                         SEQUENCE LISTING

<110>  Scil Technology GmbH
 
<120>  Stable MIA/CD-RAP formulation

<130>  SCI13586PCT


<150>  EP10161160.6
<151>  2010/04/27

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Pro Met Pro Lys Leu Ala Asp Arg Lys Leu Cys Ala Asp Gln Glu 
1               5                   10                  15      


Cys Ser His Pro Ile Ser Met Ala Val Ala Leu Gln Asp Tyr Met Ala 
            20                  25                  30          


Pro Asp Cys Arg Phe Leu Thr Ile His Arg Gly Gln Val Val Tyr Val 
        35                  40                  45              


Phe Ser Lys Leu Lys Gly Arg Gly Arg Leu Phe Trp Gly Gly Ser Val 
    50                  55                  60                  


Gln Gly Asp Tyr Tyr Gly Asp Leu Ala Ala Arg Leu Gly Tyr Phe Pro 
65                  70                  75                  80  


Ser Ser Ile Val Arg Glu Asp Gln Thr Leu Lys Pro Gly Lys Val Asp 
                85                  90                  95      


Val Lys Thr Asp Lys Trp Asp Phe Tyr Cys Gln 
            100                 105         


<210>  2
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  generic human CD-RAP sequence


<220>
<221>  misc_feature
<222>  (2)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(23)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (25)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (38)..(50)
<223>  Xaa can be any naturally occurring amino acid, wherein the number 
       of any naturally occurring amino acid may vary from 11-13

<220>
<221>  misc_feature
<222>  (52)..(69)
<223>  Xaa can be any naturally occurring amino acid, wherein the number 
       of any naturally occurring amino acid may vary from 7-18

<220>
<221>  misc_feature
<222>  (71)..(74)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (76)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Cys Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa Xaa Val Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Cys Xaa 
        


<210>  3
<211>  100
<212>  PRT
<213>  Artificial

<220>
<223>  generic human CD-RAP sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(38)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (44)..(52)
<223>  Xaa can be any naturally occurring amino acid, wherein the number 
       of any naturally occurring amino acid may vary from 7-9

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (57)..(69)
<223>  Xaa can be any naturally occurring amino acid, wherein the number 
       of any naturally occurring amino acid may vary from 5-13

<220>
<221>  misc_feature
<222>  (74)..(76)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (78)..(95)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Lys Xaa Cys Xaa Asp Xaa Glu Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Asp Xaa Xaa Xaa Pro Asp Cys Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Xaa Lys Leu Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Trp Xaa Gly Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Gly Tyr Phe Pro Xaa Xaa Xaa Val Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp 
                85                  90                  95      


Phe Xaa Cys Xaa 
            100 


<210>  4
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  generic human CD-RAP sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(41)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (44)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(67)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (72)..(93)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Lys Xaa Cys Xaa Asp Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Ala Xaa Xaa Asp Xaa Xaa Xaa Pro Asp Cys Arg Phe Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Gly Xaa Val Xaa Xaa Xaa Xaa Xaa Lys Leu Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Trp Xaa Gly Ser Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Gly Tyr Phe Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Phe Xaa 
                85                  90                  95      


Cys Gln 
        


<210>  5
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence for human MMP-13 gene

<400>  5
gggttcctga tgtgggtgaa ta                                                22


<210>  6
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence for human MMP-13 gene

<400>  6
gccatcgtga agtctggta                                                    19





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