                         SEQUENCE LISTING

<110>  SOMALOGIC, INC.
 
<120>  APTAMERS TO 4-1BB AND THEIR USE IN TREATING DISEASES AND 
       DISORDERS

<130>  0057.29/PCT

<150>  61/310,230
<151>  2010-03-03

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (17)..(56)
<223>  n is a, c, g, or t

<400>  1
ccgtcctcct ctccgtnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnggga       60

cactgggtgc agg                                                          73


<210>  2
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
atatatatcc tgcacccagt gtccc                                             25


<210>  3
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
ttttttttcc gtcctcctct ccgtc                                             25


<210>  4
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (44)..(46)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  5-tryptaminocarboxamide modified T

<400>  4
cctgcaccca gtgtcccgga ngnannnnnn annnangnag nggnnnnnna gggnnnggan       60

ggagaggagg angg                                                         74


<210>  5
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (53)..(55)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  5-methyl C

<400>  5
cctgcaccca gtgtcccnng nannnnnnag nanannnnga ngnggangna nannngggan       60

ggagaggagg angg                                                         74


<210>  6
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (26)..(28)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  5-methyl C

<400>  6
cctgcaccca gtgtcccnga nggggnnnnn nagnngnann nngnaanggn ggangnngan       60

ggagaggagg angg                                                         74


<210>  7
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  5-methyl C

<400>  7
cctgcaccca gtgtcccnnn ngnnnnnnag nnngnggang nggggngang agangnggan       60

ggagaggagg angg                                                         74


<210>  8
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  5-methyl C

<400>  8
cctgcaccca gtgtcccgga ngnanggnng anagganana anganangnn nnnnagggan       60

ggagaggagg angg                                                         74


<210>  9
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-trytaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-trytaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  5-trytaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  5-trytaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (36)..(38)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  5-trytaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  5-trytaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  5-trytaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (55)..(56)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  5-methyl C

<400>  9
cctgcaccca gtgtcccgga ngngngngag nngnnnnnnn naggaanang nngannggan       60

ggagaggagg angg                                                         74


<210>  10
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (25)..(27)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  5-methyl C

<400>  10
cctgcaccca gtgtcccgan ggggnnnnnn agnngnannn ngnaanggng gangnngang       60

gagaggagga ngg                                                          73


<210>  11
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (43)..(44)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (46)..(48)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (54)..(55)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  5-methyl C

<400>  11
cctgcaccca gtgtcccgnn nnaggnggan gnngaaagaa gnnnannnnn nagnnnagan       60

ggagaggagg angg                                                         74


<210>  12
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (25)..(27)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (35)..(37)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  5-methyl C

<400>  12
cctgcaccca gtgtcccggn nnngnnnnnn agngnnngna nngngnggan gnnangngan       60

ggagaggagg angg                                                         74


<210>  13
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (37)..(39)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (53)..(54)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  5-tryptaminocarboxamide modified T

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  5-methyl C

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  5-methyl C

<400>  13
cctgcaccca gtgtcccnng nggangngan nnggngnnnn nnagnnggan gannngggan       60

ggagaggagg angg                                                         74


