                         SEQUENCE LISTING

<110>  VaxInnate Corporation
 
<120>  Methods and Compositions for Providing Protective Immunity in the
        Elderly

<130>  VAX-ELDFLU

<150>  61/292,593
<151>  2010-01-06

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  727
<212>  PRT
<213>  Escherichia coli

<400>  1

Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn Asn 
1               5                   10                  15      


Leu Asn Lys Ser Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu Ser 
            20                  25                  30          


Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln Ala 
        35                  40                  45              


Ile Ala Asn Arg Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala Ser 
    50                  55                  60                  


Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala 
65                  70                  75                  80  


Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala Val 
                85                  90                  95      


Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile Gln 
            100                 105                 110         


Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly Gln 
        115                 120                 125             


Thr Gln Phe Asn Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu Thr 
    130                 135                 140                 


Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu Lys 
145                 150                 155                 160 


Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Ser Leu Asn Val Gln Lys 
                165                 170                 175     


Ala Tyr Asp Val Lys Asp Thr Ala Val Thr Thr Lys Ala Tyr Ala Asn 
            180                 185                 190         


Asn Gly Thr Thr Leu Asp Val Ser Gly Leu Asp Asp Ala Ala Ile Lys 
        195                 200                 205             


Ala Ala Thr Gly Gly Thr Asn Gly Thr Ala Ser Val Thr Gly Gly Ala 
    210                 215                 220                 


Val Lys Phe Asp Ala Asp Asn Asn Lys Tyr Phe Val Thr Ile Gly Gly 
225                 230                 235                 240 


Phe Thr Gly Ala Asp Ala Ala Lys Asn Gly Asp Tyr Glu Val Asn Val 
                245                 250                 255     


Ala Thr Asp Gly Thr Val Thr Leu Ala Ala Gly Ala Thr Lys Thr Thr 
            260                 265                 270         


Met Pro Ala Gly Ala Thr Thr Lys Thr Glu Val Gln Glu Leu Lys Asp 
        275                 280                 285             


Thr Pro Ala Val Val Ser Ala Asp Ala Lys Asn Ala Leu Ile Ala Gly 
    290                 295                 300                 


Gly Val Asp Ala Thr Asp Ala Asn Gly Ala Glu Leu Val Lys Met Ser 
305                 310                 315                 320 


Tyr Thr Asp Lys Asn Gly Lys Thr Ile Glu Gly Gly Tyr Ala Leu Lys 
                325                 330                 335     


Ala Gly Asp Lys Tyr Tyr Ala Ala Asp Tyr Asp Glu Ala Thr Gly Ala 
            340                 345                 350         


Ile Lys Ala Lys Thr Thr Ser Tyr Thr Ala Ala Asp Gly Thr Thr Lys 
        355                 360                 365             


Thr Ala Ala Asn Gln Leu Gly Gly Val Asp Gly Lys Thr Glu Val Val 
    370                 375                 380                 


Thr Ile Asp Gly Lys Thr Tyr Asn Ala Ser Lys Ala Ala Gly His Asp 
385                 390                 395                 400 


Phe Lys Ala Gln Pro Glu Leu Ala Glu Ala Ala Ala Lys Thr Thr Glu 
                405                 410                 415     


Asn Pro Leu Gln Lys Ile Asp Ala Ala Leu Ala Gln Val Asp Ala Leu 
            420                 425                 430         


Arg Ser Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile Thr 
        435                 440                 445             


Asn Leu Gly Asn Thr Val Asn Asn Leu Ser Glu Ala Arg Ser Arg Ile 
    450                 455                 460                 


Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala Gln 
465                 470                 475                 480 


Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val 
                485                 490                 495     


Pro Gln Asn Val Leu Ser Leu Leu Ala Lys Gly Ile Ala Pro Leu Gln 
            500                 505                 510         


Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly Asn Pro Glu Cys 
        515                 520                 525             


Glu Leu Leu Ile Ser Arg Glu Ser Trp Ser Tyr Ile Val Glu Lys Pro 
    530                 535                 540                 


Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly His Phe Ala Asp Tyr Glu 
545                 550                 555                 560 


Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe Glu Arg Phe Glu 
                565                 570                 575     


Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr Thr Thr Gly Val 
            580                 585                 590         


Ser Ala Ser Cys Ser His Asn Gly Glu Ser Ser Phe Tyr Lys Asn Leu 
        595                 600                 605             


Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn Leu Ser Lys Ser 
    610                 615                 620                 


Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu Trp Gly Val His His 
625                 630                 635                 640 


Pro Pro Asn Ile Gly Asp Gln Arg Ala Leu Tyr His Lys Glu Asn Ala 
                645                 650                 655     


Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg Lys Phe Thr Pro Glu 
            660                 665                 670         


Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu Gly Arg Ile Asn Tyr 
        675                 680                 685             


Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile Ile Phe Glu Ala Asn 
    690                 695                 700                 


Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala Leu Ser Arg Gly Phe 
705                 710                 715                 720 


Gly Ser Gly Ile Ile Asn Ser 
                725         


<210>  2
<211>  2193
<212>  DNA
<213>  Escherichia coli

<400>  2
atggcacaag taatcaacac taacagtctg tcgctgctga cccagaataa cctgaacaaa       60

tcccagtccg cactgggcac cgctatcgag cgtctgtctt ctggtctgcg tatcaacagc      120

gcgaaagacg atgcggcagg tcaggcgatt gctaaccgtt tcaccgcgaa catcaaaggt      180

ctgactcagg cttcccgtaa cgctaacgac ggtatctcca ttgcgcagac cactgaaggc      240

gcgctgaacg aaatcaacaa caacctgcag cgtgtgcgtg aactggcggt tcagtctgct      300

aacagcacca actcccagtc tgacctcgac tccatccagg ctgaaatcac ccagcgcctg      360

aacgaaatcg accgtgtatc cggccagact cagttcaacg gcgtgaaagt cctggcgcag      420

gacaacaccc tgaccatcca ggttggcgcc aacgacggtg aaactatcga tatcgatctg      480

aagcagatca actctcagac cctgggtctg gactcactga acgtgcagaa agcgtatgat      540

gtgaaagata cagcagtaac aacgaaagct tatgccaata atggtactac actggatgta      600

tcgggtcttg atgatgcagc tattaaagcg gctacgggtg gtacgaatgg tacggcttct      660

gtaaccggtg gtgcggttaa atttgacgca gataataaca agtactttgt tactattggt      720

ggctttactg gtgctgatgc cgccaaaaat ggcgattatg aagttaacgt tgctactgac      780

ggtacagtaa cccttgcggc tggcgcaact aaaaccacaa tgcctgctgg tgcgacaact      840

aaaacagaag tacaggagtt aaaagataca ccggcagttg tttcagcaga tgctaaaaat      900

gccttaattg ctggcggcgt tgacgctacc gatgctaatg gcgctgagtt ggtcaaaatg      960

tcttataccg ataaaaatgg taagacaatt gaaggcggtt atgcgcttaa agctggcgat     1020

aagtattacg ccgcagatta cgatgaagcg acaggagcaa ttaaagctaa aactacaagt     1080

tatactgctg ctgacggcac taccaaaaca gcggctaacc aactgggtgg cgtagacggt     1140

aaaaccgaag tcgttactat cgacggtaaa acctacaatg ccagcaaagc cgctggtcat     1200

gatttcaaag cacaaccaga gctggcggaa gcagccgcta aaaccaccga aaacccgctg     1260

cagaaaattg atgccgcgct ggcgcaggtg gatgcgctgc gctctgatct gggtgcggta     1320

caaaaccgtt tcaactctgc tatcaccaac ctgggcaata ccgtaaacaa tctgtctgaa     1380

gcgcgtagcc gtatcgaaga ttccgactac gcgaccgaag tttccaacat gtctcgcgcg     1440

cagattctgc agcaggccgg tacttccgtt ctggcgcagg ctaaccaggt cccgcagaac     1500

gtgctgtctc tgttagcgag cggcgtcgca ccgctgcatc tgggtaagtg taacattgct     1560

ggttggattc tgggtaaccc agagtgtgag agcctgtcca ccgcgagcag ctggagctat     1620

atcgtcgaaa ccccgagcag cgacaatggc acctgctatc ctggcgactt cattgattac     1680

gaagaactgc gtgagcaact gagcagcgtg tcgagctttg agcgttttga aatcttcccg     1740

aaaaccagca gctggccgaa tcatgacagc aataagggtg tcacggcagc gtgcccgcac     1800

gctggtgcga aatcctttta caaaaacttg atttggctgg tgaagaaagg caatagctac     1860

ccgaaactgt ctaagtccta catcaatgat aagggtaaag aagttctggt tctgtggggc     1920

atccaccacc cgagcacttc tgcggatcaa caatctctgt accagaacgc cgacgcctac     1980

gttttcgttg gcagctcccg ttacagcaag aaattcaaac cggagattgc gattcgcccg     2040

aaggtccgtg accaggaagg tcgcatgaac tactattgga ccctggtgga gccgggtgat     2100

aagatcacgt ttgaagccac gggtaacttg gtggttccgc gctatgcgtt cgcgatggag     2160

cgtaacgcag gcagcggtat catcatttcg tag                                  2193


<210>  3
<211>  730
<212>  PRT
<213>  Escherichia coli

<400>  3

Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn 
1               5                   10                  15      


Asn Leu Asn Lys Ser Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu 
            20                  25                  30          


Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
        35                  40                  45              


Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala 
    50                  55                  60                  


Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
65                  70                  75                  80  


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala 
                85                  90                  95      


Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile 
            100                 105                 110         


Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly 
        115                 120                 125             


Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu 
    130                 135                 140                 


Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu 
145                 150                 155                 160 


Lys Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Ser Leu Asn Val Gln 
                165                 170                 175     


Lys Ala Tyr Asp Val Lys Asp Thr Ala Val Thr Thr Lys Ala Tyr Ala 
            180                 185                 190         


Asn Asn Gly Thr Thr Leu Asp Val Ser Gly Leu Asp Asp Ala Ala Ile 
        195                 200                 205             


Lys Ala Ala Thr Gly Gly Thr Asn Gly Thr Ala Ser Val Thr Gly Gly 
    210                 215                 220                 


Ala Val Lys Phe Asp Ala Asp Asn Asn Lys Tyr Phe Val Thr Ile Gly 
225                 230                 235                 240 


Gly Phe Thr Gly Ala Asp Ala Ala Lys Asn Gly Asp Tyr Glu Val Asn 
                245                 250                 255     


Val Ala Thr Asp Gly Thr Val Thr Leu Ala Ala Gly Ala Thr Lys Thr 
            260                 265                 270         


Thr Met Pro Ala Gly Ala Thr Thr Lys Thr Glu Val Gln Glu Leu Lys 
        275                 280                 285             


Asp Thr Pro Ala Val Val Ser Ala Asp Ala Lys Asn Ala Leu Ile Ala 
    290                 295                 300                 


Gly Gly Val Asp Ala Thr Asp Ala Asn Gly Ala Glu Leu Val Lys Met 
305                 310                 315                 320 


Ser Tyr Thr Asp Lys Asn Gly Lys Thr Ile Glu Gly Gly Tyr Ala Leu 
                325                 330                 335     


Lys Ala Gly Asp Lys Tyr Tyr Ala Ala Asp Tyr Asp Glu Ala Thr Gly 
            340                 345                 350         


Ala Ile Lys Ala Lys Thr Thr Ser Tyr Thr Ala Ala Asp Gly Thr Thr 
        355                 360                 365             


Lys Thr Ala Ala Asn Gln Leu Gly Gly Val Asp Gly Lys Thr Glu Val 
    370                 375                 380                 


Val Thr Ile Asp Gly Lys Thr Tyr Asn Ala Ser Lys Ala Ala Gly His 
385                 390                 395                 400 


Asp Phe Lys Ala Gln Pro Glu Leu Ala Glu Ala Ala Ala Lys Thr Thr 
                405                 410                 415     


Glu Asn Pro Leu Gln Lys Ile Asp Ala Ala Leu Ala Gln Val Asp Ala 
            420                 425                 430         


Leu Arg Ser Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile 
        435                 440                 445             


Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Ser Glu Ala Arg Ser Arg 
    450                 455                 460                 


Ile Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala 
465                 470                 475                 480 


Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln 
                485                 490                 495     


Val Pro Gln Asn Val Leu Ser Leu Leu Ala Ser Gly Val Ala Pro Leu 
            500                 505                 510         


His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly Asn Pro Glu 
        515                 520                 525             


Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile Val Glu Thr 
    530                 535                 540                 


Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe Ile Asp Tyr 
545                 550                 555                 560 


Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe Glu Arg Phe 
                565                 570                 575     


Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp Ser Asn Lys 
            580                 585                 590         


Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser Phe Tyr Lys 
        595                 600                 605             


Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro Lys Leu Ser 
    610                 615                 620                 


Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val Leu Trp Gly 
625                 630                 635                 640 


Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu Tyr Gln Asn 
                645                 650                 655     


Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser Lys Lys Phe 
            660                 665                 670         


Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln Glu Gly Arg 
        675                 680                 685             


Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys Ile Thr Phe 
    690                 695                 700                 


Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe Ala Met Glu 
705                 710                 715                 720 


Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser 
                725                 730 


<210>  4
<211>  1887
<212>  DNA
<213>  Escherichia coli

<400>  4
atggcacaag taatcaacac taacagtctg tcgctgctga cccagaataa cctgaacaaa       60

tcccagtccg cactgggcac cgctatcgag cgtctgtctt ctggtctgcg tatcaacagc      120

gcgaaagacg atgcggcagg tcaggcgatt gctaaccgtt tcaccgcgaa catcaaaggt      180

ctgactcagg cttcccgtaa cgctaacgac ggtatctcca ttgcgcagac cactgaaggc      240

gcgctgaacg aaatcaacaa caacctgcag cgtgtgcgtg aactggcggt tcagtctgct      300

aacagcacca actcccagtc tgacctcgac tccatccagg ctgaaatcac ccagcgcctg      360

aacgaaatcg accgtgtatc cggccagact cagttcaacg gcgtgaaagt cctggcgcag      420

gacaacaccc tgaccatcca ggttggcgcc aacgacggtg aaactatcga tatcgatctg      480

aagcagatca actctcagac cctgggtctg gactcactga acgtgcagaa agcgtatgat      540

gtgaaagata cagcagtaac aacgaaagct ggcgtcgcac cgctgcatct gggtaagtgt      600

aacattgctg gttggattct gggtaaccca gagtgtgaga gcctgtccac cgcgagcagc      660

tggagctata tcgtcgaaac cccgagcagc gacaatggca cctgctatcc tggcgacttc      720

attgattacg aagaactgcg tgagcaactg agcagcgtgt cgagctttga gcgttttgaa      780

atcttcccga aaaccagcag ctggccgaat catgacagca ataagggtgt cacggcagcg      840

tgcccgcacg ctggtgcgaa atccttttac aaaaacttga tttggctggt gaagaaaggc      900

aatagctacc cgaaactgtc taagtcctac atcaatgata agggtaaaga agttctggtt      960

ctgtggggca tccaccaccc gagcacttct gcggatcaac aatctctgta ccagaacgcc     1020

gacgcctacg ttttcgttgg cagctcccgt tacagcaaga aattcaaacc ggagattgcg     1080

attcgcccga aggtccgtga ccaggaaggt cgcatgaact actattggac cctggtggag     1140

ccgggtgata agatcacgtt tgaagccacg ggtaacttgg tggttccgcg ctatgcgttc     1200

gcgatggagc gtaacgcagg cagcggtatc atcatttcgt cagttgtttc agcagatgct     1260

aaaaatgcct taattgctgg cggcgttgac gctaccgatg ctaatggcgc tgagttggtc     1320

aaaatgtctt ataccgataa aaatggtaag acaattgaag gcggttatgc gcttaaagct     1380

ggcgataagt attacgccgc agattacgat gaagcgacag gagcaattaa agctaaaacc     1440

acaagttata ctgctgctga cggcactacc aaaacagcgg ctaaccaact gggtggcgta     1500

gacggtaaaa ccgaagtcgt tactatcgac ggtaaaacct acaatgccag caaagccgct     1560

ggtcatgatt tcaaagcaca accagagctg gcggaagcag ccgctaaaac caccgaaaac     1620

ccgctgcaga aaattgatgc cgcgctggcg caggtggatg cgctgcgctc tgatctgggt     1680

gcggtacaaa accgtttcaa ctctgctatc accaacctgg gcaataccgt aaacaatctg     1740

tctgaagcgc gtagccgtat cgaagattcc gactacgcga ccgaagtttc caacatgtct     1800

cgcgcgcaga ttttgcagca ggccggtact tccgttctgg cgcaggctaa ccaggtcccg     1860

cagaacgtgc tgagcctgtt acgttag                                         1887


<210>  5
<211>  628
<212>  PRT
<213>  Escherichia coli

<400>  5

Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn 
1               5                   10                  15      


Asn Leu Asn Lys Ser Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu 
            20                  25                  30          


Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
        35                  40                  45              


Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala 
    50                  55                  60                  


Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
65                  70                  75                  80  


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala 
                85                  90                  95      


Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile 
            100                 105                 110         


Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly 
        115                 120                 125             


Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu 
    130                 135                 140                 


Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu 
145                 150                 155                 160 


Lys Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Ser Leu Asn Val Gln 
                165                 170                 175     


Lys Ala Tyr Asp Val Lys Asp Thr Ala Val Thr Thr Lys Ala Gly Val 
            180                 185                 190         


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
        195                 200                 205             


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
    210                 215                 220                 


Val Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
225                 230                 235                 240 


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
                245                 250                 255     


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
            260                 265                 270         


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
        275                 280                 285             


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
    290                 295                 300                 


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
305                 310                 315                 320 


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
                325                 330                 335     


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
            340                 345                 350         


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
        355                 360                 365             


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
    370                 375                 380                 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
385                 390                 395                 400 


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Ser Val Val 
                405                 410                 415     


Ser Ala Asp Ala Lys Asn Ala Leu Ile Ala Gly Gly Val Asp Ala Thr 
            420                 425                 430         


Asp Ala Asn Gly Ala Glu Leu Val Lys Met Ser Tyr Thr Asp Lys Asn 
        435                 440                 445             


Gly Lys Thr Ile Glu Gly Gly Tyr Ala Leu Lys Ala Gly Asp Lys Tyr 
    450                 455                 460                 


Tyr Ala Ala Asp Tyr Asp Glu Ala Thr Gly Ala Ile Lys Ala Lys Thr 
465                 470                 475                 480 


Thr Ser Tyr Thr Ala Ala Asp Gly Thr Thr Lys Thr Ala Ala Asn Gln 
                485                 490                 495     


Leu Gly Gly Val Asp Gly Lys Thr Glu Val Val Thr Ile Asp Gly Lys 
            500                 505                 510         


Thr Tyr Asn Ala Ser Lys Ala Ala Gly His Asp Phe Lys Ala Gln Pro 
        515                 520                 525             


Glu Leu Ala Glu Ala Ala Ala Lys Thr Thr Glu Asn Pro Leu Gln Lys 
    530                 535                 540                 


Ile Asp Ala Ala Leu Ala Gln Val Asp Ala Leu Arg Ser Asp Leu Gly 
545                 550                 555                 560 


Ala Val Gln Asn Arg Phe Asn Ser Ala Ile Thr Asn Leu Gly Asn Thr 
                565                 570                 575     


Val Asn Asn Leu Ser Glu Ala Arg Ser Arg Ile Glu Asp Ser Asp Tyr 
            580                 585                 590         


Ala Thr Glu Val Ser Asn Met Ser Arg Ala Gln Ile Leu Gln Gln Ala 
        595                 600                 605             


Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu 
    610                 615                 620                 


Ser Leu Leu Arg 
625             


<210>  6
<211>  2559
<212>  DNA
<213>  Escherichia coli

<400>  6
atggcacaag taatcaacac taacagtctg tcgctgctga cccagaataa cctgaacaaa       60

tcccagtccg cactgggcac cgctatcgag cgtctgtctt ctggtctgcg tatcaacagc      120

gcgaaagacg atgcggcagg tcaggcgatt gctaaccgtt tcaccgcgaa catcaaaggt      180

ctgactcagg cttcccgtaa cgctaacgac ggtatctcca ttgcgcagac cactgaaggc      240

gcgctgaacg aaatcaacaa caacctgcag cgtgtgcgtg aactggcggt tcagtctgct      300

aacagcacca actcccagtc tgacctcgac tccatccagg ctgaaatcac ccagcgcctg      360

aacgaaatcg accgtgtatc cggccagact cagttcaacg gcgtgaaagt cctggcgcag      420

gacaacaccc tgaccatcca ggttggcgcc aacgacggtg aaactatcga tatcgatctg      480

aagcagatca actctcagac cctgggtctg gactcactga acgtgcagaa agcgtatgat      540

gtgaaagata cagcagtaac aacgaaagct ggcgtcgcac cgctgcatct gggtaagtgt      600

aacattgctg gttggattct gggtaaccca gagtgtgaga gcctgtccac cgcgagcagc      660

tggagctata tcgtcgaaac cccgagcagc gacaatggca cctgctatcc tggcgacttc      720

attgattacg aagaactgcg tgagcaactg agcagcgtgt cgagctttga gcgttttgaa      780

atcttcccga aaaccagcag ctggccgaat catgacagca ataagggtgt cacggcagcg      840

tgcccgcacg ctggtgcgaa atccttttac aaaaacttga tttggctggt gaagaaaggc      900

aatagctacc cgaaactgtc taagtcctac atcaatgata agggtaaaga agttctggtt      960

ctgtggggca tccaccaccc gagcacttct gcggatcaac aatctctgta ccagaacgcc     1020

gacgcctacg ttttcgttgg cagctcccgt tacagcaaga aattcaaacc ggagattgcg     1080

attcgcccga aggtccgtga ccaggaaggt cgcatgaact actattggac cctggtggag     1140

ccgggtgata agatcacgtt tgaagccacg ggtaacttgg tggttccgcg ctatgcgttc     1200

gcgatggagc gtaacgcagg cagcggtatc atcatttcgt cagttgtttc agcagatgct     1260

aaaaatgcct taattgctgg cggcgttgac gctaccgatg ctaatggcgc tgagttggtc     1320

aaaatgtctt ataccgataa aaatggtaag acaattgaag gcggttatgc gcttaaagct     1380

ggcgataagt attacgccgc agattacgat gaagcgacag gagcaattaa agctaaaact     1440

acaagttata ctgctgctga cggcactacc aaaacagcgg ctaaccaact gggtggcgta     1500

gacggtaaaa ccgaagtcgt tactatcgac ggtaaaacct acaatgccag caaagccgct     1560

ggtcatgatt tcaaagcaca accagagctg gcggaagcag ccgctaaaac caccgaaaac     1620

ccgctgcaga aaattgatgc cgcgctggcg caggtggatg cgctgcgctc tgatctgggt     1680

gcggtacaaa accgtttcaa ctctgctatc accaacctgg gcaataccgt aaacaatctg     1740

tctgaagcgc gtagccgtat cgaagattcc gactacgcga ccgaagtttc caacatgtct     1800

cgcgcgcaga ttctgcagca ggccggtact tccgttctgg cgcaggctaa ccaggtcccg     1860

cagaacgtgc tgtctctgtt agcgagcggc gtcgcaccgc tgcatctggg taagtgtaac     1920

attgctggtt ggattctggg taacccagag tgtgagagcc tgtccaccgc gagcagctgg     1980

agctatatcg tcgaaacccc gagcagcgac aatggcacct gctatcctgg cgacttcatt     2040

gattacgaag aactgcgtga gcaactgagc agcgtgtcga gctttgagcg ttttgaaatc     2100

ttcccgaaaa ccagcagctg gccgaatcat gacagcaata agggtgtcac ggcagcgtgc     2160

ccgcacgctg gtgcgaaatc cttttacaaa aacttgattt ggctggtgaa gaaaggcaat     2220

agctacccga aactgtctaa gtcctacatc aatgataagg gtaaagaagt tctggttctg     2280

tggggcatcc accacccgag cacttctgcg gatcaacaat ctctgtacca gaacgccgac     2340

gcctacgttt tcgttggcag ctcccgttac agcaagaaat tcaaaccgga gattgcgatt     2400

cgcccgaagg tccgtgacca ggaaggtcgc atgaactact attggaccct ggtggagccg     2460

ggtgataaga tcacgtttga agccacgggt aacttggtgg ttccgcgcta tgcgttcgcg     2520

atggagcgta acgcaggcag cggtatcatc atttcgtag                            2559


<210>  7
<211>  852
<212>  PRT
<213>  Escherichia coli

<400>  7

Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn 
1               5                   10                  15      


Asn Leu Asn Lys Ser Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu 
            20                  25                  30          


Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
        35                  40                  45              


Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala 
    50                  55                  60                  


Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
65                  70                  75                  80  


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala 
                85                  90                  95      


Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile 
            100                 105                 110         


Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly 
        115                 120                 125             


Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu 
    130                 135                 140                 


Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu 
145                 150                 155                 160 


Lys Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Ser Leu Asn Val Gln 
                165                 170                 175     


Lys Ala Tyr Asp Val Lys Asp Thr Ala Val Thr Thr Lys Ala Gly Val 
            180                 185                 190         


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
        195                 200                 205             


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
    210                 215                 220                 


Val Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
225                 230                 235                 240 


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
                245                 250                 255     


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
            260                 265                 270         


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
        275                 280                 285             


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
    290                 295                 300                 


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
305                 310                 315                 320 


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
                325                 330                 335     


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
            340                 345                 350         


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
        355                 360                 365             


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
    370                 375                 380                 


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
385                 390                 395                 400 


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Ser Val Val 
                405                 410                 415     


Ser Ala Asp Ala Lys Asn Ala Leu Ile Ala Gly Gly Val Asp Ala Thr 
            420                 425                 430         


Asp Ala Asn Gly Ala Glu Leu Val Lys Met Ser Tyr Thr Asp Lys Asn 
        435                 440                 445             


Gly Lys Thr Ile Glu Gly Gly Tyr Ala Leu Lys Ala Gly Asp Lys Tyr 
    450                 455                 460                 


Tyr Ala Ala Asp Tyr Asp Glu Ala Thr Gly Ala Ile Lys Ala Lys Thr 
465                 470                 475                 480 


Thr Ser Tyr Thr Ala Ala Asp Gly Thr Thr Lys Thr Ala Ala Asn Gln 
                485                 490                 495     


Leu Gly Gly Val Asp Gly Lys Thr Glu Val Val Thr Ile Asp Gly Lys 
            500                 505                 510         


Thr Tyr Asn Ala Ser Lys Ala Ala Gly His Asp Phe Lys Ala Gln Pro 
        515                 520                 525             


Glu Leu Ala Glu Ala Ala Ala Lys Thr Thr Glu Asn Pro Leu Gln Lys 
    530                 535                 540                 


Ile Asp Ala Ala Leu Ala Gln Val Asp Ala Leu Arg Ser Asp Leu Gly 
545                 550                 555                 560 


Ala Val Gln Asn Arg Phe Asn Ser Ala Ile Thr Asn Leu Gly Asn Thr 
                565                 570                 575     


Val Asn Asn Leu Ser Glu Ala Arg Ser Arg Ile Glu Asp Ser Asp Tyr 
            580                 585                 590         


Ala Thr Glu Val Ser Asn Met Ser Arg Ala Gln Ile Leu Gln Gln Ala 
        595                 600                 605             


Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu 
    610                 615                 620                 


Ser Leu Leu Ala Ser Gly Val Ala Pro Leu His Leu Gly Lys Cys Asn 
625                 630                 635                 640 


Ile Ala Gly Trp Ile Leu Gly Asn Pro Glu Cys Glu Ser Leu Ser Thr 
                645                 650                 655     


Ala Ser Ser Trp Ser Tyr Ile Val Glu Thr Pro Ser Ser Asp Asn Gly 
            660                 665                 670         


Thr Cys Tyr Pro Gly Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln 
        675                 680                 685             


Leu Ser Ser Val Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Thr 
    690                 695                 700                 


Ser Ser Trp Pro Asn His Asp Ser Asn Lys Gly Val Thr Ala Ala Cys 
705                 710                 715                 720 


Pro His Ala Gly Ala Lys Ser Phe Tyr Lys Asn Leu Ile Trp Leu Val 
                725                 730                 735     


Lys Lys Gly Asn Ser Tyr Pro Lys Leu Ser Lys Ser Tyr Ile Asn Asp 
            740                 745                 750         


Lys Gly Lys Glu Val Leu Val Leu Trp Gly Ile His His Pro Ser Thr 
        755                 760                 765             


Ser Ala Asp Gln Gln Ser Leu Tyr Gln Asn Ala Asp Ala Tyr Val Phe 
    770                 775                 780                 


Val Gly Ser Ser Arg Tyr Ser Lys Lys Phe Lys Pro Glu Ile Ala Ile 
785                 790                 795                 800 


Arg Pro Lys Val Arg Asp Gln Glu Gly Arg Met Asn Tyr Tyr Trp Thr 
                805                 810                 815     


Leu Val Glu Pro Gly Asp Lys Ile Thr Phe Glu Ala Thr Gly Asn Leu 
            820                 825                 830         


Val Val Pro Arg Tyr Ala Phe Ala Met Glu Arg Asn Ala Gly Ser Gly 
        835                 840                 845             


Ile Ile Ile Ser 
    850         


