
                               SEQUENCE LISTING

<110> ABBOTT BIOTECHNOLOGY, LTD., et al.

<120> METHODS AND COMPOSITIONS FOR PREDICTING RESPONSIVENESS
      TO TREATMENT WITH TNF-ALPHA INHIBITOR  

<130> 117813-10120

<140> NEW APPLICATION
<141> CONCURRENTLY HEREWITH

<150> 61/434,296 
<151> 2011-01-19

<150> 61/409,461
<151> 2010-11-02

<150> 61/359,009
<151> 2010-06-28

<150> 61/353,595
<151> 2010-06-10

<150> 61/300,807
<151> 2010-02-02

<160> 42

<170> PatentIn version 3.5

<210> 1
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: D2E7 light chain 
      variable region"

<400> 1
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 2
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: D2E7 heavy chain 
      variable region"

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: D2E7 light chain 
      variable region CDR3"


<220>
<221> VARIANT        
<222> (9)..(9)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (9)..(9)
<223> /note="Residue given in the sequence has no preference 
      with respect to the annotation for said position"

<400> 3
Gln Arg Tyr Asn Arg Ala Pro Tyr Thr
1               5                  


<210> 4
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: D2E7 heavy chain  
      variable region CDR3"


<220>
<221> VARIANT        
<222> (12)..(12)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (12)..(12)
<223> /note="Residue given in the sequence has no preference 
      with respect to the annotation for said position"

<400> 4
Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr
1               5                   10          


<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: D2E7 light chain  
      variable region CDR2"

<400> 5
Ala Ala Ser Thr Leu Gln Ser
1               5          


<210> 6
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: D2E7 heavy chain  
      variable region CDR2"

<400> 6
Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu
1               5                   10                  15      


Gly
    


<210> 7
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: D2E7 light chain 
      variable region CDR1"

<400> 7
Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala
1               5                   10      


<210> 8
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: D2E7 heavy chain  
      variable region CDR1"

<400> 8
Asp Tyr Ala Met His
1               5  


<210> 9
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 2SD4 light chain  
      variable region"

<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Tyr
                85                  90                  95      


Ala Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 10
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 2SD4 heavy chain  
      variable region"

<400> 10
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val
    50                  55                  60                  


Glu Gly Arg Phe Ala Val Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      


Thr Lys Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp Asn Trp Gly
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 11
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 2SD4 light chain  
      variable region CDR3"

<400> 11
Gln Lys Tyr Asn Ser Ala Pro Tyr Ala
1               5                  


<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: EP B12 light chain  
      variable region CDR3"

<400> 12
Gln Lys Tyr Asn Arg Ala Pro Tyr Ala
1               5                  


<210> 13
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VL10E4 light chain  
      variable region CDR3"

<400> 13
Gln Lys Tyr Gln Arg Ala Pro Tyr Thr
1               5                  



<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VL100A9 light chain  
      variable region CDR3"

<400> 14
Gln Lys Tyr Ser Ser Ala Pro Tyr Thr
1               5                  


<210> 15
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VLL100D2 light chain  
      variable region CDR3"

<400> 15
Gln Lys Tyr Asn Ser Ala Pro Tyr Thr
1               5                  


<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VLL0F4 light chain  
      variable region CDR3"

<400> 16
Gln Lys Tyr Asn Arg Ala Pro Tyr Thr
1               5                  


<210> 17
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: LOE5 light chain  
      variable region CDR3"

<400> 17
Gln Lys Tyr Asn Ser Ala Pro Tyr Tyr
1               5                  


<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VLLOG7 light chain  
      variable region CDR3"

<400> 18
Gln Lys Tyr Asn Ser Ala Pro Tyr Asn
1               5                  


<210> 19
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VLLOG9 light chain  
      variable region CDR3"

<400> 19
Gln Lys Tyr Thr Ser Ala Pro Tyr Thr
1               5                  


<210> 20
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VLLOH1 light chain  
      variable region CDR3"

<400> 20
Gln Lys Tyr Asn Arg Ala Pro Tyr Asn
1               5                  


<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VLLOH10 light chain  
      variable region CDR3"

<400> 21
Gln Lys Tyr Asn Ser Ala Ala Tyr Ser
1               5                  


<210> 22
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VL1B7 light chain  
      variable region CDR3"

<400> 22
Gln Gln Tyr Asn Ser Ala Pro Asp Thr
1               5                  


<210> 23
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VL1C1 light chain  
      variable region CDR3"

<400> 23
Gln Lys Tyr Asn Ser Asp Pro Tyr Thr
1               5                  


<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VL0.1F4 light chain  
      variable region CDR3"

<400> 24
Gln Lys Tyr Ile Ser Ala Pro Tyr Thr
1               5                  


<210> 25
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VL0.1H8 light chain  
      variable region CDR3"

<400> 25
Gln Lys Tyr Asn Arg Pro Pro Tyr Thr
1               5                  


<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: LOE7.A light chain  
      variable region CDR3"

<400> 26
Gln Arg Tyr Asn Arg Ala Pro Tyr Ala
1               5                  


<210> 27
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 2SD4 heavy chain  
      variable region CDR3"

<400> 27
Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp Asn
1               5                   10          


<210> 28
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VH1B11 heavy chain  
      variable region CDR3"

<400> 28
Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp Lys
1               5                   10          


<210> 29
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VH1D8 heavy chain  
      variable region CDR3"

<400> 29
Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp Tyr
1               5                   10          


<210> 30
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VH1A11 heavy chain  
      variable region CDR3"

<400> 30
Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp Asp
1               5                   10          



<210> 31
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VH1B12 heavy chain  
      variable region CDR3"

<400> 31
Ala Ser Tyr Leu Ser Thr Ser Phe Ser Leu Asp Tyr
1               5                   10          


<210> 32
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VH1E4 heavy chain  
      variable region CDR3"

<400> 32
Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu His Tyr
1               5                   10          


<210> 33
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VH1F6 heavy chain  
      variable region CDR3"

<400> 33
Ala Ser Phe Leu Ser Thr Ser Ser Ser Leu Glu Tyr
1               5                   10          


<210> 34
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 3C-H2 heavy chain  
      variable region CDR3"

<400> 34
Ala Ser Tyr Leu Ser Thr Ala Ser Ser Leu Glu Tyr
1               5                   10          
 

<210> 35
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: VH1-D2.N heavy chain  
      variable region CDR3"

<400> 35
Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Asn
1               5                   10          


<210> 36
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: D2E7 light chain  
      variable region"

<400> 36
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtagggga cagagtcacc       60

atcacttgtc gggcaagtca gggcatcaga aattacttag cctggtatca gcaaaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctacagcct      240

gaagatgttg caacttatta ctgtcaaagg tataaccgtg caccgtatac ttttggccag      300

gggaccaagg tggaaatcaa a                                                321


<210> 37
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: D2E7 heavy chain  
      variable region"

<400> 37
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ccggcaggtc cctgagactc       60

tcctgtgcgg cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggaatg ggtctcagct atcacttgga atagtggtca catagactat      180

gcggactctg tggagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggat acggccgtat attactgtgc gaaagtctcg      300

taccttagca ccgcgtcctc ccttgactat tggggccaag gtaccctggt caccgtctcg      360

agt                                                                    363


<210> 38
<211> 800
<212> PRT
<213> Homo sapiens

<400> 38
Met Lys Val Leu Gln Glu Pro Thr Cys Val Ser Asp Tyr Met Ser Ile 
1               5                   10                  15      


Ser Thr Cys Glu Trp Lys Met Asn Gly Pro Thr Asn Cys Ser Thr Glu 
            20                  25                  30          


Leu Arg Leu Leu Tyr Gln Leu Val Phe Leu Leu Ser Glu Ala His Thr 
        35                  40                  45              


Cys Ile Pro Glu Asn Asn Gly Gly Ala Gly Cys Val Cys His Leu Leu 
    50                  55                  60                  


Met Asp Asp Val Val Ser Ala Asp Asn Tyr Thr Leu Asp Leu Trp Ala 
65                  70                  75                  80  


Gly Gln Gln Leu Leu Trp Lys Gly Ser Phe Lys Pro Ser Glu His Val 
                85                  90                  95      


Lys Pro Arg Ala Pro Gly Asn Leu Thr Val His Thr Asn Val Ser Asp 
            100                 105                 110         


Thr Leu Leu Leu Thr Trp Ser Asn Pro Tyr Pro Pro Asp Asn Tyr Leu 
        115                 120                 125             


Tyr Asn His Leu Thr Tyr Ala Val Asn Ile Trp Ser Glu Asn Asp Pro 
    130                 135                 140                 


Ala Asp Phe Arg Ile Tyr Asn Val Thr Tyr Leu Glu Pro Ser Leu Arg 
145                 150                 155                 160 


Ile Ala Ala Ser Thr Leu Lys Ser Gly Ile Ser Tyr Arg Ala Arg Val 
                165                 170                 175     


Arg Ala Trp Ala Gln Cys Tyr Asn Thr Thr Trp Ser Glu Trp Ser Pro 
            180                 185                 190         


Ser Thr Lys Trp His Asn Ser Tyr Arg Glu Pro Phe Glu Gln His Leu 
        195                 200                 205             


Leu Leu Gly Val Ser Val Ser Cys Ile Val Ile Leu Ala Val Cys Leu 
    210                 215                 220                 


Leu Cys Tyr Val Ser Ile Thr Lys Ile Lys Lys Glu Trp Trp Asp Gln 
225                 230                 235                 240 


Ile Pro Asn Pro Ala Arg Ser Arg Leu Val Ala Ile Ile Ile Gln Asp 
                245                 250                 255     


Ala Gln Gly Ser Gln Trp Glu Lys Arg Ser Arg Gly Gln Glu Pro Ala 
            260                 265                 270         


Lys Cys Pro His Trp Lys Asn Cys Leu Thr Lys Leu Leu Pro Cys Phe 
        275                 280                 285             


Leu Glu His Asn Met Lys Arg Asp Glu Asp Pro His Lys Ala Ala Lys 
    290                 295                 300                 


Glu Met Pro Phe Gln Gly Ser Gly Lys Ser Ala Trp Cys Pro Val Glu 
305                 310                 315                 320 


Ile Ser Lys Thr Val Leu Trp Pro Glu Ser Ile Ser Val Val Arg Cys 
                325                 330                 335     


Val Glu Leu Phe Glu Ala Pro Val Glu Cys Glu Glu Glu Glu Glu Val 
            340                 345                 350         


Glu Glu Glu Lys Gly Ser Phe Cys Ala Ser Pro Glu Ser Ser Arg Asp 
        355                 360                 365             


Asp Phe Gln Glu Gly Arg Glu Gly Ile Val Ala Arg Leu Thr Glu Ser 
    370                 375                 380                 


Leu Phe Leu Asp Leu Leu Gly Glu Glu Asn Gly Gly Phe Cys Gln Gln 
385                 390                 395                 400 


Asp Met Gly Glu Ser Cys Leu Leu Pro Pro Ser Gly Ser Thr Ser Ala 
                405                 410                 415     


His Met Pro Trp Asp Glu Phe Pro Ser Ala Gly Pro Lys Glu Ala Pro 
            420                 425                 430         


Pro Trp Gly Lys Glu Gln Pro Leu His Leu Glu Pro Ser Pro Pro Ala 
        435                 440                 445             


Ser Pro Thr Gln Ser Pro Asp Asn Leu Thr Cys Thr Glu Thr Pro Leu 
    450                 455                 460                 


Val Ile Ala Gly Asn Pro Ala Tyr Arg Ser Phe Ser Asn Ser Leu Ser 
465                 470                 475                 480 


Gln Ser Pro Cys Pro Arg Glu Leu Gly Pro Asp Pro Leu Leu Ala Arg 
                485                 490                 495     


His Leu Glu Glu Val Glu Pro Glu Met Pro Cys Val Pro Gln Leu Ser 
            500                 505                 510         


Glu Pro Thr Thr Val Pro Gln Pro Glu Pro Glu Thr Trp Glu Gln Ile 
        515                 520                 525             


Leu Arg Arg Asn Val Leu Gln His Gly Ala Ala Ala Ala Pro Val Ser 
    530                 535                 540                 


Ala Pro Thr Ser Gly Tyr Gln Glu Phe Val His Ala Val Glu Gln Gly 
545                 550                 555                 560 


Gly Thr Gln Ala Ser Ala Val Val Gly Leu Gly Pro Pro Gly Glu Ala 
                565                 570                 575     


Gly Tyr Lys Ala Phe Ser Ser Leu Leu Ala Ser Ser Ala Val Ser Pro 
            580                 585                 590         


Glu Lys Cys Gly Phe Gly Ala Ser Ser Gly Glu Glu Gly Tyr Lys Pro 
        595                 600                 605             


Phe Gln Asp Leu Ile Pro Gly Cys Pro Gly Asp Pro Ala Pro Val Pro 
    610                 615                 620                 


Val Pro Leu Phe Thr Phe Gly Leu Asp Arg Glu Pro Pro Arg Ser Pro 
625                 630                 635                 640 


Gln Ser Ser His Leu Pro Ser Ser Ser Pro Glu His Leu Gly Leu Glu 
                645                 650                 655     


Pro Gly Glu Lys Val Glu Asp Met Pro Lys Pro Pro Leu Pro Gln Glu 
            660                 665                 670         


Gln Ala Thr Asp Pro Leu Val Asp Ser Leu Gly Ser Gly Ile Val Tyr 
        675                 680                 685             


Ser Ala Leu Thr Cys His Leu Cys Gly His Leu Lys Gln Cys His Gly 
    690                 695                 700                 


Gln Glu Asp Gly Gly Gln Thr Pro Val Met Ala Ser Pro Cys Cys Gly 
705                 710                 715                 720 


Cys Cys Cys Gly Asp Arg Ser Ser Pro Pro Thr Thr Pro Leu Arg Ala 
                725                 730                 735     


Pro Asp Pro Ser Pro Gly Gly Val Pro Leu Glu Ala Ser Leu Cys Pro 
            740                 745                 750         


Ala Ser Leu Ala Pro Ser Gly Ile Ser Glu Lys Ser Lys Ser Ser Ser 
        755                 760                 765             


Ser Phe His Pro Ala Pro Gly Asn Ala Gln Ser Ser Ser Gln Thr Pro 
    770                 775                 780                 


Lys Ile Val Asn Phe Val Ser Val Gly Pro Thr Tyr Met Arg Val Ser 
785                 790                 795                 800 


<210> 39
<211> 2400
<212> DNA
<213> Homo sapiens

<400> 39
atgaaggtct tgcaggagcc cacctgcgtc tccgactaca tgagcatctc tacttgcgag       60

tggaagatga atggtcccac caattgcagc accgagctcc gcctgttgta ccagctggtt      120

tttctgctct ccgaagccca cacgtgtatc cctgagaaca acggaggcgc ggggtgcgtg      180

tgccacctgc tcatggatga cgtggtcagt gcggataact atacactgga cctgtgggct      240

gggcagcagc tgctgtggaa gggctccttc aagcccagcg agcatgtgaa acccagggcc      300

ccaggaaacc tgacagttca caccaatgtc tccgacactc tgctgctgac ctggagcaac      360

ccgtatcccc ctgacaatta cctgtataat catctcacct atgcagtcaa catttggagt      420

gaaaacgacc cggcagattt cagaatctat aacgtgacct acctagaacc ctccctccgc      480

atcgcagcca gcaccctgaa gtctgggatt tcctacaggg cacgggtgag ggcctgggct      540

cagtgctata acaccacctg gagtgagtgg agccccagca ccaagtggca caactcctac      600

agggagccct tcgagcagca cctcctgctg ggcgtcagcg tttcctgcat tgtcatcctg      660

gccgtctgcc tgttgtgcta tgtcagcatc accaagatta agaaagaatg gtgggatcag      720

attcccaacc cagcccgcag ccgcctcgtg gctataataa tccaggatgc tcaggggtca      780

cagtgggaga agcggtcccg aggccaggaa ccagccaagt gcccacactg gaagaattgt      840

cttaccaagc tcttgccctg ttttctggag cacaacatga aaagggatga agatcctcac      900

aaggctgcca aagagatgcc tttccagggc tctggaaaat cagcatggtg cccagtggag      960

atcagcaaga cagtcctctg gccagagagc atcagcgtgg tgcgatgtgt ggagttgttt     1020

gaggccccgg tggagtgtga ggaggaggag gaggtagagg aagaaaaagg gagcttctgt     1080

gcatcgcctg agagcagcag ggatgacttc caggagggaa gggagggcat tgtggcccgg     1140

ctaacagaga gcctgttcct ggacctgctc ggagaggaga atgggggctt ttgccagcag     1200

gacatggggg agtcatgcct tcttccacct tcgggaagta cgagtgctca catgccctgg     1260

gatgagttcc caagtgcagg gcccaaggag gcacctccct ggggcaagga gcagcctctc     1320

cacctggagc caagtcctcc tgccagcccg acccagagtc cagacaacct gacttgcaca     1380

gagacgcccc tcgtcatcgc aggcaaccct gcttaccgca gcttcagcaa ctccctgagc     1440

cagtcaccgt gtcccagaga gctgggtcca gacccactgc tggccagaca cctggaggaa     1500

gtagaacccg agatgccctg tgtcccccag ctctctgagc caaccactgt gccccaacct     1560

gagccagaaa cctgggagca gatcctccgc cgaaatgtcc tccagcatgg ggcagctgca     1620

gcccccgtct cggcccccac cagtggctat caggagtttg tacatgcggt ggagcagggt     1680

ggcacccagg ccagtgcggt ggtgggcttg ggtcccccag gagaggctgg ttacaaggcc     1740

ttctcaagcc tgcttgccag cagtgctgtg tccccagaga aatgtgggtt tggggctagc     1800

agtggggaag aggggtataa gcctttccaa gacctcattc ctggctgccc tggggaccct     1860

gccccagtcc ctgtcccctt gttcaccttt ggactggaca gggagccacc tcgcagtccg     1920

cagagctcac atctcccaag cagctcccca gagcacctgg gtctggagcc gggggaaaag     1980

gtagaggaca tgccaaagcc cccacttccc caggagcagg ccacagaccc ccttgtggac     2040

agcctgggca gtggcattgt ctactcagcc cttacctgcc acctgtgcgg ccacctgaaa     2100

cagtgtcatg gccaggagga tggtggccag acccctgtca tggccagtcc ttgctgtggc     2160

tgctgctgtg gagacaggtc ctcgccccct acaacccccc tgagggcccc agacccctct     2220

ccaggtgggg ttccactgga ggccagtctg tgtccggcct ccctggcacc ctcgggcatc     2280

tcagagaaga gtaaatcctc atcatccttc catcctgccc ctggcaatgc tcagagctca     2340

agccagaccc ccaaaatcgt gaactttgtc tccgtgggac ccacatacat gagggtctct     2400


<210> 40
<211> 291
<212> PRT
<213> Homo sapiens

<400> 40
Met Gly Ile Leu Ser Phe Leu Pro Val Leu Ala Thr Glu Ser Asp Trp 
1               5                   10                  15      


Ala Asp Cys Lys Ser Pro Gln Pro Trp Gly His Met Leu Leu Trp Thr 
            20                  25                  30          


Ala Val Leu Phe Leu Ala Pro Val Ala Gly Thr Pro Ala Ala Pro Pro 
        35                  40                  45              


Lys Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu 
    50                  55                  60                  


Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp 
65                  70                  75                  80  


Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln 
                85                  90                  95      


Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr 
            100                 105                 110         


Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val 
        115                 120                 125             


Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu 
    130                 135                 140                 


Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu 
145                 150                 155                 160 


Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg 
                165                 170                 175     


Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly 
            180                 185                 190         


Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys 
        195                 200                 205             


Pro Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro Met Gly Ile 
    210                 215                 220                 


Ile Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala Ala 
225                 230                 235                 240 


Val Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Asn Pro 
                245                 250                 255     


Thr Asn Pro Asp Glu Ala Asp Lys Val Gly Ala Glu Asn Thr Ile Thr 
            260                 265                 270         


Tyr Ser Leu Leu Met His Pro Asp Ala Leu Glu Glu Pro Asp Asp Gln 
        275                 280                 285             


Asn Arg Ile 
    290     


<210> 41
<211> 876
<212> DNA
<213> Homo sapiens

<400> 41
atgggaatcc tgtcattctt acctgtcctt gccactgaga gtgactgggc tgactgcaag       60

tccccccagc cttggggtca tatgcttctg tggacagctg tgctattcct ggctcctgtt      120

gctgggacac ctgcagctcc cccaaaggct gtgctgaaac tcgagcccca gtggatcaac      180

gtgctccagg aggactctgt gactctgaca tgccggggga ctcacagccc tgagagcgac      240

tccattcagt ggttccacaa tgggaatctc attcccaccc acacgcagcc cagctacagg      300

ttcaaggcca acaacaatga cagcggggag tacacgtgcc agactggcca gaccagcctc      360

agcgaccctg tgcatctgac tgtgctttct gagtggctgg tgctccagac ccctcacctg      420

gagttccagg agggagaaac catcgtgctg aggtgccaca gctggaagga caagcctctg      480

gtcaaggtca cattcttcca gaatggaaaa tccaagaaat tttcccgttc ggatcccaac      540

ttctccatcc cacaagcaaa ccacagtcac agtggtgatt accactgcac aggaaacata      600

ggctacacgc tgtactcatc caagcctgtg accatcactg tccaagctcc cagctcttca      660

ccgatgggga tcattgtggc tgtggtcact gggattgctg tagcggccat tgttgctgct      720

gtagtggcct tgatctactg caggaaaaag cggatttcag ccaatcccac taatcctgat      780

gaggctgaca aagttggggc tgagaacaca atcacctatt cacttctcat gcacccggat      840

gctctggaag agcctgatga ccagaaccgt atttag                                876


<210> 42
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  



