                         SEQUENCE LISTING

<110>  Centre Nationale de la Recherche Medicale
 
<120>  BACILLUS PUMILUS BILIRUBIN OXIDASE AND APPLICATIONS THEREOF


<130>  CB/es F644-276 WO

<160>  6     

<170>  PatentIn version 3.4

<210>  1
<211>  1593
<212>  DNA
<213>  Bacillus pumilus


<220>
<221>  CDS
<222>  (1)..(1593)

<400>  1
atg gct agc atg act ggt gga cag caa atg ggt cgc gga tcc atg aac       48
Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Gly Ser Met Asn         
1               5                   10                  15              

cta gaa aaa ttt gtt gac gag ctg cca att cca gaa gtt gcg gag ccc       96
Leu Glu Lys Phe Val Asp Glu Leu Pro Ile Pro Glu Val Ala Glu Pro         
            20                  25                  30                  

gtc aaa aag aac cca aga caa aca tat tat gaa atc gct atg gag gag      144
Val Lys Lys Asn Pro Arg Gln Thr Tyr Tyr Glu Ile Ala Met Glu Glu         
        35                  40                  45                      

gta ttt cta aaa gtt cat aga gac ctg ccc cca acc aaa cta tgg acc      192
Val Phe Leu Lys Val His Arg Asp Leu Pro Pro Thr Lys Leu Trp Thr         
    50                  55                  60                          

tat aat ggc agt ttg cct ggt cca acc att cat gca aat cga aat gaa      240
Tyr Asn Gly Ser Leu Pro Gly Pro Thr Ile His Ala Asn Arg Asn Glu         
65                  70                  75                  80          

aaa gtt aaa gtg aaa tgg atg aac aaa ttg cca ctt aaa cat ttt cta      288
Lys Val Lys Val Lys Trp Met Asn Lys Leu Pro Leu Lys His Phe Leu         
                85                  90                  95              

ccg gtc gat cac acg att cac gaa ggc cat cat gat gaa cca gaa gtc      336
Pro Val Asp His Thr Ile His Glu Gly His His Asp Glu Pro Glu Val         
            100                 105                 110                 

aag acc gtc gtt cat tta cat ggc ggc gtc aca cca gca agc agt gac      384
Lys Thr Val Val His Leu His Gly Gly Val Thr Pro Ala Ser Ser Asp         
        115                 120                 125                     

ggc tat cca gag gct tgg ttt tca cga gac ttt gaa gca acc ggc ccc      432
Gly Tyr Pro Glu Ala Trp Phe Ser Arg Asp Phe Glu Ala Thr Gly Pro         
    130                 135                 140                         

ttc ttt gaa cgg gaa gtg tac gaa tac cca aat cat cag caa gcc tgc      480
Phe Phe Glu Arg Glu Val Tyr Glu Tyr Pro Asn His Gln Gln Ala Cys         
145                 150                 155                 160         

aca ttg tgg tat cac gat cat gcg atg gca ttg aca cga tta aat gtg      528
Thr Leu Trp Tyr His Asp His Ala Met Ala Leu Thr Arg Leu Asn Val         
                165                 170                 175             

tac gcc gga tta gct gga ttt tat ttg atc tca gat gcg ttt gaa aaa      576
Tyr Ala Gly Leu Ala Gly Phe Tyr Leu Ile Ser Asp Ala Phe Glu Lys         
            180                 185                 190                 

tca cta gaa tta ccg aag gat gag tat gat att ccg cta atg atc atg      624
Ser Leu Glu Leu Pro Lys Asp Glu Tyr Asp Ile Pro Leu Met Ile Met         
        195                 200                 205                     

gac cgt acg ttt caa gag gat ggc gcg ctg ttt tat cca agc aga cca      672
Asp Arg Thr Phe Gln Glu Asp Gly Ala Leu Phe Tyr Pro Ser Arg Pro         
    210                 215                 220                         

aac aac acg cca gaa gac agt gat cta cca gat ccg tct atc gtg ccc      720
Asn Asn Thr Pro Glu Asp Ser Asp Leu Pro Asp Pro Ser Ile Val Pro         
225                 230                 235                 240         

ttc ttt tgc gga gaa acc att ttg gtc aat gga aaa gta tgg cca tat      768
Phe Phe Cys Gly Glu Thr Ile Leu Val Asn Gly Lys Val Trp Pro Tyr         
                245                 250                 255             

tta gaa gta gaa cca cga aaa tac cgt ttt cgt att tta aat gcg tct      816
Leu Glu Val Glu Pro Arg Lys Tyr Arg Phe Arg Ile Leu Asn Ala Ser         
            260                 265                 270                 

aat aca aga act tac gag ctg cat cta gac aac gat gcg acg att ttg      864
Asn Thr Arg Thr Tyr Glu Leu His Leu Asp Asn Asp Ala Thr Ile Leu         
        275                 280                 285                     

caa att gga tct gat ggc ggc ttt tta cca aga cct gtt cac cat caa      912
Gln Ile Gly Ser Asp Gly Gly Phe Leu Pro Arg Pro Val His His Gln         
    290                 295                 300                         

tcc ttt acc att gct cct gct gaa cga ttt gat gtg atc att gat ttt      960
Ser Phe Thr Ile Ala Pro Ala Glu Arg Phe Asp Val Ile Ile Asp Phe         
305                 310                 315                 320         

tca gct tac gaa aac aaa acg atc acc ctt aaa aat aaa gct ggc tgc     1008
Ser Ala Tyr Glu Asn Lys Thr Ile Thr Leu Lys Asn Lys Ala Gly Cys         
                325                 330                 335             

gga cag gaa gta aat cct gaa aca gat gcc aac atc atg caa ttt aaa     1056
Gly Gln Glu Val Asn Pro Glu Thr Asp Ala Asn Ile Met Gln Phe Lys         
            340                 345                 350                 

gtc aca cgt cca cta aaa ggg aga gca cct aaa aca tta cgg cct ata     1104
Val Thr Arg Pro Leu Lys Gly Arg Ala Pro Lys Thr Leu Arg Pro Ile         
        355                 360                 365                     

ttc aaa ccg ctt cca cca ctt cga cct agt cgc gct gat caa gag cgt     1152
Phe Lys Pro Leu Pro Pro Leu Arg Pro Ser Arg Ala Asp Gln Glu Arg         
    370                 375                 380                         

acg ctc act ctt act ggt aca cag gat aaa tac ggt cgc cct att tta     1200
Thr Leu Thr Leu Thr Gly Thr Gln Asp Lys Tyr Gly Arg Pro Ile Leu         
385                 390                 395                 400         

ttg ctt gat aac cat ttt tgg aat gac cct gtc acg gaa aat cct cgg     1248
Leu Leu Asp Asn His Phe Trp Asn Asp Pro Val Thr Glu Asn Pro Arg         
                405                 410                 415             

ctt ggc agt gta gag gtt tgg tcc atc gtc aat cca aca agg ggc aca     1296
Leu Gly Ser Val Glu Val Trp Ser Ile Val Asn Pro Thr Arg Gly Thr         
            420                 425                 430                 

cat ccc att cat tta cat ctt gtt caa ttt agg gtg ata gac aga aga     1344
His Pro Ile His Leu His Leu Val Gln Phe Arg Val Ile Asp Arg Arg         
        435                 440                 445                     

cca ttt gat aca gag gtc tat caa tcg aca ggg gac att gtg tat aca     1392
Pro Phe Asp Thr Glu Val Tyr Gln Ser Thr Gly Asp Ile Val Tyr Thr         
    450                 455                 460                         

gga ccg aac gaa gcc cct cct tta cat gaa caa ggc tac aag gac acc     1440
Gly Pro Asn Glu Ala Pro Pro Leu His Glu Gln Gly Tyr Lys Asp Thr         
465                 470                 475                 480         

att caa gcg cat gcc ggt gaa gtc att cga atc att gct cgc ttt gtt     1488
Ile Gln Ala His Ala Gly Glu Val Ile Arg Ile Ile Ala Arg Phe Val         
                485                 490                 495             

cca tac agc ggc agg tac gtg tgg cat tgt cat ata tta gag cac gag     1536
Pro Tyr Ser Gly Arg Tyr Val Trp His Cys His Ile Leu Glu His Glu         
            500                 505                 510                 

gat tat gac atg atg agg ccg atg gat att att ctc gag cac cac cac     1584
Asp Tyr Asp Met Met Arg Pro Met Asp Ile Ile Leu Glu His His His         
        515                 520                 525                     

cac cac cac                                                         1593
His His His                                                             
    530                                                                 


<210>  2
<211>  531
<212>  PRT
<213>  Bacillus pumilus

<400>  2

Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Gly Ser Met Asn 
1               5                   10                  15      


Leu Glu Lys Phe Val Asp Glu Leu Pro Ile Pro Glu Val Ala Glu Pro 
            20                  25                  30          


Val Lys Lys Asn Pro Arg Gln Thr Tyr Tyr Glu Ile Ala Met Glu Glu 
        35                  40                  45              


Val Phe Leu Lys Val His Arg Asp Leu Pro Pro Thr Lys Leu Trp Thr 
    50                  55                  60                  


Tyr Asn Gly Ser Leu Pro Gly Pro Thr Ile His Ala Asn Arg Asn Glu 
65                  70                  75                  80  


Lys Val Lys Val Lys Trp Met Asn Lys Leu Pro Leu Lys His Phe Leu 
                85                  90                  95      


Pro Val Asp His Thr Ile His Glu Gly His His Asp Glu Pro Glu Val 
            100                 105                 110         


Lys Thr Val Val His Leu His Gly Gly Val Thr Pro Ala Ser Ser Asp 
        115                 120                 125             


Gly Tyr Pro Glu Ala Trp Phe Ser Arg Asp Phe Glu Ala Thr Gly Pro 
    130                 135                 140                 


Phe Phe Glu Arg Glu Val Tyr Glu Tyr Pro Asn His Gln Gln Ala Cys 
145                 150                 155                 160 


Thr Leu Trp Tyr His Asp His Ala Met Ala Leu Thr Arg Leu Asn Val 
                165                 170                 175     


Tyr Ala Gly Leu Ala Gly Phe Tyr Leu Ile Ser Asp Ala Phe Glu Lys 
            180                 185                 190         


Ser Leu Glu Leu Pro Lys Asp Glu Tyr Asp Ile Pro Leu Met Ile Met 
        195                 200                 205             


Asp Arg Thr Phe Gln Glu Asp Gly Ala Leu Phe Tyr Pro Ser Arg Pro 
    210                 215                 220                 


Asn Asn Thr Pro Glu Asp Ser Asp Leu Pro Asp Pro Ser Ile Val Pro 
225                 230                 235                 240 


Phe Phe Cys Gly Glu Thr Ile Leu Val Asn Gly Lys Val Trp Pro Tyr 
                245                 250                 255     


Leu Glu Val Glu Pro Arg Lys Tyr Arg Phe Arg Ile Leu Asn Ala Ser 
            260                 265                 270         


Asn Thr Arg Thr Tyr Glu Leu His Leu Asp Asn Asp Ala Thr Ile Leu 
        275                 280                 285             


Gln Ile Gly Ser Asp Gly Gly Phe Leu Pro Arg Pro Val His His Gln 
    290                 295                 300                 


Ser Phe Thr Ile Ala Pro Ala Glu Arg Phe Asp Val Ile Ile Asp Phe 
305                 310                 315                 320 


Ser Ala Tyr Glu Asn Lys Thr Ile Thr Leu Lys Asn Lys Ala Gly Cys 
                325                 330                 335     


Gly Gln Glu Val Asn Pro Glu Thr Asp Ala Asn Ile Met Gln Phe Lys 
            340                 345                 350         


Val Thr Arg Pro Leu Lys Gly Arg Ala Pro Lys Thr Leu Arg Pro Ile 
        355                 360                 365             


Phe Lys Pro Leu Pro Pro Leu Arg Pro Ser Arg Ala Asp Gln Glu Arg 
    370                 375                 380                 


Thr Leu Thr Leu Thr Gly Thr Gln Asp Lys Tyr Gly Arg Pro Ile Leu 
385                 390                 395                 400 


Leu Leu Asp Asn His Phe Trp Asn Asp Pro Val Thr Glu Asn Pro Arg 
                405                 410                 415     


Leu Gly Ser Val Glu Val Trp Ser Ile Val Asn Pro Thr Arg Gly Thr 
            420                 425                 430         


His Pro Ile His Leu His Leu Val Gln Phe Arg Val Ile Asp Arg Arg 
        435                 440                 445             


Pro Phe Asp Thr Glu Val Tyr Gln Ser Thr Gly Asp Ile Val Tyr Thr 
    450                 455                 460                 


Gly Pro Asn Glu Ala Pro Pro Leu His Glu Gln Gly Tyr Lys Asp Thr 
465                 470                 475                 480 


Ile Gln Ala His Ala Gly Glu Val Ile Arg Ile Ile Ala Arg Phe Val 
                485                 490                 495     


Pro Tyr Ser Gly Arg Tyr Val Trp His Cys His Ile Leu Glu His Glu 
            500                 505                 510         


Asp Tyr Asp Met Met Arg Pro Met Asp Ile Ile Leu Glu His His His 
        515                 520                 525             


His His His 
    530     


<210>  3
<211>  36
<212>  DNA
<213>  Bacillus pumilus

<400>  3
catggatcca tgaacctaga aaaatttgtt gacgag                               36


<210>  4
<211>  36
<212>  DNA
<213>  Bacillus pumilus

<400>  4
tacctcgaga ataatatcca tcggcctcat catgtc                               36


<210>  5
<211>  1530
<212>  DNA
<213>  Bacillus pumilus


<220>
<221>  CDS
<222>  (1)..(1530)

<400>  5
atg aac cta gaa aaa ttt gtt gac gag ctg cca att cca gaa gtt gcg       48
Met Asn Leu Glu Lys Phe Val Asp Glu Leu Pro Ile Pro Glu Val Ala         
1               5                   10                  15              

aag ccc gtc aaa aag aac cca aaa caa acg tat tat gaa atc gct atg       96
Lys Pro Val Lys Lys Asn Pro Lys Gln Thr Tyr Tyr Glu Ile Ala Met         
            20                  25                  30                  

gag gag gta ttt cta aaa gtt cat aga gat ctg ccc cca acc aag cta      144
Glu Glu Val Phe Leu Lys Val His Arg Asp Leu Pro Pro Thr Lys Leu         
        35                  40                  45                      

tgg acc tat aat ggc agt ttg cct ggt cca acc att cat gcg aat cga      192
Trp Thr Tyr Asn Gly Ser Leu Pro Gly Pro Thr Ile His Ala Asn Arg         
    50                  55                  60                          

aat gaa aaa gtc aaa gtg aaa tgg atg aac aaa ttg cca ctt aag cat      240
Asn Glu Lys Val Lys Val Lys Trp Met Asn Lys Leu Pro Leu Lys His         
65                  70                  75                  80          

ttt cta ccg gtc gat cac acc att cac gaa ggc cat cat gat gaa cca      288
Phe Leu Pro Val Asp His Thr Ile His Glu Gly His His Asp Glu Pro         
                85                  90                  95              

gaa gtt aaa acc gtc gtt cat tta cat ggt ggc gtc aca cca gca agc      336
Glu Val Lys Thr Val Val His Leu His Gly Gly Val Thr Pro Ala Ser         
            100                 105                 110                 

agt gat ggc tat cca gag gct tgg ttt tca cga gac ttt gaa gca acc      384
Ser Asp Gly Tyr Pro Glu Ala Trp Phe Ser Arg Asp Phe Glu Ala Thr         
        115                 120                 125                     

ggc ccc ttc ttt gaa cgg gag gtg tac gaa tac cca aat cat cag caa      432
Gly Pro Phe Phe Glu Arg Glu Val Tyr Glu Tyr Pro Asn His Gln Gln         
    130                 135                 140                         

gcc tgc aca ttg tgg tat cac gat cat gcg atg gca ttg aca cga tta      480
Ala Cys Thr Leu Trp Tyr His Asp His Ala Met Ala Leu Thr Arg Leu         
145                 150                 155                 160         

aat gtg tat gcc ggc tta gct gga ttt tat ttg atc tca gat gcg ttt      528
Asn Val Tyr Ala Gly Leu Ala Gly Phe Tyr Leu Ile Ser Asp Ala Phe         
                165                 170                 175             

gaa aag tcg cta gaa tta ccg aag ggt gag tat gat att ccg cta atg      576
Glu Lys Ser Leu Glu Leu Pro Lys Gly Glu Tyr Asp Ile Pro Leu Met         
            180                 185                 190                 

atc atg gac cgt acg ttt cag gag gat ggc gca ctg ttt tat cca agc      624
Ile Met Asp Arg Thr Phe Gln Glu Asp Gly Ala Leu Phe Tyr Pro Ser         
        195                 200                 205                     

agg cca aac aac aca cca gaa gac agt gac ata cca gat ccg tct atc      672
Arg Pro Asn Asn Thr Pro Glu Asp Ser Asp Ile Pro Asp Pro Ser Ile         
    210                 215                 220                         

gtg cct ttc ttt tgc gga gaa acc att ttg gtc aat gga aaa gta tgg      720
Val Pro Phe Phe Cys Gly Glu Thr Ile Leu Val Asn Gly Lys Val Trp         
225                 230                 235                 240         

ccg tat tta gaa gta gag ccg cga aaa tat cgt ttt cgt att tta aat      768
Pro Tyr Leu Glu Val Glu Pro Arg Lys Tyr Arg Phe Arg Ile Leu Asn         
                245                 250                 255             

gct tcc aat aca aga act tac gag ctg cat cta gac aac gat gcg acg      816
Ala Ser Asn Thr Arg Thr Tyr Glu Leu His Leu Asp Asn Asp Ala Thr         
            260                 265                 270                 

att ttg caa att gga tct gat ggc ggc ttt tta cca aga cct gtt cac      864
Ile Leu Gln Ile Gly Ser Asp Gly Gly Phe Leu Pro Arg Pro Val His         
        275                 280                 285                     

cat caa tcc ttt agc att gct cct gct gaa cga ttt gat gtc atc atc      912
His Gln Ser Phe Ser Ile Ala Pro Ala Glu Arg Phe Asp Val Ile Ile         
    290                 295                 300                         

gat ttt tca gct tac gaa aac aaa acg atc acc ctt aaa aat aaa gcc      960
Asp Phe Ser Ala Tyr Glu Asn Lys Thr Ile Thr Leu Lys Asn Lys Ala         
305                 310                 315                 320         

ggc tgc gga cag gaa gta aat cct gaa aca gat gca aac atc atg caa     1008
Gly Cys Gly Gln Glu Val Asn Pro Glu Thr Asp Ala Asn Ile Met Gln         
                325                 330                 335             

ttt aaa gtc act cga ccg cta aaa ggg aga gca cct aaa aca tta cgg     1056
Phe Lys Val Thr Arg Pro Leu Lys Gly Arg Ala Pro Lys Thr Leu Arg         
            340                 345                 350                 

cct att ttc aaa ccg ctt cca cca ctt cgg cct tgt cga gct gat aaa     1104
Pro Ile Phe Lys Pro Leu Pro Pro Leu Arg Pro Cys Arg Ala Asp Lys         
        355                 360                 365                     

gag cgt acg ctc act ctt acc ggt aca cag gat aaa tac ggc cgt cct     1152
Glu Arg Thr Leu Thr Leu Thr Gly Thr Gln Asp Lys Tyr Gly Arg Pro         
    370                 375                 380                         

att tta ttg cta gat aac caa ttt tgg aat gac cct gtc acg gaa aat     1200
Ile Leu Leu Leu Asp Asn Gln Phe Trp Asn Asp Pro Val Thr Glu Asn         
385                 390                 395                 400         

cct cgt ctt ggc agt gtg gag gtt tgg tct atc gtc aat cca aca agg     1248
Pro Arg Leu Gly Ser Val Glu Val Trp Ser Ile Val Asn Pro Thr Arg         
                405                 410                 415             

ggc aca cat cct att cat tta cac ctt gtt caa ttc aga gtg ata gac     1296
Gly Thr His Pro Ile His Leu His Leu Val Gln Phe Arg Val Ile Asp         
            420                 425                 430                 

aga aga cca ttt gat act gag gtc tat caa tcg aca ggg gac att gtg     1344
Arg Arg Pro Phe Asp Thr Glu Val Tyr Gln Ser Thr Gly Asp Ile Val         
        435                 440                 445                     

tat aca gga cca aac gaa gca cct ccc tta cat gaa caa ggc tac aag     1392
Tyr Thr Gly Pro Asn Glu Ala Pro Pro Leu His Glu Gln Gly Tyr Lys         
    450                 455                 460                         

gac acc att caa gcg cat gcc ggt gaa gtc att cgg atc atc gct cgc     1440
Asp Thr Ile Gln Ala His Ala Gly Glu Val Ile Arg Ile Ile Ala Arg         
465                 470                 475                 480         

ttt gtt cca tac agc ggc agg tat gtg tgg cat tgt cat ata tta gag     1488
Phe Val Pro Tyr Ser Gly Arg Tyr Val Trp His Cys His Ile Leu Glu         
                485                 490                 495             

cac gag gat tat gac atg atg cgg ccg atg gat atc atc cag             1530
His Glu Asp Tyr Asp Met Met Arg Pro Met Asp Ile Ile Gln                 
            500                 505                 510                 


<210>  6
<211>  510
<212>  PRT
<213>  Bacillus pumilus

<400>  6

Met Asn Leu Glu Lys Phe Val Asp Glu Leu Pro Ile Pro Glu Val Ala 
1               5                   10                  15      


Lys Pro Val Lys Lys Asn Pro Lys Gln Thr Tyr Tyr Glu Ile Ala Met 
            20                  25                  30          


Glu Glu Val Phe Leu Lys Val His Arg Asp Leu Pro Pro Thr Lys Leu 
        35                  40                  45              


Trp Thr Tyr Asn Gly Ser Leu Pro Gly Pro Thr Ile His Ala Asn Arg 
    50                  55                  60                  


Asn Glu Lys Val Lys Val Lys Trp Met Asn Lys Leu Pro Leu Lys His 
65                  70                  75                  80  


Phe Leu Pro Val Asp His Thr Ile His Glu Gly His His Asp Glu Pro 
                85                  90                  95      


Glu Val Lys Thr Val Val His Leu His Gly Gly Val Thr Pro Ala Ser 
            100                 105                 110         


Ser Asp Gly Tyr Pro Glu Ala Trp Phe Ser Arg Asp Phe Glu Ala Thr 
        115                 120                 125             


Gly Pro Phe Phe Glu Arg Glu Val Tyr Glu Tyr Pro Asn His Gln Gln 
    130                 135                 140                 


Ala Cys Thr Leu Trp Tyr His Asp His Ala Met Ala Leu Thr Arg Leu 
145                 150                 155                 160 


Asn Val Tyr Ala Gly Leu Ala Gly Phe Tyr Leu Ile Ser Asp Ala Phe 
                165                 170                 175     


Glu Lys Ser Leu Glu Leu Pro Lys Gly Glu Tyr Asp Ile Pro Leu Met 
            180                 185                 190         


Ile Met Asp Arg Thr Phe Gln Glu Asp Gly Ala Leu Phe Tyr Pro Ser 
        195                 200                 205             


Arg Pro Asn Asn Thr Pro Glu Asp Ser Asp Ile Pro Asp Pro Ser Ile 
    210                 215                 220                 


Val Pro Phe Phe Cys Gly Glu Thr Ile Leu Val Asn Gly Lys Val Trp 
225                 230                 235                 240 


Pro Tyr Leu Glu Val Glu Pro Arg Lys Tyr Arg Phe Arg Ile Leu Asn 
                245                 250                 255     


Ala Ser Asn Thr Arg Thr Tyr Glu Leu His Leu Asp Asn Asp Ala Thr 
            260                 265                 270         


Ile Leu Gln Ile Gly Ser Asp Gly Gly Phe Leu Pro Arg Pro Val His 
        275                 280                 285             


His Gln Ser Phe Ser Ile Ala Pro Ala Glu Arg Phe Asp Val Ile Ile 
    290                 295                 300                 


Asp Phe Ser Ala Tyr Glu Asn Lys Thr Ile Thr Leu Lys Asn Lys Ala 
305                 310                 315                 320 


Gly Cys Gly Gln Glu Val Asn Pro Glu Thr Asp Ala Asn Ile Met Gln 
                325                 330                 335     


Phe Lys Val Thr Arg Pro Leu Lys Gly Arg Ala Pro Lys Thr Leu Arg 
            340                 345                 350         


Pro Ile Phe Lys Pro Leu Pro Pro Leu Arg Pro Cys Arg Ala Asp Lys 
        355                 360                 365             


Glu Arg Thr Leu Thr Leu Thr Gly Thr Gln Asp Lys Tyr Gly Arg Pro 
    370                 375                 380                 


Ile Leu Leu Leu Asp Asn Gln Phe Trp Asn Asp Pro Val Thr Glu Asn 
385                 390                 395                 400 


Pro Arg Leu Gly Ser Val Glu Val Trp Ser Ile Val Asn Pro Thr Arg 
                405                 410                 415     


Gly Thr His Pro Ile His Leu His Leu Val Gln Phe Arg Val Ile Asp 
            420                 425                 430         


Arg Arg Pro Phe Asp Thr Glu Val Tyr Gln Ser Thr Gly Asp Ile Val 
        435                 440                 445             


Tyr Thr Gly Pro Asn Glu Ala Pro Pro Leu His Glu Gln Gly Tyr Lys 
    450                 455                 460                 


Asp Thr Ile Gln Ala His Ala Gly Glu Val Ile Arg Ile Ile Ala Arg 
465                 470                 475                 480 


Phe Val Pro Tyr Ser Gly Arg Tyr Val Trp His Cys His Ile Leu Glu 
                485                 490                 495     


His Glu Asp Tyr Asp Met Met Arg Pro Met Asp Ile Ile Gln 
            500                 505                 510 


