                         SEQUENCE LISTING

<110>  AMGEN INC.
       Arnett, Heather A.
       Escobar, Sabine S.
       Swanson, Ryan M.
       Viney, Joanne L.
 
<120>  BTNL9 PROTEINS, NUCLEIC ACIDS, AND ANTIBODIES AND USES THEREOF

<130>  A-1568-WO-PCT

<140>  --to be assigend--
<141>  2011-04-08

<150>  61/322,800
<151>  2010-04-09

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  3520
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (232)..(1836)

<400>  1
agagcaaacg gcatatatct tagggtggaa gatggataaa taattctgtc acacgtgccc       60

tggcctctgg agctcagctg ccagtccacg tctagggaat cttagcatct gggaccaaga      120

cactttacag caatcatcac cctttgcaga ggaggtgagc tcaccaggac tcatctgcca      180

tttcagacct tttgctgcta cctgccaggt ggcccccact gctgacgaga g atg gtg       237
                                                         Met Val          
                                                         1                

gac ctc tca gtc tcc cca gac tcc ttg aag cca gta tcg ctg acc agc        285
Asp Leu Ser Val Ser Pro Asp Ser Leu Lys Pro Val Ser Leu Thr Ser           
        5                   10                  15                        

agt ctt gtc ttc ctc atg cac ctc ctc ctc ctt cag cct ggg gag ccg        333
Ser Leu Val Phe Leu Met His Leu Leu Leu Leu Gln Pro Gly Glu Pro           
    20                  25                  30                            

agc tca gag gtc aag gtg cta ggc cct gag tat ccc atc ctg gcc ctc        381
Ser Ser Glu Val Lys Val Leu Gly Pro Glu Tyr Pro Ile Leu Ala Leu           
35                  40                  45                  50            

gtc ggg gag gag gtg gag ttc ccg tgc cac cta tgg cca cag ctg gat        429
Val Gly Glu Glu Val Glu Phe Pro Cys His Leu Trp Pro Gln Leu Asp           
                55                  60                  65                

gcc cag caa atg gag atc cgc tgg ttc cgg agt cag acc ttc aat gtg        477
Ala Gln Gln Met Glu Ile Arg Trp Phe Arg Ser Gln Thr Phe Asn Val           
            70                  75                  80                    

gta cac ctg tac cag gag cag cag gag ctc cct ggc agg cag atg ccg        525
Val His Leu Tyr Gln Glu Gln Gln Glu Leu Pro Gly Arg Gln Met Pro           
        85                  90                  95                        

gcg ttc cgg aac agg acc aag ttg gtc aag gac gac atc gcc tat ggc        573
Ala Phe Arg Asn Arg Thr Lys Leu Val Lys Asp Asp Ile Ala Tyr Gly           
    100                 105                 110                           

agc gtg gtc ctg cag ctt cac agc atc atc ccc tct gac aag ggc aca        621
Ser Val Val Leu Gln Leu His Ser Ile Ile Pro Ser Asp Lys Gly Thr           
115                 120                 125                 130           

tat ggc tgc cgc ttc cac tcc gac aac ttc tct ggc gaa gct ctc tgg        669
Tyr Gly Cys Arg Phe His Ser Asp Asn Phe Ser Gly Glu Ala Leu Trp           
                135                 140                 145               

gaa ctg gag gta gca ggg ctg ggc tca gac cct cac ctc tcc ctt gag        717
Glu Leu Glu Val Ala Gly Leu Gly Ser Asp Pro His Leu Ser Leu Glu           
            150                 155                 160                   

ggc ttc aag gaa gga ggc att cag ctg agg ctc aga tcc agt ggc tgg        765
Gly Phe Lys Glu Gly Gly Ile Gln Leu Arg Leu Arg Ser Ser Gly Trp           
        165                 170                 175                       

tac ccc aag cct aag gtt cag tgg aga gac cac cag gga cag tgc ctg        813
Tyr Pro Lys Pro Lys Val Gln Trp Arg Asp His Gln Gly Gln Cys Leu           
    180                 185                 190                           

cct cca gag ttt gaa gcc atc gtc tgg gat gcc cag gac ctg ttc agt        861
Pro Pro Glu Phe Glu Ala Ile Val Trp Asp Ala Gln Asp Leu Phe Ser           
195                 200                 205                 210           

ctg gaa aca tct gtg gtt gtc cga gcg gga gcc ctc agc aat gtg tcc        909
Leu Glu Thr Ser Val Val Val Arg Ala Gly Ala Leu Ser Asn Val Ser           
                215                 220                 225               

gtc tcc atc cag aat ctc ctc ttg agc cag aag aaa gag ttg gtg gtc        957
Val Ser Ile Gln Asn Leu Leu Leu Ser Gln Lys Lys Glu Leu Val Val           
            230                 235                 240                   

cag ata gca gac gtg ttc gta ccc gga gcc tct gcg tgg aag agc gcg       1005
Gln Ile Ala Asp Val Phe Val Pro Gly Ala Ser Ala Trp Lys Ser Ala           
        245                 250                 255                       

ttc gtc gcg acc ctg ccg ctg ctg ttg gtc ctc gcg gcg ctg gcg ctg       1053
Phe Val Ala Thr Leu Pro Leu Leu Leu Val Leu Ala Ala Leu Ala Leu           
    260                 265                 270                           

ggc gtc ctc cgg aag cag cgg aga agc cga gaa aag ctg agg aag cag       1101
Gly Val Leu Arg Lys Gln Arg Arg Ser Arg Glu Lys Leu Arg Lys Gln           
275                 280                 285                 290           

gcg gag aag aga caa gag aaa ctc act gca gag ctg gaa aag ctt cag       1149
Ala Glu Lys Arg Gln Glu Lys Leu Thr Ala Glu Leu Glu Lys Leu Gln           
                295                 300                 305               

aca gag ctt gac tgg aga cgg gct gaa ggc cag gct gag tgg aga gca       1197
Thr Glu Leu Asp Trp Arg Arg Ala Glu Gly Gln Ala Glu Trp Arg Ala           
            310                 315                 320                   

gcc caa aaa tat gca gtg gat gtg acg ctg gac ccg gcc tcg gcg cac       1245
Ala Gln Lys Tyr Ala Val Asp Val Thr Leu Asp Pro Ala Ser Ala His           
        325                 330                 335                       

ccc agc ctg gag gtg tcg gag gat ggc aag agc gtg tct tcc cgc ggg       1293
Pro Ser Leu Glu Val Ser Glu Asp Gly Lys Ser Val Ser Ser Arg Gly           
    340                 345                 350                           

gcg ccg cca ggc ccg gcg cct ggc cac ccg cag cgg ttc tcg gag cag       1341
Ala Pro Pro Gly Pro Ala Pro Gly His Pro Gln Arg Phe Ser Glu Gln           
355                 360                 365                 370           

acg tgc gcg ctg agc ctg gag cgg ttc tcc gcc ggc cgc cac tac tgg       1389
Thr Cys Ala Leu Ser Leu Glu Arg Phe Ser Ala Gly Arg His Tyr Trp           
                375                 380                 385               

gag gtg cac gtg ggc cgc cgc agc cgc tgg ttc ctg ggc gcc tgc ctg       1437
Glu Val His Val Gly Arg Arg Ser Arg Trp Phe Leu Gly Ala Cys Leu           
            390                 395                 400                   

gcc gcg gtg ccg cgc gcg ggg cct gcg cgc ctg agc cct gcg gcc ggc       1485
Ala Ala Val Pro Arg Ala Gly Pro Ala Arg Leu Ser Pro Ala Ala Gly           
        405                 410                 415                       

tac tgg gtg ctg ggg ctg tgg aac ggc tgc gag tac ttc gtc ctg gcc       1533
Tyr Trp Val Leu Gly Leu Trp Asn Gly Cys Glu Tyr Phe Val Leu Ala           
    420                 425                 430                           

ccg cac cgc gtc gcg ctc acc ctg cgc gtg ccc ccg cgg cgc ctg ggc       1581
Pro His Arg Val Ala Leu Thr Leu Arg Val Pro Pro Arg Arg Leu Gly           
435                 440                 445                 450           

gtc ttc ctg gac tac gag gcc gga gag ctg tcc ttc ttc aac gtg tcc       1629
Val Phe Leu Asp Tyr Glu Ala Gly Glu Leu Ser Phe Phe Asn Val Ser           
                455                 460                 465               

gac ggc tcc cac atc ttc acc ttc cac gac acc ttc tcg ggc gcg ctc       1677
Asp Gly Ser His Ile Phe Thr Phe His Asp Thr Phe Ser Gly Ala Leu           
            470                 475                 480                   

tgt gcg tac ttc agg ccc agg gcc cac gac ggc ggc gaa cat ccg gat       1725
Cys Ala Tyr Phe Arg Pro Arg Ala His Asp Gly Gly Glu His Pro Asp           
        485                 490                 495                       

ccc ctg acc atc tgc ccg ctg ccg gtt aga ggg acg ggc gtc ccc gaa       1773
Pro Leu Thr Ile Cys Pro Leu Pro Val Arg Gly Thr Gly Val Pro Glu           
    500                 505                 510                           

gag aac gac agt gac acc tgg cta cag ccc tat gag ccc gcg gac ccc       1821
Glu Asn Asp Ser Asp Thr Trp Leu Gln Pro Tyr Glu Pro Ala Asp Pro           
515                 520                 525                 530           

gcc ctg gac tgg tgg tgaggcgccc tcgtggccgc gggactggcc ccggggggcc       1876
Ala Leu Asp Trp Trp                                                       
                535                                                       

ccctggatcc caggccagcg ctttgctctc ctgctccgtc tgaagggagc aggtgcacca     1936

gccaaaatgt cagcgagggg gacaaagaga gggacctttg cctacgtaga tgtgtatgtg     1996

tagtgcgatt ttcttcaagg aaaggagaca agtccaaagc tcgtttgtgg attgtgggac     2056

tgagcgaagg agtacaaata tatccacgtc gctcagagct ggggtgctca cggtgggcgg     2116

tgggcaagaa gccagcatgg aagaaagaag ggagaaaact ttggtgactg ccttagaggg     2176

atcagttaat ttgtatagtt ttatattttt tgtatatgtt tgctagctct aaaaaggtcg     2236

agatgcaata acacttcgta agcaacgagt tcacctaagt aaggctcaga tcctagtttt     2296

aaaaaccatt tcccattaaa atgaagttgg aggaacagct gcttctggag ccggggcaaa     2356

aatttcaagg tgagcctgga gcattgtgtg tggtgaagta aaataaaggc tcaaaacgtg     2416

acggcaaccc ggcaaaaggg tagggagcca ggccgaaggg gcctcactga ccaattgtgg     2476

gacaatttga acatcaggat gaataatgac aggagagatt ataacacact gaataaaaac     2536

ataatccatg agttcatgct gatactcaaa tttcttttta aaaaggagaa acaggaaggt     2596

ttcttttgga ggtgaaatct aattattggt gagagtcttg gagaacaggc tgtttccagt     2656

ctcaaagcag taaccttata cactacttat aagtttgaaa ggggaaaggt tacctttaca     2716

atggagacat ctaccagatc atccaagtga ttaaatttaa catcatcaat gatgggacca     2776

aggacattat tagtttgaca actggggaaa gaagtgttct tcacccccta cccccaagac     2836

attgtctctg tcggccaggc tggagtgcag cctcaacctc ctgggtccaa gtgatcctcc     2896

cacctcagca cacaacacca tgcccaattt taagtgcgtt atagagacgg gggtctcact     2956

ttgttaccca ggctggtctc aaactcctgc gctcaagcaa tcctcccacc tgggcctccc     3016

aaaatgctgg gtgtacaggc atgagccgct gtgcctggct tcattttcag agtgagacat     3076

ttgtactgtg gctatgtagg agaacattct tgttcttagc aaacatactg aagtttttag     3136

atattaatta ccacagtgtc tgccactgaa tttccagtga ctaagtggaa aaatataaaa     3196

catatgaata taaagaaaga aagagacaag tcaaatgtag taaaatgaca acacttggtg     3256

actctaggtg actggtcgac agatgttcat tgtactatca atgtggcttt gctgtgggtt     3316

tgaaattttg caaactaaga gttgggtggc ggggagaagg atacaccaaa aaactaagtg     3376

attatctttg gatgggaaaa tgtttggtaa ttgcattctt aaaatgtctt ctttgtattt     3436

tttaatgttc aataatgtat atgtatcagt tctgtaataa aggggaaaac acttttttta     3496

aataaaaaaa aaaaaaaaaa aaaa                                            3520


<210>  2
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Asp Leu Ser Val Ser Pro Asp Ser Leu Lys Pro Val Ser Leu 
1               5                   10                  15      


Thr Ser Ser Leu Val Phe Leu Met His Leu Leu Leu Leu Gln Pro Gly 
            20                  25                  30          


Glu Pro Ser Ser Glu Val Lys Val Leu Gly Pro Glu Tyr Pro Ile Leu 
        35                  40                  45              


Ala Leu Val Gly Glu Glu Val Glu Phe Pro Cys His Leu Trp Pro Gln 
    50                  55                  60                  


Leu Asp Ala Gln Gln Met Glu Ile Arg Trp Phe Arg Ser Gln Thr Phe 
65                  70                  75                  80  


Asn Val Val His Leu Tyr Gln Glu Gln Gln Glu Leu Pro Gly Arg Gln 
                85                  90                  95      


Met Pro Ala Phe Arg Asn Arg Thr Lys Leu Val Lys Asp Asp Ile Ala 
            100                 105                 110         


Tyr Gly Ser Val Val Leu Gln Leu His Ser Ile Ile Pro Ser Asp Lys 
        115                 120                 125             


Gly Thr Tyr Gly Cys Arg Phe His Ser Asp Asn Phe Ser Gly Glu Ala 
    130                 135                 140                 


Leu Trp Glu Leu Glu Val Ala Gly Leu Gly Ser Asp Pro His Leu Ser 
145                 150                 155                 160 


Leu Glu Gly Phe Lys Glu Gly Gly Ile Gln Leu Arg Leu Arg Ser Ser 
                165                 170                 175     


Gly Trp Tyr Pro Lys Pro Lys Val Gln Trp Arg Asp His Gln Gly Gln 
            180                 185                 190         


Cys Leu Pro Pro Glu Phe Glu Ala Ile Val Trp Asp Ala Gln Asp Leu 
        195                 200                 205             


Phe Ser Leu Glu Thr Ser Val Val Val Arg Ala Gly Ala Leu Ser Asn 
    210                 215                 220                 


Val Ser Val Ser Ile Gln Asn Leu Leu Leu Ser Gln Lys Lys Glu Leu 
225                 230                 235                 240 


Val Val Gln Ile Ala Asp Val Phe Val Pro Gly Ala Ser Ala Trp Lys 
                245                 250                 255     


Ser Ala Phe Val Ala Thr Leu Pro Leu Leu Leu Val Leu Ala Ala Leu 
            260                 265                 270         


Ala Leu Gly Val Leu Arg Lys Gln Arg Arg Ser Arg Glu Lys Leu Arg 
        275                 280                 285             


Lys Gln Ala Glu Lys Arg Gln Glu Lys Leu Thr Ala Glu Leu Glu Lys 
    290                 295                 300                 


Leu Gln Thr Glu Leu Asp Trp Arg Arg Ala Glu Gly Gln Ala Glu Trp 
305                 310                 315                 320 


Arg Ala Ala Gln Lys Tyr Ala Val Asp Val Thr Leu Asp Pro Ala Ser 
                325                 330                 335     


Ala His Pro Ser Leu Glu Val Ser Glu Asp Gly Lys Ser Val Ser Ser 
            340                 345                 350         


Arg Gly Ala Pro Pro Gly Pro Ala Pro Gly His Pro Gln Arg Phe Ser 
        355                 360                 365             


Glu Gln Thr Cys Ala Leu Ser Leu Glu Arg Phe Ser Ala Gly Arg His 
    370                 375                 380                 


Tyr Trp Glu Val His Val Gly Arg Arg Ser Arg Trp Phe Leu Gly Ala 
385                 390                 395                 400 


Cys Leu Ala Ala Val Pro Arg Ala Gly Pro Ala Arg Leu Ser Pro Ala 
                405                 410                 415     


Ala Gly Tyr Trp Val Leu Gly Leu Trp Asn Gly Cys Glu Tyr Phe Val 
            420                 425                 430         


Leu Ala Pro His Arg Val Ala Leu Thr Leu Arg Val Pro Pro Arg Arg 
        435                 440                 445             


Leu Gly Val Phe Leu Asp Tyr Glu Ala Gly Glu Leu Ser Phe Phe Asn 
    450                 455                 460                 


Val Ser Asp Gly Ser His Ile Phe Thr Phe His Asp Thr Phe Ser Gly 
465                 470                 475                 480 


Ala Leu Cys Ala Tyr Phe Arg Pro Arg Ala His Asp Gly Gly Glu His 
                485                 490                 495     


Pro Asp Pro Leu Thr Ile Cys Pro Leu Pro Val Arg Gly Thr Gly Val 
            500                 505                 510         


Pro Glu Glu Asn Asp Ser Asp Thr Trp Leu Gln Pro Tyr Glu Pro Ala 
        515                 520                 525             


Asp Pro Ala Leu Asp Trp Trp 
    530                 535 


<210>  3
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  4
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala 
            20                  25      


<210>  5
<211>  2463
<212>  DNA
<213>  Mus sp


<220>
<221>  CDS
<222>  (124)..(1731)

<400>  5
agcttagcat cagggactaa catttcacaa tcaccccctt tagagggagg tgagattgcc       60

agcatccctc taccgcttgg atcttcttct gttacctgaa aggtgggccc tcaccgctga      120

cag atg gca gat ttc tca gta ttt ctg ggg ttt ctg aag caa ata cct        168
    Met Ala Asp Phe Ser Val Phe Leu Gly Phe Leu Lys Gln Ile Pro           
    1               5                   10                  15            

cgg tgc ctc agc atc ttc ttc acc tac ctt ctc ttc ctt cag ttg tgg        216
Arg Cys Leu Ser Ile Phe Phe Thr Tyr Leu Leu Phe Leu Gln Leu Trp           
                20                  25                  30                

gag gtg aac tca gac aag gtc tgg gtg ttg ggc cct gag gag tcc att        264
Glu Val Asn Ser Asp Lys Val Trp Val Leu Gly Pro Glu Glu Ser Ile           
            35                  40                  45                    

ttg gcc cgc gtc ggg gaa gcg gtg gag ttc cca tgt cgc tta tca tca        312
Leu Ala Arg Val Gly Glu Ala Val Glu Phe Pro Cys Arg Leu Ser Ser           
        50                  55                  60                        

tac caa gac gca gag cac atg gaa att cgc tgg ttt cgg gcc cag gtc        360
Tyr Gln Asp Ala Glu His Met Glu Ile Arg Trp Phe Arg Ala Gln Val           
    65                  70                  75                            

tcc aac gtg gtg tac ctg tac cag gag ccg cag ggg cgc tcc agc ctg        408
Ser Asn Val Val Tyr Leu Tyr Gln Glu Pro Gln Gly Arg Ser Ser Leu           
80                  85                  90                  95            

cag atg gca cag ttc cga aac agg acc tta ttt gaa gcc tat gac att        456
Gln Met Ala Gln Phe Arg Asn Arg Thr Leu Phe Glu Ala Tyr Asp Ile           
                100                 105                 110               

gca gag gga agc gtg aac cta cac atc ctt aaa gtg ctt ccc tcc gac        504
Ala Glu Gly Ser Val Asn Leu His Ile Leu Lys Val Leu Pro Ser Asp           
            115                 120                 125                   

gag ggc cga tat ggg tgc cgc ttt ctt tct gac aac ttc tct ggt gaa        552
Glu Gly Arg Tyr Gly Cys Arg Phe Leu Ser Asp Asn Phe Ser Gly Glu           
        130                 135                 140                       

gcc acg tgg gag ctg gaa gta gca gga tcg ggc tca gac cca cac atc        600
Ala Thr Trp Glu Leu Glu Val Ala Gly Ser Gly Ser Asp Pro His Ile           
    145                 150                 155                           

tcc ctc cag ggc ttc agt gga gaa ggt att cag ctg cag tgc agt tcc        648
Ser Leu Gln Gly Phe Ser Gly Glu Gly Ile Gln Leu Gln Cys Ser Ser           
160                 165                 170                 175           

agt ggc tgg tac ccc aag cca aag gtt cag tgg aga ggt cac cag ggt        696
Ser Gly Trp Tyr Pro Lys Pro Lys Val Gln Trp Arg Gly His Gln Gly           
                180                 185                 190               

cag tgc ctt tct cca gag tct gaa gcc atc acc cag aat gcc caa ggc        744
Gln Cys Leu Ser Pro Glu Ser Glu Ala Ile Thr Gln Asn Ala Gln Gly           
            195                 200                 205                   

ctg ttc agt ctg gag aca tcc gtg att gtc cga gga gga gcc cat agc        792
Leu Phe Ser Leu Glu Thr Ser Val Ile Val Arg Gly Gly Ala His Ser           
        210                 215                 220                       

aat gtg tct tgt ata atc cag aac ccc ttg ctg ccc cag aag aaa gaa        840
Asn Val Ser Cys Ile Ile Gln Asn Pro Leu Leu Pro Gln Lys Lys Glu           
    225                 230                 235                           

ttc gtg atc cag att gca gat gtg ttc cta ccc aga atg tcc ccc tgg        888
Phe Val Ile Gln Ile Ala Asp Val Phe Leu Pro Arg Met Ser Pro Trp           
240                 245                 250                 255           

aag aaa gcg ttt gtg gga acc ctg gtg gtc ctg ccg ctc agt ctg att        936
Lys Lys Ala Phe Val Gly Thr Leu Val Val Leu Pro Leu Ser Leu Ile           
                260                 265                 270               

gtg ctc acc atg ctg gcg ctg cga tat ttt tac aag ctg cgg agc ttc        984
Val Leu Thr Met Leu Ala Leu Arg Tyr Phe Tyr Lys Leu Arg Ser Phe           
            275                 280                 285                   

caa gaa aaa cag gtg aag cag gga gag gag gtc cga gag aaa ctt cag       1032
Gln Glu Lys Gln Val Lys Gln Gly Glu Glu Val Arg Glu Lys Leu Gln           
        290                 295                 300                       

aca gag ctt gac tgg aga agg tct gaa ggc cag gct gag tgg aga gca       1080
Thr Glu Leu Asp Trp Arg Arg Ser Glu Gly Gln Ala Glu Trp Arg Ala           
    305                 310                 315                           

gcc cag caa tat gca gcg gat gtg acc ttg gat cct gcc aca gcg cac       1128
Ala Gln Gln Tyr Ala Ala Asp Val Thr Leu Asp Pro Ala Thr Ala His           
320                 325                 330                 335           

cct agc ctg gag gtc tcc aac aac ggc aag acc gtg tcc tcc cgc ctg       1176
Pro Ser Leu Glu Val Ser Asn Asn Gly Lys Thr Val Ser Ser Arg Leu           
                340                 345                 350               

ggg gtg ccc agt att gca gct ggg gac ccg cag cgg ttc tcg gag cag       1224
Gly Val Pro Ser Ile Ala Ala Gly Asp Pro Gln Arg Phe Ser Glu Gln           
            355                 360                 365                   

acc tgc gtg ctg agc cgg gag cgc ttc tcc agc ggc cgc cac tac tgg       1272
Thr Cys Val Leu Ser Arg Glu Arg Phe Ser Ser Gly Arg His Tyr Trp           
        370                 375                 380                       

gag gtg cac gtg ggc cgg cgc agc cgc tgg ttc ctg ggc gcc tgt ctg       1320
Glu Val His Val Gly Arg Arg Ser Arg Trp Phe Leu Gly Ala Cys Leu           
    385                 390                 395                           

gag tcg gtg gag cgc tcc ggg ccc gcg cgc ctg agc ccg gcg gct ggc       1368
Glu Ser Val Glu Arg Ser Gly Pro Ala Arg Leu Ser Pro Ala Ala Gly           
400                 405                 410                 415           

tac tgg gtg atg ggg ctg tgg aac cgc tgc gag tac ttc gtg ctg gac       1416
Tyr Trp Val Met Gly Leu Trp Asn Arg Cys Glu Tyr Phe Val Leu Asp           
                420                 425                 430               

ccg cat cgc gtg gca ctg gcg cta cgc gtg cct ccc cgg agg ata ggc       1464
Pro His Arg Val Ala Leu Ala Leu Arg Val Pro Pro Arg Arg Ile Gly           
            435                 440                 445                   

gtc ctg ttg gac tac gag gcc ggg aag ctg tct ttc ttc aac gtg tct       1512
Val Leu Leu Asp Tyr Glu Ala Gly Lys Leu Ser Phe Phe Asn Val Ser           
        450                 455                 460                       

gat ggc tcg cac atc ttc agc ttc acc gac act ttc tca ggg gcg ctc       1560
Asp Gly Ser His Ile Phe Ser Phe Thr Asp Thr Phe Ser Gly Ala Leu           
    465                 470                 475                           

cgc gcc tac tta agg ccc cga gct cac gac ggc agt gaa cat ccg gat       1608
Arg Ala Tyr Leu Arg Pro Arg Ala His Asp Gly Ser Glu His Pro Asp           
480                 485                 490                 495           

cct atg acc atc tgc tct ttg ccg gtt aga ggg cca cag gtc ctc gaa       1656
Pro Met Thr Ile Cys Ser Leu Pro Val Arg Gly Pro Gln Val Leu Glu           
                500                 505                 510               

gag aac gac aac gac aac tgg cta cag ccc tat gag cct ctg gac ccc       1704
Glu Asn Asp Asn Asp Asn Trp Leu Gln Pro Tyr Glu Pro Leu Asp Pro           
            515                 520                 525                   

gcc tgg gct gtt aat gag gca gtg tcc tgacctcaag gccaggtcca             1751
Ala Trp Ala Val Asn Glu Ala Val Ser                                       
        530                 535                                           

agcactgtcc tgaactcctg gacagcgctt tgctctcctg cagccaaagc agagtcagca     1811

gaaagaggac agagagagag ggcctataca gatgaatgta tataattatc tttaaacaga     1871

caaatgaaag attgtttgtg tatatagcag gattctggag tgtgcagtgt agaagatggg     1931

aaagaatcat aattatccgc taatgtgtgt atagttctgt atagtgtata tgtgtgtgtg     1991

tgtgtgtgtg tgtgtgtgtg tgtaattttg tggatcctgc aaaagtctag aagtaatgtc     2051

atttcataag caatgagttc acctttggct cagaatacag tttatagcga cttccttgat     2111

catgtatgtg gcaattcgaa catgaaattc aataatggca gtgatgtggc tggctggggg     2171

taagcagtgg tagagtgctt gcctagcccg agggatagca cacatcttca acttcactgc     2231

cgatttcccc agaaaagtgc attggatccc ccgctcaggt ggagcaggat aaggatggca     2291

ggaatgcagc gatactccta aaacataaac atacatataa gtaacattta caaacagaaa     2351

aggctatatt tagcaaaata taagtatata catatactca tctaatatca ttaattttaa     2411

aagccatgat tttgaaagag agctagaagt gaggcatagg agaatttgag gg             2463


<210>  6
<211>  536
<212>  PRT
<213>  Mus sp

<400>  6

Met Ala Asp Phe Ser Val Phe Leu Gly Phe Leu Lys Gln Ile Pro Arg 
1               5                   10                  15      


Cys Leu Ser Ile Phe Phe Thr Tyr Leu Leu Phe Leu Gln Leu Trp Glu 
            20                  25                  30          


Val Asn Ser Asp Lys Val Trp Val Leu Gly Pro Glu Glu Ser Ile Leu 
        35                  40                  45              


Ala Arg Val Gly Glu Ala Val Glu Phe Pro Cys Arg Leu Ser Ser Tyr 
    50                  55                  60                  


Gln Asp Ala Glu His Met Glu Ile Arg Trp Phe Arg Ala Gln Val Ser 
65                  70                  75                  80  


Asn Val Val Tyr Leu Tyr Gln Glu Pro Gln Gly Arg Ser Ser Leu Gln 
                85                  90                  95      


Met Ala Gln Phe Arg Asn Arg Thr Leu Phe Glu Ala Tyr Asp Ile Ala 
            100                 105                 110         


Glu Gly Ser Val Asn Leu His Ile Leu Lys Val Leu Pro Ser Asp Glu 
        115                 120                 125             


Gly Arg Tyr Gly Cys Arg Phe Leu Ser Asp Asn Phe Ser Gly Glu Ala 
    130                 135                 140                 


Thr Trp Glu Leu Glu Val Ala Gly Ser Gly Ser Asp Pro His Ile Ser 
145                 150                 155                 160 


Leu Gln Gly Phe Ser Gly Glu Gly Ile Gln Leu Gln Cys Ser Ser Ser 
                165                 170                 175     


Gly Trp Tyr Pro Lys Pro Lys Val Gln Trp Arg Gly His Gln Gly Gln 
            180                 185                 190         


Cys Leu Ser Pro Glu Ser Glu Ala Ile Thr Gln Asn Ala Gln Gly Leu 
        195                 200                 205             


Phe Ser Leu Glu Thr Ser Val Ile Val Arg Gly Gly Ala His Ser Asn 
    210                 215                 220                 


Val Ser Cys Ile Ile Gln Asn Pro Leu Leu Pro Gln Lys Lys Glu Phe 
225                 230                 235                 240 


Val Ile Gln Ile Ala Asp Val Phe Leu Pro Arg Met Ser Pro Trp Lys 
                245                 250                 255     


Lys Ala Phe Val Gly Thr Leu Val Val Leu Pro Leu Ser Leu Ile Val 
            260                 265                 270         


Leu Thr Met Leu Ala Leu Arg Tyr Phe Tyr Lys Leu Arg Ser Phe Gln 
        275                 280                 285             


Glu Lys Gln Val Lys Gln Gly Glu Glu Val Arg Glu Lys Leu Gln Thr 
    290                 295                 300                 


Glu Leu Asp Trp Arg Arg Ser Glu Gly Gln Ala Glu Trp Arg Ala Ala 
305                 310                 315                 320 


Gln Gln Tyr Ala Ala Asp Val Thr Leu Asp Pro Ala Thr Ala His Pro 
                325                 330                 335     


Ser Leu Glu Val Ser Asn Asn Gly Lys Thr Val Ser Ser Arg Leu Gly 
            340                 345                 350         


Val Pro Ser Ile Ala Ala Gly Asp Pro Gln Arg Phe Ser Glu Gln Thr 
        355                 360                 365             


Cys Val Leu Ser Arg Glu Arg Phe Ser Ser Gly Arg His Tyr Trp Glu 
    370                 375                 380                 


Val His Val Gly Arg Arg Ser Arg Trp Phe Leu Gly Ala Cys Leu Glu 
385                 390                 395                 400 


Ser Val Glu Arg Ser Gly Pro Ala Arg Leu Ser Pro Ala Ala Gly Tyr 
                405                 410                 415     


Trp Val Met Gly Leu Trp Asn Arg Cys Glu Tyr Phe Val Leu Asp Pro 
            420                 425                 430         


His Arg Val Ala Leu Ala Leu Arg Val Pro Pro Arg Arg Ile Gly Val 
        435                 440                 445             


Leu Leu Asp Tyr Glu Ala Gly Lys Leu Ser Phe Phe Asn Val Ser Asp 
    450                 455                 460                 


Gly Ser His Ile Phe Ser Phe Thr Asp Thr Phe Ser Gly Ala Leu Arg 
465                 470                 475                 480 


Ala Tyr Leu Arg Pro Arg Ala His Asp Gly Ser Glu His Pro Asp Pro 
                485                 490                 495     


Met Thr Ile Cys Ser Leu Pro Val Arg Gly Pro Gln Val Leu Glu Glu 
            500                 505                 510         


Asn Asp Asn Asp Asn Trp Leu Gln Pro Tyr Glu Pro Leu Asp Pro Ala 
        515                 520                 525             


Trp Ala Val Asn Glu Ala Val Ser 
    530                 535     


<210>  7
<211>  1505
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (91)..(1122)

<400>  7
ctttgcagag gaggtgagct caccaggact catctgccat ttcagacctt ttgctgctac       60

ctgccaggtg gcccccactg ctgacgagag atg gtg gac ctc tca gtc tcc cca       114
                                 Met Val Asp Leu Ser Val Ser Pro          
                                 1               5                        

gac tcc ttg aag cca gta tcg ctg acc agc agt ctt gtc ttc ctc atg        162
Asp Ser Leu Lys Pro Val Ser Leu Thr Ser Ser Leu Val Phe Leu Met           
    10                  15                  20                            

cac ctc ctc ctc ctt cag cct ggg gag ccg agc tca gag gtc aag gtg        210
His Leu Leu Leu Leu Gln Pro Gly Glu Pro Ser Ser Glu Val Lys Val           
25                  30                  35                  40            

cta ggc cct gag tat ccc atc ctg gcc ctc gtc ggg gag gag gtg gag        258
Leu Gly Pro Glu Tyr Pro Ile Leu Ala Leu Val Gly Glu Glu Val Glu           
                45                  50                  55                

ttc ccg tgc cac cta tgg cca cag ctg gat gcc cag caa atg gag atc        306
Phe Pro Cys His Leu Trp Pro Gln Leu Asp Ala Gln Gln Met Glu Ile           
            60                  65                  70                    

cgc tgg ttc cgg agt cag acc ttc aat gtg gta cac ctg tac cag gag        354
Arg Trp Phe Arg Ser Gln Thr Phe Asn Val Val His Leu Tyr Gln Glu           
        75                  80                  85                        

cag cag gag ctc cct ggc agg cag atg ccg gcg ttc cgg aac agg acc        402
Gln Gln Glu Leu Pro Gly Arg Gln Met Pro Ala Phe Arg Asn Arg Thr           
    90                  95                  100                           

aag ttg gtc aag gac gac atc gcc tat ggc agc gtg gtc ctg cag ctt        450
Lys Leu Val Lys Asp Asp Ile Ala Tyr Gly Ser Val Val Leu Gln Leu           
105                 110                 115                 120           

cac agc atc atc ccc tct gac aag ggc aca tat ggc tgc cgc ttc cac        498
His Ser Ile Ile Pro Ser Asp Lys Gly Thr Tyr Gly Cys Arg Phe His           
                125                 130                 135               

tcc gac aac ttc tct ggc gaa gct ctc tgg gaa ctg gag gta gca ggg        546
Ser Asp Asn Phe Ser Gly Glu Ala Leu Trp Glu Leu Glu Val Ala Gly           
            140                 145                 150                   

ctg ggc tca gac cct cac ctc tcc ctt gag ggc ttc aag gaa gga ggc        594
Leu Gly Ser Asp Pro His Leu Ser Leu Glu Gly Phe Lys Glu Gly Gly           
        155                 160                 165                       

att cag ctg agg ctc aga tcc agt ggc tgg tac ccc aag cct aag gtt        642
Ile Gln Leu Arg Leu Arg Ser Ser Gly Trp Tyr Pro Lys Pro Lys Val           
    170                 175                 180                           

cag tgg aga gac cac cag gga cag tgc ctg cct cca gag ttt gaa gcc        690
Gln Trp Arg Asp His Gln Gly Gln Cys Leu Pro Pro Glu Phe Glu Ala           
185                 190                 195                 200           

atc gtc tgg gat gcc cag gac ctg ttc agt ctg gaa aca tct gtg gtt        738
Ile Val Trp Asp Ala Gln Asp Leu Phe Ser Leu Glu Thr Ser Val Val           
                205                 210                 215               

gtc cga gcg gga gcc ctc agc aat gtg tcc gtc tcc atc cag aat ctc        786
Val Arg Ala Gly Ala Leu Ser Asn Val Ser Val Ser Ile Gln Asn Leu           
            220                 225                 230                   

ctc ttg agc cag aag aaa gag ttg gtg gtc cag ata gca gac gtg ttc        834
Leu Leu Ser Gln Lys Lys Glu Leu Val Val Gln Ile Ala Asp Val Phe           
        235                 240                 245                       

gta ccc gga gcc tct gcg tgg aag agc gcg ttc gtc gcg acc ctg ccg        882
Val Pro Gly Ala Ser Ala Trp Lys Ser Ala Phe Val Ala Thr Leu Pro           
    250                 255                 260                           

ctg ctg ttg gtc ctc gcg gcg ctg gcg ctg ggc gtc ctc cgg aag cag        930
Leu Leu Leu Val Leu Ala Ala Leu Ala Leu Gly Val Leu Arg Lys Gln           
265                 270                 275                 280           

cgg aga agc cga gaa aag ctg agg aag cag gcg gag aag aga caa gag        978
Arg Arg Ser Arg Glu Lys Leu Arg Lys Gln Ala Glu Lys Arg Gln Glu           
                285                 290                 295               

aaa ctc act gca gag ctg gaa aag ctt cag aca gag ctt gac tgg aga       1026
Lys Leu Thr Ala Glu Leu Glu Lys Leu Gln Thr Glu Leu Asp Trp Arg           
            300                 305                 310                   

cgg gct gaa ggc cag gct gag tgc ttc gtt tta gcc agc cac cct cct       1074
Arg Ala Glu Gly Gln Ala Glu Cys Phe Val Leu Ala Ser His Pro Pro           
        315                 320                 325                       

gga gaa ggt atc cag gct gcc tct aac tcc aca aca aca ctg aat gca       1122
Gly Glu Gly Ile Gln Ala Ala Ser Asn Ser Thr Thr Thr Leu Asn Ala           
    330                 335                 340                           

tagtctcaaa cgtgttgcct tacggcgctg tgtggagatt tctctggggt ttgcaacctc     1182

tgaatgctga gaagattgag catctctgta tatgctagtt ggctctgggg acttcctcta     1242

ctgaaaattg ccagctcaca tcactgaccc atttttctta tgggatggct gtcttttatt     1302

attaacagga atattatata tctgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgag     1362

attaatccct catgggtaaa catcgtgaat tccttcttct gttgtgccat ctgccattag     1422

ctttgtccat agttcccctt attgaaaagg aattattaat tttgataaaa cataatccat     1482

caaaaaaaaa aaaaaaaaaa aaa                                             1505


<210>  8
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val Asp Leu Ser Val Ser Pro Asp Ser Leu Lys Pro Val Ser Leu 
1               5                   10                  15      


Thr Ser Ser Leu Val Phe Leu Met His Leu Leu Leu Leu Gln Pro Gly 
            20                  25                  30          


Glu Pro Ser Ser Glu Val Lys Val Leu Gly Pro Glu Tyr Pro Ile Leu 
        35                  40                  45              


Ala Leu Val Gly Glu Glu Val Glu Phe Pro Cys His Leu Trp Pro Gln 
    50                  55                  60                  


Leu Asp Ala Gln Gln Met Glu Ile Arg Trp Phe Arg Ser Gln Thr Phe 
65                  70                  75                  80  


Asn Val Val His Leu Tyr Gln Glu Gln Gln Glu Leu Pro Gly Arg Gln 
                85                  90                  95      


Met Pro Ala Phe Arg Asn Arg Thr Lys Leu Val Lys Asp Asp Ile Ala 
            100                 105                 110         


Tyr Gly Ser Val Val Leu Gln Leu His Ser Ile Ile Pro Ser Asp Lys 
        115                 120                 125             


Gly Thr Tyr Gly Cys Arg Phe His Ser Asp Asn Phe Ser Gly Glu Ala 
    130                 135                 140                 


Leu Trp Glu Leu Glu Val Ala Gly Leu Gly Ser Asp Pro His Leu Ser 
145                 150                 155                 160 


Leu Glu Gly Phe Lys Glu Gly Gly Ile Gln Leu Arg Leu Arg Ser Ser 
                165                 170                 175     


Gly Trp Tyr Pro Lys Pro Lys Val Gln Trp Arg Asp His Gln Gly Gln 
            180                 185                 190         


Cys Leu Pro Pro Glu Phe Glu Ala Ile Val Trp Asp Ala Gln Asp Leu 
        195                 200                 205             


Phe Ser Leu Glu Thr Ser Val Val Val Arg Ala Gly Ala Leu Ser Asn 
    210                 215                 220                 


Val Ser Val Ser Ile Gln Asn Leu Leu Leu Ser Gln Lys Lys Glu Leu 
225                 230                 235                 240 


Val Val Gln Ile Ala Asp Val Phe Val Pro Gly Ala Ser Ala Trp Lys 
                245                 250                 255     


Ser Ala Phe Val Ala Thr Leu Pro Leu Leu Leu Val Leu Ala Ala Leu 
            260                 265                 270         


Ala Leu Gly Val Leu Arg Lys Gln Arg Arg Ser Arg Glu Lys Leu Arg 
        275                 280                 285             


Lys Gln Ala Glu Lys Arg Gln Glu Lys Leu Thr Ala Glu Leu Glu Lys 
    290                 295                 300                 


Leu Gln Thr Glu Leu Asp Trp Arg Arg Ala Glu Gly Gln Ala Glu Cys 
305                 310                 315                 320 


Phe Val Leu Ala Ser His Pro Pro Gly Glu Gly Ile Gln Ala Ala Ser 
                325                 330                 335     


Asn Ser Thr Thr Thr Leu Asn Ala 
            340                 


<210>  9
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  9

Gly Gly Gly Gly Ser 
1               5   


<210>  10
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  10

Gly Gly Gly Gly Ser Asn 
1               5       


<210>  11
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  11

Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10          


<210>  12
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  12

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  


<210>  13
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  13

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Ser Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  14
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  14

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  


<210>  15
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  15

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  16
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  16

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Glu Phe 
1               5                   10                  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  17

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  18
<211>  1500
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence encoding a fusion protein


<220>
<221>  CDS
<222>  (1)..(1500)

<400>  18
atg gtg gac ctc tca gtc tcc cca gac tcc ttg aag cca gta tcg ctg         48
Met Val Asp Leu Ser Val Ser Pro Asp Ser Leu Lys Pro Val Ser Leu           
1               5                   10                  15                

acc agc agt ctt gtc ttc ctc atg cac ctc ctc ctc ctt cag cct ggg         96
Thr Ser Ser Leu Val Phe Leu Met His Leu Leu Leu Leu Gln Pro Gly           
            20                  25                  30                    

gag ccg agc tca gag gtc aag gtg cta ggc cct gag tat ccc atc ctg        144
Glu Pro Ser Ser Glu Val Lys Val Leu Gly Pro Glu Tyr Pro Ile Leu           
        35                  40                  45                        

gcc ctc gtc ggg gag gag gtg gag ttc ccg tgc cac cta tgg cca cag        192
Ala Leu Val Gly Glu Glu Val Glu Phe Pro Cys His Leu Trp Pro Gln           
    50                  55                  60                            

ctg gat gcc cag caa atg gag atc cgc tgg ttc cgg agt cag acc ttc        240
Leu Asp Ala Gln Gln Met Glu Ile Arg Trp Phe Arg Ser Gln Thr Phe           
65                  70                  75                  80            

aat gtg gta cac ctg tac cag gag cag cag gag ctc cct ggc agg cag        288
Asn Val Val His Leu Tyr Gln Glu Gln Gln Glu Leu Pro Gly Arg Gln           
                85                  90                  95                

atg ccg gcg ttc cgg aac agg acc aag ttg gtc aag gac gac atc gcc        336
Met Pro Ala Phe Arg Asn Arg Thr Lys Leu Val Lys Asp Asp Ile Ala           
            100                 105                 110                   

tat ggc agc gtg gtc ctg cag ctt cac agc atc atc ccc tct gac aag        384
Tyr Gly Ser Val Val Leu Gln Leu His Ser Ile Ile Pro Ser Asp Lys           
        115                 120                 125                       

ggc aca tat ggc tgc cgc ttc cac tcc gac aac ttc tct ggc gaa gct        432
Gly Thr Tyr Gly Cys Arg Phe His Ser Asp Asn Phe Ser Gly Glu Ala           
    130                 135                 140                           

ctc tgg gaa ctg gag gta gca ggg ctg ggc tca gac cct cac ctc tcc        480
Leu Trp Glu Leu Glu Val Ala Gly Leu Gly Ser Asp Pro His Leu Ser           
145                 150                 155                 160           

ctt gag ggc ttc aag gaa gga ggc att cag ctg agg ctc aga tcc agt        528
Leu Glu Gly Phe Lys Glu Gly Gly Ile Gln Leu Arg Leu Arg Ser Ser           
                165                 170                 175               

ggc tgg tac ccc aag cct aag gtt cag tgg aga gac cac cag gga cag        576
Gly Trp Tyr Pro Lys Pro Lys Val Gln Trp Arg Asp His Gln Gly Gln           
            180                 185                 190                   

tgc ctg cct cca gag ttt gaa gcc atc gtc tgg gat gcc cag gac ctg        624
Cys Leu Pro Pro Glu Phe Glu Ala Ile Val Trp Asp Ala Gln Asp Leu           
        195                 200                 205                       

ttc agt ctg gaa aca tct gtg gtt gtc cga gcg gga gcc ctc agc aat        672
Phe Ser Leu Glu Thr Ser Val Val Val Arg Ala Gly Ala Leu Ser Asn           
    210                 215                 220                           

gtg tcc gtc tcc atc cag aat ctc ctc ttg agc cag aag aaa gag ttg        720
Val Ser Val Ser Ile Gln Asn Leu Leu Leu Ser Gln Lys Lys Glu Leu           
225                 230                 235                 240           

gtg gtc cag ata gca gac gtg ttc gta ccc gga gcc tct gcg tgg aag        768
Val Val Gln Ile Ala Asp Val Phe Val Pro Gly Ala Ser Ala Trp Lys           
                245                 250                 255               

agc gga ggt gga ggc tcc gga ggt gga ggt tcc ggt gga ggt gga tcc        816
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser           
            260                 265                 270                   

gac aaa act cac aca tgt cca ccg tgc cca gca cct gaa ctc ctg ggg        864
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly           
        275                 280                 285                       

gga ccg tca gtt ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg        912
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met           
    290                 295                 300                           

atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac        960
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His           
305                 310                 315                 320           

gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg       1008
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val           
                325                 330                 335               

cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg tac       1056
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr           
            340                 345                 350                   

cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc       1104
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly           
        355                 360                 365                       

aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc       1152
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile           
    370                 375                 380                           

gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg       1200
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val           
385                 390                 395                 400           

tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc agc       1248
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser           
                405                 410                 415               

ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag       1296
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu           
            420                 425                 430                   

tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct ccc       1344
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro           
        435                 440                 445                       

gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg       1392
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val           
    450                 455                 460                           

gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg       1440
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met           
465                 470                 475                 480           

cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct       1488
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser           
                485                 490                 495               

ccg ggt aaa tga                                                       1500
Pro Gly Lys                                                               
                                                                          


<210>  19
<211>  499
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  19

Met Val Asp Leu Ser Val Ser Pro Asp Ser Leu Lys Pro Val Ser Leu 
1               5                   10                  15      


Thr Ser Ser Leu Val Phe Leu Met His Leu Leu Leu Leu Gln Pro Gly 
            20                  25                  30          


Glu Pro Ser Ser Glu Val Lys Val Leu Gly Pro Glu Tyr Pro Ile Leu 
        35                  40                  45              


Ala Leu Val Gly Glu Glu Val Glu Phe Pro Cys His Leu Trp Pro Gln 
    50                  55                  60                  


Leu Asp Ala Gln Gln Met Glu Ile Arg Trp Phe Arg Ser Gln Thr Phe 
65                  70                  75                  80  


Asn Val Val His Leu Tyr Gln Glu Gln Gln Glu Leu Pro Gly Arg Gln 
                85                  90                  95      


Met Pro Ala Phe Arg Asn Arg Thr Lys Leu Val Lys Asp Asp Ile Ala 
            100                 105                 110         


Tyr Gly Ser Val Val Leu Gln Leu His Ser Ile Ile Pro Ser Asp Lys 
        115                 120                 125             


Gly Thr Tyr Gly Cys Arg Phe His Ser Asp Asn Phe Ser Gly Glu Ala 
    130                 135                 140                 


Leu Trp Glu Leu Glu Val Ala Gly Leu Gly Ser Asp Pro His Leu Ser 
145                 150                 155                 160 


Leu Glu Gly Phe Lys Glu Gly Gly Ile Gln Leu Arg Leu Arg Ser Ser 
                165                 170                 175     


Gly Trp Tyr Pro Lys Pro Lys Val Gln Trp Arg Asp His Gln Gly Gln 
            180                 185                 190         


Cys Leu Pro Pro Glu Phe Glu Ala Ile Val Trp Asp Ala Gln Asp Leu 
        195                 200                 205             


Phe Ser Leu Glu Thr Ser Val Val Val Arg Ala Gly Ala Leu Ser Asn 
    210                 215                 220                 


Val Ser Val Ser Ile Gln Asn Leu Leu Leu Ser Gln Lys Lys Glu Leu 
225                 230                 235                 240 


Val Val Gln Ile Ala Asp Val Phe Val Pro Gly Ala Ser Ala Trp Lys 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys 
            


<210>  20
<211>  2070
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence encoding a fusion protein


<220>
<221>  CDS
<222>  (1)..(2070)

<400>  20
atg gtg gat tgc cca cgg tat agt cta tct ggc gtg gct gcc tcc ttc         48
Met Val Asp Cys Pro Arg Tyr Ser Leu Ser Gly Val Ala Ala Ser Phe           
1               5                   10                  15                

ctc ttc gtc ctg ctg act ata aag cac cca gat gac ttc aga gtg gtc         96
Leu Phe Val Leu Leu Thr Ile Lys His Pro Asp Asp Phe Arg Val Val           
            20                  25                  30                    

ggt cct aac ctc cca atc ctg gct aaa gtc ggg gaa gat gcc ctg cta        144
Gly Pro Asn Leu Pro Ile Leu Ala Lys Val Gly Glu Asp Ala Leu Leu           
        35                  40                  45                        

acg tgt cag ctc ctc ccc aag agg acc acg gca cac atg gag gtg agg        192
Thr Cys Gln Leu Leu Pro Lys Arg Thr Thr Ala His Met Glu Val Arg           
    50                  55                  60                            

tgg tac cgc tcc gac cct gcc atg cca gtg att atg tac cgg gat gga        240
Trp Tyr Arg Ser Asp Pro Ala Met Pro Val Ile Met Tyr Arg Asp Gly           
65                  70                  75                  80            

gct gtg gtg act ggg cta ccg atg gag ggg tac gga ggc cgg gca gag        288
Ala Val Val Thr Gly Leu Pro Met Glu Gly Tyr Gly Gly Arg Ala Glu           
                85                  90                  95                

tgg atg gag gac agc act gaa gag ggc agt gtg gct ctg aag att cgc        336
Trp Met Glu Asp Ser Thr Glu Glu Gly Ser Val Ala Leu Lys Ile Arg           
            100                 105                 110                   

cag gtc cag cca agt gac gat ggc cag tac tgg tgc cgc ttc cag gag        384
Gln Val Gln Pro Ser Asp Asp Gly Gln Tyr Trp Cys Arg Phe Gln Glu           
        115                 120                 125                       

ggg gac tac tgg aga gag aca agc gtg cta ctc caa gtg gct gct cta        432
Gly Asp Tyr Trp Arg Glu Thr Ser Val Leu Leu Gln Val Ala Ala Leu           
    130                 135                 140                           

gga tct tcc cca aat atc cat gtg gag gga ctt gga gaa gga gag gtc        480
Gly Ser Ser Pro Asn Ile His Val Glu Gly Leu Gly Glu Gly Glu Val           
145                 150                 155                 160           

caa ctt gta tgc acg tcc cga ggc tgg ttc cct gag cct gag gtg cac        528
Gln Leu Val Cys Thr Ser Arg Gly Trp Phe Pro Glu Pro Glu Val His           
                165                 170                 175               

tgg gaa ggc atc tgg gga gaa aag ttg atg agt ttc tct gag aat cat        576
Trp Glu Gly Ile Trp Gly Glu Lys Leu Met Ser Phe Ser Glu Asn His           
            180                 185                 190                   

gtg cca ggt gaa gat ggg cta ttc tat gtg gaa gac aca ctg atg gtc        624
Val Pro Gly Glu Asp Gly Leu Phe Tyr Val Glu Asp Thr Leu Met Val           
        195                 200                 205                       

agg aat gac agt gta gag acc att tcc tgc ttc atc tac agc cat ggc        672
Arg Asn Asp Ser Val Glu Thr Ile Ser Cys Phe Ile Tyr Ser His Gly           
    210                 215                 220                           

ctc aga gag acc cag gag gcc acc atc gct ctg tca gag agg ctc cag        720
Leu Arg Glu Thr Gln Glu Ala Thr Ile Ala Leu Ser Glu Arg Leu Gln           
225                 230                 235                 240           

acc gaa ctg gtt tcc gtt agc gta atc gga cat tcc cag ccc agc cct        768
Thr Glu Leu Val Ser Val Ser Val Ile Gly His Ser Gln Pro Ser Pro           
                245                 250                 255               

gtt caa gtc gga gag aac ata gaa tta act tgt cac ctc tca cct caa        816
Val Gln Val Gly Glu Asn Ile Glu Leu Thr Cys His Leu Ser Pro Gln           
            260                 265                 270                   

acg gat gct cag aac tta gag gtg agg tgg ctc cga tcc cgc tat tac        864
Thr Asp Ala Gln Asn Leu Glu Val Arg Trp Leu Arg Ser Arg Tyr Tyr           
        275                 280                 285                       

cct gca gtc cac gtg tat gca aat ggc acc cac gtg gct gga gag cag        912
Pro Ala Val His Val Tyr Ala Asn Gly Thr His Val Ala Gly Glu Gln           
    290                 295                 300                           

atg gta gaa tac aaa ggg agg act tca ttg gtg act gat gcc atc cac        960
Met Val Glu Tyr Lys Gly Arg Thr Ser Leu Val Thr Asp Ala Ile His           
305                 310                 315                 320           

gag gga aaa ctg acc ctg cag att cac aat gcc aga act tcg gat gaa       1008
Glu Gly Lys Leu Thr Leu Gln Ile His Asn Ala Arg Thr Ser Asp Glu           
                325                 330                 335               

ggg cag tac cgg tgc ctt ttt gga aaa gat ggt gtc tac cag gag gcc       1056
Gly Gln Tyr Arg Cys Leu Phe Gly Lys Asp Gly Val Tyr Gln Glu Ala           
            340                 345                 350                   

cgt gtg gat gtg cag gtg acg gcg gtg ggt tcc acc cca cgg atc acc       1104
Arg Val Asp Val Gln Val Thr Ala Val Gly Ser Thr Pro Arg Ile Thr           
        355                 360                 365                       

agg gag gtc ttg aaa gat gga ggc atg cag ctg agg tgt acg tct gat       1152
Arg Glu Val Leu Lys Asp Gly Gly Met Gln Leu Arg Cys Thr Ser Asp           
    370                 375                 380                           

ggg tgg ttc cca cgg ccc cat gtg cag tgg agg gac aga gat gga aag       1200
Gly Trp Phe Pro Arg Pro His Val Gln Trp Arg Asp Arg Asp Gly Lys           
385                 390                 395                 400           

aca atg cca tcg ttt tcc gag gcc ttt cag caa ggg agc cag gag ctg       1248
Thr Met Pro Ser Phe Ser Glu Ala Phe Gln Gln Gly Ser Gln Glu Leu           
                405                 410                 415               

ttc cag gtg gag aca ctt ctg ctg gtc aca aac ggc tcc atg gtg aat       1296
Phe Gln Val Glu Thr Leu Leu Leu Val Thr Asn Gly Ser Met Val Asn           
            420                 425                 430                   

gtg acc tgc tcc atc agc ctc cct ctg ggc cag gag aaa aca gcc cgt       1344
Val Thr Cys Ser Ile Ser Leu Pro Leu Gly Gln Glu Lys Thr Ala Arg           
        435                 440                 445                       

ttc cct ctc tca gac tcc aag tac gta gag ccc aga tct tgt gac aaa       1392
Phe Pro Leu Ser Asp Ser Lys Tyr Val Glu Pro Arg Ser Cys Asp Lys           
    450                 455                 460                           

act cac aca tgc cca ccg tgc cca gca cct gaa gcc gag ggc gcg ccg       1440
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro           
465                 470                 475                 480           

tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc       1488
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser           
                485                 490                 495               

cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac       1536
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp           
            500                 505                 510                   

cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat       1584
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn           
        515                 520                 525                       

gcc aag aca aag ccg cgg gag gag cag tac aac agc acg tac cgt gtg       1632
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val           
    530                 535                 540                           

gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag gag       1680
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu           
545                 550                 555                 560           

tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa       1728
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys           
                565                 570                 575               

acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc       1776
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr           
            580                 585                 590                   

ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg acc       1824
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr           
        595                 600                 605                       

tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag       1872
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu           
    610                 615                 620                           

agc aat ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg ctg       1920
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu           
625                 630                 635                 640           

gac tcc gac ggc tcc ttc ttc ctc tat agc aag ctc acc gtg gac aag       1968
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys           
                645                 650                 655               

agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag       2016
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu           
            660                 665                 670                   

gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg ggt       2064
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly           
        675                 680                 685                       

aaa tga                                                               2070
Lys                                                                       
                                                                          


<210>  21
<211>  689
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  21

Met Val Asp Cys Pro Arg Tyr Ser Leu Ser Gly Val Ala Ala Ser Phe 
1               5                   10                  15      


Leu Phe Val Leu Leu Thr Ile Lys His Pro Asp Asp Phe Arg Val Val 
            20                  25                  30          


Gly Pro Asn Leu Pro Ile Leu Ala Lys Val Gly Glu Asp Ala Leu Leu 
        35                  40                  45              


Thr Cys Gln Leu Leu Pro Lys Arg Thr Thr Ala His Met Glu Val Arg 
    50                  55                  60                  


Trp Tyr Arg Ser Asp Pro Ala Met Pro Val Ile Met Tyr Arg Asp Gly 
65                  70                  75                  80  


Ala Val Val Thr Gly Leu Pro Met Glu Gly Tyr Gly Gly Arg Ala Glu 
                85                  90                  95      


Trp Met Glu Asp Ser Thr Glu Glu Gly Ser Val Ala Leu Lys Ile Arg 
            100                 105                 110         


Gln Val Gln Pro Ser Asp Asp Gly Gln Tyr Trp Cys Arg Phe Gln Glu 
        115                 120                 125             


Gly Asp Tyr Trp Arg Glu Thr Ser Val Leu Leu Gln Val Ala Ala Leu 
    130                 135                 140                 


Gly Ser Ser Pro Asn Ile His Val Glu Gly Leu Gly Glu Gly Glu Val 
145                 150                 155                 160 


Gln Leu Val Cys Thr Ser Arg Gly Trp Phe Pro Glu Pro Glu Val His 
                165                 170                 175     


Trp Glu Gly Ile Trp Gly Glu Lys Leu Met Ser Phe Ser Glu Asn His 
            180                 185                 190         


Val Pro Gly Glu Asp Gly Leu Phe Tyr Val Glu Asp Thr Leu Met Val 
        195                 200                 205             


Arg Asn Asp Ser Val Glu Thr Ile Ser Cys Phe Ile Tyr Ser His Gly 
    210                 215                 220                 


Leu Arg Glu Thr Gln Glu Ala Thr Ile Ala Leu Ser Glu Arg Leu Gln 
225                 230                 235                 240 


Thr Glu Leu Val Ser Val Ser Val Ile Gly His Ser Gln Pro Ser Pro 
                245                 250                 255     


Val Gln Val Gly Glu Asn Ile Glu Leu Thr Cys His Leu Ser Pro Gln 
            260                 265                 270         


Thr Asp Ala Gln Asn Leu Glu Val Arg Trp Leu Arg Ser Arg Tyr Tyr 
        275                 280                 285             


Pro Ala Val His Val Tyr Ala Asn Gly Thr His Val Ala Gly Glu Gln 
    290                 295                 300                 


Met Val Glu Tyr Lys Gly Arg Thr Ser Leu Val Thr Asp Ala Ile His 
305                 310                 315                 320 


Glu Gly Lys Leu Thr Leu Gln Ile His Asn Ala Arg Thr Ser Asp Glu 
                325                 330                 335     


Gly Gln Tyr Arg Cys Leu Phe Gly Lys Asp Gly Val Tyr Gln Glu Ala 
            340                 345                 350         


Arg Val Asp Val Gln Val Thr Ala Val Gly Ser Thr Pro Arg Ile Thr 
        355                 360                 365             


Arg Glu Val Leu Lys Asp Gly Gly Met Gln Leu Arg Cys Thr Ser Asp 
    370                 375                 380                 


Gly Trp Phe Pro Arg Pro His Val Gln Trp Arg Asp Arg Asp Gly Lys 
385                 390                 395                 400 


Thr Met Pro Ser Phe Ser Glu Ala Phe Gln Gln Gly Ser Gln Glu Leu 
                405                 410                 415     


Phe Gln Val Glu Thr Leu Leu Leu Val Thr Asn Gly Ser Met Val Asn 
            420                 425                 430         


Val Thr Cys Ser Ile Ser Leu Pro Leu Gly Gln Glu Lys Thr Ala Arg 
        435                 440                 445             


Phe Pro Leu Ser Asp Ser Lys Tyr Val Glu Pro Arg Ser Cys Asp Lys 
    450                 455                 460                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro 
465                 470                 475                 480 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                485                 490                 495     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            500                 505                 510         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        515                 520                 525             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    530                 535                 540                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
545                 550                 555                 560 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                565                 570                 575     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            580                 585                 590         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        595                 600                 605             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    610                 615                 620                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
625                 630                 635                 640 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                645                 650                 655     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            660                 665                 670         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        675                 680                 685             


Lys 
    


