
                                SEQUENCE LISTING

<110> Chemgenes Corporation

<120> Phosphoramidites for Synthetic RNA in
  the Reverse Direction

<130> 4441.1001-003

<140> PCT/US2011/025488   
<141> 2011-02-18  

<150> 12/708,827          
<151> 2010-02-19  

<150> PCT/US2009/005063   
<151> 2009-09-08  

<150> 61/191,065          
<151> 2008-09-06  

<160> 11

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> All c's, a's, g's and u's are ribonucleic acids

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> Internucleotide linkage formed by BTT (5-Benzyl
      thio-1-1H-tetrazole) activator

<220> 
<221> misc_feature   
<222> 2, 21
<223> Adenosine is
      N6-Benzoyl-2'-O-Me-3'-O-DMT-adenosine-OP


<220> 
<221> misc_feature   
<222> (3)...(20)
<223> All a's are
      N6-Benzoyl-2'-O-TBDMS-3'-O-DMT-adenosine-OP;
      all c's are
      N4-Acetyl-2'-O-TBDMS-3'-O-DMT-cytidine-OP


<220> 
<221> misc_feature   
<222> (1)...(21)
<223> all g's are
      N2-Isobutryl-2'-O-TBDMS-3'-O-DMT-guanosine-OP;
      all u's are 2'-O-TBDMS-3'-O-DMT-uridine-OP

<400> 1
uaccagcucu acauacgaca a                                           21

<210> 2
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> All c's, a's, g's and u's are ribonucleic acids

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> Phosphorothioate internucleotide linkage

<220> 
<221> misc_feature   
<222> 2, 21
<223> Adenosine is
      N6-Benzoyl-2'-O-Me-3'-O-DMT-adenosine-OP


<220> 
<221> misc_feature   
<222> (3)...(20)
<223> All a's are
      N6-Benzoyl-2'-O-TBDMS-3'-O-DMT-adenosine-OP;
      all c's are
      N4-Acetyl-2'-O-TBDMS-3'-O-DMT-cytidine-OP


<220> 
<221> misc_feature   
<222> (1)...(21)
<223> all g's are
      N2-Isobutryl-2'-O-TBDMS-3'-O-DMT-guanosine-OP;
      all u's are 2'-O-TBDMS-3'-O-DMT-uridine-OP

<400> 2
uaccagcucu acauacgaca a                                           21

<210> 3
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> All c's, a's, g's and u's are ribonucleic acids

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> Phosphodiester internucleotide linkage

<220> 
<221> misc_feature   
<222> 2, 21
<223> a is N6-Benzoyl-2'-O-Me-3'-O-DMT-adenosine-OP


<220> 
<221> misc_feature   
<222> (3)...(20)
<223> All a's are
      N6-Benzoyl-2'-O-TBDMS-3'-O-DMT-adenosine-OP;
      all c's are
      N4-Acetyl-2'-O-TBDMS-3'-O-DMT-cytidine-OP


<220> 
<221> misc_feature   
<222> (1)...(21)
<223> all g's are
      N2-Isobutryl-2'-O-TBDMS-3'-O-DMT-guanosine-OP;
      all u's are 2'-O-TBDMS-3'-O-DMT-uridine-OP

<400> 3
uaccagcucu acauacgaca a                                           21

<210> 4
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> All c's, a's, g's and u's are ribonucleic acids

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> All a's are
      N6-Benzoyl-2'-O-TBDMS-3'-O-DMT-adenosine-OP;
      all c's are
      N4-Acetyl-2'-O-TBDMS-3'-O-DMT-cytidine-OP

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> all g's are
      N2-Isobutryl-2'-O-TBDMS-3'-O-DMT-guanosine-OP;
      all u's are 2'-O-TBDMS-3'-O-DMT-uridine-OP

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> Phosphodiester internucleotide linkage

<400> 4
uaccagcucu acauacgaca c                                           21

<210> 5
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> All c's, a's, g's and u's are ribonucleic acids.

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> Phosphothioate internucleotide linkage

<220> 
<221> misc_feature   
<222> 2, 21
<223> Adenosine is
      N6-Benzoyl-2'-O-Me3'-O-DMT-adenosine-OP

<220> 
<221> misc_feature   
<222> (3)...(20)
<223> All a's are
      N6-Benzoyl-2'-O-TBDMS-3'-O-DMT-adenosine-OP;
      all c's are
      N4-Acetyl-2'-O-TBDMS-3'-O-DMT-cytidine-OP
      


<220> 
<221> misc_feature   
<222> (1)...(21)
<223> all g's are
      N2-Isobutryl-2'-O-TBDMS-3'-O-DMT-guanosine-OP;
      all u's are 2'-O-TBDMS-3'-O-DMT-uridine-OP
      

<400> 5
uaccagcucu acauacgaca a                                           21

<210> 6
<211> 18
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<220> 
<221> misc_feature   
<222> (1)...(18)
<223> All c's, a's, g's and u's are ribonucleic acids

<220> 
<221> misc_feature   
<222> 18
<223> -(OPO3-PEG-2000)2 attached to 3' terminal

<400> 6
uaccucgacu guagagcu                                               18

<210> 7
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> All c's, a's, g's and u's are ribonucleic acids.

<220> 
<221> misc_feature   
<222> 2, 21
<223> a is N6-Benzoyl-2'-O-Me-3'-O-DMT-adenosine-OP

<220> 
<221> misc_feature   
<222> (3)...(20)
<223> All a's are
      N6-Benzoyl-2'-O-TBDMS-3'-O-DMT-adenosine-OP;
      all c's are
      N4-Acetyl-2'-O-TBDMS-3'-O-DMT-cytidine-OP

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> all g's are
      N2-Isobutryl-2'-O-TBDMS-3'-O-DMT-guanosine-OP;
      all u's are 2'-O-TBDMS-3'-O-DMT-uridine-OP


<220> 
<221> misc_feature   
<222> (1)...(21)
<223> Phosphorothioate internucleotide linkage

<400> 7
uaccagcucu acauacgaca a                                           21

<210> 8
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> All c's, a's, g's and u's are ribonucleic acids.

<220> 
<221> misc_feature   
<222> 2, 21
<223> a is N6-Benzoyl-2'-O-Me-3'-O-DMT-adenosine-OP

<220> 
<221> misc_feature   
<222> (3)...(20)
<223> All a's are
      N6-Benzoyl-2'-O-TBDMS-3'-O-DMT-adenosine-OP;
      all c's are
      N4-Acetyl-2'-O-TBDMS-3'-O-DMT-cytidine-OP


<220> 
<221> misc_feature   
<222> (1)...(21)
<223> all g's are
      N2-Isobutryl-2'-O-TBDMS-3'-O-DMT-guanosine-OP;
      all u's are 2'-O-TBDMS-3'-O-DMT-uridine-OP

<400> 8
uaccagcucu acauacgaca a                                           21

<210> 9
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> All c's, a's, g's and u's are ribonucleic acids.

<220> 
<221> misc_feature   
<222> 2, 21
<223> a is N6-Benzoyl-2'-O-Me-3'-O-DMT-adenosine-OP

<220> 
<221> misc_feature   
<222> (3)...(20)
<223> All a's are
      N6-Benzoyl-2'-O-TBDMS-3'-O-DMT-adenosine-OP;
      all c's are
      N4-Acetyl-2'-O-TBDMS-3'-O-DMT-cytidine-OP


<220> 
<221> misc_feature   
<222> (1)...(21)
<223> all g's are
      N2-Isobutryl-2'-O-TBDMS-3'-O-DMT-guanosine-OP;
      all u's are 2'-O-TBDMS-3'-O-DMT-uridine-OP


<220> 
<221> misc_feature   
<222> (1)...(21)
<223> Phosphorothioate internucleotide linkage

<400> 9
uaccagcucu acauacgaca a                                           21

<210> 10
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> All c's, a's, g's and u's are ribonucleic acids.

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> All a's are
      N6-Benzoyl-2'-O-TBDMS-3'-O-DMT-adenosine-OP;
      all c's are
      N4-Acetyl-2'-O-TBDMS-3'-O-DMT-cytidine-OP

<220> 
<221> misc_feature   
<222> (1)...(21)
<223> all g's are
      N2-Isobutryl-2'-O-TBDMS-3'-O-DMT-guanosine-OP;
      all u's are 2'-O-TBDMS-3'-O-DMT-uridine-OP

<400> 10
uaccagcucu acauacgaca c                                           21

<210> 11
<211> 76
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<220> 
<221> misc_feature   
<222> (1)...(76)
<223> All c's, a's, g's and u's are ribonucleic acids.

<220> 
<221> misc_feature   
<222> (1)...(76)
<223> All a's are
      N6-Benzoyl-2'-O-TBDMS-3'-O-DMT-adenosine-OP;
      all c's are
      N4-Acetyl-2'-O-TBDMS-3'-O-DMT-cytidine-OP

<220> 
<221> misc_feature   
<222> (1)...(76)
<223> all g's are
      N2-Isobutryl-2'-O-TBDMS-3'-O-DMT-guanosine-OP;
      all u's are 2'-O-TBDMS-3'-O-DMT-uridine-OP

<400> 11
gcccggauag cucagucggu agagcaucag acuuuuuauc ugagggucca ggguucaagu 60
cccuguucgg gcgcca                                                 76
