                         SEQUENCE LISTING

<110>  Wasserman, Heather
       Carlson, Tim
       Migone, Thi-Sau
       Devalaraja, Madhav
 
<120>  Use of B Lymphocyte Stimulator Protein Antagonists to Treat 
       Asthma and Other Allergic and Inflammatory Conditions of the 
       Respiratory System

<130>  708562 (PF624PCT)

<150>  61/488,730
<151>  2011-05-21

<150>  61/389,018
<151>  2010-10-01

<150>  61/356,485
<151>  2010-06-18

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  1100
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (147)..(1001)

<400>  1
aaattcagga taactctcct gaggggtgag ccaagccctg ccatgtagtg cacgcaggac       60

atcaacaaac acagataaca ggaaatgatc cattccctgt ggtcacttat tctaaaggcc      120

ccaaccttca aagttcaagt agtgat atg gat gac tcc aca gaa agg gag cag       173
                             Met Asp Asp Ser Thr Glu Arg Glu Gln          
                             1               5                            

tca cgc ctt act tct tgc ctt aag aaa aga gaa gaa atg aaa ctg aag        221
Ser Arg Leu Thr Ser Cys Leu Lys Lys Arg Glu Glu Met Lys Leu Lys           
10                  15                  20                  25            

gag tgt gtt tcc atc ctc cca cgg aag gaa agc ccc tct gtc cga tcc        269
Glu Cys Val Ser Ile Leu Pro Arg Lys Glu Ser Pro Ser Val Arg Ser           
                30                  35                  40                

tcc aaa gac gga aag ctg ctg gct gca acc ttg ctg ctg gca ctg ctg        317
Ser Lys Asp Gly Lys Leu Leu Ala Ala Thr Leu Leu Leu Ala Leu Leu           
            45                  50                  55                    

tct tgc tgc ctc acg gtg gtg tct ttc tac cag gtg gcc gcc ctg caa        365
Ser Cys Cys Leu Thr Val Val Ser Phe Tyr Gln Val Ala Ala Leu Gln           
        60                  65                  70                        

ggg gac ctg gcc agc ctc cgg gca gag ctg cag ggc cac cac gcg gag        413
Gly Asp Leu Ala Ser Leu Arg Ala Glu Leu Gln Gly His His Ala Glu           
    75                  80                  85                            

aag ctg cca gca gga gca gga gcc ccc aag gcc ggc ctg gag gaa gct        461
Lys Leu Pro Ala Gly Ala Gly Ala Pro Lys Ala Gly Leu Glu Glu Ala           
90                  95                  100                 105           

cca gct gtc acc gcg gga ctg aaa atc ttt gaa cca cca gct cca gga        509
Pro Ala Val Thr Ala Gly Leu Lys Ile Phe Glu Pro Pro Ala Pro Gly           
                110                 115                 120               

gaa ggc aac tcc agt cag aac agc aga aat aag cgt gcc gtt cag ggt        557
Glu Gly Asn Ser Ser Gln Asn Ser Arg Asn Lys Arg Ala Val Gln Gly           
            125                 130                 135                   

cca gaa gaa aca gtc act caa gac tgc ttg caa ctg att gca gac agt        605
Pro Glu Glu Thr Val Thr Gln Asp Cys Leu Gln Leu Ile Ala Asp Ser           
        140                 145                 150                       

gaa aca cca act ata caa aaa gga tct tac aca ttt gtt cca tgg ctt        653
Glu Thr Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe Val Pro Trp Leu           
    155                 160                 165                           

ctc agc ttt aaa agg gga agt gcc cta gaa gaa aaa gag aat aaa ata        701
Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys Glu Asn Lys Ile           
170                 175                 180                 185           

ttg gtc aaa gaa act ggt tac ttt ttt ata tat ggt cag gtt tta tat        749
Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly Gln Val Leu Tyr           
                190                 195                 200               

act gat aag acc tac gcc atg gga cat cta att cag agg aag aag gtc        797
Thr Asp Lys Thr Tyr Ala Met Gly His Leu Ile Gln Arg Lys Lys Val           
            205                 210                 215                   

cat gtc ttt ggg gat gaa ttg agt ctg gtg act ttg ttt cga tgt att        845
His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys Ile           
        220                 225                 230                       

caa aat atg cct gaa aca cta ccc aat aat tcc tgc tat tca gct ggc        893
Gln Asn Met Pro Glu Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly           
    235                 240                 245                           

att gca aaa ctg gaa gaa gga gat gaa ctc caa ctt gca ata cca aga        941
Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu Ala Ile Pro Arg           
250                 255                 260                 265           

gaa aat gca caa ata tca ctg gat gga gat gtc aca ttt ttt ggt gca        989
Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp Val Thr Phe Phe Gly Ala           
                270                 275                 280               

ttg aaa ctg ctg tgacctactt acaccatgtc tgtagctatt ttcctccctt           1041
Leu Lys Leu Leu                                                           
            285                                                           

tctctgtacc tctaagaaga aagaatctaa ctgaaaatac caaaaaaaaa aaaaaaaaa      1100


<210>  2
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
    130                 135                 140                 


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
145                 150                 155                 160 


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
                165                 170                 175     


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
            180                 185                 190         


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
        195                 200                 205             


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
    210                 215                 220                 


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
225                 230                 235                 240 


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
                245                 250                 255     


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
            260                 265                 270         


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
        275                 280                 285 


<210>  3
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  4
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Arg Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  5
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg 
1               5                   10                  15      


Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu 
            20                  25                  30          


Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro 
        35                  40                  45              


Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala Asp Pro Gly Ala Gln 
    50                  55                  60                  


Ala Gln Gln Gly Leu Gly Phe Gln Lys Leu Pro Glu Glu Glu Pro Glu 
65                  70                  75                  80  


Thr Asp Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
                85                  90                  95      


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
            100                 105                 110         


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
        115                 120                 125             


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
    130                 135                 140                 


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
145                 150                 155                 160 


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
                165                 170                 175     


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
            180                 185                 190         


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
        195                 200                 205             


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
    210                 215                 220                 


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
225                 230                 235                 240 


Val Met Val Gly 
                


<210>  6
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 
        115                 120                 125             


Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 
    130                 135                 140                 


Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 
145                 150                 155                 160 


Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 
                165                 170                 175     


Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 
            180                 185                 190         


Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 
        195                 200                 205             


His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 
    210                 215                 220                 


Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 
225                 230                 235                 240 


Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 
                245                 250                 255     


Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 
            260                 265                 270         


Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
        275                 280     


<210>  7
<211>  338
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (68)..(72)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (213)..(213)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (256)..(256)
<223>  n equals a, t, g or c

<220>
<221>  misc_feature
<222>  (298)..(298)
<223>  n equals a, t, g or c

<220>
<221>  misc_feature
<222>  (301)..(301)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (321)..(321)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (336)..(336)
<223>  n equals a, t, g, or c

<400>  7
aggntaactc tcctgagggg tgagccaagc cctgccatgt agtgcacgca ggacatcanc       60

aaacacannn nncaggaaat aatccattcc ctgtggtcac ttattctaaa ggccccaacc      120

ttcaaagttc aagtagtgat atggatgact ccacagaaag ggagcagtca cgccttactt      180

cttgccttaa gaaaagagaa gaaatgaaac tgnaaggagt gtgtttccat cctcccacgg      240

aaggaaagcc cctctntccg atcctccaaa gacggaaagc tgctggctgc aaccttgntg      300

ntggcattgt gttcttgctg nctcaaggtg gtgttntt                              338


<210>  8
<211>  509
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (209)..(209)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (315)..(315)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (322)..(322)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (325)..(325)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (334)..(334)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (343)..(343)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (347)..(347)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (351)..(351)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (356)..(356)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (409)..(410)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (416)..(416)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (422)..(422)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (424)..(424)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (426)..(427)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (429)..(429)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (431)..(431)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (433)..(433)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (438)..(439)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (443)..(444)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (446)..(447)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (449)..(450)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (452)..(453)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (458)..(458)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (461)..(462)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (466)..(466)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (469)..(469)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (471)..(472)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (474)..(474)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (478)..(481)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (496)..(496)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (498)..(498)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (504)..(504)
<223>  n equals a, t, g, or c

<400>  8
aattcggcan agnaaactgg ttactttttt atatatggtc aggttttata tactgataag       60

acctacgcca tgggacatct agttcagagg aagaaggtcc atgtctttgg ggatgaattg      120

agtctggtga ctttgtttcg atgtattcaa aatatgcctg aaacactacc caataattcc      180

tgctattcag ctggcattgc aaaactggna ggaaggagat gaactccaac ttgcaatacc      240

aggggaaaat gcacaattat cactgggatg gagatgttca cattttttgg gtgccattga      300

aactgctgtg acctncttac ancangtgct gttngctatt ttncctncct nttctntggt      360

aacctcttag gaaggaagga ttcttaactg ggaaataacc caaaaaaann ttaaangggt      420

angngnnana ngnggggnng ttnncnngnn gnnttttngg nntatnttnt nntngggnnn      480

ngtaaaaatg gggccnangg gggnttttt                                        509


<210>  9
<211>  497
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (168)..(168)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (213)..(213)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (288)..(288)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (325)..(325)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (346)..(346)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (406)..(406)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (415)..(415)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (419)..(419)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (437)..(437)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (442)..(442)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (467)..(467)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (473)..(473)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (476)..(476)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (481)..(481)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (483)..(484)
<223>  n equals a, t, g, or c

<220>
<221>  misc_feature
<222>  (494)..(494)
<223>  n equals a, t, g, or c

<400>  9
aattcggcac gagcaaggcc ggcctggagg aagctccagc tgtcaccgcg ggactgaaaa       60

tctttgaacc accagctcca ggagaaggca actccagtca gaacagcaga aataagcgtg      120

ccgttcaggg tccagaagaa acagtcactc aagactgctt gcaactgntt gcagacagtg      180

aaacaccaac tatacaaaaa ggctcccttc tgntgccaca tttgggccaa ggaatggaga      240

gatttcttcg tctggaaaca ttttgccaaa ctcttcagat actctttnct ctctgggaat      300

caaaggaaaa tctctactta gattnacaca tttgttccca tgggtntctt aagttttaaa      360

aggggagtgc ccttaggagg aaaaggggat aaatattggc caaggnactg gttantttnt      420

aaatatggtc aggtttntat anctggtagg cctcgccatg ggcattnatt canggngagg      480

ncnntctttt gggntga                                                     497


<210>  10
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neutrokine-alpha forward primer containing BamHI restriction site

<400>  10
gtgggatcca gcctccgggc agagctg                                           27


<210>  11
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neutrokine-alpha rev primer HindIII site and two stop codons

<400>  11
gtgaagcttt tattacagca gtttcaatgc acc                                    33


<210>  12
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neutrokine-alpha forward primer containing BspHI restriction site

<400>  12
gtgtcatgag cctccgggca gagctg                                            26


<210>  13
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neutrokine-alpha rev primer HindIII site and two stop codons

<400>  13
gtgaagcttt tattacagca gtttcaatgc acc                                    33


<210>  14
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neutrokine-alpha forward primer containing BamHI restriction site

<400>  14
gtgggatccc cgggcagagc tgcagggc                                          28


<210>  15
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neutrokine-alpha rev primer BamHI site and two stop codons

<400>  15
gtgggatcct tattacagca gtttcaatgc acc                                    33


<210>  16
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neutrokine-alpha fwd primer BamHI, Kozak, AUG, and IL-6

<400>  16
gcgggatccg ccaccatgaa ctccttctcc acaagcgcct tcggtccagt tgccttctcc       60

ctggggctgc tcctggtgtt gcctgctgcc ttccctgccc cagttgtgag acaaggggac      120

ctggccagc                                                              129


<210>  17
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neutrokine-alpha reverse primer containing BamHI site

<400>  17
gtgggatcct tacagcagtt tcaatgcacc                                        30


<210>  18
<211>  903
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(798)

<400>  18
atg gat gac tcc aca gaa agg gag cag tca cgc ctt act tct tgc ctt         48
Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu           
1               5                   10                  15                

aag aaa aga gaa gaa atg aaa ctg aag gag tgt gtt tcc atc ctc cca         96
Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro           
            20                  25                  30                    

cgg aag gaa agc ccc tct gtc cga tcc tcc aaa gac gga aag ctg ctg        144
Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu           
        35                  40                  45                        

gct gca acc ttg ctg ctg gca ctg ctg tct tgc tgc ctc acg gtg gtg        192
Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val           
    50                  55                  60                            

tct ttc tac cag gtg gcc gcc ctg caa ggg gac ctg gcc agc ctc cgg        240
Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg           
65                  70                  75                  80            

gca gag ctg cag ggc cac cac gcg gag aag ctg cca gca gga gca gga        288
Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly           
                85                  90                  95                

gcc ccc aag gcc ggc ctg gag gaa gct cca gct gtc acc gcg gga ctg        336
Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu           
            100                 105                 110                   

aaa atc ttt gaa cca cca gct cca gga gaa ggc aac tcc agt cag aac        384
Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn           
        115                 120                 125                       

agc aga aat aag cgt gcc gtt cag ggt cca gaa gaa aca gga tct tac        432
Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Gly Ser Tyr           
    130                 135                 140                           

aca ttt gtt cca tgg ctt ctc agc ttt aaa agg gga agt gcc cta gaa        480
Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu           
145                 150                 155                 160           

gaa aaa gag aat aaa ata ttg gtc aaa gaa act ggt tac ttt ttt ata        528
Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile           
                165                 170                 175               

tat ggt cag gtt tta tat act gat aag acc tac gcc atg gga cat cta        576
Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu           
            180                 185                 190                   

att cag agg aag aag gtc cat gtc ttt ggg gat gaa ttg agt ctg gtg        624
Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val           
        195                 200                 205                       

act ttg ttt cga tgt att caa aat atg cct gaa aca cta ccc aat aat        672
Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn           
    210                 215                 220                           

tcc tgc tat tca gct ggc att gca aaa ctg gaa gaa gga gat gaa ctc        720
Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu           
225                 230                 235                 240           

caa ctt gca ata cca aga gaa aat gca caa ata tca ctg gat gga gat        768
Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp           
                245                 250                 255               

gtc aca ttt ttt ggt gca ttg aaa ctg ctg tgacctactt acaccatgtc          818
Val Thr Phe Phe Gly Ala Leu Lys Leu Leu                                   
            260                 265                                       

tgtagctatt ttcctccctt tctctgtacc tctaagaaga aagaatctaa ctgaaaatac      878

caaaaaaaaa aaaaaaaaaa aaaaa                                            903


<210>  19
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Gly Ser Tyr 
    130                 135                 140                 


Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu 
145                 150                 155                 160 


Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile 
                165                 170                 175     


Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu 
            180                 185                 190         


Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val 
        195                 200                 205             


Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn 
    210                 215                 220                 


Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu 
225                 230                 235                 240 


Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp 
                245                 250                 255     


Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
            260                 265     


<210>  20
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  20

His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys Asp Asp 
1               5                   10                  15      


Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg Gly Arg 
            20                  25                  30          


Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly Val 
        35                  40                  45              


Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe Thr Met 
    50                  55                  60                  


Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe 
65                  70                  75                  80  


Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr Asn Ser 
                85                  90                  95      


Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile Leu Ser 
            100                 105                 110         


Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro His Gly 
        115                 120                 125             


Thr Phe Leu Gly Phe Val Lys Leu 
    130                 135     


<210>  21
<211>  462
<212>  DNA
<213>  Homo sapiens

<400>  21
atggctgttc agggtccgga agaaaccgtt actcaggact gccttcagct gatcgcagac       60

tctgaaactc cgaccatcca gaaaggttct tacacctttg ttccttggct gctttctttc      120

aaacgtggtt ctgccctgga agagaaagaa aacaaaatcc tggttaaaga aactggttac      180

ttctttatct acggtcaggt tctttacact gataagacct acgccatggg tcacctgatt      240

cagcgtaaga aagttcacgt tttcggtgac gagctgtctc tggttactct gtttcgctgc      300

attcagaaca tgccggaaac tcttcctaac aactcctgct actctgctgg catcgcaaaa      360

ctggaagagg gtgatgaact gcagctggca attcctcgtg aaaacgcaca aatttctctg      420

gacggtgatg taaccttctt tggtgcactg aaacttctgt aa                         462


<210>  22
<211>  1040
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(468)

<400>  22
cgc gtg gta gac ctc tca gct cct cct gca cca tgc ctg cct gga tgc         48
Arg Val Val Asp Leu Ser Ala Pro Pro Ala Pro Cys Leu Pro Gly Cys           
1               5                   10                  15                

cgc cat tct caa cat gat gat aat gga atg aac ctc aga aac aga act         96
Arg His Ser Gln His Asp Asp Asn Gly Met Asn Leu Arg Asn Arg Thr           
            20                  25                  30                    

tac aca ttt gtt cca tgg ctt ctc agc ttt aaa aga gga aat gcc ttg        144
Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu           
        35                  40                  45                        

gag gag aaa gag aac aaa ata gtg gtg agg caa aca ggc tat ttc ttc        192
Glu Glu Lys Glu Asn Lys Ile Val Val Arg Gln Thr Gly Tyr Phe Phe           
    50                  55                  60                            

atc tac agc cag gtt cta tac acg gac ccc atc ttt gct atg ggt cat        240
Ile Tyr Ser Gln Val Leu Tyr Thr Asp Pro Ile Phe Ala Met Gly His           
65                  70                  75                  80            

gtc atc cag agg aag aaa gta cac gtc ttt ggg gac gag ctg agc ctg        288
Val Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu           
                85                  90                  95                

gtg acc ctg ttc cga tgt att cag aat atg ccc aaa aca ctg ccc aac        336
Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Lys Thr Leu Pro Asn           
            100                 105                 110                   

aat tcc tgc tac tcg gct ggc atc gcg agg ctg gaa gaa gga gat gag        384
Asn Ser Cys Tyr Ser Ala Gly Ile Ala Arg Leu Glu Glu Gly Asp Glu           
        115                 120                 125                       

att cag ctt gca att cct cgg gag aat gca cag att tca cgc aac gga        432
Ile Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly           
    130                 135                 140                           

gac gac acc ttc ttt ggt gcc cta aaa ctg ctg taa ctcacttgct             478
Asp Asp Thr Phe Phe Gly Ala Leu Lys Leu Leu                               
145                 150                 155                               

ggagtgcgtg atccccttcc ctcgtcttct ctgtacctcc gagggagaaa cagacgactg      538

gaaaaactaa aagatgggga aagccgtcag cgaaagtttt ctcgtgaccc gttgaatctg      598

atccaaacca ggaaatataa cagacagcca caaccgaagt gtgccatgtg agttatgaga      658

aacggagccc gcgctcagaa agaccggatg aggaagaccg ttttctccag tcctttgcca      718

acacgcaccg caaccttgct ttttgccttg ggtgacacat gttcagaatg cagggagatt      778

tccttgtttt gcgatttgcc atgagaagag ggcccacaac tgcaggtcac tgaagcattc      838

acgctaagtc tcaggattta ctctcccttc tcatgctaag tacacacacg ctcttttcca      898

ggtaatacta tgggatacta tggaaaggtt gtttgttttt aaatctagaa gtcttgaact      958

ggcaatagac aaaaatcctt ataaattcaa gtgtaaaata aacttaatta aaaaggttta     1018

agtgtgaaaa aaaaaaaaaa aa                                              1040


<210>  23
<211>  155
<212>  PRT
<213>  Mus musculus

<400>  23

Arg Val Val Asp Leu Ser Ala Pro Pro Ala Pro Cys Leu Pro Gly Cys 
1               5                   10                  15      


Arg His Ser Gln His Asp Asp Asn Gly Met Asn Leu Arg Asn Arg Thr 
            20                  25                  30          


Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu 
        35                  40                  45              


Glu Glu Lys Glu Asn Lys Ile Val Val Arg Gln Thr Gly Tyr Phe Phe 
    50                  55                  60                  


Ile Tyr Ser Gln Val Leu Tyr Thr Asp Pro Ile Phe Ala Met Gly His 
65                  70                  75                  80  


Val Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu 
                85                  90                  95      


Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Lys Thr Leu Pro Asn 
            100                 105                 110         


Asn Ser Cys Tyr Ser Ala Gly Ile Ala Arg Leu Glu Glu Gly Asp Glu 
        115                 120                 125             


Ile Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly 
    130                 135                 140                 


Asp Asp Thr Phe Phe Gly Ala Leu Lys Leu Leu 
145                 150                 155 


<210>  24
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neutrokine-alpha primer

<400>  24
ccaccagctc caggagaagg caactc                                            26


<210>  25
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neutrokine-alpha probe

<400>  25
accgcgggac tgaaaatct                                                    19


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neutrokine-alpha primer

<400>  26
cacgcttatt tctgctgttc tga                                               23


<210>  27
<211>  657
<212>  DNA
<213>  Macaca irus

<400>  27
taccaggtgg cggccgtgca aggggacctg gccagcctcc gggcagagct gcagggccac       60

cacgcggaga agctgccagc aagagcaaga gcccccaagg ccggtctggg ggaagctcca      120

gctgtcaccg caggactgaa aatctttgaa ccaccagctc caggagaagg caactccagt      180

cagagcagca gaaataagcg tgctattcag ggtgcagaag aaacagtcat tcaagactgc      240

ttgcaactga ttgcagacag tgaaacacca actatacaaa aaggatctta cacatttgtt      300

ccatggcttc tcagctttaa aaggggaagt gccctagaag aaaaagagaa taaaatattg      360

gtcaaagaaa ctggttactt ttttatatat ggtcaggttt tatacactga taagacctat      420

gccatgggac atctaattca gaggaaaaaa gtccatgtct ttggggatga attgagtctg      480

gtgactttgt ttcgatgtat tcaaaatatg cctgaaacac tacccaataa ttcctgctat      540

tcagctggca ttgcaaaact ggaagaagga gatgaacttc aacttgcaat accacgagaa      600

aatgcacaaa tatcactgga tggagatgtc acattttttg gtgccctcaa actgctg         657


<210>  28
<211>  219
<212>  PRT
<213>  Macaca irus

<400>  28

Tyr Gln Val Ala Ala Val Gln Gly Asp Leu Ala Ser Leu Arg Ala Glu 
1               5                   10                  15      


Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Arg Ala Arg Ala Pro 
            20                  25                  30          


Lys Ala Gly Leu Gly Glu Ala Pro Ala Val Thr Ala Gly Leu Lys Ile 
        35                  40                  45              


Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Ser Ser Arg 
    50                  55                  60                  


Asn Lys Arg Ala Ile Gln Gly Ala Glu Glu Thr Val Ile Gln Asp Cys 
65                  70                  75                  80  


Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser 
                85                  90                  95      


Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu 
            100                 105                 110         


Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe 
        115                 120                 125             


Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His 
    130                 135                 140                 


Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu 
145                 150                 155                 160 


Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn 
                165                 170                 175     


Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu 
            180                 185                 190         


Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly 
        195                 200                 205             


Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
    210                 215                 


<210>  29
<211>  657
<212>  DNA
<213>  Macaca mulatta (Rhesus Monkey)

<400>  29
taccaggtgg cggccgtgca aggggacctg gccagcctcc gggcagagct gcagagccac       60

cacgcggaga agctgccagc aagagcaaga gcccccaagg ccggtctggg ggaagctcca      120

gctgtcaccg cgggactgaa aatctttgaa ccaccagctc caggagaagg caactccagt      180

cagagcagca gaaataagcg tgctattcag ggtgcagaag aaacagtcat tcaagactgc      240

ttgcaactga ttgcagacag tgaaacacca actatacaaa aaggatctta cacatttgtt      300

ccatggcttc tcagctttaa aaggggaagt gccctagaag aaaaagagaa taaaatattg      360

gtcaaagaaa ctggttactt ttttatatat ggtcaggttt tatacactga taagacctat      420

gccatgggac atctaattca gaggaaaaaa gtccatgtct ttggggatga attgagtctg      480

gtgactttgt ttcgatgtat tcaaaatatg cctgaaacac tacccaataa ttcctgctat      540

tcagctggca ttgcaaaact ggaagaaggg gatgaacttc aacttgcaat accacgagaa      600

aatgcacaaa tatcactgga tggagatgtc acattttttg gtgccctcaa actgctg         657


<210>  30
<211>  219
<212>  PRT
<213>  Macaca mulatta (Rhesus Monkey)

<400>  30

Tyr Gln Val Ala Ala Val Gln Gly Asp Leu Ala Ser Leu Arg Ala Glu 
1               5                   10                  15      


Leu Gln Ser His His Ala Glu Lys Leu Pro Ala Arg Ala Arg Ala Pro 
            20                  25                  30          


Lys Ala Gly Leu Gly Glu Ala Pro Ala Val Thr Ala Gly Leu Lys Ile 
        35                  40                  45              


Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Ser Ser Arg 
    50                  55                  60                  


Asn Lys Arg Ala Ile Gln Gly Ala Glu Glu Thr Val Ile Gln Asp Cys 
65                  70                  75                  80  


Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser 
                85                  90                  95      


Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu 
            100                 105                 110         


Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe 
        115                 120                 125             


Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His 
    130                 135                 140                 


Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu 
145                 150                 155                 160 


Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn 
                165                 170                 175     


Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu 
            180                 185                 190         


Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly 
        195                 200                 205             


Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
    210                 215                 


<210>  31
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neutrokine-alpha fwd primer PSC signal peptide C-terminus

<400>  31
ggtcgccgtt tctaacgcgg ccgttcaggg tccagaag                               38


<210>  32
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rev primer pA2GP vector and KpnI restriction site

<400>  32
ctggttcggc ccaaggtacc aagcttgtac cttagatctt ttctagatc                   49


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fwd primer for PSC baculovirus transfer plasmid pMGS12

<400>  33
ctggtagttc ttcggagtgt g                                                 21


<210>  34
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rev primer for PSC baculovirus transfer plasmid pMGS12

<400>  34
cgcgttagaa acggcgacc                                                    19


<210>  35
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neutrokine-alpha degenerate oligonucleotide forward primer


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n equals deoxyinosine or dideoxyinosine

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n equals deoxyinosine or dideoxyinosine

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n equals deoxyinosine or dideoxyinosine

<400>  35
taccagntgg cngccntgca ag                                                22


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neutrokine-alpha degenerate oligonucleotide reverse primer


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n equals deoxyinosine or dideoxyinosine

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n equals deoxyinosine or dideoxyinosine

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  n equals deoxyinosine or dideoxyinosine

<400>  36
gtnacagcag tttnanngca cc                                                22


<210>  37
<211>  867
<212>  DNA
<213>  Mus musculus

<400>  37
atggatgagt ctgcaaagac cctgccacca ccgtgcctct gtttttgctc cgagaaagga       60

gaagatatga aagtgggata tgatcccatc actccgcaga aggaggaggg tgcctggttt      120

gggatctgca gggatggaag gctgctggct gctaccctcc tgctggccct gttgtccagc      180

agtttcacag cgatgtcctt gtaccagttg gctgccttgc aagcagacct gatgaacctg      240

cgcatggagc tgcagagcta ccgaggttca gcaacaccag ccgccgcggg tgctccagag      300

ttgaccgctg gagtcaaact cctgacaccg gcagctcctc gaccccacaa ctccagccgc      360

ggccacagga acagacgcgc cttccaggga ccagaggaaa cagaacaaga tgtagacctc      420

tcagctcctc ctgcaccatg cctgcctgga tgccgccatt ctcaacatga tgataatgga      480

atgaacctca gaaacatcat tcaagactgt ctgcagctga ttgcagacag cgacacgccg      540

gccttggagg agaaagagaa caaaatagtg gtgaggcaaa caggctattt cttcatctac      600

agccaggttc tatacacgga ccccatcttt gctatgggtc atgtcatcca gaggaagaaa      660

gtacacgtct ttggggacga gctgagcctg gtgaccctgt tccgatgtat tcagaatatg      720

cccaaaacac tgcccaacaa ttcctgctac tcggctggca tcgcgaggct ggaagaagga      780

gatgagattc agcttgcaat tcctcgggag aatgcacaga tttcacgcaa cggagacgac      840

accttctttg gtgccctaaa actgctg                                          867


<210>  38
<211>  289
<212>  PRT
<213>  Mus musculus

<400>  38

Met Asp Glu Ser Ala Lys Thr Leu Pro Pro Pro Cys Leu Cys Phe Cys 
1               5                   10                  15      


Ser Glu Lys Gly Glu Asp Met Lys Val Gly Tyr Asp Pro Ile Thr Pro 
            20                  25                  30          


Gln Lys Glu Glu Gly Ala Trp Phe Gly Ile Cys Arg Asp Gly Arg Leu 
        35                  40                  45              


Leu Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Ser Ser Phe Thr Ala 
    50                  55                  60                  


Met Ser Leu Tyr Gln Leu Ala Ala Leu Gln Ala Asp Leu Met Asn Leu 
65                  70                  75                  80  


Arg Met Glu Leu Gln Ser Tyr Arg Gly Ser Ala Thr Pro Ala Ala Ala 
                85                  90                  95      


Gly Ala Pro Glu Leu Thr Ala Gly Val Lys Leu Leu Thr Pro Ala Ala 
            100                 105                 110         


Pro Arg Pro His Asn Ser Ser Arg Gly His Arg Asn Arg Arg Ala Phe 
        115                 120                 125             


Gln Gly Pro Glu Glu Thr Glu Gln Asp Val Asp Leu Ser Ala Pro Pro 
    130                 135                 140                 


Ala Pro Cys Leu Pro Gly Cys Arg His Ser Gln His Asp Asp Asn Gly 
145                 150                 155                 160 


Met Asn Leu Arg Asn Ile Ile Gln Asp Cys Leu Gln Leu Ile Ala Asp 
                165                 170                 175     


Ser Asp Thr Pro Ala Leu Glu Glu Lys Glu Asn Lys Ile Val Val Arg 
            180                 185                 190         


Gln Thr Gly Tyr Phe Phe Ile Tyr Ser Gln Val Leu Tyr Thr Asp Pro 
        195                 200                 205             


Ile Phe Ala Met Gly His Val Ile Gln Arg Lys Lys Val His Val Phe 
    210                 215                 220                 


Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met 
225                 230                 235                 240 


Pro Lys Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Arg 
                245                 250                 255     


Leu Glu Glu Gly Asp Glu Ile Gln Leu Ala Ile Pro Arg Glu Asn Ala 
            260                 265                 270         


Gln Ile Ser Arg Asn Gly Asp Asp Thr Phe Phe Gly Ala Leu Lys Leu 
        275                 280                 285             


Leu 
    


<210>  39
<211>  309
<212>  PRT
<213>  Mus musculus

<400>  39

Met Asp Glu Ser Ala Lys Thr Leu Pro Pro Pro Cys Leu Cys Phe Cys 
1               5                   10                  15      


Ser Glu Lys Gly Glu Asp Met Lys Val Gly Tyr Asp Pro Ile Thr Pro 
            20                  25                  30          


Gln Lys Glu Glu Gly Ala Trp Phe Gly Ile Cys Arg Asp Gly Arg Leu 
        35                  40                  45              


Leu Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Ser Ser Phe Thr Ala 
    50                  55                  60                  


Met Ser Leu Tyr Gln Leu Ala Ala Leu Gln Ala Asp Leu Met Asn Leu 
65                  70                  75                  80  


Arg Met Glu Leu Gln Ser Tyr Arg Gly Ser Ala Thr Pro Ala Ala Ala 
                85                  90                  95      


Gly Ala Pro Glu Leu Thr Ala Gly Val Lys Leu Leu Thr Pro Ala Ala 
            100                 105                 110         


Pro Arg Pro His Asn Ser Ser Arg Gly His Arg Asn Arg Arg Ala Phe 
        115                 120                 125             


Gln Gly Pro Glu Glu Thr Glu Gln Asp Val Asp Leu Ser Ala Pro Pro 
    130                 135                 140                 


Ala Pro Cys Leu Pro Gly Cys Arg His Ser Gln His Asp Asp Asn Gly 
145                 150                 155                 160 


Met Asn Leu Arg Asn Ile Ile Gln Asp Cys Leu Gln Leu Ile Ala Asp 
                165                 170                 175     


Ser Asp Thr Pro Thr Ile Arg Lys Gly Thr Tyr Thr Phe Val Pro Trp 
            180                 185                 190         


Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys Glu Asn Lys 
        195                 200                 205             


Ile Val Val Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser Gln Val Leu 
    210                 215                 220                 


Tyr Thr Asp Pro Ile Phe Ala Met Gly His Val Ile Gln Arg Lys Lys 
225                 230                 235                 240 


Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys 
                245                 250                 255     


Ile Gln Asn Met Pro Lys Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala 
            260                 265                 270         


Gly Ile Ala Arg Leu Glu Glu Gly Asp Glu Ile Gln Leu Ala Ile Pro 
        275                 280                 285             


Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr Phe Phe Gly 
    290                 295                 300                 


Ala Leu Lys Leu Leu 
305                 


<210>  40
<211>  290
<212>  PRT
<213>  Mus musculus

<400>  40

Met Asp Glu Ser Ala Lys Thr Leu Pro Pro Pro Cys Leu Cys Phe Cys 
1               5                   10                  15      


Ser Glu Lys Gly Glu Asp Met Lys Val Gly Tyr Asp Pro Ile Thr Pro 
            20                  25                  30          


Gln Lys Glu Glu Gly Ala Trp Phe Gly Ile Cys Arg Asp Gly Arg Leu 
        35                  40                  45              


Leu Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Ser Ser Phe Thr Ala 
    50                  55                  60                  


Met Ser Leu Tyr Gln Leu Ala Ala Leu Gln Ala Asp Leu Met Asn Leu 
65                  70                  75                  80  


Arg Met Glu Leu Gln Ser Tyr Arg Gly Ser Ala Thr Pro Ala Ala Ala 
                85                  90                  95      


Gly Ala Pro Glu Leu Thr Ala Gly Val Lys Leu Leu Thr Pro Ala Ala 
            100                 105                 110         


Pro Arg Pro His Asn Ser Ser Arg Gly His Arg Asn Arg Arg Ala Phe 
        115                 120                 125             


Gln Gly Pro Glu Glu Thr Glu Gln Asp Val Asp Leu Ser Ala Pro Pro 
    130                 135                 140                 


Ala Pro Cys Leu Pro Gly Cys Arg His Ser Gln His Asp Asp Asn Gly 
145                 150                 155                 160 


Met Asn Leu Arg Asn Arg Thr Tyr Thr Phe Val Pro Trp Leu Leu Ser 
                165                 170                 175     


Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys Glu Asn Lys Ile Val Val 
            180                 185                 190         


Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser Gln Val Leu Tyr Thr Asp 
        195                 200                 205             


Pro Ile Phe Ala Met Gly His Val Ile Gln Arg Lys Lys Val His Val 
    210                 215                 220                 


Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn 
225                 230                 235                 240 


Met Pro Lys Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala 
                245                 250                 255     


Arg Leu Glu Glu Gly Asp Glu Ile Gln Leu Ala Ile Pro Arg Glu Asn 
            260                 265                 270         


Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr Phe Phe Gly Ala Leu Lys 
        275                 280                 285             


Leu Leu 
    290 


<210>  41
<211>  152
<212>  PRT
<213>  Rattus sp

<400>  41

Ala Phe Gln Gly Pro Glu Glu Thr Val Ile Gln Asp Cys Leu Gln Leu 
1               5                   10                  15      


Ile Ala Asp Ser Asn Thr Pro Thr Ile Arg Lys Gly Thr Tyr Thr Phe 
            20                  25                  30          


Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys 
        35                  40                  45              


Glu Asn Lys Ile Val Val Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser 
    50                  55                  60                  


Gln Val Leu Tyr Thr Asp Pro Ile Phe Ala Met Gly His Val Ile Gln 
65                  70                  75                  80  


Arg Lys Lys Ile His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu 
                85                  90                  95      


Phe Arg Cys Ile Gln Asn Met Pro Lys Thr Leu Pro Asn Asn Ser Cys 
            100                 105                 110         


Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Val Gln Leu 
        115                 120                 125             


Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr 
    130                 135                 140                 


Phe Phe Gly Ala Leu Lys Leu Leu 
145                 150         


<210>  42
<211>  165
<212>  PRT
<213>  Rattus sp

<400>  42

Ala Phe Gln Gly Pro Glu Glu Thr Glu Gln Asp Val Asp Leu Ser Ala 
1               5                   10                  15      


Thr Pro Val Pro Ser Leu Pro Gly Asn Cys His Ala Ser His His Asp 
            20                  25                  30          


Glu Asn Gly Leu Asn Leu Arg Thr Arg Thr Tyr Thr Phe Val Pro Trp 
        35                  40                  45              


Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys Glu Asn Lys 
    50                  55                  60                  


Ile Val Val Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser Gln Val Leu 
65                  70                  75                  80  


Tyr Thr Asp Pro Ile Phe Ala Met Gly His Val Ile Gln Arg Lys Lys 
                85                  90                  95      


Ile His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys 
            100                 105                 110         


Ile Gln Asn Met Pro Lys Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala 
        115                 120                 125             


Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Ile Gln Leu Ala Ile Pro 
    130                 135                 140                 


Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr Phe Phe Gly 
145                 150                 155                 160 


Ala Leu Lys Leu Leu 
                165 


<210>  43
<211>  184
<212>  PRT
<213>  Rattus sp

<400>  43

Ala Phe Gln Gly Pro Glu Glu Thr Glu Gln Asp Val Asp Leu Ser Ala 
1               5                   10                  15      


Thr Pro Ala Pro Ser Leu Pro Gly Asn Cys His Ala Ser His His Asp 
            20                  25                  30          


Glu Asn Gly Leu Asn Leu Arg Thr Ile Ile Gln Asp Cys Leu Gln Leu 
        35                  40                  45              


Ile Ala Asp Ser Asn Thr Pro Thr Ile Arg Lys Gly Thr Tyr Thr Phe 
    50                  55                  60                  


Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys 
65                  70                  75                  80  


Glu Asn Lys Ile Val Val Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser 
                85                  90                  95      


Gln Val Leu Tyr Thr Asp Pro Ile Phe Ala Met Gly His Val Ile Gln 
            100                 105                 110         


Arg Lys Lys Ile His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu 
        115                 120                 125             


Phe Arg Cys Ile Gln Asn Met Pro Lys Thr Leu Pro Asn Asn Ser Cys 
    130                 135                 140                 


Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Ile Gln Leu 
145                 150                 155                 160 


Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr 
                165                 170                 175     


Phe Phe Gly Ala Leu Lys Leu Leu 
            180                 


<210>  44
<211>  133
<212>  PRT
<213>  Rattus sp

<400>  44

Ala Phe Gln Gly Pro Glu Glu Thr Gly Thr Tyr Thr Phe Val Pro Trp 
1               5                   10                  15      


Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys Glu Asn Lys 
            20                  25                  30          


Ile Val Val Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser Gln Val Leu 
        35                  40                  45              


Tyr Thr Asp Pro Ile Phe Ala Met Gly His Val Ile Gln Arg Lys Lys 
    50                  55                  60                  


Ile His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys 
65                  70                  75                  80  


Ile Gln Asn Met Pro Lys Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala 
                85                  90                  95      


Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Ile Gln Leu Ala Ile Pro 
            100                 105                 110         


Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr Phe Phe Gly 
        115                 120                 125             


Ala Leu Lys Leu Leu 
    130             


<210>  45
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Leu Gln Asn Ser Ala Val Leu Leu Leu Leu Val Ile Ser Ala Ser 
1               5                   10                  15      


Ala 
    


<210>  46
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus signal sequence

<400>  46

Met Pro Thr Trp Ala Trp Trp Leu Phe Leu Val Leu Leu Leu Ala Leu 
1               5                   10                  15      


Trp Ala Pro Ala Arg Gly 
            20          


<210>  47
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          


Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              


Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  


Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  


Gln Ser Leu Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 
                85                  90                  95      


Gly Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 
            100                 105                 110         


Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 
        115                 120                 125             


Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 
    130                 135                 140                 


Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala 
145                 150                 155                 160 


Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe 
                165                 170                 175     


Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr 
            180                 185                 190         


Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 
        195                 200                 205             


Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 
    210                 215                 220                 


Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 
225                 230                 235                 240 


His Gly Thr Phe Leu Gly Phe Val Lys Leu 
                245                 250 


<210>  48
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  48
cagactggat ccgccaccat ggatgactcc acagaaag                               38


<210>  49
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer

<400>  49
cagactggta ccgtcctgcg tgcactacat ggc                                    33


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer

<400>  50
tggtgtcttt ctaccaggtg g                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  51
tttcttctgg accctgaacg g                                                 21


<210>  52
<211>  4458
<212>  DNA
<213>  Artificial

<220>
<223>  pML124

<400>  52
gaattcaact tctccatact ttggataagg aaatacagac atgaaaaatc tcattgctga       60

gttgttattt aagcttgccc aaaaagaaga agagtcgaat gaactgtgtg cgcaggtaga      120

agctttggag attatcgtca ctgcaatgct tcgcaatatg gcgcaaaatg accaacagcg      180

gttgattgat caggtagagg gggcgctgta cgaggtaaag cccgatgcca gcattcctga      240

cgacgatacg gagctgctgc gcgattacgt aaagaagtta ttgaagcatc ctcgtcagta      300

aaaagttaat cttttcaaca gctgtcataa agttgtcacg gccgagactt atagtcgctt      360

tgtttttatt ttttaatgta tttgtaacta gtacgcaagt tcacgtaaag gaagtatctc      420

atatgcagat cttcgtgtaa accggtaccg gcaaaaccat cactctagaa gtggatcctc      480

tacgccggac gcatcgtggc cggcatcacc ggcgccacag gtgcggttgc tggcgcctat      540

atcgccgaca tcaccgatgg ggaagatcgg gctcgccact tcgggctcat gagcgcttgt      600

ttcggcgtgg gtatggtggc aggccccgtg gccgggggac tgttgggcgc catctccttg      660

catgcaccat tccttgcggc ggcggtgctc aacggcctca acctactact gggctgcttc      720

ctaatgcagg agtcgcataa gggagagcgt cgaccgatgc ccttgagagc cttcaaccca      780

gtcagctcct tccggtgggc gcggggcatg actatcgtcg ccgcacttat gactgtcttc      840

tttatcatgc aactcgtagg acaggtgccg gcagcgctct gggtcatttt cggcgaggac      900

cgctttcgct ggagcgcgac gatgatcggc ctgtcgcttg cggtattcgg aatcttgcac      960

gccctcgctc aagccttcgt cactggtccc gccaccaaac gtttcggcga gaagcaggcc     1020

attatcgccg gcatggcggc cgacgcgctg ggctacgtct tgctggcgtt cgcgacgcga     1080

ggctggatgg ccttccccat tatgattctt ctcgcttccg gcggcatcgg gatgcccgcg     1140

ttgcaggcca tgctgtccag gcaggtagat gacgaccatc agggacagct tcaaggatcg     1200

ctcgcggctc ttaccagcct aacttcgatc actggaccgc tgatcgtcac ggcgatttat     1260

gccgcctcgg cgagcacatg gaacgggttg gcatggattg taggcgccgc cctatacctt     1320

gtctgcctcc ccgcgttgcg tcgcggtgca tggagccggg ccacctcgac ctgaatggaa     1380

gccggcggca cctcgctaac ggattcacca ctccaagaat tggagccaat caattcttgc     1440

ggagaactgt gaatgcgcaa accaaccctt ggcagaacat atccatcgcg tccgccatct     1500

ccagcagccg cacgcggcgc atctcgggca gcgttgggtc ctggccacgg gtgcgcatga     1560

tcgtgctcct gtcgttgagg acccggctag gctggcgggg ttgccttact ggttagcaga     1620

atgaatcacc gatacgcgag cgaacgtgaa gcgactgctg ctgcaaaacg tctgcgacct     1680

gagcaacaac atgaatggtc ttcggtttcc gtgtttcgta aagtctggaa acgcggaagt     1740

cagcgccctg caccattatg ttccggatct gcatcgcagg atgctgctgg ctaccctgtg     1800

gaacacctac atctgtatta acgaagcgct ggcattgacc ctgagtgatt tttctctggt     1860

cccgccgcat ccataccgcc agttgtttac cctcacaacg ttccagtaac cgggcatgtt     1920

catcatcagt aacccgtatc gtgagcatcc tctctcgttt catcggtatc attaccccca     1980

tgaacagaaa tcccccttac acggaggcat cagtgaccaa acaggaaaaa accgccctta     2040

acatggcccg ctttatcaga agccagacat taacgcttct ggagaaactc aacgagctgg     2100

acgcggatga acaggcagac atctgtgaat cgcttcacga ccacgctgat gagctttacc     2160

gcagctgcct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     2220

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     2280

cagcgggtgt tggcgggtgt cggggcgcag ccatgaccca gtcacgtagc gatagcggag     2340

tgtatactgg cttaactatg cggcatcaga gcagattgta ctgagagtgc accatatatg     2400

cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct     2460

tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac     2520

tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga     2580

gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat     2640

aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac     2700

ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct     2760

gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg     2820

ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg     2880

ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt     2940

cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg     3000

attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac     3060

ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga     3120

aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt     3180

gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt     3240

tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga     3300

ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc     3360

taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct     3420

atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata     3480

actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca     3540

cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga     3600

agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga     3660

gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctgc aggcatcgtg     3720

gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga     3780

gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt     3840

gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct     3900

cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca     3960

ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaac acgggataat     4020

accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga     4080

aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc     4140

aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg     4200

caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc     4260

ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt     4320

gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca     4380

cctgacgtct aagaaaccat tattatcatg acattaacct ataaaaatag gcgtatcacg     4440

aggccctttc gtcttcaa                                                   4458


<210>  53
<211>  4980
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pML124:MBPss-BLyS

<400>  53
gaattcaact tctccatact ttggataagg aaatacagac atgaaaaatc tcattgctga       60

gttgttattt aagcttgccc aaaaagaaga agagtcgaat gaactgtgtg cgcaggtaga      120

agctttggag attatcgtca ctgcaatgct tcgcaatatg gcgcaaaatg accaacagcg      180

gttgattgat caggtagagg gggcgctgta cgaggtaaag cccgatgcca gcattcctga      240

cgacgatacg gagctgctgc gcgattacgt aaagaagtta ttgaagcatc ctcgtcagta      300

aaaagttaat cttttcaaca gctgtcataa agttgtcacg gccgagactt atagtcgctt      360

tgtttttatt ttttaatgta tttgtaacta gtacgcaagt tcacgtaaag gaagtatctc      420

atatgaaaat aaaaacaggt gcacgcatcc tcgcattatc cgcattaacg acgatgatgt      480

tttccgcctc ggctctcgcc gctgttcagg gtccggaaga aaccgttact caggactgcc      540

ttcagctgat cgcagactct gaaactccga ccatccagaa aggttcttac acctttgttc      600

cttggctgct ttctttcaaa cgtggttctg ccctggaaga gaaagaaaac aaaatcctgg      660

ttaaagaaac tggttacttc tttatctacg gtcaggttct ttacactgat aagacctacg      720

ccatgggtca cctgattcag cgtaagaaag ttcacgtttt cggtgacgag ctgtctctgg      780

ttactctgtt tcgctgcatt cagaacatgc cggaaactct tcctaacaac tcctgctact      840

ctgctggcat cgcaaaactg gaagagggtg atgaactgca gctggcaatt cctcgtgaaa      900

acgcacaaat ttctctggac ggtgatgtaa ccttctttgg tgcactgaaa cttctgtaat      960

aataaggtac cggcaaaacc atcactctag aagtggatcc tctacgccgg acgcatcgtg     1020

gccggcatca ccggcgccac aggtgcggtt gctggcgcct atatcgccga catcaccgat     1080

ggggaagatc gggctcgcca cttcgggctc atgagcgctt gtttcggcgt gggtatggtg     1140

gcaggccccg tggccggggg actgttgggc gccatctcct tgcatgcacc attccttgcg     1200

gcggcggtgc tcaacggcct caacctacta ctgggctgct tcctaatgca ggagtcgcat     1260

aagggagagc gtcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     1320

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     1380

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     1440

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     1500

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     1560

gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc     1620

attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc     1680

aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc     1740

ctaacttcga tcactggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca     1800

tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg     1860

cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta     1920

acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc     1980

aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc     2040

gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga     2100

ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg     2160

agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg     2220

tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta     2280

tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat     2340

taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg     2400

ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta     2460

tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt     2520

acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca     2580

gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag     2640

acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt     2700

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     2760

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     2820

gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta     2880

tgcggcatca gagcagattg tactgagagt gcaccatata tgcggtgtga aataccgcac     2940

agatgcgtaa ggagaaaata ccgcatcagg cgctcttccg cttcctcgct cactgactcg     3000

ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg     3060

ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag     3120

gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac     3180

gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga     3240

taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt     3300

accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc     3360

tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc     3420

cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta     3480

agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat     3540

gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca     3600

gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct     3660

tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt     3720

acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct     3780

cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc     3840

acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa     3900

acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta     3960

tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc     4020

ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat     4080

ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta     4140

tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt     4200

aatagtttgc gcaacgttgt tgccattgct gcaggcatcg tggtgtcacg ctcgtcgttt     4260

ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg     4320

ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc     4380

gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc     4440

gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg     4500

cggcgaccga gttgctcttg cccggcgtca acacgggata ataccgcgcc acatagcaga     4560

actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta     4620

ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct     4680

tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag     4740

ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca atattattga     4800

agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat     4860

aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgacgt ctaagaaacc     4920

attattatca tgacattaac ctataaaaat aggcgtatca cgaggccctt tcgtcttcaa     4980


<210>  54
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP signal sequence

<400>  54

Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr 
1               5                   10                  15      


Thr Met Met Phe Ser Ala Ser Ala Leu Ala 
            20                  25      


<210>  55
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBPss-Neutrokine-alpha

<400>  55

Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr 
1               5                   10                  15      


Thr Met Met Phe Ser Ala Ser Ala Leu Ala Ala Val Gln Gly Pro Glu 
            20                  25                  30          


Glu Thr Val Thr Gln Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr 
        35                  40                  45              


Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser 
    50                  55                  60                  


Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val 
65                  70                  75                  80  


Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp 
                85                  90                  95      


Lys Thr Tyr Ala Met Gly His Leu Ile Gln Arg Lys Lys Val His Val 
            100                 105                 110         


Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn 
        115                 120                 125             


Met Pro Glu Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala 
    130                 135                 140                 


Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn 
145                 150                 155                 160 


Ala Gln Ile Ser Leu Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys 
                165                 170                 175     


Leu Leu 
        


<210>  56
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  wild-type Shine Dalgarno box and its adjacent sequence

<400>  56
tttgtacatg gagaaaataa a                                                 21


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized Shine Dalgarno box and its adjacent sequence

<400>  57
cacgtaaagg aagtatctca t                                                 21


<210>  58
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  58

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ile Pro Arg Asn Thr Tyr Thr Thr Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Gly Gly Gly Tyr Trp Phe Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  59
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  59

Glu Leu Val Met Thr Gln Thr Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Gly Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Tyr 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Asp Asp Pro Met Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  60
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  60

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Met Phe Gly Thr Ala Lys Tyr Ser Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
    130                 135                 140                 


Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Val 
145                 150                 155                 160 


Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn 
            180                 185                 190         


Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
        195                 200                 205             


Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Glu Leu Thr Val Leu Gly 
                245                 


<210>  61
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  61

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Met Phe Gly Thr Ala Lys Tyr Ser Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Thr Ala Asp Glu Ser Thr Gly Thr Ala Ser 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Ala Leu Ser Pro 
            100                 105                 110         


Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
    130                 135                 140                 


Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Val 
145                 150                 155                 160 


Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn 
            180                 185                 190         


Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
        195                 200                 205             


Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ser Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Glu Leu Thr Val Leu Gly 
                245                 


<210>  62
<211>  882
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(882)

<400>  62
atg agt ggc ctg ggc cgg agc agg cga ggt ggc cgg agc cgt gtg gac         48
Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp           
1               5                   10                  15                

cag gag gag cgc ttt cca cag ggc ctg tgg acg ggg gtg gct atg aga         96
Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg           
            20                  25                  30                    

tcc tgc ccc gaa gag cag tac tgg gat cct ctg ctg ggt acc tgc atg        144
Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met           
        35                  40                  45                        

tcc tgc aaa acc att tgc aac cat cag agc cag cgc acc tgt gca gcc        192
Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala           
    50                  55                  60                            

ttc tgc agg tca ctc agc tgc cgc aag gag caa ggc aag ttc tat gac        240
Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp           
65                  70                  75                  80            

cat ctc ctg agg gac tgc atc agc tgt gcc tcc atc tgt gga cag cac        288
His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His           
                85                  90                  95                

cct aag caa tgt gca tac ttc tgt gag aac aag ctc agg agc cca gtg        336
Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val           
            100                 105                 110                   

aac ctt cca cca gag ctc agg aga cag cgg agt gga gaa gtt gaa aac        384
Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn           
        115                 120                 125                       

aat tca gac aac tcg gga agg tac caa gga ttg gag cac aga ggc tca        432
Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser           
    130                 135                 140                           

gaa gca agt cca gct ctc ccg ggg ctg aag ctg agt gca gat cag gtg        480
Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val           
145                 150                 155                 160           

gcc ctg gtc tac agc acg ctg ggg ctc tgc ctg tgt gcc gtc ctc tgc        528
Ala Leu Val Tyr Ser Thr Leu Gly Leu Cys Leu Cys Ala Val Leu Cys           
                165                 170                 175               

tgc ttc ctg gtg gcg gtg gcc tgc ttc ctc aag aag agg ggg gat ccc        576
Cys Phe Leu Val Ala Val Ala Cys Phe Leu Lys Lys Arg Gly Asp Pro           
            180                 185                 190                   

tgc tcc tgc cag ccc cgc tca agg ccc cgt caa agt ccg gcc aag tct        624
Cys Ser Cys Gln Pro Arg Ser Arg Pro Arg Gln Ser Pro Ala Lys Ser           
        195                 200                 205                       

tcc cag gat cac gcg atg gaa gcc ggc agc cct gtg agc aca tcc ccc        672
Ser Gln Asp His Ala Met Glu Ala Gly Ser Pro Val Ser Thr Ser Pro           
    210                 215                 220                           

gag cca gtg gag acc tgc agc ttc tgc ttc cct gag tgc agg gcg ccc        720
Glu Pro Val Glu Thr Cys Ser Phe Cys Phe Pro Glu Cys Arg Ala Pro           
225                 230                 235                 240           

acg cag gag agc gca gtc acg cct ggg acc ccc gac ccc act tgt gct        768
Thr Gln Glu Ser Ala Val Thr Pro Gly Thr Pro Asp Pro Thr Cys Ala           
                245                 250                 255               

gga agg tgg ggg tgc cac acc agg acc aca gtc ctg cag cct tgc cca        816
Gly Arg Trp Gly Cys His Thr Arg Thr Thr Val Leu Gln Pro Cys Pro           
            260                 265                 270                   

cac atc cca gac agt ggc ctt ggc att gtg tgt gtg cct gcc cag gag        864
His Ile Pro Asp Ser Gly Leu Gly Ile Val Cys Val Pro Ala Gln Glu           
        275                 280                 285                       

ggg ggc cca ggt gca taa                                                882
Gly Gly Pro Gly Ala                                                       
    290                                                                   


<210>  63
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 
1               5                   10                  15      


Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg 
            20                  25                  30          


Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met 
        35                  40                  45              


Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 
    50                  55                  60                  


Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp 
65                  70                  75                  80  


His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His 
                85                  90                  95      


Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val 
            100                 105                 110         


Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn 
        115                 120                 125             


Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser 
    130                 135                 140                 


Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val 
145                 150                 155                 160 


Ala Leu Val Tyr Ser Thr Leu Gly Leu Cys Leu Cys Ala Val Leu Cys 
                165                 170                 175     


Cys Phe Leu Val Ala Val Ala Cys Phe Leu Lys Lys Arg Gly Asp Pro 
            180                 185                 190         


Cys Ser Cys Gln Pro Arg Ser Arg Pro Arg Gln Ser Pro Ala Lys Ser 
        195                 200                 205             


Ser Gln Asp His Ala Met Glu Ala Gly Ser Pro Val Ser Thr Ser Pro 
    210                 215                 220                 


Glu Pro Val Glu Thr Cys Ser Phe Cys Phe Pro Glu Cys Arg Ala Pro 
225                 230                 235                 240 


Thr Gln Glu Ser Ala Val Thr Pro Gly Thr Pro Asp Pro Thr Cys Ala 
                245                 250                 255     


Gly Arg Trp Gly Cys His Thr Arg Thr Thr Val Leu Gln Pro Cys Pro 
            260                 265                 270         


His Ile Pro Asp Ser Gly Leu Gly Ile Val Cys Val Pro Ala Gln Glu 
        275                 280                 285             


Gly Gly Pro Gly Ala 
    290             


<210>  64
<211>  834
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (67)..(621)

<400>  64
ttgtaagata ttacttgtcc ttccaggctg ttctttctgt agctcccttg ttttcttttt       60

gtgatc atg ttg cag atg gct ggg cag tgc tcc caa aat gaa tat ttt         108
       Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe            
       1               5                   10                             

gac agt ttg ttg cat gct tgc ata cct tgt caa ctt cga tgt tct tct        156
Asp Ser Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser           
15                  20                  25                  30            

aat act cct cct cta aca tgt cag cgt tat tgt aat gca agt gtg acc        204
Asn Thr Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr           
                35                  40                  45                

aat tca gtg aaa gga acg aat gcg att ctc tgg acc tgt ttg gga ctg        252
Asn Ser Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu           
            50                  55                  60                    

agc tta ata att tct ttg gca gtt ttc gtg cta atg ttt ttg cta agg        300
Ser Leu Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg           
        65                  70                  75                        

aag ata agc tct gaa cca tta aag gac gag ttt aaa aac aca gga tca        348
Lys Ile Ser Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser           
    80                  85                  90                            

ggt ctc ctg ggc atg gct aac att gac ctg gaa aag agc agg act ggt        396
Gly Leu Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly           
95                  100                 105                 110           

gat gaa att att ctt ccg aga ggc ctc gag tac acg gtg gaa gaa tgc        444
Asp Glu Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys           
                115                 120                 125               

acc tgt gaa gac tgc atc aag agc aaa ccg aag gtc gac tct gac cat        492
Thr Cys Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His           
            130                 135                 140                   

tgc ttt cca ctc cca gct atg gag gaa ggc gca acc att ctt gtc acc        540
Cys Phe Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr           
        145                 150                 155                       

acg aaa acg aat gac tat tgc aag agc ctg cca gct gct ttg agt gct        588
Thr Lys Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala           
    160                 165                 170                           

acg gag ata gag aaa tca att tct gct agg taa ttaaccattt cgactcgagc      641
Thr Glu Ile Glu Lys Ser Ile Ser Ala Arg                                   
175                 180                                                   

agtgccactt taaaaatctt ttgtcagaat agatgatgtg tcagatctct ttaggatgac      701

tgtatttttc agttgccgat acagcttttt gtcctctaac tgtggaaact ctttatgtta      761

gatatatttc tctaggttac tgttgggagc ttaatggtag aaacttcctt ggtttctatg      821

attaaagtct ttt                                                         834


<210>  65
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Ser Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                85                  90                  95      


Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
            100                 105                 110         


Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
        115                 120                 125             


Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
    130                 135                 140                 


Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
145                 150                 155                 160 


Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                165                 170                 175     


Ile Glu Lys Ser Ile Ser Ala Arg 
            180                 


<210>  66
<211>  899
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (6)..(560)

<400>  66
gcacc atg agg cga ggg ccc cgg agc ctg cgg ggc agg gac gcg cca gcc       50
      Met Arg Arg Gly Pro Arg Ser Leu Arg Gly Arg Asp Ala Pro Ala         
      1               5                   10                  15          

ccc acg ccc tgc gtc ccg gcc gag tgc ttc gac ctg ctg gtc cgc cac         98
Pro Thr Pro Cys Val Pro Ala Glu Cys Phe Asp Leu Leu Val Arg His           
                20                  25                  30                

tgc gtg gcc tgc ggg ctc ctg cgc acg ccg cgg ccg aaa ccg gcc ggg        146
Cys Val Ala Cys Gly Leu Leu Arg Thr Pro Arg Pro Lys Pro Ala Gly           
            35                  40                  45                    

gcc agc agc cct gcg ccc agg acg gcg ctg cag ccg cag gag tcg gtg        194
Ala Ser Ser Pro Ala Pro Arg Thr Ala Leu Gln Pro Gln Glu Ser Val           
        50                  55                  60                        

ggc gcg ggg gcc ggc gag gcg gcg ctg ccc ctg ccc ggg ctg ctc ttt        242
Gly Ala Gly Ala Gly Glu Ala Ala Leu Pro Leu Pro Gly Leu Leu Phe           
    65                  70                  75                            

ggc gcc ccc gcg ctg ctg ggc ctg gca ctg gtc ctg gcg ctg gtc ctg        290
Gly Ala Pro Ala Leu Leu Gly Leu Ala Leu Val Leu Ala Leu Val Leu           
80                  85                  90                  95            

gtg ggt ctg gtg agc tgg agg cgg cga cag cgg cgg ctt cgc ggc gcg        338
Val Gly Leu Val Ser Trp Arg Arg Arg Gln Arg Arg Leu Arg Gly Ala           
                100                 105                 110               

tcc tcc gca gag gcc ccc gac gga gac aag gac gcc cca gag ccc ctg        386
Ser Ser Ala Glu Ala Pro Asp Gly Asp Lys Asp Ala Pro Glu Pro Leu           
            115                 120                 125                   

gac aag gtc atc att ctg tct ccg gga atc tct gat gcc aca gct cct        434
Asp Lys Val Ile Ile Leu Ser Pro Gly Ile Ser Asp Ala Thr Ala Pro           
        130                 135                 140                       

gcc tgg cct cct cct ggg gaa gac cca gga acc acc cca cct ggc cac        482
Ala Trp Pro Pro Pro Gly Glu Asp Pro Gly Thr Thr Pro Pro Gly His           
    145                 150                 155                           

agt gtc cct gtg cca gcc aca gag ctg ggc tcc act gaa ctg gtg acc        530
Ser Val Pro Val Pro Ala Thr Glu Leu Gly Ser Thr Glu Leu Val Thr           
160                 165                 170                 175           

acc aag acg gcc ggc cct gag caa caa tag cagggagccg gcaggaggtg          580
Thr Lys Thr Ala Gly Pro Glu Gln Gln                                       
                180                                                       

gcccctgccc tccctctgga cccccagcca ggggcttgga aatcaaattc agctcttcac      640

tccagcatgc acatgccctc tttctgggac caggctaacc ctgcagaagc acagacacta      700

cagaccacag cattcagccc ccatggagtt tggtgtgctt gcctttggct tcagacctca      760

ccatctttga cagcccttga aggtggtagc ccagctcctg ttcctgtgcc ttcaaaaggc      820

tggggcacta tgagtaaaag accgctttta aaatggggaa ggcaccatta agccaaaatg      880

aatctgaaaa aagacaaaa                                                   899


<210>  67
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Arg Arg Gly Pro Arg Ser Leu Arg Gly Arg Asp Ala Pro Ala Pro 
1               5                   10                  15      


Thr Pro Cys Val Pro Ala Glu Cys Phe Asp Leu Leu Val Arg His Cys 
            20                  25                  30          


Val Ala Cys Gly Leu Leu Arg Thr Pro Arg Pro Lys Pro Ala Gly Ala 
        35                  40                  45              


Ser Ser Pro Ala Pro Arg Thr Ala Leu Gln Pro Gln Glu Ser Val Gly 
    50                  55                  60                  


Ala Gly Ala Gly Glu Ala Ala Leu Pro Leu Pro Gly Leu Leu Phe Gly 
65                  70                  75                  80  


Ala Pro Ala Leu Leu Gly Leu Ala Leu Val Leu Ala Leu Val Leu Val 
                85                  90                  95      


Gly Leu Val Ser Trp Arg Arg Arg Gln Arg Arg Leu Arg Gly Ala Ser 
            100                 105                 110         


Ser Ala Glu Ala Pro Asp Gly Asp Lys Asp Ala Pro Glu Pro Leu Asp 
        115                 120                 125             


Lys Val Ile Ile Leu Ser Pro Gly Ile Ser Asp Ala Thr Ala Pro Ala 
    130                 135                 140                 


Trp Pro Pro Pro Gly Glu Asp Pro Gly Thr Thr Pro Pro Gly His Ser 
145                 150                 155                 160 


Val Pro Val Pro Ala Thr Glu Leu Gly Ser Thr Glu Leu Val Thr Thr 
                165                 170                 175     


Lys Thr Ala Gly Pro Glu Gln Gln 
            180                 


<210>  68
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Neutrokine-alpha inhibitory peptibody

<400>  68

Met Leu Pro Gly Cys Lys Trp Asp Leu Leu Ile Lys Gln Trp Val Cys 
1               5                   10                  15      


Asp Pro Leu Gly Ser Gly Ser Ala Thr Gly Gly Ser Gly Ser Thr Ala 
            20                  25                  30          


Ser Ser Gly Ser Gly Ser Ala Thr His Met Leu Pro Gly Cys Lys Trp 
        35                  40                  45              


Asp Leu Leu Ile Lys Gln Trp Val Cys Asp Pro Leu Gly Gly Gly Gly 
    50                  55                  60                  


Gly Val Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
65                  70                  75                  80  


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                85                  90                  95      


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            100                 105                 110         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        115                 120                 125             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    130                 135                 140                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
145                 150                 155                 160 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                165                 170                 175     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            180                 185                 190         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        195                 200                 205             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    210                 215                 220                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
225                 230                 235                 240 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                245                 250                 255     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            260                 265                 270         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        275                 280                 285             


Leu Ser Pro Gly Lys 
    290             


<210>  69
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Neutrokine-alpha inhibitory peptibody

<400>  69

Met Phe His Asp Cys Lys Trp Asp Leu Leu Thr Lys Gln Trp Val Cys 
1               5                   10                  15      


His Gly Leu Gly Ser Gly Ser Ala Thr Gly Gly Ser Gly Ser Thr Ala 
            20                  25                  30          


Ser Ser Gly Ser Gly Ser Ala Thr His Met Phe His Asp Cys Lys Trp 
        35                  40                  45              


Asp Leu Leu Thr Lys Gln Trp Val Cys His Gly Leu Gly Gly Gly Gly 
    50                  55                  60                  


Gly Val Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
65                  70                  75                  80  


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                85                  90                  95      


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            100                 105                 110         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        115                 120                 125             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    130                 135                 140                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
145                 150                 155                 160 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                165                 170                 175     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            180                 185                 190         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        195                 200                 205             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    210                 215                 220                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
225                 230                 235                 240 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                245                 250                 255     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            260                 265                 270         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        275                 280                 285             


Leu Ser Pro Gly Lys 
    290             


<210>  70
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Neutrokine-alpha binding peptide

<400>  70

Gly Gln Met Gly Trp Arg Trp Asp Pro Leu Thr Lys Met Trp Leu Gly 
1               5                   10                  15      


Thr Ser 
        


<210>  71
<211>  70
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acids 1-70 of BAFF-R with V20N & L27P substitutions

<400>  71

Met Arg Arg Gly Pro Arg Ser Leu Arg Gly Arg Asp Ala Pro Ala Pro 
1               5                   10                  15      


Thr Pro Cys Asn Pro Ala Glu Cys Phe Asp Pro Leu Val Arg His Cys 
            20                  25                  30          


Val Ala Cys Gly Leu Leu Arg Thr Pro Arg Pro Lys Pro Ala Gly Ala 
        35                  40                  45              


Ser Ser Pro Ala Pro Arg Thr Ala Leu Gln Pro Gln Glu Ser Val Gly 
    50                  55                  60                  


Ala Gly Ala Gly Glu Ala 
65                  70  


<210> 72
<211> 249
<212> PRT
<213> Homo sapiens

<400> 72

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
  1               5                  10                  15     


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
             20                  25                  30         


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
         35                  40                  45             


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
     50                  55                  60                 


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
 65                  70                  75                  80 


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                 85                  90                  95     


Arg Gly Pro Arg Tyr Tyr Asp Ile Leu Thr Gly Tyr Arg Tyr Asn Trp 
            100                 105                 110         


Phe Asp Pro Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Val Leu Ile Tyr Lys Ala 
            180                 185                 190         


Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Leu Glu Ile Lys Arg 
                245                 


<210> 73
<211> 251
<212> PRT
<213> Homo sapiens

<400> 73

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
  1               5                  10                  15     


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Phe Ile Ser Ser Arg 
             20                  25                  30         


Thr Ser Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro Glu 
         35                  40                  45             


Trp Ile Gly Asn Ile Tyr Tyr Thr Gly Lys Thr Tyr Tyr Ser Pro Ser 
     50                  55                  60                 


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu 
 65                  70                  75                  80 


Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                 85                  90                  95     


Cys Ala Arg Ala Gly Tyr Asp Leu Leu Thr Gly Tyr Pro Phe Tyr Phe 
            100                 105                 110         


Asp Ser Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Ile 
    130                 135                 140                 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145                 150                 155                 160 


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp 
            180                 185                 190         


Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
    210                 215                 220                 


Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Phe Leu Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
                245                 250     

