                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  Novel Peptides and Methods for Their Preparation and Use

<130>  X18982

<150>  US 61/317850
<151>  2010-03-26

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is alpha-amino isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is alpha-amino isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is 1-naphthylalanine or Phe

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is alpha-amino isobutyric acid

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  Gln at position 42 may be amidated when Xaa at positions 43 and 
       44 are absent

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa at position 43 is Cys or absent

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  Xaa at position 43 may be amidated when Xaa at position 44 is 
       absent

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  Xaa at position 43 may be PEGylated when it is Cys

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  Xaa at position 44 is Cys or absent

<220>
<221>  MOD_RES
<222>  (44)..(44)
<223>  Xaa at position 44 may be amidated

<220>
<221>  MOD_RES
<222>  (44)..(44)
<223>  Xaa at position 44 may be PEGylated when it is Cys

<400>  1

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Arg Ala Xaa Val Gln Trp Leu Ile Ala Xaa Lys Gly Lys 
            20                  25                  30          


Lys Gln Glu Trp Lys His Gln Ile Thr Gln Xaa Xaa 
        35                  40                  


<210>  2
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is alpha-amino isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is alpha-amino isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is alpha-amino isobutyric acid

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  Cys at position 43 is PEGylated with a PEG having an average 
       molecular weight of about 20 kDa

<220>
<221>  MOD_RES
<222>  (44)..(44)
<223>  Cys at position 44 is PEGylated with a PEG having an average 
       molecular weight of about 20 kDa

<220>
<221>  MOD_RES
<222>  (44)..(44)
<223>  Cys at position 44 is amidated

<400>  2

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Arg Ala Phe Val Gln Trp Leu Ile Ala Xaa Lys Gly Lys 
            20                  25                  30          


Lys Gln Glu Trp Lys His Gln Ile Thr Gln Cys Cys 
        35                  40                  


<210>  3
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is alpha-amino isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is alpha-amino isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is 1-naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is alpha-amino isobutyric acid

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  Cys at position 43 is PEGylated with a PEG having an average 
       molecular weight of about 20 kDa

<220>
<221>  MOD_RES
<222>  (44)..(44)
<223>  Cys at position 44 is PEGylated with a PEG having an average 
       molecular weight of about 20 kDa

<220>
<221>  MOD_RES
<222>  (44)..(44)
<223>  Cys at position 44 is amidated

<400>  3

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Arg Ala Xaa Val Gln Trp Leu Ile Ala Xaa Lys Gly Lys 
            20                  25                  30          


Lys Gln Glu Trp Lys His Gln Ile Thr Gln Cys Cys 
        35                  40                  


<210>  4
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is alpha-amino isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is alpha-amino isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is 1-naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is alpha-amino isobutyric acid

<400>  4

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Arg Ala Xaa Val Gln Trp Leu Ile Ala Xaa Lys Gly Lys 
            20                  25                  30          


Lys Gln Glu Trp Lys His Gln Ile Thr Gln 
        35                  40          


<210>  5
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is alpha-amino isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is alpha-amino isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is alpha-amino isobutyric acid

<400>  5

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Arg Ala Phe Val Gln Trp Leu Ile Ala Xaa Lys Gly Lys 
            20                  25                  30          


Lys Gln Glu Trp Lys His Gln Ile Thr Gln 
        35                  40          


<210>  6
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is alpha-amino isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is alpha-amino isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is 1-naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is alpha-amino isobutyric acid

<400>  6

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Arg Ala Xaa Val Gln Trp Leu Ile Ala Xaa Lys Gly Lys 
            20                  25                  30          


Lys Gln Glu Trp Lys His Gln Ile Thr Gln Cys Cys 
        35                  40                  


<210>  7
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is alpha-amino isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is alpha-amino isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is alpha-amino isobutyric acid

<400>  7

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Arg Ala Phe Val Gln Trp Leu Ile Ala Xaa Lys Gly Lys 
            20                  25                  30          


Lys Gln Glu Trp Lys His Gln Ile Thr Gln Cys Cys 
        35                  40                  


