                         SEQUENCE LISTING

<110>  Boehringer Ingelheim International GmbH
 
<120>  A-BETA BINDING POLYPEPTIDES

<130>  P01-2596

<150>  EP 10 155 339.4
<151>  2010-03-03

<160>  153   

<170>  PatentIn version 3.3

<210>  1
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  2
<211>  40
<212>  PRT
<213>  Mus musculus

<400>  2

Asp Ala Glu Phe Gly His Asp Ser Gly Phe Glu Val Arg His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val 
        35                  40  


<210>  3
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


<210>  4
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  4

Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys 
1               5                   10              


<210>  5
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala 
1               5                   10                  15  


<210>  6
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  linker GS9, C5

<400>  6

Gly Gly Gly Gly Cys Gly Gly Gly Ser 
1               5                   


<210>  7
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  linker GS25, C5

<400>  7

Gly Gly Gly Gly Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  8
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  linker GS27, C14

<400>  8

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Cys Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25          


<210>  9
<211>  35
<212>  PRT
<213>  Artificial

<220>
<223>  linker GS35, C15

<400>  9

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Cys Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  10
<211>  35
<212>  PRT
<213>  Artificial

<220>
<223>  linker GS35, C5

<400>  10

Gly Gly Gly Gly Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  11
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  11

Thr Asp Thr Met Gly 
1               5   


<210>  12
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  12

Ala Val Thr Trp Asn Ser Gly Arg Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  13

His Arg Leu Val Val Gly Gly Thr Ser Val Gly Asp Trp Arg Tyr 
1               5                   10                  15  


<210>  14
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  14

Thr Asp Thr Met Gly 
1               5   


<210>  15
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  15

Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  16

His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg Tyr 
1               5                   10                  15  


<210>  17
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  17

Asn Tyr Asn Met Gly 
1               5   


<210>  18
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  18

Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  19
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  19

Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser Ser 
1               5                   10                  15  


<210>  20
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  FR1/1

<400>  20

Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg 
            20                  25                  


<210>  21
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  FR1/2

<400>  21

Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn 
            20                  25                  


<210>  22
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  FR2

<400>  22

Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ala 
1               5                   10                  


<210>  23
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  FR3/1

<400>  23

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  24
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  FR3/2

<400>  24

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  25
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  FR4

<400>  25

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  26
<211>  587
<212>  PRT
<213>  Artificial

<220>
<223>  Fc fusion protein

<400>  26

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
145                 150                 155                 160 


Thr Phe Asn Asn Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Arg Glu Phe Val Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        195                 200                 205             


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val 
225                 230                 235                 240 


Arg Arg Ser Tyr Ser Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                245                 250                 255     


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
            260                 265                 270         


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
        275                 280                 285             


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
    290                 295                 300                 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
305                 310                 315                 320 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
                325                 330                 335     


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
            340                 345                 350         


Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
        355                 360                 365             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    370                 375                 380                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
385                 390                 395                 400 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                405                 410                 415     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            420                 425                 430         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        435                 440                 445             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    450                 455                 460                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
465                 470                 475                 480 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
                485                 490                 495     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            500                 505                 510         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        515                 520                 525             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    530                 535                 540                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
545                 550                 555                 560 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                565                 570                 575     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585         


<210>  27
<211>  605
<212>  PRT
<213>  Artificial

<220>
<223>  Fc fusion protein

<400>  27

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Glu Val Gln Leu Leu Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val His Ser 
                165                 170                 175     


Gly Pro Thr Phe Arg Thr Asp Thr Met Gly Trp Phe Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Arg Glu Phe Val Ala Ala Val Thr Trp Asn Ser Gly Arg 
        195                 200                 205             


Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 


Asn Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Arg Phe Val Val Gly Gly 
                245                 250                 255     


Asn Arg Val Glu Asp Trp Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        275                 280                 285             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    290                 295                 300                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
305                 310                 315                 320 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                325                 330                 335     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            340                 345                 350         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        355                 360                 365             


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    370                 375                 380                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
385                 390                 395                 400 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                405                 410                 415     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            420                 425                 430         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        435                 440                 445             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    450                 455                 460                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
465                 470                 475                 480 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                485                 490                 495     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            500                 505                 510         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        515                 520                 525             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    530                 535                 540                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
545                 550                 555                 560 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                565                 570                 575     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            580                 585                 590         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        595                 600                 605 


<210>  28
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Fc fusion protein

<400>  28

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  29
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Fc fusion protein

<400>  29

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  30
<211>  605
<212>  PRT
<213>  Artificial

<220>
<223>  Fc fusion protein

<400>  30

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Glu Val Gln Leu Leu Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val His Ser 
                165                 170                 175     


Gly Pro Thr Phe Arg Thr Asp Thr Met Gly Trp Phe Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Arg Glu Phe Val Ala Ala Val Thr Trp Asn Ser Gly Arg 
        195                 200                 205             


Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 


Asn Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Arg Phe Val Val Gly Gly 
                245                 250                 255     


Asn Arg Val Glu Asp Trp Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        275                 280                 285             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    290                 295                 300                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
305                 310                 315                 320 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                325                 330                 335     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            340                 345                 350         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        355                 360                 365             


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    370                 375                 380                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
385                 390                 395                 400 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                405                 410                 415     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            420                 425                 430         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        435                 440                 445             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    450                 455                 460                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
465                 470                 475                 480 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                485                 490                 495     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            500                 505                 510         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        515                 520                 525             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    530                 535                 540                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
545                 550                 555                 560 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                565                 570                 575     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            580                 585                 590         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        595                 600                 605 


<210>  31
<211>  613
<212>  PRT
<213>  Artificial

<220>
<223>  Fc fusion protein

<400>  31

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Cys Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp Thr 
            180                 185                 190         


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ala 
        195                 200                 205             


Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                245                 250                 255     


Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg Tyr 
            260                 265                 270         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        275                 280                 285             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    290                 295                 300                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
305                 310                 315                 320 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                325                 330                 335     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            340                 345                 350         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        355                 360                 365             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    370                 375                 380                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
385                 390                 395                 400 


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                405                 410                 415     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            420                 425                 430         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        435                 440                 445             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    450                 455                 460                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
465                 470                 475                 480 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                485                 490                 495     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            500                 505                 510         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        515                 520                 525             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    530                 535                 540                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
545                 550                 555                 560 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                565                 570                 575     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            580                 585                 590         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        595                 600                 605             


Leu Ser Pro Gly Lys 
    610             


<210>  32
<211>  860
<212>  PRT
<213>  Artificial

<220>
<223>  HSA fusion protein

<400>  32

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Glu Val Gln Leu Leu Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val His Ser 
                165                 170                 175     


Gly Pro Thr Phe Arg Thr Asp Thr Met Gly Trp Phe Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Arg Glu Phe Val Ala Ala Val Thr Trp Asn Ser Gly Arg 
        195                 200                 205             


Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 


Asn Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Arg Phe Val Val Gly Gly 
                245                 250                 255     


Asn Arg Val Glu Asp Trp Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
        275                 280                 285             


Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
    290                 295                 300                 


Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
305                 310                 315                 320 


Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
                325                 330                 335     


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
            340                 345                 350         


Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
        355                 360                 365             


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
    370                 375                 380                 


Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
385                 390                 395                 400 


Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
                405                 410                 415     


Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
            420                 425                 430         


Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
        435                 440                 445             


Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
    450                 455                 460                 


Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
465                 470                 475                 480 


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
                485                 490                 495     


Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
            500                 505                 510         


Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
        515                 520                 525             


Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
    530                 535                 540                 


Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
545                 550                 555                 560 


Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
                565                 570                 575     


Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
            580                 585                 590         


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
        595                 600                 605             


Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
    610                 615                 620                 


Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
625                 630                 635                 640 


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
                645                 650                 655     


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
            660                 665                 670         


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
        675                 680                 685             


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
    690                 695                 700                 


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
705                 710                 715                 720 


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
                725                 730                 735     


Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
            740                 745                 750         


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
        755                 760                 765             


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
    770                 775                 780                 


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
785                 790                 795                 800 


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
                805                 810                 815     


Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
            820                 825                 830         


Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
        835                 840                 845             


Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
    850                 855                 860 


<210>  33
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  albumin binding protein

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  34
<211>  381
<212>  PRT
<213>  Artificial

<220>
<223>  ABII316

<400>  34

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        195                 200                 205             


Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr 
        275                 280                 285             


Asp Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe 
    290                 295                 300                 


Val Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser 
305                 310                 315                 320 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala 
                325                 330                 335     


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
            340                 345                 350         


Cys Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp 
        355                 360                 365             


Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380     


<210>  35
<211>  407
<212>  PRT
<213>  Artificial

<220>
<223>  ABII317

<400>  35

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp Thr 
            180                 185                 190         


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ala 
        195                 200                 205             


Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                245                 250                 255     


Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg Tyr 
            260                 265                 270         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    290                 295                 300                 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
305                 310                 315                 320 


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                325                 330                 335     


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
            340                 345                 350         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        355                 360                 365             


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
    370                 375                 380                 


Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
385                 390                 395                 400 


Thr Leu Val Thr Val Ser Ser 
                405         


<210>  36
<211>  381
<212>  PRT
<213>  Artificial

<220>
<223>  ABII318

<400>  36

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro 
145                 150                 155                 160 


Thr Phe Arg Thr Asp Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Arg Glu Phe Val Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        195                 200                 205             


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Ala His Arg Phe Val Val Gly Gly Asn Arg 
225                 230                 235                 240 


Val Glu Asp Trp Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
            260                 265                 270         


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
        275                 280                 285             


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
    290                 295                 300                 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
305                 310                 315                 320 


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                325                 330                 335     


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
            340                 345                 350         


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
        355                 360                 365             


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380     


<210>  37
<211>  407
<212>  PRT
<213>  Artificial

<220>
<223>  ABII319

<400>  37

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr Asn 
            180                 185                 190         


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ala 
        195                 200                 205             


Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                245                 250                 255     


Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser Ser 
            260                 265                 270         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    290                 295                 300                 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
305                 310                 315                 320 


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                325                 330                 335     


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
            340                 345                 350         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        355                 360                 365             


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
    370                 375                 380                 


Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
385                 390                 395                 400 


Thr Leu Val Thr Val Ser Ser 
                405         


<210>  38
<211>  381
<212>  PRT
<213>  Artificial

<220>
<223>  ABII320

<400>  38

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        195                 200                 205             


Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn 
        275                 280                 285             


Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe 
    290                 295                 300                 


Val Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser 
305                 310                 315                 320 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
                325                 330                 335     


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
            340                 345                 350         


Cys Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr 
        355                 360                 365             


Ser Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380     


<210>  39
<211>  380
<212>  PRT
<213>  Artificial

<220>
<223>  ABII321

<400>  39

Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp Thr 
            20                  25                  30          


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ala 
        35                  40                  45              


Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
        275                 280                 285             


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
    290                 295                 300                 


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
305                 310                 315                 320 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
                325                 330                 335     


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
            340                 345                 350         


Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser 
        355                 360                 365             


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380 


<210>  40
<211>  274
<212>  PRT
<213>  Artificial

<220>
<223>  ABII322; PEGylated at Cys 137

<400>  40

Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr Asn 
            20                  25                  30          


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ala 
        35                  40                  45              


Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Cys Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val His Ser Gly 
                165                 170                 175     


Pro Thr Phe Arg Thr Asp Thr Met Gly Trp Phe Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Gly Arg Glu Phe Val Ala Ala Val Thr Trp Asn Ser Gly Arg Ile 
        195                 200                 205             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Ala His Arg Phe Val Val Gly Gly Asn 
                245                 250                 255     


Arg Val Glu Asp Trp Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser 
        


<210>  41
<211>  282
<212>  PRT
<213>  Artificial

<220>
<223>  ABII323; PEGylated at Cys 138

<400>  41

Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr Asn 
            20                  25                  30          


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ala 
        35                  40                  45              


Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Cys Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
145                 150                 155                 160 


Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                165                 170                 175     


Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp Thr Met 
            180                 185                 190         


Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ala Ala 
        195                 200                 205             


Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val Lys Gly 
    210                 215                 220                 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr Leu Gln 
225                 230                 235                 240 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
                245                 250                 255     


His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg Tyr Trp 
            260                 265                 270         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280         


<210>  42
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  ABII305; PEGylated at Cys 129

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp Thr 
            180                 185                 190         


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
        195                 200                 205             


Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr Leu 
225                 230                 235                 240 


Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                245                 250                 255     


Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg Tyr 
            260                 265                 270         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        275                 280             


<210>  43
<211>  257
<212>  PRT
<213>  Artificial

<220>
<223>  ABII306; PEGylated at Cys 129

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Cys Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Leu Ala Gly Gly Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro 
145                 150                 155                 160 


Thr Phe Arg Thr Asp Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Glu Arg Glu Phe Val Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr 
        195                 200                 205             


Arg Asn Ala Ala Tyr Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Thr Ala His Arg Phe Val Val Gly Gly Asn Arg 
225                 230                 235                 240 


Val Glu Asp Trp Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                245                 250                 255     


Ser 
    


<210>  44
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII035

<400>  44

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  45
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII059

<400>  45

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  46
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  myc tag

<400>  46

Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala 
1               5                   10                  15      


Ala 
    


<210>  47
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABIIPMP42D4

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Ser Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Leu Val Val Gly Gly Thr Ser Val Gly Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  48
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABIIPMP111B4

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Trp Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Ser Ser Gly Arg Ala Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Gly Val Val Gly Gly Trp Val Val Val Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  49
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII111E5c11

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Leu Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Arg Glu Val Gln Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  50
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABIIPMP111C6

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Trp Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Leu Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Gln Val Val Gly Gly Val Gln Val Leu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  51
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABIIPMP111F2

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Ser Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Asn Arg His Ser Val Gly Arg Leu Ser Val Gly Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Ser Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  52
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABIIPMP111E4

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Ser Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Ala Arg Leu Thr Val Gly Ser Leu Ser Val Gly Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  53
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABIIPMP111C4

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Leu Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ala Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Ser Val Val Gly Gly Val Gly Val Trp Asp Trp Arg 
            100                 105                 110         


Tyr Trp Ser Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  54
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABIIPMP111B5

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Asn Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Leu Val Val Gly Gly Gly Gly Val Arg Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  55
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABIIPMP111B9

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Gly Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ala Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Gly Cys Val Lys Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  56
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII111B5_R30K

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Lys Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Met Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  57
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII111B5_R30W

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Trp Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Met Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  58
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII111B5_N106T

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Thr Met Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  59
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII111B5_N106V

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Val Met Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  60
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII111B5_F101W

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Trp Val Val Gly Gly Asn Met Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  61
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII111B5_M107E

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Glu Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  62
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII111B5_M107R = ABII002

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  63
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII111B5_E109W

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Met Val Trp Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  64
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII111B5_E109Q

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Met Val Gln Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  65
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII003

<400>  65

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  66
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII004

<400>  66

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  67
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII005

<400>  67

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  68
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII006

<400>  68

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  69
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII007

<400>  69

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  70
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII008

<400>  70

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  71
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII009

<400>  71

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Lys Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  72
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII010

<400>  72

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  73
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII011

<400>  73

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  74
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII012

<400>  74

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  75
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII013

<400>  75

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  76
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII014

<400>  76

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  77
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII015

<400>  77

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  78
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII016

<400>  78

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  79
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII017

<400>  79

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  80
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII018

<400>  80

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  81
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII019

<400>  81

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  82
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII020

<400>  82

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  83
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII021

<400>  83

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  84
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII022

<400>  84

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  85
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII023

<400>  85

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  86
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII024

<400>  86

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  87
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII025

<400>  87

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  88
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII026

<400>  88

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  89
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII027

<400>  89

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  90
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII028

<400>  90

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  91
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII029

<400>  91

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  92
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII030

<400>  92

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  93
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII031

<400>  93

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  94
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII032

<400>  94

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  95
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII033

<400>  95

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  96
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII034

<400>  96

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  97
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII035

<400>  97

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  98
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII036

<400>  98

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  99
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII037

<400>  99

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  100
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII60A10 = ABII050

<400>  100

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  101
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII051

<400>  101

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  102
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII052

<400>  102

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  103
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII053

<400>  103

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  104
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII054

<400>  104

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  105
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII055

<400>  105

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  106
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII056

<400>  106

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  107
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII057

<400>  107

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  108
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII058

<400>  108

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  109
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII059

<400>  109

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  110
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII060

<400>  110

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  111
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII061

<400>  111

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  112
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  ABII1E11

<400>  112

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asp Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe His Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Arg Ser Thr Tyr Tyr Thr Val Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Ser Ala Gly Arg Ala Ile Asn Leu Pro Leu Tyr Lys Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  113
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII14D4

<400>  113

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Asn Met Ala Trp Phe Arg His Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Ser Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Pro Arg Gly Arg Ser Ile Val Thr Thr Ala Thr Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  114
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  ABII5D2

<400>  114

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Ser Gln Ser Gly Gly Leu Arg Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Pro Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gln Ala Arg Ala Thr Ala Trp Ser Pro Gln Arg Val Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  115
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII35C7

<400>  115

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ile Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Ser Ser Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Ala Ala Arg Phe Gly Thr Pro Ile Asn Thr Arg Gly Ser Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  116
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII35D2

<400>  116

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Leu Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Leu Phe Gly Ser Ala Ile Asn Leu Leu Ser Glu Tyr Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  117
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII35G2

<400>  117

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Thr Thr Tyr Tyr Glu Asp Asp Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Pro Ser Tyr Val Ala Val Asn Ile Ala Ala Ser Tyr Asn 
            100                 105                 110         


Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  118
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII42D4

<400>  118

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Ser Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Thr Arg Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala His Arg Leu Val Val Gly Gly Thr Ser Val Gly Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  119
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII42B10

<400>  119

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Arg Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Leu 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Gln 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ser Pro Gly Gly Pro Ile Asn Tyr Gly Arg Ala Tyr Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  120
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII42F5

<400>  120

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Arg Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile Gly Trp Phe Cys Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ala Cys 
                85                  90                  95      


Ala Ala Ala Gln Arg Arg Leu Ala Val Asn Val Asp Thr Ser Tyr Asn 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  121
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII42E10

<400>  121

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Thr Leu Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ala Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Leu Ser Arg Asp Asn Ala Lys Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Glu Tyr Leu Cys 
                85                  90                  95      


Ala Ala Ala Phe Arg Gly Phe Ala Ile Asn Thr Pro Thr Ser Tyr Asn 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  122
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  ABII42G10

<400>  122

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Leu Phe Ser Gly Arg Thr Phe Ser Thr Asn 
            20                  25                  30          


Gly Val Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Ser Gly Ser Lys Thr Asn Tyr Ala Glu Pro Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Tyr Arg Thr Ser Ile Ser Arg Tyr Glu Tyr Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  123
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  ABII60A10

<400>  123

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  124
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  ABII60G11

<400>  124

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Glu Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Arg Ala Phe Ser Val Tyr 
            20                  25                  30          


Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Thr Phe Val Ala Ala 
        35                  40                  45              


Val Ala Trp Val Gly Gly Ser Thr Phe Tyr Ser Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe Leu His 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Arg Leu Tyr Gly Gly Arg Trp Tyr Asn Ser Pro Arg Val Asp Asp Phe 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  125
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  ABII60D2

<400>  125

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Tyr Ser Gly Ser Ile Phe Ser Ile Lys 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Gly Arg Ile Thr Ser Gly Asp Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Arg Pro Trp Pro Arg Ser Asp Val Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  126
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  ABII60H5

<400>  126

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Gly Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Thr Asn Ser Gly Ser Val Asn Tyr Gly Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Arg Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Ser Trp Gly Arg Ser Pro Leu Lys Tyr Leu Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  127
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  ABII61F6

<400>  127

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Val Asn Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ile Ile Asn Lys Arg Gly Val Thr Asn Tyr Ala Asp Ser Thr Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Arg Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Val Val Gly Arg Tyr Gly Arg Thr Tyr Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  128
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  3D6 VL

<400>  128

Tyr Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Ile Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  129
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  3D6 VH

<400>  129

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Asn Ser Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Arg Ser Gly Gly Gly Arg Thr Tyr Tyr Ser Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Tyr Asp His Tyr Ser Gly Ser Ser Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  130
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  m266 VL

<400>  130

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ile Tyr Ser 
            20                  25                  30          


Asp Gly Asn Ala Tyr Leu His Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Thr Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  131
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  m266 VH

<400>  131

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Gln Ile Asn Ser Val Gly Asn Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Tyr Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Arg Ser Asp Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


<210>  132
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  2D2

<400>  132

Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gly Thr Phe Ser Ser Ile 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Ala Ile Ser Arg Ser Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Arg Pro Ala Gly Thr Ala Ile Asn Ile Arg Arg Ser Tyr Asn 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  133
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  2G6

<400>  133

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Pro Arg Ala Ala Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Glu Pro Asp Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Leu Arg Tyr Arg Asp Arg Pro Gln Ser Ser Asp Phe Leu 
            100                 105                 110         


Phe Trp Arg Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  134
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  3A

<400>  134

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Asp Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Ser Gly Gly Ser Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ala Pro Thr Arg Trp Val Pro Arg Asp Ser Arg Phe Tyr Asp 
            100                 105                 110         


Arg Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser 
        115                 120                 


<210>  135
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  1B

<400>  135

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ser Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Tyr Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ile Arg Asp Trp Ala Thr Leu Arg Glu Tyr Glu Tyr Asp 
            100                 105                 110         


Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  136
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  11G

<400>  136

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Thr Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Asp Leu Val 
        35                  40                  45              


Ala Ala Ile Ile Ser Ser Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Ala Ile Arg Arg Ser Val Ile Asp Ala Trp Gly Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  137
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  4D

<400>  137

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Arg Trp Asn Gly Asp Tyr Ala Asp Ser Val Arg Asp Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Phe Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Arg 
                85                  90                  95      


Leu Gly Pro Arg Thr Ser Gln Ala Ala Leu Tyr Arg Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  138
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  8B

<400>  138

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Ser Gly Gly Ser Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ala Pro Thr Arg Trp Val Pro Arg Asp Ser Arg Phe Tyr Asp 
            100                 105                 110         


Arg Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser 
        115                 120                 


<210>  139
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  31-1

<400>  139

Ala Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Trp 
            20                  25                  30          


Ser Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Thr Ile Ser Gly Gly Gly Ser Ala Thr Thr Tyr Thr Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Arg Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Asp Val Ser Thr Gly Phe Arg Tyr Gln Arg Lys Asp Tyr 
            100                 105                 110         


Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  140
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  VH3-23 (DP-47)

<400>  140

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys 
        


<210>  141
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  9GS

<400>  141

Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   


<210>  142
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  ABII314, PEGylated at Cys 129

<400>  142

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp Thr 
            180                 185                 190         


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ala 
        195                 200                 205             


Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                245                 250                 255     


Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg Tyr 
            260                 265                 270         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280             


<210>  143
<211>  257
<212>  PRT
<213>  Artificial

<220>
<223>  ABII315, PEGylated at Cys 129

<400>  143

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Cys Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro 
145                 150                 155                 160 


Thr Phe Arg Thr Asp Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Arg Glu Phe Val Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        195                 200                 205             


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Ala His Arg Phe Val Val Gly Gly Asn Arg 
225                 230                 235                 240 


Val Glu Asp Trp Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                245                 250                 255     


Ser 
    


<210>  144
<211>  403
<212>  PRT
<213>  Artificial

<220>
<223>  His.Xa.Abeta1-28.GS

<400>  144

Met His His His His His His Ile Glu Gly Arg Asp Ala Glu Phe Arg 
1               5                   10                  15      


His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala 
            20                  25                  30          


Glu Asp Val Gly Ser Asn Lys Gly Gly Ser Gly Gly Ser Gln Glu Arg 
        35                  40                  45              


Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr Ile Trp Glu Val Pro 
    50                  55                  60                  


Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser Gly Ala Tyr Gly Ser 
65                  70                  75                  80  


Val Cys Ala Ala Phe Asp Thr Lys Thr Gly His Arg Val Ala Val Lys 
                85                  90                  95      


Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His Ala Lys Arg Thr Tyr 
            100                 105                 110         


Arg Glu Leu Arg Leu Leu Lys His Met Lys His Glu Asn Val Ile Gly 
        115                 120                 125             


Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu Glu Glu Phe Asn Asp 
    130                 135                 140                 


Val Tyr Leu Val Thr His Leu Met Gly Ala Asp Leu Asn Asn Ile Val 
145                 150                 155                 160 


Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln Phe Leu Ile Tyr Gln 
                165                 170                 175     


Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asp Ile Ile His Arg 
            180                 185                 190         


Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu Asp Cys Glu Leu Lys 
        195                 200                 205             


Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp Asp Glu Met Thr Gly 
    210                 215                 220                 


Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Trp 
225                 230                 235                 240 


Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser Val Gly Cys Ile Met 
                245                 250                 255     


Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro Gly Thr Asp His Ile 
            260                 265                 270         


Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly Thr Pro Gly Ala Glu 
        275                 280                 285             


Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg Asn Tyr Ile Gln Ser 
    290                 295                 300                 


Leu Ala Gln Met Pro Lys Met Asn Phe Ala Asn Val Phe Ile Gly Ala 
305                 310                 315                 320 


Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met Leu Val Leu Asp Ser 
                325                 330                 335     


Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala His Ala Tyr Phe Ala 
            340                 345                 350         


Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala Asp Pro Tyr Asp Gln 
        355                 360                 365             


Ser Phe Glu Ser Arg Asp Leu Leu Ile Asp Glu Trp Lys Ser Leu Thr 
    370                 375                 380                 


Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro Leu Asp Gln Glu Glu 
385                 390                 395                 400 


Met Glu Ser 
            


<210>  145
<211>  512
<212>  PRT
<213>  Artificial

<220>
<223>  ABII400

<400>  145

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Lys Ile Thr His Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Glu Arg Glu Phe Val Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe 
            180                 185                 190         


Tyr Ser Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        195                 200                 205             


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu 
225                 230                 235                 240 


Arg Val Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
        275                 280                 285             


Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
    290                 295                 300                 


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
305                 310                 315                 320 


Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                325                 330                 335     


Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
            340                 345                 350         


Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
        355                 360                 365             


Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
385                 390                 395                 400 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
                405                 410                 415     


Phe Asn Asn Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly 
            420                 425                 430         


Arg Glu Phe Val Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr 
        435                 440                 445             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    450                 455                 460                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
465                 470                 475                 480 


Val Tyr Tyr Cys Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg 
                485                 490                 495     


Arg Ser Tyr Ser Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 510         


<210>  146
<211>  515
<212>  PRT
<213>  Artificial

<220>
<223>  ABII401

<400>  146

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        195                 200                 205             


Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly 
            260                 265                 270         


Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Val Arg Thr Phe Ser Ile 
        275                 280                 285             


Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
    290                 295                 300                 


Val Ala Gly Ile Asn Arg Ser Gly Asp Val Thr Lys Tyr Ala Asp Phe 
305                 310                 315                 320 


Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Met Val 
                325                 330                 335     


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr 
            340                 345                 350         


Cys Ala Ala Thr Trp Ala Tyr Asp Thr Val Gly Ala Leu Thr Ser Gly 
        355                 360                 365             


Tyr Asn Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly 
385                 390                 395                 400 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                405                 410                 415     


Gly Arg Thr Phe Asn Asn Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro 
            420                 425                 430         


Gly Lys Gly Arg Glu Phe Val Ala Ala Val Ser Arg Ser Gly Val Ser 
        435                 440                 445             


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    450                 455                 460                 


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Tyr Arg Gly Thr Ala Ile 
                485                 490                 495     


Asn Val Arg Arg Ser Tyr Ser Ser Trp Gly Gln Gly Thr Leu Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  147
<211>  512
<212>  PRT
<213>  Artificial

<220>
<223>  ABII402

<400>  147

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        195                 200                 205             


Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn 
        275                 280                 285             


Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe 
    290                 295                 300                 


Val Ala Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser 
305                 310                 315                 320 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
                325                 330                 335     


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
            340                 345                 350         


Cys Ala Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr 
        355                 360                 365             


Ser Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Ala Ser Gly Gly Gly 
385                 390                 395                 400 


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                405                 410                 415     


Phe Lys Ile Thr His Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly 
            420                 425                 430         


Lys Glu Arg Glu Phe Val Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr 
        435                 440                 445             


Phe Tyr Ser Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    450                 455                 460                 


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
465                 470                 475                 480 


Thr Ala Asp Tyr Tyr Cys Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro 
                485                 490                 495     


Leu Arg Val Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
            500                 505                 510         


<210>  148
<211>  515
<212>  PRT
<213>  Artificial

<220>
<223>  ABII403

<400>  148

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Val Arg Thr Phe Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Arg Ser Gly Asp Val Thr Lys Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Trp Ala Tyr Asp Thr Val Gly Ala Leu Thr Ser Gly Tyr 
            100                 105                 110         


Asn Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val His Ser Gly 
145                 150                 155                 160 


Pro Thr Phe Arg Thr Asp Thr Met Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Arg Glu Phe Val Ala Ala Val Thr Trp Asn Ser Gly Arg Ile 
            180                 185                 190         


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala His Arg Phe Val Val Gly Gly Asn 
225                 230                 235                 240 


Arg Val Glu Asp Trp Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
            260                 265                 270         


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser 
        275                 280                 285             


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly 
305                 310                 315                 320 


Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                325                 330                 335     


Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser 
            340                 345                 350         


Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser 
        355                 360                 365             


Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly 
385                 390                 395                 400 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                405                 410                 415     


Gly Arg Thr Phe Asn Asn Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro 
            420                 425                 430         


Gly Lys Gly Arg Glu Phe Val Ala Ala Val Ser Arg Ser Gly Val Ser 
        435                 440                 445             


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    450                 455                 460                 


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Tyr Arg Gly Thr Ala Ile 
                485                 490                 495     


Asn Val Arg Arg Ser Tyr Ser Ser Trp Gly Gln Gly Thr Leu Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  149
<211>  541
<212>  PRT
<213>  Artificial

<220>
<223>  ABII404

<400>  149

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr Asn 
            180                 185                 190         


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ala 
        195                 200                 205             


Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                245                 250                 255     


Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser Ser 
            260                 265                 270         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    290                 295                 300                 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
305                 310                 315                 320 


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                325                 330                 335     


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
            340                 345                 350         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        355                 360                 365             


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
    370                 375                 380                 


Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
385                 390                 395                 400 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
                405                 410                 415     


Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
            420                 425                 430         


Ser Leu Arg Leu Ser Cys Ser Ala Ser Val Arg Thr Phe Ser Ile Tyr 
        435                 440                 445             


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
    450                 455                 460                 


Ala Gly Ile Asn Arg Ser Gly Asp Val Thr Lys Tyr Ala Asp Phe Val 
465                 470                 475                 480 


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr 
                485                 490                 495     


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
            500                 505                 510         


Ala Ala Thr Trp Ala Tyr Asp Thr Val Gly Ala Leu Thr Ser Gly Tyr 
        515                 520                 525             


Asn Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    530                 535                 540     


<210>  150
<211>  515
<212>  PRT
<213>  Artificial

<220>
<223>  ABII405

<400>  150

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Val Arg 
145                 150                 155                 160 


Thr Phe Ser Ile Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Glu Arg Glu Phe Val Ala Gly Ile Asn Arg Ser Gly Asp Val Thr Lys 
            180                 185                 190         


Tyr Ala Asp Phe Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala 
        195                 200                 205             


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
    210                 215                 220                 


Ala Leu Tyr Tyr Cys Ala Ala Thr Trp Ala Tyr Asp Thr Val Gly Ala 
225                 230                 235                 240 


Leu Thr Ser Gly Tyr Asn Phe Trp Gly Gln Gly Thr Gln Val Thr Val 
                245                 250                 255     


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu 
            260                 265                 270         


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
        275                 280                 285             


Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr Asn Met Gly Trp Phe 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ala Ala Val Ser Arg 
305                 310                 315                 320 


Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                325                 330                 335     


Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
            340                 345                 350         


Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Tyr Arg 
        355                 360                 365             


Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser Ser Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
385                 390                 395                 400 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
                405                 410                 415     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            420                 425                 430         


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        435                 440                 445             


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    450                 455                 460                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
465                 470                 475                 480 


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                485                 490                 495     


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210>  151
<211>  512
<212>  PRT
<213>  Artificial

<220>
<223>  ABII406

<400>  151

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe 
145                 150                 155                 160 


Arg Thr Asp Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg 
                165                 170                 175     


Glu Phe Val Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu 
225                 230                 235                 240 


Asp Trp Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
            260                 265                 270         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        275                 280                 285             


Ser Gly Arg Thr Phe Asn Asn Tyr Asn Met Gly Trp Phe Arg Gln Ala 
    290                 295                 300                 


Pro Gly Lys Gly Arg Glu Phe Val Ala Ala Val Ser Arg Ser Gly Val 
305                 310                 315                 320 


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                325                 330                 335     


Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro 
            340                 345                 350         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Tyr Arg Gly Thr Ala 
        355                 360                 365             


Ile Asn Val Arg Arg Ser Tyr Ser Ser Trp Gly Gln Gly Thr Leu Val 
    370                 375                 380                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
385                 390                 395                 400 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
                405                 410                 415     


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
            420                 425                 430         


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
        435                 440                 445             


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
                485                 490                 495     


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 510         


<210>  152
<211>  538
<212>  PRT
<213>  Artificial

<220>
<223>  ABII407

<400>  152

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Pro Thr Phe Arg Thr Asp 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Thr Trp Asn Ser Gly Arg Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Phe Val Val Gly Gly Asn Arg Val Glu Asp Trp Arg 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr Asn 
            180                 185                 190         


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val Ala 
        195                 200                 205             


Ala Val Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                245                 250                 255     


Ala Ala Tyr Arg Gly Thr Ala Ile Asn Val Arg Arg Ser Tyr Ser Ser 
            260                 265                 270         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Ser Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val 
    290                 295                 300                 


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys 
305                 310                 315                 320 


Ile Thr His Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
                325                 330                 335     


Arg Glu Phe Val Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr 
            340                 345                 350         


Ser Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        355                 360                 365             


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
    370                 375                 380                 


Asp Tyr Tyr Cys Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg 
385                 390                 395                 400 


Val Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            420                 425                 430         


Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        435                 440                 445             


Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
    450                 455                 460                 


Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp 
465                 470                 475                 480 


Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                485                 490                 495     


Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
            500                 505                 510         


Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser 
        515                 520                 525             


Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
    530                 535             


<210>  153
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  JH5

<400>  153

Asn Trp Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  15      


