                         SEQUENCE LISTING

<110>  Symphogen A/S
 
<120>  Anti-HER2 antibodies and compositions

<130>  P136PC00

<160>  116   

<170>  PatentIn version 3.5

<210>  1
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4517 VH coding sequence

<400>  1
gaagtgcagc tggtggaatc tggcggcgac ctggtgaaac ctggcggctc cctgaagctg       60

tcctgcgccg cctccggctt caccttctcc agctacggca tgtcctgggt gcgactgacc      120

cccgacaagc ggctggaatg ggtggcaacc atctccggcg gaggctccta cacctactac      180

cccgactccg tgaagggccg gttcaccatc tcccgggata tcgccaagtc caccctgtac      240

ctgcagatgt cctccctgaa gtccgaggac accgccgtgt actactgcgc ccggaagggc      300

aactacggca attacggcaa gctggcctac tggggccagg gcacctccgt gacagtctcg      360


<210>  2
<211>  120
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4517 VH

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Leu Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Asn Tyr Gly Asn Tyr Gly Lys Leu Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser 
        115                 120 


<210>  3
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4517 LC coding sequence

<400>  3
gatatccaga tgacccagtc ccccgcctcc ctgtccgtgt ctgtgggcga gacagtgacc       60

atcacctgtc gggcctccga gaacatctac tccaacctgg cctggtatca gcaggaacag      120

ggcaagtccc cccagctgct ggtgtacgcc gccaccaatc tggccgacgg cgtgccctcc      180

agattctccg gctctggctc cggcacccag tactccctga agatcaactc cctgcagtcc      240

gaggacttcg gctcctacta ctgccagcac ttctggggca ccccctggac cttcggcgga      300

ggcaccaagc tggaaatcaa gcggaccgtg gccgctccct ccgtgttcat cttcccaccc      360

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gtccttcaac cggggcgagt gc                         642


<210>  4
<211>  214
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4517 LC

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Glu Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  5
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4518 VH coding sequence

<400>  5
gaagtgcagc tgcagcagtc tggcgccgac ctggtgaaac ctggcgcctc cgtgaagctg       60

tcctgcacca cctccggctt caacatcaag gacatcttca tccactgggt gaaagagcgg      120

cccgagcagg gcctggaatg gatcggacgg atcgaccccg ccaacgacaa ccctaagtac      180

gaccccaagt tccagggcaa ggccaccatc tccgccgaca cctccagcaa caccgcctac      240

ctgcggctgt cctccctgac ctctgaggac accgccgtgt actactgcgc tggcggccct      300

gcctacttcg actattgggg ccagggcacc accctgacag tctcg                      345


<210>  6
<211>  115
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4518 VH

<400>  6

Glu Val Gln Leu Gln Gln Ser Gly Ala Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Thr Ser Gly Phe Asn Ile Lys Asp Ile 
            20                  25                  30          


Phe Ile His Trp Val Lys Glu Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Asp Asn Pro Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Pro Ala Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser 
        115 


<210>  7
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4518 LC coding sequence

<400>  7
gatatcgtga tgacccagtc ccacaagttc atgtccacct ccgtgggcga ccgggtgtcc       60

atctcctgca aggcctccca ggacgtgatc gccgccgtga cctggtatca gcagaagccc      120

ggccagtccc ccaagctgct gatctactgg gcctccaccc ggcacaccgg cgtgccagac      180

agattcaccg gctccggcag cggcaccgac tacaccctga ccatctccag catgcaggcc      240

gaggacctgg ccctgtacta ctgccagcag cactactcca ccccctggac cttcggcgga      300

ggcaccaagc tggaaatcaa gcggaccgtg gccgctccct ccgtgttcat cttcccaccc      360

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gtccttcaac cggggcgagt gc                         642


<210>  8
<211>  214
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4518 LC

<400>  8

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ser Cys Lys Ala Ser Gln Asp Val Ile Ala Ala 
            20                  25                  30          


Val Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Met Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  9
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4380/4381 VH coding sequence

<400>  9
caggtgcagc tgcagcagtc tggcgccgag ctggtgaaac ctggcgcctc cgtgaaggtg       60

tcctgcaccg cctccggcta caccttcacc aactactgga tccactgggt gaaacagcgg      120

cctggacagg gcctggaatg gatcggacgg atccacccct ccgactccga cgtgcactac      180

aaccagcggt tccgggacaa gaccaccctg accgtggacc ggtcctcctc caccgcctac      240

atgcagctgt cctccctgac ctccgaggac tccgccgtgt actactgcgc caagtcctac      300

tacgacagcg ccatggacta ctggggccag ggcacctccg tgaccgtctc g               351


<210>  10
<211>  117
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4380/4381 VH

<400>  10

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Thr Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Ser Asp Ser Asp Val His Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Arg Asp Lys Thr Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Tyr Tyr Asp Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser 
        115         


<210>  11
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4380/4381 LC coding sequence


<220>
<221>  misc_feature
<222>  (118)..(120)
<223>  nnn is acc or tat

<400>  11
gatatcgtgc tgacccagtc ccccgcctcc ctggctgtgt ctctgggcca gcgggccacc       60

atctcttgcc gggcctccaa gtccgtgacc acctccggct actcctacat gcactggnnn      120

cagcagaagc ccggccagcc ccccaagctg ctgatctccg tggcctccaa cctggaatcc      180

ggcgtgcccg ccagattctc cggctctggc tccggcaccg acttcaccct gaacatccac      240

cccgtggaag aagaggacgc cgccaccttc tactgccacc actccagaga gctgccctgg      300

accttcggcg gaggcaccaa gctggaaatc aagcggaccg tggccgctcc ctccgtgttc      360

atcttcccac cctccgacga gcagctgaag tccggcaccg cctccgtggt gtgcctgctg      420

aacaacttct acccccgcga ggccaaggtg cagtggaagg tggacaacgc cctgcagtcc      480

ggcaactccc aggaatccgt gaccgagcag gactccaagg acagcaccta ctccctgtcc      540

tccaccctga ccctgtccaa ggccgactac gagaagcaca aggtgtacgc ctgcgaagtg      600

acccaccagg gcctgtccag ccccgtgacc aagtccttca accggggcga gtgc            654


<210>  12
<211>  218
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4380/4381 LC

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa is Tyr or Thr

<400>  12

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Thr Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Xaa Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Ser Val Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Phe Tyr Cys His His Ser Arg 
                85                  90                  95      


Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  13
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4382 VH coding sequence

<400>  13
gaagtgcagc tgcagcagtc tggccccgag ctggtgaaac ctggcgcctc cgtgaagatc       60

tcctgcaccg cctccggcta caccttcacc gactactaca tgaactgggt gaaacagtcc      120

cacggaaagt ccctggaatg gatcggagac atcaacccca acaacggcgg caccaactac      180

aaccagaagt ggaagggcaa ggccaccctg accatccaca agtcctccag caccgcctac      240

atggaactgc ggtccctgac ctccgaggac tccgccgtgt acttctgtgt gcctggcggc      300

ctgcggtcct acttcgatta ctggggccag ggcaccaccc tgacagtctc g               351


<210>  14
<211>  117
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4382 VH

<400>  14

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Thr Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Trp 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ile His Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Pro Gly Gly Leu Arg Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser 
        115         


<210>  15
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4382 LC coding sequence

<400>  15
gacatcgtga tgacccagtc cctgaagttc atgtccgcct ccgtgggcga ccgggtgtcc       60

atcacatgca aggcctccca ggatgtgtct gccgccgtgg cctggtatca gcagaagcct      120

ggccagtccc ccgagctgct gatctactgg gcctctaccc ggcacaccgg cgtgcccgac      180

agattcaccg gctctggctc cggcaccgac tacaccctga ccatctccag cgtgcaggcc      240

gaggacctgg ccctgtacta ctgccagcag cactacacca ccccccccac cttcggcgga      300

ggcaccaagc tggaaatcaa gcggaccgtg gccgctccct ccgtgttcat cttcccaccc      360

tccgacgagc agctgaagtc cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gtccttcaac cggggcgagt gc                         642


<210>  16
<211>  214
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4382 LC

<400>  16

Asp Ile Val Met Thr Gln Ser Leu Lys Phe Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ala Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  17
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4383 VH coding sequence

<400>  17
cagatccagc tggtgcagtc tggccccgag cggaagaaac ccggcgagac agtgaagatc       60

tcctgcaagg cctccggcta caccttcacc gactactcca tccactgggt gaaacaggcc      120

cctggaaagg gcctgaagtg gatgggatgg atcaacaccg ccaccggcga gcctacccac      180

gtggacgact tcaagggcag attcgccttc tccctggaaa cctccgcctc caccgcctac      240

ctgcagatca ccaacctgaa gaacgaggat accgctacct acttctgcac cgcctgggcc      300

tacgagccct acttcgacta ctggggccag ggcaccaccc tgacagtctc g               351


<210>  18
<211>  117
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4383 VH

<400>  18

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Arg Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Ala Thr Gly Glu Pro Thr His Val Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Thr Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Thr Ala Trp Ala Tyr Glu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser 
        115         


<210>  19
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4383 LC coding sequence

<400>  19
gatatcgtga tgacccagtc ccacaagttc atgtccacct ccgtgggcga ccgggtgtcc       60

atcacatgca aggcctccca ggacgtgttc accgccgtgg cctggtatca gcagaagccc      120

ggccagtccc ccaagctgct gatctactcc gcctcctccc ggtacaccgg cgtgcccgac      180

agattcaccg gctctggctc cggcaccgac ttcatcttca ccatctccag cgtgcaggcc      240

gaggacctgg ccatctacca ctgccagcag cacttcggca tcccttggac cttcggcgga      300

ggcaccaagc tggaaatcaa gcggaccgtg gccgctccct ccgtgttcat cttcccaccc      360

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gtccttcaac cggggcgagt gc                         642


<210>  20
<211>  214
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4383 LC

<400>  20

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Phe Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Ile Tyr His Cys Gln Gln His Phe Gly Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  21
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4384 VH coding sequence

<400>  21
caggtgcagc tgcagcagcc tggcacagag ctggtgaaac ctggcgcctc cgtgaagctg       60

tcctgcaagg cctccggcta caccttcacc tcccactgga tgcactgggt gaaacagcgg      120

cctggacagg gcctggaatg gatcggcaac atcaacccct ccaacggcgg caccaactac      180

aacgagaagt tcaagtcccg ggccaccctg accgtggaca aggcctcctc caccgcctac      240

atgcagctgt cctccctgac ctccgaggac tccgccgtgt actactgcgc cagagcctac      300

tacgacttca gttggttcgt gtactggggc cagggcaccc tggtgacagt ctcg            354


<210>  22
<211>  118
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4384 VH

<400>  22

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Lys Ala Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Asp Phe Ser Trp Phe Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser 
        115             


<210>  23
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4384 LC coding sequence

<400>  23
gatatccaga tgacccagac ctcctccagc ctgtccgcct ccctgggcga cagagtgacc       60

atctcctgcc ggtcctccca ggacatctcc aactacctga actggtatca gcagaaaccc      120

gacggcaccg tgaagctgct gatgtacatc tcccggctgc actccggcgt gccctccaga      180

ttctccggct ctggctccgg caccgagtac tccctgacca tcagcaacct ggaacaggaa      240

gatatcgcta cctacttctg tcagcagggc aacaccctgc ccctgacctt cggcgctggc      300

accaagctgg aactgaagcg gaccgtggcc gctccctccg tgttcatctt cccaccctcc      360

gacgagcagc tgaagtccgg caccgcctcc gtggtgtgcc tgctgaacaa cttctacccc      420

cgcgaggcca aggtgcagtg gaaggtggac aacgccctgc agtccggcaa ctcccaggaa      480

tccgtgaccg agcaggactc caaggacagc acctactccc tgtcctccac cctgaccctg      540

tccaaggccg actacgagaa gcacaaggtg tacgcctgcg aagtgaccca ccagggcctg      600

tccagccccg tgaccaagtc cttcaaccgg ggcgagtgc                             639


<210>  24
<211>  213
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4384 LC

<400>  24

Asp Ile Gln Met Thr Gln Thr Ser Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ser Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Met 
        35                  40                  45              


Tyr Ile Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  25
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4385 VH coding sequence

<400>  25
caggtgacac tgaaagagtc tggcgccgag ctgatgaagc ctggcgcctc cgtgaagctg       60

tcctgcaagg ccaccggcta caccttcacc ggctactgga tcgagtgggt gaaacagcgg      120

cctggacacg gcctggaatg gatcggagag atcctgcctg gctccggctc caccaactac      180

aacgagaagt tcaagggcga ggccaccttt accgccgaca cctcctccaa caccgcctac      240

atgcacctgt cctccctgac caccgaggac tccgccatct actactgcgc cagatggggc      300

gacggctcct tcgcttattg gggccagggc accctggtga cagtctcg                   348


<210>  26
<211>  116
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4385 VH

<400>  26

Gln Val Thr Leu Lys Glu Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Glu Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Asp Gly Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  27
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4385 LC coding sequence

<400>  27
gatatcgtga tgacccagtc ccagaaattc atgtccacct ccgtgggcga ccgggtgtcc       60

atcacatgca aggcctccca gaacgtgggc accgccgtgt cctggtatca gcagaagccc      120

ggccagtccc ccaagctgct gatcttctcc acctccaacc ggtacaccgg cgtgcccgac      180

agattcaccg gctctggctc cggcaccgac ttcaccctga ccatctccaa catgcagtcc      240

gaggacctgg ccgactactt ctgccagcag taccggtcct accccttcac cttcggcagc      300

ggcaccaagc tggaaatcaa gcggaccgtg gccgctccct ccgtgttcat cttcccaccc      360

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gtccttcaac cggggcgagt gc                         642


<210>  28
<211>  214
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4385 LC

<400>  28

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ser Thr Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Arg Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  29
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4386 VH coding sequence

<400>  29
caggtgcagc tgcagcagcc tggagctgaa ctggtgaaac ctggcgcctc cgtgaaactg       60

tcctgcaagg cctccggcta caccttcacc agctactgga tgcactgggt gaaacagcgg      120

cctggacagg gcctggaatg gatcggcatg atccacccca actccggctc catcaactac      180

aacgagaagt tcaagaacaa ggccaccctg accgtggtga tctcctcctc caccgcctac      240

atgcagctgt cctccctgac ctccgaggac tccgccgtgt actactgcgc cggctacggc      300

aacggcccca tggattattg gggccagggc acctccgtga ccgtctcg                   348


<210>  30
<211>  116
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4386 VH

<400>  30

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Asn Ser Gly Ser Ile Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Val Ile Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Tyr Gly Asn Gly Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  31
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4386 LC coding sequence

<400>  31
cagatcgtgc tgacccagtc ccccgccatc atgtctgcca gccctggcga gaaagtgaca       60

atctcctgct ccgcctcctc cagcgtgtcc tacctgtact ggtatcagca gaagcccggc      120

tccagcccca agccctggat ctaccggacc tccaacctgg cctccggcgt gccagccaga      180

ttctccggct ccggcagcgg cacctcctac tccctgacca tctcctccat ggaagccgag      240

gacgccgcca cctactactg ccagcagtac cacaactacc ccctgacctt cggcgctggc      300

accaagctgg aactgaagcg gaccgtggcc gctccctccg tgttcatctt cccaccctcc      360

gacgagcagc tgaagtccgg caccgcctcc gtggtgtgcc tgctgaacaa cttctacccc      420

cgcgaggcca aggtgcagtg gaaggtggac aacgccctgc agtccggcaa ctcccaggaa      480

tccgtgaccg agcaggactc caaggacagc acctacagcc tgtcctccac cctgaccctg      540

tccaaggccg actacgagaa gcacaaggtg tacgcctgcg aagtgaccca ccagggcctg      600

tccagccccg tgaccaagtc cttcaaccgg ggcgagtgc                             639


<210>  32
<211>  213
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4386 LC

<400>  32

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Asn Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  33
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4387 VH coding sequence

<400>  33
caggtgcagc tgcagcagtc tggcgctgag ctggtgcgac ccggcacctc cgtgaagatg       60

tcctgcaagg cctccggcta caccttcacc aactactgga tcggctgggc caagcagcgg      120

cctggacacg gactggaatg gatcggagac atcctgcctg gcggcggata cacccactac      180

aacgagaagt tcaagggcaa ggccaccctg accgccgaca agtcctcctc caccgccttc      240

atgcagttct ccagcctgac ctccgaggac tccgccatct actactgcgc cagaggctcc      300

agcggctacc cctactactt cgactactgg ggccagggca ccaccctgac agtctcg         357


<210>  34
<211>  119
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4387 VH

<400>  34

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Ala Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Leu Pro Gly Gly Gly Tyr Thr His Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Ser Gly Tyr Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser 
        115                 


<210>  35
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4387 LC coding sequence

<400>  35
cagatcgtga tgacccagtc ccacaagttc atgtccacct ccgtgggcga ccgggtgtcc       60

atcacatgca aggcctccca ggacgtgggc accgccgtgg cctggtatca gcagaagccc      120

ggccagtccc ccaagctgct gatctactgg gcctccaccc ggcacaccgg cgtgccagac      180

agattcaccg gctccggcag cggcaccgac ttcaccctga ccatctccaa cgtgcagtcc      240

gaggacctgg ccgactactt ctgccagcag tactcctcct acccctacat gtacaccttc      300

ggcggaggca ccaagctgga aatcaagcgg accgtggccg ctccctccgt gttcatcttc      360

ccaccctccg acgagcagct gaagtccggc accgcctccg tggtgtgcct gctgaacaac      420

ttctaccccc gcgaggccaa ggtgcagtgg aaggtggaca acgccctgca gtccggcaac      480

tcccaggaat ccgtgaccga gcaggactcc aaggacagca cctactccct gtcctccacc      540

ctgaccctgt ccaaggccga ctacgagaag cacaaggtgt acgcctgcga agtgacccac      600

cagggcctgt ccagccccgt gaccaagtcc ttcaaccggg gcgagtgc                   648


<210>  36
<211>  216
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4387 LC

<400>  36

Gln Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr 
                85                  90                  95      


Met Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  37
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4519 VH coding sequence

<400>  37
gagatccagc tgcagcagtc tggccccgag ctggtgaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg cctccggcta ctccttcacc gactacaaca tctactgggt gaaacagtcc      120

cacggaaagt ccctggaatg gatcggatac atcgacccct acaacggcgg cacctcctac      180

aaccagaagt tcaagggcaa ggccaccctg accgtggaca agtcctcctc caccgccttc      240

atgcacctga actccctgac ctccgaggac tccgccgtgt actactgcgc cagaggcgct      300

ggctacgccc tggattattg gggccagggc acctccgtga cagtctcg                   348


<210>  38
<211>  116
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4519 VH

<400>  38

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  39
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 4519 LC coding sequence

<400>  39
cagatcgtgc tgacccagtc ccctgccctg atgtccgcct cccctggcga gaaagtgaca       60

atgacctgct ccgcctcctc ctccgtgtcc tacatgtact ggtatcagca gaagccccgg      120

tccagcccca agccctggat ctacctgacc tccaacctgg cctccggcgt gcccgccaga      180

ttctctggct ccggctccgg cacctcctac accctgacca tctccagcat ggaagccgag      240

gacgccgcca cctactactg ccagcagtgg tcctccaccc cctacacctt cggcggaggc      300

accaagctgg aactgaagcg gaccgtggcc gctccctccg tgttcatctt cccaccctcc      360

gacgagcagc tgaagtccgg caccgcctcc gtggtgtgcc tgctgaacaa cttctacccc      420

cgcgaggcca aggtgcagtg gaaggtggac aacgccctgc agtccggcaa ctcccaggaa      480

tccgtgaccg agcaggactc caaggacagc acctactccc tgtccagcac cctgaccctg      540

tccaaggccg actacgagaa gcacaaggtg tacgcctgcg aagtgaccca ccagggcctg      600

tccagccctg tgaccaagtc cttcaaccgg ggcgagtgc                             639


<210>  40
<211>  213
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Ab 4519 LC

<400>  40

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Thr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  41
<211>  320
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Ig kappa DNA

<220>
<221>  exon
<222>  (3)..(320)

<400>  41
ga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag          47
   Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu            
   1               5                   10                  15             

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc         95
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
                20                  25                  30                

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        143
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
            35                  40                  45                    

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        191
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
        50                  55                  60                        

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        239
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
    65                  70                  75                            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        287
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
80                  85                  90                  95            

ccc gtc aca aag agc ttc aac agg gga gag tgt                            320
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
                100                 105                                   


<210>  42
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Ig kappa constant region

<400>  42

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  43
<211>  1602
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human IGHG1 constant domain genomic sequence

<220>
<221>  exon
<222>  (1)..(298)

<220>
<221>  exon
<222>  (690)..(734)

<220>
<221>  exon
<222>  (853)..(1182)

<220>
<221>  exon
<222>  (1280)..(1602)

<400>  43
agt gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc         48
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser           
1               5                   10                  15                

aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac         96
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp           
            20                  25                  30                    

tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc        144
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr           
        35                  40                  45                        

agc ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac        192
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr           
    50                  55                  60                            

tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag        240
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln           
65                  70                  75                  80            

acc tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac        288
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp           
                85                  90                  95                

aag aga gtt g gtgagaggcc agcacaggga gggagggtgt ctgctggaag              338
Lys Arg Val                                                               
                                                                          

ccaggctcag cgctcctgcc tggacgcatc ccggctatgc agtcccagtc cagggcagca      398

aggcaggccc cgtctgcctc ttcacccgga ggcctctgcc cgccccactc atgctcaggg      458

agagggtctt ctggcttttt ccccaggctc tgggcaggca caggctaggt gcccctaacc      518

caggccctgc acacaaaggg gcaggtgctg ggctcagacc tgccaagagc catatccggg      578

aggaccctgc ccctgaccta agcccacccc aaaggccaaa ctctccactc cctcagctcg      638

gacaccttct ctcctcccag attccagtaa ctcccaatct tctctctgca g ag  ccc       694
                                                         Glu Pro          
                                                                          

aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca g gtaagccagc       744
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro                       
            105                 110                                       

ccaggcctcg ccctccagct caaggcggga caggtgccct agagtagcct gcatccaggg      804

acaggcccca gccgggtgct gacacgtcca cctccatctc ttcctcag ca  cct gaa       860
                                                     Ala Pro Glu          
                                                                          

ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac        908
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
        120                 125                 130                       

acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac        956
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
    135                 140                 145                           

gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc       1004
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly           
150                 155                 160                 165           

gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac       1052
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn           
                170                 175                 180               

agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg       1100
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp           
            185                 190                 195                   

ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca       1148
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro           
        200                 205                 210                       

gcc ccc atc gag aaa acc atc tcc aaa gcc aaa g gtgggacccg              1192
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys                               
    215                 220                                               

tggggtgcga gggccacatg gacagaggcc ggctcggccc accctctgcc ctgagagtga     1252

ccgctgtacc aacctctgtc cctacag gg  cag ccc cga gaa cca cag gtg tac     1305
                              Gly Gln Pro Arg Glu Pro Gln Val Tyr         
                                                  230                     

acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg       1353
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu           
    235                 240                 245                           

acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg       1401
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp           
250                 255                 260                 265           

gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg       1449
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val           
                270                 275                 280               

ctg gac tcc gac ggc tcc ttc ttc ctc tat agc aag ctc acc gtg gac       1497
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp           
            285                 290                 295                   

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat       1545
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His           
        300                 305                 310                       

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tcc ccg       1593
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro           
    315                 320                 325                           

ggt aaa tga                                                           1602
Gly Lys                                                                   
330                                                                       


<210>  44
<211>  331
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human IGHG1 constant region

<400>  44

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
1               5                   10                  15      


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            20                  25                  30          


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        35                  40                  45              


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
65                  70                  75                  80  


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                85                  90                  95      


Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            100                 105                 110         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        115                 120                 125             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    130                 135                 140                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
145                 150                 155                 160 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                165                 170                 175     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            180                 185                 190         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        195                 200                 205             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    210                 215                 220                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
225                 230                 235                 240 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                245                 250                 255     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            260                 265                 270         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    290                 295                 300                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
305                 310                 315                 320 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330     


<210>  45
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4517 HCDR1

<400>  45

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4517 HCDR2

<400>  46

Ile Ser Gly Gly Gly Ser Tyr Thr 
1               5               


<210>  47
<211>  16
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4517 HCDR3

<400>  47

Cys Ala Arg Lys Gly Asn Tyr Gly Asn Tyr Gly Lys Leu Ala Tyr Trp 
1               5                   10                  15      


<210>  48
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4518 HCDR1

<400>  48

Gly Phe Asn Ile Lys Asp Ile Phe 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4518 HCDR2

<400>  49

Ile Asp Pro Ala Asn Asp Asn Pro 
1               5               


<210>  50
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4518 HCDR3

<400>  50

Cys Ala Gly Gly Pro Ala Tyr Phe Asp Tyr Trp 
1               5                   10      


<210>  51
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4380/4381 HCDR1

<400>  51

Gly Tyr Thr Phe Thr Asn Tyr Trp 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4380/4381 HCDR2

<400>  52

Ile His Pro Ser Asp Ser Asp Val 
1               5               


<210>  53
<211>  13
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4380/4381 HCDR3

<400>  53

Cys Ala Lys Ser Tyr Tyr Asp Ser Ala Met Asp Tyr Trp 
1               5                   10              


<210>  54
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4382 HCDR1

<400>  54

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4382 HCDR2

<400>  55

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  56
<211>  13
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4382 HCDR3

<400>  56

Cys Val Pro Gly Gly Leu Arg Ser Tyr Phe Asp Tyr Trp 
1               5                   10              


<210>  57
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4383 HCDR1

<400>  57

Gly Tyr Thr Phe Thr Asp Tyr Ser 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4383 HCDR2

<400>  58

Ile Asn Thr Ala Thr Gly Glu Pro 
1               5               


<210>  59
<211>  13
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4383 HCDR3

<400>  59

Cys Thr Ala Trp Ala Tyr Glu Pro Tyr Phe Asp Tyr Trp 
1               5                   10              


<210>  60
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4384 HCDR1

<400>  60

Gly Tyr Thr Phe Thr Ser His Trp 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4384 HCDR2

<400>  61

Ile Asn Pro Ser Asn Gly Gly Thr 
1               5               


<210>  62
<211>  14
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4384 HCDR3

<400>  62

Cys Ala Arg Ala Tyr Tyr Asp Phe Ser Trp Phe Val Tyr Trp 
1               5                   10                  


<210>  63
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4385 HCDR1

<400>  63

Gly Tyr Thr Phe Thr Gly Tyr Trp 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4385 HCDR2

<400>  64

Ile Leu Pro Gly Ser Gly Ser Thr 
1               5               


<210>  65
<211>  12
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4385 HCDR3

<400>  65

Cys Ala Arg Trp Gly Asp Gly Ser Phe Ala Tyr Trp 
1               5                   10          


<210>  66
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4386 HCDR1

<400>  66

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4386 HCDR2

<400>  67

Ile His Pro Asn Ser Gly Ser Ile 
1               5               


<210>  68
<211>  12
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4386 HCDR3

<400>  68

Cys Ala Gly Tyr Gly Asn Gly Pro Met Asp Tyr Trp 
1               5                   10          


<210>  69
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4387 HCDR1

<400>  69

Gly Tyr Thr Phe Thr Asn Tyr Trp 
1               5               


<210>  70
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4387 HCDR2

<400>  70

Ile Leu Pro Gly Gly Gly Tyr Thr 
1               5               


<210>  71
<211>  15
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4387 HCDR3

<400>  71

Cys Ala Arg Gly Ser Ser Gly Tyr Pro Tyr Tyr Phe Asp Tyr Trp 
1               5                   10                  15  


<210>  72
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4519 HCDR1

<400>  72

Gly Tyr Ser Phe Thr Asp Tyr Asn 
1               5               


<210>  73
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4519 HCDR2

<400>  73

Ile Asp Pro Tyr Asn Gly Gly Thr 
1               5               


<210>  74
<211>  12
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4519 HCDR3

<400>  74

Cys Ala Arg Gly Ala Gly Tyr Ala Leu Asp Tyr Trp 
1               5                   10          


<210>  75
<211>  6
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4517 LCDR1

<400>  75

Glu Asn Ile Tyr Ser Asn 
1               5       


<210>  76
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4517 LCDR3

<400>  76

Cys Gln His Phe Trp Gly Thr Pro Trp Thr Phe 
1               5                   10      


<210>  77
<211>  6
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4518 LCDR1

<400>  77

Gln Asp Val Ile Ala Ala 
1               5       


<210>  78
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4518 LCDR3

<400>  78

Cys Gln Gln His Tyr Ser Thr Pro Trp Thr Phe 
1               5                   10      


<210>  79
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4380/4381 LCDR1

<400>  79

Lys Ser Val Thr Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  80
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4380/4381 LCDR3

<400>  80

Cys His His Ser Arg Glu Leu Pro Trp Thr Phe 
1               5                   10      


<210>  81
<211>  6
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4382 LCDR1

<400>  81

Gln Asp Val Ser Ala Ala 
1               5       


<210>  82
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4382 LCDR3

<400>  82

Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe 
1               5                   10      


<210>  83
<211>  6
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4383 LCDR1

<400>  83

Gln Asp Val Phe Thr Ala 
1               5       


<210>  84
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4383 LCDR3

<400>  84

Cys Gln Gln His Phe Gly Ile Pro Trp Thr Phe 
1               5                   10      


<210>  85
<211>  6
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4384 LCDR1

<400>  85

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  86
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4384 LCDR3

<400>  86

Cys Gln Gln Gly Asn Thr Leu Pro Leu Thr Phe 
1               5                   10      


<210>  87
<211>  6
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4385 LCDR1

<400>  87

Gln Asn Val Gly Thr Ala 
1               5       


<210>  88
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4385 LCDR3

<400>  88

Cys Gln Gln Tyr Arg Ser Tyr Pro Phe Thr Phe 
1               5                   10      


<210>  89
<211>  5
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4386 + Ab 4519 LCDR1

<400>  89

Ser Ser Val Ser Tyr 
1               5   


<210>  90
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4386 LCDR3

<400>  90

Cys Gln Gln Tyr His Asn Tyr Pro Leu Thr Phe 
1               5                   10      


<210>  91
<211>  6
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4387 LCDR1

<400>  91

Gln Asp Val Gly Thr Ala 
1               5       


<210>  92
<211>  13
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4387 LCDR3

<400>  92

Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr Met Tyr Thr Phe 
1               5                   10              


<210>  93
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Ab 4519 LCDR3

<400>  93

Cys Gln Gln Trp Ser Ser Thr Pro Tyr Thr Phe 
1               5                   10      


<210>  94
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  94
gacsgatggg cccttggtgg                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  95
gctgtaggtg ctgtctttgc                                                   20


<210>  96
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  96
tattcccatg gcgcgccsag gtccarctgc arcagyctg                              39


<210>  97
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  97
tattcccatg gcgcgccgar gtgmagctkg tkgagtc                                37


<210>  98
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  98
tattcccatg gcgcgccsag gtgcagctkm aggagtc                                37


<210>  99
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  99
tattcccatg gcgcgcccag gttactctga aagagtc                                37


<210>  100
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  100
tattcccatg gcgcgcccag atccagttgg tgcagtctg                              39


<210>  101
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  101
ggcgcgccat gggaatagct agccgayatc cagatgachc arwct                       45


<210>  102
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  102
ggcgcgccat gggaatagct agccracatt gtgmtgachc agtc                        44


<210>  103
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  103
ggcgcgccat gggaatagct agccsamatt gtkctsaccc artctc                      46


<210>  104
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  104
ggcgcgccat gggaatagct agccgatrtt gtgatgacbc arrct                       45


<210>  105
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  105
ggacagggmt ccakagttcc adkt                                              24


<210>  106
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  106
gacagatggt gcagccacag ttcgtttgat ttccagcttg gtg                         43


<210>  107
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  107
gacagatggt gcagccacag ttcgttttat ttccagcttg gtc                         43


<210>  108
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  108
gacagatggt gcagccacag ttcgttttat ttccaacttt gtc                         43


<210>  109
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  109
gacagatggt gcagccacag ttcgtttcag ctccagcttg gtc                         43


<210>  110
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  110
gaactgtggc tgcaccatct gtc                                               23


<210>  111
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  111
accgcctcca ccggcggccg cttattaaca ctctcccctg ttg                         43


<210>  112
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  112
accgcctcca ccggcggccg cttattaaca ctctcccctg ttgaagctct t                51


<210>  113
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  113
ggaggcgctc gagacggtga ccgtggtccc                                        30


<210>  114
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  114
ggaggcgctc gagactgtga gagtggtgcc                                        30


<210>  115
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  115
ggaggcgctc gagacagtga ccagagtccc                                        30


<210>  116
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  116
ggaggcgctc gagacggtga ctgaggttcc                                        30


