                         SEQUENCE LISTING

<110>  Duke University
       Bennett, Vann
       Healy, Jane
 
<120>  IDENTIFICATION OF A GENETIC RISK FACTOR FOR DIABETES

<130>  5405-435WO

<140>  PCT/US2011/028458
<141>  2011-03-15

<150>  US 61/313,976
<151>  2010-03-15

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  3936
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Thr Met Leu Gln Lys Ser Asp Ser Asn Ala Ser Phe Leu Arg 
1               5                   10                  15      


Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val Glu Tyr Leu Lys Gly 
            20                  25                  30          


Gly Ile Asp Ile Asn Thr Cys Asn Gln Asn Gly Leu Asn Ala Leu His 
        35                  40                  45              


Leu Ala Ala Lys Glu Gly His Val Gly Leu Val Gln Glu Leu Leu Gly 
    50                  55                  60                  


Arg Gly Ser Ser Val Asp Ser Ala Thr Lys Lys Gly Asn Thr Ala Leu 
65                  70                  75                  80  


His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val Val Lys Val Leu Val 
                85                  90                  95      


Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln Asn Gly Phe Thr Pro 
            100                 105                 110         


Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp Val Val Lys Tyr Leu 
        115                 120                 125             


Leu Glu Asn Gly Ala Asn Gln Ser Thr Ala Thr Glu Asp Gly Phe Thr 
    130                 135                 140                 


Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn Gln Ala Val Ala Ile 
145                 150                 155                 160 


Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg Leu Pro Ala Leu His 
                165                 170                 175     


Ile Ala Ala Arg Lys Asp Asp Thr Lys Ser Ala Ala Leu Leu Leu Gln 
            180                 185                 190         


Asn Asp His Asn Ala Asp Val Gln Ser Lys Met Met Val Asn Arg Thr 
        195                 200                 205             


Thr Glu Ser Gly Phe Thr Pro Leu His Ile Ala Ala His Tyr Gly Asn 
    210                 215                 220                 


Val Asn Val Ala Thr Leu Leu Leu Asn Arg Gly Ala Ala Val Asp Phe 
225                 230                 235                 240 


Thr Ala Arg Asn Gly Ile Thr Pro Leu His Val Ala Ser Lys Arg Gly 
                245                 250                 255     


Asn Thr Asn Met Val Lys Leu Leu Leu Asp Arg Gly Gly Gln Ile Asp 
            260                 265                 270         


Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His Cys Ala Ala Arg Ser 
        275                 280                 285             


Gly His Asp Gln Val Val Glu Leu Leu Leu Glu Arg Gly Ala Pro Leu 
    290                 295                 300                 


Leu Ala Arg Thr Lys Asn Gly Leu Ser Pro Leu His Met Ala Ala Gln 
305                 310                 315                 320 


Gly Asp His Val Glu Cys Val Lys His Leu Leu Gln His Lys Ala Pro 
                325                 330                 335     


Val Asp Asp Val Thr Leu Asp Tyr Leu Thr Ala Leu His Val Ala Ala 
            340                 345                 350         


His Cys Gly His Tyr Arg Val Thr Lys Leu Leu Leu Asp Lys Arg Ala 
        355                 360                 365             


Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Thr Pro Leu His Ile Ala 
    370                 375                 380                 


Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu Leu Val Lys Tyr Gly 
385                 390                 395                 400 


Ala Ser Ile Gln Ala Ile Thr Glu Ser Gly Leu Thr Pro Ile His Val 
                405                 410                 415     


Ala Ala Phe Met Gly His Leu Asn Ile Val Leu Leu Leu Leu Gln Asn 
            420                 425                 430         


Gly Ala Ser Pro Asp Val Thr Asn Ile Arg Gly Glu Thr Ala Leu His 
        435                 440                 445             


Met Ala Ala Arg Ala Gly Gln Val Glu Val Val Arg Cys Leu Leu Arg 
    450                 455                 460                 


Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu Glu Gln Thr Pro Leu 
465                 470                 475                 480 


His Ile Ala Ser Arg Leu Gly Lys Thr Glu Ile Val Gln Leu Leu Leu 
                485                 490                 495     


Gln His Met Ala His Pro Asp Ala Ala Thr Thr Asn Gly Tyr Thr Pro 
            500                 505                 510         


Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp Val Ala Ser Val Leu 
        515                 520                 525             


Leu Glu Ala Gly Ala Ala His Ser Leu Ala Thr Lys Lys Gly Phe Thr 
    530                 535                 540                 


Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu Asp Val Ala Lys Leu 
545                 550                 555                 560 


Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala Gly Lys Asn Gly Leu 
                565                 570                 575     


Thr Pro Leu His Val Ala Ala His Tyr Asp Asn Gln Lys Val Ala Leu 
            580                 585                 590         


Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala Thr Ala Lys Asn Gly 
        595                 600                 605             


Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn Gln Met Gln Ile Ala 
    610                 615                 620                 


Ser Thr Leu Leu Asn Tyr Gly Ala Glu Thr Asn Ile Val Thr Lys Gln 
625                 630                 635                 640 


Gly Val Thr Pro Leu His Leu Ala Ser Gln Glu Gly His Thr Asp Met 
                645                 650                 655     


Val Thr Leu Leu Leu Asp Lys Gly Ala Asn Ile His Met Ser Thr Lys 
            660                 665                 670         


Ser Gly Leu Thr Ser Leu His Leu Ala Ala Gln Glu Asp Lys Val Asn 
        675                 680                 685             


Val Ala Asp Ile Leu Thr Lys His Gly Ala Asp Gln Asp Ala His Thr 
    690                 695                 700                 


Lys Leu Gly Tyr Thr Pro Leu Ile Val Ala Cys His Tyr Gly Asn Val 
705                 710                 715                 720 


Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala Asn Val Asn Ala Lys 
                725                 730                 735     


Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala Ala Gln Gln Gly His 
            740                 745                 750         


Thr His Ile Ile Asn Val Leu Leu Gln His Gly Ala Lys Pro Asn Ala 
        755                 760                 765             


Thr Thr Ala Asn Gly Asn Thr Ala Leu Ala Ile Ala Lys Arg Leu Gly 
    770                 775                 780                 


Tyr Ile Ser Val Val Asp Thr Leu Lys Val Val Thr Glu Glu Val Thr 
785                 790                 795                 800 


Thr Thr Thr Thr Thr Ile Thr Glu Lys His Lys Leu Asn Val Pro Glu 
                805                 810                 815     


Thr Met Thr Glu Val Leu Asp Val Ser Asp Glu Glu Gly Asp Asp Thr 
            820                 825                 830         


Met Thr Gly Asp Gly Gly Glu Tyr Leu Arg Pro Glu Asp Leu Lys Glu 
        835                 840                 845             


Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe Leu Asp Gly Met Asn 
    850                 855                 860                 


Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser Asp Ser Leu Arg Ser 
865                 870                 875                 880 


Phe Ser Ser Asp Arg Ser His Thr Leu Ser His Ala Ser Tyr Leu Arg 
                885                 890                 895     


Asp Ser Ala Val Met Asp Asp Ser Val Val Ile Pro Ser His Gln Val 
            900                 905                 910         


Ser Thr Leu Ala Lys Glu Ala Glu Arg Asn Ser Tyr Arg Leu Ser Trp 
        915                 920                 925             


Gly Thr Glu Asn Leu Asp Asn Val Ala Leu Ser Ser Ser Pro Ile His 
    930                 935                 940                 


Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ala Met 
945                 950                 955                 960 


Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile Ile Pro Pro Arg Lys 
                965                 970                 975     


Cys Thr Ala Pro Thr Arg Val Thr Cys Arg Leu Val Lys Arg His Arg 
            980                 985                 990         


Leu Ala Thr Met Pro Pro Met Val  Glu Gly Glu Gly Leu  Ala Ser Arg 
        995                 1000                 1005             


Leu Ile  Glu Val Gly Pro Ser  Gly Ala Gln Phe Leu  Gly Lys Leu 
    1010                 1015                 1020             


His Leu  Pro Thr Ala Pro Pro  Pro Leu Asn Glu Gly  Glu Ser Leu 
    1025                 1030                 1035             


Val Ser  Arg Ile Leu Gln Leu  Gly Pro Pro Gly Thr  Lys Phe Leu 
    1040                 1045                 1050             


Gly Pro  Val Ile Val Glu Ile  Pro His Phe Ala Ala  Leu Arg Gly 
    1055                 1060                 1065             


Lys Glu  Arg Glu Leu Val Val  Leu Arg Ser Glu Asn  Gly Asp Ser 
    1070                 1075                 1080             


Trp Lys  Glu His Phe Cys Asp  Tyr Thr Glu Asp Glu  Leu Asn Glu 
    1085                 1090                 1095             


Ile Leu  Asn Gly Met Asp Glu  Val Leu Asp Ser Pro  Glu Asp Leu 
    1100                 1105                 1110             


Glu Lys  Lys Arg Ile Cys Arg  Ile Ile Thr Arg Asp  Phe Pro Gln 
    1115                 1120                 1125             


Tyr Phe  Ala Val Val Ser Arg  Ile Lys Gln Asp Ser  Asn Leu Ile 
    1130                 1135                 1140             


Gly Pro  Glu Gly Gly Val Leu  Ser Ser Thr Val Val  Pro Gln Val 
    1145                 1150                 1155             


Gln Ala  Val Phe Pro Glu Gly  Ala Leu Thr Lys Arg  Ile Arg Val 
    1160                 1165                 1170             


Gly Leu  Gln Ala Gln Pro Met  His Ser Glu Leu Val  Lys Lys Ile 
    1175                 1180                 1185             


Leu Gly  Asn Lys Ala Thr Phe  Ser Pro Ile Val Thr  Leu Glu Pro 
    1190                 1195                 1200             


Arg Arg  Arg Lys Phe His Lys  Pro Ile Thr Met Thr  Ile Pro Val 
    1205                 1210                 1215             


Pro Lys  Ala Ser Ser Asp Val  Met Leu Asn Gly Phe  Gly Gly Asp 
    1220                 1225                 1230             


Ala Pro  Thr Leu Arg Leu Leu  Cys Ser Ile Thr Gly  Gly Thr Thr 
    1235                 1240                 1245             


Pro Ala  Gln Trp Glu Asp Ile  Thr Gly Thr Thr Pro  Leu Thr Phe 
    1250                 1255                 1260             


Val Asn  Glu Cys Val Ser Phe  Thr Thr Asn Val Ser  Ala Arg Phe 
    1265                 1270                 1275             


Trp Leu  Ile Asp Cys Arg Gln  Ile Gln Glu Ser Val  Thr Phe Ala 
    1280                 1285                 1290             


Ser Gln  Val Tyr Arg Glu Ile  Ile Cys Val Pro Tyr  Met Ala Lys 
    1295                 1300                 1305             


Phe Val  Val Phe Ala Lys Ser  His Asp Pro Ile Glu  Ala Arg Leu 
    1310                 1315                 1320             


Arg Cys  Phe Cys Met Thr Asp  Asp Lys Val Asp Lys  Thr Leu Glu 
    1325                 1330                 1335             


Gln Gln  Glu Asn Phe Ala Glu  Val Ala Arg Ser Arg  Asp Val Glu 
    1340                 1345                 1350             


Val Leu  Glu Gly Lys Pro Ile  Tyr Val Asp Cys Phe  Gly Asn Leu 
    1355                 1360                 1365             


Val Pro  Leu Thr Lys Ser Gly  Gln His His Ile Phe  Ser Phe Phe 
    1370                 1375                 1380             


Ala Phe  Lys Glu Asn Arg Leu  Pro Leu Phe Val Lys  Val Arg Asp 
    1385                 1390                 1395             


Thr Thr  Gln Glu Pro Cys Gly  Arg Leu Ser Phe Met  Lys Glu Pro 
    1400                 1405                 1410             


Lys Ser  Thr Arg Gly Leu Val  His Gln Ala Ile Cys  Asn Leu Asn 
    1415                 1420                 1425             


Ile Thr  Leu Pro Ile Tyr Thr  Lys Glu Ser Glu Ser  Asp Gln Glu 
    1430                 1435                 1440             


Gln Glu  Glu Glu Ile Asp Met  Thr Ser Glu Lys Asn  Asp Glu Thr 
    1445                 1450                 1455             


Glu Ser  Thr Glu Thr Ser Val  Leu Lys Ser His Leu  Val Asn Glu 
    1460                 1465                 1470             


Val Pro  Val Leu Ala Ser Pro  Asp Leu Leu Ser Glu  Val Ser Glu 
    1475                 1480                 1485             


Met Lys  Gln Asp Leu Ile Lys  Met Thr Ala Ile Leu  Thr Thr Asp 
    1490                 1495                 1500             


Val Ser  Asp Lys Ala Gly Ser  Ile Lys Val Lys Glu  Leu Val Lys 
    1505                 1510                 1515             


Ala Ala  Glu Glu Glu Pro Gly  Glu Pro Phe Glu Ile  Val Glu Arg 
    1520                 1525                 1530             


Val Lys  Glu Asp Leu Glu Lys  Val Asn Glu Ile Leu  Arg Ser Gly 
    1535                 1540                 1545             


Thr Cys  Thr Arg Asp Glu Ser  Ser Val Gln Ser Ser  Arg Ser Glu 
    1550                 1555                 1560             


Arg Gly  Leu Val Glu Glu Glu  Trp Val Ile Val Ser  Asp Glu Glu 
    1565                 1570                 1575             


Ile Glu  Glu Ala Arg Gln Lys  Ala Pro Leu Glu Ile  Thr Glu Tyr 
    1580                 1585                 1590             


Pro Cys  Val Glu Val Arg Ile  Asp Lys Glu Ile Lys  Gly Lys Val 
    1595                 1600                 1605             


Glu Lys  Asp Ser Thr Gly Leu  Val Asn Tyr Leu Thr  Asp Asp Leu 
    1610                 1615                 1620             


Asn Thr  Cys Val Pro Leu Pro  Lys Glu Gln Leu Gln  Thr Val Gln 
    1625                 1630                 1635             


Asp Lys  Ala Gly Lys Lys Cys  Glu Ala Leu Ala Val  Gly Arg Ser 
    1640                 1645                 1650             


Ser Glu  Lys Glu Gly Lys Asp  Ile Pro Pro Asp Glu  Thr Gln Ser 
    1655                 1660                 1665             


Thr Gln  Lys Gln His Lys Pro  Ser Leu Gly Ile Lys  Lys Pro Val 
    1670                 1675                 1680             


Arg Arg  Lys Leu Lys Glu Lys  Gln Lys Gln Lys Glu  Glu Gly Leu 
    1685                 1690                 1695             


Gln Ala  Ser Ala Glu Lys Ala  Glu Leu Lys Lys Gly  Ser Ser Glu 
    1700                 1705                 1710             


Glu Ser  Leu Gly Glu Asp Pro  Gly Leu Ala Pro Glu  Pro Leu Pro 
    1715                 1720                 1725             


Thr Val  Lys Ala Thr Ser Pro  Leu Ile Glu Glu Thr  Pro Ile Gly 
    1730                 1735                 1740             


Ser Ile  Lys Asp Lys Val Lys  Ala Leu Gln Lys Arg  Val Glu Asp 
    1745                 1750                 1755             


Glu Gln  Lys Gly Arg Ser Lys  Leu Pro Ile Arg Val  Lys Gly Lys 
    1760                 1765                 1770             


Glu Asp  Val Pro Lys Lys Thr  Thr His Arg Pro His  Pro Ala Ala 
    1775                 1780                 1785             


Ser Pro  Ser Leu Lys Ser Glu  Arg His Ala Pro Gly  Ser Pro Ser 
    1790                 1795                 1800             


Pro Lys  Thr Glu Arg His Ser  Thr Leu Ser Ser Ser  Ala Lys Thr 
    1805                 1810                 1815             


Glu Arg  His Pro Pro Val Ser  Pro Ser Ser Lys Thr  Glu Lys His 
    1820                 1825                 1830             


Ser Pro  Val Ser Pro Ser Ala  Lys Thr Glu Arg His  Ser Pro Ala 
    1835                 1840                 1845             


Ser Ser  Ser Ser Lys Thr Glu  Lys His Ser Pro Val  Ser Pro Ser 
    1850                 1855                 1860             


Thr Lys  Thr Glu Arg His Ser  Pro Val Ser Ser Thr  Lys Thr Glu 
    1865                 1870                 1875             


Arg His  Pro Pro Val Ser Pro  Ser Gly Lys Thr Asp  Lys Arg Pro 
    1880                 1885                 1890             


Pro Val  Ser Pro Ser Gly Arg  Thr Glu Lys His Pro  Pro Val Ser 
    1895                 1900                 1905             


Pro Gly  Arg Thr Glu Lys Arg  Leu Pro Val Ser Pro  Ser Gly Arg 
    1910                 1915                 1920             


Thr Asp  Lys His Gln Pro Val  Ser Thr Ala Gly Lys  Thr Glu Lys 
    1925                 1930                 1935             


His Leu  Pro Val Ser Pro Ser  Gly Lys Thr Glu Lys  Gln Pro Pro 
    1940                 1945                 1950             


Val Ser  Pro Thr Ser Lys Thr  Glu Arg Ile Glu Glu  Thr Met Ser 
    1955                 1960                 1965             


Val Arg  Glu Leu Met Lys Ala  Phe Gln Ser Gly Gln  Asp Pro Ser 
    1970                 1975                 1980             


Lys His  Lys Thr Gly Leu Phe  Glu His Lys Ser Ala  Lys Gln Lys 
    1985                 1990                 1995             


Gln Pro  Gln Glu Lys Gly Lys  Val Arg Val Glu Lys  Glu Lys Gly 
    2000                 2005                 2010             


Pro Ile  Leu Thr Gln Arg Glu  Ala Gln Lys Thr Glu  Asn Gln Thr 
    2015                 2020                 2025             


Ile Lys  Arg Gly Gln Arg Leu  Pro Val Thr Gly Thr  Ala Glu Ser 
    2030                 2035                 2040             


Lys Arg  Gly Val Arg Val Ser  Ser Ile Gly Val Lys  Lys Glu Asp 
    2045                 2050                 2055             


Ala Ala  Gly Gly Lys Glu Lys  Val Leu Ser His Lys  Ile Pro Glu 
    2060                 2065                 2070             


Pro Val  Gln Ser Val Pro Glu  Glu Glu Ser His Arg  Glu Ser Glu 
    2075                 2080                 2085             


Val Pro  Lys Glu Lys Met Ala  Asp Glu Gln Gly Asp  Met Asp Leu 
    2090                 2095                 2100             


Gln Ile  Ser Pro Asp Arg Lys  Thr Ser Thr Asp Phe  Ser Glu Val 
    2105                 2110                 2115             


Ile Lys  Gln Glu Leu Glu Asp  Asn Asp Lys Tyr Gln  Gln Phe Arg 
    2120                 2125                 2130             


Leu Ser  Glu Glu Thr Glu Lys  Ala Gln Leu His Leu  Asp Gln Val 
    2135                 2140                 2145             


Leu Thr  Ser Pro Phe Asn Thr  Thr Phe Pro Leu Asp  Tyr Met Lys 
    2150                 2155                 2160             


Asp Glu  Phe Leu Pro Ala Leu  Ser Leu Gln Ser Gly  Ala Leu Asp 
    2165                 2170                 2175             


Gly Ser  Ser Glu Ser Leu Lys  Asn Glu Gly Val Ala  Gly Ser Pro 
    2180                 2185                 2190             


Cys Gly  Ser Leu Met Glu Gly  Thr Pro Gln Ile Ser  Ser Glu Glu 
    2195                 2200                 2205             


Ser Tyr  Lys His Glu Gly Leu  Ala Glu Thr Pro Glu  Thr Ser Pro 
    2210                 2215                 2220             


Glu Ser  Leu Ser Phe Ser Pro  Lys Lys Ser Glu Glu  Gln Thr Gly 
    2225                 2230                 2235             


Glu Thr  Lys Glu Ser Thr Lys  Thr Glu Thr Thr Thr  Glu Ile Arg 
    2240                 2245                 2250             


Ser Glu  Lys Glu His Pro Thr  Thr Lys Asp Ile Thr  Gly Gly Ser 
    2255                 2260                 2265             


Glu Glu  Arg Gly Ala Thr Val  Thr Glu Asp Ser Glu  Thr Ser Thr 
    2270                 2275                 2280             


Glu Ser  Phe Gln Lys Glu Ala  Thr Leu Gly Ser Pro  Lys Asp Thr 
    2285                 2290                 2295             


Ser Pro  Lys Arg Gln Asp Asp  Cys Thr Gly Ser Cys  Ser Val Ala 
    2300                 2305                 2310             


Leu Ala  Lys Glu Thr Pro Thr  Gly Leu Thr Glu Glu  Ala Ala Cys 
    2315                 2320                 2325             


Asp Glu  Gly Gln Arg Thr Phe  Gly Ser Ser Ala His  Lys Thr Gln 
    2330                 2335                 2340             


Thr Asp  Ser Glu Val Gln Glu  Ser Thr Ala Thr Ser  Asp Glu Thr 
    2345                 2350                 2355             


Lys Ala  Leu Pro Leu Pro Glu  Ala Ser Val Lys Thr  Asp Thr Gly 
    2360                 2365                 2370             


Thr Glu  Ser Lys Pro Gln Gly  Val Ile Arg Ser Pro  Gln Gly Leu 
    2375                 2380                 2385             


Glu Leu  Ala Leu Pro Ser Arg  Asp Ser Glu Val Leu  Ser Ala Val 
    2390                 2395                 2400             


Ala Asp  Asp Ser Leu Ala Val  Ser His Lys Asp Ser  Leu Glu Ala 
    2405                 2410                 2415             


Ser Pro  Val Leu Glu Asp Asn  Ser Ser His Lys Thr  Pro Asp Ser 
    2420                 2425                 2430             


Leu Glu  Pro Ser Pro Leu Lys  Glu Ser Pro Cys Arg  Asp Ser Leu 
    2435                 2440                 2445             


Glu Ser  Ser Pro Val Glu Pro  Lys Met Lys Ala Gly  Ile Phe Pro 
    2450                 2455                 2460             


Ser His  Phe Pro Leu Pro Ala  Ala Val Ala Lys Thr  Glu Leu Leu 
    2465                 2470                 2475             


Thr Glu  Val Ala Ser Val Arg  Ser Arg Leu Leu Arg  Asp Pro Asp 
    2480                 2485                 2490             


Gly Ser  Ala Glu Asp Asp Ser  Leu Glu Gln Thr Ser  Leu Met Glu 
    2495                 2500                 2505             


Ser Ser  Gly Lys Ser Pro Leu  Ser Pro Asp Thr Pro  Ser Ser Glu 
    2510                 2515                 2520             


Glu Val  Ser Tyr Glu Val Thr  Pro Lys Thr Thr Asp  Val Ser Thr 
    2525                 2530                 2535             


Pro Lys  Pro Ala Val Ile His  Glu Cys Ala Glu Glu  Asp Asp Ser 
    2540                 2545                 2550             


Glu Asn  Gly Glu Lys Lys Arg  Phe Thr Pro Glu Glu  Glu Met Phe 
    2555                 2560                 2565             


Lys Met  Val Thr Lys Ile Lys  Met Phe Asp Glu Leu  Glu Gln Glu 
    2570                 2575                 2580             


Ala Lys  Gln Lys Arg Asp Tyr  Lys Lys Glu Pro Lys  Gln Glu Glu 
    2585                 2590                 2595             


Ser Ser  Ser Ser Ser Asp Pro  Asp Ala Asp Cys Ser  Val Asp Val 
    2600                 2605                 2610             


Asp Glu  Pro Lys His Thr Gly  Ser Gly Glu Asp Glu  Ser Gly Val 
    2615                 2620                 2625             


Pro Val  Leu Val Thr Ser Glu  Ser Arg Lys Val Ser  Ser Ser Ser 
    2630                 2635                 2640             


Glu Ser  Glu Pro Glu Leu Ala  Gln Leu Lys Lys Gly  Ala Asp Ser 
    2645                 2650                 2655             


Gly Leu  Leu Pro Glu Pro Val  Ile Arg Val Gln Pro  Pro Ser Pro 
    2660                 2665                 2670             


Leu Pro  Ser Ser Met Asp Ser  Asn Ser Ser Pro Glu  Glu Val Gln 
    2675                 2680                 2685             


Phe Gln  Pro Val Val Ser Lys  Gln Tyr Thr Phe Lys  Met Asn Glu 
    2690                 2695                 2700             


Asp Thr  Gln Glu Glu Pro Gly  Lys Ser Glu Glu Glu  Lys Asp Ser 
    2705                 2710                 2715             


Glu Ser  His Leu Ala Glu Asp  Arg His Ala Val Ser  Thr Glu Ala 
    2720                 2725                 2730             


Glu Asp  Arg Ser Tyr Asp Lys  Leu Asn Arg Asp Thr  Asp Gln Pro 
    2735                 2740                 2745             


Lys Ile  Cys Asp Gly His Gly  Cys Glu Ala Met Ser  Pro Ser Ser 
    2750                 2755                 2760             


Ser Ala  Ala Pro Val Ser Ser  Gly Leu Gln Ser Pro  Thr Gly Asp 
    2765                 2770                 2775             


Asp Val  Asp Glu Gln Pro Val  Ile Tyr Lys Glu Ser  Leu Ala Leu 
    2780                 2785                 2790             


Gln Gly  Thr His Glu Lys Asp  Thr Glu Gly Glu Glu  Leu Asp Val 
    2795                 2800                 2805             


Ser Arg  Ala Glu Ser Pro Gln  Ala Asp Cys Pro Ser  Glu Ser Phe 
    2810                 2815                 2820             


Ser Ser  Ser Ser Ser Leu Pro  His Cys Leu Val Ser  Glu Gly Lys 
    2825                 2830                 2835             


Glu Leu  Asp Glu Asp Ile Ser  Ala Thr Ser Ser Ile  Gln Lys Thr 
    2840                 2845                 2850             


Glu Val  Thr Lys Thr Asp Glu  Thr Phe Glu Asn Leu  Pro Lys Asp 
    2855                 2860                 2865             


Cys Pro  Ser Gln Asp Ser Ser  Ile Thr Thr Gln Thr  Asp Arg Phe 
    2870                 2875                 2880             


Ser Met  Asp Val Pro Val Ser  Asp Leu Ala Glu Asn  Asp Glu Ile 
    2885                 2890                 2895             


Tyr Asp  Pro Gln Ile Thr Ser  Pro Tyr Glu Asn Val  Pro Ser Gln 
    2900                 2905                 2910             


Ser Phe  Phe Ser Ser Glu Glu  Ser Lys Thr Gln Thr  Asp Ala Asn 
    2915                 2920                 2925             


His Thr  Thr Ser Phe His Ser  Ser Glu Val Tyr Ser  Val Thr Ile 
    2930                 2935                 2940             


Thr Ser  Pro Val Glu Asp Val  Val Val Ala Ser Ser  Ser Ser Gly 
    2945                 2950                 2955             


Thr Val  Leu Ser Lys Glu Ser  Asn Phe Glu Gly Gln  Asp Ile Lys 
    2960                 2965                 2970             


Met Glu  Ser Gln Gln Glu Ser  Thr Leu Trp Glu Met  Gln Ser Asp 
    2975                 2980                 2985             


Ser Val  Ser Ser Ser Phe Glu  Pro Thr Met Ser Ala  Thr Thr Thr 
    2990                 2995                 3000             


Val Val  Gly Glu Gln Ile Ser  Lys Val Ile Ile Thr  Lys Thr Asp 
    3005                 3010                 3015             


Val Asp  Ser Asp Ser Trp Ser  Glu Ile Arg Glu Asp  Asp Glu Ala 
    3020                 3025                 3030             


Phe Glu  Ala Arg Val Lys Glu  Glu Glu Gln Lys Ile  Phe Gly Leu 
    3035                 3040                 3045             


Met Val  Asp Arg Gln Ser Gln  Gly Thr Thr Pro Asp  Thr Thr Pro 
    3050                 3055                 3060             


Ala Arg  Thr Pro Thr Glu Glu  Gly Thr Pro Thr Ser  Glu Gln Asn 
    3065                 3070                 3075             


Pro Phe  Leu Phe Gln Glu Gly  Lys Leu Phe Glu Met  Thr Arg Ser 
    3080                 3085                 3090             


Gly Ala  Ile Asp Met Thr Lys  Arg Ser Tyr Ala Asp  Glu Ser Phe 
    3095                 3100                 3105             


His Phe  Phe Gln Ile Gly Gln  Glu Ser Arg Glu Glu  Thr Leu Ser 
    3110                 3115                 3120             


Glu Asp  Val Lys Glu Gly Ala  Thr Gly Ala Asp Pro  Leu Pro Leu 
    3125                 3130                 3135             


Glu Thr  Ser Ala Glu Ser Leu  Ala Leu Ser Glu Ser  Lys Glu Thr 
    3140                 3145                 3150             


Val Asp  Asp Glu Ala Asp Leu  Leu Pro Asp Asp Val  Ser Glu Glu 
    3155                 3160                 3165             


Val Glu  Glu Ile Pro Ala Ser  Asp Ala Gln Leu Asn  Ser Gln Met 
    3170                 3175                 3180             


Gly Ile  Ser Ala Ser Thr Glu  Thr Pro Thr Lys Glu  Ala Val Ser 
    3185                 3190                 3195             


Val Gly  Thr Lys Asp Leu Pro  Thr Val Gln Thr Gly  Asp Ile Pro 
    3200                 3205                 3210             


Pro Leu  Ser Gly Val Lys Gln  Ile Ser Cys Pro Asp  Ser Ser Glu 
    3215                 3220                 3225             


Pro Ala  Val Gln Val Gln Leu  Asp Phe Ser Thr Leu  Thr Arg Ser 
    3230                 3235                 3240             


Val Tyr  Ser Asp Arg Gly Asp  Asp Ser Pro Asp Ser  Ser Pro Glu 
    3245                 3250                 3255             


Glu Gln  Lys Ser Val Ile Glu  Ile Pro Thr Ala Pro  Met Glu Asn 
    3260                 3265                 3270             


Val Pro  Phe Thr Glu Ser Lys  Ser Lys Ile Pro Val  Arg Thr Met 
    3275                 3280                 3285             


Pro Thr  Ser Thr Pro Ala Pro  Pro Ser Ala Glu Tyr  Glu Ser Ser 
    3290                 3295                 3300             


Val Ser  Glu Asp Phe Leu Ser  Ser Val Asp Glu Glu  Asn Lys Ala 
    3305                 3310                 3315             


Asp Glu  Ala Lys Pro Lys Ser  Lys Leu Pro Val Lys  Val Pro Leu 
    3320                 3325                 3330             


Gln Arg  Val Glu Gln Gln Leu  Ser Asp Leu Asp Thr  Ser Val Gln 
    3335                 3340                 3345             


Lys Thr  Val Ala Pro Gln Gly  Gln Asp Met Ala Ser  Ile Ala Pro 
    3350                 3355                 3360             


Asp Asn  Arg Ser Lys Ser Glu  Ser Asp Ala Ser Ser  Leu Asp Ser 
    3365                 3370                 3375             


Lys Thr  Lys Cys Pro Val Lys  Thr Arg Ser Tyr Thr  Glu Thr Glu 
    3380                 3385                 3390             


Thr Glu  Ser Arg Glu Arg Ala  Glu Glu Leu Glu Leu  Glu Ser Glu 
    3395                 3400                 3405             


Glu Gly  Ala Thr Arg Pro Lys  Ile Leu Thr Ser Arg  Leu Pro Val 
    3410                 3415                 3420             


Lys Ser  Arg Ser Thr Thr Ser  Ser Cys Arg Gly Gly  Thr Ser Pro 
    3425                 3430                 3435             


Thr Lys  Glu Ser Lys Glu His  Phe Phe Asp Leu Tyr  Arg Asn Ser 
    3440                 3445                 3450             


Ile Glu  Phe Phe Glu Glu Ile  Ser Asp Glu Ala Ser  Lys Leu Val 
    3455                 3460                 3465             


Asp Arg  Leu Thr Gln Ser Glu  Arg Glu Gln Glu Ile  Val Ser Asp 
    3470                 3475                 3480             


Asp Glu  Ser Ser Ser Ala Leu  Glu Val Ser Val Ile  Glu Asn Leu 
    3485                 3490                 3495             


Pro Pro  Val Glu Thr Glu His  Ser Val Pro Glu Asp  Ile Phe Asp 
    3500                 3505                 3510             


Thr Arg  Pro Ile Trp Asp Glu  Ser Ile Glu Thr Leu  Ile Glu Arg 
    3515                 3520                 3525             


Ile Pro  Asp Glu Asn Gly His  Asp His Ala Glu Asp  Pro Gln Asp 
    3530                 3535                 3540             


Glu Gln  Glu Arg Ile Glu Glu  Arg Leu Ala Tyr Ile  Ala Asp His 
    3545                 3550                 3555             


Leu Gly  Phe Ser Trp Thr Glu  Leu Ala Arg Glu Leu  Asp Phe Thr 
    3560                 3565                 3570             


Glu Glu  Gln Ile His Gln Ile  Arg Ile Glu Asn Pro  Asn Ser Leu 
    3575                 3580                 3585             


Gln Asp  Gln Ser His Ala Leu  Leu Lys Tyr Trp Leu  Glu Arg Asp 
    3590                 3595                 3600             


Gly Lys  His Ala Thr Asp Thr  Asn Leu Val Glu Cys  Leu Thr Lys 
    3605                 3610                 3615             


Ile Asn  Arg Met Asp Ile Val  His Leu Met Glu Thr  Asn Thr Glu 
    3620                 3625                 3630             


Pro Leu  Gln Glu Arg Ile Ser  His Ser Tyr Ala Glu  Ile Glu Gln 
    3635                 3640                 3645             


Thr Ile  Thr Leu Asp His Ser  Glu Gly Phe Ser Val  Leu Gln Glu 
    3650                 3655                 3660             


Glu Leu  Cys Thr Ala Gln His  Lys Gln Lys Glu Glu  Gln Ala Val 
    3665                 3670                 3675             


Ser Lys  Glu Ser Glu Thr Cys  Asp His Pro Pro Ile  Val Ser Glu 
    3680                 3685                 3690             


Glu Asp  Ile Ser Val Gly Tyr  Ser Thr Phe Gln Asp  Gly Val Pro 
    3695                 3700                 3705             


Lys Thr  Glu Gly Asp Ser Ser  Ala Thr Ala Leu Phe  Pro Gln Thr 
    3710                 3715                 3720             


His Lys  Glu Gln Val Gln Gln  Asp Phe Ser Gly Lys  Met Gln Asp 
    3725                 3730                 3735             


Leu Pro  Glu Glu Ser Ser Leu  Glu Tyr Gln Gln Glu  Tyr Phe Val 
    3740                 3745                 3750             


Thr Thr  Pro Gly Thr Glu Thr  Ser Glu Thr Gln Lys  Ala Met Ile 
    3755                 3760                 3765             


Val Pro  Ser Ser Pro Ser Lys  Thr Pro Glu Glu Val  Ser Thr Pro 
    3770                 3775                 3780             


Ala Glu  Glu Glu Lys Leu Tyr  Leu Gln Thr Pro Thr  Ser Ser Glu 
    3785                 3790                 3795             


Arg Gly  Gly Ser Pro Ile Ile  Gln Glu Pro Glu Glu  Pro Ser Glu 
    3800                 3805                 3810             


His Arg  Glu Glu Ser Ser Pro  Arg Lys Thr Ser Leu  Val Ile Val 
    3815                 3820                 3825             


Glu Ser  Ala Asp Asn Gln Pro  Glu Thr Cys Glu Arg  Leu Asp Glu 
    3830                 3835                 3840             


Asp Ala  Ala Phe Glu Lys Gly  Asp Asp Met Pro Glu  Ile Pro Pro 
    3845                 3850                 3855             


Glu Thr  Val Thr Glu Glu Glu  Tyr Ile Asp Glu His  Gly His Thr 
    3860                 3865                 3870             


Val Val  Lys Lys Val Thr Arg  Lys Ile Ile Arg Arg  Tyr Val Ser 
    3875                 3880                 3885             


Ser Glu  Gly Thr Glu Lys Glu  Glu Ile Met Val Gln  Gly Met Pro 
    3890                 3895                 3900             


Gln Glu  Pro Val Asn Ile Glu  Glu Gly Asp Gly Tyr  Ser Lys Val 
    3905                 3910                 3915             


Ile Lys  Arg Val Val Leu Lys  Ser Asp Thr Glu Gln  Ser Glu Asp 
    3920                 3925                 3930             


Asn Asn  Glu 
    3935     


<210>  2
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic siRNA oligonucleotide

<400>  2
ggccagaaga tctcaagga                                                    19


<210>  3
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic siRNA oligonucleotide

<400>  3
gctgtgtagc attttaaca                                                    19


<210>  4
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic siRNA oligonucleotide

<400>  4
ggcccgaaga gctcaagga                                                    19


<210>  5
<211>  62
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is g or a

<400>  5
agcccagcag cagcactntc tctcctcaaa tgcaccagga gccagttcaa caagatttct       60

ca                                                                      62


<210>  6
<211>  60
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is c or t

<400>  6
atcattaggn ggtacgtttc ctctgatggc acagagaagg aggaggttac catgcaggga       60


<210>  7
<211>  201
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  n is a or g

<400>  7
gttgaaaggg tatttattta ctctttcctt ttcttctaaa tactctctac tcttccttct       60

ctcttttttc catcttgcat ggcatcttgg ggcggaaagg natcagagtc agatcaagaa      120

caggaggaag aggtaatttt atgacagtgt cacttgttat cggctgtgtc attgctgtaa      180

ccactaataa gagcacatag t                                                201


<210>  8
<211>  201
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  n is c or t

<400>  8
ctttctttga atgaatcagt actgtggttc ctctcctgtc atagacaacc tttggccatt       60

ctgtttttga ccttctccag atccacagga tgagcaggaa nggatcgagg aaaggctggc      120

ttatattgct gatcaccttg gcttcagctg gacaggtaaa aagaatgtga cccaggtttt      180

caacaaaacc tgacatagat g                                                201


<210>  9
<211>  201
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  n is t or a

<400>  9
tatcaaaaat ttagtaaggc agttgagtga aagagatttt taagagtacc tctcagacat       60

aataaatgct gtttctctaa tgtgtcagat accaacctcg ntgaatgtct caccaagatc      120

aaccgaatgg atattgttca tctcatggag accaacacag aacctctcca ggagcgcatc      180

agtcatagtt atgcagaaat t                                                201


<210>  10
<211>  201
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  n is a or c

<400>  10
ctcaccaaga tcaaccgaat ggatattgtt catctcatgg agaccaacac agaacctctc       60

caggagcgca tcagtcatag ttatgcagaa attgaacaga ncattacact ggatcatagt      120

gaaggtcaaa ctgtgtgtgt gtatgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttgtgtc      180

tgtgtgtggt taattgaggc a                                                201


<210>  11
<211>  51
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n is c or a

<400>  11
ctgaggggga cagctcagca acagcantct ttccccaaac tcacaaggag c                51


<210>  12
<211>  201
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  n is c or a

<400>  12
atcgtctcag aggaagacat ttctgttggt tattccactt ttcaggatgg cgtccccaaa       60

actgaggggg acagctcagc aacagcactc tttccccaaa ntcacaagga gcaagttcaa      120

caggatttct cagggaaaat gcaagacctg cctgaagagt catctctgga atatcagcag      180

gaatatttgt gagtttccaa a                                                201


<210>  13
<211>  201
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  n is c or t

<400>  13
acaaacttcc tgtttaaaat ttatcaattc catggtactg tcacacaaaa ataagataca       60

caaatgaaat acatttcagg ttactaggaa aatcattagg nggtatgtat cctctgaagg      120

cacagagaaa gaagagatta tggtgcaggg aatgccacag gaacctgtca acatcgagga      180

aggggatggc tattccaaag t                                                201


<210>  14
<211>  201
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  n is t or c

<400>  14
ctgtttaaaa tttatcaatt ccatggtact gtcacacaaa aataagatac acaaatgaaa       60

tacatttcag gttactagga aaatcattag gcggtatgta ncctctgaag gcacagagaa      120

agaagagatt atggtgcagg gaatgccaca ggaacctgtc aacatcgagg aaggggatgg      180

ctattccaaa gttataaagc g                                                201


<210>  15
<211>  167
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  n is g or a

<400>  15
atttcaggtt actaggaaaa tcattaggcg gtatgtatcc tctgaaggca cagagaaaga       60

agagattatg gtgcagggaa tgccacagga acctgtcaac atcnaggaag gggatggcta      120

ttccaaagtt ataaagcgtg ttgtattgaa gagtgacacc gagcagt                    167


<210>  16
<211>  201
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  n is g or a

<400>  16
atatcaaaaa tttagtaagg cagttgagtg aaagagattt ttaagagtac ctctcagaca       60

taataaatgc tgtttctcta atgtgtcaga taccaacctc nttgaatgtc tcaccaagat      120

caaccgaatg gatattgttc atctcatgga gaccaacaca gaacctctcc aggagcgcat      180

cagtcatagt tatgcagaaa t                                                201


<210>  17
<211>  201
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  n is g or a

<400>  17
ttgaatgaat cagtactgtg gttcctctcc tgtcatagac aacctttggc cattctgttt       60

ttgaccttct ccagatccac aggatgagca ggaacggatc naggaaaggc tggcttatat      120

tgctgatcac cttggcttca gctggacagg taaaaagaat gtgacccagg ttttcaacaa      180

aacctgacat agatgcatca g                                                201


<210>  18
<211>  201
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  n is g or c

<400>  18
tacctccaga ccccaacatc cagcgagcgg ggaggctctc ccatcataca agaacccgaa       60

gagccctcag agcacagaga ggagagctct ccgcggaaaa ncagcctcgt aatagtggag      120

tctgccgata accagcctga gacctgtgaa agactcgatg aagatgcagc ttttgaaaag      180

gtaagacatt cctctccact t                                                201


<210>  19
<211>  201
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  n is c or a

<400>  19
tacctccaga ccccaacatc cagcgagcgg ggaggctctc ccatcataca agaacccgaa       60

gagccctcag agcacagaga ggagagctct ccgcggaaaa ncagcctcgt aatagtggag      120

tctgccgata accagcctga gacctgtgaa agactcgatg aagatgcagc ttttgaaaag      180

gtaagacatt cctctccact t                                                201


<210>  20
<211>  201
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  n is g or a

<400>  20
caatataggt aagcttcaac taaatactta aatcattctg cctttagggt tctcggtact       60

tcaagaggag ttatgcactg cacagcacaa gcagaaagag nagcaagctg tttctaaaga      120

aagtgagacc tgcgatcacc ctcctatcgt ctcagaggaa gacatttctg ttggttattc      180

cacttttcag gatggcgtcc c                                                201


<210>  21
<211>  201
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  n is a or c

<400>  21
cagatagggg tgatgattct cccgattctt ccccagaaga acagaaatca gtaatcgaga       60

ttcctactgc acccatggag aatgtgcctt ttactgaaag naaatccaaa attcctgtaa      120

ggactatgcc cacttccacc ccagcacctc catctgcaga gtatgagagt tcagtttctg      180

aagattttct atccagtgta g                                                201


<210>  22
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  22

Asp Asp Asp Asp Lys 
1               5   


<210>  23
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Asp Ser Ser Ala Thr Ala Arg Phe Pro Gln Thr His Lys Glu Gln 
1               5                   10                  15      


Val Gln 
        


<210>  24
<211>  18
<212>  PRT
<213>  Canis familiaris

<400>  24

Gly Asp Ser Ser Ala Thr Glu Arg Phe Pro Gln Thr His Lys Glu Gln 
1               5                   10                  15      


Val Gln 
        


<210>  25
<211>  18
<212>  PRT
<213>  Rattus norvegicus

<400>  25

Gly Asp Ser Pro Ala Ala Ala Arg Ser Pro Gln Met His Gln Glu Ser 
1               5                   10                  15      


Val Gln 
        


<210>  26
<211>  18
<212>  PRT
<213>  Gallus gallus

<400>  26

Ala Glu Leu Ser Met Ala Glu Arg Leu Arg Gln Thr His Lys Glu Gln 
1               5                   10                  15      


Val Glu 
        


