
                                SEQUENCE LISTING

<110> THE J. DAVID GLADSTONE INSTITUTES
      SRIVASTAVA, DEEPAK
      Ieda, Masaki

<120> Methods for Generating Cardiomyocytes
  

<130> GLAD-391WO

<150> US 61/364,295       
<151> 2010-07-14  

<150> US 61/328,988       
<151> 2010-04-28  

<160> 48

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 1
Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg
 1               5                  10      


<210> 2
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 2
Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg
 1               5                  10          


<210> 3
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 3
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu
 1               5                  10                  15      
Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu
            20                  25          


<210> 4
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 4
Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala
 1               5                  10                  15      
Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu
            20                  25                  30          
Ala
    


<210> 5
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 5
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys
 1               5                  10                  15      


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 6
Arg Lys Lys Arg Arg Gln Arg Arg Arg
 1               5                  


<210> 7
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 7
Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala
 1               5                  10      


<210> 8
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 8
Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg
 1               5                  10      


<210> 9
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 9
Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg
 1               5                  10      


<210> 10
<211> 10
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<220> 
<221> misc_difference
<222> 3, 4
<223> n =a or t

<400> 10
ctnnaaatag                                                        10

<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic primer

<400> 11
atgacagaca gatccctcct                                             20

<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic primer

<400> 12
aagtcgtgct gcttcatgtg                                             20

<210> 13
<211> 442
<212> PRT
<213> Homo sapiens

<400> 13
Met Tyr Gln Ser Leu Ala Met Ala Ala Asn His Gly Pro Pro Pro Gly
 1               5                  10                  15      
Ala Tyr Glu Ala Gly Gly Pro Gly Ala Phe Met His Gly Ala Gly Ala
            20                  25                  30          
Ala Ser Ser Pro Val Tyr Val Pro Thr Pro Arg Val Pro Ser Ser Val
        35                  40                  45              
Leu Gly Leu Ser Tyr Leu Gln Gly Gly Gly Ala Gly Ser Ala Ser Gly
    50                  55                  60                  
Gly Ala Ser Gly Gly Ser Ser Gly Gly Ala Ala Ser Gly Ala Gly Pro
65                  70                  75                  80  
Gly Thr Gln Gln Gly Ser Pro Gly Trp Ser Gln Ala Gly Ala Asp Gly
                85                  90                  95      
Ala Ala Tyr Thr Pro Pro Pro Val Ser Pro Arg Phe Ser Phe Pro Gly
            100                 105                 110         
Thr Thr Gly Ser Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Arg Glu
        115                 120                 125             
Ala Ala Ala Tyr Ser Ser Gly Gly Gly Ala Ala Gly Ala Gly Leu Ala
    130                 135                 140                 
Gly Arg Glu Gln Tyr Gly Arg Ala Gly Phe Ala Gly Ser Tyr Ser Ser
145                 150                 155                 160 
Pro Tyr Pro Ala Tyr Met Ala Asp Val Gly Ala Ser Trp Ala Ala Ala
                165                 170                 175     
Ala Ala Ala Ser Ala Gly Pro Phe Asp Ser Pro Val Leu His Ser Leu
            180                 185                 190         
Pro Gly Arg Ala Asn Pro Ala Ala Arg His Pro Asn Leu Asp Met Phe
        195                 200                 205             
Asp Asp Phe Ser Glu Gly Arg Glu Cys Val Asn Cys Gly Ala Met Ser
    210                 215                 220                 
Thr Pro Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala
225                 230                 235                 240 
Cys Gly Leu Tyr His Lys Met Asn Gly Ile Asn Arg Pro Leu Ile Lys
                245                 250                 255     
Pro Gln Arg Arg Leu Ser Ala Ser Arg Arg Val Gly Leu Ser Cys Ala
            260                 265                 270         
Asn Cys Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly
        275                 280                 285             
Glu Pro Val Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val
    290                 295                 300                 
Pro Arg Pro Leu Ala Met Arg Lys Glu Gly Ile Gln Thr Arg Lys Arg
305                 310                 315                 320 
Lys Pro Lys Asn Leu Asn Lys Ser Lys Thr Pro Ala Ala Pro Ser Gly
                325                 330                 335     
Ser Glu Ser Leu Pro Pro Ala Ser Gly Ala Ser Ser Asn Ser Ser Asn
            340                 345                 350         
Ala Thr Thr Ser Ser Ser Glu Glu Met Arg Pro Ile Lys Thr Glu Pro
        355                 360                 365             
Gly Leu Ser Ser His Tyr Gly His Ser Ser Ser Val Ser Gln Thr Phe
    370                 375                 380                 
Ser Val Ser Ala Met Ser Gly His Gly Pro Ser Ile His Pro Val Leu
385                 390                 395                 400 
Ser Ala Leu Lys Leu Ser Pro Gln Gly Tyr Ala Ser Pro Val Ser Gln
                405                 410                 415     
Ser Pro Gln Thr Ser Ser Lys Gln Asp Ser Trp Asn Ser Leu Val Leu
            420                 425                 430         
Ala Asp Ser His Gly Asp Ile Ile Thr Ala
        435                 440         


<210> 14
<211> 1329
<212> DNA
<213> Homo sapiens

<400> 14
atgtatcaga gcttggccat ggccgccaac cacgggccgc cccccggtgc ctacgaggcg 60
ggcggccccg gcgccttcat gcacggcgcg ggcgccgcgt cctcgccagt ctacgtgccc 120
acaccgcggg tgccctcctc cgtgctgggc ctgtcctacc tccagggcgg aggcgcgggc 180
tctgcgtccg gaggcgcctc gggcggcagc tccggtgggg ccgcgtctgg tgcggggccc 240
gggacccagc agggcagccc gggatggagc caggcgggag ccgacggagc cgcttacacc 300
ccgccgccgg tgtcgccgcg cttctccttc ccggggacca ccgggtccct ggcggccgcc 360
gccgccgctg ccgcggcccg ggaagctgcg gcctacagca gtggcggcgg agcggcgggt 420
gcgggcctgg cgggccgcga gcagtacggg cgcgccggct tcgcgggctc ctactccagc 480
ccctacccgg cttacatggc cgacgtgggc gcgtcctggg ccgcagccgc cgccgcctcc 540
gccggcccct tcgacagccc ggtcctgcac agcctgcccg gccgggccaa cccggccgcc 600
cgacacccca atctcgatat gtttgacgac ttctcagaag gcagagagtg tgtcaactgt 660
ggggctatgt ccaccccgct ctggaggcga gatgggacgg gtcactatct gtgcaacgcc 720
tgcggcctct accacaagat gaacggcatc aaccggccgc tcatcaagcc tcagcgccgg 780
ctgtccgcct cccgccgagt gggcctctcc tgtgccaact gccagaccac caccaccacg 840
ctgtggcgcc gcaatgcgga gggcgagcct gtgtgcaatg cctgcggcct ctacatgaag 900
ctccacgggg tccccaggcc tcttgcaatg cggaaagagg ggatccaaac cagaaaacgg 960
aagcccaaga acctgaataa atctaagaca ccagcagctc cttcaggcag tgagagcctt 1020
cctcccgcca gcggtgcttc cagcaactcc agcaacgcca ccaccagcag cagcgaggag 1080
atgcgtccca tcaagacgga gcctggcctg tcatctcact acgggcacag cagctccgtg 1140
tcccagacgt tctcagtcag tgcgatgtct ggccatgggc cctccatcca ccctgtcctc 1200
tcggccctga agctctcccc acaaggctat gcgtctcccg tcagccagtc tccacagacc 1260
agctccaagc aggactcttg gaacagcctg gtcttggccg acagtcacgg ggacataatc 1320
actgcgtaa                                                         1329

<210> 15
<211> 463
<212> PRT
<213> Homo sapiens

<400> 15
Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn
 1               5                  10                  15      
Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala
            20                  25                  30          
Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe
        35                  40                  45              
Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys
    50                  55                  60                  
Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr
65                  70                  75                  80  
Asn Ser Asp Ile Val Glu Ala Leu Asn Lys Lys Glu Asn Lys Gly Cys
                85                  90                  95      
Glu Ser Pro Asp Pro Asp Ser Ser Tyr Ala Leu Thr Pro Arg Thr Glu
            100                 105                 110         
Glu Lys Tyr Lys Lys Ile Asn Glu Glu Phe Asp Asn Met Ile Lys Ser
        115                 120                 125             
His Lys Ile Pro Ala Val Pro Pro Pro Asn Phe Glu Met Pro Val Ser
    130                 135                 140                 
Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro Val Ser
145                 150                 155                 160 
Ser Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser Leu Gln
                165                 170                 175     
Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser Ala Gly
            180                 185                 190         
Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala Gly Thr
        195                 200                 205             
Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly Leu Leu
    210                 215                 220                 
Val Ser Pro Gly Asn Leu Asn Lys Asn Met Gln Ala Lys Ser Pro Pro
225                 230                 235                 240 
Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg Val Leu
                245                 250                 255     
Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Asn Gln Arg Ile
            260                 265                 270         
Asn Asn Ser Gln Ser Ala Gln Ser Leu Ala Thr Pro Val Val Ser Val
        275                 280                 285             
Ala Thr Pro Thr Leu Pro Gly Gln Gly Met Gly Gly Tyr Pro Ser Ala
    290                 295                 300                 
Ile Ser Thr Thr Tyr Gly Thr Glu Tyr Ser Leu Ser Ser Ala Asp Leu
305                 310                 315                 320 
Ser Ser Leu Ser Gly Phe Asn Thr Ala Ser Ala Leu His Leu Gly Ser
                325                 330                 335     
Val Thr Gly Trp Gln Gln Gln His Leu His Asn Met Pro Pro Ser Ala
            340                 345                 350         
Leu Ser Gln Leu Gly Ala Cys Thr Ser Thr His Leu Ser Gln Ser Ser
        355                 360                 365             
Asn Leu Ser Leu Pro Ser Thr Gln Ser Leu Asn Ile Lys Ser Glu Pro
    370                 375                 380                 
Val Ser Pro Pro Arg Asp Arg Thr Thr Thr Pro Ser Arg Tyr Pro Gln
385                 390                 395                 400 
His Thr Arg His Glu Ala Gly Arg Ser Pro Val Asp Ser Leu Ser Ser
                405                 410                 415     
Cys Ser Ser Ser Tyr Asp Gly Ser Asp Arg Glu Asp His Arg Asn Glu
            420                 425                 430         
Phe His Ser Pro Ile Gly Leu Thr Arg Pro Ser Pro Asp Glu Arg Glu
        435                 440                 445             
Ser Pro Ser Val Lys Arg Met Arg Leu Ser Glu Gly Trp Ala Thr
    450                 455                 460             


<210> 16
<211> 1392
<212> DNA
<213> Homo sapiens

<400> 16
atggggagaa aaaagattca gattacgagg attatggatg aacgtaacag acaggtgaca 60
tttacaaaga ggaaatttgg gttgatgaag aaggcttatg agctgagcgt gctgtgtgac 120
tgtgagattg cgctgatcat cttcaacagc accaacaagc tgttccagta tgccagcacc 180
gacatggaca aagtgcttct caagtacacg gagtacaacg agccgcatga gagccggaca 240
aactcagaca tcgtggaggc attgaacaag aaagaaaaca aaggctgtga aagccccgat 300
cccgactcct cttatgcact caccccacgc actgaagaaa aatacaaaaa aattaatgaa 360
gaatttgata atatgatcaa gagtcataaa attcctgctg ttccacctcc caacttcgag 420
atgccagtct ccatcccagt gtccagccac aacagtttgg tgtacagcaa ccctgtcagc 480
tcactgggaa accccaacct attgccactg gctcaccctt ctctgcagag gaatagtatg 540
tctcctggtg taacacatcg acctccaagt gcaggtaaca caggtggtct gatgggtgga 600
gacctcacgt ctggtgcagg caccagtgca gggaacgggt atggcaatcc ccgaaactca 660
ccaggtctgc tggtctcacc tggtaacttg aacaagaata tgcaagcaaa atctcctccc 720
ccaatgaatt taggaatgaa taaccgtaaa ccagatctcc gagttcttat tccaccaggc 780
agcaagaata cgatgccatc agtgaatcaa aggataaata actcccagtc ggctcagtca 840
ttggctaccc cagtggtttc cgtagcaact cctactttac caggacaagg aatgggagga 900
tatccatcag ccatttcaac aacatatggt accgagtact ctctgagtag tgcagacctg 960
tcatctctgt ctgggtttaa caccgccagc gctcttcacc ttggttcagt aactggctgg 1020
caacagcaac acctacataa catgccacca tctgccctca gtcagttggg agcttgcact 1080
agcactcatt tatctcagag ttcaaatctc tccctgcctt ctactcaaag cctcaacatc 1140
aagtcagaac ctgtttctcc tcctagagac cgtaccacca ccccttcgag atacccacaa 1200
cacacgcgcc acgaggcggg gagatctcct gttgacagct tgagcagctg tagcagttcg 1260
tacgacggga gcgaccgaga ggatcaccgg aacgaattcc actcccccat tggactcacc 1320
agaccttcgc cggacgaaag ggaaagtccc tcagtcaagc gcatgcgact ttctgaagga 1380
tgggcaacat ga                                                     1392

<210> 17
<211> 473
<212> PRT
<213> Homo sapiens

<400> 17
Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn
 1               5                  10                  15      
Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala
            20                  25                  30          
Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe
        35                  40                  45              
Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys
    50                  55                  60                  
Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr
65                  70                  75                  80  
Asn Ser Asp Ile Val Glu Thr Leu Arg Lys Lys Gly Leu Asn Gly Cys
                85                  90                  95      
Asp Ser Pro Asp Pro Asp Ala Asp Asp Ser Val Gly His Ser Pro Glu
            100                 105                 110         
Ser Glu Asp Lys Tyr Arg Lys Ile Asn Glu Asp Ile Asp Leu Met Ile
        115                 120                 125             
Ser Arg Gln Arg Leu Cys Ala Val Pro Pro Pro Asn Phe Glu Met Pro
    130                 135                 140                 
Val Ser Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro
145                 150                 155                 160 
Val Ser Ser Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser
                165                 170                 175     
Leu Gln Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser
            180                 185                 190         
Ala Gly Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala
        195                 200                 205             
Gly Thr Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly
    210                 215                 220                 
Leu Leu Val Ser Pro Gly Asn Leu Asn Lys Asn Met Gln Ala Lys Ser
225                 230                 235                 240 
Pro Pro Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg
                245                 250                 255     
Val Leu Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Ser Glu
            260                 265                 270         
Asp Val Asp Leu Leu Leu Asn Gln Arg Ile Asn Asn Ser Gln Ser Ala
        275                 280                 285             
Gln Ser Leu Ala Thr Pro Val Val Ser Val Ala Thr Pro Thr Leu Pro
    290                 295                 300                 
Gly Gln Gly Met Gly Gly Tyr Pro Ser Ala Ile Ser Thr Thr Tyr Gly
305                 310                 315                 320 
Thr Glu Tyr Ser Leu Ser Ser Ala Asp Leu Ser Ser Leu Ser Gly Phe
                325                 330                 335     
Asn Thr Ala Ser Ala Leu His Leu Gly Ser Val Thr Gly Trp Gln Gln
            340                 345                 350         
Gln His Leu His Asn Met Pro Pro Ser Ala Leu Ser Gln Leu Gly Ala
        355                 360                 365             
Cys Thr Ser Thr His Leu Ser Gln Ser Ser Asn Leu Ser Leu Pro Ser
    370                 375                 380                 
Thr Gln Ser Leu Asn Ile Lys Ser Glu Pro Val Ser Pro Pro Arg Asp
385                 390                 395                 400 
Arg Thr Thr Thr Pro Ser Arg Tyr Pro Gln His Thr Arg His Glu Ala
                405                 410                 415     
Gly Arg Ser Pro Val Asp Ser Leu Ser Ser Cys Ser Ser Ser Tyr Asp
            420                 425                 430         
Gly Ser Asp Arg Glu Asp His Arg Asn Glu Phe His Ser Pro Ile Gly
        435                 440                 445             
Leu Thr Arg Pro Ser Pro Asp Glu Arg Glu Ser Pro Ser Val Lys Arg
    450                 455                 460                 
Met Arg Leu Ser Glu Gly Trp Ala Thr
465                 470             


<210> 18
<211> 1422
<212> DNA
<213> Homo sapiens

<400> 18
atggggagaa aaaagattca gattacgagg attatggatg aacgtaacag acaggtgaca 60
tttacaaaga ggaaatttgg gttgatgaag aaggcttatg agctgagcgt gctgtgtgac 120
tgtgagattg cgctgatcat cttcaacagc accaacaagc tgttccagta tgccagcacc 180
gacatggaca aagtgcttct caagtacacg gagtacaacg agccgcatga gagccggaca 240
aactcagaca tcgtggagac gttgagaaag aagggcctta atggctgtga cagcccagac 300
cccgatgcgg acgattccgt aggtcacagc cctgagtctg aggacaagta caggaaaatt 360
aacgaagata ttgatctaat gatcagcagg caaagattgt gtgctgttcc acctcccaac 420
ttcgagatgc cagtctccat cccagtgtcc agccacaaca gtttggtgta cagcaaccct 480
gtcagctcac tgggaaaccc caacctattg ccactggctc acccttctct gcagaggaat 540
agtatgtctc ctggtgtaac acatcgacct ccaagtgcag gtaacacagg tggtctgatg 600
ggtggagacc tcacgtctgg tgcaggcacc agtgcaggga acgggtatgg caatccccga 660
aactcaccag gtctgctggt ctcacctggt aacttgaaca agaatatgca agcaaaatct 720
cctcccccaa tgaatttagg aatgaataac cgtaaaccag atctccgagt tcttattcca 780
ccaggcagca agaatacgat gccatcagtg tctgaggatg tcgacctgct tttgaatcaa 840
aggataaata actcccagtc ggctcagtca ttggctaccc cagtggtttc cgtagcaact 900
cctactttac caggacaagg aatgggagga tatccatcag ccatttcaac aacatatggt 960
accgagtact ctctgagtag tgcagacctg tcatctctgt ctgggtttaa caccgccagc 1020
gctcttcacc ttggttcagt aactggctgg caacagcaac acctacataa catgccacca 1080
tctgccctca gtcagttggg agcttgcact agcactcatt tatctcagag ttcaaatctc 1140
tccctgcctt ctactcaaag cctcaacatc aagtcagaac ctgtttctcc tcctagagac 1200
cgtaccacca ccccttcgag atacccacaa cacacgcgcc acgaggcggg gagatctcct 1260
gttgacagct tgagcagctg tagcagttcg tacgacggga gcgaccgaga ggatcaccgg 1320
aacgaattcc actcccccat tggactcacc agaccttcgc cggacgaaag ggaaagtccc 1380
tcagtcaagc gcatgcgact ttctgaagga tgggcaacat ga                    1422

<210> 19
<211> 513
<212> PRT
<213> Homo sapiens

<400> 19
Met Ala Asp Ala Asp Glu Ala Leu Ala Gly Ala His Leu Trp Ser Leu
 1               5                  10                  15      
Thr Gln Lys Thr Cys Leu Arg Phe Glu Pro Arg Ala Arg Ser Gly Pro
            20                  25                  30          
Pro Ala Ser Pro Pro Gly Arg Pro Arg Ser Arg Leu His Pro Ala Gly
        35                  40                  45              
Met Glu Gly Ile Lys Val Phe Leu His Glu Arg Glu Leu Trp Leu Lys
    50                  55                  60                  
Phe His Glu Val Thr Glu Met Ile Ile Thr Lys Ala Gly Arg Arg Met
65                  70                  75                  80  
Phe Pro Ser Tyr Lys Val Lys Val Thr Gly Ile Asn Pro Lys Thr Lys
                85                  90                  95      
Tyr Ile Leu Leu Met Asp Ile Val Pro Ala Asp Asp His Arg Tyr Lys
            100                 105                 110         
Phe Ala Asp Asn Lys Trp Cys Val Thr Gly Lys Ala Glu Pro Ala Met
        115                 120                 125             
Ala Gly Arg Leu Tyr Val His Pro Asp Ser Pro Ala Thr Gly Ala His
    130                 135                 140                 
Trp Met Arg Gln Leu Val Ser Phe Gln Lys Leu Lys Leu Thr Asn Asn
145                 150                 155                 160 
His Leu Asp Pro Phe Gly His Ile Ile Leu Asn Ser Met His Lys Tyr
                165                 170                 175     
Gln Pro Arg Leu His Ile Val Lys Ala Asp Glu Asn Asn Gly Phe Gly
            180                 185                 190         
Ser Lys Asn Thr Ala Phe Cys Thr His Val Phe Pro Glu Thr Ala Phe
        195                 200                 205             
Ile Ala Val Thr Ser Tyr Gln Asn His Lys Ile Thr Gln Leu Lys Ile
    210                 215                 220                 
Glu Asn Asn Pro Phe Ala Lys Gly Phe Arg Gly Ser Asp Asp Met Glu
225                 230                 235                 240 
Leu His Arg Met Ser Arg Met Gln Ser Lys Glu Tyr Pro Val Val Pro
                245                 250                 255     
Arg Ser Thr Val Arg Gln Lys Val Ala Ser Asn His Ser Pro Phe Ser
            260                 265                 270         
Ser Glu Ser Arg Ala Leu Ser Thr Ser Ser Asn Leu Gly Ser Gln Tyr
        275                 280                 285             
Gln Cys Glu Asn Gly Val Ser Gly Pro Ser Gln Asp Leu Leu Pro Pro
    290                 295                 300                 
Pro Asn Pro Tyr Pro Leu Pro Gln Glu His Ser Gln Ile Tyr His Cys
305                 310                 315                 320 
Thr Lys Arg Lys Glu Glu Glu Cys Ser Thr Thr Asp His Pro Tyr Lys
                325                 330                 335     
Lys Pro Tyr Met Glu Thr Ser Pro Ser Glu Glu Asp Ser Phe Tyr Arg
            340                 345                 350         
Ser Ser Tyr Pro Gln Gln Gln Gly Leu Gly Ala Ser Tyr Arg Thr Glu
        355                 360                 365             
Ser Ala Gln Arg Gln Ala Cys Met Tyr Ala Ser Ser Ala Pro Pro Ser
    370                 375                 380                 
Glu Pro Val Pro Ser Leu Glu Asp Ile Ser Cys Asn Thr Trp Pro Ser
385                 390                 395                 400 
Met Pro Ser Tyr Ser Ser Cys Thr Val Thr Thr Val Gln Pro Trp Thr
                405                 410                 415     
Gly Tyr Pro Thr Ser Thr Ser Pro Leu Thr Ser Pro Arg Gly Pro Trp
            420                 425                 430         
Ser Leu Gly Trp Leu Ala Trp Gln Pro Trp Leu Pro Thr Ala Gly Arg
        435                 440                 445             
Gly Asn Val Pro Ser Thr Arg Pro Pro Val Ala His Gln Pro Val Val
    450                 455                 460                 
Ser Ser Val Gly Pro Gln Thr Gly Leu Gln Ser Pro Gly Thr Leu Gln
465                 470                 475                 480 
Pro Pro Glu Phe Leu Tyr Ser His Gly Val Gln Gly Leu Tyr Pro Leu
                485                 490                 495     
Ile Ser Thr Thr Leu Cys Thr Glu Leu Ala Trp Cys Arg Val Glu Arg
            500                 505                 510         
Gln
    


<210> 20
<211> 1542
<212> DNA
<213> Homo sapiens

<400> 20
atggccgacg cagacgaggc tttggctggc gcacacctct ggagcctgac gcaaaagacc 60
tgcctgcgat tcgaaccgag agcgcgctcg gggcccccag caagtccccc cggtcgtccc 120
cgcagccgcc ttcacccagc aggcatggag ggaatcaaag tgtttctcca tgaaagagaa 180
ctgtggctaa aattccacga agtcacggaa atgatcataa ccaaggctgg aaggcggatg 240
tttcccagtt acaaagtgaa ggtgacgggc attaatccca aaacgaagta cattcttctc 300
atggacattg tacctgcgga cgatcacaga tacaaattcg cagataataa atggtgtgtg 360
acgggcaaag ctgagcccgc catggctggc cgcctgtacg tgcacccaga ctcccccgcc 420
accggggcgc attggatgag gcagctcgtc tccttccaga aactcaagct caccaacaac 480
cacctggacc catttgggca tattattcta aattccatgc acaaatacca gcctagatta 540
cacatcgtga aagcggatga aaataatgga tttggctcaa aaaatacagc gttctgcact 600
cacgtctttc ctgagactgc gtttatagca gtgacttcct accagaacca caagatcacg 660
caattaaaga ttgagaataa tccctttgcc aaaggatttc ggggcagtga tgacatggag 720
ctgcacagaa tgtcaagaat gcaaagtaaa gaatatcccg tggtccccag gagcaccgtg 780
aggcaaaaag tggcctccaa ccacagtcct ttcagcagcg agtctcgagc tctctccacc 840
tcatccaatt tggggtccca ataccagtgt gagaatggtg tttccggccc ctcccaggac 900
ctcctgcctc cacccaaccc atacccactg ccccaggagc atagccaaat ttaccattgt 960
accaagagga aagaggaaga atgttccacc acagaccatc cctataagaa gccctacatg 1020
gagacatcac ccagtgaaga agattccttc taccgctcta gctatccaca gcagcagggc 1080
ctgggtgcct cctacaggac agagtcggca cagcggcaag cttgcatgta tgccagctct 1140
gcgcccccca gcgagcctgt gcccagccta gaggacatca gctgcaacac gtggccaagc 1200
atgccttcct acagcagctg caccgtcacc accgtgcagc catggacagg ctaccctacc 1260
agcacttctc cgctcacttc acctcggggc ccctggtccc tcggctggct ggcatggcaa 1320
ccatggctcc ccacagctgg gagagggaat gttcccagca ccagacctcc cgtggcccac 1380
cagcctgtgg tcagcagtgt ggggccccaa actggcctgc agtcccctgg cacccttcag 1440
ccccctgagt tcctctactc tcatggcgtg caaggactct atcccctcat cagtaccact 1500
ctgtgcacgg agttggcatg gtgcagagtg gagcgacaat ag                    1542

<210> 21
<211> 518
<212> PRT
<213> Homo sapiens

<400> 21
Met Ala Asp Ala Asp Glu Gly Phe Gly Leu Ala His Thr Pro Leu Glu
 1               5                  10                  15      
Pro Asp Ala Lys Asp Leu Pro Cys Asp Ser Lys Pro Glu Ser Ala Leu
            20                  25                  30          
Gly Ala Pro Ser Lys Ser Pro Ser Ser Pro Gln Ala Ala Phe Thr Gln
        35                  40                  45              
Gln Gly Met Glu Gly Ile Lys Val Phe Leu His Glu Arg Glu Leu Trp
    50                  55                  60                  
Leu Lys Phe His Glu Val Gly Thr Glu Met Ile Ile Thr Lys Ala Gly
65                  70                  75                  80  
Arg Arg Met Phe Pro Ser Tyr Lys Val Lys Val Thr Gly Leu Asn Pro
                85                  90                  95      
Lys Thr Lys Tyr Ile Leu Leu Met Asp Ile Val Pro Ala Asp Asp His
            100                 105                 110         
Arg Tyr Lys Phe Ala Asp Asn Lys Trp Ser Val Thr Gly Lys Ala Glu
        115                 120                 125             
Pro Ala Met Pro Gly Arg Leu Tyr Val His Pro Asp Ser Pro Ala Thr
    130                 135                 140                 
Gly Ala His Trp Met Arg Gln Leu Val Ser Phe Gln Lys Leu Lys Leu
145                 150                 155                 160 
Thr Asn Asn His Leu Asp Pro Phe Gly His Ile Ile Leu Asn Ser Met
                165                 170                 175     
His Lys Tyr Gln Pro Arg Leu His Ile Val Lys Ala Asp Glu Asn Asn
            180                 185                 190         
Gly Phe Gly Ser Lys Asn Thr Ala Phe Cys Thr His Val Phe Pro Glu
        195                 200                 205             
Thr Ala Phe Ile Ala Val Thr Ser Tyr Gln Asn His Lys Ile Thr Gln
    210                 215                 220                 
Leu Lys Ile Glu Asn Asn Pro Phe Ala Lys Gly Phe Arg Gly Ser Asp
225                 230                 235                 240 
Asp Met Glu Leu His Arg Met Ser Arg Met Gln Ser Lys Glu Tyr Pro
                245                 250                 255     
Val Val Pro Arg Ser Thr Val Arg Gln Lys Val Ala Ser Asn His Ser
            260                 265                 270         
Pro Phe Ser Ser Glu Ser Arg Ala Leu Ser Thr Ser Ser Asn Leu Gly
        275                 280                 285             
Ser Gln Tyr Gln Cys Glu Asn Gly Val Ser Gly Pro Ser Gln Asp Leu
    290                 295                 300                 
Leu Pro Pro Pro Asn Pro Tyr Pro Leu Pro Gln Glu His Ser Gln Ile
305                 310                 315                 320 
Tyr His Cys Thr Lys Arg Lys Glu Glu Glu Cys Ser Thr Thr Asp His
                325                 330                 335     
Pro Tyr Lys Lys Pro Tyr Met Glu Thr Ser Pro Ser Glu Glu Asp Ser
            340                 345                 350         
Phe Tyr Arg Ser Ser Tyr Pro Gln Gln Gln Gly Leu Gly Ala Ser Tyr
        355                 360                 365             
Arg Thr Glu Ser Ala Gln Arg Gln Ala Cys Met Tyr Ala Ser Ser Ala
    370                 375                 380                 
Pro Pro Ser Glu Pro Val Pro Ser Leu Glu Asp Ile Ser Cys Asn Thr
385                 390                 395                 400 
Trp Pro Ser Met Pro Ser Tyr Ser Ser Cys Thr Val Thr Thr Val Gln
                405                 410                 415     
Pro Met Asp Arg Leu Pro Tyr Gln His Phe Ser Ala His Phe Thr Ser
            420                 425                 430         
Gly Pro Leu Val Pro Arg Leu Ala Gly Met Ala Asn His Gly Ser Pro
        435                 440                 445             
Gln Leu Gly Glu Gly Met Phe Gln His Gln Thr Ser Val Ala His Gln
    450                 455                 460                 
Pro Val Val Arg Gln Cys Gly Pro Gln Thr Gly Leu Gln Ser Pro Gly
465                 470                 475                 480 
Thr Leu Gln Pro Pro Glu Phe Leu Tyr Ser His Gly Val Pro Arg Thr
                485                 490                 495     
Leu Ser Pro His Gln Tyr His Ser Val His Gly Val Gly Met Val Pro
            500                 505                 510         
Glu Trp Ser Asp Asn Ser
        515             


<210> 22
<211> 1557
<212> DNA
<213> Homo sapiens

<400> 22
atggccgacg cagacgaggg ctttggcctg gcgcacacgc ctctggagcc tgacgcaaaa 60
gacctgccct gcgattcgaa acccgagagc gcgctcgggg cccccagcaa gtccccgtcg 120
tccccgcagg ccgccttcac ccagcagggc atggagggaa tcaaagtgtt tctccatgaa 180
agagaactgt ggctaaaatt ccacgaagtg ggcacggaaa tgatcataac caaggctgga 240
aggcggatgt ttcccagtta caaagtgaag gtgacgggcc ttaatcccaa aacgaagtac 300
attcttctca tggacattgt acctgccgac gatcacagat acaaattcgc agataataaa 360
tggtctgtga cgggcaaagc tgagcccgcc atgcctggcc gcctgtacgt gcacccagac 420
tcccccgcca ccggggcgca ttggatgagg cagctcgtct ccttccagaa actcaagctc 480
accaacaacc acctggaccc atttgggcat attattctaa attccatgca caaataccag 540
cctagattac acatcgtgaa agcggatgaa aataatggat ttggctcaaa aaatacagcg 600
ttctgcactc acgtctttcc tgagactgcg tttatagcag tgacttccta ccagaaccac 660
aagatcacgc aattaaagat tgagaataat ccctttgcca aaggatttcg gggcagtgat 720
gacatggagc tgcacagaat gtcaagaatg caaagtaaag aatatcccgt ggtccccagg 780
agcaccgtga ggcaaaaagt ggcctccaac cacagtcctt tcagcagcga gtctcgagct 840
ctctccacct catccaattt ggggtcccaa taccagtgtg agaatggtgt ttccggcccc 900
tcccaggacc tcctgcctcc acccaaccca tacccactgc cccaggagca tagccaaatt 960
taccattgta ccaagaggaa agaggaagaa tgttccacca cagaccatcc ctataagaag 1020
ccctacatgg agacatcacc cagtgaagaa gattccttct accgctctag ctatccacag 1080
cagcagggcc tgggtgcctc ctacaggaca gagtcggcac agcggcaagc ttgcatgtat 1140
gccagctctg cgccccccag cgagcctgtg cccagcctag aggacatcag ctgcaacacg 1200
tggccaagca tgccttccta cagcagctgc accgtcacca ccgtgcagcc catggacagg 1260
ctaccctacc agcacttctc cgctcacttc acctcggggc ccctggtccc tcggctggct 1320
ggcatggcca accatggctc cccacagctg ggagagggaa tgttccagca ccagacctcc 1380
gtggcccacc agcctgtggt caggcagtgt gggcctcaga ctggcctgca gtcccctggc 1440
acccttcagc cccctgagtt cctctactct catggcgtgc caaggactct atcccctcat 1500
cagtaccact ctgtgcacgg agttggcatg gtgccagagt ggagcgacaa tagctaa    1557

<210> 23
<211> 1302
<212> DNA
<213> Mus musculus

<400> 23
actatgggga gaaaaaagat tcagattacg aggataatgg atgagcgtaa cagacaggtg 60
acttttacga agaggaaatt tggattgatg aagaaggctt atgagctgag cgtgctgtgc 120
gactgtgaga ttgcactgat catcttcaac agcaccaaca agctgttcca gtacgccagc 180
actgacatgg ataaggtgtt gctcaagtac accgagtaca acgagccgca cgagagccgg 240
acaaactcag acattgtgga ggcattgaac aagaaagaaa acaaaggctc tgaaagcccc 300
gatcctgact cctcttatgc actcacccca cgcactgaag aaaaatacaa aaaaattaat 360
gaagaatttg ataatatgat caagagtcat aaaattcctg ctgttccacc tcccagcttt 420
gagatgccag ttaccatccc agtgtccagc cataacagtt tggtgtacag caatcctgtc 480
agcacactgg gaaaccccaa tcttctgcca ctggcccacc cgtctctgca gaggaatagt 540
atgtctcctg gtgtaacaca tagacctcca agtgcaggta acacaggcgg tctgatgggc 600
ggagatctga catccggtgc aggcaccagc gcagggaatg gatacggcaa cccccggaac 660
tcaccaggcc tgctggtctc acctggtaac ctgaacaaga atatacaagc caaatctcct 720
ccccctatga atctaggaat gaataatcgt aagccagatc tccgcgttct tatcccacct 780
ggcagcaaga acacgatgcc atcagtgaat caaaggataa ataactccca gtcggctcag 840
tcattggcta ccccggtggt ttccgtagca actcctactt taccaggaca aggaatggga 900
ggatatccat cagccatttc aacaacatat ggtactgagt actctctgag tagcgcagat 960
ctgtcatctc tgtctggctt caacactgcc agtgcgctcc acctcggctc tgtaactggc 1020
tggcagcagc agcacctaca taacatgccg ccatctgccc tcagtcagtt gggagaccgt 1080
accaccaccc cttcgagata cccacaacac accacgcgcc acgaggcggg gaggtctcct 1140
gttgacagct tgagcagctg tagcagttcc tacgatggga gcgaccgaga ggatcaccgg 1200
aacgaattcc actcccccat tggactcacc agaccttcgc cggacgaaag ggaaagtcct 1260
tcagtcaagc gcatgcgact ctctgaagga tgggcaacat ga                    1302

<210> 24
<211> 432
<212> PRT
<213> Mus musculus

<400> 24
Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn
 1               5                  10                  15      
Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala
            20                  25                  30          
Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe
        35                  40                  45              
Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys
    50                  55                  60                  
Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr
65                  70                  75                  80  
Asn Ser Asp Ile Val Glu Ala Leu Asn Lys Lys Glu Asn Lys Gly Ser
                85                  90                  95      
Glu Ser Pro Asp Pro Asp Ser Ser Tyr Ala Leu Thr Pro Arg Thr Glu
            100                 105                 110         
Glu Lys Tyr Lys Lys Ile Asn Glu Glu Phe Asp Asn Met Ile Lys Ser
        115                 120                 125             
His Lys Ile Pro Ala Val Pro Pro Pro Ser Phe Glu Met Pro Val Thr
    130                 135                 140                 
Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro Val Ser
145                 150                 155                 160 
Thr Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser Leu Gln
                165                 170                 175     
Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser Ala Gly
            180                 185                 190         
Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala Gly Thr
        195                 200                 205             
Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly Leu Leu
    210                 215                 220                 
Val Ser Pro Gly Asn Leu Asn Lys Asn Ile Gln Ala Lys Ser Pro Pro
225                 230                 235                 240 
Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg Val Leu
                245                 250                 255     
Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Asn Gln Arg Ile
            260                 265                 270         
Asn Asn Ser Gln Ser Ala Gln Ser Leu Ala Thr Pro Val Val Ser Val
        275                 280                 285             
Ala Thr Pro Thr Leu Pro Gly Gln Gly Met Gly Gly Tyr Pro Ser Ala
    290                 295                 300                 
Ile Ser Thr Thr Tyr Gly Thr Glu Tyr Ser Leu Ser Ser Ala Asp Leu
305                 310                 315                 320 
Ser Ser Leu Ser Gly Phe Asn Thr Ala Ser Ala Leu His Leu Gly Ser
                325                 330                 335     
Val Thr Gly Trp Gln Gln Gln His Leu His Asn Met Pro Pro Ser Ala
            340                 345                 350         
Leu Ser Gln Leu Gly Asp Arg Thr Thr Thr Pro Ser Arg Tyr Pro Gln
        355                 360                 365             
His Thr Thr Arg His Glu Ala Gly Arg Ser Pro Val Asp Ser Leu Ser
    370                 375                 380                 
Ser Cys Ser Ser Ser Tyr Asp Gly Ser Asp Arg Glu Asp His Arg Asn
385                 390                 395                 400 
Glu Phe His Ser Pro Ile Gly Leu Thr Arg Pro Ser Pro Asp Glu Arg
                405                 410                 415     
Glu Ser Pro Ser Val Lys Arg Met Arg Leu Ser Glu Gly Trp Ala Thr
            420                 425                 430         


<210> 25
<211> 1560
<212> DNA
<213> Mus musculus

<400> 25
accatggccg atacagatga gggctttggc ctggcgcgca cgcctctgga gcctgattcc 60
aaagacaggt cttgcgattc gaaacctgag agtgctctgg gggctcccag caagtctcca 120
tcatccccgc aggctgcctt cacccagcag ggcatggaag gaatcaaggt gtttcttcat 180
gaacgtgaac tgtggctgaa gttccacgaa gtgggcacag agatgatcat caccaaggca 240
gggaggagaa tgtttcctag ttacaaagtg aaggtgactg gccttaatcc caaaacgaag 300
tatattcttc tcatggatat tgttcccgca gacgaccaca gatataaatt tgctgataac 360
aaatggtccg taactggcaa agcagagcct gccatgccgg ggcgccttta cgtgcacccg 420
gactccccag caaccggagc ccactggatg cgacaacttg tctccttcca gaagctcaaa 480
ctcaccaaca accacctgga cccgtttgga cacattatcc tgaactccat gcacaaatac 540
cagccccgat tacacatcgt gaaagcagac gaaaataatg ggttcggttc aaagaacact 600
gcgttttgca cccacgtctt cccggagaca gcttttatcg ctgtgacttc gtaccagaat 660
cacaagatca cacagctgaa aattgagaac aaccccttcg ccaaaggctt tcggggcagt 720
gatgacctgg agttacacag gatgtctcgg atgcaaagta aagagtatcc tgtggttccc 780
aggagcacag tgaggcacaa agtcacctcc aaccacagcc ccttcagcag cgagacccga 840
gctctctcca cctcatccaa tttagggtcc cagtaccagt gtgagaatgg tgtctctggc 900
ccctcccagg accttctgcc cccacctaac ccatacccac tggcccagga gcacagccaa 960
atttaccact gtaccaagag gaaagatgag gaatgttcca gcacggagca cccctataag 1020
aagccgtaca tggagacatc ccccagcgag gaagacacct tctatcgctc gggctacccc 1080
cagcagcagg gcctgagtac ctcttacagg acagagtcgg cccagcggca ggcctgcatg 1140
tatgccagct ccgctccccc cagcgagccc gtgcctagcc tggaggacat cagctgtaac 1200
acatggccca gcatgccctc ctatagcagc tgtaccgtca ccaccgtgca gcccatggac 1260
cgtcttccct accagcactt ctccgctcat ttcacctcgg ggcccctggt ccctcggttg 1320
gctggcatgg ccaaccatgg ttctccccag ctcggcgaag ggatgtttca gcaccagacc 1380
tcagtggccc atcagcctgt ggtcaggcag tgcgggcctc agactggcct tcagtctccg 1440
ggcggcctcc agcccccaga gtttctctac actcacggcg tgcccaggac cctgtccccc 1500
catcagtatc actcggtaca cggcgtcggc atggtgccag agtggagtga gaatagctaa 1560


<210> 26
<211> 518
<212> PRT
<213> Mus musculus

<400> 26
Met Ala Asp Thr Asp Glu Gly Phe Gly Leu Ala Arg Thr Pro Leu Glu
 1               5                  10                  15      
Pro Asp Ser Lys Asp Arg Ser Cys Asp Ser Lys Pro Glu Ser Ala Leu
            20                  25                  30          
Gly Ala Pro Ser Lys Ser Pro Ser Ser Pro Gln Ala Ala Phe Thr Gln
        35                  40                  45              
Gln Gly Met Glu Gly Ile Lys Val Phe Leu His Glu Arg Glu Leu Trp
    50                  55                  60                  
Leu Lys Phe His Glu Val Gly Thr Glu Met Ile Ile Thr Lys Ala Gly
65                  70                  75                  80  
Arg Arg Met Phe Pro Ser Tyr Lys Val Lys Val Thr Gly Leu Asn Pro
                85                  90                  95      
Lys Thr Lys Tyr Ile Leu Leu Met Asp Ile Val Pro Ala Asp Asp His
            100                 105                 110         
Arg Tyr Lys Phe Ala Asp Asn Lys Trp Ser Val Thr Gly Lys Ala Glu
        115                 120                 125             
Pro Ala Met Pro Gly Arg Leu Tyr Val His Pro Asp Ser Pro Ala Thr
    130                 135                 140                 
Gly Ala His Trp Met Arg Gln Leu Val Ser Phe Gln Lys Leu Lys Leu
145                 150                 155                 160 
Thr Asn Asn His Leu Asp Pro Phe Gly His Ile Ile Leu Asn Ser Met
                165                 170                 175     
His Lys Tyr Gln Pro Arg Leu His Ile Val Lys Ala Asp Glu Asn Asn
            180                 185                 190         
Gly Phe Gly Ser Lys Asn Thr Ala Phe Cys Thr His Val Phe Pro Glu
        195                 200                 205             
Thr Ala Phe Ile Ala Val Thr Ser Tyr Gln Asn His Lys Ile Thr Gln
    210                 215                 220                 
Leu Lys Ile Glu Asn Asn Pro Phe Ala Lys Gly Phe Arg Gly Ser Asp
225                 230                 235                 240 
Asp Leu Glu Leu His Arg Met Ser Arg Met Gln Ser Lys Glu Tyr Pro
                245                 250                 255     
Val Val Pro Arg Ser Thr Val Arg His Lys Val Thr Ser Asn His Ser
            260                 265                 270         
Pro Phe Ser Ser Glu Thr Arg Ala Leu Ser Thr Ser Ser Asn Leu Gly
        275                 280                 285             
Ser Gln Tyr Gln Cys Glu Asn Gly Val Ser Gly Pro Ser Gln Asp Leu
    290                 295                 300                 
Leu Pro Pro Pro Asn Pro Tyr Pro Leu Ala Gln Glu His Ser Gln Ile
305                 310                 315                 320 
Tyr His Cys Thr Lys Arg Lys Asp Glu Glu Cys Ser Ser Thr Glu His
                325                 330                 335     
Pro Tyr Lys Lys Pro Tyr Met Glu Thr Ser Pro Ser Glu Glu Asp Thr
            340                 345                 350         
Phe Tyr Arg Ser Gly Tyr Pro Gln Gln Gln Gly Leu Ser Thr Ser Tyr
        355                 360                 365             
Arg Thr Glu Ser Ala Gln Arg Gln Ala Cys Met Tyr Ala Ser Ser Ala
    370                 375                 380                 
Pro Pro Ser Glu Pro Val Pro Ser Leu Glu Asp Ile Ser Cys Asn Thr
385                 390                 395                 400 
Trp Pro Ser Met Pro Ser Tyr Ser Ser Cys Thr Val Thr Thr Val Gln
                405                 410                 415     
Pro Met Asp Arg Leu Pro Tyr Gln His Phe Ser Ala His Phe Thr Ser
            420                 425                 430         
Gly Pro Leu Val Pro Arg Leu Ala Gly Met Ala Asn His Gly Ser Pro
        435                 440                 445             
Gln Leu Gly Glu Gly Met Phe Gln His Gln Thr Ser Val Ala His Gln
    450                 455                 460                 
Pro Val Val Arg Gln Cys Gly Pro Gln Thr Gly Leu Gln Ser Pro Gly
465                 470                 475                 480 
Gly Leu Gln Pro Pro Glu Phe Leu Tyr Thr His Gly Val Pro Arg Thr
                485                 490                 495     
Leu Ser Pro His Gln Tyr His Ser Val His Gly Val Gly Met Val Pro
            500                 505                 510         
Glu Trp Ser Glu Asn Ser
        515             


<210> 27
<211> 1329
<212> DNA
<213> Mus musculus

<400> 27
gcgatgtacc aaagcctggc catggccgcc aaccacggcc ccccgcccgg cgcctacgaa 60
gcaggtggcc ctggcgcctt catgcacagc gcgggcgccg cgtcctcgcc cgtctacgtg 120
cccactccgc gggtgccgtc ctctgtgctg ggcctgtcct acctgcaggg cggtggcagt 180
gccgctgcag ctggaaccac ctcgggtggc agctccgggg ccggcccgtc gggtgcaggg 240
cctgggaccc agcagggtag ccctggctgg agccaagctg gagccgaggg agccgcctac 300
accccgccgc ccgtgtcccc gcgcttctct ttcccgggga ctactgggtc cctggcggcc 360
gctgccgccg ctgccgcagc ccgggaagct gcagcctacg gcagtggcgg cggggcggcg 420
ggcgctggtc tggctggccg agagcagtac gggcgtccgg gcttcgccgg ctcctactcc 480
agcccctacc cagcctacat ggccgacgtg ggagcatcct gggccgcagc cgctgccgcc 540
tctgccggcc ccttcgacag cccagtcctg cacagcctgc ctggacgggc caaccctgga 600
agacacccca atctcgatat gtttgatgac ttctcagaag gcagagagtg tgtcaattgt 660
ggggccatgt ccaccccact ctggaggcga gatgggacgg gacactacct gtgcaatgcc 720
tgtggcctct atcacaagat gaacggcatc aaccggcccc tcattaagcc tcagcgccgc 780
ctgtccgctt cccgccgggt aggcctctcc tgtgccaact gccagactac caccaccacg 840
ctgtggcgtc gtaatgccga gggtgagcct gtatgtaatg cctgcggcct ctacatgaag 900
ctccatgggg ttcccaggcc tcttgcaatg cggaaggagg ggattcaaac cagaaaacgg 960
aagcccaaga acctgaataa atctaagacg ccagcaggtc ctgctggtga gaccctccct 1020
ccctccagtg gtgcctccag cggtaactcc agcaatgcca ctagcagcag cagcagcagt 1080
gaagagatgc gccccatcaa gacagagccc gggctgtcat ctcactatgg gcacagcagc 1140
tccatgtccc agacattcag tactgtgtcc ggccacgggc cctccatcca tccagtgctg 1200
tctgctctga agctgtcccc acaaggctat gcatctcctg tcactcagac atcgcaggcc 1260
agctccaagc aggactcttg gaacagcctg gtcctggctg acagtcatgg ggacataatc 1320
accgcgtaa                                                         1329

<210> 28
<211> 441
<212> PRT
<213> Mus musculus

<400> 28
Met Tyr Gln Ser Leu Ala Met Ala Ala Asn His Gly Pro Pro Pro Gly
 1               5                  10                  15      
Ala Tyr Glu Ala Gly Gly Pro Gly Ala Phe Met His Ser Ala Gly Ala
            20                  25                  30          
Ala Ser Ser Pro Val Tyr Val Pro Thr Pro Arg Val Pro Ser Ser Val
        35                  40                  45              
Leu Gly Leu Ser Tyr Leu Gln Gly Gly Gly Ser Ala Ala Ala Ala Gly
    50                  55                  60                  
Thr Thr Ser Gly Gly Ser Ser Gly Ala Gly Pro Ser Gly Ala Gly Pro
65                  70                  75                  80  
Gly Thr Gln Gln Gly Ser Pro Gly Trp Ser Gln Ala Gly Ala Glu Gly
                85                  90                  95      
Ala Ala Tyr Thr Pro Pro Pro Val Ser Pro Arg Phe Ser Phe Pro Gly
            100                 105                 110         
Thr Thr Gly Ser Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Arg Glu
        115                 120                 125             
Ala Ala Ala Tyr Gly Ser Gly Gly Gly Ala Ala Gly Ala Gly Leu Ala
    130                 135                 140                 
Gly Arg Glu Gln Tyr Gly Arg Pro Gly Phe Ala Gly Ser Tyr Ser Ser
145                 150                 155                 160 
Pro Tyr Pro Ala Tyr Met Ala Asp Val Gly Ala Ser Trp Ala Ala Ala
                165                 170                 175     
Ala Ala Ala Ser Ala Gly Pro Phe Asp Ser Pro Val Leu His Ser Leu
            180                 185                 190         
Pro Gly Arg Ala Asn Pro Gly Arg His Pro Asn Leu Asp Met Phe Asp
        195                 200                 205             
Asp Phe Ser Glu Gly Arg Glu Cys Val Asn Cys Gly Ala Met Ser Thr
    210                 215                 220                 
Pro Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys
225                 230                 235                 240 
Gly Leu Tyr His Lys Met Asn Gly Ile Asn Arg Pro Leu Ile Lys Pro
                245                 250                 255     
Gln Arg Arg Leu Ser Ala Ser Arg Arg Val Gly Leu Ser Cys Ala Asn
            260                 265                 270         
Cys Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly Glu
        275                 280                 285             
Pro Val Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val Pro
    290                 295                 300                 
Arg Pro Leu Ala Met Arg Lys Glu Gly Ile Gln Thr Arg Lys Arg Lys
305                 310                 315                 320 
Pro Lys Asn Leu Asn Lys Ser Lys Thr Pro Ala Gly Pro Ala Gly Glu
                325                 330                 335     
Thr Leu Pro Pro Ser Ser Gly Ala Ser Ser Gly Asn Ser Ser Asn Ala
            340                 345                 350         
Thr Ser Ser Ser Ser Ser Ser Glu Glu Met Arg Pro Ile Lys Thr Glu
        355                 360                 365             
Pro Gly Leu Ser Ser His Tyr Gly His Ser Ser Ser Met Ser Gln Thr
    370                 375                 380                 
Phe Ser Thr Val Ser Gly His Gly Pro Ser Ile His Pro Val Leu Ser
385                 390                 395                 400 
Ala Leu Lys Leu Ser Pro Gln Gly Tyr Ala Ser Pro Val Thr Gln Thr
                405                 410                 415     
Ser Gln Ala Ser Ser Lys Gln Asp Ser Trp Asn Ser Leu Val Leu Ala
            420                 425                 430         
Asp Ser His Gly Asp Ile Ile Thr Ala
        435                 440     


<210> 29
<211> 268
<212> PRT
<213> Homo sapiens

<400> 29
Met Ala Gln Pro Leu Cys Pro Pro Leu Ser Glu Ser Trp Met Leu Ser
 1               5                  10                  15      
Ala Ala Trp Gly Pro Thr Arg Arg Pro Pro Pro Ser Asp Lys Asp Cys
            20                  25                  30          
Gly Arg Ser Leu Val Ser Ser Pro Asp Ser Trp Gly Ser Thr Pro Ala
        35                  40                  45              
Asp Ser Pro Val Ala Ser Pro Ala Arg Pro Gly Thr Leu Arg Asp Pro
    50                  55                  60                  
Arg Ala Pro Ser Val Gly Arg Arg Gly Ala Arg Ser Ser Arg Leu Gly
65                  70                  75                  80  
Ser Gly Gln Arg Gln Ser Ala Ser Glu Arg Glu Lys Leu Arg Met Arg
                85                  90                  95      
Thr Leu Ala Arg Ala Leu His Glu Leu Arg Arg Phe Leu Pro Pro Ser
            100                 105                 110         
Val Ala Pro Ala Gly Gln Ser Leu Thr Lys Ile Glu Thr Leu Arg Leu
        115                 120                 125             
Ala Ile Arg Tyr Ile Gly His Leu Ser Ala Val Leu Gly Leu Ser Glu
    130                 135                 140                 
Glu Ser Leu Gln Arg Arg Cys Arg Gln Arg Gly Asp Ala Gly Ser Pro
145                 150                 155                 160 
Arg Gly Cys Pro Leu Cys Pro Asp Asp Cys Pro Ala Gln Met Gln Thr
                165                 170                 175     
Arg Thr Gln Ala Glu Gly Gln Gly Gln Gly Arg Gly Leu Gly Leu Val
            180                 185                 190         
Ser Ala Val Arg Ala Gly Ala Ser Trp Gly Ser Pro Pro Ala Cys Pro
        195                 200                 205             
Gly Ala Arg Ala Ala Pro Glu Pro Arg Asp Pro Pro Ala Leu Phe Ala
    210                 215                 220                 
Glu Ala Ala Cys Pro Glu Gly Gln Ala Met Glu Pro Ser Pro Pro Ser
225                 230                 235                 240 
Pro Leu Leu Pro Gly Asp Val Leu Ala Leu Leu Glu Thr Trp Met Pro
                245                 250                 255     
Leu Ser Pro Leu Glu Trp Leu Pro Glu Glu Pro Lys
            260                 265             


<210> 30
<211> 807
<212> DNA
<213> Homo sapiens

<400> 30
atggcccagc ccctgtgccc gccgctctcc gagtcctgga tgctctctgc ggcctggggc 60
ccaactcggc ggccgccgcc ctccgacaag gactgcggcc gctccctcgt ctcgtcccca 120
gactcatggg gcagcacccc agccgacagc cccgtggcga gccccgcgcg gccaggcacc 180
ctccgggacc cccgcgcccc ctccgtaggt aggcgcggcg cgcgcagcag ccgcctgggc 240
agcgggcaga ggcagagcgc cagtgagcgg gagaaactgc gcatgcgcac gctggcccgc 300
gccctgcacg agctgcgccg ctttctaccg ccgtccgtgg cgcccgcggg ccagagcctg 360
accaagatcg agacgctgcg cctggctatc cgctatatcg gccacctgtc ggccgtgcta 420
ggcctcagcg aggagagtct ccagcgccgg tgccggcagc gcggtgacgc ggggtcccct 480
cggggctgcc cgctgtgccc cgacgactgc cccgcgcaga tgcagacacg gacgcaggct 540
gaggggcagg ggcaggggcg cgggctgggc ctggtatccg ccgtccgcgc cggggcgtcc 600
tggggatccc cgcctgcctg ccccggagcc cgagctgcac ccgagccgcg cgacccgcct 660
gcgctgttcg ccgaggcggc gtgccctgaa gggcaggcga tggagccaag cccaccgtcc 720
ccgctccttc cgggcgacgt gctggctctg ttggagacct ggatgcccct ctcgcctctg 780
gagtggctgc ctgaggagcc caagtga                                     807

<210> 31
<211> 149
<212> PRT
<213> Homo sapiens

<400> 31
Met Phe Pro Ser Pro Ala Leu Thr Pro Thr Pro Phe Ser Val Lys Asp
 1               5                  10                  15      
Ile Leu Asn Leu Glu Gln Gln Gln Arg Ser Leu Ala Ala Ala Gly Glu
            20                  25                  30          
Leu Ser Ala Arg Leu Glu Ala Thr Ala Pro Ser Ser Cys Met Leu Ala
        35                  40                  45              
Ala Lys Pro Glu Ala Tyr Ala Gly Pro Glu Ala Ala Ala Pro Gly Leu
    50                  55                  60                  
Pro Glu Leu Arg Ala Glu Leu Gly Arg Ala Pro Ser Pro Ala Lys Cys
65                  70                  75                  80  
Ala Ser Ala Phe Pro Ala Ala Pro Ala Phe Tyr Pro Arg Ala Tyr Ser
                85                  90                  95      
Asp Pro Asp Pro Ala Lys Asp Pro Arg Ala Glu Lys Lys Gly Cys Glu
            100                 105                 110         
Leu Pro Arg Gly Gln Arg Pro Pro Val Leu Phe Ser Ser Ala Leu Ser
        115                 120                 125             
Gln Pro Asp Phe Leu Gln Met Leu Ser Glu Thr Cys Arg Trp Leu Pro
    130                 135                 140                 
Val His Leu Ala Glu
145                 


<210> 32
<211> 456
<212> DNA
<213> Homo sapiens

<400> 32
atgttcccca gccctgctct cacgcccacg cccttctcag tcaaagacat cctaaacctg 60
gaacagcagc agcgcagcct ggctgccgcc ggagagctct ctgcccgcct ggaggcgacc 120
ctggcgccct cctcctgcat gctggccgcc ttcaagccag aggcctacgc tgggcccgag 180
gcggctgcgc cgggcctccc agagctgcgc gcagagctgg gccgcgcgcc ttcaccggcc 240
aagtgtgcgt ctgcctttcc cgccgccccc gccttctatc cacgtgccta cagcgacccc 300
gacccagcca aggaccctag agccgaaaag aaagggtgtg aactgccccg agggcagaga 360
cctcccgttt tgttctccag cgccttgagc cagcctgact ttctacaaat gctgagtgag 420
acgtgtcggt ggctcccagt gcacttggca gagtga                           456

<210> 33
<211> 324
<212> PRT
<213> Homo sapiens

<400> 33
Met Phe Pro Ser Pro Ala Leu Thr Pro Thr Pro Phe Ser Val Lys Asp
 1               5                  10                  15      
Ile Leu Asn Leu Glu Gln Gln Gln Arg Ser Leu Ala Ala Ala Gly Glu
            20                  25                  30          
Leu Ser Ala Arg Leu Glu Ala Thr Leu Ala Pro Ser Ser Cys Met Leu
        35                  40                  45              
Ala Ala Phe Lys Pro Glu Ala Tyr Ala Gly Pro Glu Ala Ala Ala Pro
    50                  55                  60                  
Gly Leu Pro Glu Leu Arg Ala Glu Leu Gly Arg Ala Pro Ser Pro Ala
65                  70                  75                  80  
Lys Cys Ala Ser Ala Phe Pro Ala Ala Pro Ala Phe Tyr Pro Arg Ala
                85                  90                  95      
Tyr Ser Asp Pro Asp Pro Ala Lys Asp Pro Arg Ala Glu Lys Lys Glu
            100                 105                 110         
Leu Cys Ala Leu Gln Lys Ala Val Glu Leu Glu Lys Thr Glu Ala Asp
        115                 120                 125             
Asn Ala Glu Arg Pro Arg Ala Arg Arg Arg Arg Lys Pro Arg Val Leu
    130                 135                 140                 
Phe Ser Gln Ala Gln Val Tyr Glu Leu Glu Arg Arg Phe Lys Gln Gln
145                 150                 155                 160 
Arg Tyr Leu Ser Ala Pro Glu Arg Asp Gln Leu Ala Ser Val Leu Lys
                165                 170                 175     
Leu Thr Ser Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys
            180                 185                 190         
Cys Lys Arg Gln Arg Gln Asp Gln Thr Leu Glu Leu Val Gly Leu Pro
        195                 200                 205             
Pro Pro Pro Pro Pro Pro Ala Arg Arg Ile Ala Val Pro Val Leu Val
    210                 215                 220                 
Arg Asp Gly Lys Pro Cys Leu Gly Asp Ser Ala Pro Tyr Ala Pro Ala
225                 230                 235                 240 
Tyr Gly Val Gly Leu Asn Pro Tyr Gly Tyr Asn Ala Tyr Pro Ala Tyr
                245                 250                 255     
Pro Gly Tyr Gly Gly Ala Ala Cys Ser Pro Gly Tyr Ser Cys Thr Ala
            260                 265                 270         
Ala Tyr Pro Ala Gly Pro Ser Pro Ala Gln Pro Ala Thr Ala Ala Ala
        275                 280                 285             
Asn Asn Asn Phe Val Asn Phe Gly Val Gly Asp Leu Asn Ala Val Gln
    290                 295                 300                 
Ser Pro Gly Ile Pro Gln Ser Asn Ser Gly Val Ser Thr Leu His Gly
305                 310                 315                 320 
Ile Arg Ala Trp
                


<210> 34
<211> 975
<212> DNA
<213> Homo sapiens

<400> 34
atgttcccca gccctgctct cacgcccacg cccttctcag tcaaagacat cctaaacctg 60
gaacagcagc agcgcagcct ggctgccgcc ggagagctct ctgcccgcct ggaggcgacc 120
ctggcgccct cctcctgcat gctggccgcc ttcaagccag aggcctacgc tgggcccgag 180
gcggctgcgc cgggcctccc agagctgcgc gcagagctgg gccgcgcgcc ttcaccggcc 240
aagtgtgcgt ctgcctttcc cgccgccccc gccttctatc cacgtgccta cagcgacccc 300
gacccagcca aggaccctag agccgaaaag aaagagctgt gcgcgctgca gaaggcggtg 360
gagctggaga agacagaggc ggacaacgcg gagcggcccc gggcgcgacg gcggaggaag 420
ccgcgcgtgc tcttctcgca ggcgcaggtc tatgagctgg agcggcgctt caagcagcag 480
cggtacctgt cggcccccga acgcgaccag ctggccagcg tgctgaaact cacgtccacg 540
caggtcaaga tctggttcca gaaccggcgc tacaagtgca agcggcagcg gcaggaccag 600
actctggagc tggtggggct gcccccgccg ccgccgccgc ctgcccgcag gatcgcggtg 660
ccagtgctgg tgcgcgatgg caagccatgc ctaggggact cggcgcccta cgcgcctgcc 720
tacggcgtgg gcctcaatcc ctacggttat aacgcctacc ccgcctatcc gggttacggc 780
ggcgcggcct gcagccctgg ctacagctgc actgccgctt accccgccgg gccttcccca 840
gcgcagccgg ccactgccgc cgccaacaac aacttcgtga acttcggcgt cggggacttg 900
aatgcggttc agagccccgg gattccgcag agcaactcgg gagtgtccac gctgcatggt 960
atccgagcct ggtag                                                  975

<210> 35
<211> 112
<212> PRT
<213> Homo sapiens

<400> 35
Met Phe Pro Ser Pro Ala Leu Thr Pro Thr Pro Phe Ser Val Lys Asp
 1               5                  10                  15      
Ile Leu Asn Leu Glu Gln Gln Gln Arg Ser Leu Ala Ala Ala Gly Glu
            20                  25                  30          
Leu Ser Ala Arg Leu Glu Ala Thr Leu Ala Pro Ser Ser Cys Met Leu
        35                  40                  45              
Ala Ala Phe Lys Pro Glu Ala Tyr Ala Gly Pro Glu Ala Ala Ala Pro
    50                  55                  60                  
Gly Leu Pro Glu Leu Arg Ala Glu Leu Gly Arg Ala Pro Ser Pro Ala
65                  70                  75                  80  
Lys Cys Ala Ser Ala Phe Pro Ala Ala Pro Ala Phe Tyr Pro Arg Ala
                85                  90                  95      
Tyr Ser Asp Pro Asp Pro Ala Lys Asp Pro Arg Ala Glu Lys Lys Ala
            100                 105                 110         


<210> 36
<211> 339
<212> DNA
<213> Homo sapiens

<400> 36
atgttcccca gccctgctct cacgcccacg cccttctcag tcaaagacat cctaaacctg 60
gaacagcagc agcgcagcct ggctgccgcc ggagagctct ctgcccgcct ggaggcgacc 120
ctggcgccct cctcctgcat gctggccgcc ttcaagccag aggcctacgc tgggcccgag 180
gcggctgcgc cgggcctccc agagctgcgc gcagagctgg gccgcgcgcc ttcaccggcc 240
aagtgtgcgt ctgcctttcc cgccgccccc gccttctatc cacgtgccta cagcgacccc 300
gacccagcca aggaccctag agccgaaaag aaagcctga                        339

<210> 37
<211> 346
<212> PRT
<213> Homo sapiens

<400> 37
Met Gly Asp Pro Pro Lys Lys Lys Arg Leu Ile Ser Leu Cys Val Gly
 1               5                  10                  15      
Cys Gly Asn Gln Ile His Asp Gln Tyr Ile Leu Arg Val Ser Pro Asp
            20                  25                  30          
Leu Glu Trp His Ala Ala Cys Leu Lys Cys Ala Glu Cys Asn Gln Tyr
        35                  40                  45              
Leu Asp Glu Ser Cys Thr Cys Phe Val Arg Asp Gly Lys Thr Tyr Cys
    50                  55                  60                  
Lys Arg Asp Tyr Ile Arg Leu Tyr Gly Ile Lys Cys Ala Lys Cys Ser
65                  70                  75                  80  
Ile Gly Phe Ser Lys Asn Asp Phe Val Met Arg Ala Arg Ser Lys Val
                85                  90                  95      
Tyr His Ile Glu Cys Phe Arg Cys Val Ala Cys Ser Arg Gln Leu Ile
            100                 105                 110         
Pro Gly Asp Glu Phe Ala Leu Arg Glu Asp Gly Leu Phe Cys Arg Ala
        115                 120                 125             
Asp His Asp Val Val Glu Arg Ala Ser Leu Gly Ala Gly Asp Pro Leu
    130                 135                 140                 
Ser Pro Leu His Pro Ala Arg Pro Leu Gln Met Ala Ala Glu Pro Ile
145                 150                 155                 160 
Ser Ala Arg Gln Pro Ala Leu Arg Pro His Val His Lys Gln Pro Glu
                165                 170                 175     
Lys Thr Thr Arg Val Arg Thr Val Leu Asn Glu Lys Gln Leu His Thr
            180                 185                 190         
Leu Arg Thr Cys Tyr Ala Ala Asn Pro Arg Pro Asp Ala Leu Met Lys
        195                 200                 205             
Glu Gln Leu Val Glu Met Thr Gly Leu Ser Pro Arg Val Ile Arg Val
    210                 215                 220                 
Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys Arg Ser Ile Met Met
225                 230                 235                 240 
Lys Gln Leu Gln Gln Gln Gln Pro Asn Asp Lys Thr Asn Ile Gln Gly
                245                 250                 255     
Met Thr Gly Thr Pro Met Val Ala Ala Ser Pro Glu Arg His Asp Gly
            260                 265                 270         
Gly Leu Gln Ala Asn Pro Val Glu Val Gln Ser Tyr Gln Pro Pro Trp
        275                 280                 285             
Lys Val Leu Ser Asp Phe Ala Leu Gln Ser Asp Ile Asp Gln Pro Ala
    290                 295                 300                 
Phe Gln Gln Leu Val Asn Phe Ser Glu Gly Gly Pro Gly Ser Asn Ser
305                 310                 315                 320 
Thr Gly Ser Glu Val Ala Ser Met Ser Ser Gln Leu Pro Asp Thr Pro
                325                 330                 335     
Asn Ser Met Val Ala Ser Pro Ile Glu Ala
            340                 345     


<210> 38
<211> 1041
<212> DNA
<213> Homo sapiens

<400> 38
atgggagatc caccaaaaaa aaaacgtctg atttccctat gtgttggttg cggcaatcag 60
attcacgatc agtatattct gagggtttct ccggatttgg aatggcatgc ggcatgtttg 120
aaatgtgcgg agtgtaatca gtatttggac gagagctgta catgctttgt tagggatggg 180
aaaacctact gtaaaagaga ttatatcagg ttgtacggga tcaaatgcgc caagtgcagc 240
atcggcttca gcaagaacga cttcgtgatg cgtgcccgct ccaaggtgta tcacatcgag 300
tgtttccgct gtgtggcctg cagccgccag ctcatccctg gggacgaatt tgcgcttcgg 360
gaggacggtc tcttctgccg agcagaccac gatgtggtgg agagggccag tctaggcgct 420
ggcgacccgc tcagtcccct gcatccagcg cggccactgc aaatggcagc ggagcccatc 480
tccgccaggc agccagccct gcggccccac gtccacaagc agccggagaa gaccacccgc 540
gtgcggactg tgctgaacga gaagcagctg cacaccttgc ggacctgcta cgccgcaaac 600
ccgcggccag atgcgctcat gaaggagcaa ctggtagaga tgacgggcct cagtccccgt 660
gtgatccggg tctggtttca aaacaagcgg tgcaaggaca agaagcgaag catcatgatg 720
aagcaactcc agcagcagca gcccaatgac aaaactaata tccaggggat gacaggaact 780
cccatggtgg ctgccagtcc agagagacac gacggtggct tacaggctaa cccagtggaa 840
gtacaaagtt accagccacc ttggaaagta ctgagcgact tcgccttgca gagtgacata 900
gatcagcctg cttttcagca actggtcaat ttttcagaag gaggaccggg ctctaattcc 960
actggcagtg aagtagcatc aatgtcctct caacttccag atacacctaa cagcatggta 1020
gccagtccta ttgaggcatg a                                           1041

<210> 39
<211> 684
<212> PRT
<213> Homo sapiens

<400> 39
Met Lys Leu Lys Arg Ala Arg Leu Ala Asp Asp Leu Asn Glu Lys Ile
 1               5                  10                  15      
Ala Leu Arg Pro Gly Pro Leu Glu Leu Val Glu Lys Asn Ile Leu Pro
            20                  25                  30          
Val Asp Ser Ala Val Lys Glu Ala Ile Lys Gly Asn Gln Val Ser Phe
        35                  40                  45              
Ser Lys Ser Thr Asp Ala Phe Ala Phe Glu Glu Asp Ser Ser Ser Asp
    50                  55                  60                  
Gly Leu Ser Pro Asp Gln Thr Arg Ser Glu Asp Pro Gln Asn Ser Ala
65                  70                  75                  80  
Gly Ser Pro Pro Asp Ala Lys Ala Ser Asp Thr Pro Ser Thr Gly Ser
                85                  90                  95      
Leu Gly Thr Asn Gln Asp Leu Ala Ser Gly Ser Glu Asn Asp Arg Asn
            100                 105                 110         
Asp Ser Ala Ser Gln Pro Ser His Gln Ser Asp Ala Gly Lys Gln Gly
        115                 120                 125             
Leu Gly Pro Pro Ser Thr Pro Ile Ala Val His Ala Ala Val Lys Ser
    130                 135                 140                 
Lys Ser Leu Gly Asp Ser Lys Asn Arg His Lys Lys Pro Lys Asp Pro
145                 150                 155                 160 
Lys Pro Lys Val Lys Lys Leu Lys Tyr His Gln Tyr Ile Pro Pro Asp
                165                 170                 175     
Gln Lys Ala Glu Lys Ser Pro Pro Pro Met Asp Ser Ala Tyr Ala Arg
            180                 185                 190         
Leu Leu Gln Gln Gln Gln Leu Phe Leu Gln Leu Gln Ile Leu Ser Gln
        195                 200                 205             
Gln Gln Gln Gln Gln Gln His Arg Phe Ser Tyr Leu Gly Met His Gln
    210                 215                 220                 
Ala Gln Leu Lys Glu Pro Asn Glu Gln Met Val Arg Asn Pro Asn Ser
225                 230                 235                 240 
Ser Ser Thr Pro Leu Ser Asn Thr Pro Leu Ser Pro Val Lys Asn Ser
                245                 250                 255     
Phe Ser Gly Gln Thr Gly Val Ser Ser Phe Lys Pro Gly Pro Leu Pro
            260                 265                 270         
Pro Asn Leu Asp Asp Leu Lys Val Ser Glu Leu Arg Gln Gln Leu Arg
        275                 280                 285             
Ile Arg Gly Leu Pro Val Ser Gly Thr Lys Thr Ala Leu Met Asp Arg
    290                 295                 300                 
Leu Arg Pro Phe Gln Asp Cys Ser Gly Asn Pro Val Pro Asn Phe Gly
305                 310                 315                 320 
Asp Ile Thr Thr Val Thr Phe Pro Val Thr Pro Asn Thr Leu Pro Asn
                325                 330                 335     
Tyr Gln Ser Ser Ser Ser Thr Ser Ala Leu Ser Asn Gly Phe Tyr His
            340                 345                 350         
Phe Gly Ser Thr Ser Ser Ser Pro Pro Ile Ser Pro Ala Ser Ser Asp
        355                 360                 365             
Leu Ser Val Ala Gly Ser Leu Pro Asp Thr Phe Asn Asp Ala Ser Pro
    370                 375                 380                 
Ser Phe Gly Leu His Pro Ser Pro Val His Val Cys Thr Glu Glu Ser
385                 390                 395                 400 
Leu Met Ser Ser Leu Asn Gly Gly Ser Val Pro Ser Glu Leu Asp Gly
                405                 410                 415     
Leu Asp Ser Glu Lys Asp Lys Met Leu Val Glu Lys Gln Lys Val Ile
            420                 425                 430         
Asn Glu Leu Thr Trp Lys Leu Gln Gln Glu Gln Arg Gln Val Glu Glu
        435                 440                 445             
Leu Arg Met Gln Leu Gln Lys Gln Lys Arg Asn Asn Cys Ser Glu Lys
    450                 455                 460                 
Lys Pro Leu Pro Phe Leu Ala Ala Ser Ile Lys Gln Glu Glu Ala Val
465                 470                 475                 480 
Ser Ser Cys Pro Phe Ala Ser Gln Val Pro Val Lys Arg Gln Ser Ser
                485                 490                 495     
Ser Ser Glu Cys His Pro Pro Ala Cys Glu Ala Ala Gln Leu Gln Pro
            500                 505                 510         
Leu Gly Asn Ala His Cys Val Glu Ser Ser Asp Gln Thr Asn Val Leu
        515                 520                 525             
Ser Ser Thr Phe Leu Ser Pro Gln Cys Ser Pro Gln His Ser Pro Leu
    530                 535                 540                 
Gly Ala Val Lys Ser Pro Gln His Ile Ser Leu Pro Pro Ser Pro Asn
545                 550                 555                 560 
Asn Pro His Phe Leu Pro Ser Ser Ser Gly Ala Gln Gly Glu Gly His
                565                 570                 575     
Arg Val Ser Ser Pro Ile Ser Ser Gln Val Cys Thr Ala Gln Asn Ser
            580                 585                 590         
Gly Ala His Asp Gly His Pro Pro Ser Phe Ser Pro His Ser Ser Ser
        595                 600                 605             
Leu His Pro Pro Phe Ser Gly Ala Gln Ala Asp Ser Ser His Gly Ala
    610                 615                 620                 
Gly Gly Asn Pro Cys Pro Lys Ser Pro Cys Val Gln Gln Lys Met Ala
625                 630                 635                 640 
Gly Leu His Ser Ser Asp Lys Val Gly Pro Lys Phe Ser Ile Pro Ser
                645                 650                 655     
Pro Thr Phe Ser Lys Ser Ser Ser Ala Ile Ser Glu Val Thr Gln Pro
            660                 665                 670         
Pro Ser Tyr Glu Asp Ala Val Lys Gln Val Thr Met
        675                 680                 


<210> 40
<211> 2055
<212> DNA
<213> Homo sapiens

<400> 40
atgaagctga aaagagcccg actcgccgat gatctcaatg aaaaaattgc tctacgacca 60
gggccactgg agctggtgga aaaaaacatt cttcctgtgg attctgctgt gaaagaggcc 120
ataaaaggta accaggtgag tttctccaaa tccacggatg cttttgcctt tgaagaggac 180
agcagcagcg atgggctttc tccggatcag actcgaagtg aagaccccca aaactcagcg 240
ggatccccgc cagacgctaa agcctcagat accccttcga caggttctct ggggacaaac 300
caggatcttg cttctggctc agaaaatgac agaaatgact cagcctcaca gcccagccac 360
cagtcagatg cggggaagca ggggcttggc ccccccagca cccccatagc cgtgcatgct 420
gctgtaaagt ccaaatcctt gggtgacagt aagaaccgcc acaaaaagcc caaggacccc 480
aagccaaagg tgaagaagct taaatatcac cagtacattc ccccagacca gaaggcagag 540
aagtcccctc cacctatgga ctcagcctac gctcggctgc tccagcaaca gcagctgttc 600
ctgcagctcc aaatcctcag ccagcagcag cagcagcagc aacaccgatt cagctaccta 660
gggatgcacc aagctcagct taaggaacca aatgaacaga tggtcagaaa tccaaactct 720
tcttcaacgc cactgagcaa tacccccttg tctcctgtca aaaacagttt ttctggacaa 780
actggtgtct cttctttcaa accaggccca ctcccaccta acctggatga tctgaaggtc 840
tctgaattaa gacaacagct tcgaattcgg ggcttgcctg tgtcaggcac caaaacggct 900
ctcatggacc ggcttcgacc cttccaggac tgctctggca acccagtgcc gaactttggg 960
gatataacga ctgtcacttt tcctgtcaca cccaacacgc tgcccaatta ccagtcttcc 1020
tcttctacca gtgccctgtc caacggcttc taccactttg gcagcaccag ctccagcccc 1080
ccgatctccc cagcctcctc tgacctgtca gtcgctgggt ccctgccgga caccttcaat 1140
gatgcctccc cctccttcgg cctgcacccg tccccagtcc acgtgtgcac ggaggaaagt 1200
ctcatgagca gcctgaatgg gggctctgtt ccttctgagc tggatgggct ggactccgag 1260
aaggacaaga tgctggtgga gaagcagaag gtgatcaatg aactcacctg gaaactccag 1320
caagagcaga ggcaggtgga ggagctgagg atgcagcttc agaagcagaa aaggaataac 1380
tgttcagaga agaagccgct gcctttcctg gctgcctcca tcaagcagga agaggctgtc 1440
tccagctgtc cttttgcatc ccaagtacct gtgaaaagac aaagcagcag ctcagagtgt 1500
cacccaccgg cttgtgaagc tgctcaactc cagcctcttg gaaatgctca ttgtgtggag 1560
tcctcagatc aaaccaatgt actttcttcc acatttctca gcccccagtg ttcccctcag 1620
cattcaccgc tgggggctgt gaaaagccca cagcacatca gtttgccccc atcacccaac 1680
aaccctcact ttctgccctc atcctccggg gcccagggag aagggcacag ggtctcctcg 1740
cccatcagca gccaggtgtg cactgcacag aactcaggag cacacgatgg ccatcctcca 1800
agcttctctc cccattcttc cagcctccac ccgcccttct ctggagccca agcagacagc 1860
agtcatggtg ccgggggaaa cccttgtccc aaaagcccat gtgtacagca aaagatggct 1920
ggtttacact cttctgataa ggtggggcca aagttttcaa ttccatcccc aactttttct 1980
aagtcaagtt cagcaatttc agaggtaaca cagcctccat cctatgaaga tgccgtaaag 2040
caggtaacca tgtga                                                  2055

<210> 41
<211> 986
<212> PRT
<213> Homo sapiens

<400> 41
Met Thr Leu Leu Gly Ser Glu His Ser Leu Leu Ile Arg Ser Lys Phe
 1               5                  10                  15      
Arg Ser Val Leu Gln Leu Arg Leu Gln Gln Arg Arg Thr Gln Glu Gln
            20                  25                  30          
Leu Ala Asn Gln Gly Ile Ile Pro Pro Leu Lys Arg Pro Ala Glu Phe
        35                  40                  45              
His Glu Gln Arg Lys His Leu Asp Ser Asp Lys Ala Lys Asn Ser Leu
    50                  55                  60                  
Lys Arg Lys Ala Arg Asn Arg Cys Asn Ser Ala Asp Leu Val Asn Met
65                  70                  75                  80  
His Ile Leu Gln Ala Ser Thr Ala Glu Arg Ser Ile Pro Thr Ala Gln
                85                  90                  95      
Met Lys Leu Lys Arg Ala Arg Leu Ala Asp Asp Leu Asn Glu Lys Ile
            100                 105                 110         
Ala Leu Arg Pro Gly Pro Leu Glu Leu Val Glu Lys Asn Ile Leu Pro
        115                 120                 125             
Val Asp Ser Ala Val Lys Glu Ala Ile Lys Gly Asn Gln Val Ser Phe
    130                 135                 140                 
Ser Lys Ser Thr Asp Ala Phe Ala Phe Glu Glu Asp Ser Ser Ser Asp
145                 150                 155                 160 
Gly Leu Ser Pro Asp Gln Thr Arg Ser Glu Asp Pro Gln Asn Ser Ala
                165                 170                 175     
Gly Ser Pro Pro Asp Ala Lys Ala Ser Asp Thr Pro Ser Thr Gly Ser
            180                 185                 190         
Leu Gly Thr Asn Gln Asp Leu Ala Ser Gly Ser Glu Asn Asp Arg Asn
        195                 200                 205             
Asp Ser Ala Ser Gln Pro Ser His Gln Ser Asp Ala Gly Lys Gln Gly
    210                 215                 220                 
Leu Gly Pro Pro Ser Thr Pro Ile Ala Val His Ala Ala Val Lys Ser
225                 230                 235                 240 
Lys Ser Leu Gly Asp Ser Lys Asn Arg His Lys Lys Pro Lys Asp Pro
                245                 250                 255     
Lys Pro Lys Val Lys Lys Leu Lys Tyr His Gln Tyr Ile Pro Pro Asp
            260                 265                 270         
Gln Lys Ala Glu Lys Ser Pro Pro Pro Met Asp Ser Ala Tyr Ala Arg
        275                 280                 285             
Leu Leu Gln Gln Gln Gln Leu Phe Leu Gln Leu Gln Ile Leu Ser Gln
    290                 295                 300                 
Gln Gln Gln Gln Gln Gln His Arg Phe Ser Tyr Leu Gly Met His Gln
305                 310                 315                 320 
Ala Gln Leu Lys Glu Pro Asn Glu Gln Met Val Arg Asn Pro Asn Ser
                325                 330                 335     
Ser Ser Thr Pro Leu Ser Asn Thr Pro Leu Ser Pro Val Lys Asn Ser
            340                 345                 350         
Phe Ser Gly Gln Thr Gly Val Ser Ser Phe Lys Pro Gly Pro Leu Pro
        355                 360                 365             
Pro Asn Leu Asp Asp Leu Lys Val Ser Glu Leu Arg Gln Gln Leu Arg
    370                 375                 380                 
Ile Arg Gly Leu Pro Val Ser Gly Thr Lys Thr Ala Leu Met Asp Arg
385                 390                 395                 400 
Leu Arg Pro Phe Gln Asp Cys Ser Gly Asn Pro Val Pro Asn Phe Gly
                405                 410                 415     
Asp Ile Thr Thr Val Thr Phe Pro Val Thr Pro Asn Thr Leu Pro Asn
            420                 425                 430         
Tyr Gln Ser Ser Ser Ser Thr Ser Ala Leu Ser Asn Gly Phe Tyr His
        435                 440                 445             
Phe Gly Ser Thr Ser Ser Ser Pro Pro Ile Ser Pro Ala Ser Ser Asp
    450                 455                 460                 
Leu Ser Val Ala Gly Ser Leu Pro Asp Thr Phe Asn Asp Ala Ser Pro
465                 470                 475                 480 
Ser Phe Gly Leu His Pro Ser Pro Val His Val Cys Thr Glu Glu Ser
                485                 490                 495     
Leu Met Ser Ser Leu Asn Gly Gly Ser Val Pro Ser Glu Leu Asp Gly
            500                 505                 510         
Leu Asp Ser Glu Lys Asp Lys Met Leu Val Glu Lys Gln Lys Val Ile
        515                 520                 525             
Asn Glu Leu Thr Trp Lys Leu Gln Gln Glu Gln Arg Gln Val Glu Glu
    530                 535                 540                 
Leu Arg Met Gln Leu Gln Lys Gln Lys Arg Asn Asn Cys Ser Glu Lys
545                 550                 555                 560 
Lys Pro Leu Pro Phe Leu Ala Ala Ser Ile Lys Gln Glu Glu Ala Val
                565                 570                 575     
Ser Ser Cys Pro Phe Ala Ser Gln Val Pro Val Lys Arg Gln Ser Ser
            580                 585                 590         
Ser Ser Glu Cys His Pro Pro Ala Cys Glu Ala Ala Gln Leu Gln Pro
        595                 600                 605             
Leu Gly Asn Ala His Cys Val Glu Ser Ser Asp Gln Thr Asn Val Leu
    610                 615                 620                 
Ser Ser Thr Phe Leu Ser Pro Gln Cys Ser Pro Gln His Ser Pro Leu
625                 630                 635                 640 
Gly Ala Val Lys Ser Pro Gln His Ile Ser Leu Pro Pro Ser Pro Asn
                645                 650                 655     
Asn Pro His Phe Leu Pro Ser Ser Ser Gly Ala Gln Gly Glu Gly His
            660                 665                 670         
Arg Val Ser Ser Pro Ile Ser Ser Gln Val Cys Thr Ala Gln Asn Ser
        675                 680                 685             
Gly Ala His Asp Gly His Pro Pro Ser Phe Ser Pro His Ser Ser Ser
    690                 695                 700                 
Leu His Pro Pro Phe Ser Gly Ala Gln Ala Asp Ser Ser His Gly Ala
705                 710                 715                 720 
Gly Gly Asn Pro Cys Pro Lys Ser Pro Cys Val Gln Gln Lys Met Ala
                725                 730                 735     
Gly Leu His Ser Ser Asp Lys Val Gly Pro Lys Phe Ser Ile Pro Ser
            740                 745                 750         
Pro Thr Phe Ser Lys Ser Ser Ser Ala Ile Ser Glu Val Thr Gln Pro
        755                 760                 765             
Pro Ser Tyr Glu Asp Ala Val Lys Gln Gln Met Thr Arg Ser Gln Gln
    770                 775                 780                 
Met Asp Glu Leu Leu Asp Val Leu Ile Glu Ser Gly Glu Met Pro Ala
785                 790                 795                 800 
Asp Ala Arg Glu Asp His Ser Cys Leu Gln Lys Val Pro Lys Ile Pro
                805                 810                 815     
Arg Ser Ser Arg Ser Pro Thr Ala Val Leu Thr Lys Pro Ser Ala Ser
            820                 825                 830         
Phe Glu Gln Ala Ser Ser Gly Ser Gln Ile Pro Phe Asp Pro Tyr Ala
        835                 840                 845             
Thr Asp Ser Asp Glu His Leu Glu Val Leu Leu Asn Ser Gln Ser Pro
    850                 855                 860                 
Leu Gly Lys Met Ser Asp Val Thr Leu Leu Lys Ile Gly Ser Glu Glu
865                 870                 875                 880 
Pro His Phe Asp Gly Ile Met Asp Gly Phe Ser Gly Lys Ala Ala Glu
                885                 890                 895     
Asp Leu Phe Asn Ala His Glu Ile Leu Pro Gly Pro Leu Ser Pro Met
            900                 905                 910         
Gln Thr Gln Phe Ser Pro Ser Ser Val Asp Ser Asn Gly Leu Gln Leu
        915                 920                 925             
Ser Phe Thr Glu Ser Pro Trp Glu Thr Met Glu Trp Leu Asp Leu Thr
    930                 935                 940                 
Pro Pro Asn Ser Thr Pro Gly Phe Ser Ala Leu Thr Thr Ser Ser Pro
945                 950                 955                 960 
Ser Ile Phe Asn Ile Asp Phe Leu Asp Val Thr Asp Leu Asn Leu Asn
                965                 970                 975     
Ser Ser Met Asp Leu His Leu Gln Gln Trp
            980                 985     


<210> 42
<211> 2961
<212> DNA
<213> Homo sapiens

<400> 42
atgacactcc tggggtctga gcattccttg ctgattagga gcaagttcag atcagtttta 60
cagttaagac ttcaacaaag aaggacccag gaacaactgg ctaaccaagg cataatacca 120
ccactgaaac gtccagctga attccatgag caaagaaaac atttggatag tgacaaggct 180
aaaaattccc tgaagcgcaa agccagaaac aggtgcaaca gtgccgactt ggttaatatg 240
cacatactcc aagcttccac tgcagagagg tccattccaa ctgctcagat gaagctgaaa 300
agagcccgac tcgccgatga tctcaatgaa aaaattgctc tacgaccagg gccactggag 360
ctggtggaaa aaaacattct tcctgtggat tctgctgtga aagaggccat aaaaggtaac 420
caggtgagtt tctccaaatc cacggatgct tttgcctttg aagaggacag cagcagcgat 480
gggctttctc cggatcagac tcgaagtgaa gacccccaaa actcagcggg atccccgcca 540
gacgctaaag cctcagatac cccttcgaca ggttctctgg ggacaaacca ggatcttgct 600
tctggctcag aaaatgacag aaatgactca gcctcacagc ccagccacca gtcagatgcg 660
gggaagcagg ggcttggccc ccccagcacc cccatagccg tgcatgctgc tgtaaagtcc 720
aaatccttgg gtgacagtaa gaaccgccac aaaaagccca aggaccccaa gccaaaggtg 780
aagaagctta aatatcacca gtacattccc ccagaccaga aggcagagaa gtcccctcca 840
cctatggact cagcctacgc tcggctgctc cagcaacagc agctgttcct gcagctccaa 900
atcctcagcc agcagcagca gcagcagcaa caccgattca gctacctagg gatgcaccaa 960
gctcagctta aggaaccaaa tgaacagatg gtcagaaatc caaactcttc ttcaacgcca 1020
ctgagcaata cccccttgtc tcctgtcaaa aacagttttt ctggacaaac tggtgtctct 1080
tctttcaaac caggcccact cccacctaac ctggatgatc tgaaggtctc tgaattaaga 1140
caacagcttc gaattcgggg cttgcctgtg tcaggcacca aaacggctct catggaccgg 1200
cttcgaccct tccaggactg ctctggcaac ccagtgccga actttgggga tataacgact 1260
gtcacttttc ctgtcacacc caacacgctg cccaattacc agtcttcctc ttctaccagt 1320
gccctgtcca acggcttcta ccactttggc agcaccagct ccagcccccc gatctcccca 1380
gcctcctctg acctgtcagt cgctgggtcc ctgccggaca ccttcaatga tgcctccccc 1440
tccttcggcc tgcacccgtc cccagtccac gtgtgcacgg aggaaagtct catgagcagc 1500
ctgaatgggg gctctgttcc ttctgagctg gatgggctgg actccgagaa ggacaagatg 1560
ctggtggaga agcagaaggt gatcaatgaa ctcacctgga aactccagca agagcagagg 1620
caggtggagg agctgaggat gcagcttcag aagcagaaaa ggaataactg ttcagagaag 1680
aagccgctgc ctttcctggc tgcctccatc aagcaggaag aggctgtctc cagctgtcct 1740
tttgcatccc aagtacctgt gaaaagacaa agcagcagct cagagtgtca cccaccggct 1800
tgtgaagctg ctcaactcca gcctcttgga aatgctcatt gtgtggagtc ctcagatcaa 1860
accaatgtac tttcttccac atttctcagc ccccagtgtt cccctcagca ttcaccgctg 1920
ggggctgtga aaagcccaca gcacatcagt ttgcccccat cacccaacaa ccctcacttt 1980
ctgccctcat cctccggggc ccagggagaa gggcacaggg tctcctcgcc catcagcagc 2040
caggtgtgca ctgcacagaa ctcaggagca cacgatggcc atcctccaag cttctctccc 2100
cattcttcca gcctccaccc gcccttctct ggagcccaag cagacagcag tcatggtgcc 2160
gggggaaacc cttgtcccaa aagcccatgt gtacagcaaa agatggctgg tttacactct 2220
tctgataagg tggggccaaa gttttcaatt ccatccccaa ctttttctaa gtcaagttca 2280
gcaatttcag aggtaacaca gcctccatcc tatgaagatg ccgtaaagca gcaaatgacc 2340
cggagtcagc agatggatga actcctggac gtgcttattg aaagcggaga aatgccagca 2400
gacgctagag aggatcactc atgtcttcaa aaagtcccaa agatacccag atcttcccga 2460
agtccaactg ctgtcctcac caagccctcg gcttcctttg aacaagcctc ttcaggcagc 2520
cagatcccct ttgatcccta tgccaccgac agtgatgagc atcttgaagt cttattaaat 2580
tcccagagcc ccctaggaaa gatgagtgat gtcacccttc taaaaattgg gagcgaagag 2640
cctcactttg atgggataat ggatggattc tctgggaagg ctgcagaaga cctcttcaat 2700
gcacatgaga tcttgccagg ccccctctct ccaatgcaga cacagttttc accctcttct 2760
gtggacagca atgggctgca gttaagcttc actgaatctc cctgggaaac catggagtgg 2820
ctggacctca ctccgccaaa ttccacacca ggctttagcg ccctcaccac cagcagcccc 2880
agcatcttca acatcgattt cctggatgtc actgatctca atttgaattc ttccatggac 2940
cttcacttgc agcagtggta g                                           2961

<210> 43
<211> 938
<212> PRT
<213> Homo sapiens

<400> 43
Met Thr Leu Leu Gly Ser Glu His Ser Leu Leu Ile Arg Ser Lys Phe
 1               5                  10                  15      
Arg Ser Val Leu Gln Leu Arg Leu Gln Gln Arg Arg Thr Gln Glu Gln
            20                  25                  30          
Leu Ala Asn Gln Gly Ile Ile Pro Pro Leu Lys Arg Pro Ala Glu Phe
        35                  40                  45              
His Glu Gln Arg Lys His Leu Asp Ser Asp Lys Ala Lys Asn Ser Leu
    50                  55                  60                  
Lys Arg Lys Ala Arg Asn Arg Cys Asn Ser Ala Asp Leu Val Asn Met
65                  70                  75                  80  
His Ile Leu Gln Ala Ser Thr Ala Glu Arg Ser Ile Pro Thr Ala Gln
                85                  90                  95      
Met Lys Leu Lys Arg Ala Arg Leu Ala Asp Asp Leu Asn Glu Lys Ile
            100                 105                 110         
Ala Leu Arg Pro Gly Pro Leu Glu Leu Val Glu Lys Asn Ile Leu Pro
        115                 120                 125             
Val Asp Ser Ala Val Lys Glu Ala Ile Lys Gly Asn Gln Val Ser Phe
    130                 135                 140                 
Ser Lys Ser Thr Asp Ala Phe Ala Phe Glu Glu Asp Ser Ser Ser Asp
145                 150                 155                 160 
Gly Leu Ser Pro Asp Gln Thr Arg Ser Glu Asp Pro Gln Asn Ser Ala
                165                 170                 175     
Gly Ser Pro Pro Asp Ala Lys Ala Ser Asp Thr Pro Ser Thr Gly Ser
            180                 185                 190         
Leu Gly Thr Asn Gln Asp Leu Ala Ser Gly Ser Glu Asn Asp Arg Asn
        195                 200                 205             
Asp Ser Ala Ser Gln Pro Ser His Gln Ser Asp Ala Gly Lys Gln Gly
    210                 215                 220                 
Leu Gly Pro Pro Ser Thr Pro Ile Ala Val His Ala Ala Val Lys Ser
225                 230                 235                 240 
Lys Ser Leu Gly Asp Ser Lys Asn Arg His Lys Lys Pro Lys Asp Pro
                245                 250                 255     
Lys Pro Lys Val Lys Lys Leu Lys Tyr His Gln Tyr Ile Pro Pro Asp
            260                 265                 270         
Gln Lys Ala Glu Lys Ser Pro Pro Pro Met Asp Ser Ala Tyr Ala Arg
        275                 280                 285             
Leu Leu Gln Gln Gln Gln Leu Phe Leu Gln Leu Gln Ile Leu Ser Gln
    290                 295                 300                 
Gln Gln Gln Gln Gln Gln His Arg Phe Ser Tyr Leu Gly Met His Gln
305                 310                 315                 320 
Ala Gln Leu Lys Glu Pro Asn Glu Gln Met Val Arg Asn Pro Asn Ser
                325                 330                 335     
Ser Ser Thr Pro Leu Ser Asn Thr Pro Leu Ser Pro Val Lys Asn Ser
            340                 345                 350         
Phe Ser Gly Gln Thr Gly Val Ser Ser Phe Lys Pro Gly Pro Leu Pro
        355                 360                 365             
Pro Asn Leu Asp Asp Leu Lys Val Ser Glu Leu Arg Gln Gln Leu Arg
    370                 375                 380                 
Ile Arg Gly Leu Pro Val Ser Gly Thr Lys Thr Ala Leu Met Asp Arg
385                 390                 395                 400 
Leu Arg Pro Phe Gln Asp Cys Ser Gly Asn Pro Val Pro Asn Phe Gly
                405                 410                 415     
Asp Ile Thr Thr Val Thr Phe Pro Val Thr Pro Asn Thr Leu Pro Asn
            420                 425                 430         
Tyr Gln Ser Ser Ser Ser Thr Ser Ala Leu Ser Asn Gly Phe Tyr His
        435                 440                 445             
Phe Gly Ser Thr Ser Ser Ser Pro Pro Ile Ser Pro Ala Ser Ser Asp
    450                 455                 460                 
Leu Ser Val Ala Gly Ser Leu Pro Asp Thr Phe Asn Asp Ala Ser Pro
465                 470                 475                 480 
Ser Phe Gly Leu His Pro Ser Pro Val His Val Cys Thr Glu Glu Ser
                485                 490                 495     
Leu Met Ser Ser Leu Asn Gly Gly Ser Val Pro Ser Glu Leu Asp Gly
            500                 505                 510         
Leu Asp Ser Glu Lys Asp Lys Met Leu Val Glu Lys Gln Lys Val Ile
        515                 520                 525             
Asn Glu Leu Thr Trp Lys Leu Gln Gln Glu Gln Arg Gln Val Glu Glu
    530                 535                 540                 
Leu Arg Met Gln Leu Gln Lys Gln Lys Arg Asn Asn Cys Ser Glu Lys
545                 550                 555                 560 
Lys Pro Leu Pro Phe Leu Ala Ala Ser Ile Lys Gln Glu Glu Ala Val
                565                 570                 575     
Ser Ser Cys Pro Phe Ala Ser Gln Val Pro Val Lys Arg Gln Ser Ser
            580                 585                 590         
Ser Ser Glu Cys His Pro Pro Ala Cys Glu Ala Ala Gln Leu Gln Pro
        595                 600                 605             
Leu Gly Asn Ala His Cys Val Glu Ser Ser Asp Gln Thr Asn Val Leu
    610                 615                 620                 
Ser Ser Thr Phe Leu Ser Pro Gln Cys Ser Pro Gln His Ser Pro Leu
625                 630                 635                 640 
Gly Ala Val Lys Ser Pro Gln His Ile Ser Leu Pro Pro Ser Pro Asn
                645                 650                 655     
Asn Pro His Phe Leu Pro Ser Ser Ser Gly Ala Gln Gly Glu Gly His
            660                 665                 670         
Arg Val Ser Ser Pro Ile Ser Ser Gln Val Cys Thr Ala Gln Met Ala
        675                 680                 685             
Gly Leu His Ser Ser Asp Lys Val Gly Pro Lys Phe Ser Ile Pro Ser
    690                 695                 700                 
Pro Thr Phe Ser Lys Ser Ser Ser Ala Ile Ser Glu Val Thr Gln Pro
705                 710                 715                 720 
Pro Ser Tyr Glu Asp Ala Val Lys Gln Gln Met Thr Arg Ser Gln Gln
                725                 730                 735     
Met Asp Glu Leu Leu Asp Val Leu Ile Glu Ser Gly Glu Met Pro Ala
            740                 745                 750         
Asp Ala Arg Glu Asp His Ser Cys Leu Gln Lys Val Pro Lys Ile Pro
        755                 760                 765             
Arg Ser Ser Arg Ser Pro Thr Ala Val Leu Thr Lys Pro Ser Ala Ser
    770                 775                 780                 
Phe Glu Gln Ala Ser Ser Gly Ser Gln Ile Pro Phe Asp Pro Tyr Ala
785                 790                 795                 800 
Thr Asp Ser Asp Glu His Leu Glu Val Leu Leu Asn Ser Gln Ser Pro
                805                 810                 815     
Leu Gly Lys Met Ser Asp Val Thr Leu Leu Lys Ile Gly Ser Glu Glu
            820                 825                 830         
Pro His Phe Asp Gly Ile Met Asp Gly Phe Ser Gly Lys Ala Ala Glu
        835                 840                 845             
Asp Leu Phe Asn Ala His Glu Ile Leu Pro Gly Pro Leu Ser Pro Met
    850                 855                 860                 
Gln Thr Gln Phe Ser Pro Ser Ser Val Asp Ser Asn Gly Leu Gln Leu
865                 870                 875                 880 
Ser Phe Thr Glu Ser Pro Trp Glu Thr Met Glu Trp Leu Asp Leu Thr
                885                 890                 895     
Pro Pro Asn Ser Thr Pro Gly Phe Ser Ala Leu Thr Thr Ser Ser Pro
            900                 905                 910         
Ser Ile Phe Asn Ile Asp Phe Leu Asp Val Thr Asp Leu Asn Leu Asn
        915                 920                 925             
Ser Ser Met Asp Leu His Leu Gln Gln Trp
    930                 935             


<210> 44
<211> 2817
<212> DNA
<213> Homo sapiens

<400> 44
atgacactcc tggggtctga gcattccttg ctgattagga gcaagttcag atcagtttta 60
cagttaagac ttcaacaaag aaggacccag gaacaactgg ctaaccaagg cataatacca 120
ccactgaaac gtccagctga attccatgag caaagaaaac atttggatag tgacaaggct 180
aaaaattccc tgaagcgcaa agccagaaac aggtgcaaca gtgccgactt ggttaatatg 240
cacatactcc aagcttccac tgcagagagg tccattccaa ctgctcagat gaagctgaaa 300
agagcccgac tcgccgatga tctcaatgaa aaaattgctc tacgaccagg gccactggag 360
ctggtggaaa aaaacattct tcctgtggat tctgctgtga aagaggccat aaaaggtaac 420
caggtgagtt tctccaaatc cacggatgct tttgcctttg aagaggacag cagcagcgat 480
gggctttctc cggatcagac tcgaagtgaa gacccccaaa actcagcggg atccccgcca 540
gacgctaaag cctcagatac cccttcgaca ggttctctgg ggacaaacca ggatcttgct 600
tctggctcag aaaatgacag aaatgactca gcctcacagc ccagccacca gtcagatgcg 660
gggaagcagg ggcttggccc ccccagcacc cccatagccg tgcatgctgc tgtaaagtcc 720
aaatccttgg gtgacagtaa gaaccgccac aaaaagccca aggaccccaa gccaaaggtg 780
aagaagctta aatatcacca gtacattccc ccagaccaga aggcagagaa gtcccctcca 840
cctatggact cagcctacgc tcggctgctc cagcaacagc agctgttcct gcagctccaa 900
atcctcagcc agcagcagca gcagcagcaa caccgattca gctacctagg gatgcaccaa 960
gctcagctta aggaaccaaa tgaacagatg gtcagaaatc caaactcttc ttcaacgcca 1020
ctgagcaata cccccttgtc tcctgtcaaa aacagttttt ctggacaaac tggtgtctct 1080
tctttcaaac caggcccact cccacctaac ctggatgatc tgaaggtctc tgaattaaga 1140
caacagcttc gaattcgggg cttgcctgtg tcaggcacca aaacggctct catggaccgg 1200
cttcgaccct tccaggactg ctctggcaac ccagtgccga actttgggga tataacgact 1260
gtcacttttc ctgtcacacc caacacgctg cccaattacc agtcttcctc ttctaccagt 1320
gccctgtcca acggcttcta ccactttggc agcaccagct ccagcccccc gatctcccca 1380
gcctcctctg acctgtcagt cgctgggtcc ctgccggaca ccttcaatga tgcctccccc 1440
tccttcggcc tgcacccgtc cccagtccac gtgtgcacgg aggaaagtct catgagcagc 1500
ctgaatgggg gctctgttcc ttctgagctg gatgggctgg actccgagaa ggacaagatg 1560
ctggtggaga agcagaaggt gatcaatgaa ctcacctgga aactccagca agagcagagg 1620
caggtggagg agctgaggat gcagcttcag aagcagaaaa ggaataactg ttcagagaag 1680
aagccgctgc ctttcctggc tgcctccatc aagcaggaag aggctgtctc cagctgtcct 1740
tttgcatccc aagtacctgt gaaaagacaa agcagcagct cagagtgtca cccaccggct 1800
tgtgaagctg ctcaactcca gcctcttgga aatgctcatt gtgtggagtc ctcagatcaa 1860
accaatgtac tttcttccac atttctcagc ccccagtgtt cccctcagca ttcaccgctg 1920
ggggctgtga aaagcccaca gcacatcagt ttgcccccat cacccaacaa ccctcacttt 1980
ctgccctcat cctccggggc ccagggagaa gggcacaggg tctcctcgcc catcagcagc 2040
caggtgtgca ctgcacagat ggctggttta cactcttctg ataaggtggg gccaaagttt 2100
tcaattccat ccccaacttt ttctaagtca agttcagcaa tttcagaggt aacacagcct 2160
ccatcctatg aagatgccgt aaagcagcaa atgacccgga gtcagcagat ggatgaactc 2220
ctggacgtgc ttattgaaag cggagaaatg ccagcagacg ctagagagga tcactcatgt 2280
cttcaaaaag tcccaaagat acccagatct tcccgaagtc caactgctgt cctcaccaag 2340
ccctcggctt cctttgaaca agcctcttca ggcagccaga tcccctttga tccctatgcc 2400
accgacagtg atgagcatct tgaagtctta ttaaattccc agagccccct aggaaagatg 2460
agtgatgtca cccttctaaa aattgggagc gaagagcctc actttgatgg gataatggat 2520
ggattctctg ggaaggctgc agaagacctc ttcaatgcac atgagatctt gccaggcccc 2580
ctctctccaa tgcagacaca gttttcaccc tcttctgtgg acagcaatgg gctgcagtta 2640
agcttcactg aatctccctg ggaaaccatg gagtggctgg acctcactcc gccaaattcc 2700
acaccaggct ttagcgccct caccaccagc agccccagca tcttcaacat cgatttcctg 2760
gatgtcactg atctcaattt gaattcttcc atggaccttc acttgcagca gtggtag    2817

<210> 45
<211> 490
<212> PRT
<213> Homo sapiens

<400> 45
Met Thr Ile Gly Arg Met Glu Asn Val Glu Val Phe Thr Ala Glu Gly
 1               5                  10                  15      
Lys Gly Arg Gly Leu Lys Ala Thr Lys Glu Phe Trp Ala Ala Asp Ile
            20                  25                  30          
Ile Phe Ala Glu Arg Ala Tyr Ser Ala Val Val Phe Asp Ser Leu Val
        35                  40                  45              
Asn Phe Val Cys His Thr Cys Phe Lys Arg Gln Glu Lys Leu His Arg
    50                  55                  60                  
Cys Gly Gln Cys Lys Phe Ala His Tyr Cys Asp Arg Thr Cys Gln Lys
65                  70                  75                  80  
Asp Ala Trp Leu Asn His Lys Asn Glu Cys Ser Ala Ile Lys Arg Tyr
                85                  90                  95      
Gly Lys Val Pro Asn Glu Asn Ile Arg Leu Ala Ala Arg Ile Met Trp
            100                 105                 110         
Arg Val Glu Arg Glu Gly Thr Gly Leu Thr Glu Gly Cys Leu Val Ser
        115                 120                 125             
Val Asp Asp Leu Gln Asn His Val Glu His Phe Gly Glu Glu Glu Gln
    130                 135                 140                 
Lys Asp Leu Arg Val Asp Val Asp Thr Phe Leu Gln Tyr Trp Pro Pro
145                 150                 155                 160 
Gln Ser Gln Gln Phe Ser Met Gln Tyr Ile Ser His Ile Phe Gly Val
                165                 170                 175     
Ile Asn Cys Asn Gly Phe Thr Leu Ser Asp Gln Arg Gly Leu Gln Ala
            180                 185                 190         
Val Gly Val Gly Ile Phe Pro Asn Leu Gly Leu Val Asn His Asp Cys
        195                 200                 205             
Trp Pro Asn Cys Thr Val Ile Phe Asn Asn Gly Asn His Glu Ala Val
    210                 215                 220                 
Lys Ser Met Phe His Thr Gln Met Arg Ile Glu Leu Arg Ala Leu Gly
225                 230                 235                 240 
Lys Ile Ser Glu Gly Glu Glu Leu Thr Val Ser Tyr Ile Asp Phe Leu
                245                 250                 255     
Asn Val Ser Glu Glu Arg Lys Arg Gln Leu Lys Lys Gln Tyr Tyr Phe
            260                 265                 270         
Asp Cys Thr Cys Glu His Cys Gln Lys Lys Leu Lys Asp Asp Leu Phe
        275                 280                 285             
Leu Gly Val Lys Asp Asn Pro Lys Pro Ser Gln Glu Val Val Lys Glu
    290                 295                 300                 
Met Ile Gln Phe Ser Lys Asp Thr Leu Glu Lys Ile Asp Lys Ala Arg
305                 310                 315                 320 
Ser Glu Gly Leu Tyr His Glu Val Val Lys Leu Cys Arg Glu Cys Leu
                325                 330                 335     
Glu Lys Gln Glu Pro Val Phe Ala Asp Thr Asn Ile Tyr Met Leu Arg
            340                 345                 350         
Met Leu Ser Ile Val Ser Glu Val Leu Ser Tyr Leu Gln Ala Phe Glu
        355                 360                 365             
Glu Ala Ser Phe Tyr Ala Arg Arg Met Val Asp Gly Tyr Met Lys Leu
    370                 375                 380                 
Tyr His Pro Asn Asn Ala Gln Leu Gly Met Ala Val Met Arg Ala Gly
385                 390                 395                 400 
Leu Thr Asn Trp His Ala Gly Asn Ile Glu Val Gly His Gly Met Ile
                405                 410                 415     
Cys Lys Ala Tyr Ala Ile Leu Leu Val Thr His Gly Pro Ser His Pro
            420                 425                 430         
Ile Thr Lys Asp Leu Glu Ala Met Arg Val Gln Thr Glu Met Glu Leu
        435                 440                 445             
Arg Met Phe Arg Gln Asn Glu Phe Met Tyr Tyr Lys Met Arg Glu Ala
    450                 455                 460                 
Ala Leu Asn Asn Gln Pro Met Gln Val Met Ala Glu Pro Ser Asn Glu
465                 470                 475                 480 
Pro Ser Pro Ala Leu Phe His Lys Lys Gln
                485                 490 


<210> 46
<211> 1473
<212> DNA
<213> Homo sapiens

<400> 46
atgacaatag ggagaatgga gaacgtggag gtcttcaccg ctgagggcaa aggaaggggt 60
ctgaaggcca ccaaggagtt ctgggctgca gatatcatct ttgctgagcg ggcttattcc 120
gcagtggttt ttgacagcct tgttaatttt gtgtgccaca cctgcttcaa gaggcaggag 180
aagctccatc gctgtgggca gtgcaagttt gcccattact gcgaccgcac ctgccagaag 240
gatgcttggc tgaaccacaa gaatgaatgt tcggccatca agagatatgg gaaggtgccc 300
aatgagaaca tcaggctggc ggcgcgcatc atgtggcggg tggagagaga aggcaccggg 360
ctcacggagg gctgcctggt gtccgtggac gacttgcaga accacgtgga gcactttggg 420
gaggaggagc agaaggacct gcgggtggac gtggacacat tcttgcagta ctggccgccg 480
cagagccagc agttcagcat gcagtacatc tcgcacatct tcggagtgat taactgcaac 540
ggttttactc tcagtgatca gagaggcctg caggccgtgg gcgtaggcat cttccccaac 600
ctgggcctgg tgaaccatga ctgttggccc aactgtactg tcatatttaa caatggcaat 660
catgaggcag tgaaatccat gtttcatacc cagatgagaa ttgagctccg ggccctaggc 720
aagatctcag aaggagagga gctgactgtg tcctatattg acttcctcaa cgttagtgaa 780
gaacgcaaga ggcagctgaa gaagcagtac tactttgact gcacatgtga acactgccag 840
aaaaaactga aggatgacct cttcctgggg gtgaaagaca accccaagcc ctctcaggaa 900
gtggtgaagg agatgataca attctccaag gatacattgg aaaagataga caaggctcgt 960
tccgagggtt tgtatcatga ggttgtgaaa ttatgccggg agtgcctgga gaagcaggag 1020
ccagtgtttg ctgacaccaa catctacatg ctgcggatgc tgagcattgt ttcggaggtc 1080
ctttcctacc tccaggcctt tgaggaggcc tcgttctatg ccaggaggat ggtggacggc 1140
tatatgaagc tctaccaccc caacaatgcc caactgggca tggccgtgat gcgggcaggg 1200
ctgaccaact ggcatgctgg taacattgag gtggggcacg ggatgatctg caaagcctat 1260
gccattctcc tggtgacaca cggaccctcc caccccatca ctaaggactt agaggccatg 1320
cgggtgcaga cggagatgga gctacgcatg ttccgccaga acgaattcat gtactacaag 1380
atgcgcgagg ctgccctgaa caaccagccc atgcaggtca tggccgagcc cagcaatgag 1440
ccatccccag ctctgttcca caagaagcaa tga                              1473

<210> 47
<211> 508
<212> PRT
<213> Homo sapiens

<400> 47
Met Leu Pro Thr Gln Ala Gly Ala Ala Ala Ala Leu Gly Arg Gly Ser
 1               5                  10                  15      
Ala Leu Gly Gly Ser Leu Asn Arg Thr Pro Thr Gly Arg Pro Gly Gly
            20                  25                  30          
Gly Gly Gly Thr Arg Gly Ala Asn Gly Gly Arg Val Pro Gly Asn Gly
        35                  40                  45              
Ala Gly Leu Gly Pro Gly Arg Leu Glu Arg Glu Ala Ala Ala Ala Ala
    50                  55                  60                  
Ala Thr Thr Pro Ala Pro Thr Ala Gly Ala Leu Tyr Ser Gly Ser Glu
65                  70                  75                  80  
Gly Asp Ser Glu Ser Gly Glu Glu Glu Glu Leu Gly Ala Glu Arg Arg
                85                  90                  95      
Gly Leu Lys Arg Ser Leu Ser Glu Met Glu Ile Gly Met Val Val Gly
            100                 105                 110         
Gly Pro Glu Ala Ser Ala Ala Ala Thr Gly Gly Tyr Gly Pro Val Ser
        115                 120                 125             
Gly Ala Val Ser Gly Ala Lys Pro Gly Lys Lys Thr Arg Gly Arg Val
    130                 135                 140                 
Lys Ile Lys Met Glu Phe Ile Asp Asn Lys Leu Arg Arg Tyr Thr Thr
145                 150                 155                 160 
Phe Ser Lys Arg Lys Thr Gly Ile Met Lys Lys Ala Tyr Glu Leu Ser
                165                 170                 175     
Thr Leu Thr Gly Thr Gln Val Leu Leu Leu Val Ala Ser Glu Thr Gly
            180                 185                 190         
His Val Tyr Thr Phe Ala Thr Arg Lys Leu Gln Pro Met Ile Thr Ser
        195                 200                 205             
Glu Thr Gly Lys Ala Leu Ile Gln Thr Cys Leu Asn Ser Pro Asp Ser
    210                 215                 220                 
Pro Pro Arg Ser Asp Pro Thr Thr Asp Gln Arg Met Ser Ala Thr Gly
225                 230                 235                 240 
Phe Glu Glu Thr Asp Leu Thr Tyr Gln Val Ser Glu Ser Asp Ser Ser
                245                 250                 255     
Gly Glu Thr Lys Asp Thr Leu Lys Pro Ala Phe Thr Val Thr Asn Leu
            260                 265                 270         
Pro Gly Thr Thr Ser Thr Ile Gln Thr Ala Pro Ser Thr Ser Thr Thr
        275                 280                 285             
Met Gln Val Ser Ser Gly Pro Ser Phe Pro Ile Thr Asn Tyr Leu Ala
    290                 295                 300                 
Pro Val Ser Ala Ser Val Ser Pro Ser Ala Val Ser Ser Ala Asn Gly
305                 310                 315                 320 
Thr Val Leu Lys Ser Thr Gly Ser Gly Pro Val Ser Ser Gly Gly Leu
                325                 330                 335     
Met Gln Leu Pro Thr Ser Phe Thr Leu Met Pro Gly Gly Ala Val Ala
            340                 345                 350         
Gln Gln Val Pro Val Gln Ala Ile Gln Val His Gln Ala Pro Gln Gln
        355                 360                 365             
Ala Ser Pro Ser Arg Asp Ser Ser Thr Asp Leu Thr Gln Thr Ser Ser
    370                 375                 380                 
Ser Gly Thr Val Thr Leu Pro Ala Thr Ile Met Thr Ser Ser Val Pro
385                 390                 395                 400 
Thr Thr Val Gly Gly His Met Met Tyr Pro Ser Pro His Ala Val Met
                405                 410                 415     
Tyr Ala Pro Thr Ser Gly Leu Gly Asp Gly Ser Leu Thr Val Leu Asn
            420                 425                 430         
Ala Phe Ser Gln Ala Pro Ser Thr Met Gln Val Ser His Ser Gln Val
        435                 440                 445             
Gln Glu Pro Gly Gly Val Pro Gln Val Phe Leu Thr Ala Ser Ser Gly
    450                 455                 460                 
Thr Val Gln Ile Pro Val Ser Ala Val Gln Leu His Gln Met Ala Val
465                 470                 475                 480 
Ile Gly Gln Gln Ala Gly Ser Ser Ser Asn Leu Thr Glu Leu Gln Val
                485                 490                 495     
Val Asn Leu Asp Thr Ala His Ser Thr Lys Ser Glu
            500                 505             


<210> 48
<211> 1527
<212> DNA
<213> Homo sapiens

<400> 48
atgttaccga cccaagctgg ggccgcggcg gctctgggcc ggggctcggc cctggggggc 60
agcctgaacc ggaccccgac ggggcggccg ggcggcggcg gcgggacacg cggggctaac 120
gggggccggg tccccgggaa tggcgcgggg ctcgggcccg gccgcctgga gcgggaggct 180
gcggcagcgg cggcaaccac cccggcgccc accgcggggg ccctctacag cggcagcgag 240
ggcgactcgg agtcgggcga ggaggaggag ctgggcgccg agcggcgcgg cctgaagcgg 300
agcctgagcg agatggagat cggtatggtg gtcggtgggc ccgaggcgtc ggcagcggcc 360
accgggggct acgggccggt gagcggcgcg gtgagcgggg ccaagccggg taagaagacc 420
cggggccgcg tgaagatcaa gatggagttc atcgacaaca agctgcggcg ctacacgacc 480
ttcagcaaga ggaagacggg catcatgaag aaggcctatg agctgtccac gctgacaggg 540
acacaggtgc tgttgctggt ggccagtgag acaggccatg tgtatacctt tgccacccga 600
aaactgcagc ccatgatcac cagtgagacc ggcaaggcac tgattcagac ctgcctcaac 660
tcgccagact ctccaccccg ttcagacccc acaacagacc agagaatgag tgccactggc 720
tttgaagaga cagatctcac ctaccaggtg tcggagtctg acagcagtgg ggagaccaag 780
gacacactga agccggcgtt cacagtcacc aacctgccgg gtacaacctc caccatccaa 840
acagcaccta gcacctctac caccatgcaa gtcagcagcg gcccctcctt tcccatcacc 900
aactacctgg caccagtgtc tgctagtgtc agccccagtg ctgtcagcag tgccaatggg 960
actgtgctga agagtacagg cagcggccct gtctcctctg ggggccttat gcagctgcct 1020
accagcttca ccctcatgcc tggtggggca gtggcccagc aggtcccagt gcaggccatt 1080
caagtgcacc aggccccaca gcaagcgtct ccctcccgtg acagcagcac agacctcacg 1140
cagacctcct ccagcgggac agtgacgctg cccgccacca tcatgacgtc atccgtgccc 1200
acaactgtgg gtggccacat gatgtaccct agcccgcatg cggtgatgta tgcccccacc 1260
tcgggcctgg gtgatggcag cctcaccgtg ctgaatgcct tctcccaggc accatccacc 1320
atgcaggtgt cacacagcca ggtccaggag ccaggtggcg tcccccaggt gttcctgaca 1380
gcatcatctg ggacagtgca gatccctgtt tcagcagttc agctccacca gatggctgtg 1440
atagggcagc aggccgggag cagcagcaac ctcaccgagc tacaggtggt gaacctggac 1500
accgcccaca gcaccaagag tgaatga                                     1527
