                              Sequence Listing

<110> GENENTECH, INC. et al.

<120> Delivery System For Diagnostic And Therapeutic Agents

<130> P4399R1-WO

<141> 2011-01-21

<160> 4

<210> 1
<211> 963
<212> PRT
<213> Homo sapiens

<400> 1
 Met Gly Leu Pro Glu Pro Gly Pro Leu Arg Leu Leu Ala Leu Leu
   1               5                  10                  15

 Leu Leu Leu Leu Leu Leu Leu Leu Leu Arg Leu Gln His Leu Ala
                  20                  25                  30

 Ala Ala Ala Ala Asp Pro Leu Leu Gly Gly Gln Gly Pro Ala Lys
                  35                  40                  45

 Glu Cys Glu Lys Asp Gln Phe Gln Cys Arg Asn Glu Arg Cys Ile
                  50                  55                  60

 Pro Ser Val Trp Arg Cys Asp Glu Asp Asp Asp Cys Leu Asp His
                  65                  70                  75

 Ser Asp Glu Asp Asp Cys Pro Lys Lys Thr Cys Ala Asp Ser Asp
                  80                  85                  90

 Phe Thr Cys Asp Asn Gly His Cys Ile His Glu Arg Trp Lys Cys
                  95                 100                 105

 Asp Gly Glu Glu Glu Cys Pro Asp Gly Ser Asp Glu Ser Glu Ala
                 110                 115                 120

 Thr Cys Thr Lys Gln Val Cys Pro Ala Glu Lys Leu Ser Cys Gly
                 125                 130                 135

 Pro Thr Ser His Lys Cys Val Pro Ala Ser Trp Arg Cys Asp Gly
                 140                 145                 150

 Glu Lys Asp Cys Glu Gly Gly Ala Asp Glu Ala Gly Cys Ala Thr
                 155                 160                 165

 Leu Cys Ala Pro His Glu Phe Gln Cys Gly Asn Arg Ser Cys Leu
                 170                 175                 180

 Ala Ala Val Phe Val Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly
                 185                 190                 195

 Ser Asp Glu Arg Gly Cys Ala Asp Pro Ala Cys Gly Pro Arg Glu
                 200                 205                 210

 Phe Arg Cys Gly Gly Asp Gly Gly Gly Ala Cys Ile Pro Glu Arg
                 215                 220                 225

 Trp Val Cys Asp Arg Gln Phe Asp Cys Glu Asp Arg Ser Asp Glu
                 230                 235                 240

 Ala Ala Glu Leu Cys Gly Arg Pro Gly Pro Gly Ala Thr Ser Ala
                 245                 250                 255

 Pro Ala Ala Cys Ala Thr Val Ser Gln Phe Ala Cys Arg Ser Gly
                 260                 265                 270

 Glu Cys Val His Leu Gly Trp Arg Cys Asp Gly Asp Arg Asp Cys
                 275                 280                 285

 Lys Asp Lys Ser Asp Glu Ala Asp Cys Pro Leu Gly Thr Cys Arg
                 290                 295                 300

 Gly Asp Glu Phe Gln Cys Gly Asp Gly Thr Cys Val Leu Ala Ile
                 305                 310                 315

 Lys His Cys Asn Gln Glu Gln Asp Cys Pro Asp Gly Ser Asp Glu
                 320                 325                 330

 Ala Gly Cys Leu Gln Gly Leu Asn Glu Cys Leu His Asn Asn Gly
                 335                 340                 345

 Gly Cys Ser His Ile Cys Thr Asp Leu Lys Ile Gly Phe Glu Cys
                 350                 355                 360

 Thr Cys Pro Ala Gly Phe Gln Leu Leu Asp Gln Lys Thr Cys Gly
                 365                 370                 375

 Asp Ile Asp Glu Cys Lys Asp Pro Asp Ala Cys Ser Gln Ile Cys
                 380                 385                 390

 Val Asn Tyr Lys Gly Tyr Phe Lys Cys Glu Cys Tyr Pro Gly Tyr
                 395                 400                 405

 Glu Met Asp Leu Leu Thr Lys Asn Cys Lys Ala Ala Gly Gly Lys
                 410                 415                 420

 Ser Pro Ser Leu Ile Phe Thr Asn Arg Tyr Glu Val Arg Arg Ile
                 425                 430                 435

 Asp Leu Val Lys Arg Asn Tyr Ser Arg Leu Ile Pro Met Leu Lys
                 440                 445                 450

 Asn Val Val Ala Leu Asp Val Glu Val Ala Thr Asn Arg Ile Tyr
                 455                 460                 465

 Trp Cys Asp Leu Ser Tyr Arg Lys Ile Tyr Ser Ala Tyr Met Asp
                 470                 475                 480

 Lys Ala Ser Asp Pro Lys Glu Gln Glu Val Leu Ile Asp Glu Gln
                 485                 490                 495

 Leu His Ser Pro Glu Gly Leu Ala Val Asp Trp Val His Lys His
                 500                 505                 510

 Ile Tyr Trp Thr Asp Ser Gly Asn Lys Thr Ile Ser Val Ala Thr
                 515                 520                 525

 Val Asp Gly Gly Arg Arg Arg Thr Leu Phe Ser Arg Asn Leu Ser
                 530                 535                 540

 Glu Pro Arg Ala Ile Ala Val Asp Pro Leu Arg Gly Phe Met Tyr
                 545                 550                 555

 Trp Ser Asp Trp Gly Asp Gln Ala Lys Ile Glu Lys Ser Gly Leu
                 560                 565                 570

 Asn Gly Val Asp Arg Gln Thr Leu Val Ser Asp Asn Ile Glu Trp
                 575                 580                 585

 Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gln Arg Leu Tyr Trp
                 590                 595                 600

 Val Asp Ser Lys Leu His Gln Leu Ser Ser Ile Asp Phe Ser Gly
                 605                 610                 615

 Gly Asn Arg Lys Thr Leu Ile Ser Ser Thr Asp Phe Leu Ser His
                 620                 625                 630

 Pro Phe Gly Ile Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp
                 635                 640                 645

 Leu Glu Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Asn Gly Leu
                 650                 655                 660

 Glu Ile Ser Ile Leu Ala Glu Asn Leu Asn Asn Pro His Asp Ile
                 665                 670                 675

 Val Ile Phe His Glu Leu Lys Gln Pro Arg Ala Pro Asp Ala Cys
                 680                 685                 690

 Glu Leu Ser Val Gln Pro Asn Gly Gly Cys Glu Tyr Leu Cys Leu
                 695                 700                 705

 Pro Ala Pro Gln Ile Ser Ser His Ser Pro Lys Tyr Thr Cys Ala
                 710                 715                 720

 Cys Pro Asp Thr Met Trp Leu Gly Pro Asp Met Lys Arg Cys Tyr
                 725                 730                 735

 Arg Ala Pro Gln Ser Thr Ser Thr Thr Thr Leu Ala Ser Thr Met
                 740                 745                 750

 Thr Arg Thr Val Pro Ala Thr Thr Arg Ala Pro Gly Thr Thr Val
                 755                 760                 765

 His Arg Ser Thr Tyr Gln Asn His Ser Thr Glu Thr Pro Ser Leu
                 770                 775                 780

 Thr Ala Ala Val Pro Ser Ser Val Ser Val Pro Arg Ala Pro Ser
                 785                 790                 795

 Ile Ser Pro Ser Thr Leu Ser Pro Ala Thr Ser Asn His Ser Gln
                 800                 805                 810

 His Tyr Ala Asn Glu Asp Ser Lys Met Gly Ser Thr Val Thr Ala
                 815                 820                 825

 Ala Val Ile Gly Ile Ile Val Pro Ile Val Val Ile Ala Leu Leu
                 830                 835                 840

 Cys Met Ser Gly Tyr Leu Ile Trp Arg Asn Trp Lys Arg Lys Asn
                 845                 850                 855

 Thr Lys Ser Met Asn Phe Asp Asn Pro Val Tyr Arg Lys Thr Thr
                 860                 865                 870

 Glu Glu Glu Asp Glu Asp Glu Leu His Ile Gly Arg Thr Ala Gln
                 875                 880                 885

 Ile Gly His Val Tyr Pro Ala Ala Ile Ser Ser Phe Asp Arg Pro
                 890                 895                 900

 Leu Trp Ala Glu Pro Cys Leu Gly Glu Thr Arg Glu Pro Glu Asp
                 905                 910                 915

 Pro Ala Pro Ala Leu Lys Glu Leu Phe Val Leu Pro Gly Glu Pro
                 920                 925                 930

 Arg Ser Gln Leu His Gln Leu Pro Lys Asn Pro Leu Ser Glu Leu
                 935                 940                 945

 Pro Val Val Lys Ser Lys Arg Val Ala Leu Ser Leu Glu Asp Asp
                 950                 955                 960

 Gly Leu Pro
            

<210> 2
<211> 931
<212> PRT
<213> Homo sapiens

<400> 2
 Ala Ala Asp Pro Leu Leu Gly Gly Gln Gly Pro Ala Lys Glu Cys
   1               5                  10                  15

 Glu Lys Asp Gln Phe Gln Cys Arg Asn Glu Arg Cys Ile Pro Ser
                  20                  25                  30

 Val Trp Arg Cys Asp Glu Asp Asp Asp Cys Leu Asp His Ser Asp
                  35                  40                  45

 Glu Asp Asp Cys Pro Lys Lys Thr Cys Ala Asp Ser Asp Phe Thr
                  50                  55                  60

 Cys Asp Asn Gly His Cys Ile His Glu Arg Trp Lys Cys Asp Gly
                  65                  70                  75

 Glu Glu Glu Cys Pro Asp Gly Ser Asp Glu Ser Glu Ala Thr Cys
                  80                  85                  90

 Thr Lys Gln Val Cys Pro Ala Glu Lys Leu Ser Cys Gly Pro Thr
                  95                 100                 105

 Ser His Lys Cys Val Pro Ala Ser Trp Arg Cys Asp Gly Glu Lys
                 110                 115                 120

 Asp Cys Glu Gly Gly Ala Asp Glu Ala Gly Cys Ala Thr Leu Cys
                 125                 130                 135

 Ala Pro His Glu Phe Gln Cys Gly Asn Arg Ser Cys Leu Ala Ala
                 140                 145                 150

 Val Phe Val Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser Asp
                 155                 160                 165

 Glu Arg Gly Cys Ala Asp Pro Ala Cys Gly Pro Arg Glu Phe Arg
                 170                 175                 180

 Cys Gly Gly Asp Gly Gly Gly Ala Cys Ile Pro Glu Arg Trp Val
                 185                 190                 195

 Cys Asp Arg Gln Phe Asp Cys Glu Asp Arg Ser Asp Glu Ala Ala
                 200                 205                 210

 Glu Leu Cys Gly Arg Pro Gly Pro Gly Ala Thr Ser Ala Pro Ala
                 215                 220                 225

 Ala Cys Ala Thr Val Ser Gln Phe Ala Cys Arg Ser Gly Glu Cys
                 230                 235                 240

 Val His Leu Gly Trp Arg Cys Asp Gly Asp Arg Asp Cys Lys Asp
                 245                 250                 255

 Lys Ser Asp Glu Ala Asp Cys Pro Leu Gly Thr Cys Arg Gly Asp
                 260                 265                 270

 Glu Phe Gln Cys Gly Asp Gly Thr Cys Val Leu Ala Ile Lys His
                 275                 280                 285

 Cys Asn Gln Glu Gln Asp Cys Pro Asp Gly Ser Asp Glu Ala Gly
                 290                 295                 300

 Cys Leu Gln Gly Leu Asn Glu Cys Leu His Asn Asn Gly Gly Cys
                 305                 310                 315

 Ser His Ile Cys Thr Asp Leu Lys Ile Gly Phe Glu Cys Thr Cys
                 320                 325                 330

 Pro Ala Gly Phe Gln Leu Leu Asp Gln Lys Thr Cys Gly Asp Ile
                 335                 340                 345

 Asp Glu Cys Lys Asp Pro Asp Ala Cys Ser Gln Ile Cys Val Asn
                 350                 355                 360

 Tyr Lys Gly Tyr Phe Lys Cys Glu Cys Tyr Pro Gly Tyr Glu Met
                 365                 370                 375

 Asp Leu Leu Thr Lys Asn Cys Lys Ala Ala Gly Gly Lys Ser Pro
                 380                 385                 390

 Ser Leu Ile Phe Thr Asn Arg Tyr Glu Val Arg Arg Ile Asp Leu
                 395                 400                 405

 Val Lys Arg Asn Tyr Ser Arg Leu Ile Pro Met Leu Lys Asn Val
                 410                 415                 420

 Val Ala Leu Asp Val Glu Val Ala Thr Asn Arg Ile Tyr Trp Cys
                 425                 430                 435

 Asp Leu Ser Tyr Arg Lys Ile Tyr Ser Ala Tyr Met Asp Lys Ala
                 440                 445                 450

 Ser Asp Pro Lys Glu Gln Glu Val Leu Ile Asp Glu Gln Leu His
                 455                 460                 465

 Ser Pro Glu Gly Leu Ala Val Asp Trp Val His Lys His Ile Tyr
                 470                 475                 480

 Trp Thr Asp Ser Gly Asn Lys Thr Ile Ser Val Ala Thr Val Asp
                 485                 490                 495

 Gly Gly Arg Arg Arg Thr Leu Phe Ser Arg Asn Leu Ser Glu Pro
                 500                 505                 510

 Arg Ala Ile Ala Val Asp Pro Leu Arg Gly Phe Met Tyr Trp Ser
                 515                 520                 525

 Asp Trp Gly Asp Gln Ala Lys Ile Glu Lys Ser Gly Leu Asn Gly
                 530                 535                 540

 Val Asp Arg Gln Thr Leu Val Ser Asp Asn Ile Glu Trp Pro Asn
                 545                 550                 555

 Gly Ile Thr Leu Asp Leu Leu Ser Gln Arg Leu Tyr Trp Val Asp
                 560                 565                 570

 Ser Lys Leu His Gln Leu Ser Ser Ile Asp Phe Ser Gly Gly Asn
                 575                 580                 585

 Arg Lys Thr Leu Ile Ser Ser Thr Asp Phe Leu Ser His Pro Phe
                 590                 595                 600

 Gly Ile Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Leu Glu
                 605                 610                 615

 Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Asn Gly Leu Glu Ile
                 620                 625                 630

 Ser Ile Leu Ala Glu Asn Leu Asn Asn Pro His Asp Ile Val Ile
                 635                 640                 645

 Phe His Glu Leu Lys Gln Pro Arg Ala Pro Asp Ala Cys Glu Leu
                 650                 655                 660

 Ser Val Gln Pro Asn Gly Gly Cys Glu Tyr Leu Cys Leu Pro Ala
                 665                 670                 675

 Pro Gln Ile Ser Ser His Ser Pro Lys Tyr Thr Cys Ala Cys Pro
                 680                 685                 690

 Asp Thr Met Trp Leu Gly Pro Asp Met Lys Arg Cys Tyr Arg Ala
                 695                 700                 705

 Pro Gln Ser Thr Ser Thr Thr Thr Leu Ala Ser Thr Met Thr Arg
                 710                 715                 720

 Thr Val Pro Ala Thr Thr Arg Ala Pro Gly Thr Thr Val His Arg
                 725                 730                 735

 Ser Thr Tyr Gln Asn His Ser Thr Glu Thr Pro Ser Leu Thr Ala
                 740                 745                 750

 Ala Val Pro Ser Ser Val Ser Val Pro Arg Ala Pro Ser Ile Ser
                 755                 760                 765

 Pro Ser Thr Leu Ser Pro Ala Thr Ser Asn His Ser Gln His Tyr
                 770                 775                 780

 Ala Asn Glu Asp Ser Lys Met Gly Ser Thr Val Thr Ala Ala Val
                 785                 790                 795

 Ile Gly Ile Ile Val Pro Ile Val Val Ile Ala Leu Leu Cys Met
                 800                 805                 810

 Ser Gly Tyr Leu Ile Trp Arg Asn Trp Lys Arg Lys Asn Thr Lys
                 815                 820                 825

 Ser Met Asn Phe Asp Asn Pro Val Tyr Arg Lys Thr Thr Glu Glu
                 830                 835                 840

 Glu Asp Glu Asp Glu Leu His Ile Gly Arg Thr Ala Gln Ile Gly
                 845                 850                 855

 His Val Tyr Pro Ala Ala Ile Ser Ser Phe Asp Arg Pro Leu Trp
                 860                 865                 870

 Ala Glu Pro Cys Leu Gly Glu Thr Arg Glu Pro Glu Asp Pro Ala
                 875                 880                 885

 Pro Ala Leu Lys Glu Leu Phe Val Leu Pro Gly Glu Pro Arg Ser
                 890                 895                 900

 Gln Leu His Gln Leu Pro Lys Asn Pro Leu Ser Glu Leu Pro Val
                 905                 910                 915

 Val Lys Ser Lys Arg Val Ala Leu Ser Leu Glu Asp Asp Gly Leu
                 920                 925                 930

 Pro
    

<210> 3
<211> 3460
<212> PRT
<213> Homo sapiens

<400> 3
 Met Glu Arg Ser Gly Trp Ala Arg Gln Thr Phe Leu Leu Ala Leu
   1               5                  10                  15

 Leu Leu Gly Ala Thr Leu Arg Ala Arg Ala Ala Ala Gly Tyr Tyr
                  20                  25                  30

 Pro Arg Phe Ser Pro Phe Phe Phe Leu Cys Thr His His Gly Glu
                  35                  40                  45

 Leu Glu Gly Asp Gly Glu Gln Gly Glu Val Leu Ile Ser Leu His
                  50                  55                  60

 Ile Ala Gly Asn Pro Thr Tyr Tyr Val Pro Gly Gln Glu Tyr His
                  65                  70                  75

 Val Thr Ile Ser Thr Ser Thr Phe Phe Asp Gly Leu Leu Val Thr
                  80                  85                  90

 Gly Leu Tyr Thr Ser Thr Ser Val Gln Ala Ser Gln Ser Ile Gly
                  95                 100                 105

 Gly Ser Ser Ala Phe Gly Phe Gly Ile Met Ser Asp His Gln Phe
                 110                 115                 120

 Gly Asn Gln Phe Met Cys Ser Val Val Ala Ser His Val Ser His
                 125                 130                 135

 Leu Pro Thr Thr Asn Leu Ser Phe Ile Trp Ile Ala Pro Pro Ala
                 140                 145                 150

 Gly Thr Gly Cys Val Asn Phe Met Ala Thr Ala Thr His Arg Gly
                 155                 160                 165

 Gln Val Ile Phe Lys Asp Ala Leu Ala Gln Gln Leu Cys Glu Gln
                 170                 175                 180

 Gly Ala Pro Thr Asp Val Thr Val His Pro His Leu Ala Glu Ile
                 185                 190                 195

 His Ser Asp Ser Ile Ile Leu Arg Asp Asp Phe Asp Ser Tyr His
                 200                 205                 210

 Gln Leu Gln Leu Asn Pro Asn Ile Trp Val Glu Cys Asn Asn Cys
                 215                 220                 225

 Glu Thr Gly Glu Gln Cys Gly Ala Ile Met His Gly Asn Ala Val
                 230                 235                 240

 Thr Phe Cys Glu Pro Tyr Gly Pro Arg Glu Leu Ile Thr Thr Gly
                 245                 250                 255

 Leu Asn Thr Thr Thr Ala Ser Val Leu Gln Phe Ser Ile Gly Ser
                 260                 265                 270

 Gly Ser Cys Arg Phe Ser Tyr Ser Asp Pro Ser Ile Ile Val Leu
                 275                 280                 285

 Tyr Ala Lys Asn Asn Ser Ala Asp Trp Ile Gln Leu Glu Lys Ile
                 290                 295                 300

 Arg Ala Pro Ser Asn Val Ser Thr Ile Ile His Ile Leu Tyr Leu
                 305                 310                 315

 Pro Glu Asp Ala Lys Gly Glu Asn Val Gln Phe Gln Trp Lys Gln
                 320                 325                 330

 Glu Asn Leu Arg Val Gly Glu Val Tyr Glu Ala Cys Trp Ala Leu
                 335                 340                 345

 Asp Asn Ile Leu Ile Ile Asn Ser Ala His Arg Gln Val Val Leu
                 350                 355                 360

 Glu Asp Ser Leu Asp Pro Val Asp Thr Gly Asn Trp Leu Phe Phe
                 365                 370                 375

 Pro Gly Ala Thr Val Lys His Ser Cys Gln Ser Asp Gly Asn Ser
                 380                 385                 390

 Ile Tyr Phe His Gly Asn Glu Gly Ser Glu Phe Asn Phe Ala Thr
                 395                 400                 405

 Thr Arg Asp Val Asp Leu Ser Thr Glu Asp Ile Gln Glu Gln Trp
                 410                 415                 420

 Ser Glu Glu Phe Glu Ser Gln Pro Thr Gly Trp Asp Val Leu Gly
                 425                 430                 435

 Ala Val Ile Gly Thr Glu Cys Gly Thr Ile Glu Ser Gly Leu Ser
                 440                 445                 450

 Met Val Phe Leu Lys Asp Gly Glu Arg Lys Leu Cys Thr Pro Ser
                 455                 460                 465

 Met Asp Thr Thr Gly Tyr Gly Asn Leu Arg Phe Tyr Phe Val Met
                 470                 475                 480

 Gly Gly Ile Cys Asp Pro Gly Asn Ser His Glu Asn Asp Ile Ile
                 485                 490                 495

 Leu Tyr Ala Lys Ile Glu Gly Arg Lys Glu His Ile Thr Leu Asp
                 500                 505                 510

 Thr Leu Ser Tyr Ser Ser Tyr Lys Val Pro Ser Leu Val Ser Val
                 515                 520                 525

 Val Ile Asn Pro Glu Leu Gln Thr Pro Ala Thr Lys Phe Cys Leu
                 530                 535                 540

 Arg Gln Lys Asn His Gln Gly His Asn Arg Asn Val Trp Ala Val
                 545                 550                 555

 Asp Phe Phe His Val Leu Pro Val Leu Pro Ser Thr Met Ser His
                 560                 565                 570

 Met Ile Gln Phe Ser Ile Asn Leu Gly Cys Gly Thr His Gln Pro
                 575                 580                 585

 Gly Asn Ser Val Ser Leu Glu Phe Ser Thr Asn His Gly Arg Ser
                 590                 595                 600

 Trp Ser Leu Leu His Thr Glu Cys Leu Pro Glu Ile Cys Ala Gly
                 605                 610                 615

 Pro His Leu Pro His Ser Thr Val Tyr Ser Ser Glu Asn Tyr Ser
                 620                 625                 630

 Gly Trp Asn Arg Ile Thr Ile Pro Leu Pro Asn Ala Ala Leu Thr
                 635                 640                 645

 Arg Asn Thr Arg Ile Arg Trp Arg Gln Thr Gly Pro Ile Leu Gly
                 650                 655                 660

 Asn Met Trp Ala Ile Asp Asn Val Tyr Ile Gly Pro Ser Cys Leu
                 665                 670                 675

 Lys Phe Cys Ser Gly Arg Gly Gln Cys Thr Arg His Gly Cys Lys
                 680                 685                 690

 Cys Asp Pro Gly Phe Ser Gly Pro Ala Cys Glu Met Ala Ser Gln
                 695                 700                 705

 Thr Phe Pro Met Phe Ile Ser Glu Ser Phe Gly Ser Ser Arg Leu
                 710                 715                 720

 Ser Ser Tyr His Asn Phe Tyr Ser Ile Arg Gly Ala Glu Val Ser
                 725                 730                 735

 Phe Gly Cys Gly Val Leu Ala Ser Gly Lys Ala Leu Val Phe Asn
                 740                 745                 750

 Lys Glu Gly Arg Arg Gln Leu Ile Thr Ser Phe Leu Asp Ser Ser
                 755                 760                 765

 Gln Ser Arg Phe Leu Gln Phe Thr Leu Arg Leu Gly Ser Lys Ser
                 770                 775                 780

 Val Leu Ser Thr Cys Arg Ala Pro Asp Gln Pro Gly Glu Gly Val
                 785                 790                 795

 Leu Leu His Tyr Ser Tyr Asp Asn Gly Ile Thr Trp Lys Leu Leu
                 800                 805                 810

 Glu His Tyr Ser Tyr Leu Ser Tyr His Glu Pro Arg Ile Ile Ser
                 815                 820                 825

 Val Glu Leu Pro Gly Asp Ala Lys Gln Phe Gly Ile Gln Phe Arg
                 830                 835                 840

 Trp Trp Gln Pro Tyr His Ser Ser Gln Arg Glu Asp Val Trp Ala
                 845                 850                 855

 Ile Asp Glu Ile Ile Met Thr Ser Val Leu Phe Asn Ser Ile Ser
                 860                 865                 870

 Leu Asp Phe Thr Asn Leu Val Glu Val Thr Gln Ser Leu Gly Phe
                 875                 880                 885

 Tyr Leu Gly Asn Val Gln Pro Tyr Cys Gly His Asp Trp Thr Leu
                 890                 895                 900

 Cys Phe Thr Gly Asp Ser Lys Leu Ala Ser Ser Met Arg Tyr Val
                 905                 910                 915

 Glu Thr Gln Ser Met Gln Ile Gly Ala Ser Tyr Met Ile Gln Phe
                 920                 925                 930

 Ser Leu Val Met Gly Cys Gly Gln Lys Tyr Thr Pro His Met Asp
                 935                 940                 945

 Asn Gln Val Lys Leu Glu Tyr Ser Thr Asn His Gly Leu Thr Trp
                 950                 955                 960

 His Leu Val Gln Glu Glu Cys Leu Pro Ser Met Pro Ser Cys Gln
                 965                 970                 975

 Glu Phe Thr Ser Ala Ser Ile Tyr His Ala Ser Glu Phe Thr Gln
                 980                 985                 990

 Trp Arg Arg Val Ile Val Leu Leu Pro Gln Lys Thr Trp Ser Ser
                 995                1000                1005

 Ala Thr Arg Phe Arg Trp Ser Gln Ser Tyr Tyr Thr Ala Gln Asp
                1010                1015                1020

 Glu Trp Ala Leu Asp Ser Ile Tyr Ile Gly Gln Gln Cys Pro Asn
                1025                1030                1035

 Met Cys Ser Gly His Gly Ser Cys Asp His Gly Ile Cys Arg Cys
                1040                1045                1050

 Asp Gln Gly Tyr Gln Gly Thr Glu Cys His Pro Glu Ala Ala Leu
                1055                1060                1065

 Pro Ser Thr Ile Met Ser Asp Phe Glu Asn Gln Asn Gly Trp Glu
                1070                1075                1080

 Ser Asp Trp Gln Glu Val Ile Gly Gly Glu Ile Val Lys Pro Glu
                1085                1090                1095

 Gln Gly Cys Gly Val Ile Ser Ser Gly Ser Ser Leu Tyr Phe Ser
                1100                1105                1110

 Lys Ala Gly Lys Arg Gln Leu Val Ser Trp Asp Leu Asp Thr Ser
                1115                1120                1125

 Trp Val Asp Phe Val Gln Phe Tyr Ile Gln Ile Gly Gly Glu Ser
                1130                1135                1140

 Ala Ser Cys Asn Lys Pro Asp Ser Arg Glu Glu Gly Val Leu Leu
                1145                1150                1155

 Gln Tyr Ser Asn Asn Gly Gly Ile Gln Trp His Leu Leu Ala Glu
                1160                1165                1170

 Met Tyr Phe Ser Asp Phe Ser Lys Pro Arg Phe Val Tyr Leu Glu
                1175                1180                1185

 Leu Pro Ala Ala Ala Lys Thr Pro Cys Thr Arg Phe Arg Trp Trp
                1190                1195                1200

 Gln Pro Val Phe Ser Gly Glu Asp Tyr Asp Gln Trp Ala Val Asp
                1205                1210                1215

 Asp Ile Ile Ile Leu Ser Glu Lys Gln Lys Gln Ile Ile Pro Val
                1220                1225                1230

 Ile Asn Pro Thr Leu Pro Gln Asn Phe Tyr Glu Lys Pro Ala Phe
                1235                1240                1245

 Asp Tyr Pro Met Asn Gln Met Ser Val Trp Leu Met Leu Ala Asn
                1250                1255                1260

 Glu Gly Met Val Lys Asn Glu Thr Phe Cys Ala Ala Thr Pro Ser
                1265                1270                1275

 Ala Met Ile Phe Gly Lys Ser Asp Gly Asp Arg Phe Ala Val Thr
                1280                1285                1290

 Arg Asp Leu Thr Leu Lys Pro Gly Tyr Val Leu Gln Phe Lys Leu
                1295                1300                1305

 Asn Ile Gly Cys Ala Asn Gln Phe Ser Ser Thr Ala Pro Val Leu
                1310                1315                1320

 Leu Gln Tyr Ser His Asp Ala Gly Met Ser Trp Phe Leu Val Lys
                1325                1330                1335

 Glu Gly Cys Tyr Pro Ala Ser Ala Gly Lys Gly Cys Glu Gly Asn
                1340                1345                1350

 Ser Arg Glu Leu Ser Glu Pro Thr Met Tyr His Thr Gly Asp Phe
                1355                1360                1365

 Glu Glu Trp Thr Arg Ile Thr Ile Val Ile Pro Arg Ser Leu Ala
                1370                1375                1380

 Ser Ser Lys Thr Arg Phe Arg Trp Ile Gln Glu Ser Ser Ser Gln
                1385                1390                1395

 Lys Asn Val Pro Pro Phe Gly Leu Asp Gly Val Tyr Ile Ser Glu
                1400                1405                1410

 Pro Cys Pro Ser Tyr Cys Ser Gly His Gly Asp Cys Ile Ser Gly
                1415                1420                1425

 Val Cys Phe Cys Asp Leu Gly Tyr Thr Ala Ala Gln Gly Thr Cys
                1430                1435                1440

 Val Ser Asn Val Pro Asn His Asn Glu Met Phe Asp Arg Phe Glu
                1445                1450                1455

 Gly Lys Leu Ser Pro Leu Trp Tyr Lys Ile Thr Gly Ala Gln Val
                1460                1465                1470

 Gly Thr Gly Cys Gly Thr Leu Asn Asp Gly Lys Ser Leu Tyr Phe
                1475                1480                1485

 Asn Gly Pro Gly Lys Arg Glu Ala Arg Thr Val Pro Leu Asp Thr
                1490                1495                1500

 Arg Asn Ile Arg Leu Val Gln Phe Tyr Ile Gln Ile Gly Ser Lys
                1505                1510                1515

 Thr Ser Gly Ile Thr Cys Ile Lys Pro Arg Thr Arg Asn Glu Gly
                1520                1525                1530

 Leu Ile Val Gln Tyr Ser Asn Asp Asn Gly Ile Leu Trp His Leu
                1535                1540                1545

 Leu Arg Glu Leu Asp Phe Met Ser Phe Leu Glu Pro Gln Ile Ile
                1550                1555                1560

 Ser Ile Asp Leu Pro Gln Asp Ala Lys Thr Pro Ala Thr Ala Phe
                1565                1570                1575

 Arg Trp Trp Gln Pro Gln His Gly Lys His Ser Ala Gln Trp Ala
                1580                1585                1590

 Leu Asp Asp Val Leu Ile Gly Met Asn Asp Ser Ser Gln Thr Gly
                1595                1600                1605

 Phe Gln Asp Lys Phe Asp Gly Ser Ile Asp Leu Gln Ala Asn Trp
                1610                1615                1620

 Tyr Arg Ile Gln Gly Gly Gln Val Asp Ile Asp Cys Leu Ser Met
                1625                1630                1635

 Asp Thr Ala Leu Ile Phe Thr Glu Asn Ile Gly Lys Pro Arg Tyr
                1640                1645                1650

 Ala Glu Thr Trp Asp Phe His Val Ser Ala Ser Thr Phe Leu Gln
                1655                1660                1665

 Phe Glu Met Ser Met Gly Cys Ser Lys Pro Phe Ser Asn Ser His
                1670                1675                1680

 Ser Val Gln Leu Gln Tyr Ser Leu Asn Asn Gly Lys Asp Trp His
                1685                1690                1695

 Leu Val Thr Glu Glu Cys Val Pro Pro Thr Ile Gly Cys Leu His
                1700                1705                1710

 Tyr Thr Glu Ser Ser Ile Tyr Thr Ser Glu Arg Phe Gln Asn Trp
                1715                1720                1725

 Lys Arg Ile Thr Val Tyr Leu Pro Leu Ser Thr Ile Ser Pro Arg
                1730                1735                1740

 Thr Arg Phe Arg Trp Ile Gln Ala Asn Tyr Thr Val Gly Ala Asp
                1745                1750                1755

 Ser Trp Ala Ile Asp Asn Val Val Leu Ala Ser Gly Cys Pro Trp
                1760                1765                1770

 Met Cys Ser Gly Arg Gly Ile Cys Asp Ala Gly Arg Cys Val Cys
                1775                1780                1785

 Asp Arg Gly Phe Gly Gly Pro Tyr Cys Val Pro Val Val Pro Leu
                1790                1795                1800

 Pro Ser Ile Leu Lys Asp Asp Phe Asn Gly Asn Leu His Pro Asp
                1805                1810                1815

 Leu Trp Pro Glu Val Tyr Gly Ala Glu Arg Gly Asn Leu Asn Gly
                1820                1825                1830

 Glu Thr Ile Lys Ser Gly Thr Ser Leu Ile Phe Lys Gly Glu Gly
                1835                1840                1845

 Leu Arg Met Leu Ile Ser Arg Asp Leu Asp Cys Thr Asn Thr Met
                1850                1855                1860

 Tyr Val Gln Phe Ser Leu Arg Phe Ile Ala Lys Ser Thr Pro Glu
                1865                1870                1875

 Arg Ser His Ser Ile Leu Leu Gln Phe Ser Ile Ser Gly Gly Ile
                1880                1885                1890

 Thr Trp His Leu Met Asp Glu Phe Tyr Phe Pro Gln Thr Thr Asn
                1895                1900                1905

 Ile Leu Phe Ile Asn Val Pro Leu Pro Tyr Thr Ala Gln Thr Asn
                1910                1915                1920

 Ala Thr Arg Phe Arg Leu Trp Gln Pro Tyr Asn Asn Gly Lys Lys
                1925                1930                1935

 Glu Glu Ile Trp Ile Val Asp Asp Phe Ile Ile Asp Gly Asn Asn
                1940                1945                1950

 Val Asn Asn Pro Val Met Leu Leu Asp Thr Phe Asp Phe Gly Pro
                1955                1960                1965

 Arg Glu Asp Asn Trp Phe Phe Tyr Pro Gly Gly Asn Ile Gly Leu
                1970                1975                1980

 Tyr Cys Pro Tyr Ser Ser Lys Gly Ala Pro Glu Glu Asp Ser Ala
                1985                1990                1995

 Met Val Phe Val Ser Asn Glu Val Gly Glu His Ser Ile Thr Thr
                2000                2005                2010

 Arg Asp Leu Asn Val Asn Glu Asn Thr Ile Ile Gln Phe Glu Ile
                2015                2020                2025

 Asn Val Gly Cys Ser Thr Asp Ser Ser Ser Ala Asp Pro Val Arg
                2030                2035                2040

 Leu Glu Phe Ser Arg Asp Phe Gly Ala Thr Trp His Leu Leu Leu
                2045                2050                2055

 Pro Leu Cys Tyr His Ser Ser Ser His Val Ser Ser Leu Cys Ser
                2060                2065                2070

 Thr Glu His His Pro Ser Ser Thr Tyr Tyr Ala Gly Thr Met Gln
                2075                2080                2085

 Gly Trp Arg Arg Glu Val Val His Phe Gly Lys Leu His Leu Cys
                2090                2095                2100

 Gly Ser Val Arg Phe Arg Trp Tyr Gln Gly Phe Tyr Pro Ala Gly
                2105                2110                2115

 Ser Gln Pro Val Thr Trp Ala Ile Asp Asn Val Tyr Ile Gly Pro
                2120                2125                2130

 Gln Cys Glu Glu Met Cys Asn Gly Gln Gly Ser Cys Ile Asn Gly
                2135                2140                2145

 Thr Lys Cys Ile Cys Asp Pro Gly Tyr Ser Gly Pro Thr Cys Lys
                2150                2155                2160

 Ile Ser Thr Lys Asn Pro Asp Phe Leu Lys Asp Asp Phe Glu Gly
                2165                2170                2175

 Gln Leu Glu Ser Asp Arg Phe Leu Leu Met Ser Gly Gly Lys Pro
                2180                2185                2190

 Ser Arg Lys Cys Gly Ile Leu Ser Ser Gly Asn Asn Leu Phe Phe
                2195                2200                2205

 Asn Glu Asp Gly Leu Arg Met Leu Met Thr Arg Asp Leu Asp Leu
                2210                2215                2220

 Ser His Ala Arg Phe Val Gln Phe Phe Met Arg Leu Gly Cys Gly
                2225                2230                2235

 Lys Gly Val Pro Asp Pro Arg Ser Gln Pro Val Leu Leu Gln Tyr
                2240                2245                2250

 Ser Leu Asn Gly Gly Leu Ser Trp Ser Leu Leu Gln Glu Phe Leu
                2255                2260                2265

 Phe Ser Asn Ser Ser Asn Val Gly Arg Tyr Ile Ala Leu Glu Ile
                2270                2275                2280

 Pro Leu Lys Ala Arg Ser Gly Ser Thr Arg Leu Arg Trp Trp Gln
                2285                2290                2295

 Pro Ser Glu Asn Gly His Phe Tyr Ser Pro Trp Val Ile Asp Gln
                2300                2305                2310

 Ile Leu Ile Gly Gly Asn Ile Ser Gly Asn Thr Val Leu Glu Asp
                2315                2320                2325

 Asp Phe Thr Thr Leu Asp Ser Arg Lys Trp Leu Leu His Pro Gly
                2330                2335                2340

 Gly Thr Lys Met Pro Val Cys Gly Ser Thr Gly Asp Ala Leu Val
                2345                2350                2355

 Phe Ile Glu Lys Ala Ser Thr Arg Tyr Val Val Ser Thr Asp Val
                2360                2365                2370

 Ala Val Asn Glu Asp Ser Phe Leu Gln Ile Asp Phe Ala Ala Ser
                2375                2380                2385

 Cys Ser Val Thr Asp Ser Cys Tyr Ala Ile Glu Leu Glu Tyr Ser
                2390                2395                2400

 Val Asp Leu Gly Leu Ser Trp His Pro Leu Val Arg Asp Cys Leu
                2405                2410                2415

 Pro Thr Asn Val Glu Cys Ser Arg Tyr His Leu Gln Arg Ile Leu
                2420                2425                2430

 Val Ser Asp Thr Phe Asn Lys Trp Thr Arg Ile Thr Leu Pro Leu
                2435                2440                2445

 Pro Pro Tyr Thr Arg Ser Gln Ala Thr Arg Phe Arg Trp His Gln
                2450                2455                2460

 Pro Ala Pro Phe Asp Lys Gln Gln Thr Trp Ala Ile Asp Asn Val
                2465                2470                2475

 Tyr Ile Gly Asp Gly Cys Ile Asp Met Cys Ser Gly His Gly Arg
                2480                2485                2490

 Cys Ile Gln Gly Asn Cys Val Cys Asp Glu Gln Trp Gly Gly Leu
                2495                2500                2505

 Tyr Cys Asp Asp Pro Glu Thr Ser Leu Pro Thr Gln Leu Lys Asp
                2510                2515                2520

 Asn Phe Asn Arg Ala Pro Ser Ser Gln Asn Trp Leu Thr Val Asn
                2525                2530                2535

 Gly Gly Lys Leu Ser Thr Val Cys Gly Ala Val Ala Ser Gly Met
                2540                2545                2550

 Ala Leu His Phe Ser Gly Gly Cys Ser Arg Leu Leu Val Thr Val
                2555                2560                2565

 Asp Leu Asn Leu Thr Asn Ala Glu Phe Ile Gln Phe Tyr Phe Met
                2570                2575                2580

 Tyr Gly Cys Leu Ile Thr Pro Asn Asn Arg Asn Gln Gly Val Leu
                2585                2590                2595

 Leu Glu Tyr Ser Val Asn Gly Gly Ile Thr Trp Asn Leu Leu Met
                2600                2605                2610

 Glu Ile Phe Tyr Asp Gln Tyr Ser Lys Pro Gly Phe Val Asn Ile
                2615                2620                2625

 Leu Leu Pro Pro Asp Ala Lys Glu Ile Ala Thr Arg Phe Arg Trp
                2630                2635                2640

 Trp Gln Pro Arg His Asp Gly Leu Asp Gln Asn Asp Trp Ala Ile
                2645                2650                2655

 Asp Asn Val Leu Ile Ser Gly Ser Ala Asp Gln Arg Thr Val Met
                2660                2665                2670

 Leu Asp Thr Phe Ser Ser Ala Pro Val Pro Gln His Glu Arg Ser
                2675                2680                2685

 Pro Ala Asp Ala Gly Pro Val Gly Arg Ile Ala Phe Asp Met Phe
                2690                2695                2700

 Met Glu Asp Lys Thr Ser Val Asn Glu His Trp Leu Phe His Asp
                2705                2710                2715

 Asp Cys Thr Val Glu Arg Phe Cys Asp Ser Pro Asp Gly Val Met
                2720                2725                2730

 Leu Cys Gly Ser His Asp Gly Arg Glu Val Tyr Ala Val Thr His
                2735                2740                2745

 Asp Leu Thr Pro Thr Glu Gly Trp Ile Met Gln Phe Lys Ile Ser
                2750                2755                2760

 Val Gly Cys Lys Val Ser Glu Lys Ile Ala Gln Asn Gln Ile His
                2765                2770                2775

 Val Gln Tyr Ser Thr Asp Phe Gly Val Ser Trp Asn Tyr Leu Val
                2780                2785                2790

 Pro Gln Cys Leu Pro Ala Asp Pro Lys Cys Ser Gly Ser Val Ser
                2795                2800                2805

 Gln Pro Ser Val Phe Phe Pro Thr Lys Gly Trp Lys Arg Ile Thr
                2810                2815                2820

 Tyr Pro Leu Pro Glu Ser Leu Val Gly Asn Pro Val Arg Phe Arg
                2825                2830                2835

 Phe Tyr Gln Lys Tyr Ser Asp Met Gln Trp Ala Ile Asp Asn Phe
                2840                2845                2850

 Tyr Leu Gly Pro Gly Cys Leu Asp Asn Cys Arg Gly His Gly Asp
                2855                2860                2865

 Cys Leu Arg Glu Gln Cys Ile Cys Asp Pro Gly Tyr Ser Gly Pro
                2870                2875                2880

 Asn Cys Tyr Leu Thr His Thr Leu Lys Thr Phe Leu Lys Glu Arg
                2885                2890                2895

 Phe Asp Ser Glu Glu Ile Lys Pro Asp Leu Trp Met Ser Leu Glu
                2900                2905                2910

 Gly Gly Ser Thr Cys Thr Glu Cys Gly Ile Leu Ala Glu Asp Thr
                2915                2920                2925

 Ala Leu Tyr Phe Gly Gly Ser Thr Val Arg Gln Ala Val Thr Gln
                2930                2935                2940

 Asp Leu Asp Leu Arg Gly Ala Lys Phe Leu Gln Tyr Trp Gly Arg
                2945                2950                2955

 Ile Gly Ser Glu Asn Asn Met Thr Ser Cys His Arg Pro Ile Cys
                2960                2965                2970

 Arg Lys Glu Gly Val Leu Leu Asp Tyr Ser Thr Asp Gly Gly Ile
                2975                2980                2985

 Thr Trp Thr Leu Leu His Glu Met Asp Tyr Gln Lys Tyr Ile Ser
                2990                2995                3000

 Val Arg His Asp Tyr Ile Leu Leu Pro Glu Asp Ala Leu Thr Asn
                3005                3010                3015

 Thr Thr Arg Leu Arg Trp Trp Gln Pro Phe Val Ile Ser Asn Gly
                3020                3025                3030

 Ile Val Val Ser Gly Val Glu Arg Ala Gln Trp Ala Leu Asp Asn
                3035                3040                3045

 Ile Leu Ile Gly Gly Ala Glu Ile Asn Pro Ser Gln Leu Val Asp
                3050                3055                3060

 Thr Phe Asp Asp Glu Gly Thr Ser His Glu Glu Asn Trp Ser Phe
                3065                3070                3075

 Tyr Pro Asn Ala Val Arg Thr Ala Gly Phe Cys Gly Asn Pro Ser
                3080                3085                3090

 Phe His Leu Tyr Trp Pro Asn Lys Lys Lys Asp Lys Thr His Asn
                3095                3100                3105

 Ala Leu Ser Ser Arg Glu Leu Ile Ile Gln Pro Gly Tyr Met Met
                3110                3115                3120

 Gln Phe Lys Ile Val Val Gly Cys Glu Ala Thr Ser Cys Gly Asp
                3125                3130                3135

 Leu His Ser Val Met Leu Glu Tyr Thr Lys Asp Ala Arg Ser Asp
                3140                3145                3150

 Ser Trp Gln Leu Val Gln Thr Gln Cys Leu Pro Ser Ser Ser Asn
                3155                3160                3165

 Ser Ile Gly Cys Ser Pro Phe Gln Phe His Glu Ala Thr Ile Tyr
                3170                3175                3180

 Asn Ser Val Asn Ser Ser Ser Trp Lys Arg Ile Thr Ile Gln Leu
                3185                3190                3195

 Pro Asp His Val Ser Ser Ser Ala Thr Gln Phe Arg Trp Ile Gln
                3200                3205                3210

 Lys Gly Glu Glu Thr Glu Lys Gln Ser Trp Ala Ile Asp His Val
                3215                3220                3225

 Tyr Ile Gly Glu Ala Cys Pro Lys Leu Cys Ser Gly His Gly Tyr
                3230                3235                3240

 Cys Thr Thr Gly Ala Ile Cys Ile Cys Asp Glu Ser Phe Gln Gly
                3245                3250                3255

 Asp Asp Cys Ser Val Phe Ser His Asp Leu Pro Ser Tyr Ile Lys
                3260                3265                3270

 Asp Asn Phe Glu Ser Ala Arg Val Thr Glu Ala Asn Trp Glu Thr
                3275                3280                3285

 Ile Gln Gly Gly Val Ile Gly Ser Gly Cys Gly Gln Leu Ala Pro
                3290                3295                3300

 Tyr Ala His Gly Asp Ser Leu Tyr Phe Asn Gly Cys Gln Ile Arg
                3305                3310                3315

 Gln Ala Ala Thr Lys Pro Leu Asp Leu Thr Arg Ala Ser Lys Ile
                3320                3325                3330

 Met Phe Val Leu Gln Ile Gly Ser Met Ser Gln Thr Asp Ser Cys
                3335                3340                3345

 Asn Ser Asp Leu Ser Gly Pro His Ala Val Asp Lys Ala Val Leu
                3350                3355                3360

 Leu Gln Tyr Ser Val Asn Asn Gly Ile Thr Trp His Val Ile Ala
                3365                3370                3375

 Gln His Gln Pro Lys Asp Phe Thr Gln Ala Gln Arg Val Ser Tyr
                3380                3385                3390

 Asn Val Pro Leu Glu Ala Arg Met Lys Gly Val Leu Leu Arg Trp
                3395                3400                3405

 Trp Gln Pro Arg His Asn Gly Thr Gly His Asp Gln Trp Ala Leu
                3410                3415                3420

 Asp His Val Glu Val Val Leu Val Ser Thr Arg Lys Gln Asn Tyr
                3425                3430                3435

 Met Met Asn Phe Ser Arg Gln His Gly Leu Arg His Phe Tyr Asn
                3440                3445                3450

 Arg Arg Arg Arg Ser Leu Arg Arg Tyr Pro
                3455                3460

<210> 4
<211> 381
<212> PRT
<213> Homo sapiens

<220>
<221> Unsure
<222> 59,300,318,330,345,352,367,369,376,378
<223> Unknown amino acid

<400> 4
 Met Trp Arg Ser Leu Gly Leu Ala Leu Ala Leu Cys Leu Leu Pro
   1               5                  10                  15

 Ser Gly Gly Thr Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln
                  20                  25                  30

 Pro Pro Ala Trp Ser Ile Arg Asp Gln Asp Pro Met Leu Asn Ser
                  35                  40                  45

 Asn Gly Ser Val Thr Val Val Ala Leu Leu Gln Ala Ser Xaa Tyr
                  50                  55                  60

 Leu Cys Ile Ile Glu Ala Ser Lys Leu Glu Asp Leu Arg Val Lys
                  65                  70                  75

 Leu Lys Lys Glu Gly Tyr Ser Asn Ile Ser Tyr Ile Val Val Asn
                  80                  85                  90

 His Gln Gly Ile Ser Ser Arg Leu Lys Tyr Thr His Leu Lys Asn
                  95                 100                 105

 Lys Val Ser Glu His Ile Pro Val Tyr Gln Gln Glu Glu Asn Gln
                 110                 115                 120

 Thr Asp Val Trp Thr Leu Leu Asn Gly Ser Lys Asp Asp Phe Leu
                 125                 130                 135

 Ile Tyr Asp Arg Cys Gly Arg Leu Val Tyr His Leu Gly Leu Pro
                 140                 145                 150

 Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu Glu Ala Ile Lys Ile
                 155                 160                 165

 Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser Leu Thr Thr Leu
                 170                 175                 180

 Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala Thr Val Asp
                 185                 190                 195

 Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu His His
                 200                 205                 210

 His Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser Glu
                 215                 220                 225

 Asn Gln Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro
                 230                 235                 240

 Pro Gly Leu His His His His Lys His Lys Gly Gln His Arg Gln
                 245                 250                 255

 Gly His Pro Glu Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln
                 260                 265                 270

 Asp Leu Gln Lys Lys Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu
                 275                 280                 285

 Leu Cys Lys Leu Pro Thr Asp Ser Glu Leu Ala Pro Arg Ser Xaa
                 290                 295                 300

 Cys Cys His Cys Arg His Leu Ile Phe Glu Lys Thr Gly Ser Ala
                 305                 310                 315

 Ile Thr Xaa Gln Cys Lys Glu Asn Leu Pro Ser Leu Cys Ser Xaa
                 320                 325                 330

 Gln Gly Leu Arg Ala Glu Glu Asn Ile Thr Glu Ser Cys Gln Xaa
                 335                 340                 345

 Arg Leu Pro Pro Ala Ala Xaa Gln Ile Ser Gln Gln Leu Ile Pro
                 350                 355                 360

 Thr Glu Ala Ser Ala Ser Xaa Arg Xaa Lys Asn Gln Ala Lys Lys
                 365                 370                 375

 Xaa Glu Xaa Pro Ser Asn
                 380    

