                         SEQUENCE LISTING

<110>  UCB Pharma S.A.
       Tyson, Kelly Louise
 
<120>  PD1-Antibody

<130>  G0132-WO01

<140>  61/312,754
<141>  2010-03-11

<160>  36   

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 

<400>  1

Gly Tyr Ser Ile Thr Ser Asp Tyr Ala Trp Asn 
1               5                   10      


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2
<400>  2

Tyr Ile Asn Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  3

Trp Ile Gly Ser Ser Ala Trp Tyr Phe Asp Val 
1               5                   10      


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  4

Arg Ser Gly Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  5

Lys Val Ser Asn Arg Phe Phe 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  6

Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   


<210>  7
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Ab 948 VL region 

<400>  7

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Gly Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Phe Gly Val Pro 
    50                  55                  60                  


Asp Arg Ile Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  8
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Ab 948 VL region 

<400>  8

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Gly Gln Asn Ile 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Phe 
65                  70                  75                  80  


Gly Val Pro Asp Arg Ile Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  9
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Ab 948 VL region with signal sequence 

<400>  9

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Asn Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ile Gly Ser Ser Ala Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser 
        115                 


<210>  10
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Ab 948 VL region with signal sequence 

<400>  10

Met Arg Val Leu Ile Leu Leu Trp Leu Phe Thr Ala Phe Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Asn Tyr Ser Gly Ser Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Trp Ile Gly Ser Ser Ala Trp Tyr Phe Asp Val Trp 
        115                 120                 125             


Gly Ala Gly Thr Thr Val Thr Val Ser 
    130                 135         


<210>  11
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Ab 948 VH region 

<400>  11

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Gly Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Phe Gly Val Pro 
    50                  55                  60                  


Asp Arg Ile Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  12
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Ab 948 VH region  

<400>  12

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Gly Gln Asn 
        35                  40                  45              


Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Phe Gly Val Pro Asp Arg Ile Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe 
            100                 105                 110         


Cys Phe Gln Gly Ser His Val Pro Phe Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys 
    130         


<210>  13
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Ab 948 VH region with signal sequence 

<400>  13

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Gly Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Phe Gly Val Pro 
    50                  55                  60                  


Asp Arg Ile Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  14
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Ab 948 VH region with signal sequence 

<400>  14

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Gly Gln Asn 
        35                  40                  45              


Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Phe Gly Val Pro Asp Arg Ile Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe 
            100                 105                 110         


Cys Phe Gln Gly Ser His Val Pro Phe Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  15
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  g948.g1 VL 

<400>  15

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Asn Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ile Gly Ser Ser Ala Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser 
        115                 


<210>  16
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  948.g1 VL 

<400>  16

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Lys 
    50                  55                  60                  


Leu Glu Trp Met Gly Tyr Ile Asn Tyr Ser Gly Ser Thr Ser Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Trp Ile Gly Ser Ser Ala Trp Tyr Phe Asp Val 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135             


<210>  17
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  948.g1 VL 

<400>  17

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Asn Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ile Gly Ser Ser Ala Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  18
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  948.g1 VL 

<400>  18

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Lys 
    50                  55                  60                  


Leu Glu Trp Met Gly Tyr Ile Asn Tyr Ser Gly Ser Thr Ser Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Trp Ile Gly Ser Ser Ala Trp Tyr Phe Asp Val 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
    210                 215                 220                 


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
225                 230                 235                 240 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 


Gly Lys 
465     


<210>  19
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  948.g1 light chain (V + constant)  

<400>  19

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Ser Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ile His Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  20
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  948.g1 light chain (V + constant) 

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser 
    


<210>  21
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  948.g1 light chain 

<400>  21
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctggtca gaacattgta catagtaatg gaaacaccta tttagaatgg      120

tacctacaga aaccaggcca gtctccaaag ctcctgatct acaaagtctc caaccgattt      180

tttggggtcc cagacaggat cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ttcaaggttc acatgttcca      300

ttcacgttcg gctcggggac aaagctggaa ataaaa                                336


<210>  22
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  948.g1 light with signal sequence

<400>  22
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctggtcagaa cattgtacat agtaatggaa acacctattt agaatggtac      180

ctacagaaac caggccagtc tccaaagctc ctgatctaca aagtctccaa ccgatttttt      240

ggggtcccag acaggatcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat ttctgctttc aaggttcaca tgttccattc      360

acgttcggct cggggacaaa gctggaaata aaa                                   393


<210>  23
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  948.g1 VH 

<400>  23
gatgtgcagc ttcaggagtc gggacctggc ctggtgaaac cttctcagtc tctgtccctc       60

acctgcactg tcactggcta ctcaatcacc agtgattatg cctggaactg gatccggcag      120

tttccaggaa acaaactgga gtggatgggc tacataaact acagtggtag cactagctac      180

aacccatctc tcaaaagtcg aatctctatc acccgagaca catccaagaa ccagttcttc      240

ctgcagttga attctgtgac tactgaggac acagccacat attactgtgc aagatggatc      300

ggtagtagcg cctggtactt cgatgtctgg ggcgcaggga ccacggtcac agtctcg         357


<210>  24
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>  948.g1 VH 

<400>  24
atgagagtgc tgattctttt gtggctgttc acagcctttc ctggtatcct gtctgatgtg       60

cagcttcagg agtcgggacc tggcctggtg aaaccttctc agtctctgtc cctcacctgc      120

actgtcactg gctactcaat caccagtgat tatgcctgga actggatccg gcagtttcca      180

ggaaacaaac tggagtggat gggctacata aactacagtg gtagcactag ctacaaccca      240

tctctcaaaa gtcgaatctc tatcacccga gacacatcca agaaccagtt cttcctgcag      300

ttgaattctg tgactactga ggacacagcc acatattact gtgcaagatg gatcggtagt      360

agcgcctggt acttcgatgt ctggggcgca gggaccacgg tcacagtctc g               411


<210>  25
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  948.g1 VH 

<400>  25
gacgtgctga tgacccagac acccctgtca cttagcgtga ctcctggcca acctgcctca       60

atttcctgtc gctccggtca gaatatcgtg cactctaacg ggaacaccta cttggagtgg      120

tatctccaaa agcctggcca gagcccaaag ctgctgatct acaaggtctc caatcggttc      180

tttggcgtgc ctgacagaat tagtggtagc ggatccggaa ctgacttcac cctgaaaatc      240

tcacgggtgg aagctgaaga tgtcggcgtg tatttctgct tccaaggctc ccacgttccc      300

tttacgtttg gacagggcac caaactggag ataaag                                336


<210>  26
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  948.g1 VH with signal sequence

<400>  26
atgagcgtcc caacacaagt tcttgggctc cttctgctct ggcttactga tgcaagatgc       60

gacgtgctga tgacccagac acccctgtca cttagcgtga ctcctggcca acctgcctca      120

atttcctgtc gctccggtca gaatatcgtg cactctaacg ggaacaccta cttggagtgg      180

tatctccaaa agcctggcca gagcccaaag ctgctgatct acaaggtctc caatcggttc      240

tttggcgtgc ctgacagaat tagtggtagc ggatccggaa ctgacttcac cctgaaaatc      300

tcacgggtgg aagctgaaga tgtcggcgtg tatttctgct tccaaggctc ccacgttccc      360

tttacgtttg gacagggcac caaactggag ataaag                                396


<210>  27
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  948.g1 heavy chain (V + constant  hu IgG4P)  

<400>  27
gacgtgctga tgacccagac acccctgtca cttagcgtga ctcctggcca acctgcctca       60

atttcctgtc gctccggtca gaatatcgtg cactctaacg ggaacaccta cttggagtgg      120

tatctccaaa agcctggcca gagcccaaag ctgctgatct acaaggtctc caatcggttc      180

tttggcgtgc ctgacagaat tagtggtagc ggatccggaa ctgacttcac cctgaaaatc      240

tcacgggtgg aagctgaaga tgtcggcgtg tatttctgct tccaaggctc ccacgttccc      300

tttacgtttg gacagggcac caaactggag ataaagcgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  28
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223> 948.g1 heavy chain (V + constant  hu IgG4P)  

<400>  28
atgagcgtcc caacacaagt tcttgggctc cttctgctct ggcttactga tgcaagatgc       60

gacgtgctga tgacccagac acccctgtca cttagcgtga ctcctggcca acctgcctca      120

atttcctgtc gctccggtca gaatatcgtg cactctaacg ggaacaccta cttggagtgg      180

tatctccaaa agcctggcca gagcccaaag ctgctgatct acaaggtctc caatcggttc      240

tttggcgtgc ctgacagaat tagtggtagc ggatccggaa ctgacttcac cctgaaaatc      300

tcacgggtgg aagctgaaga tgtcggcgtg tatttctgct tccaaggctc ccacgttccc      360

tttacgtttg gacagggcac caaactggag ataaagcgta cggtagcggc cccatctgtc      420

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      480

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      540

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      600

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      660

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         717


<210>  29
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  948.g1 heavy chain (V + constant  hu IgG4P) 

<400>  29
gaagttcagc tgcaagaatc cggccctgga ctcgtgaaac caagccagac actgagcctg       60

acttgcaccg tcactggcta tagcatcacc agcgattacg cctggaactg gataaggcag      120

ccacctggaa agaagctgga gtggatgggc tacatcaact actccggaag cacgtcctac      180

aatccctcac ttaagagcag agtcacaatc tcacgagaca cctccaagaa ccagttctcc      240

ctgaaactga gctccgttac tgccgctgat actgccgtgt actattgtgc aaggtggatt      300

gggagctcag cttggtattt cgacgtttgg ggacaaggca cacttgtgac cgtctcg         357


<210>  30
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  948.g1 heavy chain (V + constant  hu IgG4P

<400>  30
atggagtgga gctgggtctt tctcttcttt ctctccgtga ctaccggtgt gcactccgaa       60

gttcagctgc aagaatccgg ccctggactc gtgaaaccaa gccagacact gagcctgact      120

tgcaccgtca ctggctatag catcaccagc gattacgcct ggaactggat aaggcagcca      180

cctggaaaga agctggagtg gatgggctac atcaactact ccggaagcac gtcctacaat      240

ccctcactta agagcagagt cacaatctca cgagacacct ccaagaacca gttctccctg      300

aaactgagct ccgttactgc cgctgatact gccgtgtact attgtgcaag gtggattggg      360

agctcagctt ggtatttcga cgtttgggga caaggcacac ttgtgaccgt ctcg            414


<210>  31
<211>  1948
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  jHuman VK2 4-1-(1) A18 JK2 acceptor framework 

<400>  31
gaagttcagc tgcaagaatc cggccctgga ctcgtgaaac caagccagac actgagcctg       60

acttgcaccg tcactggcta tagcatcacc agcgattacg cctggaactg gataaggcag      120

ccacctggaa agaagctgga gtggatgggc tacatcaact actccggaag cacgtcctac      180

aatccctcac ttaagagcag agtcacaatc tcacgagaca cctccaagaa ccagttctcc      240

ctgaaactga gctccgttac tgccgctgat actgccgtgt actattgtgc aaggtggatt      300

gggagctcag cttggtattt cgacgtttgg ggacaaggca cacttgtgac cgtctcgagc      360

gcttctacaa agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      420

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      600

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttggtgag      660

aggccagcac agggagggag ggtgtctgct ggaagccagg ctcagccctc ctgcctggac      720

gcaccccggc tgtgcagccc cagcccaggg cagcaaggca tgccccatct gtctcctcac      780

ccggaggcct ctgaccaccc cactcatgcc cagggagagg gtcttctgga tttttccacc      840

aggctccggg cagccacagg ctggatgccc ctaccccagg ccctgcgcat acaggggcag      900

gtgctgcgct cagacctgcc aagagccata tccgggagga ccctgcccct gacctaagcc      960

caccccaaag gccaaactct ccactccctc agctcagaca ccttctctcc tcccagatct     1020

gagtaactcc caatcttctc tctgcagagt ccaaatatgg tcccccatgc ccaccatgcc     1080

caggtaagcc aacccaggcc tcgccctcca gctcaaggcg ggacaggtgc cctagagtag     1140

cctgcatcca gggacaggcc ccagccgggt gctgacgcat ccacctccat ctcttcctca     1200

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact     1260

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac     1320

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag     1380

ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1440

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc     1500

tccatcgaga aaaccatctc caaagccaaa ggtgggaccc acggggtgcg agggccacat     1560

ggacagaggt cagctcggcc caccctctgc cctgggagtg accgctgtgc caacctctgt     1620

ccctacaggg cagccccgag agccacaggt gtacaccctg cccccatccc aggaggagat     1680

gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc     1740

cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct     1800

ggactccgac ggctccttct tcctctacag caggctaacc gtggacaaga gcaggtggca     1860

ggaggggaat gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca     1920

gaagagcctc tccctgtctc tgggtaaa                                        1948


<210>  32
<211>  2005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human VK2 4-1-(1) A18 JK2 acceptor framework 

<400>  32
atggagtgga gctgggtctt tctcttcttt ctctccgtga ctaccggtgt gcactccgaa       60

gttcagctgc aagaatccgg ccctggactc gtgaaaccaa gccagacact gagcctgact      120

tgcaccgtca ctggctatag catcaccagc gattacgcct ggaactggat aaggcagcca      180

cctggaaaga agctggagtg gatgggctac atcaactact ccggaagcac gtcctacaat      240

ccctcactta agagcagagt cacaatctca cgagacacct ccaagaacca gttctccctg      300

aaactgagct ccgttactgc cgctgatact gccgtgtact attgtgcaag gtggattggg      360

agctcagctt ggtatttcga cgtttgggga caaggcacac ttgtgaccgt ctcgagcgct      420

tctacaaagg gcccatccgt cttccccctg gcgccctgct ccaggagcac ctccgagagc      480

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      540

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac      660

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagagagt tggtgagagg      720

ccagcacagg gagggagggt gtctgctgga agccaggctc agccctcctg cctggacgca      780

ccccggctgt gcagccccag cccagggcag caaggcatgc cccatctgtc tcctcacccg      840

gaggcctctg accaccccac tcatgcccag ggagagggtc ttctggattt ttccaccagg      900

ctccgggcag ccacaggctg gatgccccta ccccaggccc tgcgcataca ggggcaggtg      960

ctgcgctcag acctgccaag agccatatcc gggaggaccc tgcccctgac ctaagcccac     1020

cccaaaggcc aaactctcca ctccctcagc tcagacacct tctctcctcc cagatctgag     1080

taactcccaa tcttctctct gcagagtcca aatatggtcc cccatgccca ccatgcccag     1140

gtaagccaac ccaggcctcg ccctccagct caaggcggga caggtgccct agagtagcct     1200

gcatccaggg acaggcccca gccgggtgct gacgcatcca cctccatctc ttcctcagca     1260

cctgagttcc tggggggacc atcagtcttc ctgttccccc caaaacccaa ggacactctc     1320

atgatctccc ggacccctga ggtcacgtgc gtggtggtgg acgtgagcca ggaagacccc     1380

gaggtccagt tcaactggta cgtggatggc gtggaggtgc ataatgccaa gacaaagccg     1440

cgggaggagc agttcaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     1500

gactggctga acggcaagga gtacaagtgc aaggtctcca acaaaggcct cccgtcctcc     1560

atcgagaaaa ccatctccaa agccaaaggt gggacccacg gggtgcgagg gccacatgga     1620

cagaggtcag ctcggcccac cctctgccct gggagtgacc gctgtgccaa cctctgtccc     1680

tacagggcag ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac     1740

caagaaccag gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt     1800

ggagtgggag agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga     1860

ctccgacggc tccttcttcc tctacagcag gctaaccgtg gacaagagca ggtggcagga     1920

ggggaatgtc ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa     1980

gagcctctcc ctgtctctgg gtaaa                                           2005


<210>  33
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human VH4 3-1 4-30.4 JH4 acceptor framework 

<400>  33
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca agtctagtca gagcctcctg catagtgatg gaaagaccta tttgtattgg      120

tacctgcaga agccaggcca gtctccacag ctcctaatct atgaagtttc cagccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgca tgcaaggtat acaccttcct      300

tacacttttg gccaggggac caagctggag atcaaa                                336


<210>  34
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human VH4 3-1 4-30.4 JH4 acceptor framework 

<400>  34
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtgatt actactggag ttggatccgc      120

cagcccccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gactgccgca gacacggccg tgtattactg tgccagatac      300

tttgactact ggggccaggg aaccctggtc accgtctcc                             339


<210>  35
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JK4

<400>  35

Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
1               5                   10                  


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JK2

<400>  36

Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10          