                         SEQUENCE LISTING

<110>  Heinrich-Heine-Universitt Dsseldorf
 
<120>  Protein production in filamentous fungi

<130>  HHU13611PCT


<150>  EP 101582326.9
<151>  2010-03-29

<160>  10     

<170>  PatentIn version 3.5

<210>  1
<211>  1509
<212>  DNA
<213>  Ustilago maydis

<223>  cts1

<400>  1
atgtttggac gtcttaagca caggatgtct cgcgctcgac tagacgacga cggcaaaaag  60

tcatcgtcat ccgcttcatc gttgccacct tctccaacca aggcagcaac agcctctgct  120

gctggttcgg tccctcagac tccgactgct acggcacccg aagcttccac gccctcatcc  180

tcgacccaac ctgagtctcc cgtcgcttcg gcccccagca gcacttctcc tccgagtacg  240

acacctacca caccagcttc caacacaacc cctgcaagcg agatccaaaa caacatcgac  300

tcgcaaggtc acgatttcac caccaatggt gcggtcgtcc ctcgtgtcaa cctcgcctac  360

tttacaaact ggggtatcta cggtcgcaag tactctcctc tggacgttcc ttactgcaac  420

ctgacgcacg ttctctacgc tttcgccgac gtcaaccccg acaccggcga gtgcttcctc  480

accgatctct gggccgacga gcaaattcac tacactggcg actcctggaa cgatacgggt  540

aacaacctct acggcaactt taagcaattc cttttgctca agaagaagaa ccgtgcgctc  600

aagctcatgc tgtccgttgg tggatggaca tttggtccgc actttgcacc tatggcagcc  660

gacgccaaga agcgagccaa gtttgtctcg actgccatca cgattttgga gaacgacggg  720

ttggatggaa tcgacatcga ctgggagtat ccctcggaca gcacgcaagc tgccaacttt  780

gttctgctgc tcaaagagct tcgtgccggc ttgactgcac accaggccaa gaagaacgag  840

accaacccgt acctactgtc catcgctgcg ccctgtggac ctgaccatta caaggtgctc  900

caagtagcca agatggacca gtacctggat ttctggaacc tcatggcgta cgatttcgcc  960

ggttcgtggt ccgcactcac cggccaccaa gccaacctgt ggaacatcaa gggtgcaccg  1020

ccttcggccg acgattcgat caactactat attggccagg gcgtcgtttc gcacaagctc  1080

gttctcggaa tcccgctcta cggccgtggc ttcgaaaaca cggacggtcc acaacagccg  1140

tacaggggta cagggcaggg cacgtgggaa gccggcaact gggactacaa gtttttgcct  1200

gtcaaaggtg caaaggagat gatcaacacc aagatcgctg ctagttggag ttacgactca  1260

gccaagcgcg agttcattag ttacgacaca cctcagaacg tcttgttgaa gtgtcagtac  1320

atcaggaaca agaggttgag gggtgccatg ttctgggagc tgagtggtga cgcaaccaag  1380

agccagggtg gtgctgaaag gagtctcatc gccctcactg ccaagaacat gggcacactc  1440

gatgccactt tgaaccacat cagttaccct ttcagcaagt gggacaatgt caagaacggc  1500

ctcaagtaa                                                          1509


<210>  2
<211>  502
<212>  PRT
<213>  Ustilago maydis

<223>  Cts1

<400>  2

Met Phe Gly Arg Leu Lys His Arg Met Ser Arg Ala Arg Leu Asp Asp 
1               5                   10                  15      

Asp Gly Lys Lys Ser Ser Ser Ser Ala Ser Ser Leu Pro Pro Ser Pro 
            20                  25                  30          

Thr Lys Ala Ala Thr Ala Ser Ala Ala Gly Ser Val Pro Gln Thr Pro 
        35                  40                  45              

Thr Ala Thr Ala Pro Glu Ala Ser Thr Pro Ser Ser Ser Thr Gln Pro 
    50                  55                  60                  

Glu Ser Pro Val Ala Ser Ala Pro Ser Ser Thr Ser Pro Pro Ser Thr 
65                  70                  75                  80  

Thr Pro Thr Thr Pro Ala Ser Asn Thr Thr Pro Ala Ser Glu Ile Gln 
                85                  90                  95      

Asn Asn Ile Asp Ser Gln Gly His Asp Phe Thr Thr Asn Gly Ala Val 
            100                 105                 110         

Val Pro Arg Val Asn Leu Ala Tyr Phe Thr Asn Trp Gly Ile Tyr Gly 
        115                 120                 125             

Arg Lys Tyr Ser Pro Leu Asp Val Pro Tyr Cys Asn Leu Thr His Val 
    130                 135                 140                 

Leu Tyr Ala Phe Ala Asp Val Asn Pro Asp Thr Gly Glu Cys Phe Leu 
145                 150                 155                 160 

Thr Asp Leu Trp Ala Asp Glu Gln Ile His Tyr Thr Gly Asp Ser Trp 
                165                 170                 175     

Asn Asp Thr Gly Asn Asn Leu Tyr Gly Asn Phe Lys Gln Phe Leu Leu 
            180                 185                 190         

Leu Lys Lys Lys Asn Arg Ala Leu Lys Leu Met Leu Ser Val Gly Gly 
        195                 200                 205             

Trp Thr Phe Gly Pro His Phe Ala Pro Met Ala Ala Asp Ala Lys Lys 
    210                 215                 220                 

Arg Ala Lys Phe Val Ser Thr Ala Ile Thr Ile Leu Glu Asn Asp Gly 
225                 230                 235                 240 

Leu Asp Gly Ile Asp Ile Asp Trp Glu Tyr Pro Ser Asp Ser Thr Gln 
                245                 250                 255     

Ala Ala Asn Phe Val Leu Leu Leu Lys Glu Leu Arg Ala Gly Leu Thr 
            260                 265                 270         

Ala His Gln Ala Lys Lys Asn Glu Thr Asn Pro Tyr Leu Leu Ser Ile 
        275                 280                 285             

Ala Ala Pro Cys Gly Pro Asp His Tyr Lys Val Leu Gln Val Ala Lys 
    290                 295                 300                 

Met Asp Gln Tyr Leu Asp Phe Trp Asn Leu Met Ala Tyr Asp Phe Ala 
305                 310                 315                 320 

Gly Ser Trp Ser Ala Leu Thr Gly His Gln Ala Asn Leu Trp Asn Ile 
                325                 330                 335     

Lys Gly Ala Pro Pro Ser Ala Asp Asp Ser Ile Asn Tyr Tyr Ile Gly 
            340                 345                 350         

Gln Gly Val Val Ser His Lys Leu Val Leu Gly Ile Pro Leu Tyr Gly 
        355                 360                 365             

Arg Gly Phe Glu Asn Thr Asp Gly Pro Gln Gln Pro Tyr Arg Gly Thr 
    370                 375                 380                 

Gly Gln Gly Thr Trp Glu Ala Gly Asn Trp Asp Tyr Lys Phe Leu Pro 
385                 390                 395                 400 

Val Lys Gly Ala Lys Glu Met Ile Asn Thr Lys Ile Ala Ala Ser Trp 
                405                 410                 415     

Ser Tyr Asp Ser Ala Lys Arg Glu Phe Ile Ser Tyr Asp Thr Pro Gln 
            420                 425                 430         

Asn Val Leu Leu Lys Cys Gln Tyr Ile Arg Asn Lys Arg Leu Arg Gly 
        435                 440                 445             

Ala Met Phe Trp Glu Leu Ser Gly Asp Ala Thr Lys Ser Gln Gly Gly 
    450                 455                 460                 

Ala Glu Arg Ser Leu Ile Ala Leu Thr Ala Lys Asn Met Gly Thr Leu 
465                 470                 475                 480 

Asp Ala Thr Leu Asn His Ile Ser Tyr Pro Phe Ser Lys Trp Asp Asn 
                485                 490                 495     

Val Lys Asn Gly Leu Lys 
            500         


<210>  3
<211>  305
<212>  DNA
<213>  Ustilago maydis

<223>  3'end of the ubi gene

<400>  3
caagaagaag ttgaagtaag ctgtttcgct tttgctcgat tgcgattcgg atcttttggc  60

tcttggtttc ttctcaacac acacacacac acacacacac acacacacac acacacacac  120

acacacacac acgcacatct acatatatgc aacacatcgc acaccacaca tggcacagta  180

caagcattgc gcctgcgtgc tggagtgcac tggcctcgcg cctacaccca ctggctctga  240

cagcgctcgt ttgtctttgt cagttgtttc aaaaccacat gttattcttg gttgtgccgt  300

ctaga                                                              305


<210>  4
<211>  792
<212>  PRT
<213>  Ustilago maydis

<223>  Rrm4

<400>  4

Met Ser Asp Ser Ile Tyr Ala Pro His Asn Lys His Lys Leu Glu Ala 
1               5                   10                  15      

Ala Arg Ala Ala Asp Ala Ala Ala Asp Asp Ala Ala Thr Val Ser Ala 
            20                  25                  30          

Leu Val Glu Pro Thr Asp Ser Thr Ala Gln Ala Ser His Ala Ala Glu 
        35                  40                  45              

Gln Thr Ile Asp Ala His Gln Gln Ala Gly Asp Val Glu Pro Glu Arg 
    50                  55                  60                  

Cys His Pro His Leu Thr Arg Pro Leu Leu Tyr Leu Ser Gly Val Asp 
65                  70                  75                  80  

Ala Thr Met Thr Asp Lys Glu Leu Ala Gly Leu Val Phe Asp Gln Val 
                85                  90                  95      

Leu Pro Val Arg Leu Lys Ile Asp Arg Thr Val Gly Glu Gly Gln Thr 
            100                 105                 110         

Ala Ser Gly Thr Val Glu Phe Gln Thr Leu Asp Lys Ala Glu Lys Ala 
        115                 120                 125             

Tyr Ala Thr Val Arg Pro Pro Ile Gln Leu Arg Ile Asn Gln Asp Ala 
    130                 135                 140                 

Ser Ile Arg Glu Pro His Pro Ser Ala Lys Pro Arg Leu Val Lys Gln 
145                 150                 155                 160 

Leu Pro Pro Thr Ser Asp Asp Ala Phe Val Tyr Asp Leu Phe Arg Pro 
                165                 170                 175     

Phe Gly Pro Leu Arg Arg Ala Gln Cys Leu Leu Thr Asn Pro Ala Gly 
            180                 185                 190         

Ile His Thr Gly Phe Lys Gly Met Ala Val Leu Glu Phe Tyr Ser Glu 
        195                 200                 205             

Gln Asp Ala Gln Arg Ala Glu Ser Glu Met His Cys Ser Glu Val Gly 
    210                 215                 220                 

Gly Lys Ser Ile Ser Val Ala Ile Asp Thr Ala Thr Arg Lys Val Ser 
225                 230                 235                 240 

Ala Ala Ala Ala Glu Phe Arg Pro Ser Ala Ala Ala Phe Val Pro Ala 
                245                 250                 255     

Gly Ser Met Ser Pro Ser Ala Pro Ser Phe Asp Pro Tyr Pro Ala Gly 
            260                 265                 270         

Ser Arg Ser Val Ser Thr Gly Ser Ala Ala Ser Ile Tyr Ala Thr Ser 
        275                 280                 285             

Gly Ala Ala Pro Thr His Asp Thr Arg Asn Gly Ala Gln Lys Gly Ala 
    290                 295                 300                 

Arg Val Pro Leu Gln Tyr Ser Ser Gln Ala Ser Thr Tyr Val Asp Pro 
305                 310                 315                 320 

Cys Asn Leu Phe Ile Lys Asn Leu Asp Pro Asn Met Glu Ser Asn Asp 
                325                 330                 335     

Leu Phe Asp Thr Phe Lys Arg Phe Gly His Ile Val Ser Ala Arg Val 
            340                 345                 350         

Met Arg Asp Asp Asn Gly Lys Ser Arg Glu Phe Gly Phe Val Ser Phe 
        355                 360                 365             

Thr Thr Pro Asp Glu Ala Gln Gln Ala Leu Gln Ala Met Asp Asn Ala 
    370                 375                 380                 

Lys Leu Gly Thr Lys Lys Ile Ile Val Arg Leu His Glu Pro Lys Thr 
385                 390                 395                 400 

Met Arg Gln Glu Lys Leu Ala Ala Arg Tyr Asn Ala Ala Asn Ala Asp 
                405                 410                 415     

Asn Ser Asp Met Ser Ser Asn Ser Pro Pro Thr Glu Ala Arg Lys Ala 
            420                 425                 430         

Asp Lys Arg Gln Ser Arg Ser Tyr Phe Lys Ala Gly Val Pro Ser Asp 
        435                 440                 445             


Ala Ser Gly Leu Val Asp Glu Glu Gln Leu Arg Ser Leu Ser Thr Val 
    450                 455                 460                 

Val Arg Asn Glu Leu Leu Ser Gly Glu Phe Thr Arg Arg Ile Pro Lys 
465                 470                 475                 480 

Val Ser Ser Val Thr Glu Ala Gln Leu Asp Asp Val Val Gly Glu Leu 
                485                 490                 495     

Leu Ser Leu Lys Leu Ala Asp Ala Val Glu Ala Leu Asn Asn Pro Ile 
            500                 505                 510         

Ser Leu Ile Gln Arg Ile Ser Asp Ala Arg Glu Gln Leu Ala Gln Lys 
        515                 520                 525             

Ser Ala Ser Thr Leu Thr Ala Pro Ser Pro Ala Pro Leu Ser Ala Glu 
    530                 535                 540                 

His Pro Ala Met Leu Gly Ile Gln Ala Gln Arg Ser Val Ser Ser Ala 
545                 550                 555                 560 

Ser Ser Thr Gly Glu Gly Gly Ala Ser Val Lys Glu Arg Glu Arg Leu 
                565                 570                 575     

Leu Lys Ala Val Ile Ser Val Thr Glu Ser Gly Ala Pro Val Glu Asp 
            580                 585                 590         

Ile Thr Asp Met Ile Ala Ser Leu Pro Lys Lys Asp Arg Ala Leu Ala 
        595                 600                 605             

Leu Phe Asn Pro Glu Phe Leu Lys Gln Lys Val Asp Glu Ala Lys Asp 
    610                 615                 620                 

Ile Leu Asp Ile Thr Asp Glu Ser Gly Glu Asp Leu Ser Pro Pro Arg 
625                 630                 635                 640 

Ala Ser Ser Gly Ser Ala Pro Val Pro Leu Ser Val Gln Thr Pro Ala 
                645                 650                 655     

Ser Ala Ile Phe Lys Asp Ala Ser Asn Gly Gln Ser Ser Ile Ser Pro 
            660                 665                 670         

Gly Ala Ala Glu Ala Tyr Thr Leu Ser Thr Leu Ala Ala Leu Pro Ala 
        675                 680                 685             

Ala Glu Ile Val Arg Leu Ala Asn Ser Gln Ser Ser Ser Gly Leu Pro 
    690                 695                 700                 


Leu Pro Lys Ala Asp Pro Ala Thr Val Lys Ala Thr Asp Asp Phe Ile 
705                 710                 715                 720 


Asp Ser Leu Gln Gly Lys Ala Ala His Asp Gln Lys Gln Lys Leu Gly 
                725                 730                 735     

Asp Gln Leu Phe Lys Lys Ile Arg Thr Phe Gly Val Lys Gly Ala Pro 
            740                 745                 750         


Lys Leu Thr Ile His Leu Leu Asp Ser Glu Asp Leu Arg Ala Leu Ala 
        755                 760                 765             

His Leu Met Asn Ser Tyr Glu Asp Val Leu Lys Glu Lys Val Gln His 
    770                 775                 780                 

Lys Val Ala Ala Gly Leu Asn Lys 
785                 790         


<210>  5
<211>  2379
<212>  DNA
<213>  Ustilago maydis

<223>  rrm4

<400>  5
atgtccgatt cgatttacgc cccacataat aagcacaagc tcgaggcagc gcgagccgct  60

gatgctgccg ccgatgatgc cgccaccgtc agcgccctcg tcgagccgac cgactccact  120

gcgcaggcaa gtcacgctgc ggagcaaacc attgatgcgc atcagcaagc aggtgacgtc  180

gaacctgaac gatgccatcc tcacctcact cgccccttgc tctaccttag cggtgtcgat  240

gccaccatga ctgacaagga gctcgccggc cttgtctttg atcaagtact ccccgtccgg  300

ctcaaaattg accgcaccgt gggcgagggc cagacagcca gcggcaccgt cgagttccag  360

acgctggata aggccgagaa ggcttatgct accgttcgtc ctccgatcca gctgcgcatc  420

aaccaggacg cctccatcag agagccgcac ccctcggcca aaccacgtct tgtcaagcag  480

ctgccaccta catcggacga cgcgttcgta tacgacctct tccgtccttt cggtccgctc  540

cgacgagctc agtgtctgct caccaatcca gccggcattc acaccggctt caagggtatg  600

gccgtgcttg aattctactc tgaacaagac gcccagcgtg ccgaatccga gatgcactgc  660

agcgaagtcg gcggcaagtc gatctctgtt gccattgata ccgctacgcg caaggtcagc  720

gctgctgcag ccgagttccg tccctcggct gctgcattcg ttccagcggg cagcatgagt  780

ccgtcagctc cgtcctttga cccttaccct gctggctctc gttccgtttc gacaggctca  840

gccgcttcca tctacgcaac ttctggcgcc gctccgactc acgatacccg caacggtgct  900

cagaagggag cgcgtgttcc gctccagtat tcgagccaag catctacgta tgtcgaccct  960

tgcaacctct tcatcaagaa cctcgacccc aacatggaat ccaatgacct cttcgacacc  1020

ttcaaaaggt ttggccacat cgtctctgca cgcgtcatgc gcgacgataa cggcaagagc  1080

agagaatttg ggtttgtcag cttcaccact cctgacgaag cgcaacaagc tctacaagca  1140

atggacaatg ccaaacttgg caccaaaaag atcattgtcc gtctgcacga gcccaagacg  1200

atgcgtcagg agaagctcgc agcgcgttac aacgctgcca atgccgataa cagtgacatg  1260

agcagcaaca gtccgcccac agaggctcgc aaagccgaca agcgtcaaag cagaagctac  1320

ttcaaagcag gtgtgccttc ggatgccagc ggtcttgtag acgaagagca attgcgctcg  1380

ctcagcactg tcgtgagaaa cgagctcttg tctggcgaat ttacacgaag aatccccaag  1440

gtttcctcgg tcaccgaggc gcagttggac gacgttgtag gcgagctgct cagtctcaag  1500

cttgctgatg ccgtcgaggc gctcaataac ccaatttcgc ttattcaaag gatcagcgat  1560

gctcgcgagc agcttgcaca gaagtctgcc tccactctga cggctccgag tccggcgcca  1620

ctgtctgctg aacacccagc tatgctcggt attcaggctc agcgtagcgt atcaagcgca  1680

tcttcgaccg gcgaaggagg tgcgtcggtc aaggagaggg agaggctact caaggctgtc  1740

atctccgtca ccgaaagtgg tgcccccgtt gaggacatca ccgacatgat cgcaagcctg  1800

ccaaagaagg atcgtgccct tgcgctcttc aatccagagt ttctcaagca aaaagtggac  1860

gaagccaagg acattctcga catcaccgac gaaagtggcg aagatctttc gcctcctcgt  1920

gcttccagtg ggagcgctcc ggtgccattg tcagtgcaga cgcctgcttc tgctattttc  1980

aaagatgcca gcaacggcca gagctccatc tcgcctggcg ctgctgaggc ttacacatta  2040

tccacgcttg ctgcgcttcc tgcagccgag attgtgcgct tggccaactc ccaatccagc  2100

tccggtctgc ctctccctaa agcggatcca gcgacggtca aggcaaccga cgatttcatc  2160

gactcgcttc agggcaaagc agcgcacgat cagaagcaga agctgggtga tcagctcttc  2220

aaaaagatcc gtacgttcgg cgtcaaaggc gcacccaagc tcaccatcca cttgttggat  2280

tccgaagact tgcgggcgct ggcgcatctc atgaactcgt acgaggacgt gctcaaggaa  2340

aaagttcagc acaaggttgc tgcaggtctg aacaagtga                         2379


<210>  6
<211>  503
<212>  PRT
<213>  Sporisorium reilianum

<223>  Cts1

<400>  6

Met Phe Gly Arg Leu Lys His Lys Leu Ser Arg Arg Phe Asp Glu Asp 
1               5                   10                  15      

Lys Lys Ser Ser Ser Pro Ala Ser Ser Leu Pro Pro Ser Pro Thr Lys 
            20                  25                  30          

Pro Ala Ala Phe Ser Ala Ala Ala Thr Thr Ser Gly Ser Asn Thr Ala 
        35                  40                  45              

Ala Thr Thr Pro Ala Ala Pro Val Ile Asn Thr Pro Glu Ala Thr Lys 
    50                  55                  60                  

Pro Ser Ser Ser Thr Gly Gly Ala Thr Thr Pro Val Ala Thr Thr Pro 
65                  70                  75                  80  

Ser Thr Ala Pro Thr Thr Pro Pro Ala Thr Ser Val Asp His Asn Thr 
                85                  90                  95      

Asp Ser Gln Thr Thr Asp Ala Asp Gly His Asp Phe Thr Thr Asn Gly 
            100                 105                 110         

Ala Val Val Pro Arg Val Asn Leu Gly Tyr Phe Thr Asn Trp Gly Ile 
        115                 120                 125             

Tyr Gly Arg Lys Tyr Ser Pro Leu Asp Val Pro Ile Cys Asn Leu Thr 
    130                 135                 140                 

His Ile Leu Tyr Ala Phe Ala Asp Val Asn Pro Asp Thr Gly Glu Cys 
145                 150                 155                 160 

Ile Leu Thr Asp Leu Trp Ala Asp Glu Gln Leu His Tyr Thr Gly Asp 
                165                 170                 175     

Ser Trp Asn Asp Ala Gly Asn Asn Leu Tyr Gly Asn Phe Lys Gln Phe 
            180                 185                 190         

Leu Leu Leu Lys Lys Lys Asn Arg Ala Leu Lys Leu Met Leu Ser Val 
        195                 200                 205             

Gly Gly Trp Thr Phe Gly Pro His Phe Ala Pro Met Ala Ala Asp Ala 
    210                 215                 220                 

Lys Lys Arg Ala Lys Phe Val Ser Ser Ala Ile Thr Ile Leu Glu Asn 
225                 230                 235                 240 

Asp Gly Leu Asp Gly Ile Asp Ile Asp Trp Glu Tyr Pro Ala Asn Asp 
                245                 250                 255     

Ala Gln Ala Ala Asn Phe Val Leu Leu Leu Lys Glu Leu Arg Ala Gly 
            260                 265                 270         

Leu Thr Ala His Gln Lys Lys Lys Asn Asp Met Val Pro Tyr Leu Leu 
        275                 280                 285             

Ser Ile Ala Ala Pro Cys Gly Pro Asp His Tyr Lys Val Leu Gln Val 
    290                 295                 300                 

Ala Lys Met Asp Pro Tyr Leu Asp Phe Trp Asn Leu Met Ala Tyr Asp 
305                 310                 315                 320 

Phe Ala Gly Ser Trp Ser Thr Val Thr Gly His Gln Ala Asn Leu Trp 
                325                 330                 335     

Asn Ile Lys Gly Ala Pro Pro Ser Ala Asp Asp Ala Val Asn Tyr Tyr 
            340                 345                 350         

Ile Gly Asn Gly Val Val Ser His Lys Leu Val Leu Gly Ile Pro Leu 
        355                 360                 365             

Tyr Gly Arg Gly Phe Glu Asn Thr Asp Gly Pro Gln Gln Pro Tyr Lys 
    370                 375                 380                 


Gly Thr Gly Gln Gly Thr Trp Glu Ala Gly Asn Trp Asp Tyr Lys Phe 
385                 390                 395                 400 

Leu Pro Val Lys Gly Ala Lys Glu Met Ile Asn Thr Lys Ile Ala Ala 
                405                 410                 415     

Ser Trp Ser Tyr Asp Ser Ser Lys Arg Glu Phe Ile Ser Tyr Asp Thr 
            420                 425                 430         

Pro Gln Asn Val Leu Leu Lys Cys Ala Tyr Ile Lys Gln Lys Arg Leu 
        435                 440                 445             

Arg Gly Ala Met Phe Trp Glu Leu Ser Gly Asp Ala Thr Lys Ala Gln 
    450                 455                 460                 

Gly Gly Ala Asp Arg Ser Leu Val Ala Leu Thr Ala Lys Asn Met Gly 
465                 470                 475                 480 

Thr Leu Asp Thr Thr Leu Asn His Ile Ser Tyr Pro Tyr Ser Lys Trp 
                485                 490                 495     

Asp Asn Val Arg Ala Phe Lys 
            500             


<210>  7
<211>  774
<212>  PRT
<213>  Sporisorium reilianum

<223>  Rrm4

<400>  7

Met Ser Asp Ser Ile Tyr Ala Pro His Asn His Ala Lys Leu Gln Ala 
1               5                   10                  15      

Ala Arg Ala Ala Asp Ala Val Ala Ala Ala Thr Ala Thr Ala Ser Ala 
            20                  25                  30          

Pro Ala Ser Pro Thr Pro Glu Ala Val Pro Ala Pro Gln Gln Thr Asn 
        35                  40                  45              

Glu Asp Gly Leu Gln Arg Pro His Pro His Leu Thr Arg Pro Leu Leu 
    50                  55                  60                  

Tyr Ile Ser Gly Val Asp Ala Thr Met Thr Asp Lys Glu Leu Ala Gly 
65                  70                  75                  80  

Leu Val Phe Asp Gln Val Leu Pro Val Arg Leu Arg Ile Asp Arg Thr 
                85                  90                  95      

Val Ala Glu Gly Gln Thr Ala Ser Gly Thr Ile Glu Phe Gln Thr Leu 
            100                 105                 110         

Asp Lys Ala Glu Lys Ala Tyr Ala Thr Val Arg Pro Pro Ile Gln Leu 
        115                 120                 125             

Arg Ile Gln Gln Asp Ser Ser Ser Lys Glu Pro Thr Ala Ser Ala Lys 
    130                 135                 140                 

Pro Arg Leu Val Lys Gln Leu Pro Pro Gly Thr Asp Asp Ala Ser Leu 
145                 150                 155                 160 

Phe Asp Leu Phe Arg Pro Phe Gly Pro Leu Arg Arg Ala Gln Cys Leu 
                165                 170                 175     

Leu Thr Asn Pro Ala Gly Ile His Thr Gly Phe Lys Gly Arg Ala Met 
            180                 185                 190         

Leu Glu Phe Tyr Ser Glu Asp Asp Ala Gln Arg Ala Glu Ser Lys Met 
        195                 200                 205             

His Cys Arg Glu Leu Gly Gly Lys Ser Ile Ser Val Val Val Asp Thr 
    210                 215                 220                 

Asn Thr Arg Lys Val Ser Ala Ser Ala Ala Glu Phe Arg Pro Ser Ala 
225                 230                 235                 240 

Ala Pro Phe Val Pro Ala Ser Ser Gly Gly Met Ser Pro Ser Ala Pro 
                245                 250                 255     

Leu Phe Ala Pro Ser Ala Pro Gly Ser Arg Ser Val Ser Ala Gly Ser 
            260                 265                 270         

Ser Ala Ser Ile Tyr Ala Thr Ser Ser Ser Pro Ala Gln Lys Gly Ala 
        275                 280                 285             

Arg Gly Gln Leu Gln Tyr Ser Ser Gln Ala Ser Thr Phe Val Asp Pro 
    290                 295                 300                 

Cys Asn Leu Phe Ile Lys Asn Leu Asp Ala Asp Ile Glu Ser Lys Asp 
305                 310                 315                 320 

Leu Tyr Asp Thr Phe Lys Ala Phe Gly His Ile Val Ser Ala Arg Val 
                325                 330                 335     

Met Arg Asp Asn Asp Gly Lys Ser Arg Glu Phe Gly Phe Val Ser Phe 
            340                 345                 350         

Lys Val Ala Glu Asp Ala Thr Gln Ala Leu His Ala Met Asp Asn Ala 
        355                 360                 365             

Lys Leu Gly Ser Lys Lys Ile Thr Val Arg Leu His Glu Pro Lys Thr 
    370                 375                 380                 


Met Arg Gln Glu Lys Leu Ala Ala Arg Phe Asn Ala Ala Asn Ala Glu 
385                 390                 395                 400 

Ser Ala Asp Ala Gly Ser Ala Gly Ser Ser Val Asp Gly Arg Asp Asn 
                405                 410                 415     

Glu Thr Ser Arg Lys Thr Asp Lys Arg Gln Ser Arg Ser Tyr Phe Lys 
            420                 425                 430         

Ala Gly Val Pro Ala Asp Ala Asn Gly Leu Ala Asp Glu Glu Gln Leu 
        435                 440                 445             

Arg Ser Leu Ser Ser Val Val Arg Asn Glu Leu Leu Ser Gly Glu Phe 
    450                 455                 460                 

Thr Arg Arg Val Gln Gln Val Pro Ser Ile Asp Glu Ala His Val Asp 
465                 470                 475                 480 

Gly Val Val Ser Ala Leu Leu Lys Leu Lys Leu Gly Asp Ala Val Glu 
                485                 490                 495     

Ala Leu Asn Asn Pro Ile Ser Leu Ile Gln Arg Val Asn Asp Ala Arg 
            500                 505                 510         

Glu Gln Leu Ala Gln Ser Pro Ala Pro Ala Ser Met Gln Ala Pro Ser 
        515                 520                 525             

Met Leu Gly Ala Gln Asn Pro Ala Met Leu Gly Val Gln Ala Gln Arg 
    530                 535                 540                 

Ser Val Ser Ser Thr Ser Ser Asn Gly Glu Gly Gly Ala Ser Ser Lys 
545                 550                 555                 560 

Glu Arg Glu Arg Leu Leu Lys Ala Val Arg Ser Val Ala Glu Ala Asp 
                565                 570                 575     

Ala Pro Val Glu Asp Ile Thr Asp Met Leu Ala Ser Leu Pro Lys Lys 
            580                 585                 590         

Asp Arg Ala Leu Ala Leu Phe Asn Pro Glu Phe Leu Lys Gln Lys Val 
        595                 600                 605             

Asp Glu Ala Lys Asp Ile Leu Asp Ile Thr Asp Asp Ser Gly Glu Asp 
    610                 615                 620                 

Leu Ser Pro Pro Pro Ala Gly Asn Gly Ser Ser Ala Val Ala Ala Pro 
625                 630                 635                 640 

Ala Val Leu Lys Asp Ala Ser Asn Gly Gln Asp Ser Thr Ser Ala Thr 
                645                 650                 655     

Ala Gln Thr His Thr Leu Ser Ser Leu Ala Ala Leu Pro Ala Val Glu 
            660                 665                 670         

Ile Val Arg Leu Ala Asn Ser Pro Ser Ser Ala Gly Leu Pro Leu Ala 
        675                 680                 685             

Lys Pro Asp Ala Glu Thr Val Ala Ala Thr Asp Ala Phe Ile Asp Ser 
    690                 695                 700                 

Leu Gln Gly Lys Ala Ala His Asp Gln Lys Gln Lys Leu Gly Asp Gln 
705                 710                 715                 720 

Leu Phe Lys Lys Val Arg Ser Phe Gly Val Lys Gly Ala Pro Lys Leu 
                725                 730                 735     

Thr Ile His Leu Leu Asp Ser Glu Glu Leu Arg Ala Leu Ala His Leu 
            740                 745                 750         

Met Asn Ser Tyr Glu Asp Val Leu Arg Glu Lys Val Gln Gln Lys Val 
        755                 760                 765             

Val Ala Gly Leu Asn Lys 
    770                 


<210>  8
<211>  840
<212>  PRT
<213>  Coprinopsis cinerea

<223>  Rrm4

<400>  8

Met Asp Ala Asp Tyr Ser Ala Ala Gly Pro Pro Ser Gln Glu Glu His 
1               5                   10                  15      

Ser Pro Gln Pro His Pro Tyr Leu His Glu Pro Leu Leu Tyr Ile Thr 
            20                  25                  30          

Asn Leu Pro Ala Phe Val Thr Asp Glu Met Leu Ala Val Ala Phe Met 
        35                  40                  45              

Tyr Cys Gly Pro Phe Arg Pro Lys Ile Gln Arg Asn Thr Pro Ser Gly 
    50                  55                  60                  

Thr Leu Ser Gly Thr Ile Glu Phe Lys Phe Leu Glu Lys Ala Glu Lys 
65                  70                  75                  80  

Ala Leu Ala Thr Leu His Asn Arg Pro Ile Pro Glu Val Pro Gln Asn 
                85                  90                  95      

Val Ile Leu Val Leu Ser Pro Tyr Pro Pro Thr Asn Pro Pro Thr Pro 
            100                 105                 110         

Leu Pro Pro Pro Ser Ala Leu Pro Arg Leu Val Lys Gln Leu Pro Gln 
        115                 120                 125             

Gly Tyr Thr Asp Ser Gln Leu Tyr Asp Leu Phe Arg Pro Tyr Gly Ala 
    130                 135                 140                 

Leu Ala Ser Ala Arg Thr Gln Thr Pro Phe Gly Pro Asp Thr Gly Met 
145                 150                 155                 160 

Val Glu Phe Trp Asn Glu Asn Asp Ala Arg Thr Ala Glu Glu Ala Leu 
                165                 170                 175     

His Cys Ala Glu Val Glu Gly Gln Asn Ile Ala Val Gln Ile Tyr Gln 
            180                 185                 190         

Gln Pro Arg Arg Thr Ser Ala Ser Phe Ser Glu Phe Asn Pro Ser Ala 
        195                 200                 205             

Ala Ala Phe Val Pro Ser Gly Ser Phe Phe Ser Pro Pro Pro Tyr Ala 
    210                 215                 220                 


Gly Gln Val Ser Gly Ser Ser Pro Tyr Arg Pro Pro Met Asn Pro Phe 
225                 230                 235                 240 

Thr Pro Pro Arg Gln Tyr Ser Pro His Ser Pro Pro Arg Gly Ser Pro 
                245                 250                 255     

Tyr Arg Ser Pro Leu Gly Ser Pro Tyr Leu Asn Lys Ser Pro Leu Pro 
            260                 265                 270         

Phe Val His Gly Pro Gly Gln Gln Val Gln Phe Ala Pro Ala Gly Ala 
        275                 280                 285             

Ser Ser His Ser Gly Leu Ile Asp Pro Cys Asn Leu Phe Cys Lys Asn 
    290                 295                 300                 

Leu Asp Pro Asp Ile Asp Ser Asn Ser Leu Phe Thr His Phe Arg Arg 
305                 310                 315                 320 

Val Gly Ile Ile Phe His Ala Leu Tyr Ala Cys Ser Asp Asp Gly Tyr 
                325                 330                 335     

Ile Phe Gln Phe Gly Gln Ile Val Ser Ala Arg Val Met Arg Asn Glu 
            340                 345                 350         

Gln Gly Glu Ser Arg Gly Phe Gly Phe Val Ser Phe Gln Thr Pro Glu 
        355                 360                 365             

Gln Ala Ser Ala Ala Leu His Ala Met Asn Gly Ala Gln Leu Gly Ser 
    370                 375                 380                 

Lys Gln Ile Val Val Arg Leu His Glu Pro Lys Gln Leu Arg Gln Glu 
385                 390                 395                 400 

Lys Leu Ala His Arg Phe Gly His Asn Gly His Pro Arg Ser Ala Ser 
                405                 410                 415     

Gly Ala Thr Ser Pro Thr Ile Ser Glu Ala Gly Asp Tyr His Pro Gly 
            420                 425                 430         

Trp Gly Ser Pro Arg Gly His Pro Ser Gly Leu Ala Ser Pro Ser Ser 
        435                 440                 445             

Lys His Leu Ser Glu Arg Thr Asp Arg Ala Arg Arg Gly Ser Gly Ser 
    450                 455                 460                 

Tyr Tyr Asn Ala Ala Arg Ser Gly Thr Leu Asn Leu Pro Met Lys Tyr 
465                 470                 475                 480 

Asp Glu Leu Ala Ala Leu Thr Pro Val Val Arg Lys Glu Val Leu Thr 
                485                 490                 495     

Gly Glu Leu Asn Arg Arg Ile Thr Glu Met Asn Ile Val Pro Ser Asn 
            500                 505                 510         

Glu Ile Asn Asp Ile Val Glu Gly Ile Ala Asn Leu Thr Leu Ser Val 
        515                 520                 525             

Val Val Gln Thr Leu Glu Asn Pro Asp Lys Leu Arg Glu Gln Val Glu 
    530                 535                 540                 

Leu Arg Ala Lys Asn Leu Thr Val Pro Arg Glu Thr Pro Gly Lys Ser 
545                 550                 555                 560 

Ala Ser Pro Val Ser Thr Ser Gln Glu Ser Ser Thr Ser Asp Leu Asn 
                565                 570                 575     

Ala Ala Asn Ala Thr Ala Ser Ala Pro Glu His Pro Ser Thr Pro Ile 
            580                 585                 590         

Ser Val Ser Ala Thr Leu Ser Thr Pro Pro Arg Thr Ser Ser Pro Ser 
        595                 600                 605             

Gly Ser Val Pro Pro Met Ser Glu Arg Glu Arg Ile Phe Ala Ala Val 
    610                 615                 620                 

Asn Lys Phe Glu Asn Thr Arg Gln Asn Glu Leu Thr Glu Leu Leu Met 
625                 630                 635                 640 

Gly Leu Pro Lys Arg Glu Arg Ala Met Cys Leu Phe Asn Pro Glu Val 
                645                 650                 655     

Leu Arg Val Lys Leu Val Asp Ala Lys Ala Ile Leu Asp Ser Glu Glu 
            660                 665                 670         

Glu Glu Glu Glu Gln Gln Lys Gln Gln Gln Ala Ala Glu Pro Gly Lys 
        675                 680                 685             

Ala Ser Ser Pro Val Arg Ala Ser Glu Gly Thr Asn Thr Ala Val Gln 
    690                 695                 700                 

Ser Pro Val Thr Pro Lys Thr Lys Ala Ile Asn Lys Val Asp Asp Ser 
705                 710                 715                 720 

Pro Thr Thr Pro Asp Leu Ser Ser Arg Gly Pro Ser Ala Thr Ala Ser 
                725                 730                 735     

Pro Leu Pro Gly Thr Pro Gly Gly Pro Ala Ser Ser Thr Thr His Thr 
            740                 745                 750         

Ile Ala Ser Leu Ala Lys Leu Pro Ala Ala Glu Ile Val Arg Leu Ala 
        755                 760                 765             

Asn Leu Ser Ser Thr Thr Gly Leu Pro Leu Pro Lys Ala Asp Pro Leu 
    770                 775                 780                 

Val Val Gln Ala Thr Asp Glu Phe Ile Asp Gly Leu Met Thr Gln Thr 
785                 790                 795                 800 

Leu Leu Val Gln Lys Gln Lys Leu Gly Asp Lys Leu Tyr Lys Val Val 
                805                 810                 815     

Lys Ser Phe Gly Ile Lys Gly Ser Pro Lys Ile Thr Ile Ala Leu Leu 
            820                 825                 830         

Asp Ser Glu Asp Leu Arg Ala Leu 
        835                 840 


<210>  9
<211>  870
<212>  PRT
<213>  Laccaria bicolor

<223>  Rrm4

<400>  9

Met Phe Ser Trp Arg Lys Ser Val Leu Ile Ile Ile Leu Val Ala Thr 
1               5                   10                  15      

Ser Val Ala Ala Ala Pro Ser Pro Lys Asp Thr Arg His Val Arg Asp 
            20                  25                  30          

Gly Ser Leu Asp Asn Pro Ser Phe Ala Asn His Ala Pro Val Trp Asn 
        35                  40                  45              

Glu Gly Ala Ala Ser Glu Pro Leu Ile Ala Ile Glu Gly Glu Thr Pro 
    50                  55                  60                  

Gln Tyr Glu Trp Asp Leu Pro Ala Met Thr Thr Leu Lys Glu Glu Arg 
65                  70                  75                  80  

Phe Gln Glu Leu Met Arg Ile Phe Ile Gly Thr Pro Gln Pro Pro Lys 
                85                  90                  95      

Ser Gly Val Gln Pro Ala Arg Pro Thr Asn Glu Phe Leu Arg Thr Arg 
            100                 105                 110         

Arg Arg Ile Gly Arg Arg Arg His Pro Met Asp Pro Asp Tyr Gln His 
        115                 120                 125             

Pro Gln Asp Ser Asp Phe Gln Gly Pro Gln Pro His Pro Tyr Leu His 
    130                 135                 140                 

Asp Pro Leu Leu His Ile Thr Asn Leu Pro Ser Tyr Val Ser Asp Glu 
145                 150                 155                 160 

Asn Leu Ala Val Ala Phe Met Thr Cys Gly Pro Phe Arg Pro Lys Ile 
                165                 170                 175     

Pro Arg Asp Ser Ala Ser Gly Leu Leu Ser Gly Thr Ile Glu Phe Lys 
            180                 185                 190         

Phe Leu Glu Lys Ala Glu Lys Ala Leu Ala Thr Leu Gln Ser Arg Leu 
        195                 200                 205             

Ile Pro Asn Leu Gln Pro Pro Val Pro Leu Val Leu Ser Pro Tyr Pro 
    210                 215                 220                 

Pro Thr Asn Pro Pro Thr Pro Leu Pro Pro Pro Ser Ala Leu Pro Arg 
225                 230                 235                 240 

Leu Val Lys His Leu Pro Pro Gly Tyr Thr Asp Ser Gln Leu Phe Asp 
                245                 250                 255     

Leu Phe Arg Pro Phe Gly Ala Leu Ala Ser Ala Arg Thr Gln Thr His 
            260                 265                 270         

Phe Gly Ala Asp Thr Gly Met Val Glu Phe Trp Asn Glu Asn Asp Ala 
        275                 280                 285             

Arg Gln Ala Glu Asp Ser Leu His Cys Ala Asp Ile Glu Gly Gln Asn 
    290                 295                 300                 

Ile Ala Val Gln Val Tyr Gln Pro Arg Arg Thr Ser Gly Gly Ala Ile 
305                 310                 315                 320 

Pro Glu Phe Asn Ala Ser Ala Pro Thr Phe Val Pro Ser Gly Ser Met 
                325                 330                 335     

Tyr Ser Pro Tyr Pro Thr Gln Asn Leu Asp Pro Asp Ile Asp Ser Asn 
            340                 345                 350         

Gly Leu Phe Thr His Phe Arg Gln Phe Gly Met Ile Val Ser Ala Arg 
        355                 360                 365             

Val Met Arg Asn Glu Asn Gly Glu Ser Arg Gly Phe Gly Phe Val Ser 
    370                 375                 380                 

Tyr Gln Thr Pro Asp Gln Ala Asn Ala Ala Met His Ala Met Asn Gly 
385                 390                 395                 400 

Ala Gln Leu Gly Ser Lys Gln Val Val Val Arg Leu His Glu Pro Lys 
                405                 410                 415     

Gln Leu Arg Gln Glu Lys Leu Ala Gln Arg Phe Gly His Asn Gly His 
            420                 425                 430         

Pro Arg Ser Ser Ser Gly Ala Thr Ser Pro Thr Ala Ser Glu Val Gly 
        435                 440                 445             

Asp Tyr Ser Gly Trp Gly Ser Pro Arg Leu Leu Pro Thr Ser Leu Gly 
    450                 455                 460                 

Ser Pro Lys Gly Ser Ile Tyr Glu Arg Pro Glu Arg Gly Arg Arg Gly 
465                 470                 475                 480 

Ser Gly Ser Tyr Tyr Asn Ala Ala Leu Thr Gly Thr Leu Asn Leu Pro 
                485                 490                 495     

Met Arg Tyr Asp Asp Leu Ala Ser Leu Ser Pro Val Val Arg Lys Glu 
            500                 505                 510         

Val Leu Thr Gly Glu Leu Ser Arg Arg Val Lys Lys Leu Asp Ile Val 
        515                 520                 525             

Pro Ala Lys Glu Ile Asn Ser Ile Val Glu Ser Leu Val Asn Val Ser 
    530                 535                 540                 

Leu Ser Glu Val Leu Gln Tyr Val Glu Asp Pro Gly Arg Leu Gln Glu 
545                 550                 555                 560 

Gln Val Glu Ile Ile Lys Ala Lys Arg Phe Lys Ala Ser Thr Pro Glu 
                565                 570                 575     

Lys Ser Pro Ser Arg Ser Ala Ser Ala Ser Gln Asp Ser Arg Leu Leu 
            580                 585                 590         

Asp Pro Asn Ala Leu Asn Ala Thr Ala Ser Ala Pro Glu His Pro Ser 
        595                 600                 605             

Thr Pro Ile Ser Val Ser Glu Ser Ser Ser Pro Pro Arg Thr Ser Ser 
    610                 615                 620                 

Pro Ser Gly Ser Val Pro Pro Ile Ser Glu Arg Asp Arg Ile Ile Ala 
625                 630                 635                 640 

Ala Val Gly Lys Leu Glu Ser Thr Arg His Ser Glu Leu Thr Asp Leu 
                645                 650                 655     

Leu Met Ser Leu Pro Lys Arg Asp Arg Ala Leu Cys Leu Phe Asn Ala 
            660                 665                 670         

Glu Tyr Leu Arg Thr Lys Ile Ala Asp Ala Lys Met Val Leu Asp Ser 
        675                 680                 685             

Glu Asp Gly Asp Glu Glu Glu Asp Arg Asn Pro Pro Asp Ser Gln Ser 
    690                 695                 700                 

Thr Lys Ser Ala Pro His Thr Val Pro Val Thr Pro Gln Pro Lys Lys 
705                 710                 715                 720 

Thr Ala Pro Arg Val Val Asp Ser Pro Gln Thr Pro Asp Leu Ser Ser 
                725                 730                 735     

Arg Gly Pro Ser Ala Asn Ala Ser Pro Leu Pro Pro Thr Pro Gly Ser 
            740                 745                 750         

Ala Ser Ser Thr His Thr Leu Ala Ser Leu Ser Lys Leu Pro Ala Ala 
        755                 760                 765             

Glu Ile Ile Arg Leu Ser Asn Ser Ser Ser Ala Thr Gly Leu Pro Leu 
    770                 775                 780                 

Pro Lys Ala Asp Pro Leu Val Val Gln Ala Thr Asp Glu Phe Ile Asp 
785                 790                 795                 800 

Ser Leu Leu Gly Lys Pro Pro Gln Val Gln Lys Gln Gln Leu Gly Asp 
                805                 810                 815     

Lys Leu Phe Lys Val Val Lys Ser Phe Gly Ile Lys Gly Ala Pro Lys 
            820                 825                 830         

Val Thr Ile Ala Leu Leu Asp Gln Glu Asp Leu Arg Ala Leu Ala His 
        835                 840                 845             

Leu Met Asn Ser Phe Pro Ser Val Leu Lys Asp Lys Ala Leu Arg Val 
    850                 855                 860                 

Ala Ala Ser Leu Ala Lys 
865                 870 


<210>  10
<211>  779
<212>  PRT
<213>  Schizophyllum commune

<223>  Rrm4

<400>  10

Met Ala Lys Pro Glu Gly His Pro His Pro Tyr Leu His Asp Pro Leu 
1               5                   10                  15      

Leu Tyr Ile Thr Asn Ile Pro Lys Ser Val Thr Asp Asp Val Leu Ala 
            20                  25                  30          

Thr Ala Phe Val Ser Cys Ala Pro Phe Arg Pro Arg Ile Asn Arg Asp 
        35                  40                  45              

Thr Asp Ala Pro Met Leu Ser Gly Thr Ile Glu Phe Lys Tyr Leu Glu 
    50                  55                  60                  

Lys Ala Glu Cys Ala Leu Ala Thr Leu Gln Gly Arg Tyr Ile Pro Leu 
65                  70                  75                  80  

Thr Ala Pro Pro Val Pro Leu Val Leu Ser Pro Tyr Pro Pro Thr Asp 
                85                  90                  95      

Pro Pro Thr Pro Val Pro Pro Pro Ser Ala His Pro Arg Leu Ile Lys 
            100                 105                 110         

His Leu Pro Pro Gly Tyr Thr Asp Gln Gln Leu Tyr Glu Leu Cys Arg 
        115                 120                 125             

Pro Phe Gly Ala Leu Ala Ser Ala Arg Ala Gln Thr His Phe Gly Ala 
    130                 135                 140                 

Asp Thr Gly Met Val Glu Phe Trp Asn Glu Asp Asp Gly Arg Thr Ala 
145                 150                 155                 160 

Glu Glu Ser Leu His Cys Glu Glu Val Glu Gly Gln Ser Ile Ala Val 
                165                 170                 175     

Val Met Tyr Gln Pro Arg Arg Ala Ser Gly Gly Met Ala Glu Phe Ala 
            180                 185                 190         

Asn Ala Pro Ser Phe Val Pro Ala Gly Ser Gly Phe Gly Tyr Gln Thr 
        195                 200                 205             

Pro Gln Ser Pro Pro Arg Gln Ala Phe Arg Arg Thr Pro Pro Ser Pro 
    210                 215                 220                 

Phe Ile His Gly Pro Gly Gln Gln Val Gln Val Ala Pro Val Thr Gly 
225                 230                 235                 240 

Pro Gly Ser Asn Ser His Ser Gly Leu Ile Asp Pro Cys Asn Leu Phe 
                245                 250                 255     

Cys Lys Asn Leu Asp Pro Glu Ile Asp Ser Asn Ser Leu Phe Ser His 
            260                 265                 270         

Phe Arg Ala Tyr Gly Ser Ile Val Ser Ala Arg Val Met Arg Asn Glu 
        275                 280                 285             

Asn Gly Glu Ser Arg Gly Phe Gly Phe Val Ser Phe Gln Thr Pro Asp 
    290                 295                 300                 

Gln Ala Ala Ala Ala Met His Ala Met Asn Gly Arg Gln Ile Gly Ser 
305                 310                 315                 320 

Lys Ala Ile Val Val Arg Leu His Glu Pro Lys Gln Leu Arg Gln Glu 
                325                 330                 335     

Lys Leu Ala Ala Arg Phe Gly Gly His Asn Gly His Pro Arg Ser Val 
            340                 345                 350         

Ser Gly Ala Thr Ser Pro Thr Pro Ser Glu Gly Gly Ser Tyr Val Gly 
        355                 360                 365             

Trp Ser Ser Pro Pro Thr Ala Thr Ser Pro Leu Gly Gly Ser Pro His 
    370                 375                 380                 

Pro Thr Pro Ser Val Ala Gly Phe Gly Asp Lys Thr Asp Arg Gly Arg 
385                 390                 395                 400 

Arg Gly Ser Gly Ser Tyr Tyr Asn Leu Thr Arg Leu Thr Lys Met Val 
                405                 410                 415     

Lys Ala Ala Leu Ser Gly Gln Leu Asn Leu Pro Met Lys Tyr Glu Glu 
            420                 425                 430         

Leu Ser Asn Leu Ser Pro Val Val Arg Tyr Glu Val Leu Thr Gly Glu 
        435                 440                 445             

Leu Ser Arg Arg Val Lys Thr Met Asp Val Val Pro Leu Asp Asp Val 
    450                 455                 460                 

Glu Arg Ile Val Glu Gly Ile Val Asn Leu Lys Leu Asp Glu Val Val 
465                 470                 475                 480 

Lys Leu Leu Asp Asp Pro Gly Lys Leu Ser Gln Thr Val Met Ser Met 
                485                 490                 495     

Arg Pro Ser Lys Ser Pro Ser Pro Ser Ala Ser Gln Asp Ser Arg Leu 
            500                 505                 510         

Leu Asp Ala Gln Thr Leu Asn Ala Thr Ala Ser Ala Pro Glu His Pro 
        515                 520                 525             

Ser Thr Pro Ile Ser Ala Asn Ala Ser Leu Ser Thr Pro Pro Arg Thr 
    530                 535                 540                 

Ser Ser Pro Ser Gly Ser Ala Pro His Gln Thr Glu Arg Glu Arg Val 
545                 550                 555                 560 

Phe Ala Ala Val Cys Arg Leu Glu Ser Thr Asn Gln Glu Ala Leu Thr 
                565                 570                 575     

Asp Leu Leu Met Ser Leu Pro Lys Arg Glu Arg Ala Leu Leu Leu Phe 
            580                 585                 590         

Asn Ala Glu Thr Leu Arg Ala Lys Leu Val Asp Ala Lys Ala Val Leu 
        595                 600                 605             

Glu Ala Ser Asp Asp Asp Glu Pro Pro Ala Pro Thr Val Pro Val Thr 
    610                 615                 620                 

Pro Gln Pro Lys Arg Lys Ala Gln Leu Ala Ser Ala Ser Pro Gln Thr 
625                 630                 635                 640 

Pro Glu Leu Ser Ser Arg Gly Pro Ser Ala Thr Ser Ser Pro Ala Pro 
                645                 650                 655     

Ala Thr Pro Ser Ala His Thr Thr Val Ser Gly Glu Phe Ser Ser Ala 
            660                 665                 670         

Lys Leu Ala Arg Met Leu Ala Gln Asp Ile Ile Lys Ile Ala Asn Thr 
        675                 680                 685             

Thr Pro Asp Phe Pro Tyr Pro Lys Pro Asp Leu Ala Ala Val His Asp 
    690                 695                 700                 

Thr Asn Ala Tyr Val Asp Ser Met Met Asp Leu Pro Leu Ala Asn Arg 
705                 710                 715                 720 

Lys Gln Arg Val Gly Ser Glu Ile Thr Lys Ile Ala Lys Pro Tyr Leu 
                725                 730                 735     

Lys Lys Pro Thr Lys Val Ala Met Val Met Val Asp Gly Glu Asp Asp 
            740                 745                 750         

Leu Arg Ser Leu Val Leu Leu Met Arg His Tyr Pro Glu Ile Phe Lys 
        755                 760                 765             

Glu Lys Ala Thr Leu Ala Ser Ala Arg Met Val 
    770                 775                 

