                         LISTA DE SECUENCIAS

<110>  Fundacin Centro Nacional de Investigaciones 
       Cardiovasculares Carlos III
 
<120>  USO DE COMPUESTOS ANTICALCINEURINA PARA EL TRATAMIENTO DE 
       PATOLOGAS QUE CURSAN CON NEOVASCULARIZACIN OCULAR

<130>  P5612PC00

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pptido correspondiente a una secuencia de la subunidad RII de la
       quinasa dependiente de AMP cclico

<400>  1

Asp Leu Val Pro Ile Pro Gly Arg Phe Asp Arg Val Ser Val Ala Ala 
1               5                   10                  15      


Glu 
    


<210>  2
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pptido basado en la secuencia del dominio autoinhibitorio de 
       calcineurina A

<400>  2

Ile Thr Ser Phe Glu Glu Ala Lys Gly Leu Asp Arg Ile Asn Glu Arg 
1               5                   10                  15      


Met Pro Pro Arg Arg Asp Ala Met Pro 
            20                  25  


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secuencia derivada de AKAP79

<400>  3

Arg Arg Lys Arg Ser Gln Ser Ser Lys Glu Glu Lys Pro 
1               5                   10              


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secuencia derivada de AKAP79

<400>  4

Arg Arg Lys Arg Ser Gln Ser Ser Lys Glu Glu Lys Pro Leu Gln 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secuencia derivada de AKAP79

<400>  5

Arg Arg Lys Arg Ser Gln Ser Ser Lys Glu Glu Lys Pro Phe Lys 
1               5                   10                  15  


<210>  6
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pptido autoinhibitorio calcineurina  residuos 457 a 482

<400>  6

Ile Thr Ser Phe Glu Glu Ala Lys Gly Leu Asp Arg Ile Asn Glu Arg 
1               5                   10                  15      


Met Pro Pro Arg Arg Asp Ala Met Pro 
            20                  25  


<210>  7
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pptido autoinhibitorio de calcineurina residuos 424 a 521

<400>  7

Lys Gly Leu Thr Pro Thr Gly Met Leu Pro Ser Gly Val Leu Ser Gly 
1               5                   10                  15      


Gly Lys Gln Thr Leu Gln Ser Ala Thr Val Glu Ala Ile Glu Ala Asp 
            20                  25                  30          


Glu Ala Ile Lys Gly Phe Ser Pro Gln His Lys Ile Thr Ser Phe Glu 
        35                  40                  45              


Glu Ala Lys Gly Leu Asp Arg Ile Asn Glu Arg Met Pro Pro Arg Arg 
    50                  55                  60                  


Asp Ala Met Pro Ser Asp Ala Asn Leu Asn Ser Ile Asn Lys Ala Leu 
65                  70                  75                  80  


Thr Ser Glu Thr Asn Gly Thr Asp Ser Asn Gly Ser Asn Ser Ser Asn 
                85                  90                  95      


Ile Gln 
        


<210>  8
<211>  2182
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Met Ile Arg Ile Ala Ala Leu Asn Ala Ser Ser Thr Ile Glu Asp Asp 
1               5                   10                  15      


His Glu Gly Ser Phe Lys Ser His Lys Ile Gln Thr Lys Glu Ala Gln 
            20                  25                  30          


Glu Ala Glu Ala Phe Ala Leu Tyr His Lys Ala Leu Asp Leu Gln Lys 
        35                  40                  45              


His Asp Arg Phe Glu Glu Ser Ala Lys Ala Tyr His Glu Leu Leu Glu 
    50                  55                  60                  


Ala Arg Leu Leu Arg Glu Ala Val Ser Ser Gly Asp Glu Lys Glu Gly 
65                  70                  75                  80  


Leu Lys His Pro Gly Leu Ile Leu Lys Tyr Ser Thr Tyr Lys Asn Leu 
                85                  90                  95      


Ala Gln Leu Ala Ala Gln Arg Glu Asp Leu Glu Thr Ala Met Glu Phe 
            100                 105                 110         


Tyr Leu Glu Ala Val Met Leu Asp Ser Thr Asp Val Asn Leu Trp Tyr 
        115                 120                 125             


Lys Ile Gly His Val Ala Leu Arg Leu Ile Arg Leu Pro Leu Ala Arg 
    130                 135                 140                 


His Ala Phe Glu Glu Gly Leu Arg Cys Asn Pro Asp His Trp Pro Cys 
145                 150                 155                 160 


Leu Asp Asn Leu Ile Thr Val Leu Tyr Thr Leu Ser Asp Tyr Thr Thr 
                165                 170                 175     


Cys Leu Tyr Phe Ile Cys Lys Ala Leu Glu Lys Asp Cys Arg Tyr Ser 
            180                 185                 190         


Lys Gly Leu Val Leu Lys Glu Lys Ile Phe Glu Glu Gln Pro Cys Leu 
        195                 200                 205             


Arg Lys Asp Ser Leu Arg Met Phe Leu Lys Cys Asp Met Ser Val His 
    210                 215                 220                 


Glu Val Ser Val Asn Ala Ala Glu Thr Gln Ala Ile Val Asp Glu Ala 
225                 230                 235                 240 


Leu Gly Leu Arg Lys Lys Arg Gln Ala Leu Ile Val Arg Glu Lys Glu 
                245                 250                 255     


Pro Asp Leu Lys Leu Val Gln Pro Ile Pro Phe Phe Thr Trp Lys Cys 
            260                 265                 270         


Leu Gly Glu Ser Leu Leu Ala Met Tyr Asn His Leu Thr Thr Cys Glu 
        275                 280                 285             


Pro Pro Arg Pro Ser Leu Gly Lys Arg Ile Asp Leu Ser Asp Tyr Gln 
    290                 295                 300                 


Asp Pro Ser Gln Leu Leu Ala Pro Ser Ile Val Val Thr Pro Val Ser 
305                 310                 315                 320 


Val Val Gln Pro Ser Pro Val Cys Thr Asn Pro Thr Val Ala Val Ala 
                325                 330                 335     


Glu Pro Val Leu Ser Tyr Thr Ser Val Thr Thr Thr Ser Phe Pro Leu 
            340                 345                 350         


His Ser Pro Gly Leu Leu Asp Thr Gly Thr Pro Met Gly Asp Val Ser 
        355                 360                 365             


Gly Gly Asp Lys Ser Lys Lys Gly Val Lys Arg Lys Lys Thr Leu Glu 
    370                 375                 380                 


Glu Ser Gly Glu Thr Ala Lys Arg Arg Ser Ala Arg Val Arg Asn Thr 
385                 390                 395                 400 


Lys Cys Lys Lys Glu Glu Lys Val Asp Phe Gln Gly Leu Leu Val Lys 
                405                 410                 415     


Phe Leu Pro Ser Arg Leu Arg Lys Leu Asp Pro Glu Glu Glu Asp Asp 
            420                 425                 430         


Pro Phe Asn Asn Tyr Glu Val Gln Ser Glu Ala Lys Leu Glu Ser Phe 
        435                 440                 445             


Ser Asn Val Gly Pro His Arg Leu Ser Phe Asp Ser Ala Thr Phe Met 
    450                 455                 460                 


Glu Ser Glu Lys Gln Asp Val His Ala Phe Leu Met Glu Asn Leu Thr 
465                 470                 475                 480 


Asn Gly Gly Val Leu Glu Leu Met Met Arg Tyr Leu Lys Ser Met Gly 
                485                 490                 495     


His Lys Phe Leu Leu Lys Trp Pro Pro Gly Leu Ala Glu Val Val Leu 
            500                 505                 510         


Ser Val Tyr His Ser Trp Arg Arg His Ser Thr Ser Leu Pro Asn Pro 
        515                 520                 525             


Leu Leu Arg Asp Cys Ser Asn Lys His Ile Lys Asp Met Met Leu Met 
    530                 535                 540                 


Ser Leu Ser Cys Met Glu Leu Gln Leu Asp Gln Trp Leu Leu Thr Lys 
545                 550                 555                 560 


Gly Arg Ser Ser Thr Val Ser Pro Arg Asn Cys Pro Ala Gly Val Val 
                565                 570                 575     


Thr Gly Arg Phe Gly Pro Asp Phe Pro Gly Thr His Cys Leu Gly Asp 
            580                 585                 590         


Leu Leu Gln Leu Ser Phe Ala Ser Ser Gln Arg Asp Leu Phe Glu Asp 
        595                 600                 605             


Gly Trp Leu Glu Phe Val Val Arg Val Tyr Trp Leu Lys Ala Arg Phe 
    610                 615                 620                 


Leu Ala Leu Gln Gly Asp Met Glu Gln Ala Leu Glu Asn Tyr Asp Ile 
625                 630                 635                 640 


Cys Thr Glu Ile Leu Gln Ser Ser Thr Ala Leu Gln Ala Gln Ala Gly 
                645                 650                 655     


Ala Glu Gln Arg Asp Ile Val Ile Arg Leu Pro Asn Leu His Asn Asp 
            660                 665                 670         


Ser Ile Val Ser Leu Glu Glu Ile Asp Lys Asn Leu Lys Ser Leu Glu 
        675                 680                 685             


Arg Cys Gln Ser Leu Glu Glu Ile Gln Arg Leu Phe Glu Ala Gly Asp 
    690                 695                 700                 


Tyr Lys Ala Val Val Gln Leu Leu Arg Pro Thr Leu Cys Thr Ser Gly 
705                 710                 715                 720 


Phe Asp Arg Ala Lys His Leu Glu Phe Met Thr Ser Ile Pro Glu Arg 
                725                 730                 735     



Pro Ala Gln Leu Leu Leu Leu Gln Asp Ser Leu Leu Arg Leu Glu Glu 
            740                 745                 750         


His Arg Gln Cys Phe Glu Cys Ser Asp Val Ala Leu Asn Glu Ala Val 
        755                 760                 765             


Gln Gln Met Leu Asn Ser Ser Asp Ser Ala Ala Lys Glu Glu Trp Ala 
    770                 775                 780                 


Ala Thr Val Thr Gln Leu Leu Leu Gly Met Glu Gln Ala Leu Ser Ser 
785                 790                 795                 800 


Asp Ser Arg Gly Ser Ile Leu Lys Glu Ser Ser Ser Pro Thr Gly Leu 
                805                 810                 815     


Val Arg Leu Thr Asn Asn Leu Ile Gln Val Ile Asp Cys Ser Met Ala 
            820                 825                 830         


Val Gln Glu Glu Pro Lys Glu Pro Tyr Val Ser Ser Val Leu Pro Trp 
        835                 840                 845             


Ile Ile Leu His Arg Ile Ile Trp Gln Glu Glu Asp Thr Phe Arg Ser 
    850                 855                 860                 


Leu Cys His Gln Gln Gln Leu Gln Asn Pro Thr Glu Glu Gly Ile Ser 
865                 870                 875                 880 


Glu Met Pro Met Leu Pro Ser Ser Leu Met Leu Leu Asn Thr Ala His 
                885                 890                 895     


Glu Tyr Leu Gly Arg Arg Ser Trp Cys Cys Asn Ser Asp Gly Ala Leu 
            900                 905                 910         


Leu Arg Phe Tyr Val His Val Leu Gln Lys Glu Leu Ala Ala Ser Ala 
        915                 920                 925             


Ser Glu Asp Thr His Pro Tyr Lys Glu Glu Leu Glu Thr Ala Leu Glu 
    930                 935                 940                 


Gln Cys Phe Tyr Cys Leu Tyr Ser Phe Pro Ser Lys Lys Ser Lys Ala 
945                 950                 955                 960 



Arg Tyr Leu Glu Glu His Ser Ala Gln Gln Val Asp Leu Thr Trp Glu 
                965                 970                 975     


Asp Ala Leu Phe Met Phe Glu Tyr Phe Lys Pro Lys Thr Leu Pro Glu 
            980                 985                 990         


Phe Asp Ser Tyr Lys Thr Ser Thr  Val Ser Ala Asp Leu  Ala Asn Leu 
        995                 1000                 1005             


Leu Lys  Arg Ile Ala Thr Ile  Val Pro Arg Thr Glu  Lys Pro Ala 
    1010                 1015                 1020             


Leu Ser  Met Asp Lys Val Ser  Ala Tyr Ile Glu Gly  Thr Ser Ala 
    1025                 1030                 1035             


Glu Val  Pro Cys Leu Pro Asp  Gly Ala Asp Pro Ala  Pro Pro Val 
    1040                 1045                 1050             


Leu Asn  Glu Leu Tyr Tyr Leu  Leu Ala Asp Tyr His  Phe Lys Asn 
    1055                 1060                 1065             


Lys Glu  Gln Ser Lys Ala Ile  Lys Phe Tyr Met His  Asp Ile Cys 
    1070                 1075                 1080             


Ile Cys  Pro Asn Arg Phe Asp  Ser Trp Ala Gly Met  Ala Leu Ala 
    1085                 1090                 1095             


Arg Ala  Ser Arg Ile Gln Asp  Lys Leu Asn Ser Asn  Glu Leu Lys 
    1100                 1105                 1110             


Ser Asp  Gly Pro Ile Trp Arg  His Ala Thr Pro Val  Leu Asn Cys 
    1115                 1120                 1125             


Phe Arg  Arg Ala Leu Glu Ile  Asp Ser Ser Asn Leu  Ser Leu Trp 
    1130                 1135                 1140             


Ile Glu  Tyr Gly Thr Met Ser  Tyr Ala Leu His Ser  Phe Ala Ser 
    1145                 1150                 1155             


Arg Gln  Leu Lys Gln Trp Arg  Ala Glu Leu Pro Pro  Glu Val Val 
    1160                 1165                 1170             



Gln Gln  Met Glu Asp Arg Arg  Asp Ser Met Leu Glu  Thr Ala Arg 
    1175                 1180                 1185             


His Cys  Phe Thr Ser Ala Ala  His Cys Glu Gly Asp  Gly Asp Glu 
    1190                 1195                 1200             


Glu Glu  Trp Leu Ile His Tyr  Met Leu Gly Lys Val  Ala Glu Lys 
    1205                 1210                 1215             


Gln Gln  Gln Pro Pro Thr Val  Tyr Leu Leu His Tyr  Arg Gln Ala 
    1220                 1225                 1230             


Gly His  Tyr Leu His Glu Glu  Ala Ala Arg Tyr Pro  Lys Lys Ile 
    1235                 1240                 1245             


His Tyr  His Asn Pro Pro Glu  Leu Ala Met Glu Ala  Leu Glu Val 
    1250                 1255                 1260             


Tyr Phe  Arg Leu His Ala Ser  Ile Leu Lys Leu Leu  Gly Lys Pro 
    1265                 1270                 1275             


Asp Ser  Gly Val Ser Ala Glu  Val Leu Val Ser Phe  Met Lys Glu 
    1280                 1285                 1290             


Ala Ala  Glu Gly Pro Phe Ala  Arg Gly Glu Glu Lys  Asn Thr Pro 
    1295                 1300                 1305             


Lys Ala  Ser Glu Lys Glu Lys  Ala Cys Leu Val Asp  Glu Asp Ser 
    1310                 1315                 1320             


His Ser  Ser Ala Gly Thr Leu  Pro Gly Pro Gly Ala  Ser Leu Pro 
    1325                 1330                 1335             


Ser Ser  Ser Gly Pro Gly Leu  Thr Ser Pro Pro Tyr  Thr Ala Thr 
    1340                 1345                 1350             


Pro Ile  Asp His Asp Tyr Val  Lys Cys Lys Lys Pro  Arg Gln Gln 
    1355                 1360                 1365             


Ala Thr  Pro Asp Asp Arg Ser  Gln Asp Ser Thr Ala  Val Ala Leu 
    1370                 1375                 1380             



Ser Asp  Ser Ser Ser Thr Gln  Asp Phe Phe Asn Glu  Pro Thr Ser 
    1385                 1390                 1395             


Leu Leu  Asp Gly Ser Arg Lys  Leu Leu Pro Glu Lys  Arg Ile Ser 
    1400                 1405                 1410             


Gly Leu  Ser Ala Gln Ala Gly  Pro Ser Gly Lys Asp  Leu Pro Gly 
    1415                 1420                 1425             


Pro Thr  Glu Glu Arg Gly Lys  Thr Glu Glu Ser Leu  Glu Ser Thr 
    1430                 1435                 1440             


Glu Ala  Phe Arg Val Val Glu  Pro Ser Val Gln Lys  Pro Val Ala 
    1445                 1450                 1455             


Asp Ser  Ser Ala Ser Ala Tyr  Ile Pro Ser Lys Pro  Ala Val Ser 
    1460                 1465                 1470             


Thr Pro  Pro Pro Trp Asp Gly  Lys Lys Arg Ser Asp  Pro Leu Gly 
    1475                 1480                 1485             


Glu Pro  Val Ala Phe Pro Gln  Gly Leu Pro Ala Gly  Ala Glu Glu 
    1490                 1495                 1500             


Gln Arg  Gln Phe Leu Thr Glu  Gln Cys Ile Ala Ser  Phe Cys Leu 
    1505                 1510                 1515             


Cys Leu  Ser Arg Phe Pro Gln  His Tyr Lys Ser Leu  Tyr Arg Leu 
    1520                 1525                 1530             


Ala Phe  Leu Tyr Thr Tyr Ser  Lys Thr His Arg Asn  Leu Gln Trp 
    1535                 1540                 1545             


Ala Arg  Asp Val Leu Leu Gly  Ser Ser Ile Pro Trp  Gln Gln Leu 
    1550                 1555                 1560             


Gln His  Met Pro Ala Gln Gly  Leu Phe Cys Glu Arg  Asn Lys Thr 
    1565                 1570                 1575             


Asn Phe  Phe Asn Gly Ile Trp  Arg Ile Pro Val Asp  Glu Ile Asp 
    1580                 1585                 1590             



Arg Pro  Gly Ser Phe Ala Trp  His Met Asn Arg Ser  Ile Val Leu 
    1595                 1600                 1605             


Leu Leu  Lys Val Leu Ala Gln  Leu Arg Asp His Ser  Thr Leu Leu 
    1610                 1615                 1620             


Lys Val  Ser Ser Met Leu Gln  Arg Thr Pro Asp Gln  Gly Lys Lys 
    1625                 1630                 1635             


Tyr Leu  Arg Asp Ala Asp Arg  Gln Val Leu Ala Gln  Arg Ala Phe 
    1640                 1645                 1650             


Ile Leu  Thr Val Lys Val Leu  Glu Asp Thr Leu Ser  Glu Leu Ala 
    1655                 1660                 1665             


Glu Gly  Leu Glu His Pro Gly  Ser Lys Ala Cys Gly  Leu Ser Gly 
    1670                 1675                 1680             


Ala Arg  Met Thr Thr Asp Val  Ser His Lys Ala Ser  Pro Glu Asp 
    1685                 1690                 1695             


Gly Gln  Glu Ser Leu Pro His  Pro Lys Lys Leu Pro  Leu Ala Asp 
    1700                 1705                 1710             


Gly Ser  Gly Pro Gly Pro Glu  Pro Gly Gly Lys Val  Gly Pro Leu 
    1715                 1720                 1725             


His Gln  Leu Pro Val Ala Thr  Asp Thr Arg Asp Asn  Thr Glu Gln 
    1730                 1735                 1740             


Gly Gly  Glu Pro Lys Asp Lys  Glu Arg Pro Pro Val  Gly Pro Thr 
    1745                 1750                 1755             


Glu Pro  Met Asp Thr Gly Glu  Thr Ala Ala Arg His  Pro Asp Leu 
    1760                 1765                 1770             


Glu Pro  Thr Pro Arg Leu Leu  Pro Gly Arg Pro Pro  Arg Asp Arg 
    1775                 1780                 1785             


Gly Pro  Glu Ser Arg Ser Ala  Glu Leu Ser Leu Glu  Glu Leu Ser 
    1790                 1795                 1800             



Ile Ser  Thr Arg Gln Gln Pro  Ala Pro Leu Val Pro  Ser Pro Val 
    1805                 1810                 1815             


Thr Pro  Thr Thr Ala Ala Pro  Thr Thr Met Gly Ala  Arg Ala Ala 
    1820                 1825                 1830             


Gly His  Pro Glu Glu Ala Pro  Pro Arg Pro Asn Arg  Lys Arg Lys 
    1835                 1840                 1845             


Leu Leu  Gln Asp Thr Glu Ser  Gly Lys Thr Leu Leu  Leu Asp Ala 
    1850                 1855                 1860             


Tyr Arg  Val Trp Gln Gln Gly  Gln Lys Ala Met Ala  Tyr Asp Leu 
    1865                 1870                 1875             


Ser Arg  Ile Glu Lys Ile Met  Ser Glu Thr Tyr Met  Leu Ile Lys 
    1880                 1885                 1890             


Gln Val  Asp Glu Glu Thr Ala  Leu Glu Gln Ala Val  Lys Phe Cys 
    1895                 1900                 1905             


Gln Val  His Leu Gly Ala Ala  Ala Gln Arg Gln Ala  Ser Gly Asp 
    1910                 1915                 1920             


Ala Pro  Thr Thr Pro Lys His  Pro Lys Asp Ser Arg  Glu Asn Phe 
    1925                 1930                 1935             


Phe Pro  Ala Thr Val Ala Pro  Ser Ala Pro Asp Thr  Thr Ala Pro 
    1940                 1945                 1950             


Asp Ala  Leu Gln Arg Pro Ser  Asp Ser His Leu Lys  Pro Gly Leu 
    1955                 1960                 1965             


Ala Ala  Ala Ile Thr Cys Pro  Pro Ser Ala Ser Ala  Ser Thr Pro 
    1970                 1975                 1980             


Asp Pro  Gly Ile Pro Gln Pro  His Arg Pro Glu Ala  Val Pro Ser 
    1985                 1990                 1995             


Arg Ala  Pro Leu Ser Pro Asp  Gly Glu Glu Val Ser  Gly Val Thr 
    2000                 2005                 2010             



Glu Gly  Pro Ser Phe Leu Ser  Gln Glu Pro Arg His  Ser His Gln 
    2015                 2020                 2025             


Met Lys  Met Ala Ala Thr Gly  Pro Leu Ala Glu Gln  His Cys Trp 
    2030                 2035                 2040             


Pro Val  Glu Ala Ala Cys Gln  Thr Gly Ala Glu Pro  Thr Phe Ser 
    2045                 2050                 2055             


Gln Ala  Thr Ser Thr Lys Val  Pro Ser Ser Gly Ser  Thr Gln Thr 
    2060                 2065                 2070             


Pro Glu  Ser His Gln Gly Lys  Thr Glu Ser Ser Arg  Ala Lys Ser 
    2075                 2080                 2085             


Arg Leu  Leu Pro Asn Met Pro  Lys Leu Val Ile Pro  Ser Ala Thr 
    2090                 2095                 2100             


Thr Lys  Phe Pro Pro Glu Ile  Thr Val Thr Pro Pro  Thr Pro Thr 
    2105                 2110                 2115             


Leu Leu  Ser Pro Lys Gly Ser  Ile Ser Glu Glu Thr  Lys Gln Lys 
    2120                 2125                 2130             


Leu Lys  Ser Ala Ile Leu Ser  Ala Gln Ser Ala Ala  Asn Val Arg 
    2135                 2140                 2145             


Lys Glu  Ser Leu Cys Gln Pro  Ala Leu Glu Val Leu  Glu Thr Ser 
    2150                 2155                 2160             


Ser Gln  Glu Ser Ser Leu Glu  Ser Glu Thr Asp Glu  Asp Asp Asp 
    2165                 2170                 2175             


Phe Met  Asp Val 
    2180         


<210>  9
<211>  2220
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ile Arg Ile Ala Ala Leu Asn Ala Ser Ser Thr Ile Glu Asp Asp 
1               5                   10                  15      


His Glu Gly Ser Phe Lys Ser His Lys Thr Gln Thr Lys Glu Ala Gln 
            20                  25                  30          


Glu Ala Glu Ala Phe Ala Leu Tyr His Lys Ala Leu Asp Leu Gln Lys 
        35                  40                  45              


His Asp Arg Phe Glu Glu Ser Ala Lys Ala Tyr His Glu Leu Leu Glu 
    50                  55                  60                  


Ala Ser Leu Leu Arg Glu Ala Val Ser Ser Gly Asp Glu Lys Glu Gly 
65                  70                  75                  80  


Leu Lys His Pro Gly Leu Ile Leu Lys Tyr Ser Thr Tyr Lys Asn Leu 
                85                  90                  95      


Ala Gln Leu Ala Ala Gln Arg Glu Asp Leu Glu Thr Ala Met Glu Phe 
            100                 105                 110         


Tyr Leu Glu Ala Val Met Leu Asp Ser Thr Asp Val Asn Leu Trp Tyr 
        115                 120                 125             


Lys Ile Gly His Val Ala Leu Arg Leu Ile Arg Ile Pro Leu Ala Arg 
    130                 135                 140                 


His Ala Phe Glu Glu Gly Leu Arg Cys Asn Pro Asp His Trp Pro Cys 
145                 150                 155                 160 


Leu Asp Asn Leu Ile Thr Val Leu Tyr Thr Leu Ser Asp Tyr Thr Thr 
                165                 170                 175     


Cys Leu Tyr Phe Ile Cys Lys Ala Leu Glu Lys Asp Cys Arg Tyr Ser 
            180                 185                 190         


Lys Gly Leu Val Leu Lys Glu Lys Ile Phe Glu Glu Gln Pro Cys Leu 
        195                 200                 205             


Arg Lys Asp Ser Leu Arg Met Phe Leu Lys Cys Asp Met Ser Ile His 
    210                 215                 220                 


Asp Val Ser Val Ser Ala Ala Glu Thr Gln Ala Ile Val Asp Glu Ala 
225                 230                 235                 240 


Leu Gly Leu Arg Lys Lys Arg Gln Ala Leu Ile Val Arg Glu Lys Glu 
                245                 250                 255     


Pro Asp Leu Lys Leu Val Gln Pro Ile Pro Phe Phe Thr Trp Lys Cys 
            260                 265                 270         


Leu Gly Glu Ser Leu Leu Ala Met Tyr Asn His Leu Thr Thr Cys Glu 
        275                 280                 285             


Pro Pro Arg Pro Ser Leu Gly Lys Arg Ile Asp Leu Ser Asp Tyr Gln 
    290                 295                 300                 


Asp Pro Ser Gln Pro Leu Glu Ser Ser Met Val Val Thr Pro Val Asn 
305                 310                 315                 320 


Val Ile Gln Pro Ser Thr Val Ser Thr Asn Pro Ala Val Ala Val Ala 
                325                 330                 335     


Glu Pro Val Val Ser Tyr Thr Ser Val Ala Thr Thr Ser Phe Pro Leu 
            340                 345                 350         


His Ser Pro Gly Leu Leu Glu Thr Gly Ala Pro Val Gly Asp Ile Ser 
        355                 360                 365             


Gly Gly Asp Lys Ser Lys Lys Gly Val Lys Arg Lys Lys Ile Ser Glu 
    370                 375                 380                 


Glu Ser Gly Glu Thr Ala Lys Arg Arg Ser Ala Arg Val Arg Asn Thr 
385                 390                 395                 400 


Lys Cys Lys Lys Glu Glu Lys Val Asp Phe Gln Glu Leu Leu Met Lys 
                405                 410                 415     


Phe Leu Pro Ser Arg Leu Arg Lys Leu Asp Pro Glu Glu Glu Asp Asp 
            420                 425                 430         


Ser Phe Asn Asn Tyr Glu Val Gln Ser Glu Ala Lys Leu Glu Ser Phe 
        435                 440                 445             


Pro Ser Ile Gly Pro Gln Arg Leu Ser Phe Asp Ser Ala Thr Phe Met 
    450                 455                 460                 


Glu Ser Glu Lys Gln Asp Val His Glu Phe Leu Leu Glu Asn Leu Thr 
465                 470                 475                 480 


Asn Gly Gly Ile Leu Glu Leu Met Met Arg Tyr Leu Lys Ala Met Gly 
                485                 490                 495     


His Lys Phe Leu Val Arg Trp Pro Pro Gly Leu Ala Glu Val Val Leu 
            500                 505                 510         


Ser Val Tyr His Ser Trp Arg Arg His Ser Thr Ser Leu Pro Asn Pro 
        515                 520                 525             


Leu Leu Arg Asp Cys Ser Asn Lys His Ile Lys Asp Met Met Leu Met 
    530                 535                 540                 


Ser Leu Ser Cys Met Glu Leu Gln Leu Asp Gln Trp Leu Leu Thr Lys 
545                 550                 555                 560 


Gly Arg Ser Ser Ala Val Ser Pro Arg Asn Cys Pro Ala Gly Met Val 
                565                 570                 575     


Asn Gly Arg Phe Gly Pro Asp Phe Pro Gly Thr His Cys Leu Gly Asp 
            580                 585                 590         


Leu Leu Gln Leu Ser Phe Ala Ser Ser Gln Arg Asp Leu Phe Glu Asp 
        595                 600                 605             


Gly Trp Leu Glu Phe Val Val Arg Val Tyr Trp Leu Lys Ala Arg Phe 
    610                 615                 620                 


Leu Ala Leu Gln Gly Asp Met Glu Gln Ala Leu Glu Asn Tyr Asp Ile 
625                 630                 635                 640 


Cys Thr Glu Met Leu Gln Ser Ser Thr Ala Ile Gln Val Glu Ala Gly 
                645                 650                 655     


Ala Glu Arg Arg Asp Ile Val Ile Arg Leu Pro Asn Leu His Asn Asp 
            660                 665                 670         


Ser Val Val Ser Leu Glu Glu Ile Asp Lys Asn Leu Lys Ser Leu Glu 
        675                 680                 685             



Arg Cys Gln Ser Leu Glu Glu Ile Gln Arg Leu Tyr Glu Ala Gly Asp 
    690                 695                 700                 


Tyr Lys Ala Val Val His Leu Leu Arg Pro Thr Leu Cys Thr Ser Gly 
705                 710                 715                 720 


Phe Asp Arg Ala Lys His Leu Glu Phe Met Thr Ser Ile Pro Glu Arg 
                725                 730                 735     


Pro Ala Gln Leu Leu Leu Leu Gln Asp Ser Leu Leu Arg Leu Lys Asp 
            740                 745                 750         


Tyr Arg Gln Cys Phe Glu Cys Ser Asp Val Ala Leu Asn Glu Ala Val 
        755                 760                 765             


Gln Gln Met Val Asn Ser Gly Glu Ala Ala Ala Lys Glu Glu Trp Val 
    770                 775                 780                 


Ala Thr Val Thr Gln Leu Leu Met Gly Ile Glu Gln Ala Leu Ser Ala 
785                 790                 795                 800 


Asp Ser Ser Gly Ser Ile Leu Lys Val Ser Ser Ser Thr Thr Gly Leu 
                805                 810                 815     


Val Arg Leu Thr Asn Asn Leu Ile Gln Val Ile Asp Cys Ser Met Ala 
            820                 825                 830         


Val Gln Glu Glu Ala Lys Glu Pro His Val Ser Ser Val Leu Pro Trp 
        835                 840                 845             


Ile Ile Leu His Arg Ile Ile Trp Gln Glu Glu Asp Thr Phe His Ser 
    850                 855                 860                 


Leu Cys His Gln Gln Gln Leu Gln Asn Pro Ala Glu Glu Gly Met Ser 
865                 870                 875                 880 


Glu Thr Pro Met Leu Pro Ser Ser Leu Met Leu Leu Asn Thr Ala His 
                885                 890                 895     


Glu Tyr Leu Gly Arg Arg Ser Trp Cys Cys Asn Ser Asp Gly Ala Leu 
            900                 905                 910         



Leu Arg Phe Tyr Val Arg Val Leu Gln Lys Glu Leu Ala Ala Ser Thr 
        915                 920                 925             


Ser Glu Asp Thr His Pro Tyr Lys Glu Glu Leu Glu Thr Ala Leu Glu 
    930                 935                 940                 


Gln Cys Phe Tyr Cys Leu Tyr Ser Phe Pro Ser Lys Lys Ser Lys Ala 
945                 950                 955                 960 


Arg Tyr Leu Glu Glu His Ser Ala Gln Gln Val Asp Leu Ile Trp Glu 
                965                 970                 975     


Asp Ala Leu Phe Met Phe Glu Tyr Phe Lys Pro Lys Thr Leu Pro Glu 
            980                 985                 990         


Phe Asp Ser Tyr Lys Thr Ser Thr  Val Ser Ala Asp Leu  Ala Asn Leu 
        995                 1000                 1005             


Leu Lys  Arg Ile Ala Thr Ile  Val Pro Arg Thr Glu  Arg Pro Ala 
    1010                 1015                 1020             


Leu Ser  Leu Asp Lys Val Ser  Ala Tyr Ile Glu Gly  Thr Ser Thr 
    1025                 1030                 1035             


Glu Val  Pro Cys Leu Pro Glu  Gly Ala Asp Pro Ser  Pro Pro Val 
    1040                 1045                 1050             


Val Asn  Glu Leu Tyr Tyr Leu  Leu Ala Asp Tyr His  Phe Lys Asn 
    1055                 1060                 1065             


Lys Glu  Gln Ser Lys Ala Ile  Lys Phe Tyr Met His  Asp Ile Cys 
    1070                 1075                 1080             


Ile Cys  Pro Asn Arg Phe Asp  Ser Trp Ala Gly Met  Ala Leu Ala 
    1085                 1090                 1095             


Arg Ala  Ser Arg Ile Gln Asp  Lys Leu Asn Ser Asn  Glu Leu Lys 
    1100                 1105                 1110             


Ser Asp  Gly Pro Ile Trp Lys  His Ala Thr Pro Val  Leu Asn Cys 
    1115                 1120                 1125             



Phe Arg  Arg Ala Leu Glu Ile  Asp Ser Ser Asn Leu  Ser Leu Trp 
    1130                 1135                 1140             


Ile Glu  Tyr Gly Thr Met Ser  Tyr Ala Leu His Ser  Phe Ala Ser 
    1145                 1150                 1155             


Arg Gln  Leu Lys Gln Trp Arg  Gly Glu Leu Pro Pro  Glu Leu Val 
    1160                 1165                 1170             


Gln Gln  Met Glu Gly Arg Arg  Asp Ser Met Leu Glu  Thr Ala Lys 
    1175                 1180                 1185             


His Cys  Phe Thr Ser Ala Ala  Arg Cys Glu Gly Asp  Gly Asp Glu 
    1190                 1195                 1200             


Glu Glu  Trp Leu Ile His Tyr  Met Leu Gly Lys Val  Ala Glu Lys 
    1205                 1210                 1215             


Gln Gln  Gln Pro Pro Thr Val  Tyr Leu Leu His Tyr  Arg Gln Ala 
    1220                 1225                 1230             


Gly His  Tyr Leu His Glu Glu  Ala Ala Arg Tyr Pro  Lys Lys Ile 
    1235                 1240                 1245             


His Tyr  His Asn Pro Pro Glu  Leu Ala Met Glu Ala  Leu Glu Val 
    1250                 1255                 1260             


Tyr Phe  Arg Leu His Ala Ser  Ile Leu Lys Leu Leu  Gly Lys Pro 
    1265                 1270                 1275             


Asp Ser  Gly Val Gly Ala Glu  Val Leu Val Asn Phe  Met Lys Glu 
    1280                 1285                 1290             


Ala Ala  Glu Gly Pro Phe Ala  Arg Gly Glu Glu Lys  Asn Thr Pro 
    1295                 1300                 1305             


Lys Ala  Ser Glu Lys Glu Lys  Ala Cys Leu Val Asp  Glu Asp Ser 
    1310                 1315                 1320             


His Ser  Ser Ala Gly Thr Leu  Pro Gly Pro Gly Ala  Ser Leu Pro 
    1325                 1330                 1335             



Ser Ser  Ser Gly Pro Gly Leu  Thr Ser Pro Pro Tyr  Thr Ala Thr 
    1340                 1345                 1350             


Pro Ile  Asp His Asp Tyr Val  Lys Cys Lys Lys Pro  His Gln Gln 
    1355                 1360                 1365             


Ala Thr  Pro Asp Asp Arg Ser  Gln Asp Ser Thr Ala  Val Ala Leu 
    1370                 1375                 1380             


Ser Asp  Ser Ser Ser Thr Gln  Asp Phe Phe Asn Glu  Pro Thr Ser 
    1385                 1390                 1395             


Leu Leu  Glu Gly Ser Arg Lys  Ser Tyr Thr Glu Lys  Arg Leu Pro 
    1400                 1405                 1410             


Ile Leu  Ser Ser Gln Ala Gly  Ala Thr Gly Lys Asp  Leu Gln Gly 
    1415                 1420                 1425             


Ala Thr  Glu Glu Arg Gly Lys  Asn Glu Glu Ser Leu  Glu Ser Thr 
    1430                 1435                 1440             


Glu Gly  Phe Arg Ala Ala Glu  Gln Gly Val Gln Lys  Pro Ala Ala 
    1445                 1450                 1455             


Glu Thr  Pro Ala Ser Ala Cys  Ile Pro Gly Lys Pro  Ser Ala Ser 
    1460                 1465                 1470             


Thr Pro  Thr Leu Trp Asp Gly  Lys Lys Arg Gly Asp  Leu Pro Gly 
    1475                 1480                 1485             


Glu Pro  Val Ala Phe Pro Gln  Gly Leu Pro Ala Gly  Ala Glu Glu 
    1490                 1495                 1500             


Gln Arg  Gln Phe Leu Thr Glu  Gln Cys Ile Ala Ser  Phe Arg Leu 
    1505                 1510                 1515             


Cys Leu  Ser Arg Phe Pro Gln  His Tyr Lys Ser Leu  Tyr Arg Leu 
    1520                 1525                 1530             


Ala Phe  Leu Tyr Thr Tyr Ser  Lys Thr His Arg Asn  Leu Gln Trp 
    1535                 1540                 1545             



Ala Arg  Asp Val Leu Leu Gly  Ser Ser Ile Pro Trp  Gln Gln Leu 
    1550                 1555                 1560             


Gln His  Met Pro Ala Gln Gly  Leu Phe Cys Glu Arg  Asn Lys Thr 
    1565                 1570                 1575             


Asn Phe  Phe Asn Gly Ile Trp  Arg Ile Pro Val Asp  Glu Ile Asp 
    1580                 1585                 1590             


Arg Pro  Gly Ser Phe Ala Trp  His Met Asn Arg Ser  Ile Val Leu 
    1595                 1600                 1605             


Leu Leu  Lys Val Leu Ala Gln  Leu Arg Asp His Ser  Thr Leu Leu 
    1610                 1615                 1620             


Lys Val  Ser Ser Met Leu Gln  Arg Thr Pro Asp Gln  Gly Lys Lys 
    1625                 1630                 1635             


Tyr Leu  Arg Asp Ala Asp Arg  Gln Val Leu Ala Gln  Arg Ala Phe 
    1640                 1645                 1650             


Ile Leu  Thr Val Lys Val Leu  Glu Asp Thr Leu Ser  Glu Leu Ala 
    1655                 1660                 1665             


Glu Gly  Ser Glu Arg Pro Gly  Pro Lys Val Cys Gly  Leu Pro Gly 
    1670                 1675                 1680             


Ala Arg  Met Thr Thr Asp Val  Ser His Lys Ala Ser  Pro Glu Asp 
    1685                 1690                 1695             


Gly Gln  Glu Gly Leu Pro Gln  Pro Lys Lys Pro Pro  Leu Ala Asp 
    1700                 1705                 1710             


Gly Ser  Gly Pro Gly Pro Glu  Pro Gly Gly Lys Val  Gly Leu Leu 
    1715                 1720                 1725             


Asn His  Arg Pro Val Ala Met  Asp Ala Gly Asp Ser  Ala Asp Gln 
    1730                 1735                 1740             


Ser Gly  Glu Arg Lys Asp Lys  Glu Ser Pro Arg Ala  Gly Pro Thr 
    1745                 1750                 1755             



Glu Pro  Met Asp Thr Ser Glu  Ala Thr Val Cys His  Ser Asp Leu 
    1760                 1765                 1770             


Glu Arg  Thr Pro Pro Leu Leu  Pro Gly Arg Pro Ala  Arg Asp Arg 
    1775                 1780                 1785             


Gly Pro  Glu Ser Arg Pro Thr  Glu Leu Ser Leu Glu  Glu Leu Ser 
    1790                 1795                 1800             


Ile Ser  Ala Arg Gln Gln Pro  Thr Pro Leu Thr Pro  Ala Gln Pro 
    1805                 1810                 1815             


Ala Pro  Ala Pro Ala Pro Ala  Thr Thr Thr Gly Thr  Arg Ala Gly 
    1820                 1825                 1830             


Gly His  Pro Glu Glu Pro Leu  Ser Arg Leu Ser Arg  Lys Arg Lys 
    1835                 1840                 1845             


Leu Leu  Glu Asp Thr Glu Ser  Gly Lys Thr Leu Leu  Leu Asp Ala 
    1850                 1855                 1860             


Tyr Arg  Val Trp Gln Gln Gly  Gln Lys Gly Val Ala  Tyr Asp Leu 
    1865                 1870                 1875             


Gly Arg  Val Glu Arg Ile Met  Ser Glu Thr Tyr Met  Leu Ile Lys 
    1880                 1885                 1890             


Gln Val  Asp Glu Glu Ala Ala  Leu Glu Gln Ala Val  Lys Phe Cys 
    1895                 1900                 1905             


Gln Val  His Leu Gly Ala Ala  Ala Gln Arg Gln Ala  Ser Gly Asp 
    1910                 1915                 1920             


Thr Pro  Thr Thr Pro Lys His  Pro Lys Asp Ser Arg  Glu Asn Phe 
    1925                 1930                 1935             


Phe Pro  Val Thr Val Val Pro  Thr Ala Pro Asp Pro  Val Pro Ala 
    1940                 1945                 1950             


Asp Ser  Val Gln Arg Pro Ser  Asp Ala His Thr Lys  Pro Arg Pro 
    1955                 1960                 1965             



Ala Leu  Ala Ala Ala Thr Thr  Ile Ile Thr Cys Pro  Pro Ser Ala 
    1970                 1975                 1980             


Ser Ala  Ser Thr Leu Asp Gln  Ser Lys Asp Pro Gly  Pro Pro Arg 
    1985                 1990                 1995             


Pro His  Arg Pro Glu Ala Thr  Pro Ser Met Ala Ser  Leu Gly Pro 
    2000                 2005                 2010             


Glu Gly  Glu Glu Leu Ala Arg  Val Ala Glu Gly Thr  Ser Phe Pro 
    2015                 2020                 2025             


Pro Gln  Glu Pro Arg His Ser  Pro Gln Val Lys Met  Ala Pro Thr 
    2030                 2035                 2040             


Ser Ser  Pro Ala Glu Pro His  Cys Trp Pro Ala Glu  Ala Ala Leu 
    2045                 2050                 2055             


Gly Thr  Gly Ala Glu Pro Thr  Cys Ser Gln Glu Gly  Lys Leu Arg 
    2060                 2065                 2070             


Pro Glu  Pro Arg Arg Asp Gly  Glu Ala Gln Glu Ala  Ala Ser Glu 
    2075                 2080                 2085             


Thr Gln  Pro Leu Ser Ser Pro  Pro Thr Ala Ala Ser  Ser Lys Ala 
    2090                 2095                 2100             


Pro Ser  Ser Gly Ser Ala Gln  Pro Pro Glu Gly His  Pro Gly Lys 
    2105                 2110                 2115             


Pro Glu  Pro Ser Arg Ala Lys  Ser Arg Pro Leu Pro  Asn Met Pro 
    2120                 2125                 2130             


Lys Leu  Val Ile Pro Ser Ala  Ala Thr Lys Phe Pro  Pro Glu Ile 
    2135                 2140                 2145             


Thr Val  Thr Pro Pro Thr Pro  Thr Leu Leu Ser Pro  Lys Gly Ser 
    2150                 2155                 2160             


Ile Ser  Glu Glu Thr Lys Gln  Lys Leu Lys Ser Ala  Ile Leu Ser 
    2165                 2170                 2175             



Ala Gln  Ser Ala Ala Asn Val  Arg Lys Glu Ser Leu  Cys Gln Pro 
    2180                 2185                 2190             


Ala Leu  Glu Val Leu Glu Thr  Ser Ser Gln Glu Ser  Ser Leu Glu 
    2195                 2200                 2205             


Ser Glu  Thr Asp Glu Asp Asp  Asp Tyr Met Asp Ile  
    2210                 2215                 2220 


<210>  10
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Ser Arg Ala Ser Thr Leu Leu Arg Asp Glu Glu Leu Glu Glu 
1               5                   10                  15      


Ile Lys Lys Glu Thr Gly Phe Ser His Ser Gln Ile Thr Arg Leu Tyr 
            20                  25                  30          


Ser Arg Phe Thr Ser Leu Asp Lys Gly Glu Asn Gly Thr Leu Ser Arg 
        35                  40                  45              


Glu Asp Phe Gln Arg Ile Pro Glu Leu Ala Ile Asn Pro Leu Gly Asp 
    50                  55                  60                  


Arg Ile Ile Asn Ala Phe Phe Pro Glu Gly Glu Asp Gln Val Asn Phe 
65                  70                  75                  80  


Arg Gly Phe Met Arg Thr Leu Ala His Phe Arg Pro Ile Glu Asp Asn 
                85                  90                  95      


Glu Lys Ser Lys Asp Val Asn Gly Pro Glu Pro Leu Asn Ser Arg Ser 
            100                 105                 110         



Asn Lys Leu His Phe Ala Phe Arg Leu Tyr Asp Leu Asp Lys Asp Glu 
        115                 120                 125             


Lys Ile Ser Arg Asp Glu Leu Leu Gln Val Leu Arg Met Met Val Gly 
    130                 135                 140                 



Val Asn Ile Ser Asp Glu Gln Leu Gly Ser Ile Ala Asp Arg Thr Ile 
145                 150                 155                 160 


Gln Glu Ala Asp Gln Asp Gly Asp Ser Ala Ile Ser Phe Thr Glu Phe 
                165                 170                 175     


Val Lys Val Leu Glu Lys Val Asp Val Glu Gln Lys Met Ser Ile Arg 
            180                 185                 190         


Phe Leu His 
        195 


<210>  11
<211>  195
<212>  PRT
<213>  Bos taurus

<400>  11

Met Gly Ser Arg Ala Ser Thr Leu Leu Arg Asp Glu Glu Leu Glu Glu 
1               5                   10                  15      


Ile Lys Lys Glu Thr Gly Phe Ser His Ser Gln Ile Thr Arg Leu Tyr 
            20                  25                  30          


Ser Arg Phe Thr Ser Leu Asp Lys Gly Glu Asn Gly Thr Leu Ser Arg 
        35                  40                  45              


Glu Asp Phe Gln Arg Ile Pro Glu Leu Ala Ile Asn Pro Leu Gly Asp 
    50                  55                  60                  


Arg Ile Ile Asn Ala Phe Phe Pro Glu Gly Glu Asp Gln Val Asn Phe 
65                  70                  75                  80  


Arg Gly Phe Met Arg Thr Leu Ala His Phe Arg Pro Ile Glu Asp Asn 
                85                  90                  95      



Glu Lys Ser Lys Asp Val Asn Gly Pro Glu Pro Leu Asn Ser Arg Ser 
            100                 105                 110         


Asn Lys Leu His Phe Ala Phe Arg Leu Tyr Asp Leu Asp Lys Asp Asp 
        115                 120                 125             



Lys Ile Ser Arg Asp Glu Leu Leu Gln Val Leu Arg Met Met Val Gly 
    130                 135                 140                 


Val Asn Ile Ser Asp Glu Gln Leu Gly Ser Ile Ala Asp Arg Thr Ile 
145                 150                 155                 160 


Gln Glu Ala Asp Gln Asp Gly Asp Ser Ala Ile Ser Phe Thr Glu Phe 
                165                 170                 175     


Val Lys Val Leu Glu Lys Val Asp Val Glu Gln Lys Met Ser Ile Arg 
            180                 185                 190         


Phe Leu His 
        195 


<210>  12
<211>  195
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Met Gly Ser Arg Ala Ser Thr Leu Leu Arg Asp Glu Glu Leu Glu Glu 
1               5                   10                  15      


Ile Lys Lys Glu Thr Gly Phe Ser His Ser Gln Ile Thr Arg Leu Tyr 
            20                  25                  30          


Ser Arg Phe Thr Ser Leu Asp Lys Gly Glu Asn Gly Thr Leu Ser Arg 
        35                  40                  45              


Glu Asp Phe Gln Arg Ile Pro Glu Leu Ala Ile Asn Pro Leu Gly Asp 
    50                  55                  60                  


Arg Ile Ile Asn Ala Phe Phe Ser Glu Gly Glu Asp Gln Val Asn Phe 
65                  70                  75                  80  



Arg Gly Phe Met Arg Thr Leu Ala His Phe Arg Pro Ile Glu Asp Asn 
                85                  90                  95      


Glu Lys Ser Lys Asp Val Asn Gly Pro Glu Pro Leu Asn Ser Arg Ser 
            100                 105                 110         



Asn Lys Leu His Phe Ala Phe Arg Leu Tyr Asp Leu Asp Lys Asp Asp 
        115                 120                 125             


Lys Ile Ser Arg Asp Glu Leu Leu Gln Val Leu Arg Met Met Val Gly 
    130                 135                 140                 


Val Asn Ile Ser Asp Glu Gln Leu Gly Ser Ile Ala Asp Arg Thr Ile 
145                 150                 155                 160 


Gln Glu Ala Asp Gln Asp Gly Asp Ser Ala Ile Ser Phe Thr Glu Phe 
                165                 170                 175     


Val Lys Val Leu Glu Lys Val Asp Val Glu Gln Lys Met Ser Ile Arg 
            180                 185                 190         


Phe Leu His 
        195 


<210>  13
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Ser Arg Ser Ser His Ala Ala Val Ile Pro Asp Gly Asp Ser 
1               5                   10                  15      


Ile Arg Arg Glu Thr Gly Phe Ser Gln Ala Ser Leu Leu Arg Leu His 
            20                  25                  30          


His Arg Phe Arg Ala Leu Asp Arg Asn Lys Lys Gly Tyr Leu Ser Arg 
        35                  40                  45              


Met Asp Leu Gln Gln Ile Gly Ala Leu Ala Val Asn Pro Leu Gly Asp 
    50                  55                  60                  



Arg Ile Ile Glu Ser Phe Phe Pro Asp Gly Ser Gln Arg Val Asp Phe 
65                  70                  75                  80  


Pro Gly Phe Val Arg Val Leu Ala His Phe Arg Pro Val Glu Asp Glu 
                85                  90                  95      



Asp Thr Glu Thr Gln Asp Pro Lys Lys Pro Glu Pro Leu Asn Ser Arg 
            100                 105                 110         


Arg Asn Lys Leu His Tyr Ala Phe Gln Leu Tyr Asp Leu Asp Arg Asp 
        115                 120                 125             


Gly Lys Ile Ser Arg His Glu Met Leu Gln Val Leu Arg Leu Met Val 
    130                 135                 140                 


Gly Val Gln Val Thr Glu Glu Gln Leu Glu Asn Ile Ala Asp Arg Thr 
145                 150                 155                 160 


Val Gln Glu Ala Asp Glu Asp Gly Asp Gly Ala Val Ser Phe Val Glu 
                165                 170                 175     


Phe Thr Lys Ser Leu Glu Lys Met Asp Val Glu Gln Lys Met Ser Ile 
            180                 185                 190         


Arg Ile Leu Lys 
        195     


<210>  14
<211>  196
<212>  PRT
<213>  Mus musculus

<400>  14

Met Gly Ser Arg Ser Ser His Ile Ala Leu Ile Pro Asp Val Glu His 
1               5                   10                  15      


Ile Arg Arg Glu Thr Gly Phe Ser Gln Ala Ser Leu Leu Arg Leu Tyr 
            20                  25                  30          


His Arg Phe Gln Ala Leu Asp Arg Asp Glu Lys Gly Phe Leu Ser Arg 
        35                  40                  45              



Leu Asp Leu Gln Gln Ile Gly Ala Leu Ala Val Asn Pro Leu Gly Asp 
    50                  55                  60                  


Arg Ile Ile Asp Ser Phe Phe Pro Asn Gly Ser Gln Arg Leu Tyr Phe 
65                  70                  75                  80  



Ala Gly Phe Ala Arg Val Leu Ala Tyr Phe Arg Pro Ile Asp Glu Glu 
                85                  90                  95      


Asp Ala Thr Leu Arg Asp Pro Lys Gln Pro Glu Pro Leu Asn Ser Arg 
            100                 105                 110         


Met Asn Lys Leu Arg Phe Ala Phe Gln Leu Tyr Asp Leu Asp Arg Asp 
        115                 120                 125             


Gly Lys Ile Ser Arg Asn Glu Met Leu Gln Val Leu Arg Leu Met Val 
    130                 135                 140                 


Gly Val Gln Val Thr Asp Glu Gln Leu Glu Ser Ile Thr Asp Arg Thr 
145                 150                 155                 160 


Val Gln Glu Ala Asp Glu Asp Gly Asp Gly Ala Val Ser Phe Leu Glu 
                165                 170                 175     


Phe Thr Lys Ser Leu Glu Lys Met Asn Ile Glu Gln Lys Met Gly Ile 
            180                 185                 190         


Arg Ile Leu Lys 
        195     


<210>  15
<211>  238
<212>  PRT
<213>  African swine fever virus

<400>  15

Met Glu His Met Phe Pro Glu Arg Glu Ile Glu Asn Leu Phe Val Lys 
1               5                   10                  15      


Trp Ile Lys Lys His Ile Arg Asn Gly Asn Leu Thr Leu Phe Glu Glu 
            20                  25                  30          



Phe Phe Lys Thr Asp Pro Trp Ile Val Asn Arg Cys Asp Lys Asn Gly 
        35                  40                  45              


Ser Ser Val Phe Met Trp Ile Cys Ile Tyr Gly Arg Ile Asp Phe Leu 
    50                  55                  60                  



Lys Phe Leu Phe Glu Gln Glu Ser Tyr Pro Gly Glu Ile Ile Asn Pro 
65                  70                  75                  80  


His Arg Arg Asp Lys Asp Gly Asn Ser Ala Leu His Tyr Leu Ala Glu 
                85                  90                  95      


Lys Lys Asn His Leu Ile Leu Glu Glu Val Leu Gly Tyr Phe Gly Lys 
            100                 105                 110         


Asn Gly Thr Lys Ile Cys Leu Pro Asn Phe Asn Gly Met Thr Pro Val 
        115                 120                 125             


Met Lys Ala Ala Ile Arg Gly Arg Thr Ser Asn Val Leu Ser Leu Ile 
    130                 135                 140                 


Lys Phe Gly Ala Asp Pro Thr Gln Lys Asp Tyr His Arg Gly Phe Thr 
145                 150                 155                 160 


Ala Trp Asp Trp Ala Val Phe Thr Gly Asn Met Glu Leu Val Lys Ser 
                165                 170                 175     


Leu Asn His Asp Tyr Gln Lys Pro Leu Tyr Met His Phe Pro Leu Tyr 
            180                 185                 190         


Lys Leu Asp Val Phe His Arg Trp Phe Lys Lys Lys Pro Lys Ile Ile 
        195                 200                 205             


Ile Thr Gly Cys Lys Asn Asn Val Tyr Glu Lys Leu Pro Glu Gln Asn 
    210                 215                 220                 


Pro Asn Phe Leu Cys Val Lys Lys Leu Asn Lys Tyr Gly Lys 
225                 230                 235             


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pptido derivado de NFAT

<400>  16

Asp Gln Phe Leu Ser Val Pro Ser Pro Phe Thr Trp Ser Lys Pro 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pptido derivado de NFAT

<400>  17

Asp Gln Tyr Leu Ala Val Pro Gln His Pro Tyr Gln Trp Ala Lys 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pptido derivado de NFAT

<400>  18

Met Asp Tyr Leu Ala Val Pro Ser Pro Leu Ala Trp Ser Lys Ala 
1               5                   10                  15  


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pptido mimtico ApoE


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  19

Ala Ser Xaa Leu Arg Lys Leu Xaa Lys Arg Leu Leu 
1               5                   10          


<210>  20
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pptido mimtico de ApoE


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa es nitroarginina

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  AMIDATION

<400>  20

Leu Arg Val Arg Leu Ala Ser Xaa Leu Arg Lys Leu Arg Lys Xaa Ala 
1               5                   10                  15      


Ala Leu Leu 
            


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pptido mimtico de ApoE


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  AMIDATION

<400>  21

Leu Arg Val Arg Leu Ala Ser Xaa Leu Arg Lys Leu Arg Lys Arg Leu 
1               5                   10                  15      


Leu 
    


<210>  22
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pptido mimtico ApoE


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  AMIDATION

<400>  22

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Cys Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Arg Lys Arg 
            20                  25                  30          


Leu Leu 
        


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pptido derivado de ApoE


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION, Aib

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  23

Xaa Leu Arg Lys Leu Xaa Lys Arg Leu Leu 
1               5                   10  


<210>  24
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pptido mimtico ApoE


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  AMIDATION

<400>  24

Arg Arg Leu Ser Tyr Ser Arg Arg Arg Phe Leu Arg Val Arg Leu Ala 
1               5                   10                  15      


Ser His Leu Arg Lys Leu Arg Lys Arg Leu Leu 
            20                  25          


<210>  25
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA de la subunidad reguladora de calcineurina


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  deoxi timidina

<400>  25
cagaguauuu cacguuuaan n                                                 21


<210>  26
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA de la subunidad cataltica calcineurina


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  deoxi timidina

<400>  26
uucuucagaa caucaacccn n                                                 21


<210>  27
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA de la subunidad cataltica de calcineurina


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  deoxi timidina

<400>  27
ggguugaugu ucugaagaan n                                                 21


<210>  28
<211>  2276
<212>  DNA
<213>  Homo sapiens

<400>  28
ccagctcaga gcctagacct ccagccgagc ggtttgcagc cgcgggcggc ggcggcggcg       60

gcggcgttga gtgtctggcc cgccggtccg gtcggggtgt gcagtcggac ggacgagcag      120

cgcgtcgctg tcctccggca gctggagatg tccgagccca aggcaattga tcccaagttg      180

tcgacgaccg acagggtggt gaaagctgtt ccatttcctc caagtcaccg gcttacagca      240

aaagaagtgt ttgataatga tggaaaacct cgtgtggata tcttaaaggc gcatcttatg      300

aaggagggaa ggctggaaga gagtgttgca ttgagaataa taacagaggg tgcatcaatt      360

cttcgacagg aaaaaaattt gctggatatt gatgcgccag tcactgtttg tggggacatt      420

catggacaat tctttgattt gatgaagctc tttgaagtcg ggggatctcc tgccaacact      480

cgctacctct tcttagggga ctatgttgac agagggtact tcagtattga atgtgtgctg      540

tatttgtggg ccttgaaaat tctctacccc aaaacactgt ttttacttcg tggaaatcat      600

gaatgtagac atctaacaga gtatttcaca tttaaacaag aatgtaaaat aaagtattca      660

gaacgagtat atgatgcctg tatggatgcc tttgactgcc ttcccctggc tgccctgatg      720

aaccaacagt tcctgtgtgt gcatggtggt ttgtctccag agattaacac tttagatgat      780

atcagaaaat tagaccgatt caaagaacca cctgcatatg gacctatgtg tgatatcctg      840

tggtcagacc ccctggaaga ttttggaaat gagaagactc aggaacattt cactcacaac      900

acagtcaggg ggtgttcata cttctacagt tacccggctg tatgtgaatt cttacagcac      960

aataacttgt tatctatact ccgagcccac gaagcccaag atgcagggta ccgcatgtac     1020

aggaaaagcc aaacaacagg cttcccttct ctaattacaa ttttttcagc accaaattac     1080

ttagatgtat acaataacaa agctgcagta ttgaagtatg agaacaatgt tatgaatatc     1140

aggcaattca actgttctcc tcatccatac tggcttccaa atttcatgga tgtttttact     1200

tggtcccttc catttgttgg ggaaaaagtg actgagatgc tggtaaatgt cctcaacatc     1260

tgctcagatg atgaactagg gtcagaagaa gatggatttg atggtgcaac agctgcagcc     1320

cggaaagagg tgataaggaa caagatccga gcaataggca aaatggccag agtgttctca     1380

gtgctcagag aagagagtga gagtgtgctg acgctgaaag gcttgacccc aactggcatg     1440

ctccccagcg gagtactttc tggagggaag caaaccctgc aaagcgctac tgttgaggct     1500

attgaggctg atgaagctat caaaggattt tcaccacaac ataagatcac tagcttcgag     1560

gaagccaagg gcttagaccg aattaatgag aggatgccgc ctcgcagaga tgccatgccc     1620

tctgacgcca accttaactc catcaacaag gctctcacct cagagactaa cggcacggac     1680

agcaatggca gtaatagcag caatattcag tgaccacttc ctgttcacat tttttttttt     1740

tttttttttt tttttttttt tgagctgcgg ggcatgatgg ggattgctgc atatcagcag     1800

ttggatgttc ttgcctctga cagtagctta tttgctctgg gggccaggaa ttggattcag     1860

tttacactat cattaaaaaa gagggagaga gataataaac tatattttgg tggggatggt     1920

gattaaacac ctcttttggg tatgcctttt aaaaatgctt atagagaaaa aaaattttaa     1980

aaaaagaaag ctaatgctag tatatactgc aatgttaggg gaatgaacat gttttcctac     2040

tgcattgggg acttctagat aggttaatga aaggcctttt attctgttac tggacatgaa     2100

aactttgtct aatttcttac tctattgtac gtttacagtc gcagcactaa aaatggatga     2160

catcaaacat ttttaacaaa atgatgatgt acaaactaag gactatttat tgataatgtt     2220

ttgctactct tgtcagacaa tggctataaa ctgaattagg cagtcttaaa aaaaaa         2276


<210>  29
<211>  2337
<212>  DNA
<213>  Rattus norvegicus

<400>  29
cgggaggagg agtgaaggcg gcggcggcgg aggagggacg cgcggagccg gcagtaactt       60

tcgagccagc ccagagcccg gagctccagc cgagcggttt gcagcgcggc ggcgcggcgc      120

tgagtgtctg gcccgccggt gcggtcgggg tgtgcagtcg gacgggacca gcagcgcgtc      180

gctgtccccc cctcccggtg actggagatg tccgagccca aggcgattga tcccaagttg      240

tcgactacgg acagggtggt gaaagccgtt ccatttccgc caagtcaccg gctgacagca      300

aaggaagtgt ttgataacga tgggaagcct cgtgtggata tcttaaaagc acatctcatg      360

aaggaaggca ggctggaaga aagtgtcgcg ttgagaataa taacagaggg tgcttcgatt      420

ctccgacagg aaaaaaactt gctggatatt gatgccccag tcacagtttg cggggacatc      480

catggacaat tctttgactt gatgaagctc tttgaagtgg gaggatctcc tgccaacact      540

cgctacctct tcttagggga ctatgttgac agagggtact tcagtatcga atgtgtgctg      600

tatttgtggg ccttgaaaat tctttacccc aaaacactgt ttttacttcg tggaaaccat      660

gaatgtaggc acctaacaga gtatttcacg tttaaacaag aatgtaaaat aaagtattca      720

gaacgcgttt atgacgcctg tatggatgcc ttcgactgcc ttcccctggc tgcgctgatg      780

aaccaacaat tcctgtgtgt acacggtggt ttgtctccag agattaacac tctagatgac      840

atcagaaaat tagaccgatt caaagaacca cctgcttatg ggcctatgtg tgacatcttg      900

tggtcagacc ccctggagga ctttggaaat gagaagactc aggaacattt cactcacaac      960

acagtcaggg gttgttcgta cttctacagt tacccggctg tatgtgactt cctgcagcac     1020

aataatttgt tgtccatact ccgagcccac gaagcccagg acgcagggta ccgcatgtac     1080

aggaaaagcc aaacaactgg cttcccgtct ctaattacga tcttctcggc accaaattac     1140

ttagatgtgt acaataataa agctgcagtg ttgaagtacg agaacaacgt gatgaacatc     1200

aggcagttca actgctcccc ccatccgtac tggctcccaa atttcatgga tgttttcacc     1260

tggtcgctgc catttgttgg ggagaaagtg actgagatgc tggtaaacgt cctgaacatc     1320

tgctcagatg atgaactggg gtcagaagaa gatggatttg acggagccac ggctgcagcc     1380

cggaaggagg tcatcaggaa caagatccga gcaataggca aaatggccag agtattctca     1440

gttctcagag aagagagtga gagcgttcta actctgaagg gcctgacccc gactggcatg     1500

ctccccagcg gagtgctctc tggcgggaaa caaactctgc aaagcgctac tgttgaggcc     1560

attgaggctg atgaagccat caaaggattc tcaccacaac ataagattac cagcttcgag     1620

gaggccaagg gcttagaccg aattaacgag aggatgccgc ctcgcagaga cgccatgcct     1680

tccgacgcca accttaactc catcaacaag gctctcgcct cagagactaa cggcacagac     1740

agcaacggca gtaatagcag caatattcag tgaccacttc ctgttcactt tttttttttg     1800

agctgcaggg catgatgggt ttgctgcatc tcagcagttg gatgttcttg cctctgacgg     1860

tagcttgttt gctctggggg ggccaggaat tggattcagt ttacactatc atgaaaaaaa     1920

aaaagaggga gagagagaga gataataaaa ctatattttg gtgagggtgg tgattaaaca     1980

cctcttttgg gtatgccttt aaaaatgctt ctaggaaaaa aaaagtttta aaaagaaagc     2040

taatgctagt ctatacttca atgttagggg aatgaacacg ttttcctagc gcactgggga     2100

cttttagata ggttaatgaa aggcctttta ttctgttact ggacacgaaa actttgtcta     2160

atttcttata ctctattgta cgtttacagt cgcagcacta aaaatggatg acatcaaaca     2220

tttttaaaca gaaaaaaaag atgtacaaac taaataagga ctatttattg ataatgtttt     2280

gctactcttg tcagacaatg gctataaact gaattaggca gtcttaaaaa aaaaccg        2337


<210>  30
<211>  2194
<212>  DNA
<213>  Mus musculus

<400>  30
gcgccggtgc ggtcggggtg tgcagtcgga cgggacgagc agcgcgtcgc tgtccccccc       60

tcccggtggc tggagatgtc cgagcccaag gcgattgatc ccaagttgtc gacgaccgac      120

agggtggtga aagccgttcc atttccacca agtcaccggc tgacagcaaa ggaagtgttt      180

gataatgatg ggaaacctcg tgtggatatc ttaaaagcac atctcatgaa ggagggcagg      240

ctggaagaaa gtgttgcatt gagaataata acagagggtg cttcgattct ccgacaggaa      300

aaaaacttgc tggatatcga cgcaccagtc acagtttgtg gggacatcca tggacaattc      360

tttgacttga tgaagctctt tgaagtggga ggatctcctg ccaacactcg ctacctcttc      420

ttaggggact atgttgacag agggtacttc agtatcgaat gtgtgctgta tttgtgggcc      480

ttgaaaattc tttaccccaa aacactgttt ttacttcgcg gaaaccatga atgtaggcac      540

ctcacagagt atttcacgtt taaacaagaa tgtaaaataa agtattcaga acgcgtttat      600

gacgcctgta tggatgcctt cgactgcctt cccctggctg cgctaatgaa ccagcagttc      660

ctgtgtgtac acggtggttt gtctccagag attaacactc tagatgacat cagaaaatta      720

gaccgattca aagaaccacc tgcttatggg cccatgtgtg acatcctatg gtcagacccc      780

ctggaggact ttggaaatga gaagactcag gaacatttca ctcacaacac agtcagaggc      840

tgttcgtact tctacagtta cccagctgtg tgtgacttcc tgcagcacaa taatttgttg      900

tccatactcc gcgcccacga agcccaggat gcagggtacc gcatgtacag gaaaagccaa      960

acaacaggct tcccgtctct aattacaatc ttctcggcac caaattactt agatgtgtac     1020

aataacaaag ctgcagtgtt gaagtacgag aacaatgtga tgaacatcag gcagttcaac     1080

tgctccccgc atccgtactg gctcccaaat ttcatggatg ttttcacctg gtcgctgcca     1140

tttgttgggg agaaagtgac tgagatgctg gtcaatgttc tcaacatctg ctccgacgat     1200

gaactggggt cagaagaaga tggatttgac ggagccacgg ccgcagcccg gaaggaagtc     1260

atcagaaaca agatccgagc aataggcaaa atggccagag tgttctcagt tctcagagaa     1320

gagagtgaga gtgtcctgac actgaagggc ctgaccccaa ctggcatgct ccccagcgga     1380

gtgctctctg gcgggaaaca gactctgcaa agcgctactg ttgaggctat tgaggctgat     1440

gaagccatca aaggattttc accacaacat aagatcacta gcttcgagga ggccaagggc     1500

ttagaccgaa ttaacgagag gatgccacct cgcagagacg ccatgccctc tgacgccaac     1560

cttaactcca tcaacaaggc tctcgcctca gagactaacg gcacggacag caatggcagt     1620

aatagcagca atatccagtg accacttcct gttcactttt tttttttttt gagctgcagg     1680

gcatgatggg attgctgcat ctcagcagtt ggatgttctt gcctctgaag gtagcttgtt     1740

tgctctgggg gccaggaatt ggattcagtt tacactatca tgaaaaataa aaataaaaaa     1800

agagggagag agataataaa ctatattttg gtgagggtgg tgattaaaca cctcttttgg     1860

gtatgccttt aaaaaatgct tctagggcaa aaaagtttta aaaagaaagc taatgctagc     1920

tatactgcaa tgttagggga atgaacgcgt tttcctactg cactggggac ttttagatag     1980

gttaatgaaa ggcctttatt ctgttactgg acacgaaaac tttgtctaat ttcttatact     2040

ctattgtacc tttacagtcg cagcactaaa atggaagaca tcaaacattt ttaacagaaa     2100

aaaaaaaaga tgtaaaaact aactaaggac tatttattaa tgatgttttg ctactcctgt     2160

cagacaatgg ctataaactg aattaggcag tctt                                 2194


<210>  31
<211>  2327
<212>  DNA
<213>  Bos taurus

<400>  31
cagcggagga ggaggaggag ggacgcgcgg agaaggcagt aactttaaag ccagctcaga       60

gcccagaacc tccagccaag cggtttgcag cgcggcggca gcggcggcgt tgagtgtctg      120

gccccccggt ccggtcgggg tgtgcagtag gacggacgag cagcgcgtcg ctgtcccccg      180

gcggctggag atgtccgagc ccaaggcaat tgatcccaag ttgtcgacga ccgacagggt      240

ggtgaaagct gtcccatttc ctccaagtca ccggcttacg gcaaaagaag tgtttgataa      300

tgatgggaaa cctcgtgtgg atatcttaaa ggcacatctc atgaaggagg gcaggctcga      360

agagactgtc gcattgagaa taataacaga gggggcttca attcttcgac aggaaaaaaa      420

cttgctggat attgatgctc cagtcacagt ttgtggggac atccatggac aattctttga      480

cttgatgaaa ctctttgaag tggggggatc tcctgccaac actcgctacc tcttcttagg      540

ggactatgtt gacagagggt acttcagtat cgaatgtgtg ctgtatttgt gggctttgaa      600

aattctttac cccaaaacac tgtttttact tcgtggaaat catgaatgta gacatctaac      660

agagtatttc acatttaaac aagaatgtaa aataaagtat tcagaacgcg tatatgatgc      720

ctgcatggat gcctttgact gcctgcccct ggctgccctg atgaaccagc agttcctgtg      780

tgtacacggc ggtttgtctc cagagataaa cactttagat gatatcagaa aattagaccg      840

attcaaagaa ccacctgctt atggacctat gtgtgatatc ctgtggtcag acccgctgga      900

agattttgga aacgagaaga ctcaggaaca tttcactcac aacacagtca gggggtgttc      960

atacttctac agttacccgg ctgtatgtga attcttgcag cacaataact tgttatctat     1020

cctccgagct catgaagccc aagatgcagg gtaccgcatg tacaggaaaa gccaaacaac     1080

aggcttcccc tctctcatta caattttttc agcaccaaat tacttagatg tatacaataa     1140

caaagctgca gtattgaagt atgagaacaa tgtcatgaat atcaggcaat tcaactgttc     1200

tcctcatcca tactggcttc caaatttcat ggatgttttc acctggtccc tgccgtttgt     1260

tggggaaaaa gtgactgaga tgctggtaaa tgtcctcaac atatgctcag acgatgaact     1320

agggtcagaa gaagatggat ttgatggagc aacggctgca gccaggaagg aggtgataag     1380

aaataagatc cgagccattg gcaagatggc cagagtgttc tcggttctca gagaagagag     1440

tgagagtgtg ctgacgctga aagggctgac gcccacaggc atgctcccca gcggcgtgct     1500

ttctggaggg aaacaaaccc tgcaaagcgc tactgttgag gctattgagg ctgatgaagc     1560

tatcaaagga ttttcaccac aacataagat cactagcttc gaggaggcca agggcttaga     1620

ccgaattaat gagaggatgc cacctcgcag agatgccatg ccctctgatg ccaaccttaa     1680

ctccatcaac aaggctctcg cctcagagac taacggcacg gacagcaatg gcagtaatag     1740

cagcaatatc cagtgaccac ttcctgttca cctttttttt tttttttttt gatctgcagg     1800

gcctgatggg gatggctgca tatcagcagt tggatattct tgcctctgat ggtagcttat     1860

ttgctctggg gccaggagtt gcattcagtt tacactatca attaaaaaag agagagagag     1920

aattataaac tatattttgg ggggggtggt gattaaacac ctcttttggg tatgcctttt     1980

aaaaaatgct tatagggaaa aaaaaatttt aaaagaaagc taatgctagt atatactgca     2040

atgttagggg aatgtacatg ttttcctact gcattggggg acttctagct aggttaatga     2100

gaggtgcttt tattatgtta ctggacacga aaactttgtc taatttctta ctctattgta     2160

cgtttacagt tgcagcacta aaaatggatg acatcaacca tttttaacaa aatgatgtac     2220

aaactaaata aggactattt atggataatg ttttgctact cttgtcagac aatggctata     2280

aaatgaatta ggcagtctta aaaaaaaaaa aaaaaaaaaa aaacaga                   2327


<210>  32
<211>  3079
<212>  DNA
<213>  Homo sapiens

<400>  32
gggccctaca gagggtccgc catgttcccc ggcggcgccg ccgcttggct ctggtagccg       60

ccgcccccgc ccccaacccc gcccggccca gagcctagcc gagccccggg cccagcatgg      120

ccgccccgga gccggcccgg gctgcaccgc ccccaccccc gcccccgccg ccccctcccg      180

gggctgaccg cgtcgtcaaa gctgtccctt tccccccaac acatcgcttg acatctgaag      240

aagtatttga tttggatggg atacccaggg ttgatgttct gaagaaccac ttggtgaaag      300

aaggtcgagt agatgaagaa attgcgctta gaattatcaa tgagggtgct gccatccttc      360

ggagagagaa aaccatgata gaagtagaag ctccaatcac agtgtgtggt gacatccatg      420

gccaattttt tgatctgatg aaactttttg aagtaggagg atcacctgct aatacacgat      480

acctttttct tggcgattat gtggacagag gttattttag tatagagtgt gtcttatatt      540

tatgggttct gaagattcta tacccaagca cattatttct tctgagaggc aaccatgaat      600

gcagacacct tactgaatat tttaccttta agcaggaatg taaaattaag tattcggaaa      660

gagtctatga agcttgtatg gaagcttttg atagtttgcc tcttgctgca cttttaaacc      720

aacagtttct ttgtgttcat ggtggacttt caccagaaat acacacactg gatgatatta      780

ggagattaga tagattcaaa gagccacctg catttggacc aatgtgtgac ttgttatggt      840

ccgatccttc tgaagatttt ggaaatgaaa aatcacagga acattttagt cacaatacag      900

ttcgaggatg ttcttatttt tataactatc cagcagtgtg tgaatttttg caaaacaata      960

atttgttatc gattattaga gctcatgaag ctcaagatgc aggctataga atgtacagaa     1020

aaagtcaaac tacagggttc ccttcattaa taacaatttt ttcggcacct aattacttag     1080

atgtctacaa taataaagct gctgtattaa agtatgaaaa taatgtgatg aatattcgac     1140

agtttaactg ttctccacat ccttactggt tgcctaattt tatggatgtc ttcacgtggt     1200

ctttaccgtt tgttggagaa aaagtgacag aaatgttggt aaatgttctg agtatttgct     1260

ctgatgatga actaatgact gaaggtgaag accagtttga tggttcagct gcagcccgga     1320

aagaaatcat aagaaacaaa attcgagcaa ttggcaagat ggcaagagtc ttctctgttc     1380

tcagggagga gagtgaaagt gtgctgacac tcaagggcct gactcccaca gggatgttgc     1440

ctagtggagt gttagctgga ggacggcaga ccctgcaaag tgccacagtt gaggctattg     1500

aggctgaaaa agcaatacga ggattctctc caccacatag aatctgcagt tttgaagagg     1560

caaagggttt ggataggatc aatgagagaa tgccacctcg gaaagatgct gtacagcaag     1620

atggtttcaa ttctctgaac accgcacatg ccactgagaa ccacgggacg ggcaaccata     1680

ctgcccagtg acccactact tcccagggac tctcacatct cgggccccaa atggacagat     1740

cacccgagga gctggagggg tcggccaagc tgactgtaaa tttcacagtc tctctgaaga     1800

aaccattgtg cttctgagac cctagccccc ttcctggatg gaggcttgag ggccctggga     1860

catgtgctat ctgataagat tgggtcatcg ctgccaaggt ggagagcagt gagcaagggg     1920

cttggggcaa tttccagtgg agggcatcca cacctccatt ttatgcttgt ggttcacaca     1980

tttaagttta caaatcagat ttcttttccc cttcagtaga attagatttt gtttttcaat     2040

catgatttca aatgcaatcc taagagctaa tgtggacttt tctttttcca tgaaatgtct     2100

ttaaaggatg aattagcatg gtcttaaaat acatttctga ggttactagc tgtattttga     2160

attgtgagca aaatgccgag aaacccagtt ggcatttata caaaatgttg acctcaggtc     2220

tatagttctt aaatgtggct aattctgtaa catagtcttg gtatttttta attatgaatg     2280

catatcctat ttccaggcag gctctcttac ttgaacacaa atccaaaaac taatttagag     2340

tcttttttgc ccagatcttt taagacttac accccagaga tttaagaaga aaacctctaa     2400

atttcaaaat tatgaagaat tacagaatta ctcatttaag gtactttaaa agaagtttgt     2460

acattgtcaa agtaaatttt aattcaaatc atgtctgtaa aacttgacgt attttgtgta     2520

tgcatgtttt cattttgcaa atatttaata tatagaccta tgatgtacag gtacgacatg     2580

tataggttac ctagatgtta tgagaaattt tagtttattg tgagtactca agttgcttag     2640

agagccacca gggtgatttg ctgctggctt tctatcattt ttatgtttta atgcaaagga     2700

aattttaaaa tgttctggaa gtgtttttga ttaagcaatg cagcctagaa gcaatggttc     2760

tgttcaatca ttcagatgtt agtggaagca taaaagtcaa gactgcatgt tgaaaccttt     2820

cttttgatag ttactgaact gcttggttaa actaaatgga accatgtgct aatttttcac     2880

aattattgac ctgtattgat tgccactgta gtttggtatt tccctttact ttggtggcct     2940

gcttccctca tgccctggaa tacaactcag agctccaggc agcggaacca tctattgttt     3000

tgtttgccag aaagtgcacc ctgtatggtc tcctgtctaa gttggaaata ttatgcatgt     3060

gcaggactat tcgagtatt                                                  3079


<210>  33
<211>  3173
<212>  DNA
<213>  Mus musculus

<400>  33
gggtccgcca tgttccccgg cggcgccgcc gcttggctct ggtagccgcc gcccccgccc       60

ccaaccccgc ccgtcccggc acctagccga gccccgggcc cagcatggcc gccccggagc      120

cggcccgggc cgcgccgccc ccgcccccgc ccccaccgcc ccctctcggg gccgaccgcg      180

tcgtcaaagc tgttcctttt cccccaactc atcggctgac atctgaagaa gtgtttgata      240

tggatgggat acccagggtt gatgttctga agaaccactt ggtaaaagaa gggcgggtgg      300

atgaagaaat tgcactaaga attatcaatg agggtgctgc catacttcgg cgggagaaaa      360

ccatgataga agtagaagct ccaattacag tgtgtggtga catccatggc caattttttg      420

atctgatgaa actttttgaa gtaggaggat cacctgctaa tacacgatac ctttttcttg      480

gtgattatgt ggacagaggt tattttagta tagagtgtgt cttatattta tgggtcttga      540

agattctata cccaagcaca ttattccttc tgagaggcaa ccatgaatgc agacacctta      600

ctgaatattt tacctttaag caggaatgta aaattaaata ttcagaaaga gtctatgaag      660

cttgtatgga ggcttttgac agcttgcccc ttgctgcact tctaaaccaa caatttcttt      720

gtgttcatgg tggactttca ccagaaatac acacactgga tgatattagg agattagata      780

gatttaaaga gccacctgca tttggaccaa tgtgtgactt gctatggtct gatccttctg      840

aagactttgg aaatgaaaaa tcacaagaac attttagtca taatacagtt cgaggatgtt      900

cttattttta taactatcca gcagtgtgtg aatttttgca aaacaataat ttgttatcga      960

ttattagagc tcatgaagct caagatgcag gctatagaat gtacagaaaa agtcaaacta     1020

cagggtttcc ttcattaata acaatttttt cggcacctaa ttacttagat gtctacaata     1080

ataaagctgc tgtactaaag tatgaaaata atgtgatgaa cattcgacag tttaattgct     1140

ctccacatcc ttattggttg cccaatttta tggatgtctt tacatggtct ttaccatttg     1200

ttggagaaaa agtgacagaa atgttggtaa atgttctgag tatttgttct gatgatgaac     1260

taatgacaga aggtgaagac cagtttgatg taggttcagc tgcagcccgg aaagaaatca     1320

taagaaacaa gatccgagca attggcaaga tggcaagagt cttctctgtt ctcagggagg     1380

agagtgaaag cgtgctgaca ctcaagggcc tgactcccac agggatgttg cctagtggag     1440

tgttggctgg aggacggcag accttgcaaa gtgccacagt tgaggctatt gaggctgaaa     1500

aagcaatacg aggattctct ccaccacata gaatctgcag ttttgaagag gcaaagggtt     1560

tggataggat caatgagaga atgccacccc ggaaagatgc tgtgcagcaa gatggtttca     1620

attccctgaa caccgcacat accactgaga accacgggac tggcaaccat agtgcccagt     1680

gaccagcggc ttcccaggga ctctcacatc ttgggcccca aatggacaga tcacttcaag     1740

gagctggagg ggttgaccaa ggtgatgata aatgtcataa tctctctgaa gaaaccattg     1800

tgctttctga gatccgtgcc ccccttcctg gatggaggct tgagggccct gggacttgtg     1860

ccgtctataa gattgggtaa tcgctgccac agaggagagc agtgagcaag gggcttgggg     1920

caatttccag tggaggatat ctacacctcc atttatgctt gtggttcaca catttacgtt     1980

tacaaatgag atttcctttg tttttcccct cagtagaatt agacattttt caaccatgac     2040

tttaaataca atctttagag ataacgtgga actcccccca tcaccctcac cccatgaaat     2100

gtctttaaaa ggatggatta gcatggtctt aaaatatatt tctgaggtta ctagatgtat     2160

tttgacttgt agacaaaatc tgagaaaccc agttggtgtt tatataaaat gctgacctca     2220

ggttatagtt cttaaatgtg gctaattctg taacatagtc ttggtatttt tcaattatga     2280

atgcataaac tatttctaag aagactctta cttgaacaaa atccaaaaac caatttagat     2340

tcttttttgc ccatatcttt tgtgatttac accccagaga tttaaggaaa aaacaaaaac     2400

aaaacaaaat gaaattttaa aattatgaag aattacagaa ttactcattt aaggtacttt     2460

aaaagaagtt tgtacattgt caaagtaaat tttaattcaa atcatgtctg taaaacttga     2520

cgtattttgt gtatgcatgt tttcattttg caaatattta atatatagac ctatgatgta     2580

caggtacaac atgtataggt tacgtagata ttatgagaaa ttttagttta ttgtgagtac     2640

tccagttgct ttaaaaacca ccagggtgat ttgctgctgg ctttgtatca tctttatgtt     2700

taaatgcaaa ggaaattaaa aatgtctgga aatgtttttg actaagtaat gcagcctaga     2760

agcaatggtt ctcttcaacc cttcagatgt ctagtggaag cataaaagtc aagactgcat     2820

gtcgaaattt tacttttgat agttacagaa ctgcttggtt aaactaaatg gaaccatgtg     2880

ctaattttac agtgactgac ctgtactgat taccactgta gtttggtatt tccctttact     2940

ttggtggcct gcttccctca tgccctggag tacagctcat agcaccaggc agcggaacca     3000

tctgttgttt tgtttgccag aaagtgcagc ctgtatggtc ttctgtctaa gttggaaata     3060

ttatgcatgt gcaggactat tcaagtattt tataaacagt agcacacaat aaattccatg     3120

catgggcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa            3173


<210>  34
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucletido sentido de calcineurina A1

<400>  34
tgactggaga tgtccgag                                                     18


<210>  35
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucletido antisentido Calcineruina A1

<400>  35
ctcggacatc tccagtca                                                     18


<210>  36
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucletido sentido de calcineurina A2

<400>  36
agcatggccg ccccggag                                                     18


<210>  37
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucletido antisentido de calcineurina A2

<400>  37
ctccggggcg gccatgct                                                     18


<210>  38
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucletido sentido de calcineurina B

<400>  38
gagcaaaatg ggaaatga                                                     18


<210>  39
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucletido antisentido calcineurina B

<400>  39
tcatttccca ttttgctc                                                     18


<210>  40
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA de la subunidad reguladora de calcineurina


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  deoxi timidina

<400>  40
uuaaacguga aauacucugn n                                                 21


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