                         SEQUENCE LISTING

<110>  New York University
 
<120>  METHOD OF TREATING CANCER BY INHIBITION OF PROTEIN KINASE-LIKE 
       ENDOPLASMIC RETICULUM PROTEIN KINASE

<130>  29527.0952

<150>  US 61/347,206
<151>  2010-05-21

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  278
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be M or L

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa can be A or T

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Xaa can be G or R

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Xaa can be S or T

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  Xaa can be I or L

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  Xaa can be E or D

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Xaa can be R or H

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa can be S or G

<220>
<221>  MISC_FEATURE
<222>  (169)..(169)
<223>  Xaa can be R or T

<220>
<221>  MISC_FEATURE
<222>  (189)..(189)
<223>  Xaa can be S or N

<220>
<221>  MISC_FEATURE
<222>  (213)..(213)
<223>  Xaa can be Q or L

<220>
<221>  MISC_FEATURE
<222>  (219)..(219)
<223>  Xaa can be T or I

<220>
<221>  MISC_FEATURE
<222>  (230)..(230)
<223>  Xaa can be P or L

<220>
<221>  MISC_FEATURE
<222>  (238)..(238)
<223>  Xaa can be Q or C

<220>
<221>  MISC_FEATURE
<222>  (240)..(240)
<223>  Xaa can be Y or H

<220>
<221>  MISC_FEATURE
<222>  (241)..(241)
<223>  Xaa can be V or M

<220>
<221>  MISC_FEATURE
<222>  (252)..(252)
<223>  Xaa can be M or T

<220>
<221>  MISC_FEATURE
<222>  (258)..(258)
<223>  Xaa can be I or T

<220>
<221>  MISC_FEATURE
<222>  (259)..(259)
<223>  Xaa can be N or D

<220>
<221>  MISC_FEATURE
<222>  (265)..(265)
<223>  Xaa can be V or I

<220>
<221>  MISC_FEATURE
<222>  (268)..(268)
<223>  Xaa can be D or N

<220>
<221>  MISC_FEATURE
<222>  (270)..(270)
<223>  Xaa can be D or E

<400>  1

Phe Glu Pro Ile Gln Cys Xaa Gly Arg Gly Gly Phe Gly Val Val Phe 
1               5                   10                  15      


Glu Ala Lys Asn Lys Val Asp Asp Cys Asn Tyr Ala Ile Lys Arg Ile 
            20                  25                  30          


Arg Leu Pro Asn Arg Glu Leu Ala Arg Glu Lys Val Met Arg Glu Val 
        35                  40                  45              


Lys Ala Leu Ala Lys Leu Glu His Pro Gly Ile Val Arg Tyr Phe Asn 
    50                  55                  60                  


Ala Trp Leu Glu Xaa Lys Val Tyr Leu Tyr Ile Gln Met Gln Leu Cys 
65                  70                  75                  80  


Arg Lys Glu Asn Leu Lys Asp Trp Met Asn Xaa Arg Cys Xaa Xaa Glu 
                85                  90                  95      


Xaa Arg Glu Xaa Xaa Val Cys Leu His Ile Phe Leu Gln Ile Ala Glu 
            100                 105                 110         


Ala Val Glu Phe Leu His Ser Lys Gly Leu Met His Arg Asp Leu Lys 
        115                 120                 125             


Pro Ser Asn Ile Phe Phe Thr Met Asp Asp Val Val Lys Val Gly Asp 
    130                 135                 140                 


Phe Gly Leu Val Thr Ala Met Asp Gln Asp Glu Glu Glu Gln Thr Val 
145                 150                 155                 160 


Leu Thr Pro Met Pro Ala Tyr Ala Xaa His Thr Gly Gln Val Gly Thr 
                165                 170                 175     


Lys Leu Tyr Met Ser Pro Glu Gln Ile His Gly Asn Xaa Tyr Ser His 
            180                 185                 190         


Lys Val Asp Ile Phe Ser Leu Gly Leu Ile Leu Phe Glu Leu Leu Tyr 
        195                 200                 205             


Pro Phe Ser Thr Xaa Met Glu Arg Val Arg Xaa Leu Thr Asp Val Arg 
    210                 215                 220                 


Asn Leu Lys Phe Pro Xaa Leu Phe Thr Gln Lys Tyr Pro Xaa Glu Xaa 
225                 230                 235                 240 


Xaa Met Val Gln Asp Met Leu Ser Pro Ser Pro Xaa Glu Arg Pro Glu 
                245                 250                 255     


Ala Xaa Xaa Ile Ile Glu Asn Ala Xaa Phe Glu Xaa Leu Xaa Phe Pro 
            260                 265                 270         


Gly Lys Thr Val Leu Arg 
        275             


<210>  2
<211>  278
<212>  PRT
<213>  Mus musculus

<400>  2

Phe Glu Pro Ile Gln Cys Met Gly Arg Gly Gly Phe Gly Val Val Phe 
1               5                   10                  15      


Glu Ala Lys Asn Lys Val Asp Asp Cys Asn Tyr Ala Ile Lys Arg Ile 
            20                  25                  30          


Arg Leu Pro Asn Arg Glu Leu Ala Arg Glu Lys Val Met Arg Glu Val 
        35                  40                  45              


Lys Ala Leu Ala Lys Leu Glu His Pro Gly Ile Val Arg Tyr Phe Asn 
    50                  55                  60                  


Ala Trp Leu Glu Thr Lys Val Tyr Leu Tyr Ile Gln Met Gln Leu Cys 
65                  70                  75                  80  


Arg Lys Glu Asn Leu Lys Asp Trp Met Asn Arg Arg Cys Ser Leu Glu 
                85                  90                  95      


Asp Arg Glu His Gly Val Cys Leu His Ile Phe Leu Gln Ile Ala Glu 
            100                 105                 110         


Ala Val Glu Phe Leu His Ser Lys Gly Leu Met His Arg Asp Leu Lys 
        115                 120                 125             


Pro Ser Asn Ile Phe Phe Thr Met Asp Asp Val Val Lys Val Gly Asp 
    130                 135                 140                 


Phe Gly Leu Val Thr Ala Met Asp Gln Asp Glu Glu Glu Gln Thr Val 
145                 150                 155                 160 


Leu Thr Pro Met Pro Ala Tyr Ala Thr His Thr Gly Gln Val Gly Thr 
                165                 170                 175     


Lys Leu Tyr Met Ser Pro Glu Gln Ile His Gly Asn Asn Tyr Ser His 
            180                 185                 190         


Lys Val Asp Ile Phe Ser Leu Gly Leu Ile Leu Phe Glu Leu Leu Tyr 
        195                 200                 205             


Pro Phe Ser Thr Leu Met Glu Arg Val Arg Ile Leu Thr Asp Val Arg 
    210                 215                 220                 


Asn Leu Lys Phe Pro Leu Leu Phe Thr Gln Lys Tyr Pro Gln Glu His 
225                 230                 235                 240 


Met Met Val Gln Asp Met Leu Ser Pro Ser Pro Thr Glu Arg Pro Glu 
                245                 250                 255     


Ala Thr Asp Ile Ile Glu Asn Ala Ile Phe Glu Asn Leu Glu Phe Pro 
            260                 265                 270         


Gly Lys Thr Val Leu Arg 
        275             


<210>  3
<211>  1114
<212>  PRT
<213>  Mus musculus

<400>  3

Met Glu Arg Ala Thr Arg Pro Gly Pro Arg Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Phe Leu Leu Leu Gly Cys Ala Ala Gly Ile Ser Ala Val Ala Pro Ala 
            20                  25                  30          


Arg Ser Leu Leu Ala Pro Ala Ser Glu Thr Val Phe Gly Leu Gly Ala 
        35                  40                  45              


Ala Ala Ala Pro Thr Ser Ala Ala Arg Val Pro Ala Val Ala Thr Ala 
    50                  55                  60                  


Glu Val Thr Val Glu Asp Ala Glu Ala Leu Pro Ala Ala Ala Gly Glu 
65                  70                  75                  80  


Pro Glu Ser Arg Ala Thr Glu Pro Asp Asp Asp Val Glu Leu Arg Pro 
                85                  90                  95      


Arg Gly Arg Ser Leu Val Ile Ile Ser Thr Leu Asp Gly Arg Ile Ala 
            100                 105                 110         


Ala Leu Asp Ala Glu Asn Asp Gly Lys Lys Gln Trp Asp Leu Asp Val 
        115                 120                 125             


Gly Ser Gly Ser Leu Val Ser Ser Ser Leu Ser Lys Pro Glu Val Phe 
    130                 135                 140                 


Gly Asn Lys Met Ile Ile Pro Ser Leu Asp Gly Asp Leu Phe Gln Trp 
145                 150                 155                 160 


Asp Arg Asp Arg Glu Ser Met Glu Ala Val Pro Phe Thr Val Glu Ser 
                165                 170                 175     


Leu Leu Glu Ser Ser Tyr Lys Phe Gly Asp Asp Val Val Leu Val Gly 
            180                 185                 190         


Gly Lys Ser Leu Ile Thr Tyr Gly Leu Ser Ala Tyr Ser Gly Lys Leu 
        195                 200                 205             


Arg Tyr Ile Cys Ser Ala Leu Gly Cys Arg Arg Trp Asp Ser Asp Glu 
    210                 215                 220                 


Met Glu Glu Glu Glu Asp Ile Leu Leu Leu Gln Arg Thr Gln Lys Thr 
225                 230                 235                 240 


Val Arg Ala Val Gly Pro Arg Ser Gly Ser Glu Lys Trp Asn Phe Ser 
                245                 250                 255     


Val Gly His Phe Glu Leu Arg Tyr Ile Pro Asp Met Glu Thr Arg Ala 
            260                 265                 270         


Gly Phe Ile Glu Ser Thr Phe Lys Pro Gly Gly Asn Lys Glu Asp Ser 
        275                 280                 285             


Lys Ile Ile Ser Asp Val Glu Glu Gln Glu Ala Thr Met Leu Asp Thr 
    290                 295                 300                 


Val Ile Lys Val Ser Val Ala Asp Trp Lys Val Met Ala Phe Ser Arg 
305                 310                 315                 320 


Lys Gly Gly Arg Leu Glu Trp Glu Tyr Gln Phe Cys Thr Pro Ile Ala 
                325                 330                 335     


Ser Ala Trp Leu Val Arg Asp Gly Lys Val Ile Pro Ile Ser Leu Phe 
            340                 345                 350         


Asp Asp Thr Ser Tyr Thr Ala Ser Glu Glu Ala Leu Gly Asp Glu Glu 
        355                 360                 365             


Asp Ile Val Glu Ala Ala Arg Gly Ala Thr Glu Asn Ser Val Tyr Leu 
    370                 375                 380                 


Gly Met Tyr Arg Gly Gln Leu Tyr Leu Gln Ser Ser Val Arg Val Ser 
385                 390                 395                 400 


Glu Lys Phe Pro Thr Ser Pro Lys Ala Leu Glu Ser Val Asn Gly Glu 
                405                 410                 415     


Asn Ala Ile Ile Pro Leu Pro Thr Ile Lys Trp Lys Pro Leu Ile His 
            420                 425                 430         


Ser Pro Ser Arg Thr Pro Val Leu Val Gly Ser Asp Glu Phe Asp Lys 
        435                 440                 445             


Cys Leu Ser Asn Asp Lys Tyr Ser His Glu Glu Tyr Ser Asn Gly Ala 
    450                 455                 460                 


Leu Ser Ile Leu Gln Tyr Pro Tyr Asp Asn Gly Tyr Tyr Leu Pro Tyr 
465                 470                 475                 480 


Tyr Lys Arg Glu Arg Asn Lys Arg Ser Thr Gln Ile Thr Val Arg Phe 
                485                 490                 495     


Leu Asp Ser Pro His Tyr Ser Lys Asn Ile Arg Lys Lys Asp Pro Ile 
            500                 505                 510         


Leu Leu Leu His Trp Trp Lys Glu Ile Phe Gly Thr Ile Leu Leu Cys 
        515                 520                 525             


Ile Val Ala Thr Thr Phe Ile Val Arg Arg Leu Phe His Pro Gln Pro 
    530                 535                 540                 


His Arg Gln Arg Lys Glu Ser Glu Thr Gln Cys Gln Thr Glu Ser Lys 
545                 550                 555                 560 


Tyr Asp Ser Val Ser Ala Asp Val Ser Asp Asn Ser Trp Asn Asp Met 
                565                 570                 575     


Lys Tyr Ser Gly Tyr Val Ser Arg Tyr Leu Thr Asp Phe Glu Pro Ile 
            580                 585                 590         


Gln Cys Met Gly Arg Gly Gly Phe Gly Val Val Phe Glu Ala Lys Asn 
        595                 600                 605             


Lys Val Asp Asp Cys Asn Tyr Ala Ile Lys Arg Ile Arg Leu Pro Asn 
    610                 615                 620                 


Arg Glu Leu Ala Arg Glu Lys Val Met Arg Glu Val Lys Ala Leu Ala 
625                 630                 635                 640 


Lys Leu Glu His Pro Gly Ile Val Arg Tyr Phe Asn Ala Trp Leu Glu 
                645                 650                 655     


Thr Pro Pro Glu Lys Trp Gln Glu Glu Met Asp Glu Ile Trp Leu Lys 
            660                 665                 670         


Asp Glu Ser Thr Asp Trp Pro Leu Ser Ser Pro Ser Pro Met Asp Ala 
        675                 680                 685             


Pro Ser Val Lys Ile Arg Arg Met Asp Pro Phe Ser Thr Lys Glu Gln 
    690                 695                 700                 


Ile Glu Val Ile Ala Pro Ser Pro Glu Arg Ser Arg Ser Phe Ser Val 
705                 710                 715                 720 


Gly Ile Ser Cys Gly Gln Thr Ser Ser Ser Glu Ser Gln Phe Ser Pro 
                725                 730                 735     


Leu Glu Phe Ser Gly Thr Asp Cys Gly Asp Asn Ser Asp Ser Ala Asp 
            740                 745                 750         


Ala Ala Tyr Asn Leu Gln Asp Ser Cys Leu Thr Asp Cys Glu Asp Val 
        755                 760                 765             


Glu Asp Gly Thr Val Asp Gly Asn Asp Glu Gly His Ser Phe Glu Leu 
    770                 775                 780                 


Cys Pro Ser Glu Ala Ser Pro Tyr Thr Arg Ser Arg Glu Gly Thr Ser 
785                 790                 795                 800 


Ser Ser Ile Val Phe Glu Asp Ser Gly Cys Gly Asn Ala Ser Ser Lys 
                805                 810                 815     


Glu Glu Pro Arg Gly Asn Arg Leu His Asp Gly Asn His Tyr Val Asn 
            820                 825                 830         


Lys Leu Thr Asp Leu Lys Cys Ser Ser Ser Arg Ser Ser Ser Glu Ala 
        835                 840                 845             


Thr Thr Leu Ser Thr Ser Pro Thr Arg Pro Thr Thr Leu Ser Leu Asp 
    850                 855                 860                 


Phe Thr Lys Asn Thr Val Gly Gln Leu Gln Pro Ser Ser Pro Lys Val 
865                 870                 875                 880 


Tyr Leu Tyr Ile Gln Met Gln Leu Cys Arg Lys Glu Asn Leu Lys Asp 
                885                 890                 895     


Trp Met Asn Arg Arg Cys Ser Leu Glu Asp Arg Glu His Gly Val Cys 
            900                 905                 910         


Leu His Ile Phe Leu Gln Ile Ala Glu Ala Val Glu Phe Leu His Ser 
        915                 920                 925             


Lys Gly Leu Met His Arg Asp Leu Lys Pro Ser Asn Ile Phe Phe Thr 
    930                 935                 940                 


Met Asp Asp Val Val Lys Val Gly Asp Phe Gly Leu Val Thr Ala Met 
945                 950                 955                 960 


Asp Gln Asp Glu Glu Glu Gln Thr Val Leu Thr Pro Met Pro Ala Tyr 
                965                 970                 975     


Ala Thr His Thr Gly Gln Val Gly Thr Lys Leu Tyr Met Ser Pro Glu 
            980                 985                 990         


Gln Ile His Gly Asn Asn Tyr Ser  His Lys Val Asp Ile  Phe Ser Leu 
        995                 1000                 1005             


Gly Leu  Ile Leu Phe Glu Leu  Leu Tyr Pro Phe Ser  Thr Gln Met 
    1010                 1015                 1020             


Glu Arg  Val Arg Ile Leu Thr  Asp Val Arg Asn Leu  Lys Phe Pro 
    1025                 1030                 1035             


Leu Leu  Phe Thr Gln Lys Tyr  Pro Gln Glu His Met  Met Val Gln 
    1040                 1045                 1050             


Asp Met  Leu Ser Pro Ser Pro  Thr Glu Arg Pro Glu  Ala Thr Asp 
    1055                 1060                 1065             


Ile Ile  Glu Asn Ala Ile Phe  Glu Asn Leu Glu Phe  Pro Gly Lys 
    1070                 1075                 1080             


Thr Val  Leu Arg Gln Arg Ser  Arg Ser Met Ser Ser  Ser Gly Thr 
    1085                 1090                 1095             


Lys His  Ser Arg Gln Pro Ser  Cys Ser Tyr Ser Pro  Leu Pro Gly 
    1100                 1105                 1110             


Asn 
    


<210>  4
<211>  1115
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Arg Ala Ile Ser Pro Gly Leu Leu Val Arg Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Ala Ala Arg Thr Val Ala Ala Gly Arg Ala 
            20                  25                  30          


Arg Gly Leu Pro Ala Pro Thr Ala Glu Ala Ala Phe Gly Leu Gly Ala 
        35                  40                  45              


Ala Ala Ala Pro Thr Ser Ala Thr Arg Val Pro Ala Ala Gly Ala Val 
    50                  55                  60                  


Ala Ala Ala Glu Val Thr Val Glu Asp Ala Glu Ala Leu Pro Ala Ala 
65                  70                  75                  80  


Ala Gly Glu Gln Glu Pro Arg Gly Pro Glu Pro Asp Asp Glu Thr Glu 
                85                  90                  95      


Leu Arg Pro Arg Gly Arg Ser Leu Val Ile Ile Ser Thr Leu Asp Gly 
            100                 105                 110         


Arg Ile Ala Ala Leu Asp Pro Glu Asn His Gly Lys Lys Gln Trp Asp 
        115                 120                 125             


Leu Asp Val Gly Ser Gly Ser Leu Val Ser Ser Ser Leu Ser Lys Pro 
    130                 135                 140                 


Glu Val Phe Gly Asn Lys Met Ile Ile Pro Ser Leu Asp Gly Ala Leu 
145                 150                 155                 160 


Phe Gln Trp Asp Arg Asp Arg Glu Ser Met Glu Thr Val Pro Phe Thr 
                165                 170                 175     


Val Glu Ser Leu Leu Glu Ser Ser Tyr Lys Phe Gly Asp Asp Val Val 
            180                 185                 190         


Leu Val Gly Gly Lys Ser Leu Thr Thr Tyr Gly Leu Ser Ala Tyr Ser 
        195                 200                 205             


Gly Lys Val Arg Tyr Ile Cys Ser Ala Leu Gly Cys Arg Gln Trp Asp 
    210                 215                 220                 


Ser Asp Glu Met Glu Gln Glu Glu Asp Ile Leu Leu Leu Gln Arg Thr 
225                 230                 235                 240 


Gln Lys Thr Val Arg Ala Val Gly Pro Arg Ser Gly Asn Glu Lys Trp 
                245                 250                 255     


Asn Phe Ser Val Gly His Phe Glu Leu Arg Tyr Ile Pro Asp Met Glu 
            260                 265                 270         


Thr Arg Ala Gly Phe Ile Glu Ser Thr Phe Lys Pro Asn Glu Asn Thr 
        275                 280                 285             


Glu Glu Ser Lys Ile Ile Ser Asp Val Glu Glu Gln Glu Ala Ala Ile 
    290                 295                 300                 


Met Asp Ile Val Ile Lys Val Ser Val Ala Asp Trp Lys Val Met Ala 
305                 310                 315                 320 


Phe Ser Lys Lys Gly Gly His Leu Glu Trp Glu Tyr Gln Phe Cys Thr 
                325                 330                 335     


Pro Ile Ala Ser Ala Trp Leu Leu Lys Asp Gly Lys Val Ile Pro Ile 
            340                 345                 350         


Ser Leu Phe Asp Asp Thr Ser Tyr Thr Ser Asn Asp Asp Val Leu Glu 
        355                 360                 365             


Asp Glu Glu Asp Ile Val Glu Ala Ala Arg Gly Ala Thr Glu Asn Ser 
    370                 375                 380                 


Val Tyr Leu Gly Met Tyr Arg Gly Gln Leu Tyr Leu Gln Ser Ser Val 
385                 390                 395                 400 


Arg Ile Ser Glu Lys Phe Pro Ser Ser Pro Lys Ala Leu Glu Ser Val 
                405                 410                 415     


Thr Asn Glu Asn Ala Ile Ile Pro Leu Pro Thr Ile Lys Trp Lys Pro 
            420                 425                 430         


Leu Ile His Ser Pro Ser Arg Thr Pro Val Leu Val Gly Ser Asp Glu 
        435                 440                 445             


Phe Asp Lys Cys Leu Ser Asn Asp Lys Phe Ser His Glu Glu Tyr Ser 
    450                 455                 460                 


Asn Gly Ala Leu Ser Ile Leu Gln Tyr Pro Tyr Asp Asn Gly Tyr Tyr 
465                 470                 475                 480 


Leu Pro Tyr Tyr Lys Arg Glu Arg His Lys Arg Ser Thr Gln Ile Thr 
                485                 490                 495     


Val Arg Phe Leu Asp Asn Pro His Tyr Asn Lys Asn Ile Arg Lys Lys 
            500                 505                 510         


Asp Pro Val Leu Leu Leu His Trp Trp Lys Glu Ile Val Ala Thr Ile 
        515                 520                 525             


Leu Phe Cys Ile Ile Ala Thr Thr Phe Ile Val Arg Arg Leu Phe His 
    530                 535                 540                 


Pro His Pro His Arg Gln Arg Lys Glu Ser Glu Thr Gln Cys Gln Thr 
545                 550                 555                 560 


Glu Asn Lys Tyr Asp Ser Val Ser Gly Glu Ala Asn Asp Ser Ser Trp 
                565                 570                 575     


Asn Asp Ile Lys Asn Ser Gly Tyr Ile Ser Arg Tyr Leu Thr Asp Phe 
            580                 585                 590         


Glu Pro Ile Gln Cys Leu Gly Arg Gly Gly Phe Gly Val Val Phe Glu 
        595                 600                 605             


Ala Lys Asn Lys Val Asp Asp Cys Asn Tyr Ala Ile Lys Arg Ile Arg 
    610                 615                 620                 


Leu Pro Asn Arg Glu Leu Ala Arg Glu Lys Val Met Arg Glu Val Lys 
625                 630                 635                 640 


Ala Leu Ala Lys Leu Glu His Pro Gly Ile Val Arg Tyr Phe Asn Ala 
                645                 650                 655     


Trp Leu Glu Ala Pro Pro Glu Lys Trp Gln Glu Lys Met Asp Glu Ile 
            660                 665                 670         


Trp Leu Lys Asp Glu Ser Thr Asp Trp Pro Leu Ser Ser Pro Ser Pro 
        675                 680                 685             


Met Asp Ala Pro Ser Val Lys Ile Arg Arg Met Asp Pro Phe Ser Thr 
    690                 695                 700                 


Lys Glu His Ile Glu Ile Ile Ala Pro Ser Pro Gln Arg Ser Arg Ser 
705                 710                 715                 720 


Phe Ser Val Gly Ile Ser Cys Asp Gln Thr Ser Ser Ser Glu Ser Gln 
                725                 730                 735     


Phe Ser Pro Leu Glu Phe Ser Gly Met Asp His Glu Asp Ile Ser Glu 
            740                 745                 750         


Ser Val Asp Ala Ala Tyr Asn Leu Gln Asp Ser Cys Leu Thr Asp Cys 
        755                 760                 765             


Asp Val Glu Asp Gly Thr Met Asp Gly Asn Asp Glu Gly His Ser Phe 
    770                 775                 780                 


Glu Leu Cys Pro Ser Glu Ala Ser Pro Tyr Val Arg Ser Arg Glu Arg 
785                 790                 795                 800 


Thr Ser Ser Ser Ile Val Phe Glu Asp Ser Gly Cys Asp Asn Ala Ser 
                805                 810                 815     


Ser Lys Glu Glu Pro Lys Thr Asn Arg Leu His Ile Gly Asn His Cys 
            820                 825                 830         


Ala Asn Lys Leu Thr Ala Phe Lys Pro Thr Ser Ser Lys Ser Ser Ser 
        835                 840                 845             


Glu Ala Thr Leu Ser Ile Ser Pro Pro Arg Pro Thr Thr Leu Ser Leu 
    850                 855                 860                 


Asp Leu Thr Lys Asn Thr Thr Glu Lys Leu Gln Pro Ser Ser Pro Lys 
865                 870                 875                 880 


Val Tyr Leu Tyr Ile Gln Met Gln Leu Cys Arg Lys Glu Asn Leu Lys 
                885                 890                 895     


Asp Trp Met Asn Gly Arg Cys Thr Ile Glu Glu Arg Glu Arg Ser Val 
            900                 905                 910         


Cys Leu His Ile Phe Leu Gln Ile Ala Glu Ala Val Glu Phe Leu His 
        915                 920                 925             


Ser Lys Gly Leu Met His Arg Asp Leu Lys Pro Ser Asn Ile Phe Phe 
    930                 935                 940                 


Thr Met Asp Asp Val Val Lys Val Gly Asp Phe Gly Leu Val Thr Ala 
945                 950                 955                 960 


Met Asp Gln Asp Glu Glu Glu Gln Thr Val Leu Thr Pro Met Pro Ala 
                965                 970                 975     


Tyr Ala Arg His Thr Gly Gln Val Gly Thr Lys Leu Tyr Met Ser Pro 
            980                 985                 990         


Glu Gln Ile His Gly Asn Ser Tyr  Ser His Lys Val Asp  Ile Phe Ser 
        995                 1000                 1005             


Leu Gly  Leu Ile Leu Phe Glu  Leu Leu Tyr Pro Phe  Ser Thr Gln 
    1010                 1015                 1020             


Met Glu  Arg Val Arg Thr Leu  Thr Asp Val Arg Asn  Leu Lys Phe 
    1025                 1030                 1035             


Pro Pro  Leu Phe Thr Gln Lys  Tyr Pro Cys Glu Tyr  Val Met Val 
    1040                 1045                 1050             


Gln Asp  Met Leu Ser Pro Ser  Pro Met Glu Arg Pro  Glu Ala Ile 
    1055                 1060                 1065             


Asn Ile  Ile Glu Asn Ala Val  Phe Glu Asp Leu Asp  Phe Pro Gly 
    1070                 1075                 1080             


Lys Thr  Val Leu Arg Gln Arg  Ser Arg Ser Leu Ser  Ser Ser Gly 
    1085                 1090                 1095             


Thr Lys  His Ser Arg Gln Ser  Asn Asn Ser His Ser  Pro Leu Pro 
    1100                 1105                 1110             


Ser Asn  
    1115 


