                         SEQUENCE LISTING

<110>  EXTERNAUTICS S.p.A.
 
<120>  Tumor marker and methods of use thereof

<130>  1335PCT

<160>  15    

<170>  PatentIn version 3.3

<210>  1
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Asn Lys Ala Met Tyr Leu His Thr Val Ser Asp Cys Asp Thr 
1               5                   10                  15      


Ser Ser Ile Cys Glu Asp Ser Phe Asp Gly Arg Ser Leu Ser Lys Leu 
            20                  25                  30          


Asn Leu Cys Glu Asp Val Ser Arg Pro Arg Ser Ser Pro Asp Asp Leu 
        35                  40                  45              


Lys Ala Leu Thr Arg Asn Val Asn Arg Leu Asn Glu Ser Phe Arg Asp 
    50                  55                  60                  


Leu Gln Leu Arg Leu Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu 
65                  70                  75                  80  


Gln Val Trp Lys Val Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu 
                85                  90                  95      


Leu Ala Leu Ala Gly Ala Val Gln Arg Leu Glu Gly Ala Leu Trp Gly 
            100                 105                 110         


Leu Gln Ala Gln Ala Val Gln Thr Glu Gln Ala Val Ala Leu Leu Arg 
        115                 120                 125             


Asp Arg Thr Gly Gln Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr Gln 
    130                 135                 140                 


Leu Gln Val Glu Ser Asn Ser Ser Gln Leu Leu Leu Arg Arg His Ala 
145                 150                 155                 160 


Gly Leu Leu Asp Gly Leu Ala Arg Arg Val Gly Ile Leu Gly Glu Glu 
                165                 170                 175     


Leu Ala Asp Val Gly Gly Val Leu Arg Gly Leu Asn His Ser Leu Ser 
            180                 185                 190         


Tyr Asp Val Ala Leu His Arg Thr Arg Leu Gln Asp Leu Arg Val Leu 
        195                 200                 205             


Val Ser Asn Ala Ser Glu Asp Thr Arg Arg Leu Arg Leu Ala His Val 
    210                 215                 220                 


Gly Met Glu Leu Gln Leu Lys Gln Glu Leu Ala Met Leu Asn Ala Val 
225                 230                 235                 240 


Thr Glu Asp Leu Arg Leu Lys Asp Trp Glu His Ser Ile Ala Leu Arg 
                245                 250                 255     


Asn Ile Ser Leu Ala Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly 
            260                 265                 270         


Asp Glu Gly Lys Glu Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu 
        275                 280                 285             


Arg Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys 
    290                 295                 300                 


Gly Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly 
305                 310                 315                 320 


Phe Lys Gly Asp Arg Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp 
                325                 330                 335     


Arg Ala Gly Asp Ala Ser Lys Asp Ile Leu Leu Gly Pro Trp Asp Met 
            340                 345                 350         


Val Leu Ala Gln Gly 
        355         


<210>  2
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Asn Lys Ala Met Tyr Leu His Thr Val Ser Asp Cys Asp Thr 
1               5                   10                  15      


Ser Ser Ile Cys Glu Asp Ser Phe Asp Gly Arg Ser Leu Ser Lys Leu 
            20                  25                  30          


Asn Leu Cys Glu Asp Gly Pro Cys His Lys Arg Arg Ala Ser Ile Cys 
        35                  40                  45              


Cys Thr Gln Leu Gly Ser Leu Ser Ala Leu Lys His Ala Val Leu Gly 
    50                  55                  60                  


Leu Tyr Leu Leu Val Phe Leu Ile Leu Val Gly Ile Phe Ile Leu Ala 
65                  70                  75                  80  


Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu Gly 
                85                  90                  95      


Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly Glu 
            100                 105                 110         


Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys Leu 
        115                 120                 125             


Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg Gly 
    130                 135                 140                 


Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Ala Gly Asp Ala Ser 
145                 150                 155                 160 


Gly Val Glu Ala Pro Met Met Ile Arg Leu Val Asn Gly Ser Gly Pro 
                165                 170                 175     


His Glu Gly Arg Val Glu Val Tyr His Asp Arg Arg Trp Gly Thr Val 
            180                 185                 190         


Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp Val Val Cys Arg Met 
        195                 200                 205             


Leu Gly Phe Arg Gly Val Glu Glu Val Tyr Arg Thr Ala Arg Phe Gly 
    210                 215                 220                 


Gln Gly Thr Gly Arg Ile Trp Met Asp Asp Val Ala Cys Lys Gly Thr 
225                 230                 235                 240 


Glu Glu Thr Ile Phe Arg Cys Ser Phe Ser Lys Trp Gly Val Thr Asn 
                245                 250                 255     


Cys Gly His Ala Glu Asp Ala Ser Val Thr Cys Asn Arg His 
            260                 265                 270 


<210>  3
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Asn Lys Ala Met Tyr Leu His Thr Val Ser Asp Cys Asp Thr 
1               5                   10                  15      


Ser Ser Ile Cys Glu Asp Ser Phe Asp Gly Arg Ser Leu Ser Lys Leu 
            20                  25                  30          


Asn Leu Cys Glu Asp Gly Pro Cys His Lys Arg Arg Ala Ser Ile Cys 
        35                  40                  45              


Cys Thr Gln Leu Gly Ser Leu Ser Ala Leu Lys His Ala Val Leu Gly 
    50                  55                  60                  


Leu Tyr Leu Leu Val Phe Leu Ile Leu Val Gly Ile Phe Ile Leu Ala 
65                  70                  75                  80  


Val Ser Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys Ala Leu Thr Arg 
                85                  90                  95      


Asn Val Asn Arg Leu Asn Glu Ser Phe Arg Asp Leu Gln Leu Arg Leu 
            100                 105                 110         


Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln Val Trp Lys Val 
        115                 120                 125             


Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu Leu Ala Leu Ala Gly 
    130                 135                 140                 


Ala Val Gln Arg Leu Glu Gly Ala Leu Trp Gly Leu Gln Ala Gln Ala 
145                 150                 155                 160 


Val Gln Thr Glu Gln Ala Val Ala Leu Leu Arg Asp Arg Thr Gly Gln 
                165                 170                 175     


Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr Gln Leu Gln Val Glu Ser 
            180                 185                 190         


Asn Ser Ser Gln Leu Leu Leu Arg Arg His Ala Gly Leu Leu Asp Gly 
        195                 200                 205             


Leu Ala Arg Arg Val Gly Ile Leu Gly Glu Glu Leu Ala Asp Val Gly 
    210                 215                 220                 


Gly Val Leu Arg Gly Leu Asn His Ser Leu Ser Tyr Asp Val Ala Leu 
225                 230                 235                 240 


His Arg Thr Arg Leu Gln Asp Leu Arg Val Leu Val Ser Asn Ala Ser 
                245                 250                 255     


Glu Asp Thr Arg Arg Leu Arg Leu Ala His Val Gly Met Glu Leu Gln 
            260                 265                 270         


Leu Lys Gln Glu Leu Ala Met Leu Asn Ala Val Thr Glu Asp Leu Arg 
        275                 280                 285             


Leu Lys Asp Trp Glu His Ser Ile Ala Leu Arg Asn Ile Ser Leu Ala 
    290                 295                 300                 


Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu 
305                 310                 315                 320 


Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly 
                325                 330                 335     


Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys 
            340                 345                 350         


Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg 
        355                 360                 365             


Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Ala Gly Asp Ala 
    370                 375                 380                 


Ser Gly Val Glu Ala Pro Met Met Ile Arg Leu Val Asn Gly Ser Gly 
385                 390                 395                 400 


Pro His Glu Gly Arg Val Glu Val Tyr His Asp Arg Arg Trp Gly Thr 
                405                 410                 415     


Val Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp Val Val Cys Arg 
            420                 425                 430         


Met Leu Gly Phe Arg Gly Val Glu Glu Val Tyr Arg Thr Ala Arg Phe 
        435                 440                 445             


Gly Gln Gly Thr Gly Arg Ile Trp Met Asp Asp Val Ala Cys Lys Gly 
    450                 455                 460                 


Thr Glu Glu Thr Ile Phe Arg Cys Ser Phe Ser Lys Trp Gly Val Thr 
465                 470                 475                 480 


Asn Cys Gly His Ala Glu Asp Ala Ser Val Thr Cys Asn Arg His 
                485                 490                 495 


<210>  4
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Asn Lys Ala Met Tyr Leu His Thr Val Ser Asp Cys Asp Thr 
1               5                   10                  15      


Ser Ser Ile Cys Glu Asp Ser Phe Asp Gly Arg Ser Leu Ser Lys Leu 
            20                  25                  30          


Asn Leu Cys Glu Asp Gly Pro Cys His Lys Arg Arg Ala Ser Ile Cys 
        35                  40                  45              


Cys Thr Gln Leu Gly Ser Leu Ser Ala Leu Lys His Ala Val Leu Gly 
    50                  55                  60                  


Leu Tyr Leu Leu Val Phe Leu Ile Leu Val Gly Ile Phe Ile Leu Ala 
65                  70                  75                  80  


Val Ser Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys Ala Leu Thr Arg 
                85                  90                  95      


Asn Val Asn Arg Leu Asn Glu Ser Phe Arg Asp Leu Gln Leu Arg Leu 
            100                 105                 110         


Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln Val Trp Lys Val 
        115                 120                 125             


Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu Leu Ala Leu Ala Gly 
    130                 135                 140                 


Ala Val Gln Arg Leu Glu Gly Ala Leu Trp Gly Leu Gln Ala Gln Ala 
145                 150                 155                 160 


Val Gln Thr Glu Gln Ala Val Ala Leu Leu Arg Asp Arg Thr Gly Gln 
                165                 170                 175     


Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr Gln Leu Gln Val Glu Ser 
            180                 185                 190         


Asn Ser Ser Gln Leu Leu Leu Arg Arg His Ala Gly Leu Leu Asp Gly 
        195                 200                 205             


Leu Ala Arg Arg Val Gly Ile Leu Gly Glu Glu Leu Ala Asp Val Gly 
    210                 215                 220                 


Gly Val Leu Arg Gly Leu Asn His Ser Leu Ser Tyr Asp Val Ala Leu 
225                 230                 235                 240 


His Arg Thr Arg Leu Gln Asp Leu Arg Val Leu Val Ser Asn Ala Ser 
                245                 250                 255     


Glu Asp Thr Arg Arg Leu Arg Leu Ala His Val Gly Met Glu Leu Gln 
            260                 265                 270         


Leu Lys Gln Glu Leu Ala Met Leu Asn Ala Val Thr Glu Asp Leu Arg 
        275                 280                 285             


Leu Lys Asp Trp Glu His Ser Ile Ala Leu Arg Asn Ile Ser Leu Ala 
    290                 295                 300                 


Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu 
305                 310                 315                 320 


Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly 
                325                 330                 335     


Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys 
            340                 345                 350         


Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg 
        355                 360                 365             


Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Ala Gly Asp Ala 
    370                 375                 380                 


Ser Lys Asp Ile Leu Leu Gly Pro Trp Asp Met Val Leu Ala Gln Gly 
385                 390                 395                 400 


<210>  5
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Asn Ala Val Thr Glu Asp Leu Arg Leu Lys Asp Trp Glu His 
1               5                   10                  15      


Ser Ile Ala Leu Arg Asn Ile Ser Leu Ala Lys Gly Pro Pro Gly Pro 
            20                  25                  30          


Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu Gly Arg Pro Gly Ile Pro 
        35                  40                  45              


Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly 
    50                  55                  60                  


Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro 
65                  70                  75                  80  


Met Gly Met Arg Gly Phe Lys Gly Asp Arg Gly Pro Lys Gly Glu Lys 
                85                  90                  95      


Gly Glu Lys Gly Asp Arg Ala Gly Asp Ala Ser Gly Val Glu Ala Pro 
            100                 105                 110         


Met Met Ile Arg Leu Val Asn Gly Ser Gly Pro His Glu Gly Arg Val 
        115                 120                 125             


Glu Val Tyr His Asp Arg Arg Trp Gly Thr Val Cys Asp Asp Gly Trp 
    130                 135                 140                 


Asp Lys Lys Asp Gly Asp Val Val Cys Arg Met Leu Gly Phe Arg Gly 
145                 150                 155                 160 


Val Glu Glu Val Tyr Arg Thr Ala Arg Phe Gly Gln Gly Thr Gly Arg 
                165                 170                 175     


Ile Trp Met Asp Asp Val Ala Cys Lys Gly Thr Glu Glu Thr Ile Phe 
            180                 185                 190         


Arg Cys Ser Phe Ser Lys Trp Gly Val Thr Asn Cys Gly His Ala Glu 
        195                 200                 205             


Asp Ala Ser Val Thr Cys Asn Arg His 
    210                 215         


<210>  6
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  6

Thr Arg Asn Val Asn Arg Leu Asn Glu Ser Phe Arg Asp Leu Gln Leu 
1               5                   10                  15      


Arg Leu Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln Val Trp 
            20                  25                  30          


Lys Val Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu Leu Ala Leu 
        35                  40                  45              


Ala Gly Ala Val Gln Arg Leu Glu Gly Ala Leu Trp Gly Leu Arg Leu 
    50                  55                  60                  


Ala His Val Gly Met Glu Leu Gln Leu Lys Gln Glu Leu Ala Met Leu 
65                  70                  75                  80  


Asn Ala Val Thr Glu Asp Leu Arg Leu Lys Asp Trp Glu His Ser Ile 
                85                  90                  95      


Ala Leu Arg Asn Ile Ser Leu Ala Lys Gly Pro Pro Gly Pro Lys Gly 
            100                 105                 110         


Asp Gln Gly Asp Glu Gly Lys Glu Gly Arg Pro Gly Ile Pro Gly Leu 
        115                 120                 125             


Pro Gly Leu Arg Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly Leu Pro 
    130                 135                 140                 


Gly Pro Lys Gly Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly 
145                 150                 155                 160 


Met Arg Gly Phe Lys Gly Asp Arg Gly Pro Lys Gly Glu Lys Gly Glu 
                165                 170                 175     


Lys Gly Asp Arg Ala Gly Asp Ala Ser Gly Val Glu Ala 
            180                 185                 


<210>  7
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Asn Lys Ala Met Tyr Leu His Thr Val Ser Asp Cys Asp Thr 
1               5                   10                  15      


Ser Ser Ile Cys Glu Asp Ser Phe Asp Gly Arg Ser Leu Ser Lys Leu 
            20                  25                  30          


Asn Leu Cys Glu Asp Val Ser Arg Pro Arg Ser Ser Pro Asp Asp Leu 
        35                  40                  45              


Lys Ala Leu Thr Arg Asn Val Asn Arg Leu Asn Glu Ser Phe Arg Asp 
    50                  55                  60                  


Leu Gln Leu Arg Leu Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu 
65                  70                  75                  80  


Gln Val Trp Lys Val Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu 
                85                  90                  95      


Leu Ala Leu Ala Gly Ala Val Gln Arg Leu Glu Gly Ala Leu Trp Gly 
            100                 105                 110         


Leu Gln Ala Gln Ala Val Gln Thr Glu Gln Ala Val Ala Leu Leu Arg 
        115                 120                 125             


Asp Arg Thr Gly Gln Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr Gln 
    130                 135                 140                 


Leu Gln Val Glu Ser Asn Ser Ser Gln Leu Leu Leu Arg Arg His Ala 
145                 150                 155                 160 


Gly Leu Leu Asp Gly Leu Ala Arg Arg Val Gly Ile Leu Gly Glu Glu 
                165                 170                 175     


Leu Ala Asp Val Gly Gly Val Leu Arg Gly Leu Asn His Ser Leu Ser 
            180                 185                 190         


Tyr Asp Val Ala Leu His Arg Thr Arg Leu Gln Asp Leu Arg Val Leu 
        195                 200                 205             


Val Ser Asn Ala Ser Glu Asp Thr Arg Arg Leu Arg Leu Ala His Val 
    210                 215                 220                 


Gly Met Glu Leu Gln Leu Lys Gln Glu Leu Ala Met Leu Asn Ala Val 
225                 230                 235                 240 


Thr Glu Asp Leu Arg Leu Lys Asp Trp Glu His Ser Ile Ala Leu Arg 
                245                 250                 255     


Asn Ile Ser Leu Ala Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly 
            260                 265                 270         


Asp Glu Gly Lys Glu Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu 
        275                 280                 285             


Arg Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys 
    290                 295                 300                 


Gly Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly 
305                 310                 315                 320 


Phe Lys Gly Asp Arg Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp 
                325                 330                 335     


Arg Ala Gly Asp Ala Ser Lys Asp Ile Leu Leu Gly Pro Trp Asp Met 
            340                 345                 350         


Val Leu Ala Gln Gly 
        355         


<210>  8
<211>  1514
<212>  DNA
<213>  Homo sapiens

<400>  8
tttattttat acggactggc ggcgagagca gctgcagttc gcatctcagg cagtacctag     60

aggagctgcc ggtgcctcct cagaacatct cctgatcgct acccaggacc aggcaccaag    120

gacagggagt cccaggcgca caccccccat tctgggtccc ccaggcccag acccccactc    180

tgccacaggt tgcatcttga cctggtcctc ctgcagaagt ggcccctgtg gtcctgctct    240

gagactcgtc cctgggcgcc cctgcagccc ctttctatga ctccatctgg atttggctgg    300

ctgtggggac gcggtccgag gggcggcctg gctctcagcg tggtggcagc cagctctctg    360

gccaccatgg caaatgctga gatctgaggg gacaaggctc tacagcctca gccaggggca    420

ctcagctgtt gcagggtgtg atggagaaca aagctatgta cctacacacc gtcagcgact    480

gtgacaccag ctccatctgt gaggattcct ttgatggcag gagcctgtcc aagctgaacc    540

tgtgtgagga tgtgtccagg ccgcgcagct cccctgacga cctgaaggcc ctgactcgca    600

atgtgaaccg gctgaatgag agcttccggg acttgcagct gcggctgctg caggctccgc    660

tgcaagcgga cctgacggag caggtgtgga aggtgcagga cgcgctgcag aaccagtcag    720

actcgttgct ggcgctggcg ggcgcagtgc agcggctgga gggcgcgctg tgggggctgc    780

aggcgcaggc ggtgcagacc gagcaggcgg tggccctgct gcgggaccgc acgggccagc    840

agagcgacac ggcgcagctg gagctctacc agctgcaggt ggagagcaac agtagccagc    900

tgctgctgag gcgccacgcg ggcctgctgg acgggctggc gcgcagggtg ggcatcctgg    960

gcgaggagct ggccgacgtg ggcggcgtgc tgcgcggcct caaccacagc ctgtcctacg   1020

acgtggccct ccaccgcacg cggctgcagg acctgcgggt gctggtgagc aacgccagcg   1080

aggacacgcg ccgcctgcgc ctggcgcacg taggcatgga gctgcagctg aagcaggagc   1140

tggccatgct caacgcggtc accgaggacc tgcgcctcaa ggactgggag cactccatcg   1200

cactgcggaa catctccctc gcgaaagggc caccgggacc caaaggtgat cagggggatg   1260

aaggaaagga aggcaggcct ggcatccctg gattgcctgg acttcgaggt ctgcccgggg   1320

agagaggtac cccaggattg cccgggccca agggcgatga tgggaagctg ggggccacag   1380

gaccaatggg catgcgtggg ttcaaaggtg accgaggccc aaaaggagag aaaggagaga   1440

aaggagacag agctggggat gccagtaagg acattctgct ggggccgtgg gatatggtgt   1500

tggcacaggg ctag                                                     1514


<210>  9
<211>  2951
<212>  DNA
<213>  Homo sapiens

<400>  9
tttattttat acggactggc ggcgagagca gctgcagttc gcatctcagg cagtacctag     60

aggagctgcc ggtgcctcct cagaacatct cctgatcgct acccaggacc aggcaccaag    120

gacagggagt cccaggcgca caccccccat tctgggtccc ccaggcccag acccccactc    180

tgccacaggt tgcatcttga cctggtcctc ctgcagaagt ggcccctgtg gtcctgctct    240

gagactcgtc cctgggcgcc cctgcagccc ctttctatga ctccatctgg atttggctgg    300

ctgtggggac gcggtccgag gggcggcctg gctctcagcg tggtggcagc cagctctctg    360

gccaccatgg caaatgctga gatctgaggg gacaaggctc tacagcctca gccaggggca    420

ctcagctgtt gcagggtgtg atggagaaca aagctatgta cctacacacc gtcagcgact    480

gtgacaccag ctccatctgt gaggattcct ttgatggcag gagcctgtcc aagctgaacc    540

tgtgtgagga tggtccatgt cacaaacggc gggcaagcat ctgctgtacc cagctggggt    600

ccctgtcggc cctgaagcat gctgtcctgg ggctctacct gctggtcttc ctgattcttg    660

tgggcatctt catcttagca gggccaccgg gacccaaagg tgatcagggg gatgaaggaa    720

aggaaggcag gcctggcatc cctggattgc ctggacttcg aggtctgccc ggggagagag    780

gtaccccagg attgcccggg cccaagggcg atgatgggaa gctgggggcc acaggaccaa    840

tgggcatgcg tgggttcaaa ggtgaccgag gcccaaaagg agagaaagga gagaaaggag    900

acagagctgg ggatgccagt ggcgtggagg ccccgatgat gatccgcctg gtgaatggct    960

caggtccgca cgagggccgc gtggaagtgt accacgaccg gcgttggggc accgtgtgtg   1020

acgacggctg ggacaagaag gacggagacg tggtgtgccg catgctcggc ttccgcggtg   1080

tggaggaggt gtaccgcaca gctcgattcg ggcaaggcac tgggaggatc tggatggatg   1140

acgttgcctg caagggcaca gaggaaacca tcttccgctg cagcttctcc aaatgggggg   1200

tgacaaactg tggacatgcc gaagatgcca gcgtgacatg caacagacac tgaaagtggg   1260

cagagcccaa gttcggggtc ctgcacagag cacccttcct gcatccctgg ggtggggcac   1320

agctcggggc caccctgacc atgcctcgac cacaccccgt ccagcattct cagtcctcac   1380

acctgcatcc caggaccgtg ggggccggtc gtcatttccc tcttgaacat gtgctccgaa   1440

gtataactct gggacctact gcccgtctct ctcttccacc aggttcctgc atgaggagcc   1500

ctgatcaact ggatcaccac tttgcccagc ctctgaacac catgcaccag gcctcaatat   1560

cccagttccc tttggccttt tagttacagg tgaatgctga gaatgtgtca gagacaagtg   1620

cagcagcagc gatggttggt agtatagatc atttactctt cagacaattc ccaaacctcc   1680

attagtccaa gagtttctac atcttcctcc ccagcaagag gcaacgtcaa gtgatgaatt   1740

tccccccttt actctgcctc tgctccccat ttgctagttt gaggaagtga catagaggag   1800

aagccagctg taggggcaag agggaaatgc aagtcacctg caggaatcca gctagatttg   1860

gagaagggaa tgaaactaac attgaatgac taccatggca cgctaaatag tatcttgggt   1920

gccaaattca tgtatccact tagctgcatt ggtccagggc atgtcagtct ggatacagcc   1980

ttacctccag gtagcactta actggtccat tcacctagac tgcaagtaag aagacaaaat   2040

gactgagacc gtgtgcccac ctgaacttat tgtctttact tggcctgagc taaaagcttg   2100

ggtgcaggac ctgtgtaact agaaagttgc ctacttcaga acctccaggg cgtgagtgca   2160

aggtcaaaca tgactggctt ccaggccgac catcaatgta ggaggagagc tgatgtggag   2220

ggtgacatgg gggctgccca tgttaaacct gagtccagtg ctctggcatt gggcagtcac   2280

ggttaaagcc aagtcatgtg tgtctcagct gtttggaggt gatgattttg catcttccaa   2340

gcctcttcag gtgtgaatct gtggtcagga aaacacaagt cctaatggaa cccttagggg   2400

ggaaggaaat gaagattccc tataacctct gggggtgggg agtaggaata aggggccttg   2460

ggcctccata aatctgcaat ctgcaccctc ctcctagaga cagggagatc gtgttctgct   2520

ttttacatga ggagcagaac tgggccatac acatgttcaa gaactagggg agctacctgg   2580

tagcaagtga gtgcagaccc acctcacctt gggggaatct caaactcata ggcctcagat   2640

acacgatcac ctgtcatatc aggtgagcac tggcctgctt ggggagagac ctgggcccct   2700

ccaggtgtag gaacagcaac actcctggct gacaactaag ccaatatggc cctaggtcat   2760

tcttgcttcc aatatgcttg ccactcctta aatgtcctaa tgatgagaaa ctctctttct   2820

gaccaattgc tatgtttaca taacacgcat gtactcatgc atcccttgcc agagcccata   2880

tatgtatgca tatataaaca tagcactttt tactacatag ctcagcacat tgcaaggttt   2940

gcatttaagt t                                                        2951


<210>  10
<211>  3980
<212>  DNA
<213>  Homo sapiens

<400>  10
tttattttat acggactggc ggcgagagca gctgcagttc gcatctcagg cagtacctag     60

aggagctgcc ggtgcctcct cagaacatct cctgatcgct acccaggacc aggcaccaag    120

gacagggagt cccaggcgca caccccccat tctgggtccc ccaggcccag acccccactc    180

tgccacaggt tgcatcttga cctggtcctc ctgcagaagt ggcccctgtg gtcctgctct    240

gagactcgtc cctgggcgcc cctgcagccc ctttctatga ctccatctgg atttggctgg    300

ctgtggggac gcggtccgag gggcggcctg gctctcagcg tggtggcagc cagctctctg    360

gccaccatgg caaatgctga gatctgaggg gacaaggctc tacagcctca gccaggggca    420

ctcagctgtt gcagggtgtg atggagaaca aagctatgta cctacacacc gtcagcgact    480

gtgacaccag ctccatctgt gaggattcct ttgatggcag gagcctgtcc aagctgaacc    540

tgtgtgagga tggtccatgt cacaaacggc gggcaagcat ctgctgtacc cagctggggt    600

ccctgtcggc cctgaagcat gctgtcctgg ggctctacct gctggtcttc ctgattcttg    660

tgggcatctt catcttagca gtgtccaggc cgcgcagctc ccctgacgac ctgaaggccc    720

tgactcgcaa tgtgaaccgg ctgaatgaga gcttccggga cttgcagctg cggctgctgc    780

aggctccgct gcaagcggac ctgacggagc aggtgtggaa ggtgcaggac gcgctgcaga    840

accagtcaga ctcgttgctg gcgctggcgg gcgcagtgca gcggctggag ggcgcgctgt    900

gggggctgca ggcgcaggcg gtgcagaccg agcaggcggt ggccctgctg cgggaccgca    960

cgggccagca gagcgacacg gcgcagctgg agctctacca gctgcaggtg gagagcaaca   1020

gtagccagct gctgctgagg cgccacgcgg gcctgctgga cgggctggcg cgcagggtgg   1080

gcatcctggg cgaggagctg gccgacgtgg gcggcgtgct gcgcggcctc aaccacagcc   1140

tgtcctacga cgtggccctc caccgcacgc ggctgcagga cctgcgggtg ctggtgagca   1200

acgccagcga ggacacgcgc cgcctgcgcc tggcgcacgt aggcatggag ctgcagctga   1260

agcaggagct ggccatgctc aacgcggtca ccgaggacct gcgcctcaag gactgggagc   1320

actccatcgc actgcggaac atctccctcg cgaaagggcc accgggaccc aaaggtgatc   1380

agggggatga aggaaaggaa ggcaggcctg gcatccctgg attgcctgga cttcgaggtc   1440

tgcccgggga gagaggtacc ccaggattgc ccgggcccaa gggcgatgat gggaagctgg   1500

gggccacagg accaatgggc atgcgtgggt tcaaaggtga ccgaggccca aaaggagaga   1560

aaggagagaa aggagacaga gctggggatg ccagtggcgt ggaggccccg atgatgatcc   1620

gcctggtgaa tggctcaggt ccgcacgagg gccgcgtgga agtgtaccac gaccggcgtt   1680

ggggcaccgt gtgtgacgac ggctgggaca agaaggacgg agacgtggtg tgccgcatgc   1740

tcggcttccg cggtgtggag gaggtgtacc gcacagctcg attcgggcaa ggcactggga   1800

ggatctggat ggatgacgtt gcctgcaagg gcacagagga aaccatcttc cgctgcagct   1860

tctccaaatg gggggtgaca aactgtggac atgccgaaga tgccagcgtg acatgcaaca   1920

gacactgaaa gtgggcagag cccaagttcg gggtcctgca cagagcaccc ttcctgcatc   1980

cctggggtgg ggcacagctc ggggccaccc tgaccatgcc tcgaccacac cccgtccagc   2040

attctcagtc ctcacacctg catcccagga ccgtgggggc cggtcgtcat ttccctcttg   2100

aacatgtgct ccgaagtata actctgggac ctactgcccg tctctctctt ccaccaggtt   2160

cctgcatgag gagccctgat caactggatc accactttgc ccagcctctg aacaccatgc   2220

accaggcctc aatatcccag ttccctttgg ccttttagtt acaggtgaat gctgagaatg   2280

tgtcagagac aagtgcagca gcagcgatgg ttggtagtat agatcattta ctcttcagac   2340

aattcccaaa cctccattag tccaagagtt tctacatctt cctccccagc aagaggcaac   2400

gtcaagtgat gaatttcccc cctttactct gcctctgctc cccatttgct agtttgagga   2460

agtgacatag aggagaagcc agctgtaggg gcaagaggga aatgcaagtc acctgcagga   2520

atccagctag atttggagaa gggaatgaaa ctaacattga atgactacca tggcacgcta   2580

aatagtatct tgggtgccaa attcatgtat ccacttagct gcattggtcc agggcatgtc   2640

agtctggata cagccttacc tccaggtagc acttaactgg tccattcacc tagactgcaa   2700

gtaagaagac aaaatgactg agaccgtgtg cccacctgaa cttattgtct ttacttggcc   2760

tgagctaaaa gcttgggtgc aggacctgtg taactagaaa gttgcctact tcagaacctc   2820

cagggcgtga gtgcaaggtc aaacatgact ggcttccagg ccgaccatca atgtaggagg   2880

agagctgatg tggagggtga catgggggct gcccatgtta aacctgagtc cagtgctctg   2940

gcattgggca gtcacggtta aagccaagtc atgtgtgtct cagctgtttg gaggtgatga   3000

ttttgcatct tccaagcctc ttcaggtgtg aatctgtggt caggaaaaca caagtcctaa   3060

tggaaccctt aggggggaag gaaatgaaga ttccctataa cctctggggg tggggagtag   3120

gaataagggg ccttgggcct ccataaatct gcaatctgca ccctcctcct agagacaggg   3180

agatcgtgtt ctgcttttta catgaggagc agaactgggc catacacatg ttcaagaact   3240

aggggagcta cctggtagca agtgagtgca gacccacctc accttggggg aatctcaaac   3300

tcataggcct cagatacacg atcacctgtc atatcaggtg agcactggcc tgcttgggga   3360

gagacctggg cccctccagg tgtaggaaca gcaacactcc tggctgacaa ctaagccaat   3420

atggccctag gtcattcttg cttccaatat gcttgccact ccttaaatgt cctaatgatg   3480

agaaactctc tttctgacca attgctatgt ttacataaca cgcatgtact catgcatccc   3540

ttgccagagc ccatatatgt atgcatatat aaacatagca ctttttacta catagctcag   3600

cacattgcaa ggtttgcatt taagttaaaa aaaaaaaaaa aaaaaaacta aaggtgaaag   3660

atgccacatt gaacaaacta aattcccaac ccggttctgg caaagaatcc agttatccct   3720

tccatgaaga cgcacataac tctcttactt ggtctttcca ttagggacaa cataagtctt   3780

gttttacatc aaataaaaac aatgttaaaa agtgtgtgaa ccttaaaaat ggaagtctac   3840

tagtttacat acctacttca gaggacatgg aaatgaccat gggcctgcat ttcagggacc   3900

aaagcaaatt aggcctggcc taaaatacat cagacctttt gtaagaaaga atttcaataa   3960

agcaaaaaac atgtcacaag                                               3980


<210>  11
<211>  1968
<212>  DNA
<213>  Homo sapiens

<400>  11
tagaggagct gccggtgcct cctcagaaca tctcctgatc gctacccagg accaggcacc     60

aaggacaggg agtcccaggc gcacaccccc cattctgggt cccccaggcc cagaccccca    120

ctctgccaca ggttgcatct tgacctggtc ctcctgcaga agtggcccct gtggtcctgc    180

tctgagactc gtccctgggc gcccctgcag cccctttcta tgactccatc tggatttggc    240

tggctgtggg gacgcggtcc gaggggcggc ctggctctca gcgtggtggc agccagctct    300

ctggccacca tggcaaatgc tgagatctga ggggacaagg ctctacagcc tcagccaggg    360

gcactcagct gttgcagggt gtgatggaga acaaagctat gtacctacac accgtcagcg    420

actgtgacac cagctccatc tgtgaggatt cctttgatgg caggagcctg tccaagctga    480

acctgtgtga ggatggtcca tgtcacaaac ggcgggcaag catctgctgt acccagctgg    540

ggtccctgtc ggccctgaag catgctgtcc tggggctcta cctgctggtc ttcctgattc    600

ttgtgggcat cttcatctta gcagtgtcca ggccgcgcag ctcccctgac gacctgaagg    660

ccctgactcg caatgtgaac cggctgaatg agagcttccg ggacttgcag ctgcggctgc    720

tgcaggctcc gctgcaagcg gacctgacgg agcaggtgtg gaaggtgcag gacgcgctgc    780

agaaccagtc agactcgttg ctggcgctgg cgggcgcagt gcagcggctg gagggcgcgc    840

tatgggggct gcaggcgcag gcggtgcaga ccgagcaggc ggtggccctg ctgcgggacc    900

gcacgggcca gcagagcgac acggcgcagc tggagctcta ccagctgcag gtggagagca    960

acagtagcca gctgctgctg aggcgccacg cgggcctgct ggacgggctg gcgcgcaggg   1020

tgggcatcct gggcgaggag ctggccgacg tgggcggcgt gctgcgcggc ctcaaccaca   1080

gcctgtccta cgacgtggcc ctccaccgca cgcggctgca ggacctgcgg gtgctggtga   1140

gcaacgccag cgaggacacg cgccgcctgc gcctggcgca cgtaggcatg gagctgcagc   1200

tgaagcagga gctggccatg ctcaacgcgg tcaccgagga cctgcgcctc aaggactggg   1260

agcactccat cgcactgcgg aacatctccc tcgcgaaagg gccaccggga cccaaaggtg   1320

atcaggggga tgaaggaaag gaaggcaggc ctggcatccc tggattgcct ggacttcgag   1380

gtctgcccgg ggagagaggt accccaggat tgcccgggcc caagggcgat gatgggaagc   1440

tgggggccac aggaccaatg ggcatgcgtg ggttcaaagg tgaccgaggc ccaaaaggag   1500

agaaaggaga gaaaggagac agagctgggg atgccagtaa ggacattctg ctggggccgt   1560

gggatatggt gttggcacag ggctagctgt cccccgagca gccccataag tttggaggtt   1620

cagaggctgg agccatggct ggggctcaag tgtcaaagga ggctccctac cttttttagg   1680

gctctgctgg tctagcaaga gatgctgata gaccccaggg gcactggcca catttctaga   1740

ggtgtcataa acctggcggt tgtgtgcatg gatctggagg cttcccccgg tcactcgcta   1800

gcccagctgg tataatctct gtgcctcagt gttctcatct ataaaatagg gataacagga   1860

gtctttacct tataaggtca ttgtgaaaat tgaatgagtt aatctgtgta aagtgcttat   1920

gatcatgctg gacacctggt gaggaaaaaa aaaaaaaaaa aaaaaaaa                1968


<210>  12
<211>  848
<212>  DNA
<213>  Homo sapiens

<400>  12
tttatacgga ctggcggcga gagcagctgc agttcgcatc tcaggcagta cctagaggag     60

ctgcagctga agcaggagct ggccatgctc aacgcggtca ccgaggacct gcgcctcaag    120

gactgggagc actccatcgc actgcggaac atctccctcg cgaaagggcc accgggaccc    180

aaaggtgatc agggggatga aggaaaggaa ggcaggcctg gcatccctgg attgcctgga    240

cttcgaggtc tgcccgggga gagaggtacc ccaggattgc ccgggcccaa gggcgatgat    300

gggaagctgg gggccacagg accaatgggc atgcgtgggt tcaaaggtga ccgaggccca    360

aaaggagaga aaggagagaa aggagacaga gctggggatg ccagtggcgt ggaggccccg    420

atgatgatcc gcctggtgaa tggctcaggt ccgcacgagg gccgcgtgga agtgtaccac    480

gaccggcgtt ggggcaccgt gtgtgacgac ggctgggaca agaaggacgg agacgtggtg    540

tgccgcatgc tcggcttccg cggtgtggag gaggtgtacc gcacagctcg attcgggcaa    600

ggcactggga ggatctggat ggatgacgtt gcctgcaagg gcacagagga aaccatcttc    660

cgctgcagct tctccaaatg gggggtgaca aactgtggac atgccgaaga tgccagcgtg    720

acatgcaaca gacactgaaa gtgggcagag cccaagttcg gggtcctgca cagagcaccc    780

ttcctgcatc cctggggtgg ggcacagctc ggggccaccc tgaccatgcc tcgaccacac    840

cccgtcca                                                             848


<210>  13
<211>  567
<212>  DNA
<213>  Homo sapiens

<400>  13
actcgcaatg tgaaccggct gaatgagagc ttccgggact tgcagctgcg gctgctgcag     60

gctccgctgc aagcggacct gacggagcag gtgtggaagg tgcaggacgc gctgcagaac    120

cagtcagact cgttgctggc gctggcgggc gcagtgcagc ggctggaggg cgcgctgtgg    180

ggcctgcgcc tggcgcacgt aggcatggag ctgcagctga agcaggagct ggccatgctc    240

aacgcggtca ccgaggacct gcgcctcaag gactgggagc actccatcgc actgcggaac    300

atctccctcg cgaaagggcc accgggaccc aaaggtgatc agggggatga aggaaaggaa    360

ggcaggcctg gcatccctgg attgcctgga cttcgaggtc tgcccgggga gagaggtacc    420

ccaggattgc ccgggcccaa gggcgatgat gggaagctgg gggccacagg accaatgggc    480

atgcgtgggt tcaaaggtga ccgaggccca aaaggagaga aaggagagaa aggagacaga    540

gctggggatg ccagtggcgt ggaggcc                                        567


<210>  14
<211>  1074
<212>  DNA
<213>  Homo sapiens

<400>  14
atggagaaca aagctatgta cctacacacc gtcagcgact gtgacaccag ctccatctgt     60

gaggattcct ttgatggcag gagcctgtcc aagctgaacc tgtgtgagga tgtgtccagg    120

ccgcgcagct cccctgacga cctgaaggcc ctgactcgca atgtgaaccg gctgaatgag    180

agcttccggg acttgcagct gcggctgctg caggctccgc tgcaagcgga cctgacggag    240

caggtgtgga aggtgcagga cgcgctgcag aaccagtcag actcgttgct ggcgctggcg    300

ggcgcagtgc agcggctgga gggcgcgctg tgggggctgc aggcgcaggc ggtgcagacc    360

gagcaggcgg tggccctgct gcgggaccgc acgggccagc agagcgacac ggcgcagctg    420

gagctctacc agctgcaggt ggagagcaac agtagccagc tgctgctgag gcgccacgcg    480

ggcctgctgg acgggctggc gcgcagggtg ggcatcctgg gcgaggagct ggccgacgtg    540

ggcggcgtgc tgcgcggcct caaccacagc ctgtcctacg acgtggccct ccaccgcacg    600

cggctgcagg acctgcgggt gctggtgagc aacgccagcg aggacacgcg ccgcctgcgc    660

ctggcgcacg taggcatgga gctgcagctg aagcaggagc tggccatgct caacgcggtc    720

accgaggacc tgcgcctcaa ggactgggag cactccatcg cactgcggaa catctccctc    780

gcgaaagggc caccgggacc caaaggtgat cagggggatg aaggaaagga aggcaggcct    840

ggcatccctg gattgcctgg acttcgaggt ctgcccgggg agagaggtac cccaggattg    900

cccgggccca agggcgatga tgggaagctg ggggccacag gaccaatggg catgcgtggg    960

ttcaaaggtg accgaggccc aaaaggagag aaaggagaga aaggagacag agctggggat   1020

gccagtaagg acattctgct ggggccgtgg gatatggtgt tggcacaggg ctag         1074


<210>  15
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  15

Lys Asp Ile Leu Leu Gly Pro Trp Asp Met Val Leu Ala Gln Gly 
1               5                   10                  15  


