                         SEQUENCE LISTING

<110>  UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF 
       HIGHER EDUCATION
       Ferrone, Soldano
       Wang, Xinhui
       Conrads, Thomas P.
       Favoino,  Elvira
       Hood, Brian L
 
<120>  ANTIBODIES TO ENDOPLASMIN AND THEIR USE

<130>  8123-85229-02

<150>  US 61/355,516
<151>  2010-06-16

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met Glu Thr His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  2
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Ile Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  3
<211>  1332
<212>  DNA
<213>  Homo sapiens

<400>  3
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatgcta tgcattgggt gcgccaggcc      120

cccggacaaa ggcttgagtg gatgggatgg atcaacgctg gcaatggtaa cacaaaatat      180

tcacagaagt tccagggcag agtcaccatt accagggaca catccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggccgtgt attactgtgc aagggcccat      300

tttgactact ggggccaagg taccctggtc accgtctcgg ctagcaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaat ga                                                         1332


<210>  4
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  4
gaaattgagc tcacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctacttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctccaac gttcggccaa      300

gggaccaagg tggagatcaa aacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                         642


<210>  5
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
            580                 585                 590         


Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
        595                 600                 605             


Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
    610                 615                 620                 


Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
625                 630                 635                 640 


Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly 
                645                 650                 655     


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp 
            660                 665                 670         


Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
        675                 680                 685             


Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
    690                 695                 700                 


Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr 
705                 710                 715                 720 


Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                725                 730                 735     


Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp 
            740                 745                 750         


Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu 
        755                 760                 765             


Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val 
    770                 775                 780                 


Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Lys 
785                 790                 795                 800 


Asp Glu Leu 
            


<210>  6
<211>  2780
<212>  DNA
<213>  Homo sapiens

<400>  6
gtgggcggac cgcgcggctg gaggtgtgag gatccgaacc caggggtggg gggtggaggc       60

ggctcctgcg atcgaagggg acttgagact caccggccgc acgccatgag ggccctgtgg      120

gtgctgggcc tctgctgcgt cctgctgacc ttcgggtcgg tcagagctga cgatgaagtt      180

gatgtggatg gtacagtaga agaggatctg ggtaaaagta gagaaggatc aaggacggat      240

gatgaagtag tacagagaga ggaagaagct attcagttgg atggattaaa tgcatcacaa      300

ataagagaac ttagagagaa gtcggaaaag tttgccttcc aagccgaagt taacagaatg      360

atgaaactta tcatcaattc attgtataaa aataaagaga ttttcctgag agaactgatt      420

tcaaatgctt ctgatgcttt agataagata aggctaatat cactgactga tgaaaatgct      480

ctttctggaa atgaggaact aacagtcaaa attaagtgtg ataaggagaa gaacctgctg      540

catgtcacag acaccggtgt aggaatgacc agagaagagt tggttaaaaa ccttggtacc      600

atagccaaat ctgggacaag cgagttttta aacaaaatga ctgaagcaca ggaagatggc      660

cagtcaactt ctgaattgat tggccagttt ggtgtcggtt tctattccgc cttccttgta      720

gcagataagg ttattgtcac ttcaaaacac aacaacgata cccagcacat ctgggagtct      780

gactccaatg aattttctgt aattgctgac ccaagaggaa acactctagg acggggaacg      840

acaattaccc ttgtcttaaa agaagaagca tctgattacc ttgaattgga tacaattaaa      900

aatctcgtca aaaaatattc acagttcata aactttccta tttatgtatg gagcagcaag      960

actgaaactg ttgaggagcc catggaggaa gaagaagcag ccaaagaaga gaaagaagaa     1020

tctgatgatg aagctgcagt agaggaagaa gaagaagaaa agaaaccaaa gactaaaaaa     1080

gttgaaaaaa ctgtctggga ctgggaactt atgaatgata tcaaaccaat atggcagaga     1140

ccatcaaaag aagtagaaga agatgaatac aaagctttct acaaatcatt ttcaaaggaa     1200

agtgatgacc ccatggctta tattcacttt actgctgaag gggaagttac cttcaaatca     1260

attttatttg tacccacatc tgctccacgt ggtctgtttg acgaatatgg atctaaaaag     1320

agcgattaca ttaagctcta tgtgcgccgt gtattcatca cagacgactt ccatgatatg     1380

atgcctaaat acctcaattt tgtcaagggt gtggtggact cagatgatct ccccttgaat     1440

gtttcccgcg agactcttca gcaacataaa ctgcttaagg tgattaggaa gaagcttgtt     1500

cgtaaaacgc tggacatgat caagaagatt gctgatgata aatacaatga tactttttgg     1560

aaagaatttg gtaccaacat caagcttggt gtgattgaag accactcgaa tcgaacacgt     1620

cttgctaaac ttcttaggtt ccagtcttct catcatccaa ctgacattac tagcctagac     1680

cagtatgtgg aaagaatgaa ggaaaaacaa gacaaaatct acttcatggc tgggtccagc     1740

agaaaagagg ctgaatcttc tccatttgtt gagcgacttc tgaaaaaggg ctatgaagtt     1800

atttacctca cagaacctgt ggatgaatac tgtattcagg cccttcccga atttgatggg     1860

aagaggttcc agaatgttgc caaggaagga gtgaagttcg atgaaagtga gaaaactaag     1920

gagagtcgtg aagcagttga gaaagaattt gagcctctgc tgaattggat gaaagataaa     1980

gcccttaagg acaagattga aaaggctgtg gtgtctcagc gcctgacaga atctccgtgt     2040

gctttggtgg ccagccagta cggatggtct ggcaacatgg agagaatcat gaaagcacaa     2100

gcgtaccaaa cgggcaagga catctctaca aattactatg cgagtcagaa gaaaacattt     2160

gaaattaatc ccagacaccc gctgatcaga gacatgcttc gacgaattaa ggaagatgaa     2220

gatgataaaa cagttttgga tcttgctgtg gttttgtttg aaacagcaac gcttcggtca     2280

gggtatcttt taccagacac taaagcatat ggagatagaa tagaaagaat gcttcgcctc     2340

agtttgaaca ttgaccctga tgcaaaggtg gaagaagagc ccgaagaaga acctgaagag     2400

acagcagaag acacaacaga agacacagag caagacgaag atgaagaaat ggatgtggga     2460

acagatgaag aagaagaaac agcaaaggaa tctacagctg aaaaagatga attgtaaatt     2520

atactctcac catttggatc ctgtgtggag agggaatgtg aaatttacat catttctttt     2580

tgggagagac ttgttttgga tgccccctaa tccccttctc ccctgcactg taaaatgtgg     2640

gattatgggt cacaggaaaa agtgggtttt ttagttgaat tttttttaac attcctcatg     2700

aatgtaaatt tgtactattt aactgactat tcttgatgta aaatcttgtc atgtgtataa     2760

aaataaaaaa gatcccaaat                                                 2780


<210>  7
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu Asp Lys 
1               5                   10          


<210>  8
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
1               5                   10                  


