                         SEQUENCE LISTING

<110>  San Diego State University (SDSU) Foundation
       GOTTLIEB, Roberta A
 
<120>  COMPOSITIONS AND METHODS FOR MODULATING AUTOPHAGY

<130>  00038-027WO1/GottliebR3

<140>  not yet assigned
<141>  2011-02-25

<150>  61/308,257
<151>  2010-02-25

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  347
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide or nucleic acid

<400>  1

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Arg Trp Gly Ser Lys Leu Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg 
        35                  40                  45              


Arg Arg Gly Gly Ser Thr Met Ser Gly Tyr Pro Tyr Asp Val Pro Asp 
    50                  55                  60                  


Tyr Ala Gly Ser Met Ala Gly Thr Met Thr Asp Asp Lys Asp Val Leu 
65                  70                  75                  80  


Arg Asp Val Trp Phe Gly Arg Ile Pro Thr Cys Phe Thr Leu Tyr Gln 
                85                  90                  95      


Asp Glu Ile Thr Glu Arg Glu Ala Glu Pro Tyr Tyr Leu Leu Leu Pro 
            100                 105                 110         


Arg Val Ser Tyr Leu Thr Leu Val Thr Asp Lys Val Lys Lys His Phe 
        115                 120                 125             


Gln Lys Val Met Arg Gln Glu Asp Val Ser Glu Ile Trp Phe Glu Tyr 
    130                 135                 140                 


Glu Gly Thr Pro Leu Lys Trp His Tyr Pro Ile Gly Leu Leu Phe Asp 
145                 150                 155                 160 


Leu Leu Ala Ser Ser Ser Ala Leu Pro Trp Asn Ile Thr Val His Phe 
                165                 170                 175     


Lys Ser Phe Pro Glu Lys Asp Leu Leu His Cys Pro Ser Lys Asp Ala 
            180                 185                 190         


Val Glu Ala His Phe Met Ser Cys Met Arg Glu Ala Asp Ala Leu Lys 
        195                 200                 205             


His Lys Ser Gln Val Ile Asn Glu Met Gln Lys Lys Asp His Lys Gln 
    210                 215                 220                 


Leu Trp Met Gly Leu Gln Asn Asp Arg Phe Asp Gln Phe Trp Ala Ile 
225                 230                 235                 240 


Asn Arg Lys Leu Met Glu Tyr Pro Pro Glu Glu Asn Gly Phe Arg Tyr 
                245                 250                 255     


Ile Pro Phe Arg Ile Tyr Gln Thr Thr Thr Glu Arg Pro Phe Ile Gln 
            260                 265                 270         


Lys Leu Phe Arg Pro Val Ala Ala Asp Gly Gln Leu His Thr Leu Gly 
        275                 280                 285             


Asp Leu Leu Arg Glu Val Cys Pro Ser Ala Val Ala Pro Glu Asp Gly 
    290                 295                 300                 


Glu Lys Arg Ser Gln Val Met Ile His Gly Ile Glu Pro Met Leu Glu 
305                 310                 315                 320 


Thr Pro Leu Gln Trp Leu Ser Glu His Leu Ser Tyr Pro Asp Asn Phe 
                325                 330                 335     


Leu His Ile Ser Ile Val Pro Gln Pro Thr Asp 
            340                 345         


<210>  2
<211>  1044
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic nucleic acid

<400>  2
atgcggggtt ctcatcatca tcatcatcat ggtatggcta gcatgactgg tggacagcaa       60

atgggtcggg atctgtacga cgatgacgat aaggatcgat ggggatccaa gcttggctac      120

ggccgcaaga aacgccgcca gcgccgccgc ggtggatcca ccatgtccgg ctatccatat      180

gacgtcccag actatgctgg ctccatggcc ggtaccatga cagatgacaa agatgtgctt      240

cgagatgtgt ggtttggacg aattccaact tgctttactc tctatcagga tgagataact      300

gaaagagaag cagaaccata ctatttgctt ttgccaagag tcagctattt gacgttggta      360

actgacaaag tgaaaaagca ctttcagaag gttatgagac aagaagatgt tagtgagata      420

tggtttgaat atgaaggcac acccctgaaa tggcattatc caattggttt actatttgat      480

cttcttgcat caagttcagc tcttccttgg aacatcacag tacatttcaa gagttttcca      540

gaaaaggacc ttctacactg tccatccaag gatgcggttg aggctcactt tatgtcgtgt      600

atgagagaag ctgatgcttt aaagcataaa agtcaagtga tcaacgaaat gcagaaaaaa      660

gaccacaagc agctctggat gggactgcag aatgacagat ttgaccagtt ttgggccatc      720

aaccggaaac tcatggaata tcctccagaa gaaaatggat ttcgttatat cccctttaga      780

atatatcaga ccacgacgga gcggcctttc atccagaagc tgttccggcc tgtggccgca      840

gatggacagc tgcacacact tggagatctc ctcagagaag tctgtccttc cgcagtcgcc      900

cctgaagatg gagagaagag gagccaggtg atgattcacg ggatagagcc aatgctggaa      960

acccctctgc agtggctgag cgagcatctg agctacccag ataactttct tcatattagc     1020

attgtccccc agccaacaga ttga                                            1044


<210>  3
<211>  523
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  3

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Arg Trp Gly Ser Lys Leu Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg 
        35                  40                  45              


Arg Arg Gly Gly Ser Thr Met Ser Gly Tyr Pro Tyr Asp Val Pro Asp 
    50                  55                  60                  


Tyr Ala Gly Ser Met Ala Gly Thr Gly Leu Glu Met Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Ser Ser Ser Thr Met Gln Val Ser Phe Val Cys Gln Arg Cys Ser 
                85                  90                  95      


Gln Pro Leu Lys Leu Asp Thr Ser Phe Lys Ile Leu Asp Arg Val Thr 
            100                 105                 110         


Ile Gln Glu Leu Thr Ala Pro Leu Leu Thr Thr Ala Gln Ala Lys Pro 
        115                 120                 125             


Gly Glu Ser Gln Glu Glu Glu Ala Asn Ser Gly Glu Glu Pro Phe Ile 
    130                 135                 140                 


Glu Thr Arg Gln Asp Gly Val Ser Arg Arg Phe Ile Pro Pro Ala Arg 
145                 150                 155                 160 


Met Met Ser Thr Glu Ser Ala Asn Ser Phe Thr Leu Ile Gly Glu Ala 
                165                 170                 175     


Ser Asp Gly Gly Thr Met Glu Asn Leu Ser Arg Arg Leu Lys Val Thr 
            180                 185                 190         


Gly Asp Leu Phe Asp Ile Met Ser Gly Gln Thr Asp Val Asp His Pro 
        195                 200                 205             


Leu Cys Glu Glu Cys Thr Asp Thr Leu Leu Asp Gln Leu Asp Thr Gln 
    210                 215                 220                 


Leu Asn Val Thr Glu Asn Glu Cys Gln Asn Tyr Lys Arg Cys Leu Glu 
225                 230                 235                 240 


Met Leu Glu Gln Met Asn Glu Gly Asp Ser Glu Gln Leu Gln Arg Glu 
                245                 250                 255     


Leu Lys Glu Leu Ala Leu Glu Glu Glu Arg Leu Ile Gln Glu Leu Glu 
            260                 265                 270         


Asp Val Glu Lys Asn Arg Lys Val Val Ala Glu Asn Leu Glu Lys Val 
        275                 280                 285             


Gln Ala Glu Ala Glu Arg Leu Asp Gln Glu Glu Ala Gln Tyr Gln Arg 
    290                 295                 300                 


Glu Tyr Ser Glu Phe Lys Arg Gln Gln Leu Glu Leu Asp Asp Glu Leu 
305                 310                 315                 320 


Lys Ser Val Glu Asn Gln Met Arg Tyr Ala Gln Met Gln Leu Asp Lys 
                325                 330                 335     


Leu Lys Lys Thr Asn Val Phe Asn Ala Thr Phe His Ile Trp His Ser 
            340                 345                 350         


Gly Gln Phe Gly Thr Ile Asn Asn Phe Arg Leu Gly Arg Leu Pro Ser 
        355                 360                 365             


Ala Pro Val Glu Trp Asn Glu Ile Asn Ala Ala Trp Gly Gln Thr Val 
    370                 375                 380                 


Leu Leu Leu His Ala Leu Ala Asn Lys Met Gly Leu Lys Phe Gln Arg 
385                 390                 395                 400 


Tyr Arg Leu Val Pro Tyr Gly Asn His Ser Tyr Leu Glu Ser Leu Thr 
                405                 410                 415     


Asp Lys Ser Lys Glu Leu Pro Leu Tyr Cys Ser Gly Gly Leu Arg Phe 
            420                 425                 430         


Phe Trp Asp Asn Lys Phe Asp His Ala Met Val Ala Phe Leu Asp Cys 
        435                 440                 445             


Val Gln Gln Phe Lys Glu Glu Val Glu Lys Gly Glu Thr Arg Phe Cys 
    450                 455                 460                 


Leu Pro Tyr Arg Met Asp Val Glu Lys Gly Lys Ile Glu Asp Thr Gly 
465                 470                 475                 480 


Gly Ser Gly Gly Ser Tyr Ser Ile Lys Thr Gln Phe Asn Ser Glu Glu 
                485                 490                 495     


Gln Trp Thr Lys Ala Leu Lys Phe Met Leu Thr Asn Leu Lys Trp Gly 
            500                 505                 510         


Leu Ala Trp Val Ser Ser Gln Phe Tyr Asn Lys 
        515                 520             


<210>  4
<211>  1572
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic nucleic acid

<400>  4
atgcggggtt ctcatcatca tcatcatcat ggtatggcta gcatgactgg tggacagcaa       60

atgggtcggg atctgtacga cgatgacgat aaggatcgat ggggatccaa gcttggctac      120

ggccgcaaga aacgccgcca gcgccgccgc ggtggatcca ccatgtccgg ctatccatat      180

gacgtcccag actatgctgg ctccatggcc ggtaccggtc tcgagatgga ggggtctaag      240

gcgtccagca gcaccatgca ggtgagcttc gtgtgccagc gctgtagcca gcctctgaaa      300

ctggacacga gcttcaagat cctggaccga gtgaccattc aggaactcac agctccatta      360

cttaccacag cccaggcgaa accaggagag agccaggagg aagaggctaa ctcaggagag      420

gagccattta ttgaaactcg ccaggatggt gtctctcgaa gattcatccc cccagccagg      480

atgatgtcta cagaaagtgc taatagcttc actctgatcg gggaggcatc tgatggtggc      540

accatggaga acctcagccg gagactcaag gtcactggag acctttttga catcatgtct      600

ggccagacag atgtggatca cccactgtgt gaggaatgca cagatactct tttagaccag      660

ctggacactc agctcaatgt tactgaaaac gagtgtcaga actacaaacg ctgtttggag      720

atgttggagc aaatgaatga gggcgacagt gaacagctac agagggagct gaaggagttg      780

gccttggagg aggagaggct gatccaggag ctggaagatg tggaaaaaaa ccgaaaggtg      840

gtggcagaaa acctggagaa ggtccaggct gaggcggaga gactggacca ggaggaagct      900

cagtaccagc gagaatatag tgaatttaaa aggcagcagc tggagctgga tgatgagctc      960

aagagtgtag agaaccagat gcgctatgcc cagatgcagc tggacaagct caagaaaacc     1020

aatgtcttca atgcgacctt ccatatctgg cacagcggac aatttggcac gatcaataat     1080

ttcagactgg gtcgcttgcc cagtgctcct gtggaatgga atgaaatcaa tgctgcctgg     1140

ggccagacag tgttgttgct ccatgctttg gccaataaga tgggtctgaa atttcagagg     1200

taccgacttg ttccctatgg aaatcactcg tatctggagt ccctgacaga caaatctaag     1260

gagttgccgt tgtactgttc tgggggtttg cggtttttct gggacaacaa gtttgaccat     1320

gcaatggtag cttttctgga ctgtgtgcag cagttcaaag aagaggtgga aaaaggagag     1380

actcgatttt gtcttccgta caggatggac gtggagaaag gcaagattga agacactgga     1440

ggcagtggcg gctcctattc catcaaaacc cagtttaact ctgaggagca gtggacaaag     1500

gcgctcaagt tcatgctgac gaatctcaag tggggtcttg cttgggtgtc ctcacagttc     1560

tataacaagt ga                                                         1572


<210>  5
<211>  293
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  5

Met Arg Gly Ser Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly 
1               5                   10                  15      


Gly Ser Met Thr Asp Asp Lys Asp Val Leu Arg Asp Val Trp Phe Gly 
            20                  25                  30          


Arg Ile Pro Thr Cys Phe Thr Leu Tyr Gln Asp Glu Ile Thr Glu Arg 
        35                  40                  45              


Glu Ala Glu Pro Tyr Tyr Leu Leu Leu Pro Arg Val Ser Tyr Leu Thr 
    50                  55                  60                  


Leu Val Thr Asp Lys Val Lys Lys His Phe Gln Lys Val Met Arg Gln 
65                  70                  75                  80  


Glu Asp Ile Ser Glu Ile Trp Phe Glu Tyr Glu Gly Thr Pro Leu Lys 
                85                  90                  95      


Trp His Tyr Pro Ile Gly Leu Leu Phe Asp Leu Leu Ala Ser Ser Ser 
            100                 105                 110         


Ala Leu Pro Trp Asn Ile Thr Val His Phe Lys Ser Phe Pro Glu Lys 
        115                 120                 125             


Asp Leu Leu His Cys Pro Ser Lys Asp Ala Ile Glu Ala His Phe Met 
    130                 135                 140                 


Ser Cys Met Arg Glu Ala Asp Ala Leu Lys His Lys Ser Gln Val Ile 
145                 150                 155                 160 


Asn Glu Met Gln Lys Lys Asp His Lys Gln Leu Trp Met Gly Leu Gln 
                165                 170                 175     


Asn Asp Arg Phe Asp Gln Phe Trp Ala Ile Asn Arg Lys Leu Met Glu 
            180                 185                 190         


Tyr Pro Ala Glu Glu Asn Gly Phe Arg Tyr Ile Pro Phe Arg Ile Tyr 
        195                 200                 205             


Gln Thr Thr Thr Glu Arg Pro Phe Ile Gln Lys Leu Phe Arg Pro Val 
    210                 215                 220                 


Ala Ala Asp Gly Gln Leu His Thr Leu Gly Asp Leu Leu Lys Glu Val 
225                 230                 235                 240 


Cys Pro Ser Ala Ile Asp Pro Glu Asp Gly Glu Lys Lys Asn Gln Val 
                245                 250                 255     


Met Ile His Gly Ile Glu Pro Met Leu Glu Thr Pro Leu Gln Trp Leu 
            260                 265                 270         


Ser Glu His Leu Ser Tyr Pro Asp Asn Phe Leu His Ile Ser Ile Ile 
        275                 280                 285             


Pro Gln Pro Thr Asp 
    290             


<210>  6
<211>  3244
<212>  DNA
<213>  Homo sapiens

<400>  6
gtgacgtcat ctccgggcgc cgagggtgac tggacttgtg gtgcgctgcc agggctccgc       60

agcgttgccg gttgtattcg ctggatacca gagggcggaa gtgcagcagg gttcagctcc      120

gacctccgcg ccggtgcttt ttgcggctgc gcgggcttcc tggagtcctg ctaccgcgtc      180

cccgcaggac agtgtgtcag gcgggcagct tgccccgccg ccccaccgga gcgcggaatc      240

tgggcgtccc caccagtgcg gggagccgga aggaggagcc atagcttgga gtaggtttgg      300

ctttggttga aataagaatt tagcctgtat gtactgcttt aactcctgga agaatgacag      360

atgacaaaga tgtgcttcga gatgtgtggt ttggacgaat tccaacttgt ttcacgctat      420

atcaggatga gataactgaa agggaagcag aaccatacta tttgcttttg ccaagagtaa      480

gttatttgac gttggtaact gacaaagtga aaaagcactt tcagaaggtt atgagacaag      540

aagacattag tgagatatgg tttgaatatg aaggcacacc actgaaatgg cattatccaa      600

ttggtttgct atttgatctt cttgcatcaa gttcagctct tccttggaac atcacagtac      660

attttaagag ttttccagaa aaagaccttc tgcactgtcc atctaaggat gcaattgaag      720

ctcattttat gtcatgtatg aaagaagctg atgctttaaa acataaaagt caagtaatca      780

atgaaatgca gaaaaaagat cacaagcaac tctggatggg attgcaaaat gacagatttg      840

accagttttg ggccatcaat cggaaactca tggaatatcc tgcagaagaa aatggatttc      900

gttatatccc ctttagaata tatcagacaa cgactgaaag acctttcatt cagaagctgt      960

ttcgtcctgt ggctgcagat ggacagttgc acacactagg agatctcctc aaagaagttt     1020

gtccttctgc tattgatcct gaagatgggg aaaaaaagaa tcaagtgatg attcatggaa     1080

ttgagccaat gttggaaaca cctctgcagt ggctgagtga acatctgagc tacccggata     1140

attttcttca tattagtatc atcccacagc caacagattg aaggatcaac tatttgcctg     1200

aacagaatca tccttaaatg ggatttatca gagcatgtca cccttttgct tcaatcaggt     1260

ttggtggagg caacctgacc agaaacactt cgctgctgca agccagacag gaaaaagatt     1320

ccatgtcaga taaggcaact gggctggtct tactttgcat cacctctgct ttcctccact     1380

gccatcatta aacctcagct gtgacatgaa agacttaccg gaccactgaa ggtcttctgt     1440

aaaatataat gaagctgaaa cctttggcct aagaagaaaa tggaagtatg tgccactcga     1500

tttgtatttc tgattaacaa ataaacaggg gtatttccta aggtgaccat ggttgaactt     1560

tagctcatga aagtggaaac attggtttaa ttttcaagag aattaagaaa gtaaaagaga     1620

aattctgtta tcaataactt gcaagtaatt ttttgtaaaa gattgaatta cagtaaaccc     1680

atctttcctt aacgaaaatt tcctatgttt acagtctgtc tattggtatg caatcttgta     1740

actttgataa tgaacagtga gagattttta aataaagcct ctaaatatgt tttgtcattt     1800

aataacatac agttttgtca cttttcaagt actttctgac tcacatacag tagatcactt     1860

tttactctgt gttaccattt tgactggtcg tcattggcat ggggtggata tagggcatag     1920

gattacttgt ctcagaagct gtcatagaat ttcttgctgc caattaaaaa acctgtgttc     1980

tttacacact acacgtataa atattgtaac tgttcatctt tgttgtttta tcactgtaag     2040

cctgtcaaat catagtatcc taagcatctg taaatgctaa ttttgcattt ttggaaaaac     2100

ccattccttc caagctagtg tttttcattg gctccaggtc taatttttca ctgtggtccc     2160

tggcagccag tcttttgaag tttaaagatt acctgtctct tgactgcagt accttttctt     2220

taatttttac caaaaatatc cagaggttac tggagttctt attcaatata aggaaagttt     2280

gctgcacttt attaccaagc ctctgggatt ttaccagtca aacatatttg tgcattacat     2340

ttcatttctt gtgagctagc tggctgtcca tattgaatgt tgacccattt gagtacgcta     2400

aaaggcttac agtatcagac acgatcatgg ttttagatcc cataataaaa atgaatgttt     2460

ttcttataaa aaattataca aatgctgaag tgagattcta ctattgttca ttgcttcctt     2520

ttctttttcc ttttgcgatt ttcactgatt aatagcacat ttcttcacaa aattagataa     2580

agttggtcaa agaccagata ttctggaatg gaaattgtaa agcttaatca aaaagaatag     2640

ccagtacagc atacaatctc agaaacttag aagcaagtag aaaataattg gttgatgtaa     2700

acgaaagtgc cattttagta aaggcaggaa aaaaatagca atatttgagt tatgtaagga     2760

taaaaaatcc actgacttgt atttttgcac aagaggctgg tctgaatatg attgttcaca     2820

ttaagagtgt ttattcgtcg gttcattttg gggattttcc cccttgatgt tttgacagat     2880

tgaagtgagc tttagtgagc aaaaggatca gaatgcaggg aacactaagc tgtgatgaag     2940

aaagtgtggt aaaaagccag agtagtttta tacagacaaa accagtgtca ggcctttgca     3000

gtaggcttga gtgaacttct gatctagatt tgaaagtaaa ttttatgaag acattgccca     3060

tttttacttc ctcattcatt attgtaccag catcatagct ttattactct aatcccaggt     3120

aagtcaagcc tacaatgccc tagaggaaga gtaaaaccag aaattcatgc tggcttaaat     3180

aatctatttt tgtttctttt catttgaata tttaaatttt atggtttatt aaaaaattaa     3240

ataa                                                                  3244


<210>  7
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  7

Met His Tyr Pro Ile Gly Leu Leu Phe Asp Leu Leu Ala Ser Ser Ser 
1               5                   10                  15      


Ala Leu Pro Trp Asn Ile Thr Val His Phe Lys Ser Phe Pro Glu Lys 
            20                  25                  30          


Asp Leu Leu His Cys Pro Ser Lys Asp Ala Ile Glu Ala His Phe Met 
        35                  40                  45              


Ser Cys Met Lys Glu Ala Asp Ala Leu Lys His Lys Ser Gln Val Ile 
    50                  55                  60                  


Asn Glu Met Gln Lys Lys Asp His Lys Gln Leu Trp Met Gly Leu Gln 
65                  70                  75                  80  


Asn Asp Arg Phe Asp Gln Phe Trp Ala Ile Asn Arg Lys Leu Met Glu 
                85                  90                  95      


Tyr Pro Ala Glu Glu Asn Gly Phe Arg Tyr Ile Pro Phe Arg Ile Tyr 
            100                 105                 110         


Gln Thr Thr Thr Glu Arg Pro Phe Ile Gln Lys Leu Phe Arg Pro Val 
        115                 120                 125             


Ala Ala Asp Gly Gln Leu His Thr Leu Gly Asp Leu Leu Lys Glu Val 
    130                 135                 140                 


Cys Pro Ser Ala Ile Asp Pro Glu Asp Gly Glu Lys Lys Asn Gln Val 
145                 150                 155                 160 


Met Ile His Gly Ile Glu Pro Met Leu Glu Thr Pro Leu Gln Trp Leu 
                165                 170                 175     


Ser Glu His Leu Ser Tyr Pro Asp Asn Phe Leu His Ile Ser Ile Ile 
            180                 185                 190         


Pro Gln Pro Thr Asp 
        195         


