
                                SEQUENCE LISTING

<110> Emergent Product Development Seattle, LLC
      Blankenship, John W.
      Tan, Philip

<120> POLYPEPTIDE HETERODIMERS AND USES
  THEREOF

<130> 910180.419PC

<140> PCT                 
<141> 2010-12-29  

<150> US 61/366,743       
<151> 2010-07-22  

<160> 889

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1530
<212> DNA
<213> Artificial Sequence

<220> 
<223> Anti-CD28 SMIP (M0039)

<220> 
<221> sig_peptide    
<222> (1)...(66)

<400> 1
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcc 60
agaggagtcc aggtgcagct gaaggagtca ggacctggcc tggtggcgcc ctcacagagc 120
ctgtccatca catgcaccgt ctcagggttc tcattaaccg gctatggtgt aaactgggtt 180
cgccagcctc caggaaaggg tctagagtgg ctgggaatga tatggggtga tggaagcaca 240
gactataatt cagctctcaa atccagacta tcgatcacca aggacaactc caagagccaa 300
gttttcttaa aaatgaacag tctgcaaact gatgacacag ccagatacta ctgtgctcga 360
gatggttata gtaactttca ttactatgtt atggactact ggggtcaagg aacctcagtc 420
accgtctcct ctgggggtgg aggctctggt ggcggtggat ccggcggagg tgggtcgggt 480
ggcggcggat ctgacattgt gctcacccaa tctccagctt ctttggctgt gtctctaggt 540
cagagagcca ccatctcctg cagagccagt gaaagtgttg aatattatgt cacaagttta 600
atgcagtggt accaacagaa accaggacag ccacccaaac tcctcatctc tgctgctagc 660
aacgtagaat ctggggtccc tgccaggttt agtggcagtg ggtctgggac agactttagc 720
ctcaacatcc atcctgtgga ggaggatgat attgcaatgt atttctgtca gcaaagtagg 780
aaggttccat ggacgttcgg tggaggcacc aagctggaaa tcaaacgtga tcaggagccc 840
aaatcttctg acaaaactca cacatcccca ccgtccccag cacctgaact cctgggggga 900
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 960
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 1020
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 1080
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 1140
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aacaatctcc 1200
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 1260
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 1320
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 1380
ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg 1440
cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 1500
cagaagagcc tctccctgtc tccgggtaaa                                  1530

<210> 2
<211> 510
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated M0039

<220> 
<221> SIGNAL         
<222> (1)...(22)

<400> 2
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser
        -20                 -15                 -10             
Val Ile Met Ser Arg Gly Val Gln Val Gln Leu Lys Glu Ser Gly Pro
    -5                   1               5                  10  
Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser
                15                  20                  25      
Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro
            30                  35                  40          
Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr
        45                  50                  55              
Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn
    60                  65                  70                  
Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp
75                  80                  85                  90  
Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr
                95                  100                 105     
Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
            110                 115                 120         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
        125                 130                 135             
Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala
    140                 145                 150                 
Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser
155                 160                 165                 170 
Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro
                175                 180                 185     
Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser
            190                 195                 200         
Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser
        205                 210                 215             
Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys
    220                 225                 230                 
Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
235                 240                 245                 250 
Glu Ile Lys Arg Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr
                255                 260                 265     
Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
            270                 275                 280         
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
        285                 290                 295             
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val
    300                 305                 310                 
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
315                 320                 325                 330 
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
                335                 340                 345     
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
            350                 355                 360         
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
        365                 370                 375             
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
    380                 385                 390                 
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
395                 400                 405                 410 
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
                415                 420                 425     
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
            430                 435                 440         
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
        445                 450                 455             
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
    460                 465                 470                 
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
475                 480                 485             


<210> 3
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide CH1xhonewF

<400> 3
gaaatcaact cgagcgcctc caccaagggc ccatcggtc                        39

<210> 4
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide CH1BsiwnewR

<400> 4
tttgggctcc gtacgaactt tcttgtccac cttggtgttg                       40

<210> 5
<211> 94
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide CH2BsiwnewF

<400> 5
aagaaagttc gtacggagcc caaatcttct gacaaaactc acacatgccc accgtgccca 60
tccggagcac ctgaactcct gggtggaccg tcag                             94

<210> 6
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide CH3NotnewR

<400> 6
gtagacgatg gcggccgcga tatgtagtgg tatcatttac ccggagacag ggagaggc   58

<210> 7
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide 2E12AgeF

<400> 7
ccagatacca ccggtcaggt gcagctgaag gagtcaggac                       40

<210> 8
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide 2E12XhoR

<400> 8
tttgggctcg ctcgagttga tttccagctt ggtgcctcc                        39

<210> 9
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide CkAgeIF

<400> 9
ccagatacca ccggtactgt ggctgcacca tctgtcttc                        39

<210> 10
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide CkBsiWR

<400> 10
tttgggctcc gtacgctctc ccctgttgaa gctctttgtg                       40

<210> 11
<211> 94
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide CH2BsiwnewF

<400> 11
aagaaagttc gtacggagcc caaatcttct gacaaaactc acacatgccc accgtgccca 60
tccggagcac ctgaactcct gggtggaccg tcag                             94

<210> 12
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide CH3NotnewR

<400> 12
gtagacgatg gcggccgcga tatgtagtgg tatcatttac ccggagacag ggagaggc   58

<210> 13
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide CH1xbaF

<400> 13
ccgggtaaat ctagagcctc caccaagggc ccatcggtc                        39

<210> 14
<211> 61
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide CH1NotR

<400> 14
gtagacgatg gcggccgcga tatgtagtgg tatcaaactt tcttgtccac cttggtgttg 60
c                                                                 61

<210> 15
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide CH2xhoF

<400> 15
ctggaaatca actcgagcga gcccaaatct tctgacaaaa ctc                   43

<210> 16
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide CH3xbaR

<400> 16
ggtggaggct ctagatttac ccggagacag ggagaggctc                       40

<210> 17
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide CkXbaF

<400> 17
ccgggtaaat ctagaactgt ggctgcacca tctgtcttc                        39

<210> 18
<211> 61
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide CkNotR

<400> 18
gtagacgatg gcggccgcga tatgtagtgg ttatcactct cccctgttga agctctttgt 60
g                                                                 61

<210> 19
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide CH2AgeF

<400> 19
gagttttgtc agaagatttg ggctccgagg aaccggtggt atctgg                46

<210> 20
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide CH3XbaR

<400> 20
gagcctctcc ctgtctccgg gtaaatctag aactgtggct                       40

<210> 21
<211> 1827
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0112

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 21
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
caggtgcagc tgaaggagtc aggacctggc agcgtggcgc cctcacagag cctgtccatc 120
acatgcaccg tctcagggtt ctcattaacc ggctatggtg taaactgggt tcgccagcct 180
ccaggaaagg gtctggagtg gctgggaatg atatggggtg atggaagcac agactataat 240
tcagctctca aatccagact atcgatcacc aaggacaact ccaagagcca agttttctta 300
aaaatgaaca gtctgcaaac tgatgacaca gccagatact actgtgctcg ggatggttat 360
agtaactttc attactatgt tatggactac tggggtcaag gaacctcagt caccgtctcc 420
tctgggggtg gaggctctgg tggcggtgga tccggcggag gtgggtcggg tggcggcgga 480
tctgacattg tgctcaccca atctccagct tctttggctg tgtctctagg tcagagagcc 540
accatctcct gcagagccag tgaaagtgtt gaatattatg tcacaagttt aatgcagtgg 600
taccaacaga aaccaggaca gccacccaaa ctcctcatct ctgctgctag caacgtagaa 660
tctggggtcc ctgccaggtt tagtggcagt gggtctggga cagactttag cctcaacatc 720
catcctgtgg aggaggatga tattgcaatg tatttctgtc agcaaagtag gaaggttcca 780
tggacgttcg gtggaggcac caagctggaa atcaagtcct cgagcgcctc caccaagggc 840
ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg 900
ggctgcctgg tcaaggacta cttccccgag ccggtgacgg tgtcgtggaa ctcaggcgcc 960
ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc 1020
agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg 1080
aatcacaagc ccagcaacac caaggtggac aagaaagttc gtacggagcc caaatcttct 1140
gacaaaactc acacatgccc accgtgccca tccggagcac ctgaactcct gggtggaccg 1200
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1260
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1320
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 1380
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1440
tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1500
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1560
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatccaag cgacatcgcc 1620
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1680
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1740
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1800
aagagcctct ccctgtctcc gggtaaa                                     1827

<210> 22
<211> 609
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0112

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 22
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Ser Val
                 1               5                  10          
Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser
        15                  20                  25              
Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly
    30                  35                  40                  
Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn
45                  50                  55                  60  
Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser
                65                  70                  75      
Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg
            80                  85                  90          
Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met
        95                  100                 105             
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly
    110                 115                 120                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
125                 130                 135                 140 
Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
                145                 150                 155     
Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr
            160                 165                 170         
Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        175                 180                 185             
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro
    190                 195                 200                 
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile
205                 210                 215                 220 
His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser
                225                 230                 235     
Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            240                 245                 250         
Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
        255                 260                 265             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
    270                 275                 280                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
285                 290                 295                 300 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                305                 310                 315     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
            320                 325                 330         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
        335                 340                 345             
Val Asp Lys Lys Val Arg Thr Glu Pro Lys Ser Ser Asp Lys Thr His
    350                 355                 360                 
Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro
365                 370                 375                 380 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                385                 390                 395     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            400                 405                 410         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        415                 420                 425             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    430                 435                 440                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
445                 450                 455                 460 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                465                 470                 475     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            480                 485                 490         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        495                 500                 505             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    510                 515                 520                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
525                 530                 535                 540 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                545                 550                 555     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            560                 565                 570         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        575                 580                 585             
Lys
    


<210> 23
<211> 1083
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0113

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 23
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 120
actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg 180
aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc 240
aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa 300
cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 360
ttcaacaggg gagagcgtac ggagcccaaa tcttctgaca aaactcacac atgcccaccg 420
tgcccatccg gagcacctga actcctgggt ggaccgtcag tcttcctctt ccccccaaaa 480
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 540
agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 600
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 660
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 720
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 780
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 840
tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag 900
ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 960
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 1020
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 1080
aaa                                                               1083

<210> 24
<211> 361
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 24
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
                 1               5                  10          
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
        15                  20                  25              
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
    30                  35                  40                  
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
45                  50                  55                  60  
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
                65                  70                  75      
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
            80                  85                  90          
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu
        95                  100                 105             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly
    110                 115                 120                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
125                 130                 135                 140 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                145                 150                 155     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            160                 165                 170         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        175                 180                 185             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    190                 195                 200                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
205                 210                 215                 220 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                225                 230                 235     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            240                 245                 250         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        255                 260                 265             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    270                 275                 280                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
285                 290                 295                 300 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                305                 310                 315     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            320                 325                 330         
Lys Ser Leu Ser Leu Ser Pro Gly Lys
        335                 340     


<210> 25
<211> 1827
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0115

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 25
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
caggtgcagc tgaaggagtc aggacctggc agcgtggcgc cctcacagag cctgtccatc 120
acatgcaccg tctcagggtt ctcattaacc ggctatggtg taaactgggt tcgccagcct 180
ccaggaaagg gtctggagtg gctgggaatg atatggggtg atggaagcac agactataat 240
tcagctctca aatccagact atcgatcacc aaggacaact ccaagagcca agttttctta 300
aaaatgaaca gtctgcaaac tgatgacaca gccagatact actgtgctcg ggatggttat 360
agtaactttc attactatgt tatggactac tggggtcaag gaacctcagt caccgtctcc 420
tctgggggtg gaggctctgg tggcggtgga tccggcggag gtgggtcggg tggcggcgga 480
tctgacattg tgctcaccca atctccagct tctttggctg tgtctctagg tcagagagcc 540
accatctcct gcagagccag tgaaagtgtt gaatattatg tcacaagttt aatgcagtgg 600
taccaacaga aaccaggaca gccacccaaa ctcctcatct ctgctgctag caacgtagaa 660
tctggggtcc ctgccaggtt tagtggcagt gggtctggga cagactttag cctcaacatc 720
catcctgtgg aggaggatga tattgcaatg tatttctgtc agcaaagtag gaaggttcca 780
tggacgttcg gtggaggcac caagctggaa atcaagtcct cgagcgagcc caaatcttct 840
gacaaaactc acacatgccc accgtgccca tccggagcac ctgaactcct gggtggaccg 900
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 960
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1020
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 1080
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1140
tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1200
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1260
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatccaag cgacatcgcc 1320
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1380
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1440
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1500
aagagcctct ccctgtctcc gggtaaatct agagcctcca ccaagggccc atcggtcttc 1560
cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc 1620
aaggactact tccccgagcc ggtgacggtg tcgtggaact caggcgccct gaccagcggc 1680
gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg 1740
accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc 1800
agcaacacca aggtggacaa gaaagtt                                     1827

<210> 26
<211> 609
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0115

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 26
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Ser Val
                 1               5                  10          
Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser
        15                  20                  25              
Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly
    30                  35                  40                  
Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn
45                  50                  55                  60  
Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser
                65                  70                  75      
Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg
            80                  85                  90          
Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met
        95                  100                 105             
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly
    110                 115                 120                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
125                 130                 135                 140 
Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
                145                 150                 155     
Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr
            160                 165                 170         
Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        175                 180                 185             
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro
    190                 195                 200                 
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile
205                 210                 215                 220 
His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser
                225                 230                 235     
Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            240                 245                 250         
Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro
        255                 260                 265             
Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
    270                 275                 280                 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
285                 290                 295                 300 
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                305                 310                 315     
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
            320                 325                 330         
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
        335                 340                 345             
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
    350                 355                 360                 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
365                 370                 375                 380 
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
                385                 390                 395     
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
            400                 405                 410         
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
        415                 420                 425             
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
    430                 435                 440                 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
445                 450                 455                 460 
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
                465                 470                 475     
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Ala
            480                 485                 490         
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser
        495                 500                 505             
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
    510                 515                 520                 
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
525                 530                 535                 540 
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
                545                 550                 555     
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
            560                 565                 570         
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys
        575                 580                 585             
Val
    


<210> 27
<211> 1089
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0114

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 27
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
tcctcggagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc atccggagca 120
cctgaactcc tgggtggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc 180
atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct 240
gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg 300
cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag 360
gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc 420
atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg 480
cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc 540
ttctatccaa gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac 600
aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc 660
gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct 720
ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatc tagaactgtg 780
gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc tggaactgcc 840
tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca gtggaaggtg 900
gataacgccc tccaatcggg taactcccag gagagtgtca cagagcagga cagcaaggac 960
agcacctaca gcctcagcag caccctgacg ctgagcaaag cagactacga gaaacacaaa 1020
gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa gagcttcaac 1080
aggggagag                                                         1089

<210> 28
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0114

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 28
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr
                 1               5                  10          
Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro Ser
        15                  20                  25              
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    30                  35                  40                  
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
45                  50                  55                  60  
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                65                  70                  75      
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
            80                  85                  90          
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        95                  100                 105             
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
    110                 115                 120                 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
125                 130                 135                 140 
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
                145                 150                 155     
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            160                 165                 170         
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        175                 180                 185             
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
    190                 195                 200                 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
205                 210                 215                 220 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                225                 230                 235     
Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
            240                 245                 250         
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
        255                 260                 265             
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
    270                 275                 280                 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
285                 290                 295                 300 
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
                305                 310                 315     
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
            320                 325                 330         
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
        335                 340             


<210> 29
<211> 1827
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0116

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 29
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
caggtgcagc tgaaggagtc aggacctggc agcgtggcgc cctcacagag cctgtccatc 120
acatgcaccg tctcagggtt ctcattaacc ggctatggtg taaactgggt tcgccagcct 180
ccaggaaagg gtctggagtg gctgggaatg atatggggtg atggaagcac agactataat 240
tcagctctca aatccagact atcgatcacc aaggacaact ccaagagcca agttttctta 300
aaaatgaaca gtctgcaaac tgatgacaca gccagatact actgtgctcg ggatggttat 360
agtaactttc attactatgt tatggactac tggggtcaag gaacctcagt caccgtctcc 420
tctgggggtg gaggctctgg tggcggtgga tccggcggag gtgggtcggg tggcggcgga 480
tctgacattg tgctcaccca atctccagct tctttggctg tgtctctagg tcagagagcc 540
accatctcct gcagagccag tgaaagtgtt gaatattatg tcacaagttt aatgcagtgg 600
taccaacaga aaccaggaca gccacccaaa ctcctcatct ctgctgctag caacgtagaa 660
tctggggtcc ctgccaggtt tagtggcagt gggtctggga cagactttag cctcaacatc 720
catcctgtgg aggaggatga tattgcaatg tatttctgtc agcaaagtag gaaggttcca 780
tggacgttcg gtggaggcac caagctggaa atcaagtcct cgagcgcctc caccaagggc 840
ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg 900
ggctgcctgg tcaaggacta cttccccgag ccggtgacgg tgtcgtggaa ctcaggcgcc 960
ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc 1020
agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg 1080
aatcacaagc ccagcaacac caaggtggac aagaaagttc gtacggagcc caaatcttct 1140
gacaaaactc acacatgccc accgtgccca tccggagcac ctgaactcct gggtggaccg 1200
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1260
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1320
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 1380
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1440
tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1500
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1560
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatccaag cgacatcgcc 1620
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1680
gactccgacg gctccttcgc actcgccagc aagctcaccg tggacaagag caggtggcag 1740
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1800
aagagcctct ccctgtctcc gggtaaa                                     1827

<210> 30
<211> 609
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0116

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 30
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Ser Val
                 1               5                  10          
Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser
        15                  20                  25              
Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly
    30                  35                  40                  
Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn
45                  50                  55                  60  
Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser
                65                  70                  75      
Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg
            80                  85                  90          
Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met
        95                  100                 105             
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly
    110                 115                 120                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
125                 130                 135                 140 
Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
                145                 150                 155     
Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr
            160                 165                 170         
Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        175                 180                 185             
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro
    190                 195                 200                 
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile
205                 210                 215                 220 
His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser
                225                 230                 235     
Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            240                 245                 250         
Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
        255                 260                 265             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
    270                 275                 280                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
285                 290                 295                 300 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                305                 310                 315     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
            320                 325                 330         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
        335                 340                 345             
Val Asp Lys Lys Val Arg Thr Glu Pro Lys Ser Ser Asp Lys Thr His
    350                 355                 360                 
Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro
365                 370                 375                 380 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                385                 390                 395     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            400                 405                 410         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        415                 420                 425             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    430                 435                 440                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
445                 450                 455                 460 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                465                 470                 475     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            480                 485                 490         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        495                 500                 505             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    510                 515                 520                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
525                 530                 535                 540 
Asp Ser Asp Gly Ser Phe Ala Leu Ala Ser Lys Leu Thr Val Asp Lys
                545                 550                 555     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            560                 565                 570         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        575                 580                 585             
Lys
    


<210> 31
<211> 1083
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0117

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 31
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 120
actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg 180
aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc 240
aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa 300
cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 360
ttcaacaggg gagagcgtac ggagcccaaa tcttctgaca aaactcacac atgcccaccg 420
tgcccatccg gagcacctga actcctgggt ggaccgtcag tcttcctctt ccccccaaaa 480
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 540
agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 600
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 660
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 720
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 780
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 840
tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag 900
ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcgcactc 960
gccagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 1020
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 1080
aaa                                                               1083

<210> 32
<211> 361
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0117

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 32
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
                 1               5                  10          
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
        15                  20                  25              
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
    30                  35                  40                  
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
45                  50                  55                  60  
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
                65                  70                  75      
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
            80                  85                  90          
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu
        95                  100                 105             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly
    110                 115                 120                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
125                 130                 135                 140 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                145                 150                 155     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            160                 165                 170         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        175                 180                 185             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    190                 195                 200                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
205                 210                 215                 220 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                225                 230                 235     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            240                 245                 250         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        255                 260                 265             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    270                 275                 280                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Ala Leu
285                 290                 295                 300 
Ala Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                305                 310                 315     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            320                 325                 330         
Lys Ser Leu Ser Leu Ser Pro Gly Lys
        335                 340     


<210> 33
<211> 1089
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0118

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 33
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
tcctcggagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc atccggagca 120
cctgaactcc tgggtggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc 180
atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct 240
gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg 300
cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag 360
gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc 420
atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg 480
cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc 540
ttctatccaa gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac 600
aagaccacgc ctcccgtgct ggactccgac ggctccttcg cactcgccag caagctcacc 660
gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct 720
ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatc tagaactgtg 780
gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc tggaactgcc 840
tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca gtggaaggtg 900
gataacgccc tccaatcggg taactcccag gagagtgtca cagagcagga cagcaaggac 960
agcacctaca gcctcagcag caccctgacg ctgagcaaag cagactacga gaaacacaaa 1020
gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa gagcttcaac 1080
aggggagag                                                         1089

<210> 34
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0118

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 34
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr
                 1               5                  10          
Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro Ser
        15                  20                  25              
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    30                  35                  40                  
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
45                  50                  55                  60  
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                65                  70                  75      
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
            80                  85                  90          
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        95                  100                 105             
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
    110                 115                 120                 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
125                 130                 135                 140 
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
                145                 150                 155     
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            160                 165                 170         
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        175                 180                 185             
Ser Asp Gly Ser Phe Ala Leu Ala Ser Lys Leu Thr Val Asp Lys Ser
    190                 195                 200                 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
205                 210                 215                 220 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                225                 230                 235     
Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
            240                 245                 250         
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
        255                 260                 265             
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
    270                 275                 280                 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
285                 290                 295                 300 
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
                305                 310                 315     
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
            320                 325                 330         
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
        335                 340             


<210> 35
<211> 1827
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0119

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 35
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
caggtgcagc tgaaggagtc aggacctggc agcgtggcgc cctcacagag cctgtccatc 120
acatgcaccg tctcagggtt ctcattaacc ggctatggtg taaactgggt tcgccagcct 180
ccaggaaagg gtctggagtg gctgggaatg atatggggtg atggaagcac agactataat 240
tcagctctca aatccagact atcgatcacc aaggacaact ccaagagcca agttttctta 300
aaaatgaaca gtctgcaaac tgatgacaca gccagatact actgtgctcg ggatggttat 360
agtaactttc attactatgt tatggactac tggggtcaag gaacctcagt caccgtctcc 420
tctgggggtg gaggctctgg tggcggtgga tccggcggag gtgggtcggg tggcggcgga 480
tctgacattg tgctcaccca atctccagct tctttggctg tgtctctagg tcagagagcc 540
accatctcct gcagagccag tgaaagtgtt gaatattatg tcacaagttt aatgcagtgg 600
taccaacaga aaccaggaca gccacccaaa ctcctcatct ctgctgctag caacgtagaa 660
tctggggtcc ctgccaggtt tagtggcagt gggtctggga cagactttag cctcaacatc 720
catcctgtgg aggaggatga tattgcaatg tatttctgtc agcaaagtag gaaggttcca 780
tggacgttcg gtggaggcac caagctggaa atcaagtcct cgagcgagcc caaatcttct 840
gacaaaactc acacatgccc accgtgccca tccggagcac ctgaactcct gggtggaccg 900
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 960
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1020
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 1080
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1140
tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1200
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1260
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatccaag cgacatcgcc 1320
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1380
gactccgacg gctccttcgc actcgccagc aagctcaccg tggacaagag caggtggcag 1440
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1500
aagagcctct ccctgtctcc gggtaaatct agagcctcca ccaagggccc atcggtcttc 1560
cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc 1620
aaggactact tccccgagcc ggtgacggtg tcgtggaact caggcgccct gaccagcggc 1680
gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg 1740
accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc 1800
agcaacacca aggtggacaa gaaagtt                                     1827

<210> 36
<211> 609
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0119

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 36
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Ser Val
                 1               5                  10          
Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser
        15                  20                  25              
Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly
    30                  35                  40                  
Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn
45                  50                  55                  60  
Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser
                65                  70                  75      
Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg
            80                  85                  90          
Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met
        95                  100                 105             
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly
    110                 115                 120                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
125                 130                 135                 140 
Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
                145                 150                 155     
Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr
            160                 165                 170         
Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        175                 180                 185             
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro
    190                 195                 200                 
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile
205                 210                 215                 220 
His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser
                225                 230                 235     
Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            240                 245                 250         
Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro
        255                 260                 265             
Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
    270                 275                 280                 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
285                 290                 295                 300 
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                305                 310                 315     
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
            320                 325                 330         
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
        335                 340                 345             
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
    350                 355                 360                 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
365                 370                 375                 380 
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
                385                 390                 395     
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
            400                 405                 410         
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
        415                 420                 425             
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
    430                 435                 440                 
Ser Phe Ala Leu Ala Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
445                 450                 455                 460 
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
                465                 470                 475     
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Ala
            480                 485                 490         
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser
        495                 500                 505             
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
    510                 515                 520                 
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
525                 530                 535                 540 
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
                545                 550                 555     
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
            560                 565                 570         
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys
        575                 580                 585             
Val
    


<210> 37
<211> 2127
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0120

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 37
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
caggtgcagc tgaaggagtc aggacctggc agcgtggcgc cctcacagag cctgtccatc 120
acatgcaccg tctcagggtt ctcattaacc ggctatggtg taaactgggt tcgccagcct 180
ccaggaaagg gtctggagtg gctgggaatg atatggggtg atggaagcac agactataat 240
tcagctctca aatccagact atcgatcacc aaggacaact ccaagagcca agttttctta 300
aaaatgaaca gtctgcaaac tgatgacaca gccagatact actgtgctcg ggatggttat 360
agtaactttc attactatgt tatggactac tggggtcaag gaacctcagt caccgtctcc 420
tctgggggtg gaggctctgg tggcggtgga tccggcggag gtgggtcggg tggcggcgga 480
tctgacattg tgctcaccca atctccagct tctttggctg tgtctctagg tcagagagcc 540
accatctcct gcagagccag tgaaagtgtt gaatattatg tcacaagttt aatgcagtgg 600
taccaacaga aaccaggaca gccacccaaa ctcctcatct ctgctgctag caacgtagaa 660
tctggggtcc ctgccaggtt tagtggcagt gggtctggga cagactttag cctcaacatc 720
catcctgtgg aggaggatga tattgcaatg tatttctgtc agcaaagtag gaaggttcca 780
tggacgttcg gtggaggcac caagctggaa atcaagtcct cgagcgcctc caccaagggc 840
ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg 900
ggctgcctgg tcaaggacta cttccccgag ccggtgacgg tgtcgtggaa ctcaggcgcc 960
ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc 1020
agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg 1080
aatcacaagc ccagcaacac caaggtggac aagaaagttc gtacggagcc caaatcttct 1140
gacaaaactc acacatgccc accgtgccca tccggagcac ctgaactcct gggtggaccg 1200
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1260
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1320
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 1380
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1440
tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1500
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1560
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatccaag cgacatcgcc 1620
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1680
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1740
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1800
aagagcctct ccctgtctcc gggtaaatct agagcctcca ccaagggccc atcggtcttc 1860
cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc 1920
aaggactact tccccgagcc ggtgacggtg tcgtggaact caggcgccct gaccagcggc 1980
gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg 2040
accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc 2100
agcaacacca aggtggacaa gaaagtt                                     2127

<210> 38
<211> 709
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0120

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 38
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Ser Val
                 1               5                  10          
Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser
        15                  20                  25              
Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly
    30                  35                  40                  
Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn
45                  50                  55                  60  
Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser
                65                  70                  75      
Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg
            80                  85                  90          
Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met
        95                  100                 105             
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly
    110                 115                 120                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
125                 130                 135                 140 
Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
                145                 150                 155     
Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr
            160                 165                 170         
Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        175                 180                 185             
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro
    190                 195                 200                 
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile
205                 210                 215                 220 
His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser
                225                 230                 235     
Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            240                 245                 250         
Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
        255                 260                 265             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
    270                 275                 280                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
285                 290                 295                 300 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                305                 310                 315     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
            320                 325                 330         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
        335                 340                 345             
Val Asp Lys Lys Val Arg Thr Glu Pro Lys Ser Ser Asp Lys Thr His
    350                 355                 360                 
Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro
365                 370                 375                 380 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                385                 390                 395     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            400                 405                 410         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        415                 420                 425             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    430                 435                 440                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
445                 450                 455                 460 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                465                 470                 475     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            480                 485                 490         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        495                 500                 505             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    510                 515                 520                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
525                 530                 535                 540 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                545                 550                 555     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            560                 565                 570         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        575                 580                 585             
Lys Ser Arg Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
    590                 595                 600                 
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
605                 610                 615                 620 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                625                 630                 635     
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
            640                 645                 650         
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
        655                 660                 665             
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
    670                 675                 680                 
Val Asp Lys Lys Val
685                 


<210> 39
<211> 1404
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0121

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 39
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 120
actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg 180
aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc 240
aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa 300
cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 360
ttcaacaggg gagagcgtac ggagcccaaa tcttctgaca aaactcacac atgcccaccg 420
tgcccatccg gagcacctga actcctgggt ggaccgtcag tcttcctctt ccccccaaaa 480
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 540
agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 600
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 660
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 720
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 780
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 840
tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag 900
ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 960
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 1020
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 1080
aaatctagaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg 1140
aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa 1200
gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag 1260
caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac 1320
tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc 1380
acaaagagct tcaacagggg agag                                        1404

<210> 40
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0121

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 40
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
                 1               5                  10          
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
        15                  20                  25              
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
    30                  35                  40                  
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
45                  50                  55                  60  
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
                65                  70                  75      
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
            80                  85                  90          
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu
        95                  100                 105             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly
    110                 115                 120                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
125                 130                 135                 140 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                145                 150                 155     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            160                 165                 170         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        175                 180                 185             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    190                 195                 200                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
205                 210                 215                 220 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                225                 230                 235     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            240                 245                 250         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        255                 260                 265             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    270                 275                 280                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
285                 290                 295                 300 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                305                 310                 315     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            320                 325                 330         
Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Thr Val Ala Ala Pro
        335                 340                 345             
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
    350                 355                 360                 
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
365                 370                 375                 380 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                385                 390                 395     
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
            400                 405                 410         
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
        415                 420                 425             
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
    430                 435                 440                 
Asn Arg Gly Glu
445             


<210> 41
<211> 1404
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0122

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 41
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 120
actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg 180
aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc 240
aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa 300
cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 360
ttcaacaggg gagagcgtac ggagcccaaa tcttctgaca aaactcacac atgcccaccg 420
tgcccatccg gagcacctga actcctgggt ggaccgtcag tcttcctctt ccccccaaaa 480
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 540
agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 600
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 660
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 720
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 780
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 840
tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag 900
ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 960
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 1020
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 1080
aaatctagaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg 1140
aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa 1200
gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag 1260
caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac 1320
tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc 1380
acaaagagct tcaacagggg agag                                        1404

<210> 42
<211> 709
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0122

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 42
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Ser Val
                 1               5                  10          
Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser
        15                  20                  25              
Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly
    30                  35                  40                  
Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn
45                  50                  55                  60  
Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser
                65                  70                  75      
Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg
            80                  85                  90          
Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met
        95                  100                 105             
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly
    110                 115                 120                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
125                 130                 135                 140 
Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
                145                 150                 155     
Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr
            160                 165                 170         
Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        175                 180                 185             
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro
    190                 195                 200                 
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile
205                 210                 215                 220 
His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser
                225                 230                 235     
Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            240                 245                 250         
Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
        255                 260                 265             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
    270                 275                 280                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
285                 290                 295                 300 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                305                 310                 315     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
            320                 325                 330         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
        335                 340                 345             
Val Asp Lys Lys Val Arg Thr Glu Pro Lys Ser Ser Asp Lys Thr His
    350                 355                 360                 
Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro
365                 370                 375                 380 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                385                 390                 395     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            400                 405                 410         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        415                 420                 425             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    430                 435                 440                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
445                 450                 455                 460 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                465                 470                 475     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            480                 485                 490         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        495                 500                 505             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    510                 515                 520                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
525                 530                 535                 540 
Asp Ser Asp Gly Ser Phe Ala Leu Ala Ser Lys Leu Thr Val Asp Lys
                545                 550                 555     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            560                 565                 570         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        575                 580                 585             
Lys Ser Arg Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
    590                 595                 600                 
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
605                 610                 615                 620 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                625                 630                 635     
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
            640                 645                 650         
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
        655                 660                 665             
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
    670                 675                 680                 
Val Asp Lys Lys Val
685                 


<210> 43
<211> 1404
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0123

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 43
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 120
actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg 180
aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc 240
aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa 300
cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 360
ttcaacaggg gagagcgtac ggagcccaaa tcttctgaca aaactcacac atgcccaccg 420
tgcccatccg gagcacctga actcctgggt ggaccgtcag tcttcctctt ccccccaaaa 480
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 540
agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 600
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 660
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 720
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 780
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 840
tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag 900
ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcgcactc 960
gccagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 1020
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 1080
aaatctagaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg 1140
aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa 1200
gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag 1260
caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac 1320
tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc 1380
acaaagagct tcaacagggg agag                                        1404

<210> 44
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0123

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 44
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
                 1               5                  10          
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
        15                  20                  25              
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
    30                  35                  40                  
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
45                  50                  55                  60  
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
                65                  70                  75      
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
            80                  85                  90          
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu
        95                  100                 105             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly
    110                 115                 120                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
125                 130                 135                 140 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                145                 150                 155     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            160                 165                 170         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        175                 180                 185             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    190                 195                 200                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
205                 210                 215                 220 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                225                 230                 235     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            240                 245                 250         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        255                 260                 265             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    270                 275                 280                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Ala Leu
285                 290                 295                 300 
Ala Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                305                 310                 315     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            320                 325                 330         
Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Thr Val Ala Ala Pro
        335                 340                 345             
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
    350                 355                 360                 
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
365                 370                 375                 380 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                385                 390                 395     
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
            400                 405                 410         
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
        415                 420                 425             
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
    430                 435                 440                 
Asn Arg Gly Glu
445             


<210> 45
<211> 2148
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0130

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 45
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
caggtgcagc tgaaggagtc aggacctggc agcgtggcgc cctcacagag cctgtccatc 120
acatgcaccg tctcagggtt ctcattaacc ggctatggtg taaactgggt tcgccagcct 180
ccaggaaagg gtctggagtg gctgggaatg atatggggtg atggaagcac agactataat 240
tcagctctca aatccagact atcgatcacc aaggacaact ccaagagcca agttttctta 300
aaaatgaaca gtctgcaaac tgatgacaca gccagatact actgtgctcg ggatggttat 360
agtaactttc attactatgt tatggactac tggggtcaag gaacctcagt caccgtctcc 420
tctgggggtg gaggctctgg tggcggtgga tccggcggag gtgggtcggg tggcggcgga 480
tctgacattg tgctcaccca atctccagct tctttggctg tgtctctagg tcagagagcc 540
accatctcct gcagagccag tgaaagtgtt gaatattatg tcacaagttt aatgcagtgg 600
taccaacaga aaccaggaca gccacccaaa ctcctcatct ctgctgctag caacgtagaa 660
tctggggtcc ctgccaggtt tagtggcagt gggtctggga cagactttag cctcaacatc 720
catcctgtgg aggaggatga tattgcaatg tatttctgtc agcaaagtag gaaggttcca 780
tggacgttcg gtggaggcac caagctggaa atcaagtcct cgagcgcctc caccaagggc 840
ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg 900
ggctgcctgg tcaaggacta cttccccgag ccggtgacgg tgtcgtggaa ctcaggcgcc 960
ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc 1020
agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg 1080
aatcacaagc ccagcaacac caaggtggac aagaaagttc gtacggagcc caaatcttct 1140
gacaaaactc acacatgccc accgtgccca tccggagcac ctgaactcct gggtggaccg 1200
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1260
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1320
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 1380
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1440
tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1500
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1560
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatccaag cgacatcgcc 1620
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1680
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1740
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1800
aagagcctct ccctgtctcc gggtaaatct agaactgtgg ctgcaccatc tgtcttcatc 1860
ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat 1920
aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt 1980
aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc 2040
accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc 2100
catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagag              2148

<210> 46
<211> 716
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0130

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 46
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Ser Val
                 1               5                  10          
Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser
        15                  20                  25              
Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly
    30                  35                  40                  
Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn
45                  50                  55                  60  
Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser
                65                  70                  75      
Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg
            80                  85                  90          
Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met
        95                  100                 105             
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly
    110                 115                 120                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
125                 130                 135                 140 
Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
                145                 150                 155     
Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr
            160                 165                 170         
Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        175                 180                 185             
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro
    190                 195                 200                 
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile
205                 210                 215                 220 
His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser
                225                 230                 235     
Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            240                 245                 250         
Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
        255                 260                 265             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
    270                 275                 280                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
285                 290                 295                 300 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                305                 310                 315     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
            320                 325                 330         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
        335                 340                 345             
Val Asp Lys Lys Val Arg Thr Glu Pro Lys Ser Ser Asp Lys Thr His
    350                 355                 360                 
Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro
365                 370                 375                 380 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                385                 390                 395     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            400                 405                 410         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        415                 420                 425             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    430                 435                 440                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
445                 450                 455                 460 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                465                 470                 475     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            480                 485                 490         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        495                 500                 505             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    510                 515                 520                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
525                 530                 535                 540 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                545                 550                 555     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            560                 565                 570         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        575                 580                 585             
Lys Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
    590                 595                 600                 
Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn
605                 610                 615                 620 
Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
                625                 630                 635     
Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys
            640                 645                 650         
Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp
        655                 660                 665             
Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu
    670                 675                 680                 
Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
685                 690                 695     


<210> 47
<211> 1383
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0131

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 47
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 120
actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg 180
aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc 240
aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa 300
cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 360
ttcaacaggg gagagcgtac ggagcccaaa tcttctgaca aaactcacac atgcccaccg 420
tgcccatccg gagcacctga actcctgggt ggaccgtcag tcttcctctt ccccccaaaa 480
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 540
agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 600
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 660
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 720
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 780
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 840
tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag 900
ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 960
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 1020
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 1080
aaatctagag cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc 1140
acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgagccggtg 1200
acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta 1260
cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc 1320
acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa 1380
gtt                                                               1383

<210> 48
<211> 461
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0131

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 48
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
                 1               5                  10          
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
        15                  20                  25              
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
    30                  35                  40                  
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
45                  50                  55                  60  
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
                65                  70                  75      
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
            80                  85                  90          
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu
        95                  100                 105             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly
    110                 115                 120                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
125                 130                 135                 140 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                145                 150                 155     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            160                 165                 170         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        175                 180                 185             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    190                 195                 200                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
205                 210                 215                 220 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                225                 230                 235     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            240                 245                 250         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        255                 260                 265             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    270                 275                 280                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
285                 290                 295                 300 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                305                 310                 315     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            320                 325                 330         
Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Ala Ser Thr Lys Gly
        335                 340                 345             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    350                 355                 360                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
365                 370                 375                 380 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                385                 390                 395     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            400                 405                 410         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        415                 420                 425             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
    430                 435                 440     


<210> 49
<211> 1083
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0133

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 49
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
cagcccaagg ccaaccccac tgtcactctg ttcccgccct cctctgagga gctccaagcc 120
aacaaggcca cactagtgtg tctgatcagt gacttctacc cgggagctgt gacagtggcc 180
tggaaggcag atggcagccc cgtcaaggcg ggagtggaga ccaccaaacc ctccaaacag 240
agcaataaca agtacgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc 300
cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc 360
cctacagaat cctcacgtac ggagcccaaa tcttctgaca aaactcacac atgcccaccg 420
tgcccatccg gagcacctga actcctgggt ggaccgtcag tcttcctctt ccccccaaaa 480
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 540
agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 600
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 660
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 720
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 780
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 840
tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag 900
ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 960
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 1020
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 1080
aaa                                                               1083

<210> 50
<211> 361
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0133

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 50
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro
                 1               5                  10          
Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu
        15                  20                  25              
Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp
    30                  35                  40                  
Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln
45                  50                  55                  60  
Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu
                65                  70                  75      
Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly
            80                  85                  90          
Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Ser Ser Arg Thr Glu
        95                  100                 105             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly
    110                 115                 120                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
125                 130                 135                 140 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                145                 150                 155     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            160                 165                 170         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        175                 180                 185             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    190                 195                 200                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
205                 210                 215                 220 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                225                 230                 235     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            240                 245                 250         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        255                 260                 265             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    270                 275                 280                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
285                 290                 295                 300 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                305                 310                 315     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            320                 325                 330         
Lys Ser Leu Ser Leu Ser Pro Gly Lys
        335                 340     


<210> 51
<211> 1089
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0134

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 51
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
tcctcggagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc atccggagca 120
cctgaactcc tgggtggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc 180
atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct 240
gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg 300
cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag 360
gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc 420
atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg 480
cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc 540
ttctatccaa gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac 600
aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc 660
gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct 720
ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatc tagacagccc 780
aaggccaacc ccactgtcac tctgttcccg ccctcctctg aggagctcca agccaacaag 840
gccacactag tgtgtctgat cagtgacttc tacccgggag ctgtgacagt ggcctggaag 900
gcagatggca gccccgtcaa ggcgggagtg gagaccacca aaccctccaa acagagcaac 960
aacaagtacg cggccagcag ctacctgagc ctgacgcccg agcagtggaa gtcccacaga 1020
agctacagct gccaggtcac gcatgaaggg agcaccgtgg agaagacagt ggcccctaca 1080
gaatcctca                                                         1089

<210> 52
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0134

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 52
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr
                 1               5                  10          
Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro Ser
        15                  20                  25              
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    30                  35                  40                  
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
45                  50                  55                  60  
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                65                  70                  75      
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
            80                  85                  90          
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        95                  100                 105             
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
    110                 115                 120                 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
125                 130                 135                 140 
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
                145                 150                 155     
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            160                 165                 170         
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        175                 180                 185             
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
    190                 195                 200                 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
205                 210                 215                 220 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                225                 230                 235     
Ser Arg Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser
            240                 245                 250         
Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser
        255                 260                 265             
Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser
    270                 275                 280                 
Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn
285                 290                 295                 300 
Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp
                305                 310                 315     
Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr
            320                 325                 330         
Val Glu Lys Thr Val Ala Pro Thr Glu Ser Ser
        335                 340             


<210> 53
<211> 1089
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0136

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 53
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
tcctcggagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc atccggagca 120
cctgaactcc tgggtggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc 180
atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct 240
gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg 300
cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag 360
gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc 420
atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg 480
cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc 540
ttctatccaa gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac 600
aagaccacgc ctcccgtgct ggactccgac ggctccttcg cactctacag caagctcacc 660
gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct 720
ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatc tagaactgtg 780
gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc tggaactgcc 840
tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca gtggaaggtg 900
gataacgccc tccaatcggg taactcccag gagagtgtca cagagcagga cagcaaggac 960
agcacctaca gcctcagcag caccctgacg ctgagcaaag cagactacga gaaacacaaa 1020
gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa gagcttcaac 1080
aggggagag                                                         1089

<210> 54
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0136

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 54
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr
                 1               5                  10          
Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro Ser
        15                  20                  25              
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    30                  35                  40                  
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
45                  50                  55                  60  
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                65                  70                  75      
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
            80                  85                  90          
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        95                  100                 105             
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
    110                 115                 120                 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
125                 130                 135                 140 
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
                145                 150                 155     
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            160                 165                 170         
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        175                 180                 185             
Ser Asp Gly Ser Phe Ala Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
    190                 195                 200                 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
205                 210                 215                 220 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                225                 230                 235     
Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
            240                 245                 250         
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
        255                 260                 265             
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
    270                 275                 280                 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
285                 290                 295                 300 
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
                305                 310                 315     
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
            320                 325                 330         
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
        335                 340             


<210> 55
<211> 1827
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0137

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 55
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
caggtgcagc tgaaggagtc aggacctggc agcgtggcgc cctcacagag cctgtccatc 120
acatgcaccg tctcagggtt ctcattaacc ggctatggtg taaactgggt tcgccagcct 180
ccaggaaagg gtctggagtg gctgggaatg atatggggtg atggaagcac agactataat 240
tcagctctca aatccagact atcgatcacc aaggacaact ccaagagcca agttttctta 300
aaaatgaaca gtctgcaaac tgatgacaca gccagatact actgtgctcg ggatggttat 360
agtaactttc attactatgt tatggactac tggggtcaag gaacctcagt caccgtctcc 420
tctgggggtg gaggctctgg tggcggtgga tccggcggag gtgggtcggg tggcggcgga 480
tctgacattg tgctcaccca atctccagct tctttggctg tgtctctagg tcagagagcc 540
accatctcct gcagagccag tgaaagtgtt gaatattatg tcacaagttt aatgcagtgg 600
taccaacaga aaccaggaca gccacccaaa ctcctcatct ctgctgctag caacgtagaa 660
tctggggtcc ctgccaggtt tagtggcagt gggtctggga cagactttag cctcaacatc 720
catcctgtgg aggaggatga tattgcaatg tatttctgtc agcaaagtag gaaggttcca 780
tggacgttcg gtggaggcac caagctggaa atcaagtcct cgagcgagcc caaatcttct 840
gacaaaactc acacatgccc accgtgccca tccggagcac ctgaactcct gggtggaccg 900
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 960
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1020
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 1080
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1140
tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1200
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1260
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatccaag cgacatcgcc 1320
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1380
gactccgacg gctccttcgc actctacagc aagctcaccg tggacaagag caggtggcag 1440
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1500
aagagcctct ccctgtctcc gggtaaatct agagcctcca ccaagggccc atcggtcttc 1560
cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc 1620
aaggactact tccccgagcc ggtgacggtg tcgtggaact caggcgccct gaccagcggc 1680
gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg 1740
accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc 1800
agcaacacca aggtggacaa gaaagtt                                     1827

<210> 56
<211> 609
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0137

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 56
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Ser Val
                 1               5                  10          
Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser
        15                  20                  25              
Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly
    30                  35                  40                  
Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn
45                  50                  55                  60  
Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser
                65                  70                  75      
Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg
            80                  85                  90          
Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met
        95                  100                 105             
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly
    110                 115                 120                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
125                 130                 135                 140 
Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
                145                 150                 155     
Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr
            160                 165                 170         
Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        175                 180                 185             
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro
    190                 195                 200                 
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile
205                 210                 215                 220 
His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser
                225                 230                 235     
Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            240                 245                 250         
Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro
        255                 260                 265             
Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
    270                 275                 280                 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
285                 290                 295                 300 
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                305                 310                 315     
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
            320                 325                 330         
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
        335                 340                 345             
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
    350                 355                 360                 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
365                 370                 375                 380 
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
                385                 390                 395     
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
            400                 405                 410         
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
        415                 420                 425             
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
    430                 435                 440                 
Ser Phe Ala Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
445                 450                 455                 460 
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
                465                 470                 475     
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Ala
            480                 485                 490         
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser
        495                 500                 505             
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
    510                 515                 520                 
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
525                 530                 535                 540 
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
                545                 550                 555     
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
            560                 565                 570         
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys
        575                 580                 585             
Val
    


<210> 57
<211> 1089
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0139

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 57
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
tcctcggagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc atccggagca 120
cctgaactcc tgggtggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc 180
atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct 240
gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg 300
cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag 360
gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc 420
atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg 480
cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc 540
ttctatccaa gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac 600
aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctcgccag caagctcacc 660
gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct 720
ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatc tagaactgtg 780
gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc tggaactgcc 840
tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca gtggaaggtg 900
gataacgccc tccaatcggg taactcccag gagagtgtca cagagcagga cagcaaggac 960
agcacctaca gcctcagcag caccctgacg ctgagcaaag cagactacga gaaacacaaa 1020
gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa gagcttcaac 1080
aggggagag                                                         1089

<210> 58
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0139

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 58
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr
                 1               5                  10          
Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro Ser
        15                  20                  25              
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    30                  35                  40                  
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
45                  50                  55                  60  
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                65                  70                  75      
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
            80                  85                  90          
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        95                  100                 105             
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
    110                 115                 120                 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
125                 130                 135                 140 
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
                145                 150                 155     
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            160                 165                 170         
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        175                 180                 185             
Ser Asp Gly Ser Phe Phe Leu Ala Ser Lys Leu Thr Val Asp Lys Ser
    190                 195                 200                 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
205                 210                 215                 220 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                225                 230                 235     
Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
            240                 245                 250         
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
        255                 260                 265             
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
    270                 275                 280                 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
285                 290                 295                 300 
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
                305                 310                 315     
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
            320                 325                 330         
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
        335                 340             


<210> 59
<211> 1827
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0140

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 59
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
caggtgcagc tgaaggagtc aggacctggc agcgtggcgc cctcacagag cctgtccatc 120
acatgcaccg tctcagggtt ctcattaacc ggctatggtg taaactgggt tcgccagcct 180
ccaggaaagg gtctggagtg gctgggaatg atatggggtg atggaagcac agactataat 240
tcagctctca aatccagact atcgatcacc aaggacaact ccaagagcca agttttctta 300
aaaatgaaca gtctgcaaac tgatgacaca gccagatact actgtgctcg ggatggttat 360
agtaactttc attactatgt tatggactac tggggtcaag gaacctcagt caccgtctcc 420
tctgggggtg gaggctctgg tggcggtgga tccggcggag gtgggtcggg tggcggcgga 480
tctgacattg tgctcaccca atctccagct tctttggctg tgtctctagg tcagagagcc 540
accatctcct gcagagccag tgaaagtgtt gaatattatg tcacaagttt aatgcagtgg 600
taccaacaga aaccaggaca gccacccaaa ctcctcatct ctgctgctag caacgtagaa 660
tctggggtcc ctgccaggtt tagtggcagt gggtctggga cagactttag cctcaacatc 720
catcctgtgg aggaggatga tattgcaatg tatttctgtc agcaaagtag gaaggttcca 780
tggacgttcg gtggaggcac caagctggaa atcaagtcct cgagcgagcc caaatcttct 840
gacaaaactc acacatgccc accgtgccca tccggagcac ctgaactcct gggtggaccg 900
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 960
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1020
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 1080
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1140
tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1200
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1260
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatccaag cgacatcgcc 1320
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1380
gactccgacg gctccttctt cctcgccagc aagctcaccg tggacaagag caggtggcag 1440
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1500
aagagcctct ccctgtctcc gggtaaatct agagcctcca ccaagggccc atcggtcttc 1560
cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc 1620
aaggactact tccccgagcc ggtgacggtg tcgtggaact caggcgccct gaccagcggc 1680
gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg 1740
accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc 1800
agcaacacca aggtggacaa gaaagtt                                     1827

<210> 60
<211> 609
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0140

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 60
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Ser Val
                 1               5                  10          
Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser
        15                  20                  25              
Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly
    30                  35                  40                  
Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn
45                  50                  55                  60  
Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser
                65                  70                  75      
Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg
            80                  85                  90          
Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met
        95                  100                 105             
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly
    110                 115                 120                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
125                 130                 135                 140 
Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
                145                 150                 155     
Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr
            160                 165                 170         
Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        175                 180                 185             
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro
    190                 195                 200                 
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile
205                 210                 215                 220 
His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser
                225                 230                 235     
Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            240                 245                 250         
Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro
        255                 260                 265             
Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
    270                 275                 280                 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
285                 290                 295                 300 
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                305                 310                 315     
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
            320                 325                 330         
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
        335                 340                 345             
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
    350                 355                 360                 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
365                 370                 375                 380 
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
                385                 390                 395     
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
            400                 405                 410         
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
        415                 420                 425             
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
    430                 435                 440                 
Ser Phe Phe Leu Ala Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
445                 450                 455                 460 
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
                465                 470                 475     
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Ala
            480                 485                 490         
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser
        495                 500                 505             
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
    510                 515                 520                 
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
525                 530                 535                 540 
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
                545                 550                 555     
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
            560                 565                 570         
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys
        575                 580                 585             
Val
    


<210> 61
<211> 2148
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0146

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 61
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
caggtgcagc tgaaggagtc aggacctggc agcgtggcgc cctcacagag cctgtccatc 120
acatgcaccg tctcagggtt ctcattaacc ggctatggtg taaactgggt tcgccagcct 180
ccaggaaagg gtctggagtg gctgggaatg atatggggtg atggaagcac agactataat 240
tcagctctca aatccagact atcgatcacc aaggacaact ccaagagcca agttttctta 300
aaaatgaaca gtctgcaaac tgatgacaca gccagatact actgtgctcg ggatggttat 360
agtaactttc attactatgt tatggactac tggggtcaag gaacctcagt caccgtctcc 420
tctgggggtg gaggctctgg tggcggtgga tccggcggag gtgggtcggg tggcggcgga 480
tctgacattg tgctcaccca atctccagct tctttggctg tgtctctagg tcagagagcc 540
accatctcct gcagagccag tgaaagtgtt gaatattatg tcacaagttt aatgcagtgg 600
taccaacaga aaccaggaca gccacccaaa ctcctcatct ctgctgctag caacgtagaa 660
tctggggtcc ctgccaggtt tagtggcagt gggtctggga cagactttag cctcaacatc 720
catcctgtgg aggaggatga tattgcaatg tatttctgtc agcaaagtag gaaggttcca 780
tggacgttcg gtggaggcac caagctggaa atcaagtcct cgagcgcctc caccaagggc 840
ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg 900
ggctgcctgg tcaaggacta cttccccgag ccggtgacgg tgtcgtggaa ctcaggcgcc 960
ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc 1020
agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg 1080
aatcacaagc ccagcaacac caaggtggac aagaaagttc gtacggagcc caaatcttct 1140
gacaaaactc acacatgccc accgtgccca tccggagcac ctgaactcct gggtggaccg 1200
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1260
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1320
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 1380
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1440
tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1500
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1560
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatccaag cgacatcgcc 1620
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1680
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1740
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1800
aagagcctct ccctgtctcc gggtaaatct agacagccca aggccaaccc cactgtcact 1860
ctgttcccgc cctcctctga ggagctccaa gccaacaagg ccacactagt gtgtctgatc 1920
agtgacttct acccgggagc tgtgacagtg gcctggaagg cagatggcag ccccgtcaag 1980
gcgggagtgg agaccaccaa accctccaaa cagagcaaca acaagtacgc ggccagcagc 2040
tacctgagcc tgacgcccga gcagtggaag tcccacagaa gctacagctg ccaggtcacg 2100
catgaaggga gcaccgtgga gaagacagtg gcccctacag aatcctca              2148

<210> 62
<211> 716
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0146

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 62
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Ser Val
                 1               5                  10          
Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser
        15                  20                  25              
Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly
    30                  35                  40                  
Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn
45                  50                  55                  60  
Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser
                65                  70                  75      
Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg
            80                  85                  90          
Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met
        95                  100                 105             
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly
    110                 115                 120                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
125                 130                 135                 140 
Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
                145                 150                 155     
Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr
            160                 165                 170         
Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        175                 180                 185             
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro
    190                 195                 200                 
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile
205                 210                 215                 220 
His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser
                225                 230                 235     
Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            240                 245                 250         
Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
        255                 260                 265             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
    270                 275                 280                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
285                 290                 295                 300 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
                305                 310                 315     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
            320                 325                 330         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
        335                 340                 345             
Val Asp Lys Lys Val Arg Thr Glu Pro Lys Ser Ser Asp Lys Thr His
    350                 355                 360                 
Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro
365                 370                 375                 380 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                385                 390                 395     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            400                 405                 410         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        415                 420                 425             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    430                 435                 440                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
445                 450                 455                 460 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                465                 470                 475     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            480                 485                 490         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        495                 500                 505             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    510                 515                 520                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
525                 530                 535                 540 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                545                 550                 555     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            560                 565                 570         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        575                 580                 585             
Lys Ser Arg Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro
    590                 595                 600                 
Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile
605                 610                 615                 620 
Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly
                625                 630                 635     
Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser
            640                 645                 650         
Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln
        655                 660                 665             
Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser
    670                 675                 680                 
Thr Val Glu Lys Thr Val Ala Pro Thr Glu Ser Ser
685                 690                 695     


<210> 63
<211> 1383
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0147

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 63
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
cagcccaagg ccaaccccac tgtcactctg ttcccgccct cctctgagga gctccaagcc 120
aacaaggcca cactagtgtg tctgatcagt gacttctacc cgggagctgt gacagtggcc 180
tggaaggcag atggcagccc cgtcaaggcg ggagtggaga ccaccaaacc ctccaaacag 240
agcaacaaca agtacgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc 300
cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc 360
cctacagaat cctcacgtac ggagcccaaa tcttctgaca aaactcacac atgcccaccg 420
tgcccatccg gagcacctga actcctgggt ggaccgtcag tcttcctctt ccccccaaaa 480
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 540
agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 600
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 660
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 720
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 780
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 840
tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag 900
ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 960
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 1020
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 1080
aaatctagag cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc 1140
acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgagccggtg 1200
acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta 1260
cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc 1320
acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa 1380
gtt                                                               1383

<210> 64
<211> 461
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0147

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 64
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro
                 1               5                  10          
Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu
        15                  20                  25              
Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp
    30                  35                  40                  
Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln
45                  50                  55                  60  
Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu
                65                  70                  75      
Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly
            80                  85                  90          
Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Ser Ser Arg Thr Glu
        95                  100                 105             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly
    110                 115                 120                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
125                 130                 135                 140 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                145                 150                 155     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            160                 165                 170         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        175                 180                 185             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    190                 195                 200                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
205                 210                 215                 220 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                225                 230                 235     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            240                 245                 250         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        255                 260                 265             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    270                 275                 280                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
285                 290                 295                 300 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                305                 310                 315     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            320                 325                 330         
Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Ala Ser Thr Lys Gly
        335                 340                 345             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    350                 355                 360                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
365                 370                 375                 380 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                385                 390                 395     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            400                 405                 410         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        415                 420                 425             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
    430                 435                 440     


<210> 65
<211> 1404
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0148

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 65
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
cagcccaagg ccaaccccac tgtcactctg ttcccgccct cctctgagga gctccaagcc 120
aacaaggcca cactagtgtg tctgatcagt gacttctacc cgggagctgt gacagtggcc 180
tggaaggcag atggcagccc cgtcaaggcg ggagtggaga ccaccaaacc ctccaaacag 240
agcaacaaca agtacgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc 300
cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc 360
cctacagaat cctcacgtac ggagcccaaa tcttctgaca aaactcacac atgcccaccg 420
tgcccatccg gagcacctga actcctgggt ggaccgtcag tcttcctctt ccccccaaaa 480
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 540
agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 600
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 660
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 720
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 780
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 840
tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag 900
ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 960
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 1020
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 1080
aaatctagac agcccaaggc caaccccact gtcactctgt tcccgccctc ctctgaggag 1140
ctccaagcca acaaggccac actagtgtgt ctgatcagtg acttctaccc gggagctgtg 1200
acagtggcct ggaaggcaga tggcagcccc gtcaaggcgg gagtggagac caccaaaccc 1260
tccaaacaga gcaacaacaa gtacgcggcc agcagctacc tgagcctgac gcccgagcag 1320
tggaagtccc acagaagcta cagctgccag gtcacgcatg aagggagcac cgtggagaag 1380
acagtggccc ctacagaatc ctca                                        1404

<210> 66
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0148

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 66
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro
                 1               5                  10          
Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu
        15                  20                  25              
Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp
    30                  35                  40                  
Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln
45                  50                  55                  60  
Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu
                65                  70                  75      
Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly
            80                  85                  90          
Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Ser Ser Arg Thr Glu
        95                  100                 105             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly
    110                 115                 120                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
125                 130                 135                 140 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                145                 150                 155     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            160                 165                 170         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        175                 180                 185             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    190                 195                 200                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
205                 210                 215                 220 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                225                 230                 235     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            240                 245                 250         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        255                 260                 265             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    270                 275                 280                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
285                 290                 295                 300 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                305                 310                 315     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            320                 325                 330         
Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Gln Pro Lys Ala Asn
        335                 340                 345             
Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn
    350                 355                 360                 
Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val
365                 370                 375                 380 
Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala Gly Val Glu
                385                 390                 395     
Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser
            400                 405                 410         
Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser
        415                 420                 425             
Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro
    430                 435                 440                 
Thr Glu Ser Ser
445             


<210> 67
<211> 1389
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0167

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 67
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
tcgagcgcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc 120
tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga gccggtgacg 180
gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag 240
tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc 300
cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt 360
cgtacggagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc atccggagca 420
cctgaactcc tgggtggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc 480
atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct 540
gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg 600
cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag 660
gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc 720
atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg 780
cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc 840
ttctatccaa gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac 900
aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc 960
gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct 1020
ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatc tagaactgtg 1080
gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc tggaactgcc 1140
tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca gtggaaggtg 1200
gataacgccc tccaatcggg taactcccag gagagtgtca cagagcagga cagcaaggac 1260
agcacctaca gcctcagcag caccctgacg ctgagcaaag cagactacga gaaacacaaa 1320
gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa gagcttcaac 1380
aggggagag                                                         1389

<210> 68
<211> 463
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0167

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 68
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
                 1               5                  10          
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
        15                  20                  25              
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
    30                  35                  40                  
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
45                  50                  55                  60  
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
                65                  70                  75      
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
            80                  85                  90          
Asn Thr Lys Val Asp Lys Lys Val Arg Thr Glu Pro Lys Ser Ser Asp
        95                  100                 105             
Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu Leu
    110                 115                 120                 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
125                 130                 135                 140 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
                145                 150                 155     
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
            160                 165                 170         
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
        175                 180                 185             
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
    190                 195                 200                 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
205                 210                 215                 220 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
                225                 230                 235     
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
            240                 245                 250         
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
        255                 260                 265             
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
    270                 275                 280                 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
285                 290                 295                 300 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
                305                 310                 315     
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
            320                 325                 330         
Ser Pro Gly Lys Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe
        335                 340                 345             
Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys
    350                 355                 360                 
Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val
365                 370                 375                 380 
Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln
                385                 390                 395     
Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser
            400                 405                 410         
Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His
        415                 420                 425             
Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
    430                 435                 440             


<210> 69
<211> 2199
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0168

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 69
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 120
actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg 180
aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc 240
aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa 300
cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 360
ttcaacaggg gagagcgtac ggagcccaaa tcttctgaca aaactcacac atgcccaccg 420
tgcccatccg gagcacctga actcctgggt ggaccgtcag tcttcctctt ccccccaaaa 480
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 540
agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 600
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 660
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 720
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 780
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 840
tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag 900
ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 960
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 1020
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 1080
aaatctagag cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc 1140
acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgagccggtg 1200
acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta 1260
cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc 1320
acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa 1380
gttaactcat tattcaacca agaagttcaa attcccttga ccgaaagtta cagcccgaat 1440
tctcaggtgc agctgaagga gtcaggacct ggcagcgtgg cgccctcaca gagcctgtcc 1500
atcacatgca ccgtctcagg gttctcatta accggctatg gtgtaaactg ggttcgccag 1560
cctccaggaa agggtctgga gtggctggga atgatatggg gtgatggaag cacagactat 1620
aattcagctc tcaaatccag actatcgatc accaaggaca actccaagag ccaagttttc 1680
ttaaaaatga acagtctgca aactgatgac acagccagat actactgtgc tcgggatggt 1740
tatagtaact ttcattacta tgttatggac tactggggtc aaggaacctc agtcaccgtc 1800
tcctctgggg gtggaggctc tggtggcggt ggatccggcg gaggtgggtc gggtggcggc 1860
ggatctgaca ttgtgctcac ccaatctcca gcttctttgg ctgtgtctct aggtcagaga 1920
gccaccatct cctgcagagc cagtgaaagt gttgaatatt atgtcacaag tttaatgcag 1980
tggtaccaac agaaaccagg acagccaccc aaactcctca tctctgctgc tagcaacgta 2040
gaatctgggg tccctgccag gtttagtggc agtgggtctg ggacagactt tagcctcaac 2100
atccatcctg tggaggagga tgatattgca atgtatttct gtcagcaaag taggaaggtt 2160
ccatggacgt tcggtggagg caccaagctg gaaatcaag                        2199

<210> 70
<211> 733
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0168

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 70
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
                 1               5                  10          
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
        15                  20                  25              
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
    30                  35                  40                  
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
45                  50                  55                  60  
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
                65                  70                  75      
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
            80                  85                  90          
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu
        95                  100                 105             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly
    110                 115                 120                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
125                 130                 135                 140 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                145                 150                 155     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            160                 165                 170         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        175                 180                 185             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    190                 195                 200                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
205                 210                 215                 220 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                225                 230                 235     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            240                 245                 250         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        255                 260                 265             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    270                 275                 280                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
285                 290                 295                 300 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                305                 310                 315     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            320                 325                 330         
Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Ala Ser Thr Lys Gly
        335                 340                 345             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    350                 355                 360                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
365                 370                 375                 380 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                385                 390                 395     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            400                 405                 410         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        415                 420                 425             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Asn Ser Leu
    430                 435                 440                 
Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn
445                 450                 455                 460 
Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Ser Val Ala Pro Ser
                465                 470                 475     
Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly
            480                 485                 490         
Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp
        495                 500                 505             
Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu
    510                 515                 520                 
Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe
525                 530                 535                 540 
Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys
                545                 550                 555     
Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met Asp Tyr Trp
            560                 565                 570         
Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
        575                 580                 585             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
    590                 595                 600                 
Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
605                 610                 615                 620 
Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr
                625                 630                 635     
Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu
            640                 645                 650         
Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe
        655                 660                 665             
Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val
    670                 675                 680                 
Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys Val
685                 690                 695                 700 
Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
                705                 710             


<210> 71
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) mature protein without the signal
      peptide

<400> 71
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 72
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) N29A mature protein without the
      signal peptide

<400> 72
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 73
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) N30A mature protein without the
      signal peptide

<400> 73
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Ala Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 74
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) Q52A mature protein without the
      signal peptide

<400> 74
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Ala Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 75
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) V55A mature protein without the
      signal peptide

<400> 75
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 76
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) T56A mature protein without the
      signal peptide

<400> 76
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Ala Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 77
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) S68A mature protein without the
      signal peptide

<400> 77
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ala Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 78
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) T70A mature protein without the
      signal peptide

<400> 78
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 79
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) V55A N29A mature protein without
      the signal peptide

<400> 79
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 80
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) V55A N30A mature protein without
      the signal peptide

<400> 80
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Ala Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 81
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) V55A Q52A mature protein without
      the signal peptide

<400> 81
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Ala Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 82
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) V55A T56A mature protein without
      the signal peptide

<400> 82
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Ala Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 83
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) V55A S68A mature protein without
      the signal peptide

<400> 83
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ala Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 84
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) V55A T70A mature protein without
      the signal peptide

<400> 84
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 85
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) V55A N29A N30A mature protein
      without the signal peptide

<400> 85
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 86
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) V55A N29A S68A mature protein
      without the signal peptide

<400> 86
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ala Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 87
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) V55A S68A T70A mature protein
      without the signal peptide

<400> 87
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ala Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 88
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) V55A Q52A S68A mature protein
      without the signal peptide

<400> 88
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Ala Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ala Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 89
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) N29R V55A T70A mature protein
      without the signal peptide

<400> 89
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Arg Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 90
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) N29K V55A T70A  mature protein
      without the signal peptide

<400> 90
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Lys Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 91
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) N29W V55A T70A mature protein
      without the signal peptide

<400> 91
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Trp Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 92
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) N29Y V55A T70A mature protein
      without the signal peptide

<400> 92
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Tyr Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 93
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) S8K V55A mature protein without
      the signal peptide

<400> 93
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Lys Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 94
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) S68E V55A mature protein without
      the signal peptide

<400> 94
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Glu Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 95
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) S68Q V55A mature protein without
      the signal peptide

<400> 95
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Gln Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 96
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) T70E V55A mature protein without
      the signal peptide

<400> 96
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 97
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) Q52L N29A N30A mature protein
      without the signal peptide

<400> 97
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Leu Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 98
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) N30R V55A T70A mature protein
      without the signal peptide

<400> 98
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Arg Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 99
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) N30K V55A T70A mature protein
      without the signal peptide

<400> 99
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Lys Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 100
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) N30W V55A T70A mature protein
      without the signal peptide

<400> 100
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Trp Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 101
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) N30E V55A T70A mature protein
      without the signal peptide

<400> 101
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Glu Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 102
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) N30G V55A T70A mature protein
      without the signal peptide

<400> 102
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Gly Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 103
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) V55R N29A N30A mature protein
      without the signal peptide

<400> 103
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Arg Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 104
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) V55W N29A N30Amature protein
      without the signal peptide

<400> 104
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Trp Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 105
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) V55E N29A N30A mature protein
      without the signal peptide

<400> 105
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Glu Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 106
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH of 2E12 scFv

<400> 106
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Ser Val Ala Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr
            20                  25                  30          
Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala
                85                  90                  95      
Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Ser Val Thr Val Ser Ser
        115                 120     


<210> 107
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL of 2E12 scFv

<400> 107
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr
            20                  25                  30          
Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65                  70                  75                  80  
Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg
                85                  90                  95      
Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110     


<210> 108
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker of 2E12 scFv

<400> 108
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
 1               5                  10                  15      
Gly Gly Gly Ser
            20  


<210> 109
<211> 252
<212> PRT
<213> Artificial Sequence

<220> 
<223> full length 2E12 scFv

<400> 109
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Ser Val Ala Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr
            20                  25                  30          
Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala
                85                  90                  95      
Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val
    130                 135                 140                 
Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala
145                 150                 155                 160 
Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser
                165                 170                 175     
Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu
            180                 185                 190         
Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser
        195                 200                 205             
Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu
    210                 215                 220                 
Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro
225                 230                 235                 240 
Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
                245                 250         


<210> 110
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Signal peptide of 2E12 scFv

<400> 110
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser
 1               5                  10                  15      
Val Ile Met Ser Arg Gly
            20          


<210> 111
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Signal peptide in various signle chain fusion
      proteins (X01xx)

<400> 111
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
 1               5                  10                  15      
Asp Thr Thr Gly
            20  


<210> 112
<211> 107
<212> PRT
<213> Homo sapiens

<400> 112
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
 1               5                  10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105         


<210> 113
<211> 106
<212> PRT
<213> Homo sapiens

<400> 113
Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser
 1               5                  10                  15      
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp
            20                  25                  30          
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro
        35                  40                  45              
Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn
    50                  55                  60                  
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys
65                  70                  75                  80  
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val
                85                  90                  95      
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
            100                 105     


<210> 114
<211> 98
<212> PRT
<213> Homo sapiens

<400> 114
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val
        


<210> 115
<211> 110
<212> PRT
<213> Homo sapiens

<400> 115
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            100                 105                 110 


<210> 116
<211> 107
<212> PRT
<213> Homo sapiens

<400> 116
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
 1               5                  10                  15      
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
65                  70                  75                  80  
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            100                 105         


<210> 117
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) Q52R mature protein without the
      signal peptide

<400> 117
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Trp Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 118
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) Q52W mature protein without the
      signal peptide

<400> 118
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Trp Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 119
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) T56R mature protein without the
      signal peptide

<400> 119
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Arg Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 120
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) T56W mature protein without the
      signal peptide

<400> 120
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Trp Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 121
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) S68R mature protein without the
      signal peptide

<400> 121
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Arg Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 122
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) S68W mature protein without the
      signal peptide

<400> 122
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Trp Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 123
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) T70R mature protein without the
      signal peptide

<400> 123
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Arg Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 124
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113 (CkCH2CH3) T70W mature protein without the
      signal peptide

<400> 124
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Trp Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 125
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> NKG2D Linker

<400> 125
Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr
 1               5                  10                  15      
Ser Pro Asn Ser
            20  


<210> 126
<211> 1083
<212> DNA
<213> Artificial Sequence

<220> 
<223>  X0229 (Ck WYAE (N29W N30Y V55A T70E) CH2 CH3

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 126
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 120
actgcctctg ttgtgtgcct gctgtggtac ttctatccca gagaggccaa agtacagtgg 180
aaggtggata acgccctcca atcgggtaac tcccaggaga gtgccacaga gcaggacagc 240
aaggacagca cctacagcct cagcagcgag ctgacgctga gcaaagcaga ctacgagaaa 300
cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 360
ttcaacaggg gagagcgtac ggagcccaaa tcttctgaca aaactcacac atgcccaccg 420
tgcccatccg gagcacctga actcctgggt ggaccgtcag tcttcctctt ccccccaaaa 480
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 540
agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 600
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 660
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 720
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 780
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 840
tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag 900
ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 960
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 1020
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 1080
aaa                                                               1083

<210> 127
<211> 361
<212> PRT
<213> Artificial Sequence

<220> 
<223>  X0229 (Ck WYAE (N29W N30Y V55A T70E) CH2 CH3

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 127
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
                 1               5                  10          
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
        15                  20                  25              
Trp Tyr Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
    30                  35                  40                  
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser
45                  50                  55                  60  
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala
                65                  70                  75      
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
            80                  85                  90          
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu
        95                  100                 105             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly
    110                 115                 120                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
125                 130                 135                 140 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                145                 150                 155     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            160                 165                 170         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        175                 180                 185             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    190                 195                 200                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
205                 210                 215                 220 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                225                 230                 235     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            240                 245                 250         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        255                 260                 265             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    270                 275                 280                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
285                 290                 295                 300 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                305                 310                 315     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            320                 325                 330         
Lys Ser Leu Ser Leu Ser Pro Gly Lys
        335                 340     


<210> 128
<211> 1083
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0231 (Ck YYAE (N29Y N30Y V55A T70E) CH2 CH3)

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 128
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 120
actgcctctg ttgtgtgcct gctgtactac ttctatccca gagaggccaa agtacagtgg 180
aaggtggata acgccctcca atcgggtaac tcccaggaga gtgccacaga gcaggacagc 240
aaggacagca cctacagcct cagcagcgag ctgacgctga gcaaagcaga ctacgagaaa 300
cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 360
ttcaacaggg gagagcgtac ggagcccaaa tcttctgaca aaactcacac atgcccaccg 420
tgcccatccg gagcacctga actcctgggt ggaccgtcag tcttcctctt ccccccaaaa 480
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 540
agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 600
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 660
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 720
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 780
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 840
tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag 900
ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 960
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 1020
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 1080
aaa                                                               1083

<210> 129
<211> 361
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0231 (Ck YYAE (N29Y N30Y V55A T70E) CH2 CH3)

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 129
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
                 1               5                  10          
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
        15                  20                  25              
Tyr Tyr Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
    30                  35                  40                  
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser
45                  50                  55                  60  
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala
                65                  70                  75      
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
            80                  85                  90          
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu
        95                  100                 105             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly
    110                 115                 120                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
125                 130                 135                 140 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                145                 150                 155     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            160                 165                 170         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        175                 180                 185             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    190                 195                 200                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
205                 210                 215                 220 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                225                 230                 235     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            240                 245                 250         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        255                 260                 265             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    270                 275                 280                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
285                 290                 295                 300 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                305                 310                 315     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            320                 325                 330         
Lys Ser Leu Ser Leu Ser Pro Gly Lys
        335                 340     


<210> 130
<211> 1083
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0193 (Ck EAE (N30E V55A T70E) CH2 CH3)

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 130
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 120
actgcctctg ttgtgtgcct gctgaatgag ttctatccca gagaggccaa agtacagtgg 180
aaggtggata acgccctcca atcgggtaac tcccaggaga gtgccacaga gcaggacagc 240
aaggacagca cctacagcct cagcagcgag ctgacgctga gcaaagcaga ctacgagaaa 300
cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 360
ttcaacaggg gagagcgtac ggagcccaaa tcttctgaca aaactcacac atgcccaccg 420
tgcccatccg gagcacctga actcctgggt ggaccgtcag tcttcctctt ccccccaaaa 480
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 540
agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 600
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 660
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 720
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 780
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 840
tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag 900
ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 960
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 1020
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 1080
aaa                                                               1083

<210> 131
<211> 361
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0193 (Ck EAE (N30E V55A T70E) CH2 CH3)

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 131
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
                 1               5                  10          
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
        15                  20                  25              
Asn Glu Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
    30                  35                  40                  
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser
45                  50                  55                  60  
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala
                65                  70                  75      
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
            80                  85                  90          
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu
        95                  100                 105             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly
    110                 115                 120                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
125                 130                 135                 140 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                145                 150                 155     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            160                 165                 170         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        175                 180                 185             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    190                 195                 200                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
205                 210                 215                 220 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                225                 230                 235     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            240                 245                 250         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        255                 260                 265             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    270                 275                 280                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
285                 290                 295                 300 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                305                 310                 315     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            320                 325                 330         
Lys Ser Leu Ser Leu Ser Pro Gly Lys
        335                 340     


<210> 132
<211> 1083
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0220 (Ck YAE (N30Y V55A T70E) CH2 CH3)

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 132
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 120
actgcctctg ttgtgtgcct gctgaattac ttctatccca gagaggccaa agtacagtgg 180
aaggtggata acgccctcca atcgggtaac tcccaggaga gtgccacaga gcaggacagc 240
aaggacagca cctacagcct cagcagcgag ctgacgctga gcaaagcaga ctacgagaaa 300
cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 360
ttcaacaggg gagagcgtac ggagcccaaa tcttctgaca aaactcacac atgcccaccg 420
tgcccatccg gagcacctga actcctgggt ggaccgtcag tcttcctctt ccccccaaaa 480
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 540
agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 600
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 660
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 720
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 780
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 840
tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag 900
ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 960
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 1020
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 1080
aaa                                                               1083

<210> 133
<211> 361
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0220 (Ck YAE (N30Y V55A T70E) CH2 CH3)

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 133
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
                 1               5                  10          
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
        15                  20                  25              
Asn Tyr Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
    30                  35                  40                  
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser
45                  50                  55                  60  
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala
                65                  70                  75      
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
            80                  85                  90          
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu
        95                  100                 105             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly
    110                 115                 120                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
125                 130                 135                 140 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                145                 150                 155     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            160                 165                 170         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        175                 180                 185             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    190                 195                 200                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
205                 210                 215                 220 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                225                 230                 235     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            240                 245                 250         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        255                 260                 265             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    270                 275                 280                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
285                 290                 295                 300 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                305                 310                 315     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            320                 325                 330         
Lys Ser Leu Ser Leu Ser Pro Gly Lys
        335                 340     


<210> 134
<211> 1785
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0234 (P2C2 CH1 CH2 CH3)

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 134
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
gatattgtga tgatccagga tgaactctcc aatcctgtca gttctggaga atcagtttcc 120
atctcctgta ggtctagtaa gagtctccta gataaggaag ggaagacata cttgaattgg 180
tttctgcaga gaccaggaca atctcctcag ctcctgatct atctgatgtc catgcgtgaa 240
tcaggagtct cagaccggtt tagtggcagt gggtcaggaa cagatttcac cctggaaatc 300
agtagagtga aggctgagga tgtgggtgtg tattactgtc aacaacttgt agagtatccg 360
tggacgttcg gtggaggcac caagctggaa atcaaaggtg gcggtggctc tggcggaggt 420
ggatccggtg gcggcggctc tcagatccag ttggtgcagt ctggacctga gctgaagaag 480
cctggagaga cagtcaagat ctcctgcaag gcttctggtt ataccttcac agacttttca 540
atgcactggg tgaggcaggc tccaggaaag ggtttaaagt ggatgggctg gataaacact 600
gagactggtg agccaacata tgcagatgac ttcaggggac ggtttgcctt ctctttggaa 660
acttctgcca gcactgccta tttgcagatc aacaacctca aaaatgagga cacggctaca 720
tatttttgta cctggtctgc ttactggggc caagggactc tggtcactgt ctctgcctcg 780
agcgcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct 840
gggggcacag cggccctggg ctgcctggtc aaggactact tccccgagcc ggtgacggtg 900
tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc 960
tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag 1020
acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttcgt 1080
acggagccca aatcttctga caaaactcac acatgcccac cgtgcccatc cggagcacct 1140
gaactcctgg gtggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg 1200
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag 1260
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg 1320
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac 1380
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc 1440
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc 1500
ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc 1560
tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag 1620
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg 1680
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg 1740
cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                 1785

<210> 135
<211> 595
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0234 (P2C2 CH1 CH2 CH3)

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 135
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Asp Ile Val Met Ile Gln Asp Glu Leu Ser Asn Pro
                 1               5                  10          
Val Ser Ser Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser
        15                  20                  25              
Leu Leu Asp Lys Glu Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg
    30                  35                  40                  
Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Met Ser Met Arg Glu
45                  50                  55                  60  
Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                65                  70                  75      
Thr Leu Glu Ile Ser Arg Val Lys Ala Glu Asp Val Gly Val Tyr Tyr
            80                  85                  90          
Cys Gln Gln Leu Val Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys
        95                  100                 105             
Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
    110                 115                 120                 
Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys
125                 130                 135                 140 
Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe
                145                 150                 155     
Thr Asp Phe Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
            160                 165                 170         
Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala
        175                 180                 185             
Asp Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser
    190                 195                 200                 
Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr
205                 210                 215                 220 
Tyr Phe Cys Thr Trp Ser Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
                225                 230                 235     
Val Ser Ala Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu
            240                 245                 250         
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys
        255                 260                 265             
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
    270                 275                 280                 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser
285                 290                 295                 300 
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
                305                 310                 315     
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn
            320                 325                 330         
Thr Lys Val Asp Lys Lys Val Arg Thr Glu Pro Lys Ser Ser Asp Lys
        335                 340                 345             
Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly
    350                 355                 360                 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
365                 370                 375                 380 
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
                385                 390                 395     
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
            400                 405                 410         
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
        415                 420                 425             
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
    430                 435                 440                 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
445                 450                 455                 460 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
                465                 470                 475     
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
            480                 485                 490         
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
        495                 500                 505             
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
    510                 515                 520                 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
525                 530                 535                 540 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                545                 550                 555     
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
            560                 565                 570         
Pro Gly Lys
        575 


<210> 136
<211> 1089
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0225 (CH2 CH3 Ck YAE (N30Y V55A T70E)

<220> 
<221> sig_peptide    
<222> (1)...(60)

<400> 136
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
tcctcggagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc atccggagca 120
cctgaactcc tgggtggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc 180
atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct 240
gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg 300
cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag 360
gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc 420
atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg 480
cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc 540
ttctatccaa gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac 600
aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc 660
gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct 720
ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatc tagaactgtg 780
gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc tggaactgcc 840
tctgttgtgt gcctgctgaa ttacttctat cccagagagg ccaaagtaca gtggaaggtg 900
gataacgccc tccaatcggg taactcccag gagagtgcca cagagcagga cagcaaggac 960
agcacctaca gcctcagcag cgagctgacg ctgagcaaag cagactacga gaaacacaaa 1020
gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa gagcttcaac 1080
aggggagag                                                         1089

<210> 137
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0225 (CH2 CH3 Ck YAE (N30Y V55A T70E)

<220> 
<221> SIGNAL         
<222> (1)...(20)

<400> 137
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
-20                 -15                 -10                 -5  
Asp Thr Thr Gly Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr
                 1               5                  10          
Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro Ser
        15                  20                  25              
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    30                  35                  40                  
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
45                  50                  55                  60  
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                65                  70                  75      
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
            80                  85                  90          
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        95                  100                 105             
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
    110                 115                 120                 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
125                 130                 135                 140 
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
                145                 150                 155     
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            160                 165                 170         
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        175                 180                 185             
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
    190                 195                 200                 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
205                 210                 215                 220 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                225                 230                 235     
Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
            240                 245                 250         
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Tyr
        255                 260                 265             
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
    270                 275                 280                 
Gln Ser Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp
285                 290                 295                 300 
Ser Thr Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr
                305                 310                 315     
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
            320                 325                 330         
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
        335                 340             


<210> 138
<211> 2127
<212> DNA
<213> Artificial Sequence

<220> 
<223> 5D5 scFv CH1 CH2 CH3 Ck

<400> 138
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
gactttatga tgtcacagtc tccatcctcc ctaactgtgt cagttggaga gaaggttact 120
gtgagctgca agtccagtca gtccctttta tatactagca gtcagaagaa ctacttggcc 180
tggtaccagc agaaaccagg tcagtctcct aaactgctga tttactgggc atccactagg 240
gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc 300
atcaccagtg tgaaggctga cgacctggca gtttattact gtcagcaata ttatgcctat 360
ccgtggacgt tcggtggagg caccaagttg gagctcaaag gtggcggtgg ctctggcgga 420
ggtggatccg gtggcggcgg ctctcaggtc caactgcagc agtctgggcc tgagctggtg 480
aggcctgggg cttcagtgaa gatgtcctgc agggcttcgg gctatacctt caccagctac 540
tggttgcact gggttaaaca gaggcctgga caaggccttg agtggattgg catgattgat 600
ccttccaata gtgacactag gtttaatccg aacttcaagg acaaggccac attgaatgta 660
gacagatctt ccaacacagc ctacatgctg ctcagcagcc tgacatctgc tgactctgca 720
gtctattact gtgccacata tggtagctac gtttcccctc tggactactg gggtcaagga 780
acctcagtca ccgtctcctc gagcgcctcc accaagggcc catcggtctt ccccctggca 840
ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac 900
ttccccgagc cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc 960
ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc 1020
tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc 1080
aaggtggaca agaaagttcg tacggagccc aaatcttctg acaaaactca cacatgccca 1140
ccgtgcccat ccggagcacc tgaactcctg ggtggaccgt cagtcttcct cttcccccca 1200
aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac 1260
gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat 1320
aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc 1380
ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac 1440
aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa 1500
ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg 1560
acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg 1620
cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc 1680
ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc 1740
tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg 1800
ggtaaatcta gaactgtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag 1860
ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc 1920
aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca 1980
gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca 2040
gactacgaga aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc 2100
gtcacaaaga gcttcaacag gggagag                                     2127

<210> 139
<211> 689
<212> PRT
<213> Artificial Sequence

<220> 
<223> 5D5 scFv CH1 CH2 CH3 Ck

<400> 139
Asp Phe Met Met Ser Gln Ser Pro Ser Ser Leu Thr Val Ser Val Gly
 1               5                  10                  15      
Glu Lys Val Thr Val Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr
            20                  25                  30          
Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Thr Ser Val Lys Ala Asp Asp Leu Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Tyr Ala Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu
            100                 105                 110         
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        115                 120                 125             
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala
    130                 135                 140                 
Ser Val Lys Met Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
145                 150                 155                 160 
Trp Leu His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
                165                 170                 175     
Gly Met Ile Asp Pro Ser Asn Ser Asp Thr Arg Phe Asn Pro Asn Phe
            180                 185                 190         
Lys Asp Lys Ala Thr Leu Asn Val Asp Arg Ser Ser Asn Thr Ala Tyr
        195                 200                 205             
Met Leu Leu Ser Ser Leu Thr Ser Ala Asp Ser Ala Val Tyr Tyr Cys
    210                 215                 220                 
Ala Thr Tyr Gly Ser Tyr Val Ser Pro Leu Asp Tyr Trp Gly Gln Gly
225                 230                 235                 240 
Thr Ser Val Thr Val Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
                245                 250                 255     
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
            260                 265                 270         
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
        275                 280                 285             
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
    290                 295                 300                 
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
305                 310                 315                 320 
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
                325                 330                 335     
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Arg Thr Glu Pro Lys Ser
            340                 345                 350         
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu
        355                 360                 365             
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
    370                 375                 380                 
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
385                 390                 395                 400 
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
                405                 410                 415     
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
            420                 425                 430         
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
        435                 440                 445             
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
    450                 455                 460                 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
465                 470                 475                 480 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
                485                 490                 495     
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
            500                 505                 510         
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
        515                 520                 525             
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
    530                 535                 540                 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
545                 550                 555                 560 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
                565                 570                 575     
Ser Leu Ser Pro Gly Lys Ser Arg Thr Val Ala Ala Pro Ser Val Phe
            580                 585                 590         
Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val
        595                 600                 605             
Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp
    610                 615                 620                 
Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr
625                 630                 635                 640 
Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr
                645                 650                 655     
Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val
            660                 665                 670         
Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly
        675                 680                 685             
Glu
        


<210> 140
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Cl sequence used in constructing
      Interceptors

<400> 140
Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu
 1               5                  10                  15      
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe
            20                  25                  30          
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val
        35                  40                  45              
Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys
    50                  55                  60                  
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser
65                  70                  75                  80  
His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu
                85                  90                  95      
Lys Thr Val Ala Pro Thr Glu Ser Ser
            100                 105 


<210> 141
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck sequence used in constructing
      Interceptors

<400> 141
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 142
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with N29A substitution

<400> 142
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 143
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with N30A substitution

<400> 143
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Ala Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 144
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with Q52A substitution

<400> 144
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Ala Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 145
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with V55A substitution

<400> 145
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 146
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with T56A substitution

<400> 146
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Ala Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 147
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with S68A substitution

<400> 147
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ala Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 148
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with T70A substitution

<400> 148
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 149
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with V55A N29A substitution

<400> 149
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 150
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with V55A N30A substitution

<400> 150
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Ala Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 151
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with V55A Q52A substitution

<400> 151
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Ala Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 152
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with V55A S68A substitution

<400> 152
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ala Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 153
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with V55A T70A substitution

<400> 153
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 154
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with V55A N29A N30A substitution

<400> 154
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 155
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with V55A N29A S68A substitution

<400> 155
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ala Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 156
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with V55A S68A T70A substitution

<400> 156
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ala Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 157
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with V55A Q52A S68A substitution

<400> 157
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Ala Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ala Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 158
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with N29R V55A T70A substitution

<400> 158
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Arg Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 159
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with N29AK V55A T70A substitution

<400> 159
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Lys Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 160
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with N29W V55A T70A substitution

<400> 160
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Trp Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 161
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with N29Y V55A T70A substitution

<400> 161
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Tyr Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 162
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with S68K V55A substitution

<400> 162
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Lys Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 163
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with S68E V55A substitution

<400> 163
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Glu Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 164
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with S68Q V55A substitution

<400> 164
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Gln Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 165
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with T70E V55A substitution

<400> 165
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 166
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with Q52L N29A N30A substitution

<400> 166
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Leu Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 167
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with N30R V55A T70A substitution

<400> 167
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Arg Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 168
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with N30K V55A T70A substitution

<400> 168
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Lys Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 169
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with N30W V55A T70A substitution

<400> 169
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Trp Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 170
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with N30E V55A T70A substitution

<400> 170
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Glu Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 171
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with N30G V55A T70A substitution

<400> 171
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Gly Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 172
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with V55R N29A N30A substitution

<400> 172
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Arg Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 173
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with V55W N29A N30A substitution

<400> 173
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Trp Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 174
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with V55E N29A N30A substitution

<400> 174
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Glu Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 175
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with N29W N30Y V55A T70E (WYAE)
      substitution

<400> 175
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Trp Tyr Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 176
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with N29Y N30Y V55A T70E (YYAE)
      substitution

<400> 176
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Tyr Tyr Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 177
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with N30E V55A T70E (EAE)
      substitution

<400> 177
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Glu Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 178
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck with N30Y V55A T70E (YAE)
      substitution

<400> 178
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Tyr Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 179

<400> 179
 000

<210> 180
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human IgG1 SSS-P hinge

<400> 180
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro
 1               5                  10                  15  


<210> 181
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human IgG1 SCC-P hinge

<400> 181
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15  


<210> 182
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL of P2C2 scFv

<400> 182
Asp Ile Val Met Ile Gln Asp Glu Leu Ser Asn Pro Val Ser Ser Gly
 1               5                  10                  15      
Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asp Lys
            20                  25                  30          
Glu Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Met Ser Met Arg Glu Ser Gly Val Ser
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile
65                  70                  75                  80  
Ser Arg Val Lys Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Leu
                85                  90                  95      
Val Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 183
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker of P2C2 scFv

<400> 183
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 184
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH of P2C2 scFv

<400> 184
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Phe
            20                  25                  30          
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe
    50                  55                  60                  
Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
                85                  90                  95      
Thr Trp Ser Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala
            100                 105                 110         


<210> 185
<211> 239
<212> PRT
<213> Artificial Sequence

<220> 
<223> full length of P2C2 scFv

<400> 185
Asp Ile Val Met Ile Gln Asp Glu Leu Ser Asn Pro Val Ser Ser Gly
 1               5                  10                  15      
Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asp Lys
            20                  25                  30          
Glu Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Met Ser Met Arg Glu Ser Gly Val Ser
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile
65                  70                  75                  80  
Ser Arg Val Lys Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Leu
                85                  90                  95      
Val Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln
        115                 120                 125             
Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr
    130                 135                 140                 
Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Phe Ser
145                 150                 155                 160 
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly
                165                 170                 175     
Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Arg
            180                 185                 190         
Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu
        195                 200                 205             
Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Thr
    210                 215                 220                 
Trp Ser Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala
225                 230                 235                 


<210> 186
<211> 102
<212> PRT
<213> Homo sapiens

<400> 186
Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr
 1               5                  10                  15      
Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe
            20                  25                  30          
Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val
        35                  40                  45              
Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr
    50                  55                  60                  
Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly
65                  70                  75                  80  
Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp
                85                  90                  95      
Val Thr Val Pro Cys Pro
            100         


<210> 187
<211> 102
<212> PRT
<213> Homo sapiens

<400> 187
Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr
 1               5                  10                  15      
Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe
            20                  25                  30          
Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val
        35                  40                  45              
Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr
    50                  55                  60                  
Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly
65                  70                  75                  80  
Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp
                85                  90                  95      
Val Thr Val Pro Cys Pro
            100         


<210> 188
<211> 101
<212> PRT
<213> Homo sapiens

<400> 188
Ala Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg
 1               5                  10                  15      
His Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly
            20                  25                  30          
Tyr His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser
        35                  40                  45              
Gln Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr
    50                  55                  60                  
Met Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly
65                  70                  75                  80  
Glu Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu
                85                  90                  95      
Ile Phe Arg Trp Pro
            100     


<210> 189
<211> 103
<212> PRT
<213> Homo sapiens

<400> 189
Ala Ser Thr Gln Ser Pro Ser Val Phe Pro Leu Thr Arg Cys Cys Lys
 1               5                  10                  15      
Asn Ile Pro Ser Asn Ala Thr Ser Val Thr Leu Gly Cys Leu Ala Thr
            20                  25                  30          
Gly Tyr Phe Pro Glu Pro Val Met Val Thr Cys Asp Thr Gly Ser Leu
        35                  40                  45              
Asn Gly Thr Thr Met Thr Leu Pro Ala Thr Thr Leu Thr Leu Ser Gly
    50                  55                  60                  
His Tyr Ala Thr Ile Ser Leu Leu Thr Val Ser Gly Ala Trp Ala Lys
65                  70                  75                  80  
Gln Met Phe Thr Cys Arg Val Ala His Thr Pro Ser Ser Thr Asp Trp
                85                  90                  95      
Val Asp Asn Lys Thr Phe Ser
            100             


<210> 190
<211> 98
<212> PRT
<213> Homo sapiens

<400> 190
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Thr Val
        


<210> 191
<211> 98
<212> PRT
<213> Homo sapiens

<400> 191
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val
        


<210> 192
<211> 98
<212> PRT
<213> Homo sapiens

<400> 192
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val
        


<210> 193
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0113(CkCH2CH3) T70E, N29A, N30A, V55A mature
      protein without the signal peptide

<400> 193
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Arg Thr Glu Pro Lys Ser Ser
            100                 105                 110         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu
        115                 120                 125             
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
    130                 135                 140                 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
145                 150                 155                 160 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
                165                 170                 175     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
            180                 185                 190         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
        195                 200                 205             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
    210                 215                 220                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
225                 230                 235                 240 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
                245                 250                 255     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
            260                 265                 270         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
        275                 280                 285             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
    290                 295                 300                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
305                 310                 315                 320 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                325                 330                 335     
Leu Ser Pro Gly Lys
            340     


<210> 194
<211> 104
<212> PRT
<213> Homo sapiens

<400> 194
Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn
 1               5                  10                  15      
Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp
            20                  25                  30          
Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser
        35                  40                  45              
Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys
    50                  55                  60                  
Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln
65                  70                  75                  80  
Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn
                85                  90                  95      
Lys Glu Lys Asn Val Pro Leu Pro
            100                 


<210> 195
<211> 101
<212> PRT
<213> Homo sapiens

<400> 195
Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu
 1               5                  10                  15      
Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg
            20                  25                  30          
Asp Ala Ser Gly Val Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser
        35                  40                  45              
Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val
    50                  55                  60                  
Ser Ser Val Leu Pro Gly Cys Ala Glu Pro Trp Asn His Gly Lys Thr
65                  70                  75                  80  
Phe Thr Cys Thr Ala Ala Tyr Pro Glu Ser Lys Thr Pro Leu Thr Ala
                85                  90                  95      
Thr Leu Ser Lys Ser
            100     


<210> 196
<211> 101
<212> PRT
<213> Homo sapiens

<400> 196
Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu
 1               5                  10                  15      
Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg
            20                  25                  30          
Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser
        35                  40                  45              
Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val
    50                  55                  60                  
Ser Ser Val Leu Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr
65                  70                  75                  80  
Phe Thr Cys Thr Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala
                85                  90                  95      
Asn Ile Thr Lys Ser
            100     


<210> 197
<211> 108
<212> PRT
<213> Homo sapiens

<400> 197
Glu Cys Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro
 1               5                  10                  15      
Ala Val Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe
            20                  25                  30          
Val Val Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala
        35                  40                  45              
Gly Lys Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His
    50                  55                  60                  
Ser Asn Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser
65                  70                  75                  80  
Leu Trp Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser
                85                  90                  95      
Leu Pro Pro Gln Arg Leu Met Ala Leu Arg Glu Pro
            100                 105             


<210> 198
<211> 107
<212> PRT
<213> Homo sapiens

<400> 198
Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser
 1               5                  10                  15      
Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys
            20                  25                  30          
Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu
        35                  40                  45              
Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln
    50                  55                  60                  
Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys
65                  70                  75                  80  
His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly
                85                  90                  95      
His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala
            100                 105         


<210> 199
<211> 109
<212> PRT
<213> Homo sapiens

<400> 199
Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
 1               5                  10                  15      
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
            20                  25                  30          
Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
        35                  40                  45              
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
    50                  55                  60                  
Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln
65                  70                  75                  80  
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
                85                  90                  95      
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys
            100                 105                 


<210> 200
<211> 110
<212> PRT
<213> Homo sapiens

<400> 200
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys
            100                 105                 110 


<210> 201
<211> 110
<212> PRT
<213> Homo sapiens

<400> 201
Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
            100                 105                 110 


<210> 202
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human Ck region + T70E, N29A, N30A, V55A

<400> 202
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105 


<210> 203
<211> 112
<212> PRT
<213> Homo sapiens

<400> 203
Val Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg
 1               5                  10                  15      
Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala
            20                  25                  30          
Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly
        35                  40                  45              
Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala
    50                  55                  60                  
Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile
65                  70                  75                  80  
Lys Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp
                85                  90                  95      
His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro
            100                 105                 110         


<210> 204
<211> 131
<212> PRT
<213> Homo sapiens

<400> 204
Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu
 1               5                  10                  15      
Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly
            20                  25                  30          
Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu
        35                  40                  45              
Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser
    50                  55                  60                  
Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala
65                  70                  75                  80  
Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu
                85                  90                  95      
Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly
            100                 105                 110         
Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly
        115                 120                 125             
Thr Cys Tyr
    130     


<210> 205
<211> 131
<212> PRT
<213> Homo sapiens

<400> 205
Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu
 1               5                  10                  15      
Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly
            20                  25                  30          
Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu
        35                  40                  45              
Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser
    50                  55                  60                  
Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala
65                  70                  75                  80  
Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu
                85                  90                  95      
Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly
            100                 105                 110         
Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly
        115                 120                 125             
Thr Cys Tyr
    130     


<210> 206
<211> 117
<212> PRT
<213> Homo sapiens

<400> 206
Ala Ala Gln Ala Pro Val Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser
 1               5                  10                  15      
Asp Pro Pro Glu Ala Ala Ser Trp Leu Leu Cys Glu Val Ser Gly Phe
            20                  25                  30          
Ser Pro Pro Asn Ile Leu Leu Met Trp Leu Glu Asp Gln Arg Glu Val
        35                  40                  45              
Asn Thr Ser Gly Phe Ala Pro Ala Arg Pro Pro Pro Gln Pro Arg Ser
    50                  55                  60                  
Thr Thr Phe Trp Ala Trp Ser Val Leu Arg Val Pro Ala Pro Pro Ser
65                  70                  75                  80  
Pro Gln Pro Ala Thr Tyr Thr Cys Val Val Ser His Glu Asp Ser Arg
                85                  90                  95      
Thr Leu Leu Asn Ala Ser Arg Ser Leu Glu Val Ser Tyr Val Thr Asp
            100                 105                 110         
His Gly Pro Met Lys
        115         


<210> 207
<211> 108
<212> PRT
<213> Homo sapiens

<400> 207
Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro
 1               5                  10                  15      
Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val
            20                  25                  30          
Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala
        35                  40                  45              
Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg
    50                  55                  60                  
Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp
65                  70                  75                  80  
Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu
                85                  90                  95      
Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser
            100                 105             


<210> 208
<211> 107
<212> PRT
<213> Homo sapiens

<400> 208
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
 1               5                  10                  15      
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
65                  70                  75                  80  
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            100                 105         


<210> 209
<211> 107
<212> PRT
<213> Homo sapiens

<400> 209
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
 1               5                  10                  15      
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
65                  70                  75                  80  
Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            100                 105         


<210> 210
<211> 107
<212> PRT
<213> Homo sapiens

<400> 210
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
 1               5                  10                  15      
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
65                  70                  75                  80  
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
            100                 105         


<210> 211
<211> 7
<212> PRT
<213> Homo sapiens

<400> 211
Glu Arg Lys Cys Cys Val Glu
 1               5          


<210> 212
<211> 106
<212> PRT
<213> Homo sapiens

<400> 212
Asp Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala
 1               5                  10                  15      
Ser Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp
            20                  25                  30          
Leu Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly
        35                  40                  45              
Glu Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala
    50                  55                  60                  
Thr Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn
65                  70                  75                  80  
Ser Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser
                85                  90                  95      
Pro Leu Lys Gln Thr Ile Ser Arg Pro Lys
            100                 105     


<210> 213
<211> 110
<212> PRT
<213> Homo sapiens

<400> 213
Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp
 1               5                  10                  15      
Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe
            20                  25                  30          
Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu
        35                  40                  45              
Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser
    50                  55                  60                  
Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu
65                  70                  75                  80  
Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro
                85                  90                  95      
Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys
            100                 105                 110 


<210> 214
<211> 131
<212> PRT
<213> Homo sapiens

<400> 214
Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg
 1               5                  10                  15      
Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr
            20                  25                  30          
Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln
        35                  40                  45              
Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro
    50                  55                  60                  
Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu
65                  70                  75                  80  
Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala His Glu
                85                  90                  95      
Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Gly
            100                 105                 110         
Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly
        115                 120                 125             
Thr Cys Tyr
    130     


<210> 215
<211> 19
<212> PRT
<213> Homo sapiens

<400> 215
Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro
 1               5                  10                  15      
Ser Pro Ser
            


<210> 216
<211> 6
<212> PRT
<213> Homo sapiens

<400> 216
Val Pro Pro Pro Pro Pro
 1               5      


<210> 217
<211> 58
<212> PRT
<213> Homo sapiens

<400> 217
Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln
 1               5                  10                  15      
Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg
            20                  25                  30          
Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu
        35                  40                  45              
Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro
    50                  55              


<210> 218
<211> 15
<212> PRT
<213> Homo sapiens

<400> 218
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15  


<210> 219
<211> 12
<212> PRT
<213> Homo sapiens

<400> 219
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro
 1               5                  10          


<210> 220
<211> 62
<212> PRT
<213> Homo sapiens

<400> 220
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys
 1               5                  10                  15      
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro
            20                  25                  30          
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu
        35                  40                  45              
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro
    50                  55                  60          


<210> 221
<211> 12
<212> PRT
<213> Homo sapiens

<400> 221
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro
 1               5                  10          


<210> 222
<211> 34
<212> PRT
<213> Homo sapiens

<400> 222
Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln
 1               5                  10                  15      
Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg
            20                  25                  30          
Asn Thr
        


<210> 223
<211> 106
<212> PRT
<213> Homo sapiens

<400> 223
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
 1               5                  10                  15      
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp
            20                  25                  30          
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro
        35                  40                  45              
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
    50                  55                  60                  
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys
65                  70                  75                  80  
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val
                85                  90                  95      
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
            100                 105     


<210> 224
<211> 106
<212> PRT
<213> Homo sapiens

<400> 224
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
 1               5                  10                  15      
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp
            20                  25                  30          
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro
        35                  40                  45              
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
    50                  55                  60                  
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys
65                  70                  75                  80  
Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val
                85                  90                  95      
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
            100                 105     


<210> 225
<211> 106
<212> PRT
<213> Homo sapiens

<400> 225
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
 1               5                  10                  15      
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp
            20                  25                  30          
Phe Tyr Pro Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro
        35                  40                  45              
Val Asn Thr Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
    50                  55                  60                  
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys
65                  70                  75                  80  
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val
                85                  90                  95      
Glu Lys Thr Val Ala Pro Ala Glu Cys Ser
            100                 105     


<210> 226
<211> 106
<212> PRT
<213> Homo sapiens

<400> 226
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
 1               5                  10                  15      
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp
            20                  25                  30          
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro
        35                  40                  45              
Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn
    50                  55                  60                  
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys
65                  70                  75                  80  
Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val
                85                  90                  95      
Glu Lys Thr Val Ala Pro Ala Glu Cys Ser
            100                 105     


<210> 227
<211> 10
<212> PRT
<213> Homo sapiens

<400> 227
Glu Pro Lys Ser Cys Asp Lys Thr His Thr
 1               5                  10  


<210> 228
<211> 5
<212> PRT
<213> Homo sapiens

<400> 228
Cys Pro Pro Cys Pro
 1               5  


<210> 229
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human IgG1 hinge (SCC-P)

<400> 229
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15  


<210> 230
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human IgG1 hinge (SSC-P)

<400> 230
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro
 1               5                  10                  15  


<210> 231
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human IgG1 hinge (SSS-P)

<400> 231
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro
 1               5                  10                  15  


<210> 232
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human IgG1 hinge (CSC-P)

<400> 232
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro
 1               5                  10                  15  


<210> 233
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human IgG1 hinge (CSS-P)

<400> 233
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro
 1               5                  10                  15  


<210> 234
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human IgG1 hinge (CCS-P)

<400> 234
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Pro
 1               5                  10                  15  


<210> 235
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human IgG1 hinge (SCC-S)

<400> 235
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser
 1               5                  10                  15  


<210> 236
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human IgG1 hinge (SSC-S)

<400> 236
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser
 1               5                  10                  15  


<210> 237
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human IgG1 hinge (SSS-S)

<400> 237
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Ser
 1               5                  10                  15  


<210> 238
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human IgG1 hinge (CSC-S)

<400> 238
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser
 1               5                  10                  15  


<210> 239
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human IgG1 hinge (CSS-S)

<400> 239
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser
 1               5                  10                  15  


<210> 240
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human IgG1 hinge (CCS-S)

<400> 240
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Ser
 1               5                  10                  15  


<210> 241
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Stalk  region of CD69

<400> 241
Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met
 1               5                  10          


<210> 242
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Stalk  region of CD72

<400> 242
Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys
 1               5                  10      


<210> 243
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Stalk  region of CD94

<400> 243
Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser
 1               5                  10                  15      
Asp Cys
        


<210> 244
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Stalk  region of NKG2A

<400> 244
Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg
 1               5                  10                  15      
His Cys
        


<210> 245
<211> 12
<212> PRT
<213> Homo sapiens

<400> 245
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr
 1               5                  10          


<210> 246
<211> 10
<212> PRT
<213> Homo sapiens

<400> 246
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro
 1               5                  10  


<210> 247
<211> 7
<212> PRT
<213> Homo sapiens

<400> 247
Glu Ser Lys Tyr Gly Pro Pro
 1               5          


<210> 248
<211> 5
<212> PRT
<213> Homo sapiens

<400> 248
Cys Pro Arg Cys Pro
 1               5  


<210> 249
<211> 5
<212> PRT
<213> Homo sapiens

<400> 249
Cys Pro Ser Cys Pro
 1               5  


<210> 250
<211> 17
<212> PRT
<213> Homo sapiens

<400> 250
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys
 1               5                  10                  15      
Pro
    


<210> 251
<211> 15
<212> PRT
<213> Homo sapiens

<400> 251
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro
 1               5                  10                  15  


<210> 252
<211> 24
<212> PRT
<213> Homo sapiens

<400> 252
Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln
 1               5                  10                  15      
Glu Glu Arg Glu Thr Lys Thr Pro
            20                  


<210> 253
<211> 107
<212> PRT
<213> Homo sapiens

<400> 253
Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser
 1               5                  10                  15      
Ser Ser Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys
            20                  25                  30          
Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu
        35                  40                  45              
Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln
    50                  55                  60                  
Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys
65                  70                  75                  80  
His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly
                85                  90                  95      
His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala
            100                 105         


<210> 254
<211> 112
<212> PRT
<213> Homo sapiens

<400> 254
Val Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg
 1               5                  10                  15      
Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala
            20                  25                  30          
Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly
        35                  40                  45              
Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala
    50                  55                  60                  
Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile
65                  70                  75                  80  
Lys Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp
                85                  90                  95      
His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro
            100                 105                 110         


<210> 255
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Altered human CH2 upper hinge like sequence of IgE

<400> 255
Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser
 1               5                  10                  15      
Ser Ser Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys
            20                  25                  30          
Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu
        35                  40                  45              
Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln
    50                  55                  60                  
Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys
65                  70                  75                  80  
His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly
                85                  90                  95      
His Thr Phe Glu Asp Ser Thr Lys Lys Ser Ala
            100                 105         


<210> 256
<211> 268
<212> PRT
<213> Artificial Sequence

<220> 
<223> 5D5 scFv (VLVH)


<400> 256
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
 1               5                  10                  15      
Asp Thr Thr Gly Asp Phe Met Met Ser Gln Ser Pro Ser Ser Leu Thr
            20                  25                  30          
Val Ser Val Gly Glu Lys Val Thr Val Ser Cys Lys Ser Ser Gln Ser
        35                  40                  45              
Leu Leu Tyr Thr Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln
    50                  55                  60                  
Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg
65                  70                  75                  80  
Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp
                85                  90                  95      
Phe Thr Leu Thr Ile Thr Ser Val Lys Ala Asp Asp Leu Ala Val Tyr
            100                 105                 110         
Tyr Cys Gln Gln Tyr Tyr Ala Tyr Pro Trp Thr Phe Gly Gly Gly Thr
        115                 120                 125             
Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
    130                 135                 140                 
Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val
145                 150                 155                 160 
Arg Pro Gly Ala Ser Val Lys Met Ser Cys Arg Ala Ser Gly Tyr Thr
                165                 170                 175     
Phe Thr Ser Tyr Trp Leu His Trp Val Lys Gln Arg Pro Gly Gln Gly
            180                 185                 190         
Leu Glu Trp Ile Gly Met Ile Asp Pro Ser Asn Ser Asp Thr Arg Phe
        195                 200                 205             
Asn Pro Asn Phe Lys Asp Lys Ala Thr Leu Asn Val Asp Arg Ser Ser
    210                 215                 220                 
Asn Thr Ala Tyr Met Leu Leu Ser Ser Leu Thr Ser Ala Asp Ser Ala
225                 230                 235                 240 
Val Tyr Tyr Cys Ala Thr Tyr Gly Ser Tyr Val Ser Pro Leu Asp Tyr
                245                 250                 255     
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ser
            260                 265             
 


<210> 257
<211> 248
<212> PRT
<213> Artificial Sequence

<220> 
<223> 5D5 scFv (VLVH) mature protein without the signal
      peptide

<400> 257
Asp Phe Met Met Ser Gln Ser Pro Ser Ser Leu Thr Val Ser Val Gly
 1               5                  10                  15      
Glu Lys Val Thr Val Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr
            20                  25                  30          
Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Thr Ser Val Lys Ala Asp Asp Leu Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Tyr Ala Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu
            100                 105                 110         
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        115                 120                 125             
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala
    130                 135                 140                 
Ser Val Lys Met Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
145                 150                 155                 160 
Trp Leu His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
                165                 170                 175     
Gly Met Ile Asp Pro Ser Asn Ser Asp Thr Arg Phe Asn Pro Asn Phe
            180                 185                 190         
Lys Asp Lys Ala Thr Leu Asn Val Asp Arg Ser Ser Asn Thr Ala Tyr
        195                 200                 205             
Met Leu Leu Ser Ser Leu Thr Ser Ala Asp Ser Ala Val Tyr Tyr Cys
    210                 215                 220                 
Ala Thr Tyr Gly Ser Tyr Val Ser Pro Leu Asp Tyr Trp Gly Gln Gly
225                 230                 235                 240 
Thr Ser Val Thr Val Ser Ser Ser
                245             


<210> 258
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> 5D5 VH

<400> 258
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Leu His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Met Ile Asp Pro Ser Asn Ser Asp Thr Arg Phe Asn Pro Asn Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Asn Val Asp Arg Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Met Leu Leu Ser Ser Leu Thr Ser Ala Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Thr Tyr Gly Ser Tyr Val Ser Pro Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser Ser
        115                 120


<210> 259
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> 5D5 VL

<400> 259
Asp Phe Met Met Ser Gln Ser Pro Ser Ser Leu Thr Val Ser Val Gly
 1               5                  10                  15      
Glu Lys Val Thr Val Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr
            20                  25                  30          
Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Thr Ser Val Lys Ala Asp Asp Leu Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Tyr Ala Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu
            100                 105                 110         
Lys
    


<210> 260
<211> 792
<212> DNA
<213> Artificial Sequence

<220> 
<223> 4C04 anti-Ron scFv with signal peptide and
      junction amino acids SSS at carboxy-terminus

<400> 260
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
gacattcaga tgacccagtc tcctgcctcc cagtctgcat ctctgggaga aagtgtcacc 120
atcacatgcc tggcaagtca gaccattggt acatggttag catggtatca gcagaaacca 180
gggaaatctc ctcagctcct gatttatgct gcaaccagct tggcagatgg ggtcccatca 240
aggttcagtg ctagtggatc tggcacaaaa ttttctttca agatcgacag cctacagtct 300
gaagattttg taagttatta ctgtcaacaa ctttacaata ctccgtggac gttcggtgga 360
ggcaccaagc tggaaatcaa aggtggcggt ggctctggcg gaggtggatc cggtggcggc 420
ggctctcaga tccagctgca gcagtctgga cctgagctgg tgaagcctgg gacttcagtg 480
aagatatcct gcaaggcttc tgactacaca ctcactgact tctatatgaa ctgggtgagg 540
cagaagcctg gacagggact tgagtggatt gggaggattt atcctggaac cgataaaact 600
agatacaatg agaaattcag ggacaaggcc atactgaccg tggacacgtc ctccagcaca 660
gcctacatgc agctcagcag cctgacatca gaggacactg ctgtctattt ctgtgcaaga 720
tccgcctact atggtaacta cgttgctatg gactactggg gtcaaggaac ctcagtcacc 780
gtctcctcga gc                                                     792

<210> 261
<211> 244
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4C04 anti-Ron scFv with signal peptide and
      junction amino acids SSS at carboxy-terminus

<400> 261
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly
 1               5                  10                  15      
Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Ala
    50                  55                  60                  
Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Asp Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Asn Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Gln Gln
        115                 120                 125             
Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser Val Lys Ile Ser Cys
    130                 135                 140                 
Lys Ala Ser Asp Tyr Thr Leu Thr Asp Phe Tyr Met Asn Trp Val Arg
145                 150                 155                 160 
Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro Gly
                165                 170                 175     
Thr Asp Lys Thr Arg Tyr Asn Glu Lys Phe Arg Asp Lys Ala Ile Leu
            180                 185                 190         
Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu
        195                 200                 205             
Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Ser Ala Tyr Tyr
    210                 215                 220                 
Gly Asn Tyr Val Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr
225                 230                 235                 240 
Val Ser Ser Ser
                


<210> 262
<211> 2115
<212> DNA
<213> Artificial Sequence

<220> 
<223> 4C04 anti-Ron single chain polypeptide (4C04
      scFv-CH1-CH2-CH3-Ck with signal peptide)

<400> 262
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
gacattcaga tgacccagtc tcctgcctcc cagtctgcat ctctgggaga aagtgtcacc 120
atcacatgcc tggcaagtca gaccattggt acatggttag catggtatca gcagaaacca 180
gggaaatctc ctcagctcct gatttatgct gcaaccagct tggcagatgg ggtcccatca 240
aggttcagtg ctagtggatc tggcacaaaa ttttctttca agatcgacag cctacagtct 300
gaagattttg taagttatta ctgtcaacaa ctttacaata ctccgtggac gttcggtgga 360
ggcaccaagc tggaaatcaa aggtggcggt ggctctggcg gaggtggatc cggtggcggc 420
ggctctcaga tccagctgca gcagtctgga cctgagctgg tgaagcctgg gacttcagtg 480
aagatatcct gcaaggcttc tgactacaca ctcactgact tctatatgaa ctgggtgagg 540
cagaagcctg gacagggact tgagtggatt gggaggattt atcctggaac cgataaaact 600
agatacaatg agaaattcag ggacaaggcc atactgaccg tggacacgtc ctccagcaca 660
gcctacatgc agctcagcag cctgacatca gaggacactg ctgtctattt ctgtgcaaga 720
tccgcctact atggtaacta cgttgctatg gactactggg gtcaaggaac ctcagtcacc 780
gtctcctcga gcgcctccac caagggccca tcggtcttcc ccctggcacc ctcctccaag 840
agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgagccg 900
gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc 960
ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg 1020
ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag 1080
aaagttcgta cggagcccaa atcttctgac aaaactcaca catgcccacc gtgcccatcc 1140
ggagcacctg aactcctggg tggaccgtca gtcttcctct tccccccaaa acccaaggac 1200
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 1260
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 1320
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 1380
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 1440
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 1500
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 1560
aaaggcttct atccaagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 1620
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 1680
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 1740
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatctaga 1800
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 1860
actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg 1920
aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc 1980
aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa 2040
cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 2100
ttcaacaggg gagag                                                  2115

<210> 263
<211> 685
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4C04 anti-Ron single chain polypeptide (4C04
      scFv-CH1-CH2-CH3-Ck mature protein without the
      signal peptide)

<400> 263
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly
 1               5                  10                  15      
Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Ala
    50                  55                  60                  
Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Asp Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Asn Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Gln Gln
        115                 120                 125             
Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser Val Lys Ile Ser Cys
    130                 135                 140                 
Lys Ala Ser Asp Tyr Thr Leu Thr Asp Phe Tyr Met Asn Trp Val Arg
145                 150                 155                 160 
Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro Gly
                165                 170                 175     
Thr Asp Lys Thr Arg Tyr Asn Glu Lys Phe Arg Asp Lys Ala Ile Leu
            180                 185                 190         
Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu
        195                 200                 205             
Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Ser Ala Tyr Tyr
    210                 215                 220                 
Gly Asn Tyr Val Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr
225                 230                 235                 240 
Val Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala
                245                 250                 255     
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
            260                 265                 270         
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly
        275                 280                 285             
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
    290                 295                 300                 
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu
305                 310                 315                 320 
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr
                325                 330                 335     
Lys Val Asp Lys Lys Val Arg Thr Glu Pro Lys Ser Ser Asp Lys Thr
            340                 345                 350         
His Thr Cys Pro Pro Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly
        355                 360                 365             
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
    370                 375                 380                 
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
385                 390                 395                 400 
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                405                 410                 415     
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
            420                 425                 430         
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
        435                 440                 445             
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
    450                 455                 460                 
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
465                 470                 475                 480 
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
                485                 490                 495     
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
            500                 505                 510         
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
        515                 520                 525             
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
    530                 535                 540                 
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
545                 550                 555                 560 
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
                565                 570                 575     
Gly Lys Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
            580                 585                 590         
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
        595                 600                 605             
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
    610                 615                 620                 
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
625                 630                 635                 640 
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
                645                 650                 655     
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
            660                 665                 670         
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
        675                 680                 685 


<210> 264
<211> 780
<212> DNA
<213> Artificial Sequence

<220> 
<223> 11H09 anti-RON scFv with signal peptide and
      junction amino acids SSS at carboxy-terminus)

<400> 264
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt 120
ctcacttgtc gggcaagtca ggacattggt agtagcttaa gctggcttca gcaggaacca 180
gatggtacta ttaaacgcct gatctactcc acatccagtt tagattctgg tgtccccaaa 240
aggttcagtg gcagtaggtc ggggtcagat tattctctca ccatcagcag ccttgagtct 300
gaagattttg tagactatta ctgtctacaa tatgctagtt ctccgtggac gttcggtgga 360
ggcaccaagc tggaaatcaa aggtggcggt ggctctggcg gaggtggatc cggtggcggc 420
ggctctcagg tccagcttca gcagtctggg gctgaactgg caaaacctgg ggcctcagtg 480
aagatgtcct gcaagtcttc tggctacacc tttactagct actggataca ctgggtaaaa 540
gagaggcctg gacagggtct ggaatggatt ggatacattt atcctaccac tggttatact 600
gagtccaatc agaagttcaa ggacaaggcc acattgactg cagacaaatc ctccagcaca 660
gcctacatgc aactgagcag cctgacatct gaggactctg cagtctatta ctgtttccta 720
ctacggccct ggtacttcga tgtctggggc gcagggacca cggtcaccgt ctcctcgagc 780


<210> 265
<211> 240
<212> PRT
<213> Artificial Sequence

<220> 
<223> 11H09 anti-RON scFv mature protein without the
      signal peptide but with junction amino acids SSS
      at carboxy-terminus

<400> 265
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser
            20                  25                  30          
Leu Ser Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile
        35                  40                  45              
Tyr Ser Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly
    50                  55                  60                  
Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65                  70                  75                  80  
Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln
        115                 120                 125             
Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala Ser Val Lys Met Ser Cys
    130                 135                 140                 
Lys Ser Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Ile His Trp Val Lys
145                 150                 155                 160 
Glu Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Thr
                165                 170                 175     
Thr Gly Tyr Thr Glu Ser Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu
            180                 185                 190         
Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu
        195                 200                 205             
Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Phe Leu Leu Arg Pro Trp
    210                 215                 220                 
Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ser
225                 230                 235                 240 


<210> 266
<211> 2103
<212> DNA
<213> Artificial Sequence

<220> 
<223> 11H09 anti-RON single chain polypeptide (11H09
      scFv-CH1-CH2-CH3-Ck with signal peptide)

<400> 266
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt 60
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt 120
ctcacttgtc gggcaagtca ggacattggt agtagcttaa gctggcttca gcaggaacca 180
gatggtacta ttaaacgcct gatctactcc acatccagtt tagattctgg tgtccccaaa 240
aggttcagtg gcagtaggtc ggggtcagat tattctctca ccatcagcag ccttgagtct 300
gaagattttg tagactatta ctgtctacaa tatgctagtt ctccgtggac gttcggtgga 360
ggcaccaagc tggaaatcaa aggtggcggt ggctctggcg gaggtggatc cggtggcggc 420
ggctctcagg tccagcttca gcagtctggg gctgaactgg caaaacctgg ggcctcagtg 480
aagatgtcct gcaagtcttc tggctacacc tttactagct actggataca ctgggtaaaa 540
gagaggcctg gacagggtct ggaatggatt ggatacattt atcctaccac tggttatact 600
gagtccaatc agaagttcaa ggacaaggcc acattgactg cagacaaatc ctccagcaca 660
gcctacatgc aactgagcag cctgacatct gaggactctg cagtctatta ctgtttccta 720
ctacggccct ggtacttcga tgtctggggc gcagggacca cggtcaccgt ctcctcgagc 780
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 840
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgagccggt gacggtgtcg 900
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 960
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 1020
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttcgtacg 1080
gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccatccgg agcacctgaa 1140
ctcctgggtg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc 1200
tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc 1260
aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag 1320
gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg 1380
ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag 1440
aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca 1500
tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat 1560
ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc 1620
acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac 1680
aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac 1740
aaccactaca cgcagaagag cctctccctg tctccgggta aatctagaac tgtggctgca 1800
ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac tgcctctgtt 1860
gtgtgcctgc tgaataactt ctatcccaga gaggccaaag tacagtggaa ggtggataac 1920
gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa ggacagcacc 1980
tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca caaagtctac 2040
gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga 2100
gag                                                               2103

<210> 267
<211> 681
<212> PRT
<213> Artificial Sequence

<220> 
<223> 11H09 anti-RON single chain polypeptide (11H09
      scFv-CH1-CH2-CH3-Ck mature protein without the
      signal peptide)

<400> 267
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser
            20                  25                  30          
Leu Ser Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile
        35                  40                  45              
Tyr Ser Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly
    50                  55                  60                  
Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65                  70                  75                  80  
Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln
        115                 120                 125             
Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala Ser Val Lys Met Ser Cys
    130                 135                 140                 
Lys Ser Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Ile His Trp Val Lys
145                 150                 155                 160 
Glu Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Thr
                165                 170                 175     
Thr Gly Tyr Thr Glu Ser Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu
            180                 185                 190         
Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu
        195                 200                 205             
Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Phe Leu Leu Arg Pro Trp
    210                 215                 220                 
Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ser
225                 230                 235                 240 
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
                245                 250                 255     
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            260                 265                 270         
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        275                 280                 285             
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    290                 295                 300                 
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
305                 310                 315                 320 
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                325                 330                 335     
Lys Val Arg Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro
            340                 345                 350         
Pro Cys Pro Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
        355                 360                 365             
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
    370                 375                 380                 
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val
385                 390                 395                 400 
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
                405                 410                 415     
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
            420                 425                 430         
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
        435                 440                 445             
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
    450                 455                 460                 
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
465                 470                 475                 480 
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
                485                 490                 495     
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
            500                 505                 510         
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
        515                 520                 525             
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
    530                 535                 540                 
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
545                 550                 555                 560 
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg
                565                 570                 575     
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
            580                 585                 590         
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
        595                 600                 605             
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
    610                 615                 620                 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
625                 630                 635                 640 
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
                645                 650                 655     
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
            660                 665                 670         
Val Thr Lys Ser Phe Asn Arg Gly Glu
        675                 680     


<210> 268
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 268
Gly Lys Asn Asn Arg Pro Ser
 1               5          


<210> 269
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 269
Asn Ser Arg Asp Ser Ser Gly Asn Leu Val Phe
 1               5                  10      


<210> 270
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 270
Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala Ser
 1               5                  10      


<210> 271
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 271
Gln Asp Arg Lys Arg Pro Ser
 1               5          


<210> 272
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 272
Gln Ala Trp Asp Ser Asn Thr Val Val
 1               5                  


<210> 273
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 273
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asp Tyr Val His
 1               5                  10              


<210> 274
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 274
Arg Asn Asn Lys Arg Pro Ser
 1               5          


<210> 275
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 275
Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val
 1               5                  10      


<210> 276
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 276
Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala Ser
 1               5                  10      


<210> 277
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 277
Glu Asp Asn Lys Arg Pro Ser
 1               5          


<210> 278
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 278
Gln Thr Trp Ala Ser Gly Thr Val Leu
 1               5                  


<210> 279
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 279
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn
 1               5                  10              


<210> 280
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 280
Ala Asn Asn Gln Arg Pro Ser
 1               5          


<210> 281
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 281
Ala Val Trp Asp Asp Ser Leu Asn Ala Trp Val
 1               5                  10      


<210> 282
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 282
Ser Gly Asp Lys Leu Glu Asn Lys Tyr Thr Ser
 1               5                  10      


<210> 283
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 283
Glu Asp Ile Glu Arg Pro Ser
 1               5          


<210> 284
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 284
Gln Ala Trp Asp Ser Asn Ile Ala Val Val
 1               5                  10  


<210> 285
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 285
Ser Gly Gly Asn Ser Asn Ile Gly Ser His Tyr Val Tyr
 1               5                  10              


<210> 286
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 286
Arg Asp Asn Gln Arg Pro Ser
 1               5          


<210> 287
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 287
Ala Ala Trp Asp Asp Ser Leu Gly Gly Pro Val
 1               5                  10      


<210> 288
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 288
Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn Ala Val Asn
 1               5                  10              


<210> 289
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 289
Asn Asn Asn Gln Arg Pro Ser
 1               5          


<210> 290
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 290
Gly Gly Asn Asn Ile Gly Asp Lys Ser Val His
 1               5                  10      


<210> 291
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 291
Glu Asp Lys Asn Arg Pro Ala
 1               5          


<210> 292
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 292
Gln Val Trp Asp Ser Ser Thr Asp His His Val
 1               5                  10      


<210> 293
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 293
Gly Gly Asn Asn Ile Gly Thr Thr Ser Val Gln
 1               5                  10      


<210> 294
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 294
Tyr Gly Ser Asp Arg Pro Ser
 1               5          


<210> 295
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 295
Gln Thr Trp Val Lys Gly Ala Gly Ile
 1               5                  


<210> 296
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 296
Arg Ala Ser Gln Ser Ile Arg Asn Tyr Leu Asn
 1               5                  10      


<210> 297
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 297
Ala Ala Ser Ser Leu Gln Ser
 1               5          


<210> 298
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 298
Gln Gln Ser Tyr Val Thr Pro Leu Thr
 1               5                  


<210> 299
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 299
Arg Ala Ser Gln Ser Val Asn Ser Leu Asn
 1               5                  10  


<210> 300
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 300
Gly Ile Ser Ser Leu Arg Arg
 1               5          


<210> 301
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 301
Gln Gln Ser His Ser Val Pro Leu Thr
 1               5                  


<210> 302
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 302
Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly
 1               5                  10      


<210> 303
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 303
Ala Ala Ser Ser Leu Gln Ser
 1               5          


<210> 304
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 304
Leu Gln His Asn Ser Tyr Pro Pro Thr
 1               5                  


<210> 305
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 305
Arg Ala Ser Gln Ser Val Ser Ser Asp Leu Ala
 1               5                  10      


<210> 306
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 306
Asp Ala Phe Lys Arg Ala Thr
 1               5          


<210> 307
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 307
Gln Gln Arg Ser Asn Trp Pro Leu Thr
 1               5                  


<210> 308
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 308
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala
 1               5                  10      


<210> 309
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 309
Asp Ala Ser Asn Arg Ala Thr
 1               5          


<210> 310
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 310
Gln Gln Arg Ser Asn Trp Pro Leu Thr
 1               5                  


<210> 311
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 311
Arg Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Tyr Asn Tyr Leu Asp
 1               5                  10                  15      


<210> 312
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 312
Leu Gly Ser Asn Arg Ala Ser
 1               5          


<210> 313
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 313
Met Gln Ala Leu Gln Ser Pro Leu Thr
 1               5                  


<210> 314
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 314
Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala
 1               5                  10          


<210> 315
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 315
Gly Ala Ser Ser Arg Ala Thr
 1               5          


<210> 316
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 316
Gln Gln Arg Ser Ile
 1               5  


<210> 317
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 317
Arg Thr Ser Gln Tyr Ile Arg Thr Asn Leu Ala
 1               5                  10      


<210> 318
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 318
Asp Gly Ser Asn Arg Ala Thr
 1               5          


<210> 319
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 319
Gln Gln Arg Ser Asn Trp Pro Leu Thr
 1               5                  


<210> 320
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 320
Arg Thr Ser Gln Gln Ile Met Thr Tyr Leu Asn
 1               5                  10      


<210> 321
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 321
Val Ala Ser Arg Leu Gln Gly
 1               5          


<210> 322
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 322
Gln Gln Ser Phe Trp Thr Pro Leu Thr
 1               5                  


<210> 323

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 323
 000

<210> 324

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 324
 000

<210> 325

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 325
 000

<210> 326

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 326
 000

<210> 327

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 327
 000

<210> 328

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 328
 000

<210> 329

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 329
 000

<210> 330

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 330
 000

<210> 331

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 331
 000

<210> 332

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 332
 000

<210> 333
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 333
Gln Ala Ser Gln Asp Ile Asp Asn Tyr Leu Asn
 1               5                  10      


<210> 334
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 334
Asp Ala Tyr Asn Leu Lys Ala
 1               5          


<210> 335
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 335
Gln Val Phe Asp Asp Leu Ser Val Thr
 1               5                  


<210> 336
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 336
Arg Ala Ser Gln Gly Ile Lys Asn Asp Leu Gly
 1               5                  10      


<210> 337
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 337
Ala Ala Ser Ser Leu Gln Ser
 1               5          


<210> 338
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 338
Gln Gln Ser Asn Ser Phe Pro Leu Thr
 1               5                  


<210> 339
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 339
Gln Ala Ser His Asp Ile Asn Asn Tyr Leu Asn
 1               5                  10      


<210> 340
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 340
Asp Ala Ser Asn Leu Gln Ser
 1               5          


<210> 341
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 341
Gln Gln Tyr Asp Thr Leu Pro Val Thr
 1               5                  


<210> 342
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 342
Ala Gly Ser Ser Ser Asn Ile Gly Ser Asn Ser Val Tyr
 1               5                  10              


<210> 343
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 343
Ser Asn Asn Lys Arg Pro Ser
 1               5          


<210> 344
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 344
Ala Ala Trp Asp Asp Ser Leu Arg Ser Val Val
 1               5                  10      


<210> 345
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 345
Ser Gly Ser Ser Ser Thr Ile Gly Ser Asn Phe Val Asn
 1               5                  10              


<210> 346
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 346
Thr Asn Asn Gln Arg Pro Ser
 1               5          


<210> 347
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 347
Ala Thr Trp Asp Asp Asn Leu Leu Gly Pro Val
 1               5                  10      


<210> 348
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 348
Arg Ala Ser Glu Gly Ile Ser Ser Arg Leu Ala
 1               5                  10      


<210> 349
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 349
Ala Thr Ser Ser Leu Gln Ser
 1               5          


<210> 350
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 350
Leu Gln Ala Asn Thr Leu Pro Leu Thr
 1               5                  


<210> 351
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 351
Arg Ala Ser Leu Gly Val Ser Asn Tyr Leu Ala
 1               5                  10      


<210> 352
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 352
Ala Ala Ser Ile Leu Gln Thr
 1               5          


<210> 353
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 353
Gln His Tyr Gln Gly Tyr Pro Tyr Thr
 1               5                  


<210> 354
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 354
Arg Ala Ser Gln Ser Ile Asp Thr Tyr Leu Asn
 1               5                  10      


<210> 355
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 355
Ala Ala Ser Lys Leu Glu Asp
 1               5          


<210> 356
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 356
Gln Gln Ser Tyr Ser Ser Pro Gly Ile Thr
 1               5                  10  


<210> 357
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 357
Gln Ala Ser Gln Asp Ile Ser Asp Tyr Leu Asn
 1               5                  10      


<210> 358
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 358
Asp Ala Ser Asn Leu Glu Thr
 1               5          


<210> 359
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 359
Gln Gln Asn Asp Asn Leu Pro Phe Thr
 1               5                  


<210> 360
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 360
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10      


<210> 361
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 361
Ala Ala Ser Ser Leu Gln Ser
 1               5          


<210> 362
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 362
Gln Gln Ser Tyr Ser Thr Pro Tyr Thr
 1               5                  


<210> 363
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 363
Arg Ala Gly Gln Ala Ile Arg Asn Asn Leu Gly
 1               5                  10      


<210> 364
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 364
Ala Ala Ser Ser Leu Gln Ser
 1               5          


<210> 365
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 365
Leu Gln His Asn Ser Phe Pro Tyr Thr
 1               5                  


<210> 366
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 366
Gln Ala Ser Gln Asp Ile Ile Asn Tyr Leu Asn
 1               5                  10      


<210> 367
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 367
Asp Ala Ser Asn Leu Glu Thr
 1               5          


<210> 368
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 368
Gln Gln Tyr Asp Asn Leu Pro Tyr Thr
 1               5                  


<210> 369
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 369
Arg Ala Thr Gln Ser Val Arg His Asn Tyr Leu Ala
 1               5                  10          


<210> 370
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 370
Gly Ala Phe Phe Arg Ala Thr
 1               5          


<210> 371
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 371
Gln Gln Tyr Gly Ser Ser Pro Val Thr
 1               5                  


<210> 372
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 372
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
 1               5                  10      


<210> 373
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 373
Ala Ala Ser Ser Leu Gln Ser
 1               5          


<210> 374
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 374
Gln Gln Ser Tyr Ser Thr Ser Tyr Thr
 1               5                  


<210> 375
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 375
Arg Ala Ser Gln Ser Val Ser Ser Arg Tyr Leu Ala
 1               5                  10          


<210> 376
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 376
Ala Ala Ser Ser Arg Ala Thr
 1               5          


<210> 377
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 377
Gln Gln Tyr Gly Ser Ser Pro Pro Tyr Thr
 1               5                  10  


<210> 378
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 378
Arg Ala Ser Gln Ser Val Ser Phe Ser Leu Ala
 1               5                  10      


<210> 379
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 379
Asp Thr Ser Asn Arg Val Ala
 1               5          


<210> 380
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 380
Gln His Arg Ser Asn Trp Pro Gly
 1               5              


<210> 381
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 381
Gln Ala Ser Gln Asp Ile Ile Asn Tyr Leu Asn
 1               5                  10      


<210> 382
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 382
Asp Ala Ser Asn Leu Glu Thr
 1               5          


<210> 383
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 383
Gln Gln Tyr Asp Asn Leu Pro Tyr Thr
 1               5                  


<210> 384
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 384
Gln Ala Ser Gln His Ile Ser Lys Tyr Leu Asn
 1               5                  10      


<210> 385
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 385
Asp Ala Ser Asn Leu Glu Thr
 1               5          


<210> 386
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 386
Gln Gln Tyr Asp Asn Leu Pro Leu Thr
 1               5                  


<210> 387
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 387
Arg Ala Ser Gln Ser Ile Gly Ser Tyr Leu Asn
 1               5                  10      


<210> 388
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 388
Ala Ala Thr Ser Leu His Thr
 1               5          


<210> 389
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 389
Gln Gln Tyr Asp Asn Tyr Pro Leu Thr
 1               5                  


<210> 390
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 390
Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly
 1               5                  10      


<210> 391
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 391
Ala Ala Ser Ser Leu Gln Ser
 1               5          


<210> 392
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 392
Leu Gln His Asn Ser Tyr Pro Arg Thr
 1               5                  


<210> 393
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 393
Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala
 1               5                  10      


<210> 394
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 394
Gly Ala Ser Thr Arg Ala Thr
 1               5          


<210> 395
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 395
Gln Gln Tyr Asn Asn Trp Pro Arg Thr
 1               5                  


<210> 396
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 396
Arg Ala Ser Gln Arg Ile Ile Asn Tyr Val Ser
 1               5                  10      


<210> 397
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 397
Gly Ala Ser Thr Leu Gln Thr
 1               5          


<210> 398
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 398
Arg Gln Ser Tyr Ser Ser Pro Leu Thr
 1               5                  


<210> 399
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 399
Arg Ala Ser Gln Thr Ile Thr Thr Ser Leu Asn
 1               5                  10      


<210> 400
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 400
Ala Ala Ser Arg Leu Gln Asn
 1               5          


<210> 401
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 401
Gln Gln Ser Tyr Asn Ile Pro Tyr Thr
 1               5                  


<210> 402
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 402
Arg Ala Ser Gln Ser Ile Gly Ser Tyr Leu Asn
 1               5                  10      


<210> 403
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 403
Asp Ala Ser Asn Leu Gln Ser
 1               5          


<210> 404
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 404
Gln Gln Ser Tyr Arg Leu Phe Pro Thr
 1               5                  


<210> 405
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 405
Gln Ala Ser Gln Gly Ile Tyr Asn Tyr Val Asn
 1               5                  10      


<210> 406
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 406
Asp Ala Ser Asn Leu Glu Thr
 1               5          


<210> 407
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 407
Gln Gln Tyr Asp Asp Val Pro Ile Thr
 1               5                  


<210> 408
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 408
Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala
 1               5                  10      


<210> 409
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 409
Ala Ala Ser Ser Leu Gln Ser
 1               5          


<210> 410
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 410
Gln Gln Ala Asn Ser Phe Pro Ile Thr
 1               5                  


<210> 411
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 411
Arg Ser Ser Gln Ser Ile Ala Lys Tyr Leu Thr
 1               5                  10      


<210> 412
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 412
Ala Ala Ser Glu Leu Gln Ser
 1               5          


<210> 413
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 413
Gln Gln Thr Tyr Ser Phe Pro His Thr
 1               5                  


<210> 414
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 414
Ala Gly Asn Asn Ile Gly Ser Lys Ser Val His
 1               5                  10      


<210> 415
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 415
Asp Asp Ser Asp Arg Pro Pro
 1               5          


<210> 416
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 416
Gln Val Trp Asp Ser Asp Ser Asp His Tyr Val
 1               5                  10      


<210> 417
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 417
Ser Gly Asp Arg Leu Gly Asp Lys Tyr Ala Ser
 1               5                  10      


<210> 418
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 418
Asp Asp Ser Glu Arg Pro Ser
 1               5          


<210> 419
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 419
Gln Val Trp Asp Ser Ser Ile Val
 1               5              


<210> 420
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 420
Thr Gly Ser Thr Ser Asp Val Gly Gly Tyr Thr Tyr Val Ser
 1               5                  10                  


<210> 421
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 421
Asp Val Ser Lys Arg Pro Ser
 1               5          


<210> 422
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 422
Cys Ser Tyr Ala Gly Ser Tyr Ser Tyr Val
 1               5                  10  


<210> 423
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 423
Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala Cys
 1               5                  10      


<210> 424
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 424
Gln Asp Ser Lys Arg Pro Ser
 1               5          


<210> 425
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 425
Gln Ala Trp Asp Ser Ser Thr Tyr Val
 1               5                  


<210> 426
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 426
Thr Gly Thr Ser Ser Asp Val Gly Gly His Asn Tyr Val Ser
 1               5                  10                  


<210> 427
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 427
Asp Val Ser Lys Arg Pro Ser
 1               5          


<210> 428
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 428
Cys Ser Tyr Ala Gly Arg Tyr Thr Tyr Val
 1               5                  10  


<210> 429
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 429
Ser Gly Asp Arg Leu Glu Asp Lys Tyr Thr Ser
 1               5                  10      


<210> 430
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 430
Gln Asp Asn Lys Arg Pro Ser
 1               5          


<210> 431
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 431
Gln Ala Trp Asp Ser Ser Ser Ala Tyr Val
 1               5                  10  


<210> 432
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 432
Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His
 1               5                  10      


<210> 433
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 433
Phe Phe Asp Tyr Asp Arg Pro Ser
 1               5              


<210> 434
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 434
Gln Val Trp Asp Ser Arg Thr Asp Arg Tyr Val
 1               5                  10      


<210> 435
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 435
Ile Tyr Asp Met His
 1               5  


<210> 436
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 436
Trp Ile Ser Pro Ser Gly Gly Arg Thr Leu Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 437
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 437
Thr Trp Asp Tyr Tyr Asp Ser Ser Gly Tyr Phe Asn Asp Ala Phe Asp
 1               5                  10                  15      
Ile
    


<210> 438
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 438
Ala Tyr Asn Met Ala
 1               5  


<210> 439
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 439
Ser Ile Val Ser Ser Gly Gly Thr Thr Thr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 440
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 440
Gly Gly Val Gly Trp Leu Leu Asp Tyr
 1               5                  


<210> 441
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 441
Ala Tyr Gln Met Gly
 1               5  


<210> 442
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 442
Ser Ile Ser Ser Ser Gly Gly Tyr Thr Ser Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 443
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 443
Glu Ser Arg Tyr Tyr Phe Asp Tyr
 1               5              


<210> 444
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 444
Glu Tyr Pro Met Ile
 1               5  


<210> 445
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 445
Gly Ile Gly Ser Ser Gly Gly Ser Thr Thr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 446
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 446
Ala Pro Leu Tyr Ser Ser Thr Ser Tyr Ala Phe Asp Ile
 1               5                  10              


<210> 447
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 447
Phe Tyr Trp Met Ile
 1               5  


<210> 448
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 448
Gly Ile Gly Pro Ser Gly Gly Thr Thr Phe Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 449
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 449
Gly Tyr Gly Met Val
 1               5  


<210> 450
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 450
Ser Ile Ser Pro Ser Gly Gly Glu Thr Leu Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 451
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 451
Gly Gln Met Trp Pro Gly Val Ala Phe Glu Met
 1               5                  10      


<210> 452
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 452
Leu Tyr Phe Met Thr
 1               5  


<210> 453
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 453
Ser Ile Gly Ser Ser Asp Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 454
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 454
Asp Leu Ser Trp Trp Pro Asp Ala Phe Asp Ile
 1               5                  10      


<210> 455
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 455
Pro Tyr Arg Met Glu
 1               5  


<210> 456
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 456
Trp Ile Tyr Ser Ser Gly Gly Ile Thr Asn Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 457

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 457
 000

<210> 458
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 458
Val Tyr Asp Met Val
 1               5  


<210> 459
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 459
Ser Ile Gly Pro Ser Gly Gly Trp Thr Gly Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 460
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 460
Asp Ser Gly Gly Trp Glu Ala Leu Tyr Tyr Tyr Tyr Tyr Met Asp Val
 1               5                  10                  15      


<210> 461
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 461
Val Tyr Phe Met Asp
 1               5  


<210> 462
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 462
Gly Ile Gly Pro Ser Gly Gly Val Thr Ser Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 463
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 463
Gly Gln Leu Ala Gln Gly His Tyr Tyr Met Asp Val
 1               5                  10          


<210> 464
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 464
Lys Tyr Asp Met Leu
 1               5  


<210> 465
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 465
Tyr Ile Tyr Pro Ser Gly Gly Leu Thr Glu Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 466
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 466
Arg Ala Pro Arg Ser Leu Ser Phe Asp Ile
 1               5                  10  


<210> 467
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 467
Arg Tyr Met Met Ala
 1               5  


<210> 468
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 468
Ser Ile Tyr Pro Ser Gly Gly Val Thr Glu Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 469
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 469
Glu Gly Trp Tyr Gly Tyr Pro Thr
 1               5              


<210> 470
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 470
Arg Tyr Met Met Gly
 1               5  


<210> 471
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 471
Val Ile Val Pro Ser Gly Gly Phe Thr Met Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 472
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 472
Ser Ser Arg Leu Trp Ser Gly Tyr Tyr Pro Phe Asp Tyr
 1               5                  10              


<210> 473
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 473
Arg Tyr Ser Met Thr
 1               5  


<210> 474
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 474
Ser Ile Tyr Ser Ser Gly Gly Glu Thr Gly Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 475
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 475
Glu Arg Tyr Asn Ser Phe Thr Ser
 1               5              


<210> 476
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 476
Ser Tyr Val Met Val
 1               5  


<210> 477
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 477
Val Ile Ser Pro Ser Gly Gly Val Thr Phe Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 478
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 478
Asp Arg Arg Ser Asn Ser Leu Phe Asp Pro
 1               5                  10  


<210> 479
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 479
Thr Tyr Gly Met Val
 1               5  


<210> 480
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 480
Tyr Ile Trp Pro Ser Gly Gly Leu Thr Trp Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 481
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 481
Ser Gly Tyr Ser Tyr Gly Arg Phe Asp Tyr
 1               5                  10  


<210> 482
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 482
Tyr Tyr Asp Met Gly
 1               5  


<210> 483
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 483
Trp Ile Ser Pro Ser Gly Gly Ser Thr Leu Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 484
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 484
Ser Gly Leu Tyr Gly Ser Gly Ser Tyr Ala Ala Phe Asp Val
 1               5                  10                  


<210> 485
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 485
Tyr Tyr His Met Val
 1               5  


<210> 486
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 486
Tyr Ile Ser Pro Ser Gly Gly Asp Thr His Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 487
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 487
Gly Arg Tyr Tyr Gly Met Asp Val
 1               5              


<210> 488
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 488
Gly Tyr Ile Met Met
 1               5  


<210> 489
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 489
Gly Ile Tyr Pro Ser Gly Gly Gly Thr Asp Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 490
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 490
Glu Arg Pro Gly Tyr Tyr Asp Ser Thr Asp Asp Asp Tyr Tyr Tyr Tyr
 1               5                  10                  15      
Pro Met Asp Val
            20  


<210> 491
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 491
Val Tyr Trp Met Glu
 1               5  


<210> 492
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 492
Ser Ile Ser Ser Ser Gly Gly Leu Thr Ser Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 493
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 493
Asp Leu Val Ser Asn Trp Pro Trp Gly Gly Tyr
 1               5                  10      


<210> 494
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 494
His Tyr Lys Met Gly
 1               5  


<210> 495
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 495
Ser Ile Ser Ser Ser Gly Gly Asp Thr Ala Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 496
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 496
Asp Arg Ala Pro Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Ser Asp Tyr
 1               5                  10                  15      


<210> 497
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 497
His Tyr Ala Met Tyr
 1               5  


<210> 498
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 498
Ser Ile Ser Pro Ser Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 499
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 499
Glu Ser Gly Thr Thr Asn Ala Phe Asp Ile
 1               5                  10  


<210> 500
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 500
Asn Tyr His Met Glu
 1               5  


<210> 501
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 501
Tyr Ile Ser Pro Ser Gly Gly Ser Thr His Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 502
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 502
Asp Gly Trp Thr Val Pro Arg Asp
 1               5              


<210> 503
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 503
Arg Tyr Trp Met Ala
 1               5  


<210> 504
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 504
Ser Ile Val Ser Ser Gly Gly Met Thr Asp Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 505
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 505
His Arg Gly Asp Ser Gly Leu Asp Tyr
 1               5                  


<210> 506
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 506
His Tyr Pro Met Leu
 1               5  


<210> 507
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 507
Gly Ile Ser Ser Ser Gly Gly Trp Thr Asp Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 508
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 508
Asp Arg Ala Leu Gly Met Asp Val
 1               5              


<210> 509
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 509
Leu Tyr Ser Met Val
 1               5  


<210> 510
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 510
Arg Ile Arg Pro Ser Gly Gly Gln Thr Met Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 511
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 511
Gly Tyr Ala Phe Asp Ile
 1               5      


<210> 512
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 512
Phe Tyr Asp Met Leu
 1               5  


<210> 513
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 513
Ser Ile Trp Ser Ser Gly Gly Gln Thr Gly Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 514
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 514
Glu Lys Ala Ser Asp Leu Ser Gly Ser Tyr Ser Glu Ala Leu Asp Tyr
 1               5                  10                  15      


<210> 515
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 515
Asn Tyr His Met Asn
 1               5  


<210> 516
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 516
Tyr Ile Tyr Pro Ser Gly Gly Val Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 517
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 517
Gly Ile Ala Ala Ala Gly Asn Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val
 1               5                  10                  15      


<210> 518
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 518
Lys Tyr Gly Met Val
 1               5  


<210> 519
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 519
Ser Ile Ser Ser Ser Gly Gly Asn Thr Ala Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 520
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 520
Gly Glu Leu Glu Arg Arg Arg Arg Asn Tyr Tyr Gly Met Asp Val
 1               5                  10                  15  


<210> 521
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 521
Asn Tyr Ala Met Thr
 1               5  


<210> 522
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 522
Ser Ile Tyr Ser Ser Gly Gly Asp Thr Ala Tyr Ala Asp Tyr Val Lys
 1               5                  10                  15      
Gly
    


<210> 523
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 523
Glu Tyr Tyr Thr Gly Trp Asn Phe Asp Tyr
 1               5                  10  


<210> 524
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 524
Gln Tyr Asp Met Val
 1               5  


<210> 525
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 525
Tyr Ile Tyr Ser Ser Gly Gly His Thr Leu Tyr Val Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 526
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 526
Ile Arg Ser Ser Gly Tyr Tyr His Glu Val Leu Asp Tyr
 1               5                  10              


<210> 527
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 527
Thr Tyr Met Met Tyr
 1               5  


<210> 528
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 528
Val Ile Gly Pro Ser Gly Gly Ala Thr Gly Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 529
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 529
Ile Arg Lys Ala Phe Gly Tyr Gly Ser Gly Ser Leu Asp Tyr
 1               5                  10                  


<210> 530
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 530
Tyr Tyr Asp Met Gln
 1               5  


<210> 531
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 531
Tyr Ile Gly Pro Ser Gly Gly Asp Thr Asp Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 532
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 532
Ser Ser Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr His Glu Ala Phe Asp
 1               5                  10                  15      
Ile
    


<210> 533
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 533
Tyr Tyr Met Met Arg
 1               5  


<210> 534
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 534
Tyr Ile Gly Pro Ser Gly Gly Ala Thr Thr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 535
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 535
Gly Arg Ser Val Lys Tyr Tyr Tyr Asp Ser Ser Gly Tyr Leu Leu Phe
 1               5                  10                  15      
Asp Tyr
        


<210> 536
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 536
His Tyr Ser Met Tyr
 1               5  


<210> 537
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 537
Gly Ile Tyr Ser Ser Gly Gly Pro Thr Ile Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 538
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 538
Leu Gln Ile Glu Met Ala Thr Ile Gly His Phe Asp Tyr
 1               5                  10              


<210> 539
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 539
Gln Tyr Asp Met Val
 1               5  


<210> 540
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 540
Tyr Ile Tyr Ser Ser Gly Gly His Thr Leu Tyr Val Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 541
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 541
Ile Arg Ser Ser Gly Tyr Tyr His Glu Val Leu Asp Tyr
 1               5                  10              


<210> 542
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 542
His Tyr Trp Met Met
 1               5  


<210> 543
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 543
Ser Ile Val Pro Ser Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 544
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 544
Asp Pro Val Met Thr Pro Val Asp Tyr
 1               5                  


<210> 545
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 545
Pro Tyr Phe Met Asn
 1               5  


<210> 546
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 546
Ser Ile Tyr Pro Ser Gly Gly Ile Thr Lys Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 547
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 547
Glu Thr Tyr Tyr Tyr Gly Ser Gly Ser Tyr Ala Phe Asp Ile
 1               5                  10                  


<210> 548
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 548
Gln Tyr Tyr Met Tyr
 1               5  


<210> 549
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 549
Arg Ile Ser Pro Ser Gly Gly Met Thr Ser Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 550
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 550
His Lys Tyr Gly Gly Pro Asp Phe
 1               5              


<210> 551
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 551
Arg Tyr Gln Met Asn
 1               5  


<210> 552
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 552
Ser Ile Arg Ser Ser Gly Gly Val Thr Lys Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 553
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 553
Gly Arg Gly Leu Ser Ser
 1               5      


<210> 554
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 554
Leu Tyr Thr Met Ala
 1               5  


<210> 555
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 555
Tyr Ile Ser Pro Ser Gly Gly Phe Thr Gly Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 556
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 556
Trp Gly Asp Pro
 1              


<210> 557
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 557
Asp Tyr Phe Met Gly
 1               5  


<210> 558
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 558
Arg Ile Ser Ser Ser Gly Gly His Thr Met Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 559
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 559
Glu Glu Asp Tyr Tyr Asp Ser Ser Gly Tyr Tyr Pro Pro Ala Phe Asp
 1               5                  10                  15      
Ile
    


<210> 560
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 560
Ile Tyr Trp Met Tyr
 1               5  


<210> 561
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 561
Gly Ile Gly Pro Ser Gly Gly Tyr Thr Ser Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 562
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 562
Gly Asn Gly Gly Phe Asp Ser
 1               5          


<210> 563
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 563
Pro Tyr His Met Ser
 1               5  


<210> 564
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 564
Ser Ile Tyr Pro Ser Gly Gly Phe Thr Ala Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 565
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 565
Glu Ser Ala Tyr Tyr Tyr Asp Ser Ser Pro Pro Ala Phe Asp Ile
 1               5                  10                  15  


<210> 566
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 566
Thr Tyr Ala Met Tyr
 1               5  


<210> 567
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 567
Ser Ile Tyr Ser Ser Gly Gly Ala Thr Trp Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 568
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 568
Ser Thr Phe Asp Tyr Phe Asp Tyr
 1               5              


<210> 569
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 569
Lys Tyr Arg Met Met
 1               5  


<210> 570
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 570
Tyr Ile Ser Ser Ser Gly Gly Ala Thr Ile Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 571
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 571
His Gly Pro Gln Ile Ala Ala Trp Tyr Phe Asp Leu
 1               5                  10          


<210> 572
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 572
Pro Tyr Ser Met Asp
 1               5  


<210> 573
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 573
Gly Ile Ser Ser Ser Gly Gly Arg Thr Val Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 574
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 574
Gly Pro Tyr Tyr Asp Phe Trp Ser Gly Tyr Tyr Ile Asp Arg Gly Pro
 1               5                  10                  15      
Leu Asp Tyr
            


<210> 575
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 575
Trp Tyr Met Met Ala
 1               5  


<210> 576
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 576
Trp Ile Ser Ser Ser Gly Gly Phe Thr Pro Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 577
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 577
Gly Gln Gln Trp Pro Gly Val Ala Phe Asp Ile
 1               5                  10      


<210> 578
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 578
Phe Tyr Pro Met Met
 1               5  


<210> 579
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 579
Tyr Ile Gly Pro Ser Gly Gly Asn Asn Ala Asp Ser Val Lys Gly
 1               5                  10                  15  


<210> 580
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 580
Gly Leu Trp Phe Gly Gly Arg Leu Asp Tyr
 1               5                  10  


<210> 581
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 581
His Tyr Trp Met Lys
 1               5  


<210> 582
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 582
Gly Ile Ser Ser Ser Gly Gly Gln Thr Asp Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 583
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 583
Ser Pro Arg Leu Arg Phe Leu Glu Trp Pro Arg Asn Tyr Tyr Gly Met
 1               5                  10                  15      
Asp Val
        


<210> 584
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 584
Leu Tyr Met Met Val
 1               5  


<210> 585
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 585
Tyr Ile Gly Pro Ser Gly Gly Ala Tyr Ala Asp Ser Val Lys Gly
 1               5                  10                  15  


<210> 586
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 586
Ser Val Arg Gly Leu Thr Phe Asp Tyr
 1               5                  


<210> 587
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 587
Pro Tyr Glu Met Gly
 1               5  


<210> 588
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 588
Arg Ile Ser Pro Ser Gly Gly Met Thr Leu Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 589
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 589
Met Gly Arg Gly Gly Trp Trp Ala Phe Asp Ala Phe Asp Ile
 1               5                  10                  


<210> 590
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 590
Trp Tyr Lys Met Val
 1               5  


<210> 591
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 591
Gly Ile Tyr Pro Ser Gly Gly Thr Thr His Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 592
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 592
Gly Gly Gly Asp Phe Trp Ser Gly Tyr Tyr Pro Phe Asp Tyr
 1               5                  10                  


<210> 593
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining
      Region

<400> 593
Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val
 1               5                  10      


<210> 594
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Heavy Chain Complementarity Determining
      Region

<400> 594
Gly Gly Ser Tyr Phe Asp Leu
 1               5          


<210> 595
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 CH2 with L235A, E318A, K320A and K322A
      substitutions

<400> 595
Ala Pro Glu Leu Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            100                 105                 110 


<210> 596
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 CH2 with L234A, L235A, G237A, E318A,
      K320A and K322A

<400> 596
Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            100                 105                 110 


<210> 597
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-c-Met Light Chain Complementarity Determining

<400> 597
Gln Gly Asp Ser Leu Arg Asn Tyr His Pro Ser
 1               5                  10      


<210> 598
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Junction amino acids

<400> 598
Arg Asp Gln
 1          


<210> 599
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Junction amino acids

<400> 599
Ser Ala Ser Ser
 1              


<210> 600
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Junction amino acids

<400> 600
Ser Ser Ser
 1          


<210> 601
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> NKG2D Linker

<400> 601
Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr
 1               5                  10                  15      
Ser
    


<210> 602
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-RON mAb 4C04 light chain

<400> 602
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly
 1               5                  10                  15      
Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Ala
    50                  55                  60                  
Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Asp Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Asn Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 603
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-RON mAb 4C04 heavy chain

<400> 603
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Asp Tyr Thr Leu Thr Asp Phe
            20                  25                  30          
Tyr Met Asn Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Tyr Pro Gly Thr Asp Lys Thr Arg Tyr Asn Glu Lys Phe
    50                  55                  60                  
Arg Asp Lys Ala Ile Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Ser Ala Tyr Tyr Gly Asn Tyr Val Ala Met Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Ser Val Thr Val Ser Ser
        115                 120     


<210> 604
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-RON mAb 4C04 light chain CDR1

<400> 604
Gln Thr Ile Gly Thr Trp
 1               5      


<210> 605
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-RON mAb 4C04 light chain CDR2

<400> 605
Ala Ala Thr
 1          


<210> 606
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-RON mAb 4C04 light chain CDR3

<400> 606
Gln Gln Leu Tyr Asn Thr Pro Trp Thr
 1               5                  


<210> 607
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-RON mAb 4C04 heavy chain CDR1

<400> 607
Asp Tyr Thr Leu Thr Asp Phe Tyr
 1               5              


<210> 608
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-RON mAb 4C04 heavy chain CDR2

<400> 608
Ile Tyr Pro Gly Thr Asp Lys Thr
 1               5              


<210> 609
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-RON mAb 4C04 heavy chain CDR3

<400> 609
Ala Arg Ser Ala Tyr Tyr Gly Asn Tyr Val Ala Met Asp Tyr
 1               5                  10                  


<210> 610
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-RON mAb 11H09 light chain

<400> 610
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser
            20                  25                  30          
Leu Ser Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile
        35                  40                  45              
Tyr Ser Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly
    50                  55                  60                  
Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65                  70                  75                  80  
Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 611
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-RON mAb 11H09 heavy chain

<400> 611
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ser Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Ile His Trp Val Lys Glu Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Tyr Pro Thr Thr Gly Tyr Thr Glu Ser Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Phe Leu Leu Arg Pro Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr
            100                 105                 110         
Val Thr Val Ser Ser
        115         


<210> 612
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-RON mAb 11H09 light chain CDR1

<400> 612
Gln Asp Ile Gly Ser Ser
 1               5      


<210> 613
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-RON mAb 11H09 light chain CDR2

<400> 613
Ser Thr Ser
 1          


<210> 614
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-RON mAb 11H09 light chain CDR3

<400> 614
Leu Gln Tyr Ala Ser Ser Pro Trp Thr
 1               5                  


<210> 615
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-RON mAb 11H09 heavy chain CDR1

<400> 615
Gly Tyr Thr Phe Thr Ser Tyr Trp
 1               5              


<210> 616
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-RON mAb 11H09 heavy chain CDR2

<400> 616
Ile Tyr Pro Thr Thr Gly Tyr Thr
 1               5              


<210> 617
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-RON mAb 11H09 heavy chain CDR3

<400> 617
Phe Leu Leu Arg Pro Trp Tyr Phe Asp Val
 1               5                  10  

<210> 618
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 618
Asn Ser
 1

<210> 619
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 619
Ser Cys Pro Pro Cys Pro
 1               5

<210> 620
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 620
Gly Gly Gly Gly Ser Gly Asn Ser
 1               5

<210> 621
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 621
Gly Cys Pro Pro Cys Pro Asn Ser
 1               5

<210> 622
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 622
Gly Ser Pro Pro Ser Pro Asn Ser
 1               5

<210> 623
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 623
Gly Ser Pro Pro Ser Pro Asn Ser
 1               5

<210> 624
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 624
Gly Cys Pro Pro Cys Pro Asn Ser
 1               5

<210> 625
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 625
Gly Cys Pro Pro Cys Pro Asn Ser
 1               5

<210> 626
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 626
Gly Cys Pro Pro Cys Pro Gly Asn Ser
 1               5

<210> 627
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 627
Gly Cys Pro Pro Cys Pro Ala Asn Ser
 1               5

<210> 628
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 628
Gly Cys Pro Pro Cys Pro Ala Asn Ser
 1               5

<210> 629
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 629
Glu Glu Glu Glu Asp Glu Gly Asn Ser
 1               5

<210> 630
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 630
Asn Tyr Gly Gly Gly Gly Ser Gly Asn Ser
 1               5                  10

<210> 631
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 631
Val Ser Glu Arg Pro Phe Pro Pro Asn Ser
 1               5                  10

<210> 632
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 632
Glu Pro Lys Ser Cys Asp Lys Thr Cys Cys Pro
 1               5                  10

<210> 633
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 633
Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ser
 1               5                  10

<210> 634
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 634
Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Asn Ser
 1               5                  10

<210> 635
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 635
Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser
 1               5                  10

<210> 636
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 636
Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser
 1               5                  10

<210> 637
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 637
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Cys Pro
 1               5                  10

<210> 638
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 638
Glu Pro Lys Ser Cys Asp Lys Thr Cys Pro Pro Cys Pro
 1               5                  10

<210> 639
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 639
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser
 1               5                  10

<210> 640
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 640
Gly Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Asn Ser
 1               5                  10

<210> 641
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 641
Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Gly Asn Ser
 1               5                  10

<210> 642
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 642
Gly Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Asn Ser
 1               5                  10

<210> 643
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 643
Gly Gly Gly Ala Ser Cys Pro Pro Cys Pro Gly Asn Ser
 1               5                  10

<210> 644
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 644
Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser
 1               5                  10

<210> 645
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 645
Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser
 1               5                  10

<210> 646
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 646
Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser
 1               5                  10                  15

<210> 647
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 647
Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser
 1               5                  10                  15

<210> 648
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 648
Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser
 1               5                  10                  15

<210> 649
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 649
Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Asn Ser
 1               5                  10                  15

<210> 650
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 650
Leu Asp Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Asn Ser
 1               5                  10                  15

<210> 651
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 651
Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Asn Ser
 1               5                  10                  15

<210> 652
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 652
Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser
 1               5                  10                  15

<210> 653
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 653
Asp Thr Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Ser Asn Ser
 1               5                  10                  15

<210> 654
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 654
Leu Pro Pro Glu Thr Gln Glu Ser Gln Glu Val Thr Leu Asn Ser
 1               5                  10                  15

<210> 655
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 655
Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Asn Ser
 1               5                  10                  15

<210> 656
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 656
Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser
 1               5                  10                  15

<210> 657
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 657
Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser
 1               5                  10                  15

<210> 658
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 658
Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser
 1               5                  10                  15

<210> 659
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 659
Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser
 1               5                  10                  15

<210> 660
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 660
Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser
 1               5                  10                  15

<210> 661
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 661
Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser
 1               5                  10                  15

<210> 662
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 662
Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met Pro Asn Ser
 1               5                  10                  15

<210> 663
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 663
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15

<210> 664
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 664
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 665
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 665
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser
 1               5                  10                  15

<210> 666
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 666
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser
 1               5                  10                  15

<210> 667
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 667
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 668
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 668
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser
 1               5                  10                  15

<210> 669
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 669
Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro
 1               5                  10                  15

<210> 670
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 670
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Ser
 1               5                  10                  15

<210> 671
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 671
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser
 1               5                  10                  15

<210> 672
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 672
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser
 1               5                  10                  15

<210> 673
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 673
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro
 1               5                  10                  15

<210> 674
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 674
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro
 1               5                  10                  15

<210> 675
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 675
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro
 1               5                  10                  15

<210> 676
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 676
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro
 1               5                  10                  15

<210> 677
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 677
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro
 1               5                  10                  15

<210> 678
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 678
Gly Gly Gly Gly Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 679
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 679
Glu Pro Lys Ser Cys Gly Gly Gly Gly Gly Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 680
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 680
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Gly Gly Cys Pro
 1               5                  10                  15

<210> 681
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 681
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Gly
 1               5                  10                  15

<210> 682
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 682
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Pro
 1               5                  10                  15

<210> 683
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 683
Glu Pro Lys Ser Cys Asp Lys Cys His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 684
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 684
Glu Pro Lys Ser Cys Asp Lys Thr Cys Cys Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 685
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 685
Glu Pro Lys Ser Cys Pro Pro Pro Pro Pro Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 686
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 686
Pro Pro Pro Pro Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 687
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 687
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Trp Trp Cys Pro
 1               5                  10                  15

<210> 688
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 688
Glu Pro Lys Ser Cys Asp Trp Trp His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 689
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 689
Glu Pro Lys Cys Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 690
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 690
Glu Pro Lys Ser Asp Cys Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 691
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 691
Glu Pro Lys Ser Asp Cys Trp Trp His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 692
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 692
Glu Pro Lys Ser Cys Asp Phe Phe His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 693
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 693
Glu Pro Lys Ser Cys Asp Trp Trp Trp Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 694
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 694
Glu Pro Lys Ser Cys Trp Trp Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 695
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 695
Glu Pro Trp Trp Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 696
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 696
Ser Gln Pro Glu Ile Val Pro Ile Ser Cys Pro Pro Cys Pro Asn Ser
 1               5                  10                  15

<210> 697
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 697
Thr Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys
 1               5                  10                  15
Pro


<210> 698
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 698
Glu Pro Lys Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn
 1               5                  10                  15
Ser


<210> 699
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 699
Glu Pro Lys Ser Thr Asp Lys Thr His Thr Ser Pro Pro Ser Pro Asn
 1               5                  10                  15
Ser


<210> 700
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 700
Glu Pro Lys Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn
 1               5                  10                  15
Ser


<210> 701
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 701
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn
 1               5                  10                  15
Ser


<210> 702
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 702
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Gly Gly Gly Pro
 1               5                  10                  15
Cys Pro


<210> 703
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 703
Glu Pro Lys Ser Cys Asp Gly Gly Gly Lys Thr His Thr Cys Pro Pro
 1               5                  10                  15
Cys Pro


<210> 704
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 704
Glu Pro Lys Ser Cys Asp Pro Pro Pro Lys Thr His Thr Cys Pro Pro
 1               5                  10                  15
Cys Pro


<210> 705
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 705
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Pro Pro Pro
 1               5                  10                  15
Cys Pro


<210> 706
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 706
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
 1               5                  10                  15
Asn Ser


<210> 707
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 707
Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
 1               5                  10                  15
Ser Asn Ser


<210> 708
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 708
Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Ser Pro Pro Cys
 1               5                  10                  15
Pro Asn Ser


<210> 709
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 709
Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro Cys
 1               5                  10                  15
Pro Asn Ser


<210> 710
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 710
Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala
 1               5                  10                  15
Arg His Ser Pro
            20

<210> 711
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 711
Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro
 1               5                  10                  15
Cys Pro Asn Ser
            20

<210> 712
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 712
Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Cys Pro Pro
 1               5                  10                  15
Cys Pro Asn Ser
            20

<210> 713
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 713
Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Cys Pro Pro
 1               5                  10                  15
Cys Pro Asn Ser
            20

<210> 714
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 714
Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Cys Pro Pro
 1               5                  10                  15
Cys Pro Asn Ser
            20

<210> 715
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 715
Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Cys Pro Pro
 1               5                  10                  15
Cys Pro Asn Ser
            20

<210> 716
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 716
Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr
 1               5                  10                  15
Cys Pro Asn Ser
            20

<210> 717
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 717
Glu Glu Glu Glu Asp Glu Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu
 1               5                  10                  15
Asp Gly Asn Ser
            20

<210> 718
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 718
Leu Asp Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Ser Cys Pro
 1               5                  10                  15
Pro Cys Pro Asn Ser
            20

<210> 719
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 719
Asp Thr Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Ser Cys Pro
 1               5                  10                  15
Pro Cys Pro Asn Ser
            20

<210> 720
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 720
Leu Pro Pro Glu Thr Gln Glu Ser Gln Glu Val Thr Leu Ser Cys Pro
 1               5                  10                  15
Pro Cys Pro Asn Ser
            20

<210> 721
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 721
Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser
 1               5                  10                  15
Asp Cys Pro Asn Ser
            20

<210> 722
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 722
Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg
 1               5                  10                  15
His Cys Pro Asn Ser
            20

<210> 723
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 723
Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg
 1               5                  10                  15
His Ser Pro Asn Ser
            20

<210> 724
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 724
Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
 1               5                  10                  15
Ser Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
            20                  25                  30
Gly Ser Asn Ser
        35

<210> 725
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 725
Arg Thr Arg Tyr Leu Gln Val Ser Gln Gln Leu Gln Gln Thr Asn Arg
 1               5                  10                  15
Val Leu Glu Val Thr Asn Ser Ser Leu Arg Gln Gln Leu Arg Leu Lys
            20                  25                  30
Ile Thr Gln Leu Gly Gln Ser Ala Glu Asp Leu Gln Gly Ser Arg Arg
        35                  40                  45
Glu Leu Ala Gln Ser Gln Glu Ala Leu Gln Val Glu Gln Arg Ala His
    50                  55                  60
Gln Ala Ala Glu Gly Gln Leu Gln Ala Cys Gln Ala Asp Arg Gln Lys
65                  70                  75                  80
Thr Lys Glu Thr Leu Gln Ser Glu Glu Gln Gln Arg Arg Ala Leu Glu
                85                  90                  95
Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr Cys
            100                 105                 110
Gly Ser Ala Asp Thr Cys Cys Pro Asn Ser
        115                 120

<210> 726
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 726
Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser
 1               5                  10

<210> 727
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 727
Asn Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
 1               5                  10                  15
Gly Ser Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
            20                  25                  30
Gly Gly Gly Ser Gly Asn Ser
        35

<210> 728
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 728
Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
 1               5                  10                  15
Ser Gly Asn Ser
            20

<210> 729
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 729
Ser Pro Pro Ser Pro Asn Ser
 1               5

<210> 730
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 730
Glu Pro Thr Ser Thr Asp Lys Thr His Thr Ser Pro Pro Ser Pro Asn
 1               5                  10                  15
Ser


<210> 731
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 731
Glu Pro Thr Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn
 1               5                  10                  15
Ser


<210> 732
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 732
Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Ser Pro Pro Cys
 1               5                  10                  15
Pro Asn Ser


<210> 733
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 733
Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Asn Ser
 1               5                  10

<210> 734
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 734
Arg Thr Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys
 1               5                  10                  15
Ala Arg His Ser Gly His
            20

<210> 735
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 735
Arg Thr Arg Tyr Leu Gln Val Ser Gln Gln Leu Gln Gln Thr Asn Arg
 1               5                  10                  15
Val Leu Glu Val Thr Asn Ser Ser Leu Arg Gln Gln Leu Arg Leu Lys
            20                  25                  30
Ile Thr Gln Leu Gly Gln Ser Ala Glu Asp Leu Gln Gly Ser Arg Arg
        35                  40                  45
Glu Leu Ala Gln Ser Gln Glu Ala Leu Gln Val Glu Gln Arg Ala His
    50                  55                  60
Gln Ala Ala Glu Gly Gln Leu Gln Ala Cys Gln Ala Asp Arg Gln Lys
65                  70                  75                  80
Thr Lys Glu Thr Leu Gln Ser Glu Glu Gln Gln Arg Arg Ala Leu Glu
                85                  90                  95
Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr Cys
            100                 105                 110
Gly Ser Ala Asp Thr Cys
        115

<210> 736
<211> 35
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 736
Arg Thr Gln Ser Glu Glu Gln Gln Arg Arg Ala Leu Glu Gln Lys Leu
 1               5                  10                  15
Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr Cys Gly Ser Ala
            20                  25                  30
Asp Thr Cys
        35

<210> 737
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 737
Arg Thr Glu Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe
 1               5                  10                  15
Phe Thr Cys Gly Ser Ala Asp Thr Cys
            20                  25

<210> 738
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 738
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
            20                  25

<210> 739
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 739
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser
 1               5                  10                  15

<210> 740
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 740
Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 741
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 741
Gly Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro
 1               5                  10                  15
Cys Pro


<210> 742
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 742
Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly
 1               5                  10                  15
His Ser Pro Asn Ser
            20

<210> 743
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 743
Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Lys Ala Arg
 1               5                  10                  15
His Ser Pro Asn Ser
            20

<210> 744
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 744
Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Arg
 1               5                  10                  15
His Ser Pro Asn Ser
            20

<210> 745
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 745
Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Gly
 1               5                  10                  15
His Ser Pro Asn Ser
            20

<210> 746
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 746
Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Met Ala Gly
 1               5                  10                  15
His Ser Pro Asn Ser
            20

<210> 747
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Made in a lab

<400> 747
Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Met Ala Arg
 1               5                  10                  15
His Ser Pro Asn Ser
            20

<210> 748
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge sequence

<400> 748
Pro Pro Pro Pro Pro Cys Pro Pro Cys Pro
 1               5                  10  


<210> 749
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge sequence

<400> 749
Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15      


<210> 750
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge sequence

<400> 750
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Cys
 1               5                  10                  15      
Pro Pro Cys Pro
            20  


<210> 751
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge sequence

<400> 751
Glu Pro Lys Ser Ser Asp Thr Pro Pro Pro Ser Pro Arg Ser Pro Cys
 1               5                  10                  15      
Pro Pro Cys Pro
            20  


<210> 752
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge sequence

<400> 752
Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser
 1               5                  10                  15      
Pro Ser Cys Pro Pro Cys Pro
            20              


<210> 753
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge sequence

<400> 753
Arg Thr Glu Pro Arg Val Pro Ile Thr Gln Asn Pro Cys Pro Pro Leu
 1               5                  10                  15      
Lys Glu Cys Pro Pro Cys Ala
            20              


<210> 754
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge sequence

<400> 754
Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln
 1               5                  10                  15      
Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg
            20                  25                  30          
Asn Thr Cys Pro Pro Cys Pro
        35                  


<210> 755
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge sequence

<400> 755
Gln Glu Lys Glu Ala Ile Glu Arg Leu Lys Ala Ala Gly Ala Pro Glu
 1               5                  10                  15      
Ser Leu Val Ile Gln Ala Tyr Phe Ala Ser Glu Lys Asn Glu Asn Leu
            20                  25                  30          
Ala Ala Asn Phe Leu Leu Ser Gln Asn Phe Asp Asp Glu Cys Pro Pro
        35                  40                  45              
Cys Pro
    50  


<210> 756
<211> 52
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge sequence

<400> 756
Gln Glu Lys Glu Ala Ile Glu Arg Leu Lys Ala Ala Gly Ala Pro Glu
 1               5                  10                  15      
Ser Leu Val Ile Gln Ala Tyr Phe Ala Ser Glu Lys Asn Glu Asn Leu
            20                  25                  30          
Ala Ala Asn Phe Leu Leu Ser Gln Asn Phe Asp Asp Glu Cys Pro Pro
        35                  40                  45              
Cys Pro Ser Gly
    50          


<210> 757
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge sequence

<400> 757
Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser Ser
 1               5                  10                  15      
Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu Val
            20                  25                  30          
Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp Gly
        35                  40                  45              
Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu Gly
    50                  55                  60                  
Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His Trp
65                  70                  75                  80  
Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His Thr
                85                  90                  95      
Phe Glu Asp Ser Thr Lys Lys Ser Ala Cys Pro Pro Cys Pro
            100                 105                 110 


<210> 758
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge sequence

<400> 758
Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser Ser
 1               5                  10                  15      
Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu Val
            20                  25                  30          
Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp Gly
        35                  40                  45              
Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu Gly
    50                  55                  60                  
Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His Trp
65                  70                  75                  80  
Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His Thr
                85                  90                  95      
Phe Glu Asp Ser Thr Lys Lys Ser Ala Cys Pro Pro Cys Ser Gly
            100                 105                 110     


<210> 759
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge sequence

<400> 759
Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp
 1               5                  10                  15      
Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr
            20                  25                  30          
Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly Lys
        35                  40                  45              
Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala Lys
    50                  55                  60                  
Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys
65                  70                  75                  80  
Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp His
                85                  90                  95      
Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Ser Val Pro Cys
            100                 105                 110         
Pro Pro Cys Pro
        115     

<210> 760
<211> 1086
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0294 (hinge-CH2-CH3-Ck DAE)

<400> 760
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt      60
tccagcgagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctgaa     120
gccgcgggtg caccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     180
tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     240
aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     300
gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     360
ctgaatggca aggcgtacgc gtgcgcggtc tccaacaaag ccctcccagc ccccatcgag     420
aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     480
tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     540
ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     600
acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     660
aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     720
aaccactaca cgcagaagag cctctccctg tctccgggta aatctagaac tgtggctgca     780
ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac tgcctctgtt     840
gtgtgcctgc tgaatgactt ctatcccaga gaggccaaag tacagtggaa ggtggataac     900
gccctccaat cgggtaactc ccaggagagt gccacagagc aggacagcaa ggacagcacc     960
tacagcctca gcagcgagct gacgctgagc aaagcagact acgagaaaca caaagtctac    1020
gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga    1080
gagtga                                                               1086

<210> 761
<211> 1086
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0296 (hinge-CH2-CH3-Ck MAE)

<400> 761
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt      60
tccagcgagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctgaa     120
gccgcgggtg caccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     180
tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     240
aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     300
gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     360
ctgaatggca aggcgtacgc gtgcgcggtc tccaacaaag ccctcccagc ccccatcgag     420
aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     480
tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     540
ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     600
acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     660
aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     720
aaccactaca cgcagaagag cctctccctg tctccgggta aatctagaac tgtggctgca     780
ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac tgcctctgtt     840
gtgtgcctgc tgaatatgtt ctatcccaga gaggccaaag tacagtggaa ggtggataac     900
gccctccaat cgggtaactc ccaggagagt gccacagagc aggacagcaa ggacagcacc     960
tacagcctca gcagcgagct gacgctgagc aaagcagact acgagaaaca caaagtctac    1020
gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga    1080
gagtga                                                               1086

<210> 762
<211> 1086
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0297 (hinge-CH2-CH3-Ck SAE)

<400> 762
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt      60
tccagcgagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctgaa     120
gccgcgggtg caccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     180
tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     240
aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     300
gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     360
ctgaatggca aggcgtacgc gtgcgcggtc tccaacaaag ccctcccagc ccccatcgag     420
aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     480
tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     540
ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     600
acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     660
aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     720
aaccactaca cgcagaagag cctctccctg tctccgggta aatctagaac tgtggctgca     780
ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac tgcctctgtt     840
gtgtgcctgc tgaatagctt ctatcccaga gaggccaaag tacagtggaa ggtggataac     900
gccctccaat cgggtaactc ccaggagagt gccacagagc aggacagcaa ggacagcacc     960
tacagcctca gcagcgagct gacgctgagc aaagcagact acgagaaaca caaagtctac    1020
gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga    1080
gagtga                                                               1086

<210> 763
<211> 1086
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0298 (hinge-CH2-CH3-Ck FAE)

<400> 763
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt      60
tccagcgagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctgaa     120
gccgcgggtg caccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     180
tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     240
aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     300
gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     360
ctgaatggca aggcgtacgc gtgcgcggtc tccaacaaag ccctcccagc ccccatcgag     420
aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     480
tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     540
ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     600
acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     660
aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     720
aaccactaca cgcagaagag cctctccctg tctccgggta aatctagaac tgtggctgca     780
ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac tgcctctgtt     840
gtgtgcctgc tgaatttctt ctatcccaga gaggccaaag tacagtggaa ggtggataac     900
gccctccaat cgggtaactc ccaggagagt gccacagagc aggacagcaa ggacagcacc     960
tacagcctca gcagcgagct gacgctgagc aaagcagact acgagaaaca caaagtctac    1020
gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga    1080
gagtga                                                               1086

<210> 764
<211> 1800
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0303 (Cris7 scFv-hinge-CH2-CH3-CH1)

<400> 764
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt      60
caggtccagc tggtgcagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg     120
tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc     180
cctggaaagg gtctggaatg gattggatac attaatccta gcagtgctta tactaattac     240
aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc     300
ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa     360
gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct     420
agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc     480
cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc     540
tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc cggcaaggcc     600
cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt     660
ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc     720
gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag     780
ctacaaatta cacgctcgag tgagcccaaa tcttctgaca aaactcacac atgcccaccg     840
tgcccagcac ctgaagccgc gggtgcaccg tcagtcttcc tcttcccccc aaaacccaag     900
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac     960
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag    1020
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc    1080
ctgcaccagg actggctgaa tggcaaggcg tacgcgtgcg cggtctccaa caaagccctc    1140
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg    1200
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg    1260
gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag    1320
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc    1380
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg    1440
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaatct    1500
agagcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct    1560
gggggcacag cggccctggg ctgcctggtc aaggactact tccccgagcc ggtgacggtg    1620
tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc    1680
tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag    1740
acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagtttga    1800

<210> 765
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0294 (hinge-CH2-CH3-Ck DAE)

<400> 765
Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys
 1               5                  10                  15
Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro
            20                  25                  30
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
        35                  40                  45
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
    50                  55                  60
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
65                  70                  75                  80
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
                85                  90                  95
His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn
            100                 105                 110
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
        115                 120                 125
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    130                 135                 140
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
145                 150                 155                 160
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                165                 170                 175
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            180                 185                 190
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        195                 200                 205
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    210                 215                 220
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Thr Val Ala Ala
225                 230                 235                 240
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
                245                 250                 255
Thr Ala Ser Val Val Cys Leu Leu Asn Asp Phe Tyr Pro Arg Glu Ala
            260                 265                 270
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
        275                 280                 285
Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
    290                 295                 300
Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
305                 310                 315                 320
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
                325                 330                 335
Phe Asn Arg Gly Glu
            340

<210> 766
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0296 (hinge-CH2-CH3-Ck MAE)

<400> 766
Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys
 1               5                  10                  15
Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro
            20                  25                  30
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
        35                  40                  45
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
    50                  55                  60
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
65                  70                  75                  80
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
                85                  90                  95
His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn
            100                 105                 110
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
        115                 120                 125
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    130                 135                 140
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
145                 150                 155                 160
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                165                 170                 175
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            180                 185                 190
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        195                 200                 205
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    210                 215                 220
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Thr Val Ala Ala
225                 230                 235                 240
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
                245                 250                 255
Thr Ala Ser Val Val Cys Leu Leu Asn Met Phe Tyr Pro Arg Glu Ala
            260                 265                 270
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
        275                 280                 285
Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
    290                 295                 300
Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
305                 310                 315                 320
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
                325                 330                 335
Phe Asn Arg Gly Glu
            340

<210> 767
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0297 (hinge-CH2-CH3-Ck SAE)

<400> 767
Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys
 1               5                  10                  15
Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro
            20                  25                  30
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
        35                  40                  45
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
    50                  55                  60
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
65                  70                  75                  80
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
                85                  90                  95
His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn
            100                 105                 110
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
        115                 120                 125
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    130                 135                 140
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
145                 150                 155                 160
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                165                 170                 175
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            180                 185                 190
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        195                 200                 205
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    210                 215                 220
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Thr Val Ala Ala
225                 230                 235                 240
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
                245                 250                 255
Thr Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Arg Glu Ala
            260                 265                 270
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
        275                 280                 285
Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
    290                 295                 300
Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
305                 310                 315                 320
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
                325                 330                 335
Phe Asn Arg Gly Glu
            340

<210> 768
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0298 (hinge-CH2-CH3-Ck FAE)

<400> 768
Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys
 1               5                  10                  15
Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro
            20                  25                  30
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
        35                  40                  45
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
    50                  55                  60
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
65                  70                  75                  80
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
                85                  90                  95
His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn
            100                 105                 110
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
        115                 120                 125
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    130                 135                 140
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
145                 150                 155                 160
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                165                 170                 175
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            180                 185                 190
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        195                 200                 205
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    210                 215                 220
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Thr Val Ala Ala
225                 230                 235                 240
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
                245                 250                 255
Thr Ala Ser Val Val Cys Leu Leu Asn Phe Phe Tyr Pro Arg Glu Ala
            260                 265                 270
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
        275                 280                 285
Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
    290                 295                 300
Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
305                 310                 315                 320
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
                325                 330                 335
Phe Asn Arg Gly Glu
            340

<210> 769
<211> 579
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0303 (Cris7 scFv-hinge-CH2-CH3-CH1)

<400> 769
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser
            20                  25                  30
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45
Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60
Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe
65                  70                  75                  80
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
                85                  90                  95
Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly
            100                 105                 110
Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125
Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln
    130                 135                 140
Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr
145                 150                 155                 160
Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys
                165                 170                 175
Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala
            180                 185                 190
Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr
        195                 200                 205
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr
    210                 215                 220
Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys
225                 230                 235                 240
Leu Gln Ile Thr Arg Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His
                245                 250                 255
Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val
            260                 265                 270
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
        275                 280                 285
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
    290                 295                 300
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
305                 310                 315                 320
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
                325                 330                 335
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala
            340                 345                 350
Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
        355                 360                 365
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
    370                 375                 380
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
385                 390                 395                 400
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
                405                 410                 415
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
            420                 425                 430
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
        435                 440                 445
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
    450                 455                 460
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser
465                 470                 475                 480
Arg Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
                485                 490                 495
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
            500                 505                 510
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
        515                 520                 525
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
    530                 535                 540
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
545                 550                 555                 560
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
                565                 570                 575
Lys Lys Val


<210> 770
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutated human Ck DAE

<400> 770
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asp Phe Tyr
            20                  25                  30
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60
Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105

<210> 771
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutated human Ck MAE

<400> 771
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Met Phe Tyr
            20                  25                  30
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60
Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105

<210> 772
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutated human Ck SAE

<400> 772
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr
            20                  25                  30
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60
Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105

<210> 773
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutated human FAE

<400> 773
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Phe Phe Tyr
            20                  25                  30
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45
Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60
Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105

<210> 774
<211> 1086
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0299 (hinge-CH2-CH3-Ck L29E)

<400> 774
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt      60
tccagcgagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctgaa     120
gccgcgggtg caccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     180
tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     240
aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     300
gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     360
ctgaatggca aggcgtacgc gtgcgcggtc tccaacaaag ccctcccagc ccccatcgag     420
aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     480
tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     540
ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     600
acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     660
aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     720
aaccactaca cgcagaagag cctctccctg tctccgggta aatctagaac tgtggctgca     780
ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac tgcctctgtt     840
gtgtgcgagc tgaataactt ctatcccaga gaggccaaag tacagtggaa ggtggataac     900
gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa ggacagcacc     960
tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca caaagtctac    1020
gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga    1080
gagtga                                                               1086

<210> 775
<211> 1086
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0300 (hinge-CH2-CH3-Ck L29K)

<400> 775
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt      60
tccagcgagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctgaa     120
gccgcgggtg caccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     180
tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     240
aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     300
gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     360
ctgaatggca aggcgtacgc gtgcgcggtc tccaacaaag ccctcccagc ccccatcgag     420
aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     480
tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     540
ccaagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     600
acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     660
aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     720
aaccactaca cgcagaagag cctctccctg tctccgggta aatctagaac tgtggctgca     780
ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac tgcctctgtt     840
gtgtgcaagc tgaataactt ctatcccaga gaggccaaag tacagtggaa ggtggataac     900
gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa ggacagcacc     960
tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca caaagtctac    1020
gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga    1080
gagtga                                                               1086

<210> 776
<211> 1800
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0301 (Cris7 scFv-hinge-CH2-CH3-CH1 V68E)

<400> 776
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt      60
caggtccagc tggtgcagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg     120
tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc     180
cctggaaagg gtctggaatg gattggatac attaatccta gcagtgctta tactaattac     240
aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc     300
ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa     360
gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct     420
agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc     480
cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc     540
tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc cggcaaggcc     600
cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt     660
ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc     720
gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag     780
ctacaaatta cacgctcgag tgagcccaaa tcttctgaca aaactcacac atgcccaccg     840
tgcccagcac ctgaagccgc gggtgcaccg tcagtcttcc tcttcccccc aaaacccaag     900
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac     960
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag    1020
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc    1080
ctgcaccagg actggctgaa tggcaaggcg tacgcgtgcg cggtctccaa caaagccctc    1140
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg    1200
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg    1260
gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag    1320
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc    1380
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg    1440
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaatct    1500
agagcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct    1560
gggggcacag cggccctggg ctgcctggtc aaggactact tccccgagcc ggtgacggtg    1620
tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc    1680
tcaggactct actccctcag cagcgaggtg accgtgccct ccagcagctt gggcacccag    1740
acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagtttga    1800

<210> 777
<211> 1800
<212> DNA
<213> Artificial Sequence

<220> 
<223> X0302 (Cris7 scFv-hinge-CH2-CH3-CH1 V68K)

<400> 777
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt      60
caggtccagc tggtgcagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg     120
tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc     180
cctggaaagg gtctggaatg gattggatac attaatccta gcagtgctta tactaattac     240
aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc     300
ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa     360
gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct     420
agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc     480
cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc     540
tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc cggcaaggcc     600
cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt     660
ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc     720
gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag     780
ctacaaatta cacgctcgag tgagcccaaa tcttctgaca aaactcacac atgcccaccg     840
tgcccagcac ctgaagccgc gggtgcaccg tcagtcttcc tcttcccccc aaaacccaag     900
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac     960
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag    1020
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc    1080
ctgcaccagg actggctgaa tggcaaggcg tacgcgtgcg cggtctccaa caaagccctc    1140
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg    1200
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg    1260
gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag    1320
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc    1380
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg    1440
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaatct    1500
agagcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct    1560
gggggcacag cggccctggg ctgcctggtc aaggactact tccccgagcc ggtgacggtg    1620
tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc    1680
tcaggactct actccctcag cagcaaggtg accgtgccct ccagcagctt gggcacccag    1740
acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagtttga    1800

<210> 778
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0299 (hinge-CH2-CH3-Ck L29E)

<400> 778
Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys
 1               5                  10                  15
Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro
            20                  25                  30
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
        35                  40                  45
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
    50                  55                  60
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
65                  70                  75                  80
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
                85                  90                  95
His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn
            100                 105                 110
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
        115                 120                 125
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    130                 135                 140
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
145                 150                 155                 160
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                165                 170                 175
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            180                 185                 190
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        195                 200                 205
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    210                 215                 220
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Thr Val Ala Ala
225                 230                 235                 240
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
                245                 250                 255
Thr Ala Ser Val Val Cys Glu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
            260                 265                 270
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
        275                 280                 285
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
    290                 295                 300
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
305                 310                 315                 320
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
                325                 330                 335
Phe Asn Arg Gly Glu
            340

<210> 779
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0300 (hinge-CH2-CH3-Ck L29K)

<400> 779
Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys
 1               5                  10                  15
Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro
            20                  25                  30
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
        35                  40                  45
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
    50                  55                  60
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
65                  70                  75                  80
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
                85                  90                  95
His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn
            100                 105                 110
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
        115                 120                 125
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    130                 135                 140
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
145                 150                 155                 160
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                165                 170                 175
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            180                 185                 190
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        195                 200                 205
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    210                 215                 220
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Thr Val Ala Ala
225                 230                 235                 240
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
                245                 250                 255
Thr Ala Ser Val Val Cys Lys Leu Asn Asn Phe Tyr Pro Arg Glu Ala
            260                 265                 270
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
        275                 280                 285
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
    290                 295                 300
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
305                 310                 315                 320
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
                325                 330                 335
Phe Asn Arg Gly Glu
            340

<210> 780
<211> 579
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0301 (Cris7 scFv-hinge-CH2-CH3-CH1 V68E)

<400> 780
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser
            20                  25                  30
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45
Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60
Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe
65                  70                  75                  80
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
                85                  90                  95
Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly
            100                 105                 110
Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125
Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln
    130                 135                 140
Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr
145                 150                 155                 160
Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys
                165                 170                 175
Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala
            180                 185                 190
Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr
        195                 200                 205
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr
    210                 215                 220
Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys
225                 230                 235                 240
Leu Gln Ile Thr Arg Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His
                245                 250                 255
Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val
            260                 265                 270
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
        275                 280                 285
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
    290                 295                 300
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
305                 310                 315                 320
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
                325                 330                 335
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala
            340                 345                 350
Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
        355                 360                 365
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
    370                 375                 380
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
385                 390                 395                 400
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
                405                 410                 415
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
            420                 425                 430
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
        435                 440                 445
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
    450                 455                 460
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser
465                 470                 475                 480
Arg Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
                485                 490                 495
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
            500                 505                 510
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
        515                 520                 525
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
    530                 535                 540
Ser Leu Ser Ser Glu Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
545                 550                 555                 560
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
                565                 570                 575
Lys Lys Val


<210> 781
<211> 579
<212> PRT
<213> Artificial Sequence

<220> 
<223> X0302 (Cris7 scFv-hinge-CH2-CH3-CH1 V68K)

<400> 781
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser
            20                  25                  30
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45
Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60
Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe
65                  70                  75                  80
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
                85                  90                  95
Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly
            100                 105                 110
Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125
Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln
    130                 135                 140
Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr
145                 150                 155                 160
Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys
                165                 170                 175
Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala
            180                 185                 190
Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr
        195                 200                 205
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr
    210                 215                 220
Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys
225                 230                 235                 240
Leu Gln Ile Thr Arg Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His
                245                 250                 255
Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val
            260                 265                 270
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
        275                 280                 285
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
    290                 295                 300
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
305                 310                 315                 320
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
                325                 330                 335
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala
            340                 345                 350
Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
        355                 360                 365
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
    370                 375                 380
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
385                 390                 395                 400
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
                405                 410                 415
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
            420                 425                 430
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
        435                 440                 445
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
    450                 455                 460
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser
465                 470                 475                 480
Arg Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
                485                 490                 495
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
            500                 505                 510
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
        515                 520                 525
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
    530                 535                 540
Ser Leu Ser Ser Lys Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
545                 550                 555                 560
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
                565                 570                 575
Lys Lys Val


<210> 782
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutated Ck L29E

<400> 782
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Glu Leu Asn Asn Phe Tyr
            20                  25                  30
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105

<210> 783
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutated Ck L29K

<400> 783
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Lys Leu Asn Asn Phe Tyr
            20                  25                  30
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95
Val Thr Lys Ser Phe Asn Arg Gly Glu
            100                 105

<210> 784
<211> 98
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutated CH1 V68E

<400> 784
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60
Leu Ser Ser Glu Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95
Lys Val


<210> 785
<211> 98
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutated CH1 V68K

<400> 785
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60
Leu Ser Ser Lys Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95
Lys Val


<210> 786
<211> 245
<212> PRT
<213> Artificial Sequence

<220> 
<223> HuCris7 (VH3-VL1) scFv

<400> 786
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser
            20                  25                  30
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45
Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60
Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe
65                  70                  75                  80
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
                85                  90                  95
Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly
            100                 105                 110
Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125
Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln
    130                 135                 140
Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr
145                 150                 155                 160
Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys
                165                 170                 175
Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala
            180                 185                 190
Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr
        195                 200                 205
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr
    210                 215                 220
Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys
225                 230                 235                 240
Leu Gln Ile Thr Arg
                245

<210> 787
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> CH3-CH1 linker or CH3-Ck linker

<400> 787
Lys Ser Arg
 1

<210> 788
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CH3-CH1 linker

<400> 788
Gly Gly Gly Ser Ser
 1               5

<210> 789
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> CH3-CH1 linker

<400> 789
Ser Tyr Ser Pro Asn Ser
 1               5

<210> 790
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CH3-CH1 linker

<400> 790
Ser Ser Leu Asn Thr Pro Asn Ser
 1               5

<210> 791
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CH3-Ck linker

<400> 791
Gly Gly Gly Ser Arg
 1               5

<210> 792
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CH3-Ck linker

<400> 792
Ser Tyr Ser Pro Asn Ser Arg
 1               5

<210> 793
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CH3-Ck linker

<400> 793
Ser Ser Leu Asn Thr Pro Asn Ser Arg
 1               5

<210> 794
<211> 106
<212> PRT
<213> Homo sapiens

<400> 794
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
 1               5                  10                  15
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
65                  70                  75                  80
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
            100                 105

<210> 795
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG1 CH2 CH3 Null2 desLys

<400> 795
Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80
Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys
                85                  90                  95
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
            100                 105                 110
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
        115                 120                 125
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    130                 135                 140
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
145                 150                 155                 160
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
                165                 170                 175
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            180                 185                 190
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        195                 200                 205
Lys Ser Leu Ser Leu Ser Pro Gly
    210                 215

<210> 796
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 796
Ser Pro Pro Ser Pro Asn Ser
 1               5

<210> 797
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 797
Glu Pro Thr Ser Thr Asp Lys Thr His Thr Ser Pro Pro Ser Pro Asn
 1               5                  10                  15
Ser


<210> 798
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 798
Glu Pro Thr Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn
 1               5                  10                  15
Ser


<210> 799
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 799
Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn Ser
 1               5                  10                  15

<210> 800
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 800
Asn Ser Gly Ala Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr
 1               5                  10                  15
Ser Pro Asn Ser
            20

<210> 801
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 801
Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn Ser
 1               5                  10

<210> 802
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 802
Asn Ser Gly Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr
 1               5                  10                  15
Ser Pro Asn Ser
            20

<210> 803
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 803
Asn Ser Leu Ala Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr
 1               5                  10                  15
Ser Pro Asn Ser
            20

<210> 804
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 804
Asn Ser Leu Phe Ser Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr
 1               5                  10                  15
Ser Pro Asn Ser
            20

<210> 805
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 805
Asn Ser Leu Ala Ser Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr
 1               5                  10                  15
Ser Pro Asn Ser
            20

<210> 806
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 806
Glu Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr
 1               5                  10                  15
Ser Gly Ser Ala Asp Thr Ser Pro Asn Ser
            20                  25

<210> 807
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 807
Gln Arg His Ala Asn Ser Ala Leu Asn Thr Gly Thr Gln Met Ala Gly
 1               5                  10                  15
His Ser Pro Asn Ser
            20

<210> 808
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 808
Gln Arg His Asn Ala Ala Ser Leu Asn Thr Gly Thr Gln Met Ala Gly
 1               5                  10                  15
His Ser Pro Asn Ser
            20

<210> 809
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 809
Gln Arg His Ala Ala Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly
 1               5                  10                  15
His Ser Pro Asn Ser
            20

<210> 810
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 810
Gln Arg His Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser
 1               5                  10                  15
Pro Asn Ser


<210> 811
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 811
Gln Arg His Gly Gly Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly
 1               5                  10                  15
His Ser Pro Asn Ser
            20

<210> 812
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 812
His Asp Gly Ser Ser Leu Asn Thr Pro Asn Ser
 1               5                  10

<210> 813
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 813
Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser
 1               5                  10                  15

<210> 814
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 814
Ser Ser Leu Asn Thr Arg Thr Gln Met Ala Gly His Ser Pro Asn Ser
 1               5                  10                  15

<210> 815
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 815
Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Arg His Ser Pro Asn Ser
 1               5                  10                  15

<210> 816
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 816
Ser Ser Leu Asn Thr Gly Thr Gln Lys Ala Gly His Ser Pro Asn Ser
 1               5                  10                  15

<210> 817
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 817
Ser Ser Leu Asn Thr Gly Thr Gln Lys Ala Arg His Ser Pro Asn Ser
 1               5                  10                  15

<210> 818
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 818
Ser Ser Leu Asn Thr Arg Thr Gln Met Ala Arg His Ser Pro Asn Ser
 1               5                  10                  15

<210> 819
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 819
Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Gly His Ser Pro Asn Ser
 1               5                  10                  15

<210> 820
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 820
Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Pro Asn
 1               5                  10                  15
Ser


<210> 821
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 821
Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Pro Asn Ser
 1               5                  10

<210> 822
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 822
Asn Ser Leu Phe Asn Gln Glu Val Pro Asn Ser
 1               5                  10

<210> 823
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 823
Gln Arg His Asn Asn Ser Ser Leu Asn Thr Pro Asn Ser
 1               5                  10

<210> 824
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide linker

<400> 824
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15
Pro Asn Ser


<210> 825
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> H68 linker (scorpion linker derived from NKG2D)

<400> 825
Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr
 1               5                  10                  15
Ser Pro Asn Ser
            20

<210> 826
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 134

<400> 826
Glu Pro Met Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 827
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 135

<400> 827
Glu Pro Met Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 828
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 136

<400> 828
Glu Pro Met Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro
 1               5                  10                  15

<210> 829
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 137

<400> 829
Glu Pro Met Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Pro
 1               5                  10                  15

<210> 830
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 138

<400> 830
Glu Pro Met Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro
 1               5                  10                  15

<210> 831
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 139

<400> 831
Glu Pro Met Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro
 1               5                  10                  15

<210> 832
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 140

<400> 832
Glu Pro Met Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro
 1               5                  10                  15

<210> 833
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 141

<400> 833
Glu Pro Met Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Ser
 1               5                  10                  15

<210> 834
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 142

<400> 834
Glu Pro Met Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser
 1               5                  10                  15

<210> 835
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 143

<400> 835
Glu Pro Met Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser
 1               5                  10                  15

<210> 836
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 144

<400> 836
Glu Pro Met Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Ser
 1               5                  10                  15

<210> 837
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 145

<400> 837
Glu Pro Met Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser
 1               5                  10                  15

<210> 838
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 146

<400> 838
Glu Pro Met Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro
 1               5                  10                  15

<210> 839
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 147

<400> 839
Glu Pro Met Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser
 1               5                  10                  15

<210> 840
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 148

<400> 840
Glu Pro Thr Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 841
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 149

<400> 841
Glu Pro Thr Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 842
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 150

<400> 842
Glu Pro Thr Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro
 1               5                  10                  15

<210> 843
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 151

<400> 843
Glu Pro Thr Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Pro
 1               5                  10                  15

<210> 844
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 152

<400> 844
Glu Pro Thr Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro
 1               5                  10                  15

<210> 845
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 153

<400> 845
Glu Pro Thr Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro
 1               5                  10                  15

<210> 846
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 154

<400> 846
Glu Pro Thr Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro
 1               5                  10                  15

<210> 847
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 155

<400> 847
Glu Pro Thr Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Ser
 1               5                  10                  15

<210> 848
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 156

<400> 848
Glu Pro Thr Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser
 1               5                  10                  15

<210> 849
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 157

<400> 849
Glu Pro Thr Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser
 1               5                  10                  15

<210> 850
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 158

<400> 850
Glu Pro Thr Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Ser
 1               5                  10                  15

<210> 851
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 159

<400> 851
Glu Pro Thr Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser
 1               5                  10                  15

<210> 852
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 160

<400> 852
Glu Pro Thr Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser
 1               5                  10                  15

<210> 853
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 161

<400> 853
Glu Pro Thr Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser
 1               5                  10                  15

<210> 854
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 162

<400> 854
Glu Pro Ala Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 855
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 163

<400> 855
Glu Pro Ala Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 856
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 164

<400> 856
Glu Pro Ala Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro
 1               5                  10                  15

<210> 857
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 165

<400> 857
Glu Pro Ala Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Pro
 1               5                  10                  15

<210> 858
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 166

<400> 858
Glu Pro Ala Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro
 1               5                  10                  15

<210> 859
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 167

<400> 859
Glu Pro Ala Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro
 1               5                  10                  15

<210> 860
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 168

<400> 860
Glu Pro Ala Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro
 1               5                  10                  15

<210> 861
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 169

<400> 861
Glu Pro Ala Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Ser
 1               5                  10                  15

<210> 862
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 170

<400> 862
Glu Pro Ala Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser
 1               5                  10                  15

<210> 863
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 171

<400> 863
Glu Pro Ala Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser
 1               5                  10                  15

<210> 864
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 172

<400> 864
Glu Pro Ala Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Ser
 1               5                  10                  15

<210> 865
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 173

<400> 865
Glu Pro Ala Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser
 1               5                  10                  15

<210> 866
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 174

<400> 866
Glu Pro Ala Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser
 1               5                  10                  15

<210> 867
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 175

<400> 867
Glu Pro Ala Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser
 1               5                  10                  15

<210> 868
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 176

<400> 868
Glu Pro Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10

<210> 869
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 177

<400> 869
Glu Pro Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10

<210> 870
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 178

<400> 870
Glu Pro Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro
 1               5                  10

<210> 871
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 179

<400> 871
Glu Pro Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Pro
 1               5                  10

<210> 872
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 180

<400> 872
Glu Pro Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro
 1               5                  10

<210> 873
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 181

<400> 873
Glu Pro Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro
 1               5                  10

<210> 874
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 182

<400> 874
Glu Pro Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro
 1               5                  10

<210> 875
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 183

<400> 875
Glu Pro Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Ser
 1               5                  10

<210> 876
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 184

<400> 876
Glu Pro Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser
 1               5                  10

<210> 877
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 185

<400> 877
Glu Pro Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser
 1               5                  10

<210> 878
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 186

<400> 878
Glu Pro Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Ser
 1               5                  10

<210> 879
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 187

<400> 879
Glu Pro Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser
 1               5                  10

<210> 880
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 188

<400> 880
Glu Pro Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser
 1               5                  10

<210> 881
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 189

<400> 881
Glu Pro Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser
 1               5                  10

<210> 882
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> G1 N297A  CH2-CH3 (N297ST - A297ST)

<400> 882
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60
Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
            100                 105                 110
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
        115                 120                 125
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    130                 135                 140
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
145                 150                 155                 160
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
                165                 170                 175
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            180                 185                 190
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        195                 200                 205
Lys Ser Leu Ser Leu Ser Pro Gly Lys
    210                 215

<210> 883
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG1 AA N297A CH2CH3 (Ala substitutions at 234,
      235, 237 and 297; 236 deleted)

<400> 883
Ala Pro Glu Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
 1               5                  10                  15
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
            20                  25                  30
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
        35                  40                  45
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
    50                  55                  60
Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
65                  70                  75                  80
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
                85                  90                  95
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
            100                 105                 110
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
        115                 120                 125
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
    130                 135                 140
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
145                 150                 155                 160
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
                165                 170                 175
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
            180                 185                 190
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
        195                 200                 205
Ser Leu Ser Leu Ser Pro Gly Lys
    210                 215

<210> 884
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> G2 AA N297A CH2CH3 (Ala substitution at 234, 236
      and 297)

<400> 884
Ala Pro Glu Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
 1               5                  10                  15
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
            20                  25                  30
Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
        35                  40                  45
Asp Gly Met Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
    50                  55                  60
Phe Ala Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln
65                  70                  75                  80
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
                85                  90                  95
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro
            100                 105                 110
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
        115                 120                 125
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
    130                 135                 140
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
145                 150                 155                 160
Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
                165                 170                 175
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
            180                 185                 190
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
        195                 200                 205
Ser Leu Ser Leu Ser Pro Gly Lys
    210                 215

<210> 885
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> G4 AA N297A CH2CH3 (Ala substitutions at 234, 235,
      237 and 297; 236 deleted)

<400> 885
Ala Pro Glu Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
 1               5                  10                  15
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
            20                  25                  30
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
        35                  40                  45
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
    50                  55                  60
Phe Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
65                  70                  75                  80
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
                85                  90                  95
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
            100                 105                 110
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr
        115                 120                 125
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
    130                 135                 140
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
145                 150                 155                 160
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
                165                 170                 175
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe
            180                 185                 190
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
        195                 200                 205
Ser Leu Ser Leu Ser Pro Gly Lys
    210                 215

<210> 886
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> HM1 (IgM CH3:IgG1 CH3) without C-terminal tail

<400> 886
Asp Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala
 1               5                  10                  15
Ser Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp
            20                  25                  30
Leu Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly
        35                  40                  45
Glu Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala
    50                  55                  60
Thr Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn
65                  70                  75                  80
Ser Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser
                85                  90                  95
Pro Leu Lys Gln Thr Ile Ser Arg Pro Lys Gly Gln Pro Arg Glu Pro
            100                 105                 110
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
        115                 120                 125
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
    130                 135                 140
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
145                 150                 155                 160
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                165                 170                 175
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
            180                 185                 190
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
        195                 200                 205
Leu Ser Pro Gly Lys
    210

<210> 887
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 CH2 CH3 Null2

<400> 887
Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80
Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys
                85                  90                  95
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
            100                 105                 110
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
        115                 120                 125
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    130                 135                 140
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
145                 150                 155                 160
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
                165                 170                 175
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            180                 185                 190
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        195                 200                 205
Lys Ser Leu Ser Leu Ser Pro Gly Lys
    210                 215

<210> 888
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> Half null CH2-CH3 regions

<400> 888
Pro Asp Ala Ala Gly Ala Pro Ser Val Phe Ile Phe Pro Pro Lys Ile
 1               5                  10                  15
Lys Asp Val Leu Met Ile Ser Leu Ser Pro Met Val Thr Cys Val Val
            20                  25                  30
Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val
        35                  40                  45
Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp
    50                  55                  60
Tyr Ala Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln
65                  70                  75                  80
Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Arg Ala
                85                  90                  95
Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Arg Gly Pro Val
            100                 105                 110
Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Ala Glu Glu Met Thr
        115                 120                 125
Lys Lys Glu Phe Ser Leu Thr Cys Met Ile Thr Gly Phe Leu Pro Ala
    130                 135                 140
Glu Ile Ala Val Asp Trp Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr
145                 150                 155                 160
Lys Asn Thr Ala Thr Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr
                165                 170                 175
Ser Lys Leu Arg Val Gln Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe
            180                 185                 190
Ala Cys Ser Val Val His Glu Gly Leu His Asn His Leu Thr Thr Lys
        195                 200                 205
Thr Ile Ser Arg Ser Leu Gly Lys
    210                 215

<210> 889
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> HM2 (mouse CH3mu-CH3gamma) without C-termial tail

<400> 889
Ser Pro Ser Thr Asp Ile Leu Thr Phe Thr Ile Pro Pro Ser Phe Ala
 1               5                  10                  15
Asp Ile Phe Leu Ser Lys Ser Ala Asn Leu Thr Cys Leu Val Ser Asn
            20                  25                  30
Leu Ala Thr Tyr Glu Thr Leu Asn Ile Ser Trp Ala Ser Gln Ser Gly
        35                  40                  45
Glu Pro Leu Glu Thr Lys Ile Lys Ile Met Glu Ser His Pro Asn Gly
    50                  55                  60
Thr Phe Ser Ala Lys Gly Val Ala Ser Val Cys Val Glu Asp Trp Asn
65                  70                  75                  80
Asn Arg Lys Glu Phe Val Cys Thr Val Thr His Arg Asp Leu Pro Ser
                85                  90                  95
Pro Gln Lys Lys Phe Ile Ser Lys Pro Asn Gly Pro Val Arg Ala Pro
            100                 105                 110
Gln Val Tyr Val Leu Pro Pro Pro Ala Glu Glu Met Thr Lys Lys Glu
        115                 120                 125
Phe Ser Leu Thr Cys Met Ile Thr Gly Phe Leu Pro Ala Glu Ile Ala
    130                 135                 140
Val Asp Trp Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr Lys Asn Thr
145                 150                 155                 160
Ala Thr Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu
                165                 170                 175
Arg Val Gln Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe Ala Cys Ser
            180                 185                 190
Val Val His Glu Gly Leu His Asn His Leu Thr Thr Lys Thr Ile Ser
        195                 200                 205
Arg Ser Leu Gly Lys
    210
