                         SEQUENCE LISTING

<110>  Genmab A/S
 
<120>  Monoclonal antibodies against HER2 epitope

<130>  P/63.WO

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  1

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe His Phe Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Arg Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Thr Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Arg Gly Asp Tyr Tyr Tyr Phe Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  2
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  2

Gly Tyr Ser Phe His Phe Tyr Trp 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  3

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  4
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  4

Ala Arg Gln Arg Gly Asp Tyr Tyr Tyr Phe Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  5
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  5

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  6
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  6

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  7
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  7

Gln Gln Tyr Gly Ser Ser Leu Thr 
1               5               


<210>  8
<211>  119
<212>  PRT
<213>  homo sapiens

<400>  8

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Leu Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Arg Gly Gly Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Arg Ile Trp Gly Pro Leu Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  9
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  9

Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  10

Ile Arg Gly Gly Ala Gly Ser Thr 
1               5               


<210>  11
<211>  12
<212>  PRT
<213>  homo sapiens

<400>  11

Ala Lys Ala Arg Ile Trp Gly Pro Leu Phe Asp Tyr 
1               5                   10          


<210>  12
<211>  108
<212>  PRT
<213>  homo sapiens

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  13
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  13

Gln Ser Val Ser Ser Tyr 
1               5       


<210>  14
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  14

Gln Gln Arg Ser Asn Trp Pro Pro Leu Thr 
1               5                   10  


<210>  15
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Lys Thr Tyr Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Leu Leu Trp Phe Glu Glu Leu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  16
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  16

Gly Tyr Thr Phe Thr Arg Tyr Gly 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  17

Ile Ser Ala Tyr Asn Gly Lys Thr 
1               5               


<210>  18
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  18

Ala Arg Ser Pro Leu Leu Trp Phe Glu Glu Leu Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  19
<211>  108
<212>  PRT
<213>  homo sapiens

<400>  19

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Leu 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  20
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  20

Gln Ser Val Ser Ser Thr Tyr 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  21

Gln Gln Tyr Gly Thr Ser Leu Phe Thr 
1               5                   


<210>  22
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  22

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Arg Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Asn Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ala Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ala Gly Asp Phe Tyr Tyr Phe Asp Gly Leu Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  23
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  23

Gly Tyr Arg Phe Thr Thr Ser Tyr Trp 
1               5                   


<210>  24
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  24

Ile Tyr Pro Gly Asp Ser Tyr Thr 
1               5               


<210>  25
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  25

Ala Arg His Ala Gly Asp Phe Tyr Tyr Phe Asp Gly Leu Asp Val 
1               5                   10                  15  


<210>  26
<211>  109
<212>  PRT
<213>  homo sapiens

<400>  26

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 


<210>  27
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  27

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  28
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  28

Gln Gln Tyr Gly Ser Ser Pro Pro Ile Thr 
1               5                   10  


<210>  29
<211>  124
<212>  PRT
<213>  homo sapiens

<400>  29

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Arg Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Asp Arg Gly Phe Asp Tyr Tyr Ser Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  30
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  30

Gly Tyr Ser Phe Thr Arg Tyr Trp 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  31

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  32
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  32

Ala Arg Leu Thr Gly Asp Arg Gly Phe Asp Tyr Tyr Ser Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  33
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  33

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  34
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  34

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  35
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  35

Gln Gln Tyr Gly Ser Ser Phe Thr 
1               5               


<210>  36
<211>  119
<212>  PRT
<213>  homo sapiens

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Pro Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Glu Tyr Ser Ser Asn Trp Tyr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  37
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  37

Gly Gly Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  38

Ile Ile Pro Ile Leu Gly Ile Ala 
1               5               


<210>  39
<211>  12
<212>  PRT
<213>  homo sapiens

<400>  39

Ala Arg Asp Gln Glu Tyr Ser Ser Asn Trp Tyr Tyr 
1               5                   10          


<210>  40
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  40

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Leu Tyr Gly Ser Ser Pro 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  41
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  41

Gln Ser Val Arg Ser Ser Tyr 
1               5           


<210>  42
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  42

Gln Leu Tyr Gly Ser Ser Pro Thr 
1               5               


<210>  43
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  43

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Tyr Pro Gly Asp Ser His Thr Arg Tyr Arg Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Lys Gly Asp Phe Tyr Tyr Phe Phe Gly Leu Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Ala Ile Thr Val Ser Ser 
        115                 120         


<210>  44
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  44

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  45
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  45

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Tyr Pro Gly Asp Ser His Thr Arg Tyr Arg Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Ala Gly Asp Tyr Tyr Tyr Tyr Asn Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  46
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  46

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  47
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  47

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Lys Gly Asp Tyr Tyr Tyr His Tyr Gly Leu Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  48
<211>  109
<212>  PRT
<213>  homo sapiens

<400>  48

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  49
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  49

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Lys Gly Asp Tyr Tyr Tyr Phe Asn Gly Leu Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  50
<211>  109
<212>  PRT
<213>  homo sapiens

<400>  50

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  51
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  51

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Gly Ser Gly Tyr Arg Phe Ile Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Arg Gly Asp Tyr Tyr Tyr Phe Asn Gly Leu Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  52
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  52

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  53
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  53

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Arg Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Arg Gly Asp Tyr Tyr Tyr Phe Phe Gly Leu Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Leu 
        115                 120         


<210>  54
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  54

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  55
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  55

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Arg Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Phe Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Ala Gly Asp Tyr Tyr Tyr Tyr Asn Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  56
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  56

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  57
<211>  8
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ser or Arg

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ser, Thr, His or Ile

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ser, Arg or Phe

<400>  57

Gly Tyr Xaa Phe Xaa Xaa Tyr Trp 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Tyr

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Asp, Tyr or His

<400>  58

Ile Xaa Pro Gly Asp Ser Xaa Thr 
1               5               


<210>  59
<211>  17
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Gln, His or Leu

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Arg, Ala, Thr or Lys

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Gly

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Asp

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Arg or none

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Gly or none

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Tyr or Phe

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Asp

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Tyr, Phe or His

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Tyr, Asp, Ser, Phe or Asn

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Met or Leu

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Val or Ile

<400>  59

Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Gly Xaa Asp 
1               5                   10                  15      


Xaa 
    


<210>  60
<211>  8
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Asn or Ser

<400>  60

Gly Phe Thr Phe Ser Xaa Tyr Ala 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Arg or Ser

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ala or Gly

<400>  61

Ile Xaa Gly Xaa Xaa Gly Ser Thr 
1               5               


<210>  62
<211>  11
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Leu or Tyr

<400>  62

Ala Lys Arg Ile Trp Gly Pro Xaa Phe Asp Tyr 
1               5                   10      


<210>  63
<211>  8
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Arg or Ser

<400>  63

Gly Tyr Thr Phe Thr Xaa Tyr Gly 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Asn

<400>  64

Ile Ser Ala Tyr Asn Gly Xaa Thr 
1               5               


<210>  65
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  65

Ala Arg Ser Pro Leu Leu Trp Phe Glu Glu Leu Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  66
<211>  8
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Gly or Ala

<400>  66

Gly Gly Thr Phe Ser Ser Tyr Xaa 
1               5               


<210>  67
<211>  11
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Asn or Tyr

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Trp or Phe

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Tyr or Asp

<400>  67

Ala Arg Asp Gln Glu Tyr Ser Ser Xaa Xaa Xaa 
1               5                   10      


<210>  68
<211>  7
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Ser or Arg

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ser or Thr

<400>  68

Gln Ser Val Xaa Ser Xaa Tyr 
1               5           


<210>  69
<211>  10
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Gln or Leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Pro or none

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Pro, Leu, Arg or none

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Leu, Phe, Ile or none

<400>  69

Gln Xaa Tyr Gly Xaa Ser Xaa Xaa Xaa Thr 
1               5                   10  


