                         SEQUENCE LISTING

<110>  Rui, et al.
 
<120>  METHODS OF TREATING METABOLIC DISORDERS AND CARDIOVASCULAR 
       DISEASES

<130>  30275/45409A

<150>  US-61/353,550
<151>  2010-06-10

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  176
<212>  PRT
<213>  Mus musculus

<400>  1

Met Lys Ser Leu Leu Leu Thr Ile Leu Leu Leu Gly Leu Val Ala Val 
1               5                   10                  15      


Leu Lys Ala Gln Glu Ala Pro Pro Asp Asp Leu Val Asp Tyr Ser Gly 
            20                  25                  30          


Ile Trp Tyr Ala Lys Ala Met Val His Asn Gly Thr Leu Pro Ser His 
        35                  40                  45              


Lys Ile Pro Ser Ile Val Phe Pro Val Arg Ile Ile Ala Leu Glu Glu 
    50                  55                  60                  


Gly Asp Leu Glu Thr Thr Val Val Phe Trp Asn Asn Gly His Cys Arg 
65                  70                  75                  80  


Glu Phe Lys Phe Val Met Lys Lys Thr Glu Glu Pro Gly Lys Tyr Thr 
                85                  90                  95      


Ala Phe His Asn Thr Lys Val Ile His Val Glu Lys Thr Ser Val Asn 
            100                 105                 110         


Glu His Tyr Ile Phe Tyr Cys Glu Gly Arg His Asn Gly Thr Ser Ser 
        115                 120                 125             


Phe Gly Met Gly Lys Leu Met Gly Arg Asp Ser Gly Glu Asn Pro Glu 
    130                 135                 140                 


Ala Met Glu Glu Phe Lys Asn Phe Ile Lys Arg Met Asn Leu Arg Leu 
145                 150                 155                 160 


Glu Asn Met Phe Val Pro Glu Ile Gly Asp Lys Cys Val Glu Ser Asp 
                165                 170                 175     


<210>  2
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  2
gtcattcggg atgggaaag                                                    19


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  3
gctgttgcag acctgggta                                                    19


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  4
aaatcgtgcg tgacatcaaa                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  5
aaggaaggct ggaaaagagc                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  6
atcatctttg gtggccgtag                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  7
atcttgccct tgtgttctgc                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  8
ccggtgtttg aacgtcatct                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  9
caatgcctga caagactcca                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  10
tggacggaag caatttttca                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  11
ttacctgcgc aagcttctct                                                   20


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  12
aagcgcgtcc tggcattgtc t                                                 21


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  13
ccgcaggggc agcagtggt                                                    19


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  14
ctggggacct aaacaggagc                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  15
gaagccaccc tatagctccc                                                   20


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  16
ctgatgacgg ctatggtgtt t                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  17
gtgaggccaa acaaggtgat a                                                 21


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  18
ttgacggctc acacacctac                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  19
cgatcttcca ggctcttcag                                                   20


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  20
cactcagata ttgtcatgcc ct                                                22


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  21
tccattgaga atccaatcac tc                                                22


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  22
accctgtgga gaagctgatg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  23
agcaacagtg cttggagctt                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  24
ccagagtctg ctgatctgcg                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  25
gccacctctt tgctctgatc                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  26
aggtgcctct tagccactga                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  27
ccaggagttt cttgggttga                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  28
aacgtcactt ccagctagac                                                   20


<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  29
ccactaaggt gcctacagag c                                                 21


<210>  30
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Lys Pro Leu Leu Leu Ala Val Ser Leu Gly Leu Ile Ala Ala Leu 
1               5                   10                  15      


Gln Ala His His Leu Leu Ala Ser Asp Glu Glu Ile Gln Asp Val Ser 
            20                  25                  30          


Gly Thr Trp Tyr Leu Lys Ala Met Thr Val Asp Arg Glu Phe Pro Glu 
        35                  40                  45              


Met Asn Leu Glu Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly 
    50                  55                  60                  


Gly Asn Leu Glu Ala Lys Val Thr Met Leu Ile Ser Gly Arg Cys Gln 
65                  70                  75                  80  


Glu Val Lys Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr 
                85                  90                  95      


Ala Asp Gly Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys 
            100                 105                 110         


Asp His Tyr Ile Phe Tyr Cys Glu Gly Glu Leu His Gly Lys Pro Val 
        115                 120                 125             


Arg Gly Val Lys Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala 
    130                 135                 140                 


Leu Glu Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu 
145                 150                 155                 160 


Ser Ile Leu Ile Pro Arg Gln Ser Glu Thr Cys Ser Pro Gly Ser Asp 
                165                 170                 175     


<210>  31
<211>  187
<212>  PRT
<213>  Mus musculus

<400>  31

Met Gln Thr Leu Glu Met Arg Ala Leu Leu Leu Ile Ile Ser Phe Cys 
1               5                   10                  15      


Leu Val Ala Val Leu Gln Ala Gln Asp Ser Ser Phe Leu Ala Phe Asn 
            20                  25                  30          


Asn Gly Asn Phe Ser Gly Lys Trp Phe Leu Lys Ala Leu Val Ser Glu 
        35                  40                  45              


Asp Asp Ile Pro Ile Asn Lys Val Ser Pro Met Leu Ile Leu Val Leu 
    50                  55                  60                  


Asn Asn Gly Asp Ile Glu Leu Ser Ile Thr His Met Ile Tyr Asp Gln 
65                  70                  75                  80  


Cys Leu Glu Val Thr Thr Ile Leu Glu Lys Thr Asp Val Pro Gly Gln 
                85                  90                  95      


Tyr Leu Ala Phe Glu Gly Lys Thr His Leu Gln Val Gln Leu Ser Ser 
            100                 105                 110         


Val Lys Gly His Tyr Met Leu Tyr Cys Asp Gly Glu Ile Glu Gly Met 
        115                 120                 125             


Arg Phe Leu Met Thr Gln Leu Ile Gly Arg Asp Pro Gln Glu Asn Leu 
    130                 135                 140                 


Glu Ala Leu Glu Glu Phe Lys Val Phe Thr Gln Ile Lys Gly Leu Val 
145                 150                 155                 160 


Ala Glu Asn Leu Val Ile Leu Glu Gln Met Glu Lys Cys Glu Pro Glu 
                165                 170                 175     


Ser Phe Tyr Glu Leu Pro Ser Arg Pro Ser Glu 
            180                 185         


<210>  32
<211>  185
<212>  PRT
<213>  Mus musculus

<400>  32

Met Lys Ser Leu Leu Leu Thr Val Thr Leu Ser Ser Leu Val Ala Thr 
1               5                   10                  15      


Leu Gln Thr Tyr Asp Asp Leu Pro Phe Ile Ser Glu Glu Asp Lys Leu 
            20                  25                  30          


Ser Gly Val Trp Phe Ile Lys Ala Thr Val Ser Gln Arg Arg Glu Val 
        35                  40                  45              


Glu Gly Glu Thr Leu Val Ala Phe Pro Ile Lys Phe Thr Cys Pro Glu 
    50                  55                  60                  


Glu Gly Thr Leu Glu Leu Arg His Thr Leu Ala Ser Lys Gly Glu Cys 
65                  70                  75                  80  


Ile Asn Val Gly Ile Arg Leu Gln Arg Thr Glu Glu Pro Gly Gln Tyr 
                85                  90                  95      


Ser Ala Phe Trp Gly His Thr Leu Phe Tyr Ile Tyr Asp Leu Pro Val 
            100                 105                 110         


Lys Asp His Tyr Ile Ile Tyr Cys Glu Ser His Pro Phe Gln Lys Ile 
        115                 120                 125             


Ser Gln Phe Gly Tyr Leu Ile Gly Lys Tyr Pro Glu Glu Asn Gln Asp 
    130                 135                 140                 


Thr Leu Glu Val Phe Lys Glu Phe Ile Gln His Lys Gly Phe Leu Gln 
145                 150                 155                 160 


Glu Lys Ile Gly Val Pro Glu Gln Arg Asp Arg Cys Ile Pro Ile His 
                165                 170                 175     


Asp Ser Ala His Gln Asp His Lys Cys 
            180                 185 


<210>  33
<211>  176
<212>  PRT
<213>  Mus musculus

<400>  33

Met Lys Ser Leu Leu Leu Thr Ile Leu Leu Leu Gly Leu Val Ala Val 
1               5                   10                  15      


Leu Lys Ala Gln Glu Ala Pro Pro Asp Asp Leu Glu Asp Phe Ser Gly 
            20                  25                  30          


Ile Trp Tyr Thr Gln Ala Met Val Ser Asp Arg Asn His Thr Asp Gly 
        35                  40                  45              


Lys Arg Pro Met Lys Val Phe Pro Met Thr Val Ile Ala Leu Glu Gly 
    50                  55                  60                  


Gly Ser Leu Glu Ala Gln Leu Thr Phe Trp Asp Asn Gly His Cys His 
65                  70                  75                  80  


Met Lys Lys Ile Leu Met His Lys Thr Asp Glu Pro His Lys Tyr Thr 
                85                  90                  95      


Ala Phe Lys Gly Lys Lys Thr Ile Tyr Ile Gln Glu Thr Ser Val Lys 
            100                 105                 110         


Gly Tyr Tyr Ile Leu Tyr Cys Glu Gly Gln Arg His Gly Arg Ser His 
        115                 120                 125             


Arg Lys Gly Lys Leu Ile Gly Thr Asn Ser Glu Lys Asn Pro Glu Ala 
    130                 135                 140                 


Met Glu Glu Phe Lys Lys Phe Ala Met Ser Lys Gly Phe Arg Glu Glu 
145                 150                 155                 160 


Asn Ile Ile Val Pro Glu Gln Leu Asp Gln Cys Val Ser Gly Ser Asn 
                165                 170                 175     


<210>  34
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Lys Thr Leu Phe Leu Gly Val Thr Leu Gly Leu Ala Ala Ala Leu 
1               5                   10                  15      


Ser Phe Thr Leu Glu Glu Glu Asp Ile Thr Gly Thr Trp Tyr Val Lys 
            20                  25                  30          


Ala Met Val Val Asp Lys Asp Phe Pro Glu Asp Arg Arg Pro Arg Lys 
        35                  40                  45              


Val Ser Pro Val Lys Val Thr Ala Leu Gly Gly Gly Lys Leu Glu Ala 
    50                  55                  60                  


Thr Phe Thr Phe Met Arg Glu Asp Arg Cys Ile Gln Lys Lys Ile Leu 
65                  70                  75                  80  


Met Arg Lys Thr Glu Glu Pro Gly Lys Tyr Ser Ala Tyr Gly Gly Arg 
                85                  90                  95      


Lys Leu Met Tyr Leu Gln Glu Leu Pro Arg Arg Asp His Tyr Ile Phe 
            100                 105                 110         


Tyr Cys Lys Asp Gln His His Gly Gly Leu Leu His Met Gly Lys Leu 
        115                 120                 125             


Val Gly Arg Asn Ser Asp Thr Asn Arg Glu Ala Leu Glu Glu Phe Lys 
    130                 135                 140                 


Lys Leu Val Gln Arg Lys Gly Leu Ser Glu Glu Asp Ile Phe Thr Pro 
145                 150                 155                 160 


Leu Gln Thr Gly Ser Cys Val Pro Glu His 
                165                 170 


<210>  35
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Lys Thr Leu Phe Leu Gly Val Thr Leu Gly Leu Ala Ala Ala Leu 
1               5                   10                  15      


Ser Phe Thr Leu Glu Glu Glu Asp Ile Thr Gly Thr Trp Tyr Val Lys 
            20                  25                  30          


Ala Met Val Val Asp Lys Asp Phe Pro Glu Asp Arg Arg Pro Arg Lys 
        35                  40                  45              


Val Ser Pro Val Lys Val Thr Ala Leu Gly Gly Gly Asn Leu Glu Ala 
    50                  55                  60                  


Thr Phe Thr Phe Met Arg Glu Asp Arg Cys Ile Gln Lys Lys Ile Leu 
65                  70                  75                  80  


Met Arg Lys Thr Glu Glu Pro Gly Lys Phe Ser Ala Tyr Gly Gly Arg 
                85                  90                  95      


Lys Leu Ile Tyr Leu Gln Glu Leu Pro Gly Thr Asp Asp Tyr Val Phe 
            100                 105                 110         


Tyr Cys Lys Asp Gln Arg Arg Gly Gly Leu Arg Tyr Met Gly Lys Leu 
        115                 120                 125             


Val Gly Arg Asn Pro Asn Thr Asn Leu Glu Ala Leu Glu Glu Phe Lys 
    130                 135                 140                 


Lys Leu Val Gln His Lys Gly Leu Ser Glu Glu Asp Ile Phe Met Pro 
145                 150                 155                 160 


Leu Gln Thr Gly Ser Cys Val Leu Glu His 
                165                 170 


