                         SEQUENCE LISTING

<110>  Board of Supervisors of Louisiana State University and 
       Agricultural and Mechanical College
       Newcomer, Marcia E.
       Bartlett, Sue G.
       Gilbert, Nathaniel C.
 
<120>  A Soluble and Stable Human 5-Lipoxygenase

<130>  Newcomer 1014W

<140>  PCT/US2011/______
<141>  2011-05-30

<150>  61/350,197
<151>  2010-06-01

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  673
<212>  PRT
<213>  Human 5-LOX

<400>  1

Pro Ser Tyr Thr Val Thr Val Ala Thr Gly Ser Gln Trp Phe Ala Gly 
1               5                   10                  15      


Thr Asp Asp Tyr Ile Tyr Leu Ser Leu Val Gly Ser Ala Gly Cys Ser 
            20                  25                  30          


Glu Lys His Leu Leu Asp Lys Pro Phe Tyr Asn Asp Phe Glu Arg Gly 
        35                  40                  45              


Ala Val Asp Ser Tyr Asp Val Thr Val Asp Glu Glu Leu Gly Glu Ile 
    50                  55                  60                  


Gln Leu Val Arg Ile Glu Lys Arg Lys Tyr Trp Leu Asn Asp Asp Trp 
65                  70                  75                  80  


Tyr Leu Lys Tyr Ile Thr Leu Lys Thr Pro His Gly Asp Tyr Ile Glu 
                85                  90                  95      


Phe Pro Cys Tyr Arg Trp Ile Thr Gly Asp Val Glu Val Val Leu Arg 
            100                 105                 110         


Asp Gly Arg Ala Lys Leu Ala Arg Asp Asp Gln Ile His Ile Leu Lys 
        115                 120                 125             


Gln His Arg Arg Lys Glu Leu Glu Thr Arg Gln Lys Gln Tyr Arg Trp 
    130                 135                 140                 


Met Glu Trp Asn Pro Gly Phe Pro Leu Ser Ile Asp Ala Lys Cys His 
145                 150                 155                 160 


Lys Asp Leu Pro Arg Asp Ile Gln Phe Asp Ser Glu Lys Gly Val Asp 
                165                 170                 175     


Phe Val Leu Asn Tyr Ser Lys Ala Met Glu Asn Leu Phe Ile Asn Arg 
            180                 185                 190         


Phe Met His Met Phe Gln Ser Ser Trp Asn Asp Phe Ala Asp Phe Glu 
        195                 200                 205             


Lys Ile Phe Val Lys Ile Ser Asn Thr Ile Ser Glu Arg Val Met Asn 
    210                 215                 220                 


His Trp Gln Glu Asp Leu Met Phe Gly Tyr Gln Phe Leu Asn Gly Cys 
225                 230                 235                 240 


Asn Pro Val Leu Ile Arg Arg Cys Thr Glu Leu Pro Glu Lys Leu Pro 
                245                 250                 255     


Val Thr Thr Glu Met Val Glu Cys Ser Leu Glu Arg Gln Leu Ser Leu 
            260                 265                 270         


Glu Gln Glu Val Gln Gln Gly Asn Ile Phe Ile Val Asp Phe Glu Leu 
        275                 280                 285             


Leu Asp Gly Ile Asp Ala Asn Lys Thr Asp Pro Cys Thr Leu Gln Phe 
    290                 295                 300                 


Leu Ala Ala Pro Ile Cys Leu Leu Tyr Lys Asn Leu Ala Asn Lys Ile 
305                 310                 315                 320 


Val Pro Ile Ala Ile Gln Leu Asn Gln Ile Pro Gly Asp Glu Asn Pro 
                325                 330                 335     


Ile Phe Leu Pro Ser Asp Ala Lys Tyr Asp Trp Leu Leu Ala Lys Ile 
            340                 345                 350         


Trp Val Arg Ser Ser Asp Phe His Val His Gln Thr Ile Thr His Leu 
        355                 360                 365             


Leu Arg Thr His Leu Val Ser Glu Val Phe Gly Ile Ala Met Tyr Arg 
    370                 375                 380                 


Gln Leu Pro Ala Val His Pro Ile Phe Lys Leu Leu Val Ala His Val 
385                 390                 395                 400 


Arg Phe Thr Ile Ala Ile Asn Thr Lys Ala Arg Glu Gln Leu Ile Cys 
                405                 410                 415     


Glu Cys Gly Leu Phe Asp Lys Ala Asn Ala Thr Gly Gly Gly Gly His 
            420                 425                 430         


Val Gln Met Val Gln Arg Ala Met Lys Asp Leu Thr Tyr Ala Ser Leu 
        435                 440                 445             


Cys Phe Pro Glu Ala Ile Lys Ala Arg Gly Met Glu Ser Lys Glu Asp 
    450                 455                 460                 


Ile Pro Tyr Tyr Phe Tyr Arg Asp Asp Gly Leu Leu Val Trp Glu Ala 
465                 470                 475                 480 


Ile Arg Thr Phe Thr Ala Glu Val Val Asp Ile Tyr Tyr Glu Gly Asp 
                485                 490                 495     


Gln Val Val Glu Glu Asp Pro Glu Leu Gln Asp Phe Val Asn Asp Val 
            500                 505                 510         


Tyr Val Tyr Gly Met Arg Gly Arg Lys Ser Ser Gly Phe Pro Lys Ser 
        515                 520                 525             


Val Lys Ser Arg Glu Gln Leu Ser Glu Tyr Leu Thr Val Val Ile Phe 
    530                 535                 540                 


Thr Ala Ser Ala Gln His Ala Ala Val Asn Phe Gly Gln Tyr Asp Trp 
545                 550                 555                 560 


Cys Ser Trp Ile Pro Asn Ala Pro Pro Thr Met Arg Ala Pro Pro Pro 
                565                 570                 575     


Thr Ala Lys Gly Val Val Thr Ile Glu Gln Ile Val Asp Thr Leu Pro 
            580                 585                 590         


Asp Arg Gly Arg Ser Cys Trp His Leu Gly Ala Val Trp Ala Leu Ser 
        595                 600                 605             


Gln Phe Gln Glu Asn Glu Leu Phe Leu Gly Met Tyr Pro Glu Glu His 
    610                 615                 620                 


Phe Ile Glu Lys Pro Val Lys Glu Ala Met Ala Arg Phe Arg Lys Asn 
625                 630                 635                 640 


Leu Glu Ala Ile Val Ser Val Ile Ala Glu Arg Asn Lys Lys Lys Gln 
                645                 650                 655     


Leu Pro Tyr Tyr Tyr Leu Ser Pro Asp Arg Ile Pro Asn Ser Val Ala 
            660                 665                 670         


Ile 
    


<210>  2
<211>  691
<212>  PRT
<213>  Sol-5-LOX

<400>  2

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Pro Ser Tyr Thr Val Thr Val Ala Thr Gly Ser 
            20                  25                  30          


Gln Glu His Ala Gly Thr Asp Asp Tyr Ile Tyr Leu Ser Leu Val Gly 
        35                  40                  45              


Ser Ala Gly Cys Ser Glu Lys His Leu Leu Asp Lys Gly Ser Phe Glu 
    50                  55                  60                  


Arg Gly Ala Val Asp Ser Tyr Asp Val Thr Val Asp Glu Glu Leu Gly 
65                  70                  75                  80  


Glu Ile Gln Leu Val Arg Ile Glu Lys Arg Lys Tyr Gly Ser Asn Asp 
                85                  90                  95      


Asp Trp Tyr Leu Lys Tyr Ile Thr Leu Lys Thr Pro His Gly Asp Tyr 
            100                 105                 110         


Ile Glu Phe Pro Cys Tyr Arg Trp Ile Thr Gly Asp Val Glu Val Val 
        115                 120                 125             


Leu Arg Asp Gly Arg Ala Lys Leu Ala Arg Asp Asp Gln Ile His Ile 
    130                 135                 140                 


Leu Lys Gln His Arg Arg Lys Glu Leu Glu Thr Arg Gln Lys Gln Tyr 
145                 150                 155                 160 


Arg Trp Met Glu Trp Asn Pro Gly Phe Pro Leu Ser Ile Asp Ala Lys 
                165                 170                 175     


Cys His Lys Asp Leu Pro Arg Asp Ile Gln Phe Asp Ser Glu Lys Gly 
            180                 185                 190         


Val Asp Phe Val Leu Asn Tyr Ser Lys Ala Met Glu Asn Leu Phe Ile 
        195                 200                 205             


Asn Arg Phe Met His Met Phe Gln Ser Ser Trp Asn Asp Phe Ala Asp 
    210                 215                 220                 


Phe Glu Lys Ile Phe Val Lys Ile Ser Asn Thr Ile Ser Glu Arg Val 
225                 230                 235                 240 


Met Asn His Trp Gln Glu Asp Leu Met Phe Gly Tyr Gln Phe Leu Asn 
                245                 250                 255     


Gly Ala Asn Pro Val Leu Ile Arg Arg Cys Thr Glu Leu Pro Glu Lys 
            260                 265                 270         


Leu Pro Val Thr Thr Glu Met Val Glu Cys Ser Leu Glu Arg Gln Leu 
        275                 280                 285             


Ser Leu Glu Gln Glu Val Gln Gln Gly Asn Ile Phe Ile Val Asp Phe 
    290                 295                 300                 


Glu Leu Leu Asp Gly Ile Asp Ala Asn Lys Thr Asp Pro Cys Thr Leu 
305                 310                 315                 320 


Gln Phe Leu Ala Ala Pro Ile Cys Leu Leu Tyr Lys Asn Leu Ala Asn 
                325                 330                 335     


Lys Ile Val Pro Ile Ala Ile Gln Leu Asn Gln Ile Pro Gly Asp Glu 
            340                 345                 350         


Asn Pro Ile Phe Leu Pro Ser Asp Ala Lys Tyr Asp Trp Leu Leu Ala 
        355                 360                 365             


Lys Ile Trp Val Arg Ser Ser Asp Phe His Val His Gln Thr Ile Thr 
    370                 375                 380                 


His Leu Leu Arg Thr His Leu Val Ser Glu Val Phe Gly Ile Ala Met 
385                 390                 395                 400 


Tyr Arg Gln Leu Pro Ala Val His Pro Ile Phe Lys Leu Leu Val Ala 
                405                 410                 415     


His Val Arg Phe Thr Ile Ala Ile Asn Thr Lys Ala Arg Glu Gln Leu 
            420                 425                 430         


Ile Cys Glu Cys Gly Leu Phe Asp Lys Ala Asn Ala Thr Gly Gly Gly 
        435                 440                 445             


Gly His Val Gln Met Val Gln Arg Ala Met Lys Asp Leu Thr Tyr Ala 
    450                 455                 460                 


Ser Leu Cys Phe Pro Glu Ala Ile Lys Ala Arg Gly Met Glu Ser Lys 
465                 470                 475                 480 


Glu Asp Ile Pro Tyr Tyr Phe Tyr Arg Asp Asp Gly Leu Leu Val Trp 
                485                 490                 495     


Glu Ala Ile Arg Thr Phe Thr Ala Glu Val Val Asp Ile Tyr Tyr Glu 
            500                 505                 510         


Gly Asp Gln Val Val Glu Glu Asp Pro Glu Leu Gln Asp Phe Val Asn 
        515                 520                 525             


Asp Val Tyr Val Tyr Gly Met Arg Gly Arg Lys Ser Ser Gly Phe Pro 
    530                 535                 540                 


Lys Ser Val Lys Ser Arg Glu Gln Leu Ser Glu Tyr Leu Thr Val Val 
545                 550                 555                 560 


Ile Phe Thr Ala Ser Ala Gln His Ala Ala Val Asn Phe Gly Gln Tyr 
                565                 570                 575     


Asp Trp Ala Ser Trp Ile Pro Asn Ala Pro Pro Thr Met Arg Ala Pro 
            580                 585                 590         


Pro Pro Thr Ala Lys Gly Val Val Thr Ile Glu Gln Ile Val Asp Thr 
        595                 600                 605             


Leu Pro Asp Arg Gly Arg Ser Cys Trp His Leu Gly Ala Val Trp Ala 
    610                 615                 620                 


Leu Ser Gln Phe Gln Glu Asn Glu Leu Phe Leu Gly Met Tyr Pro Glu 
625                 630                 635                 640 


Glu His Phe Ile Glu Lys Pro Val Lys Glu Ala Met Ala Arg Phe Arg 
                645                 650                 655     


Lys Asn Leu Glu Ala Ile Val Ser Val Ile Ala Glu Arg Asn Lys Lys 
            660                 665                 670         


Lys Gln Leu Pro Tyr Tyr Tyr Leu Ser Pro Asp Arg Ile Pro Asn Ser 
        675                 680                 685             


Val Ala Ile 
    690     


<210>  3
<211>  691
<212>  PRT
<213>  Stable-5-LOX

<400>  3

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Pro Ser Tyr Thr Val Thr Val Ala Thr Gly Ser 
            20                  25                  30          


Gln Glu His Ala Gly Thr Asp Asp Tyr Ile Tyr Leu Ser Leu Val Gly 
        35                  40                  45              


Ser Ala Gly Cys Ser Glu Lys His Leu Leu Asp Lys Gly Ser Phe Glu 
    50                  55                  60                  


Arg Gly Ala Val Asp Ser Tyr Asp Val Thr Val Asp Glu Glu Leu Gly 
65                  70                  75                  80  


Glu Ile Gln Leu Val Arg Ile Glu Lys Arg Lys Tyr Gly Ser Asn Asp 
                85                  90                  95      


Asp Trp Tyr Leu Lys Tyr Ile Thr Leu Lys Thr Pro His Gly Asp Tyr 
            100                 105                 110         


Ile Glu Phe Pro Cys Tyr Arg Trp Ile Thr Gly Asp Val Glu Val Val 
        115                 120                 125             


Leu Arg Asp Gly Arg Ala Lys Leu Ala Arg Asp Asp Gln Ile His Ile 
    130                 135                 140                 


Leu Lys Gln His Arg Arg Lys Glu Leu Glu Thr Arg Gln Lys Gln Tyr 
145                 150                 155                 160 


Arg Trp Met Glu Trp Asn Pro Gly Phe Pro Leu Ser Ile Asp Ala Lys 
                165                 170                 175     


Cys His Lys Asp Leu Pro Arg Asp Ile Gln Phe Asp Ser Glu Lys Gly 
            180                 185                 190         


Val Asp Phe Val Leu Asn Tyr Ser Lys Ala Met Glu Asn Leu Phe Ile 
        195                 200                 205             


Asn Arg Phe Met His Met Phe Gln Ser Ser Trp Asn Asp Phe Ala Asp 
    210                 215                 220                 


Phe Glu Lys Ile Phe Val Lys Ile Ser Asn Thr Ile Ser Glu Arg Val 
225                 230                 235                 240 


Met Asn His Trp Gln Glu Asp Leu Met Phe Gly Tyr Gln Phe Leu Asn 
                245                 250                 255     


Gly Ala Asn Pro Val Leu Ile Arg Arg Cys Thr Glu Leu Pro Glu Lys 
            260                 265                 270         


Leu Pro Val Thr Thr Glu Met Val Glu Cys Ser Leu Glu Arg Gln Leu 
        275                 280                 285             


Ser Leu Glu Gln Glu Val Gln Gln Gly Asn Ile Phe Ile Val Asp Phe 
    290                 295                 300                 


Glu Leu Leu Asp Gly Ile Asp Ala Asn Lys Thr Asp Pro Cys Thr Leu 
305                 310                 315                 320 


Gln Phe Leu Ala Ala Pro Ile Cys Leu Leu Tyr Lys Asn Leu Ala Asn 
                325                 330                 335     


Lys Ile Val Pro Ile Ala Ile Gln Leu Asn Gln Ile Pro Gly Asp Glu 
            340                 345                 350         


Asn Pro Ile Phe Leu Pro Ser Asp Ala Lys Tyr Asp Trp Leu Leu Ala 
        355                 360                 365             


Lys Ile Trp Val Arg Ser Ser Asp Phe His Val His Gln Thr Ile Thr 
    370                 375                 380                 


His Leu Leu Arg Thr His Leu Val Ser Glu Val Phe Gly Ile Ala Met 
385                 390                 395                 400 


Tyr Arg Gln Leu Pro Ala Val His Pro Ile Phe Lys Leu Leu Val Ala 
                405                 410                 415     


His Val Arg Phe Thr Ile Ala Ile Asn Thr Lys Ala Arg Glu Gln Leu 
            420                 425                 430         


Ile Cys Glu Cys Gly Leu Phe Asp Lys Ala Asn Ala Thr Gly Gly Gly 
        435                 440                 445             


Gly His Val Gln Met Val Gln Arg Ala Met Lys Asp Leu Thr Tyr Ala 
    450                 455                 460                 


Ser Leu Cys Phe Pro Glu Ala Ile Lys Ala Arg Gly Met Glu Ser Lys 
465                 470                 475                 480 


Glu Asp Ile Pro Tyr Tyr Phe Tyr Arg Asp Asp Gly Leu Leu Val Trp 
                485                 490                 495     


Glu Ala Ile Arg Thr Phe Thr Ala Glu Val Val Asp Ile Tyr Tyr Glu 
            500                 505                 510         


Gly Asp Gln Val Val Glu Glu Asp Pro Glu Leu Gln Asp Phe Val Asn 
        515                 520                 525             


Asp Val Tyr Val Tyr Gly Met Arg Gly Arg Lys Ser Ser Gly Phe Pro 
    530                 535                 540                 


Lys Ser Val Lys Ser Arg Glu Gln Leu Ser Glu Tyr Leu Thr Val Val 
545                 550                 555                 560 


Ile Phe Thr Ala Ser Ala Gln His Ala Ala Val Asn Phe Gly Gln Tyr 
                565                 570                 575     


Asp Trp Ala Ser Trp Ile Pro Asn Ala Pro Pro Thr Met Arg Ala Pro 
            580                 585                 590         


Pro Pro Thr Ala Lys Gly Val Val Thr Ile Glu Gln Ile Val Asp Thr 
        595                 600                 605             


Leu Pro Asp Arg Gly Arg Ser Cys Trp His Leu Gly Ala Val Trp Ala 
    610                 615                 620                 


Leu Ser Gln Phe Gln Glu Asn Glu Leu Phe Leu Gly Met Tyr Pro Glu 
625                 630                 635                 640 


Glu His Phe Ile Glu Lys Pro Val Lys Glu Ala Met Ala Arg Phe Arg 
                645                 650                 655     


Lys Asn Leu Glu Ala Ile Val Ser Val Ile Ala Glu Arg Asn Glu Asn 
            660                 665                 670         


Leu Gln Leu Pro Tyr Tyr Tyr Leu Ser Pro Asp Arg Ile Pro Asn Ser 
        675                 680                 685             


Val Ala Ile 
    690     


<210>  4
<211>  691
<212>  PRT
<213>  S663D-Stable-5-LOX

<400>  4

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Pro Ser Tyr Thr Val Thr Val Ala Thr Gly Ser 
            20                  25                  30          


Gln Glu His Ala Gly Thr Asp Asp Tyr Ile Tyr Leu Ser Leu Val Gly 
        35                  40                  45              


Ser Ala Gly Cys Ser Glu Lys His Leu Leu Asp Lys Gly Ser Phe Glu 
    50                  55                  60                  


Arg Gly Ala Val Asp Ser Tyr Asp Val Thr Val Asp Glu Glu Leu Gly 
65                  70                  75                  80  


Glu Ile Gln Leu Val Arg Ile Glu Lys Arg Lys Tyr Gly Ser Asn Asp 
                85                  90                  95      


Asp Trp Tyr Leu Lys Tyr Ile Thr Leu Lys Thr Pro His Gly Asp Tyr 
            100                 105                 110         


Ile Glu Phe Pro Cys Tyr Arg Trp Ile Thr Gly Asp Val Glu Val Val 
        115                 120                 125             


Leu Arg Asp Gly Arg Ala Lys Leu Ala Arg Asp Asp Gln Ile His Ile 
    130                 135                 140                 


Leu Lys Gln His Arg Arg Lys Glu Leu Glu Thr Arg Gln Lys Gln Tyr 
145                 150                 155                 160 


Arg Trp Met Glu Trp Asn Pro Gly Phe Pro Leu Ser Ile Asp Ala Lys 
                165                 170                 175     


Cys His Lys Asp Leu Pro Arg Asp Ile Gln Phe Asp Ser Glu Lys Gly 
            180                 185                 190         


Val Asp Phe Val Leu Asn Tyr Ser Lys Ala Met Glu Asn Leu Phe Ile 
        195                 200                 205             


Asn Arg Phe Met His Met Phe Gln Ser Ser Trp Asn Asp Phe Ala Asp 
    210                 215                 220                 


Phe Glu Lys Ile Phe Val Lys Ile Ser Asn Thr Ile Ser Glu Arg Val 
225                 230                 235                 240 


Met Asn His Trp Gln Glu Asp Leu Met Phe Gly Tyr Gln Phe Leu Asn 
                245                 250                 255     


Gly Ala Asn Pro Val Leu Ile Arg Arg Cys Thr Glu Leu Pro Glu Lys 
            260                 265                 270         


Leu Pro Val Thr Thr Glu Met Val Glu Cys Ser Leu Glu Arg Gln Leu 
        275                 280                 285             


Ser Leu Glu Gln Glu Val Gln Gln Gly Asn Ile Phe Ile Val Asp Phe 
    290                 295                 300                 


Glu Leu Leu Asp Gly Ile Asp Ala Asn Lys Thr Asp Pro Cys Thr Leu 
305                 310                 315                 320 


Gln Phe Leu Ala Ala Pro Ile Cys Leu Leu Tyr Lys Asn Leu Ala Asn 
                325                 330                 335     


Lys Ile Val Pro Ile Ala Ile Gln Leu Asn Gln Ile Pro Gly Asp Glu 
            340                 345                 350         


Asn Pro Ile Phe Leu Pro Ser Asp Ala Lys Tyr Asp Trp Leu Leu Ala 
        355                 360                 365             


Lys Ile Trp Val Arg Ser Ser Asp Phe His Val His Gln Thr Ile Thr 
    370                 375                 380                 


His Leu Leu Arg Thr His Leu Val Ser Glu Val Phe Gly Ile Ala Met 
385                 390                 395                 400 


Tyr Arg Gln Leu Pro Ala Val His Pro Ile Phe Lys Leu Leu Val Ala 
                405                 410                 415     


His Val Arg Phe Thr Ile Ala Ile Asn Thr Lys Ala Arg Glu Gln Leu 
            420                 425                 430         


Ile Cys Glu Cys Gly Leu Phe Asp Lys Ala Asn Ala Thr Gly Gly Gly 
        435                 440                 445             


Gly His Val Gln Met Val Gln Arg Ala Met Lys Asp Leu Thr Tyr Ala 
    450                 455                 460                 


Ser Leu Cys Phe Pro Glu Ala Ile Lys Ala Arg Gly Met Glu Ser Lys 
465                 470                 475                 480 


Glu Asp Ile Pro Tyr Tyr Phe Tyr Arg Asp Asp Gly Leu Leu Val Trp 
                485                 490                 495     


Glu Ala Ile Arg Thr Phe Thr Ala Glu Val Val Asp Ile Tyr Tyr Glu 
            500                 505                 510         


Gly Asp Gln Val Val Glu Glu Asp Pro Glu Leu Gln Asp Phe Val Asn 
        515                 520                 525             


Asp Val Tyr Val Tyr Gly Met Arg Gly Arg Lys Ser Ser Gly Phe Pro 
    530                 535                 540                 


Lys Ser Val Lys Ser Arg Glu Gln Leu Ser Glu Tyr Leu Thr Val Val 
545                 550                 555                 560 


Ile Phe Thr Ala Ser Ala Gln His Ala Ala Val Asn Phe Gly Gln Tyr 
                565                 570                 575     


Asp Trp Ala Ser Trp Ile Pro Asn Ala Pro Pro Thr Met Arg Ala Pro 
            580                 585                 590         


Pro Pro Thr Ala Lys Gly Val Val Thr Ile Glu Gln Ile Val Asp Thr 
        595                 600                 605             


Leu Pro Asp Arg Gly Arg Ser Cys Trp His Leu Gly Ala Val Trp Ala 
    610                 615                 620                 


Leu Ser Gln Phe Gln Glu Asn Glu Leu Phe Leu Gly Met Tyr Pro Glu 
625                 630                 635                 640 


Glu His Phe Ile Glu Lys Pro Val Lys Glu Ala Met Ala Arg Phe Arg 
                645                 650                 655     


Lys Asn Leu Glu Ala Ile Val Ser Val Ile Ala Glu Arg Asn Glu Asn 
            660                 665                 670         


Leu Gln Leu Pro Tyr Tyr Tyr Leu Asp Pro Asp Arg Ile Pro Asn Ser 
        675                 680                 685             


Val Ala Ile 
    690     


<210>  5
<211>  20
<212>  PRT
<213>  Histidene tab/linker

<400>  5

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His 
            20  


<210>  6
<211>  29
<212>  PRT
<213>  B. taurus - 5-LOX - C-terminus

<400>  6

Val Ser Val Ile Ala Glu Arg Asn Lys Asn Lys Lys Leu Pro Tyr Tyr 
1               5                   10                  15      


Tyr Leu Ser Pro Asp Arg Ile Pro Asn Ser Val Ala Ile 
            20                  25                  


<210>  7
<211>  29
<212>  PRT
<213>  S. scrofa - 5-LOX - C-terminus

<400>  7

Val Ser Val Ile Ala Glu Arg Asn Lys Asp Lys Lys Leu Pro Tyr Tyr 
1               5                   10                  15      


Tyr Leu Ser Pro Asp Arg Ile Pro Asn Ser Val Ala Ile 
            20                  25                  


<210>  8
<211>  29
<212>  PRT
<213>  M. mulata - 5-LOX - C-terminus

<400>  8

Val Ser Val Ile Ala Glu Arg Asn Lys Lys Lys Gln Leu Pro Tyr Tyr 
1               5                   10                  15      


Tyr Leu Ser Pro Asp Arg Ile Pro Asn Ser Val Ala Ile 
            20                  25                  


<210>  9
<211>  29
<212>  PRT
<213>  M. musculus - 5-LOX - C-terminus

<400>  9

Val Ser Val Ile Ala Glu Arg Asn Lys Asn Lys Lys Leu Pro Tyr Tyr 
1               5                   10                  15      


Tyr Leu Ser Pro Asp Arg Ile Pro Asn Ser Val Ala Ile 
            20                  25                  


<210>  10
<211>  29
<212>  PRT
<213>  M. Auratus - 5-LOX - C-terminus

<400>  10

Val Asn Val Ile Ala Glu Arg Asn Lys Asn Lys Lys Leu Pro Tyr Tyr 
1               5                   10                  15      


Tyr Leu Ser Pro Asp Arg Ile Pro Asn Ser Val Ala Ile 
            20                  25                  


<210>  11
<211>  29
<212>  PRT
<213>  O. cuniculus - 5-LOX - C-terminus

<400>  11

Val Ser Val Ile Ala Glu Arg Asn Lys His Lys Lys Leu Pro Tyr Tyr 
1               5                   10                  15      


Tyr Leu Ser Pro Asp Arg Ile Pro Asn Ser Val Ala Ile 
            20                  25                  


<210>  12
<211>  29
<212>  PRT
<213>  M. domestica - 5-LOX - C-terminus

<400>  12

Val Ser Gly Ile Thr Glu Arg Asn Lys Asn Lys Lys Leu Pro Tyr Tyr 
1               5                   10                  15      


Tyr Leu Ser Pro Asp Arg Ile Pro Asn Ser Val Ala Ile 
            20                  25                  


<210>  13
<211>  29
<212>  PRT
<213>  D. rerio - 5-LOX - C-terminus

<400>  13

Ser Lys Thr Ile Lys Asn Arg Asn Glu Gly Lys Lys Leu Pro Tyr Tyr 
1               5                   10                  15      


Tyr Leu Ser Pro Asp Arg Ile Pro Asn Ser Val Ala Val 
            20                  25                  


<210>  14
<211>  29
<212>  PRT
<213>  S. salar - 5-LOX - C-terminus

<400>  14

Ser Ser Ala Ile Lys Ile Arg Asn Glu Gly Lys Lys Leu Pro Tyr Tyr 
1               5                   10                  15      


Tyr Phe Ser Pro Asp Arg Ile Pro Asn Ser Val Ala Val 
            20                  25                  


<210>  15
<211>  29
<212>  PRT
<213>  H. sapiens - 12R-LOX - C-terminus

<400>  15

Ser His Asp Ile Arg Gln Arg Asn Lys Cys Leu Pro Ile Pro Tyr Tyr 
1               5                   10                  15      


Tyr Leu Asp Pro Val Leu Ile Glu Asn Ser Ile Ser Ile 
            20                  25                  


<210>  16
<211>  29
<212>  PRT
<213>  H. sapiens - E3-LOX - C-terminus

<400>  16

Ser Arg Asp Ile Gln Glu Arg Asn Gln Gly Leu Ala Leu Pro Tyr Thr 
1               5                   10                  15      


Tyr Leu Asp Pro Pro Leu Ile Glu Asn Ser Val Ser Ile 
            20                  25                  


<210>  17
<211>  29
<212>  PRT
<213>  H. sapiens - 15B-LOX - C-terminus

<400>  17

Ser Arg Gly Ile Gln Glu Arg Asn Gln Gly Leu Val Leu Pro Tyr Thr 
1               5                   10                  15      


Tyr Leu Asp Pro Pro Leu Ile Glu Asn Ser Val Ser Ile 
            20                  25                  


<210>  18
<211>  29
<212>  PRT
<213>  H. sapiens - 15A-LOX - C-terminus

<400>  18

Asp Lys Glu Ile Glu Ile Arg Asn Ala Lys Leu Asp Met Pro Tyr Glu 
1               5                   10                  15      


Tyr Leu Arg Pro Ser Val Val Glu Asn Ser Val Ala Ile 
            20                  25                  


<210>  19
<211>  29
<212>  PRT
<213>  O. cuniculus - 15-LOX - C-terminus

<400>  19

Asp Lys Glu Ile Glu Val Arg Asn Glu Lys Leu Asp Ile Pro Tyr Glu 
1               5                   10                  15      


Tyr Leu Arg Pro Ser Ile Val Glu Asn Ser Val Ala Ile 
            20                  25                  


<210>  20
<211>  29
<212>  PRT
<213>  H. sapiens - 12S-LOX - C-terminus

<400>  20

Glu Lys Glu Ile Thr Ala Arg Asn Glu Gln Leu Asp Trp Pro Tyr Glu 
1               5                   10                  15      


Tyr Leu Lys Pro Ser Cys Ile Glu Asn Ser Val Thr Ile 
            20                  25                  


<210>  21
<211>  29
<212>  PRT
<213>  homomalla - 8R-LOX - C-terminus

<400>  21

Ser Lys Lys Ile Lys Gln Arg Asn Glu Asn Leu Glu Val Pro Tyr Ile 
1               5                   10                  15      


Tyr Leu Leu Pro Glu Arg Ile Pro Asn Gly Thr Ala Ile 
            20                  25                  


