                         SEQUENCE LISTING

<110>  University of Chicago

       Salgia, Ravi
       Krishneswamy, Sounarajan
       Tan, Yi-Hung Carol
       Nandi, Suvobroto
 
<120>  c-CBL MUTATIONS AND USES THEREOF

<130>  21117.0019P1

<150>  61/351,501
<151>  2010-06-04

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  2720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  1
atggccggca acgtgaagaa gagctctggg gccgggggcg gcagcggctc cgggggctcg       60

ggttcgggtg gcctgattgg gctcatgaag gacgccttcc agccgcacca ccaccaccac      120

caccacctca gcccccaccc gccggggacg gtggacaaga agatggtgga gaagtgctgg      180

aagctcatgg acaaggtggt gcggttgtgt cagaacccaa agctggcgct aaagaatagc      240

ccaccttata tcttagacct gctaccagat acctaccagc atctccgtac tatcttgtca      300

agatatgagg ggaagatgga gacacttgga gaaaatgagt attttagggt gtttatggag      360

aatttgatga agaaaactaa gcaaaccata agcctcttca aggagggaaa agaaagaatg      420

tatgaggaga attctcagcc taggcgaaac ctaaccaaac tgtccctcat cttcagccac      480

atgctggcag aactaaaagg aatctttcca agtggactct ttcagggaga cacatttcgg      540

attactaaag cagatgctgc ggaattttgg agaaaagctt ttggggaaaa gacaatagtc      600

ccttggaaga gctttcgaca ggctctacat gaagtgcatc ccatcagttc tgggctggag      660

gccatggctc tgaaatccac tattgatctg acctgcaatg attatatttc ggtttttgaa      720

tttgacatct ttacccgact ctttcagccc tggtcctctt tgctcaggaa ttggaacagc      780

cttgctgtaa ctcatcctgg ctacatggct tttttgacgt atgacgaagt gaaagctcgg      840

ctccagaaat tcattcacaa acctggcagt tatatcttcc ggctgagctg tactcgtctg      900

ggtcagtggg ctattgggta tgttactgct gatgggaaca ttctccagac aatccctcac      960

aataaacctc tcttccaagc actgattgat ggcttcaggg aaggcttcta tttgtttcct     1020

gatggacgaa atcagaatcc tgatctgact ggcttatgtg aaccaactcc ccaagaccat     1080

atcaaagtga cccaggaaca atatgaatta tactgtgaga tgggctccac attccaacta     1140

tgtaaaatat gtgctgaaaa tgataaggat gtaaagattg agccctgtgg acacctcatg     1200

tgcacatcct gtcttacatc ctggcaggaa tcagaaggtc agggctgtcc tttctgccga     1260

tgtgaaatta aaggtactga acccatcgtg gtagatccgt ttgatcctag agggagtggc     1320

agcctgttga ggcaaggagc agagggagct ccctccccaa attatgatga tgatgatgat     1380

gaacgagctg atgatactct cttcatgatg aaggaattgg ctggtgccaa ggtggaacgg     1440

ccgccttctc cattctccat ggccccacaa gcttcccttc ccccggtgcc accacgactt     1500

gaccttctgc cgcagcgagt atgtgttccc tcaagtgctt ctgctcttgg aactgcttct     1560

aaggctgctt ctggctccct tcataaagac aaaccattgc cagtacctcc cacacttcga     1620

gatcttccac caccaccgcc tccagaccgg ccatattctg ttggagcaga atcccgacct     1680

caaagacgcc ccttgccttg tacaccaggc gactgtccct ccagagacaa actgccccct     1740

gtcccctcta gccgccttgg agactcatgg ctgccccggc caatccccaa agtaccagta     1800

tctgccccaa gttccagtga tccctggaca ggaagagaat taaccaaccg gcactcactt     1860

ccattttcat tgccctcaca aatggagccc agaccagatg tgcctaggct cggaagcacg     1920

ttcagtctgg atacctccat gagtatgaat agcagcccat tagtaggtcc agagtgtgac     1980

caccccaaaa tcaaaccttc ctcatctgcc aatgccattt attctctggc tgccagacct     2040

cttcctgtgc caaaactgcc acctggggag caatgtgagg gtgaagagga cacaagtaca     2100

tgactccctc ttccaggcct ctacggcctt tggatacatc ccagagttca cgagcatgtg     2160

attgcgacca gcagattgat agctgtacgt atgaagcaat gtataatatt cagtcccagg     2220

cgccatctat caccgagagc agcacctttg gtgaagggaa tttggccgca gcccatgcca     2280

acactggtcc cgaggagtca gaaaatgagg atgatgggta tgatgtccca aagccacctg     2340

tgccggccgt gctggcccgc cgaactctct cagatatctc taatgccagc tcctcctttg     2400

gctggttgtc tctggatggt gatcctacaa caaatgtcac tgaaggttcc caagttcccg     2460

agaggcctcc aaaaccattc ccgcggagaa tcaactctga acggaaagct ggcagctgtc     2520

agcaaggtag tggtcctgcc gcctctgctg ccaccgcctc acctcagctc tccagtgaga     2580

tcgagaacct catgagtcag gggtactcct accaggacat ccagaaagct ttggtcattg     2640

cccagaacaa catcgagatg gccaaaaaca tcctccggga atttgtttcc atttcttctc     2700

ctgcccatgt agctacctag                                                 2720


<210>  2
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  2

Met Ala Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Ser Gly 
1               5                   10                  15      


Ser Gly Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala 
            20                  25                  30          


Phe Gln Pro His His His His His His His Leu Ser Pro His Pro Pro 
        35                  40                  45              


Gly Thr Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp 
    50                  55                  60                  


Lys Val Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser 
65                  70                  75                  80  


Pro Pro Tyr Ile Leu Asp Leu Leu Pro Asp Thr Tyr Gln His Leu Arg 
                85                  90                  95      


Thr Ile Leu Ser Arg Tyr Glu Gly Lys Met Glu Thr Leu Gly Glu Asn 
            100                 105                 110         


Glu Tyr Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Thr Lys Gln 
        115                 120                 125             


Thr Ile Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn 
    130                 135                 140                 


Ser Gln Pro Arg Arg Asn Leu Thr Lys Leu Ser Leu Ile Phe Ser His 
145                 150                 155                 160 


Met Leu Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly 
                165                 170                 175     


Asp Thr Phe Arg Ile Thr Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys 
            180                 185                 190         


Ala Phe Gly Glu Lys Thr Ile Val Pro Trp Lys Ser Phe Arg Gln Ala 
        195                 200                 205             


Leu His Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu 
    210                 215                 220                 


Lys Ser Thr Ile Asp Leu Thr Cys Asn Asp Tyr Ile Ser Val Phe Glu 
225                 230                 235                 240 


Phe Asp Ile Phe Thr Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg 
                245                 250                 255     


Asn Trp Asn Ser Leu Ala Val Thr His Pro Gly Tyr Met Ala Phe Leu 
            260                 265                 270         


Thr Tyr Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro 
        275                 280                 285             


Gly Ser Tyr Ile Phe Arg Leu Ser Cys Thr Arg Leu Gly Gln Trp Ala 
    290                 295                 300                 


Ile Gly Tyr Val Thr Ala Asp Gly Asn Ile Leu Gln Thr Ile Pro His 
305                 310                 315                 320 


Asn Lys Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe 
                325                 330                 335     


Tyr Leu Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Thr Gly Leu 
            340                 345                 350         


Cys Glu Pro Thr Pro Gln Asp His Ile Lys Val Thr Gln Glu Gln Tyr 
        355                 360                 365             


Glu Leu Tyr Cys Glu Met Gly Ser Thr Phe Gln Leu Cys Lys Ile Cys 
    370                 375                 380                 


Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met 
385                 390                 395                 400 


Cys Thr Ser Cys Leu Thr Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys 
                405                 410                 415     


Pro Phe Cys Arg Cys Glu Ile Lys Gly Thr Glu Pro Ile Val Val Asp 
            420                 425                 430         


Pro Phe Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu 
        435                 440                 445             


Gly Ala Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp 
    450                 455                 460                 


Asp Thr Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Val Glu Arg 
465                 470                 475                 480 


Pro Pro Ser Pro Phe Ser Met Ala Pro Gln Ala Ser Leu Pro Pro Val 
                485                 490                 495     


Pro Pro Arg Leu Asp Leu Leu Pro Gln Arg Val Cys Val Pro Ser Ser 
            500                 505                 510         


Ala Ser Ala Leu Gly Thr Ala Ser Lys Ala Ala Ser Gly Ser Leu His 
        515                 520                 525             


Lys Asp Lys Pro Leu Pro Val Pro Pro Thr Leu Arg Asp Leu Pro Pro 
    530                 535                 540                 


Pro Pro Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala Glu Ser Arg Pro 
545                 550                 555                 560 


Gln Arg Arg Pro Leu Pro Cys Thr Pro Gly Asp Cys Pro Ser Arg Asp 
                565                 570                 575     


Lys Leu Pro Pro Val Pro Ser Ser Arg Leu Gly Asp Ser Trp Leu Pro 
            580                 585                 590         


Arg Pro Ile Pro Lys Val Pro Val Ser Ala Pro Ser Ser Ser Asp Pro 
        595                 600                 605             


Trp Thr Gly Arg Glu Leu Thr Asn Arg His Ser Leu Pro Phe Ser Leu 
    610                 615                 620                 


Pro Ser Gln Met Glu Pro Arg Pro Asp Val Pro Arg Leu Gly Ser Thr 
625                 630                 635                 640 


Phe Ser Leu Asp Thr Ser Met Ser Met Asn Ser Ser Pro Leu Val Gly 
                645                 650                 655     


Pro Glu Cys Asp His Pro Lys Ile Lys Pro Ser Ser Ser Ala Asn Ala 
            660                 665                 670         


Ile Tyr Ser Leu Ala Ala Arg Pro Leu Pro Val Pro Lys Leu Pro Pro 
        675                 680                 685             


Gly Glu Gln Cys Glu Gly Glu Glu Asp Thr Glu Tyr Met Thr Pro Ser 
    690                 695                 700                 


Ser Arg Pro Leu Arg Pro Leu Asp Thr Ser Gln Ser Ser Arg Ala Cys 
705                 710                 715                 720 


Asp Cys Asp Gln Gln Ile Asp Ser Cys Thr Tyr Glu Ala Met Tyr Asn 
                725                 730                 735     


Ile Gln Ser Gln Ala Pro Ser Ile Thr Glu Ser Ser Thr Phe Gly Glu 
            740                 745                 750         


Gly Asn Leu Ala Ala Ala His Ala Asn Thr Gly Pro Glu Glu Ser Glu 
        755                 760                 765             


Asn Glu Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val 
    770                 775                 780                 


Leu Ala Arg Arg Thr Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe 
785                 790                 795                 800 


Gly Trp Leu Ser Leu Asp Gly Asp Pro Thr Thr Asn Val Thr Glu Gly 
                805                 810                 815     


Ser Gln Val Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn 
            820                 825                 830         


Ser Glu Arg Lys Ala Gly Ser Cys Gln Gln Gly Ser Gly Pro Ala Ala 
        835                 840                 845             


Ser Ala Ala Thr Ala Ser Pro Gln Leu Ser Ser Glu Ile Glu Asn Leu 
    850                 855                 860                 


Met Ser Gln Gly Tyr Ser Tyr Gln Asp Ile Gln Lys Ala Leu Val Ile 
865                 870                 875                 880 


Ala Gln Asn Asn Ile Glu Met Ala Lys Asn Ile Leu Arg Glu Phe Val 
                885                 890                 895     


Ser Ile Ser Ser Pro Ala His Val Ala Thr 
            900                 905     


<210>  3
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  3
taaaatggtt gcctgtgggc aatg                                              24


<210>  4
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  4
catcttgtat ggtgaatttg gtgc                                              24


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  5
gcttaatgtg gctctccttc c                                                 21


<210>  6
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  6
ctctgagttg gttgtacatc tgac                                              24


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  7
gtctgtatct tgccttgcct tc                                                22


<210>  8
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  8
ggacccagac tagatgcttt ctg                                               23


<210>  9
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  9
cggtattata tagcctttac tgatacaagg                                        30


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  10
cctaggtctg gcccatttgt ag                                                22


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  11
cagaggctca gctgtggtaa g                                                 21


<210>  12
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  12
gctctgttca atttgagtta tgtctg                                            26


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  13
gttggcccac agtagacaat c                                                 21


<210>  14
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  14
cttgtgactg aagagcacat gtac                                              24


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  15
tgtgttaccc attcaggcac tc                                                22


<210>  16
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  16
gactccgtct caaaaagaaa ccac                                              24


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  17
gtgaggagaa gaaagcagtt gg                                                22


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  18
cagaaccttg gctattgcga aac                                               23


<210>  19
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  19
cctaagttcc cagactctaa cagatg                                            26


<210>  20
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  20
ccttgtatca gtaaaggcta tataatacc                                         29


<210>  21
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  21
ccagtctcct aaactgccat cttac                                             25


<210>  22
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  22
ctggcccaca catatttctt aacag                                             25


<210>  23
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  23
cagagcaatg aaacagatgg cag                                               23


<210>  24
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  24
gcttagatca agctatctca attgcc                                            26


<210>  25
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  25
cttgggactt tcctcccatt tagac                                             25


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  26
ctaggtgcca cttgagtaat aactc                                             25


<210>  27
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  27
gctggcgcta aagaataacc caccttatat cttagac                                37


<210>  28
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  28
ctaccagata cctaccagta tctccgtact atcttgtc                               38


<210>  29
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  29
ctttacccga ctctttgagc cctggtcctc tttgc                                  35


<210>  30
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  30
agctcctcct ttggctgatt gtctctggat ggtgatc                                37


<210>  31
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: note = synthetic construct

<400>  31
ctttacccga ctctttgagc cctggtcctc tttgc                                  35


