tyr Leu Cys Arg Ala Thr Asn Phe Ile Gly Val Ala Glu Lys Ala Phe 
    50                  55                  60                  


Trp Leu Ser Val His Gly Pro Arg Ala Ala Glu Glu Glu Leu Val Glu 
65                  70                  75                  80  


Ala Asp Glu Ala Gly Ser Val Tyr Ala Gly 
                85                  90  


<210> 51
<211> 88
<212> PRT
<213> Homo sapiens

<400> 51
Leu Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr 
1               5                   10                  15      


Pro Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys 
            20                  25                  30          


Glu Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly 
        35                  40                  45              


Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser 
    50                  55                  60                  


Ala Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp 
65                  70                  75                  80  


Glu Ala Gly Ser Val Tyr Ala Gly 
                85              


<210> 52
<211> 89
<212> PRT
<213> Homo sapiens

<400> 52
Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu 
1               5                   10                  15      


Pro Tyr Val Gln Ile Leu Lys His Ser Gly Ile Asn Ser Ser Asp Ala 
            20                  25                  30          


Glu Val Leu Thr Leu Phe Asn Val Thr Glu Ala Gln Ser Gly Glu Tyr 
        35                  40                  45              


Val Cys Lys Val Ser Asn Tyr Ile Gly Glu Ala Asn Gln Ser Ala Trp 
    50                  55                  60                  


Leu Thr Val Thr Arg Pro Val Ala Lys Ala Leu Glu Glu Arg Pro Ala 
65                  70                  75                  80  


Val Met Thr Ser Pro Leu Tyr Leu Glu 
                85                  


<210> 53
<211> 87
<212> PRT
<213> Homo sapiens

<400> 53
Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu 
1               5                   10                  15      


Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp Lys 
            20                  25                  30          


Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala Gly 
        35                  40                  45              


Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His Ser 
    50                  55                  60                  


Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val Met 
65                  70                  75                  80  


Thr Ser Pro Leu Tyr Leu Glu 
                85          


<210> 54
<211> 88
<212> PRT
<213> Homo sapiens

<400> 54
Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu 
1               5                   10                  15      


Pro Tyr Leu Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser Asn Ala 
            20                  25                  30          


Glu Val Leu Ala Leu Phe Asn Val Thr Glu Ala Asp Ala Gly Glu Tyr 
        35                  40                  45              


Ile Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser Ala Trp 
    50                  55                  60                  


Leu Thr Val Leu Pro Lys Gln Gln Ala Pro Gly Arg Glu Lys Glu Ile 
65                  70                  75                  80  


Thr Ala Ser Pro Asp Tyr Leu Glu 
                85              


<210> 55
<211> 87
<212> PRT
<213> Homo sapiens

<400> 55
Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu 
1               5                   10                  15      


Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys 
            20                  25                  30          


Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly 
        35                  40                  45              


Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser 
    50                  55                  60                  


Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr 
65                  70                  75                  80  


Ala Ser Pro Asp Tyr Leu Glu 
                85          


<210> 56
<211> 86
<212> PRT
<213> Homo sapiens

<400> 56
Leu Lys His Ile Val Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe 
1               5                   10                  15      


Pro Tyr Val Gln Val Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val 
            20                  25                  30          


Glu Val Leu Tyr Leu Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr 
        35                  40                  45              


Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp 
    50                  55                  60                  


Leu Thr Val Leu Pro Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro 
65                  70                  75                  80  


Glu Ala Arg Tyr Thr Asp 
                85      


<210> 57
<211> 372
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> SIGNAL
<222> (1)..(22)

<220>
<221> mat_peptide
<222> (23)..(372)

<400> 57
Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
        -20                 -15                 -10             


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
    -5              -1  1               5                   10  


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
                15                  20                  25      


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
            30                  35                  40          


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
        45                  50                  55              


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
    60                  65                  70                  


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
75                  80                  85                  90  


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
                95                  100                 105     


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
            110                 115                 120         


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
        125                 130                 135             


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
    140                 145                 150                 


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
155                 160                 165                 170 


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
                175                 180                 185     


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
            190                 195                 200         


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
        205                 210                 215             


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
    220                 225                 230                 


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
235                 240                 245                 250 


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
                255                 260                 265     


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
            270                 275                 280         


Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu 
        285                 290                 295             


Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu 
    300                 305                 310                 


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala 
315                 320                 325                 330 


Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu 
                335                 340                 345     


Ala Gly Ser Val 
            350 

