                               SEQUENCE LISTING	

<110> ASTUTE MEDICAL, INC.
 
<120> METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL 
      INJURY AND RENAL FAILURE

<130> AST-1940-PC

<140> PCT/US2011/001125
<141> 2011-06-23

<150> 61/364,305
<151> 2010-07-14

<150> 61/364,296
<151> 2010-07-14

<150> 61/357,966
<151> 2010-06-23

<150> 61/357,965
<151> 2010-06-23

<150> 61/357,956
<151> 2010-06-23

<160> 35    

<170> PatentIn version 3.5

<210> 1
<211> 99
<212> PRT
<213> Homo sapiens

<400> 1
Met Lys Ala Ser Ala Ala Leu Leu Cys Leu Leu Leu Thr Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gln Pro Val Gly Ile Asn Thr Ser Thr 
            20                  25                  30          


Thr Cys Cys Tyr Arg Phe Ile Asn Lys Lys Ile Pro Lys Gln Arg Leu 
        35                  40                  45              


Glu Ser Tyr Arg Arg Thr Thr Ser Ser His Cys Pro Arg Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Lys Leu Asp Lys Glu Ile Cys Ala Asp Pro Thr Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Phe Met Lys His Leu Asp Lys Lys Thr Gln Thr 
                85                  90                  95      


Pro Lys Leu 
            


<210> 2
<211> 94
<212> PRT
<213> Homo sapiens

<400> 2
Met Met Gly Leu Ser Leu Ala Ser Ala Val Leu Leu Ala Ser Leu Leu 
1               5                   10                  15      


Ser Leu His Leu Gly Thr Ala Thr Arg Gly Ser Asp Ile Ser Lys Thr 
            20                  25                  30          


Cys Cys Phe Gln Tyr Ser His Lys Pro Leu Pro Trp Thr Trp Val Arg 
        35                  40                  45              


Ser Tyr Glu Phe Thr Ser Asn Ser Cys Ser Gln Arg Ala Val Ile Phe 
    50                  55                  60                  


Thr Thr Lys Arg Gly Lys Lys Val Cys Thr His Pro Arg Lys Lys Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Ile Ser Leu Leu Lys Thr Pro Lys Gln Leu 
                85                  90                  


<210> 3
<211> 1744
<212> PRT
<213> Homo sapiens

<400> 3
Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Asp Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Leu  Ser Pro Val Ile His  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Asn Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Ser Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Val Asp Leu Leu  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ser Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Val 
    1445                 1450                 1455             


Val Glu  Glu Gln Glu Ser Arg  Val His Tyr Thr Val  Cys Ile Trp 
    1460                 1465                 1470             


Arg Asn  Gly Lys Val Gly Leu  Ser Gly Met Ala Ile  Ala Asp Val 
    1475                 1480                 1485             


Thr Leu  Leu Ser Gly Phe His  Ala Leu Arg Ala Asp  Leu Glu Lys 
    1490                 1495                 1500             


Leu Thr  Ser Leu Ser Asp Arg  Tyr Val Ser His Phe  Glu Thr Glu 
    1505                 1510                 1515             


Gly Pro  His Val Leu Leu Tyr  Phe Asp Ser Val Pro  Thr Ser Arg 
    1520                 1525                 1530             


Glu Cys  Val Gly Phe Glu Ala  Val Gln Glu Val Pro  Val Gly Leu 
    1535                 1540                 1545             


Val Gln  Pro Ala Ser Ala Thr  Leu Tyr Asp Tyr Tyr  Asn Pro Glu 
    1550                 1555                 1560             


Arg Arg  Cys Ser Val Phe Tyr  Gly Ala Pro Ser Lys  Ser Arg Leu 
    1565                 1570                 1575             


Leu Ala  Thr Leu Cys Ser Ala  Glu Val Cys Gln Cys  Ala Glu Gly 
    1580                 1585                 1590             


Lys Cys  Pro Arg Gln Arg Arg  Ala Leu Glu Arg Gly  Leu Gln Asp 
    1595                 1600                 1605             


Glu Asp  Gly Tyr Arg Met Lys  Phe Ala Cys Tyr Tyr  Pro Arg Val 
    1610                 1615                 1620             


Glu Tyr  Gly Phe Gln Val Lys  Val Leu Arg Glu Asp  Ser Arg Ala 
    1625                 1630                 1635             


Ala Phe  Arg Leu Phe Glu Thr  Lys Ile Thr Gln Val  Leu His Phe 
    1640                 1645                 1650             


Thr Lys  Asp Val Lys Ala Ala  Ala Asn Gln Met Arg  Asn Phe Leu 
    1655                 1660                 1665             


Val Arg  Ala Ser Cys Arg Leu  Arg Leu Glu Pro Gly  Lys Glu Tyr 
    1670                 1675                 1680             


Leu Ile  Met Gly Leu Asp Gly  Ala Thr Tyr Asp Leu  Glu Gly His 
    1685                 1690                 1695             


Pro Gln  Tyr Leu Leu Asp Ser  Asn Ser Trp Ile Glu  Glu Met Pro 
    1700                 1705                 1710             


Ser Glu  Arg Leu Cys Arg Ser  Thr Arg Gln Arg Ala  Ala Cys Ala 
    1715                 1720                 1725             


Gln Leu  Asn Asp Phe Leu Gln  Glu Tyr Gly Thr Gln  Gly Cys Gln 
    1730                 1735                 1740             


Val 
    


<210> 4
<211> 267
<212> PRT
<213> Homo sapiens

<400> 4
Met Pro Arg Ser Cys Cys Ser Arg Ser Gly Ala Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Leu Gln Ala Ser Met Glu Val Arg Gly Trp Cys Leu Glu Ser Ser 
            20                  25                  30          


Gln Cys Gln Asp Leu Thr Thr Glu Ser Asn Leu Leu Glu Cys Ile Arg 
        35                  40                  45              


Ala Cys Lys Pro Asp Leu Ser Ala Glu Thr Pro Met Phe Pro Gly Asn 
    50                  55                  60                  


Gly Asp Glu Gln Pro Leu Thr Glu Asn Pro Arg Lys Tyr Val Met Gly 
65                  70                  75                  80  


His Phe Arg Trp Asp Arg Phe Gly Arg Arg Asn Ser Ser Ser Ser Gly 
                85                  90                  95      


Ser Ser Gly Ala Gly Gln Lys Arg Glu Asp Val Ser Ala Gly Glu Asp 
            100                 105                 110         


Cys Gly Pro Leu Pro Glu Gly Gly Pro Glu Pro Arg Ser Asp Gly Ala 
        115                 120                 125             


Lys Pro Gly Pro Arg Glu Gly Lys Arg Ser Tyr Ser Met Glu His Phe 
    130                 135                 140                 


Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr 
145                 150                 155                 160 


Pro Asn Gly Ala Glu Asp Glu Ser Ala Glu Ala Phe Pro Leu Glu Phe 
                165                 170                 175     


Lys Arg Glu Leu Thr Gly Gln Arg Leu Arg Glu Gly Asp Gly Pro Asp 
            180                 185                 190         


Gly Pro Ala Asp Asp Gly Ala Gly Ala Gln Ala Asp Leu Glu His Ser 
        195                 200                 205             


Leu Leu Val Ala Ala Glu Lys Lys Asp Glu Gly Pro Tyr Arg Met Glu 
    210                 215                 220                 


His Phe Arg Trp Gly Ser Pro Pro Lys Asp Lys Arg Tyr Gly Gly Phe 
225                 230                 235                 240 


Met Thr Ser Glu Lys Ser Gln Thr Pro Leu Val Thr Leu Phe Lys Asn 
                245                 250                 255     


Ala Ile Ile Lys Asn Ala Tyr Lys Lys Gly Glu 
            260                 265         


<210> 5
<211> 188
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Lys Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His 
65                  70                  75                  80  


Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser 
                85                  90                  95      


Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr 
            100                 105                 110         


Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val 
        115                 120                 125             


Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys 
    130                 135                 140                 


Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro 
145                 150                 155                 160 


Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu 
                165                 170                 175     


Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
            180                 185             


<210> 6
<211> 825
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser 
225                 230                 235                 240 


Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr 
                245                 250                 255     


Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
            260                 265                 270         


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
        275                 280                 285             


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
    290                 295                 300                 


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
305                 310                 315                 320 


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
                325                 330                 335     


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            340                 345                 350         


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        355                 360                 365             


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    370                 375                 380                 


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
385                 390                 395                 400 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                405                 410                 415     


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            420                 425                 430         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        435                 440                 445             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    450                 455                 460                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
465                 470                 475                 480 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                485                 490                 495     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            500                 505                 510         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        515                 520                 525             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    530                 535                 540                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
545                 550                 555                 560 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                565                 570                 575     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            580                 585                 590         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        595                 600                 605             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    610                 615                 620                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
625                 630                 635                 640 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                645                 650                 655     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            660                 665                 670         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        675                 680                 685             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    690                 695                 700                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
705                 710                 715                 720 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                725                 730                 735     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            740                 745                 750         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        755                 760                 765             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    770                 775                 780                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
785                 790                 795                 800 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                805                 810                 815     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            820                 825 


<210> 7
<211> 258
<212> PRT
<213> Homo sapiens

<400> 7
Met Leu Pro Leu Cys Leu Val Ala Ala Leu Leu Leu Ala Ala Gly Pro 
1               5                   10                  15      


Gly Pro Ser Leu Gly Asp Glu Ala Ile His Cys Pro Pro Cys Ser Glu 
            20                  25                  30          


Glu Lys Leu Ala Arg Cys Arg Pro Pro Val Gly Cys Glu Glu Leu Val 
        35                  40                  45              


Arg Glu Pro Gly Cys Gly Cys Cys Ala Thr Cys Ala Leu Gly Leu Gly 
    50                  55                  60                  


Met Pro Cys Gly Val Tyr Thr Pro Arg Cys Gly Ser Gly Leu Arg Cys 
65                  70                  75                  80  


Tyr Pro Pro Arg Gly Val Glu Lys Pro Leu His Thr Leu Met His Gly 
                85                  90                  95      


Gln Gly Val Cys Met Glu Leu Ala Glu Ile Glu Ala Ile Gln Glu Ser 
            100                 105                 110         


Leu Gln Pro Ser Asp Lys Asp Glu Gly Asp His Pro Asn Asn Ser Phe 
        115                 120                 125             


Ser Pro Cys Ser Ala His Asp Arg Arg Cys Leu Gln Lys His Phe Ala 
    130                 135                 140                 


Lys Ile Arg Asp Arg Ser Thr Ser Gly Gly Lys Met Lys Val Asn Gly 
145                 150                 155                 160 


Ala Pro Arg Glu Asp Ala Arg Pro Val Pro Gln Gly Ser Cys Gln Ser 
                165                 170                 175     


Glu Leu His Arg Ala Leu Glu Arg Leu Ala Ala Ser Gln Ser Arg Thr 
            180                 185                 190         


His Glu Asp Leu Tyr Ile Ile Pro Ile Pro Asn Cys Asp Arg Asn Gly 
        195                 200                 205             


Asn Phe His Pro Lys Gln Cys His Pro Ala Leu Asp Gly Gln Arg Gly 
    210                 215                 220                 


Lys Cys Trp Cys Val Asp Arg Lys Thr Gly Val Lys Leu Pro Gly Gly 
225                 230                 235                 240 


Leu Glu Pro Lys Gly Glu Leu Asp Cys His Gln Leu Ala Asp Ser Phe 
                245                 250                 255     


Arg Glu 
        


<210> 8
<211> 272
<212> PRT
<213> Homo sapiens

<400> 8
Met Val Leu Leu Thr Ala Val Leu Leu Leu Leu Ala Ala Tyr Ala Gly 
1               5                   10                  15      


Pro Ala Gln Ser Leu Gly Ser Phe Val His Cys Glu Pro Cys Asp Glu 
            20                  25                  30          


Lys Ala Leu Ser Met Cys Pro Pro Ser Pro Leu Gly Cys Glu Leu Val 
        35                  40                  45              


Lys Glu Pro Gly Cys Gly Cys Cys Met Thr Cys Ala Leu Ala Glu Gly 
    50                  55                  60                  


Gln Ser Cys Gly Val Tyr Thr Glu Arg Cys Ala Gln Gly Leu Arg Cys 
65                  70                  75                  80  


Leu Pro Arg Gln Asp Glu Glu Lys Pro Leu His Ala Leu Leu His Gly 
                85                  90                  95      


Arg Gly Val Cys Leu Asn Glu Lys Ser Tyr Arg Glu Gln Val Lys Ile 
            100                 105                 110         


Glu Arg Asp Ser Arg Glu His Glu Glu Pro Thr Thr Ser Glu Met Ala 
        115                 120                 125             


Glu Glu Thr Tyr Ser Pro Lys Ile Phe Arg Pro Lys His Thr Arg Ile 
    130                 135                 140                 


Ser Glu Leu Lys Ala Glu Ala Val Lys Lys Asp Arg Arg Lys Lys Leu 
145                 150                 155                 160 


Thr Gln Ser Lys Phe Val Gly Gly Ala Glu Asn Thr Ala His Pro Arg 
                165                 170                 175     


Ile Ile Ser Ala Pro Glu Met Arg Gln Glu Ser Glu Gln Gly Pro Cys 
            180                 185                 190         


Arg Arg His Met Glu Ala Ser Leu Gln Glu Leu Lys Ala Ser Pro Arg 
        195                 200                 205             


Met Val Pro Arg Ala Val Tyr Leu Pro Asn Cys Asp Arg Lys Gly Phe 
    210                 215                 220                 


Tyr Lys Arg Lys Gln Cys Lys Pro Ser Arg Gly Arg Lys Arg Gly Ile 
225                 230                 235                 240 


Cys Trp Cys Val Asp Lys Tyr Gly Met Lys Leu Pro Gly Met Glu Tyr 
                245                 250                 255     


Val Asp Gly Asp Phe Gln Cys His Thr Phe Asp Ser Ser Asn Val Glu 
            260                 265                 270         


<210> 9
<211> 189
<212> PRT
<213> Homo sapiens

<400> 9
Met Leu Gly Ser Arg Ala Val Met Leu Leu Leu Leu Leu Pro Trp Thr 
1               5                   10                  15      


Ala Gln Gly Arg Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln 
            20                  25                  30          


Cys Gln Gln Leu Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His 
        35                  40                  45              


Pro Leu Val Gly His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr 
    50                  55                  60                  


Thr Asn Asp Val Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln 
65                  70                  75                  80  


Gly Leu Arg Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile His Gln Gly 
                85                  90                  95      


Leu Ile Phe Tyr Glu Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu 
            100                 105                 110         


Pro Ser Leu Leu Pro Asp Ser Pro Val Gly Gln Leu His Ala Ser Leu 
        115                 120                 125             


Leu Gly Leu Ser Gln Leu Leu Gln Pro Glu Gly His His Trp Glu Thr 
    130                 135                 140                 


Gln Gln Ile Pro Ser Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu 
145                 150                 155                 160 


Leu Arg Phe Lys Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala 
                165                 170                 175     


Ala Arg Val Phe Ala His Gly Ala Ala Thr Leu Ser Pro 
            180                 185                 


<210> 10
<211> 200
<212> PRT
<213> Homo sapiens

<400> 10
Met Lys Leu Asp Met Thr Gly Asp Cys Thr Pro Val Leu Val Leu Met 
1               5                   10                  15      


Ala Ala Val Leu Thr Val Thr Gly Ala Val Pro Val Ala Arg Leu His 
            20                  25                  30          


Gly Ala Leu Pro Asp Ala Arg Gly Cys His Ile Ala Gln Phe Lys Ser 
        35                  40                  45              


Leu Ser Pro Gln Glu Leu Gln Ala Phe Lys Arg Ala Lys Asp Ala Leu 
    50                  55                  60                  


Glu Glu Ser Leu Leu Leu Lys Asp Cys Arg Cys His Ser Arg Leu Phe 
65                  70                  75                  80  


Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln Val Arg Glu Arg Pro Met 
                85                  90                  95      


Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Thr 
            100                 105                 110         


Ala Asp Thr Asp Pro Ala Leu Val Asp Val Leu Asp Gln Pro Leu His 
        115                 120                 125             


Thr Leu His His Ile Leu Ser Gln Phe Arg Ala Cys Ile Gln Pro Gln 
    130                 135                 140                 


Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg Leu His His Trp Leu Tyr 
145                 150                 155                 160 


Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Pro Gly Cys Leu Glu Ala 
                165                 170                 175     


Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Asn Cys 
            180                 185                 190         


Val Ala Ser Gly Asp Leu Cys Val 
        195                 200 


<210> 11
<211> 270
<212> PRT
<213> Homo sapiens

<400> 11
Met Lys Pro Lys Met Lys Tyr Ser Thr Asn Lys Ile Ser Thr Ala Lys 
1               5                   10                  15      


Trp Lys Asn Thr Ala Ser Lys Ala Leu Cys Phe Lys Leu Gly Lys Ser 
            20                  25                  30          


Gln Gln Lys Ala Lys Glu Val Cys Pro Met Tyr Phe Met Lys Leu Arg 
        35                  40                  45              


Ser Gly Leu Met Ile Lys Lys Glu Ala Cys Tyr Phe Arg Arg Glu Thr 
    50                  55                  60                  


Thr Lys Arg Pro Ser Leu Lys Thr Gly Arg Lys His Lys Arg His Leu 
65                  70                  75                  80  


Val Leu Ala Ala Cys Gln Gln Gln Ser Thr Val Glu Cys Phe Ala Phe 
                85                  90                  95      


Gly Ile Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp Ser Ser 
            100                 105                 110         


Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr 
        115                 120                 125             


Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu 
    130                 135                 140                 


Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val Leu 
145                 150                 155                 160 


Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp Gly 
                165                 170                 175     


Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp Phe 
            180                 185                 190         


Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys Cys 
        195                 200                 205             


Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met His 
    210                 215                 220                 


Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe Ile 
225                 230                 235                 240 


Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser Glu 
                245                 250                 255     


Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
            260                 265                 270 


<210> 12
<211> 141
<212> PRT
<213> Homo sapiens

<400> 12
Met Glu Met Leu Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Ala Trp Ala Ser Arg Glu Pro Leu Arg Pro Trp Cys His Pro Ile 
            20                  25                  30          


Asn Ala Ile Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Met Arg Val 
    50                  55                  60                  


Leu Gln Ala Val Leu Pro Pro Leu Pro Gln Val Val Cys Thr Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asp Pro Val Val Ser Phe Pro Val Ala Leu Ser Cys Arg Cys Gly Pro 
            100                 105                 110         


Cys Arg Arg Ser Thr Ser Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp His Pro Gln Leu Ser Gly Leu Leu Phe Leu 
    130                 135                 140     


<210> 13
<211> 469
<212> PRT
<213> Homo sapiens

<400> 13
Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val 
1               5                   10                  15      


Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly 
        35                  40                  45              


Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu 
    50                  55                  60                  


Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp 
65                  70                  75                  80  


Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala 
        115                 120                 125             


Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly 
            180                 185                 190         


Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg 
        195                 200                 205             


Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr 
225                 230                 235                 240 


Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile 
                245                 250                 255     


Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro 
            260                 265                 270         


Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr 
        275                 280                 285             


Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg 
    290                 295                 300                 


Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe 
305                 310                 315                 320 


Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp 
                325                 330                 335     


Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln 
            340                 345                 350         


Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe 
        355                 360                 365             


Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu 
    370                 375                 380                 


Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr 
385                 390                 395                 400 


Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala 
                405                 410                 415     


His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys 
            420                 425                 430         


Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp 
        435                 440                 445             


Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe 
    450                 455                 460                 


Asn Cys Arg Lys Asn 
465                 


<210> 14
<211> 858
<212> PRT
<213> Homo sapiens

<400> 14
Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Thr Leu Asp Gly His 
        355                 360                 365             


Met Val Val Arg Ser His Ala Arg Val Ser Ser Leu Thr Leu Lys Ser 
    370                 375                 380                 


Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr 
385                 390                 395                 400 


Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro 
                405                 410                 415     


Lys Leu Gln Gly Pro Val Ala Val Tyr Thr Trp Glu Gly Asn Gln Val 
            420                 425                 430         


Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp 
        435                 440                 445             


Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys 
    450                 455                 460                 


Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser 
465                 470                 475                 480 


Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly 
                485                 490                 495     


Gln Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser 
            500                 505                 510         


Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln 
        515                 520                 525             


Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys 
    530                 535                 540                 


Ala Glu Trp Arg Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr 
545                 550                 555                 560 


Asp Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu 
                565                 570                 575     


Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys 
            580                 585                 590         


Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val 
        595                 600                 605             


Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp 
    610                 615                 620                 


Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser 
625                 630                 635                 640 


Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp 
                645                 650                 655     


Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys 
            660                 665                 670         


Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn 
        675                 680                 685             


Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala 
    690                 695                 700                 


Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser 
705                 710                 715                 720 


Thr Gly Ala Ile Val Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu 
                725                 730                 735     


Val Val Val Asp Ile Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe 
            740                 745                 750         


Met Cys Ile Ala Val Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys 
        755                 760                 765             


Gly Lys Asp Met Glu Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser 
    770                 775                 780                 


Lys Glu Pro Ile Val Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn 
785                 790                 795                 800 


His Asp Gly Gly Lys His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr 
                805                 810                 815     


Glu Pro Glu Lys Gly Pro Val Glu Ala Lys Pro Glu Cys Gln Glu Thr 
            820                 825                 830         


Glu Thr Lys Pro Ala Pro Ala Glu Val Lys Thr Val Pro Asn Asp Ala 
        835                 840                 845             


Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
    850                 855             


<210> 15
<211> 36
<212> PRT
<213> Homo sapiens

<400> 15
His Ser Pro Pro Pro Pro Ala Ser Ala Ser Ser Ser Thr Pro Val Pro 
1               5                   10                  15      


Leu Ser Pro Pro Asp Thr Thr Trp Pro Leu Pro Ala Leu Ala Thr Thr 
            20                  25                  30          


Glu Pro Ala Lys 
        35      


<210> 16
<211> 25
<212> PRT
<213> Homo sapiens

<400> 16
Asn Gly Ser Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly Ile 
1               5                   10                  15      


Leu Ile Val Ile Phe Val Leu Leu Leu 
            20                  25  


<210> 17
<211> 25
<212> PRT
<213> Homo sapiens

<400> 17
Thr Leu Gly Gly Asn Ser Ala Ser Tyr Thr Phe Val Ser Leu Leu Phe 
1               5                   10                  15      


Ser Ala Val Thr Leu Leu Leu Leu Cys 
            20                  25  


<210> 18
<211> 25
<212> PRT
<213> Homo sapiens

<400> 18
Asn Gly Ser Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly Ile 
1               5                   10                  15      


Leu Ile Val Ile Phe Val Leu Leu Leu 
            20                  25  


<210> 19
<211> 25
<212> PRT
<213> Homo sapiens

<400> 19
Thr Leu Gly Gly Asn Ser Ala Ser Tyr Thr Phe Val Ser Leu Leu Phe 
1               5                   10                  15      


Ser Ala Val Thr Leu Leu Leu Leu Cys 
            20                  25  


<210> 20
<211> 10
<212> PRT
<213> Homo sapiens

<400> 20
Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly 
1               5                   10  


<210> 21
<211> 57
<212> PRT
<213> Homo sapiens

<400> 21
His Ser Pro Pro Pro Pro Ala Ser Ala Ser Ser Ser Thr Pro Val Pro 
1               5                   10                  15      


Leu Ser Pro Pro Asp Thr Thr Trp Pro Leu Pro Ala Leu Ala Thr Thr 
            20                  25                  30          


Glu Pro Ala Lys Asn Ile Ala Gln Asn His Cys Cys Asn Met Phe Gln 
        35                  40                  45              


Ala Gly Leu His Asn Ala Leu Met Lys 
    50                  55          


<210> 22
<211> 418
<212> PRT
<213> Homo sapiens

<400> 22
Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser Pro Asp 
            20                  25                  30          


Pro Asp Ser Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe Phe Lys 
        35                  40                  45              


Val Pro Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp 
    50                  55                  60                  


Leu Tyr Arg Val Arg Ser Ser Met Ser Pro Thr Thr Asn Val Leu Leu 
65                  70                  75                  80  


Ser Pro Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala 
                85                  90                  95      


Glu Gln Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu 
            100                 105                 110         


Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr 
        115                 120                 125             


Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val Phe 
    130                 135                 140                 


Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu Glu Lys 
145                 150                 155                 160 


Ser Tyr Gly Thr Arg Pro Arg Val Leu Thr Gly Asn Pro Arg Leu Asp 
                165                 170                 175     


Leu Gln Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Leu 
            180                 185                 190         


Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu 
        195                 200                 205             


Gly Val Ala His Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg 
    210                 215                 220                 


Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg 
225                 230                 235                 240 


Val Pro Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp 
                245                 250                 255     


Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Met 
            260                 265                 270         


Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu Thr Leu 
        275                 280                 285             


Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu 
    290                 295                 300                 


Leu Lys Thr Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys Leu Ser 
305                 310                 315                 320 


Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser 
                325                 330                 335     


Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys 
            340                 345                 350         


Leu Thr Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly 
        355                 360                 365             


Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe 
    370                 375                 380                 


Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp 
385                 390                 395                 400 


Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg 
                405                 410                 415     


Gly Pro 
        


<210> 23
<211> 211
<212> PRT
<213> Homo sapiens

<400> 23
Met Arg Thr Leu Ala Cys Leu Leu Leu Leu Gly Cys Gly Tyr Leu Ala 
1               5                   10                  15      


His Val Leu Ala Glu Glu Ala Glu Ile Pro Arg Glu Val Ile Glu Arg 
            20                  25                  30          


Leu Ala Arg Ser Gln Ile His Ser Ile Arg Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


Glu Ile Asp Ser Val Gly Ser Glu Asp Ser Leu Asp Thr Ser Leu Arg 
    50                  55                  60                  


Ala His Gly Val His Ala Thr Lys His Val Pro Glu Lys Arg Pro Leu 
65                  70                  75                  80  


Pro Ile Arg Arg Lys Arg Ser Ile Glu Glu Ala Val Pro Ala Val Cys 
                85                  90                  95      


Lys Thr Arg Thr Val Ile Tyr Glu Ile Pro Arg Ser Gln Val Asp Pro 
            100                 105                 110         


Thr Ser Ala Asn Phe Leu Ile Trp Pro Pro Cys Val Glu Val Lys Arg 
        115                 120                 125             


Cys Thr Gly Cys Cys Asn Thr Ser Ser Val Lys Cys Gln Pro Ser Arg 
    130                 135                 140                 


Val His His Arg Ser Val Lys Val Ala Lys Val Glu Tyr Val Arg Lys 
145                 150                 155                 160 


Lys Pro Lys Leu Lys Glu Val Gln Val Arg Leu Glu Glu His Leu Glu 
                165                 170                 175     


Cys Ala Cys Ala Thr Thr Ser Leu Asn Pro Asp Tyr Arg Glu Glu Asp 
            180                 185                 190         


Thr Gly Arg Pro Arg Glu Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu 
        195                 200                 205             


Lys Pro Thr 
    210     


<210> 24
<211> 1356
<212> PRT
<213> Homo sapiens

<400> 24
Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


<210> 25
<211> 1298
<212> PRT
<213> Homo sapiens

<400> 25
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly 
1               5                   10                  15      


Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu 
            20                  25                  30          


Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser 
        35                  40                  45              


Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala 
    50                  55                  60                  


Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val 
65                  70                  75                  80  


Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu 
                85                  90                  95      


Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr 
            100                 105                 110         


Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser 
        115                 120                 125             


Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp 
    130                 135                 140                 


Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val 
145                 150                 155                 160 


Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu 
                165                 170                 175     


Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu 
            180                 185                 190         


Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr 
        195                 200                 205             


Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile 
    210                 215                 220                 


Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu 
225                 230                 235                 240 


Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala 
                245                 250                 255     


Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln 
            260                 265                 270         


Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His 
        275                 280                 285             


Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp 
    290                 295                 300                 


Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg 
305                 310                 315                 320 


Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu 
                325                 330                 335     


Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val 
            340                 345                 350         


Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp 
        355                 360                 365             


Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu 
    370                 375                 380                 


Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala 
385                 390                 395                 400 


Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu 
                405                 410                 415     


Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro 
            420                 425                 430         


Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr 
        435                 440                 445             


Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr 
    450                 455                 460                 


Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln 
465                 470                 475                 480 


Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp 
                485                 490                 495     


Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu 
            500                 505                 510         


Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val 
        515                 520                 525             


Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu 
    530                 535                 540                 


Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile 
545                 550                 555                 560 


Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu 
                565                 570                 575     


Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg 
            580                 585                 590         


Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu 
        595                 600                 605             


Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu 
    610                 615                 620                 


Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile 
625                 630                 635                 640 


Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln 
                645                 650                 655     


Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val 
            660                 665                 670         


Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu 
        675                 680                 685             


Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala 
    690                 695                 700                 


His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu 
705                 710                 715                 720 


Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln 
                725                 730                 735     


Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn 
            740                 745                 750         


Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser 
        755                 760                 765             


Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val 
    770                 775                 780                 


Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met 
785                 790                 795                 800 


Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile 
                805                 810                 815     


Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser 
            820                 825                 830         


Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly 
        835                 840                 845             


Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala 
    850                 855                 860                 


Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met 
865                 870                 875                 880 


Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu 
                885                 890                 895     


Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu 
            900                 905                 910         


Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu 
        915                 920                 925             


Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp 
    930                 935                 940                 


Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe 
945                 950                 955                 960 


Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser 
                965                 970                 975     


Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala 
            980                 985                 990         


Arg Arg Ala Ser Pro Asp Gln Glu  Ala Glu Asp Leu Trp  Leu Ser Pro 
        995                 1000                 1005             


Leu Thr  Met Glu Asp Leu Val  Cys Tyr Ser Phe Gln  Val Ala Arg 
    1010                 1015                 1020             


Gly Met  Glu Phe Leu Ala Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1025                 1030                 1035             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Ser Asp Val  Val Lys Ile 
    1040                 1045                 1050             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asp  Pro Asp Tyr 
    1055                 1060                 1065             


Val Arg  Lys Gly Ser Ala Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1070                 1075                 1080             


Glu Ser  Ile Phe Asp Lys Val  Tyr Thr Thr Gln Ser  Asp Val Trp 
    1085                 1090                 1095             


Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Ala Ser 
    1100                 1105                 1110             


Pro Tyr  Pro Gly Val Gln Ile  Asn Glu Glu Phe Cys  Gln Arg Leu 
    1115                 1120                 1125             


Arg Asp  Gly Thr Arg Met Arg  Ala Pro Glu Leu Ala  Thr Pro Ala 
    1130                 1135                 1140             


Ile Arg  Arg Ile Met Leu Asn  Cys Trp Ser Gly Asp  Pro Lys Ala 
    1145                 1150                 1155             


Arg Pro  Ala Phe Ser Glu Leu  Val Glu Ile Leu Gly  Asp Leu Leu 
    1160                 1165                 1170             


Gln Gly  Arg Gly Leu Gln Glu  Glu Glu Glu Val Cys  Met Ala Pro 
    1175                 1180                 1185             


Arg Ser  Ser Gln Ser Ser Glu  Glu Gly Ser Phe Ser  Gln Val Ser 
    1190                 1195                 1200             


Thr Met  Ala Leu His Ile Ala  Gln Ala Asp Ala Glu  Asp Ser Pro 
    1205                 1210                 1215             


Pro Ser  Leu Gln Arg His Ser  Leu Ala Ala Arg Tyr  Tyr Asn Trp 
    1220                 1225                 1230             


Val Ser  Phe Pro Gly Cys Leu  Ala Arg Gly Ala Glu  Thr Arg Gly 
    1235                 1240                 1245             


Ser Ser  Arg Met Lys Thr Phe  Glu Glu Phe Pro Met  Thr Pro Thr 
    1250                 1255                 1260             


Thr Tyr  Lys Gly Ser Val Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1265                 1270                 1275             


Leu Ala  Ser Glu Glu Phe Glu  Gln Ile Glu Ser Arg  His Arg Gln 
    1280                 1285                 1290             


Glu Ser  Gly Phe Arg 
    1295             


<210> 26
<211> 595
<212> PRT
<213> Homo sapiens

<400> 26
Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 
1               5                   10                  15      


Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 
            20                  25                  30          


Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 
        35                  40                  45              


Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 
    50                  55                  60                  


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
                85                  90                  95      


Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 
            100                 105                 110         


Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 
        115                 120                 125             


Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 
    130                 135                 140                 


Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 
145                 150                 155                 160 


Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 
                165                 170                 175     


Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 
            180                 185                 190         


Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 
        195                 200                 205             


Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 
    210                 215                 220                 


Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 
225                 230                 235                 240 


Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 
                245                 250                 255     


Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            260                 265                 270         


Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 
        275                 280                 285             


Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro 
    290                 295                 300                 


Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
                325                 330                 335     


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
            340                 345                 350         


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
        355                 360                 365             


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
    370                 375                 380                 


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
385                 390                 395                 400 


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
                405                 410                 415     


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
            420                 425                 430         


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
        435                 440                 445             


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
    450                 455                 460                 


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
465                 470                 475                 480 


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
                485                 490                 495     


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
            500                 505                 510         


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
        515                 520                 525             


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
    530                 535                 540                 


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
545                 550                 555                 560 


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
                565                 570                 575     


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
            580                 585                 590         


Ser Gly Lys 
        595 


<210> 27
<211> 609
<212> PRT
<213> Homo sapiens

<400> 27
Met Lys Trp Val Glu Ser Ile Phe Leu Ile Phe Leu Leu Asn Phe Thr 
1               5                   10                  15      


Glu Ser Arg Thr Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu 
            20                  25                  30          


Asp Ser Tyr Gln Cys Thr Ala Glu Ile Ser Leu Ala Asp Leu Ala Thr 
        35                  40                  45              


Ile Phe Phe Ala Gln Phe Val Gln Glu Ala Thr Tyr Lys Glu Val Ser 
    50                  55                  60                  


Lys Met Val Lys Asp Ala Leu Thr Ala Ile Glu Lys Pro Thr Gly Asp 
65                  70                  75                  80  


Glu Gln Ser Ser Gly Cys Leu Glu Asn Gln Leu Pro Ala Phe Leu Glu 
                85                  90                  95      


Glu Leu Cys His Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp 
            100                 105                 110         


Cys Cys Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His 
        115                 120                 125             


Lys Lys Pro Thr Pro Ala Ser Ile Pro Leu Phe Gln Val Pro Glu Pro 
    130                 135                 140                 


Val Thr Ser Cys Glu Ala Tyr Glu Glu Asp Arg Glu Thr Phe Met Asn 
145                 150                 155                 160 


Lys Phe Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr Ala Pro 
                165                 170                 175     


Thr Ile Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys 
            180                 185                 190         


Cys Lys Ala Glu Asn Ala Val Glu Cys Phe Gln Thr Lys Ala Ala Thr 
        195                 200                 205             


Val Thr Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys 
    210                 215                 220                 


Ala Val Met Lys Asn Phe Gly Thr Arg Thr Phe Gln Ala Ile Thr Val 
225                 230                 235                 240 


Thr Lys Leu Ser Gln Lys Phe Thr Lys Val Asn Phe Thr Glu Ile Gln 
                245                 250                 255     


Lys Leu Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly 
            260                 265                 270         


Asp Val Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile 
        275                 280                 285             


Cys Ser Gln Gln Asp Thr Leu Ser Asn Lys Ile Thr Glu Cys Cys Lys 
    290                 295                 300                 


Leu Thr Thr Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu Asn Asp 
305                 310                 315                 320 


Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu Gly Asp 
                325                 330                 335     


Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala 
            340                 345                 350         


Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser 
        355                 360                 365             


Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys 
    370                 375                 380                 


Phe Gln Thr Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu Glu Glu 
385                 390                 395                 400 


Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg Ser Cys 
                405                 410                 415     


Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu 
            420                 425                 430         


Val Ala Tyr Thr Lys Lys Ala Pro Gln Leu Thr Ser Ser Glu Leu Met 
        435                 440                 445             


Ala Ile Thr Arg Lys Met Ala Ala Thr Ala Ala Thr Cys Cys Gln Leu 
    450                 455                 460                 


Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile 
465                 470                 475                 480 


Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro Gly 
                485                 490                 495     


Val Gly Gln Cys Cys Thr Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ser Leu Val Val Asp Glu Thr Tyr Val Pro Pro Ala Phe Ser Asp 
        515                 520                 525             


Asp Lys Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala 
    530                 535                 540                 


Leu Gln Thr Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys Gln Lys 
545                 550                 555                 560 


Pro Gln Ile Thr Glu Glu Gln Leu Glu Ala Val Ile Ala Asp Phe Ser 
                565                 570                 575     


Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Gln Lys Leu Ile Ser Lys Thr Arg Ala Ala Leu Gly 
        595                 600                 605             


Val 
    


<210> 28
<211> 415
<212> PRT
<213> Homo sapiens

<400> 28
Met Ser Pro Phe Leu Tyr Leu Val Leu Leu Val Leu Gly Leu His Ala 
1               5                   10                  15      


Thr Ile His Cys Ala Ser Pro Glu Gly Lys Val Thr Ala Cys His Ser 
            20                  25                  30          


Ser Gln Pro Asn Ala Thr Leu Tyr Lys Met Ser Ser Ile Asn Ala Asp 
        35                  40                  45              


Phe Ala Phe Asn Leu Tyr Arg Arg Phe Thr Val Glu Thr Pro Asp Lys 
    50                  55                  60                  


Asn Ile Phe Phe Ser Pro Val Ser Ile Ser Ala Ala Leu Val Met Leu 
65                  70                  75                  80  


Ser Phe Gly Ala Cys Cys Ser Thr Gln Thr Glu Ile Val Glu Thr Leu 
                85                  90                  95      


Gly Phe Asn Leu Thr Asp Thr Pro Met Val Glu Ile Gln His Gly Phe 
            100                 105                 110         


Gln His Leu Ile Cys Ser Leu Asn Phe Pro Lys Lys Glu Leu Glu Leu 
        115                 120                 125             


Gln Ile Gly Asn Ala Leu Phe Ile Gly Lys His Leu Lys Pro Leu Ala 
    130                 135                 140                 


Lys Phe Leu Asn Asp Val Lys Thr Leu Tyr Glu Thr Glu Val Phe Ser 
145                 150                 155                 160 


Thr Asp Phe Ser Asn Ile Ser Ala Ala Lys Gln Glu Ile Asn Ser His 
                165                 170                 175     


Val Glu Met Gln Thr Lys Gly Lys Val Val Gly Leu Ile Gln Asp Leu 
            180                 185                 190         


Lys Pro Asn Thr Ile Met Val Leu Val Asn Tyr Ile His Phe Lys Ala 
        195                 200                 205             


Gln Trp Ala Asn Pro Phe Asp Pro Ser Lys Thr Glu Asp Ser Ser Ser 
    210                 215                 220                 


Phe Leu Ile Asp Lys Thr Thr Thr Val Gln Val Pro Met Met His Gln 
225                 230                 235                 240 


Met Glu Gln Tyr Tyr His Leu Val Asp Met Glu Leu Asn Cys Thr Val 
                245                 250                 255     


Leu Gln Met Asp Tyr Ser Lys Asn Ala Leu Ala Leu Phe Val Leu Pro 
            260                 265                 270         


Lys Glu Gly Gln Met Glu Ser Val Glu Ala Ala Met Ser Ser Lys Thr 
        275                 280                 285             


Leu Lys Lys Trp Asn Arg Leu Leu Gln Lys Gly Trp Val Asp Leu Phe 
    290                 295                 300                 


Val Pro Lys Phe Ser Ile Ser Ala Thr Tyr Asp Leu Gly Ala Thr Leu 
305                 310                 315                 320 


Leu Lys Met Gly Ile Gln His Ala Tyr Ser Glu Asn Ala Asp Phe Ser 
                325                 330                 335     


Gly Leu Thr Glu Asp Asn Gly Leu Lys Leu Ser Asn Ala Ala His Lys 
            340                 345                 350         


Ala Val Leu His Ile Gly Glu Lys Gly Thr Glu Ala Ala Ala Val Pro 
        355                 360                 365             


Glu Val Glu Leu Ser Asp Gln Pro Glu Asn Thr Phe Leu His Pro Ile 
    370                 375                 380                 


Ile Gln Ile Asp Arg Ser Phe Met Leu Leu Ile Leu Glu Arg Ser Thr 
385                 390                 395                 400 


Arg Ser Ile Leu Phe Leu Gly Lys Val Val Asn Pro Thr Glu Ala 
                405                 410                 415 


<210> 29
<211> 261
<212> PRT
<213> Homo sapiens

<400> 29
Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro 
225                 230                 235                 240 


Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Val Ala Asn Pro 
            260     


<210> 30
<211> 4548
<212> PRT
<213> Homo sapiens

<400> 30
Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Ala Ala Pro Glu Gln Ser His Val Val Gln Asp Cys Tyr His Gly Asp 
            20                  25                  30          


Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr 
        35                  40                  45              


Cys Gln Ala Trp Ser Ser Met Thr Pro His Gln His Asn Arg Thr Thr 
    50                  55                  60                  


Glu Asn Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro 
65                  70                  75                  80  


Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg 
                85                  90                  95      


Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala 
            100                 105                 110         


Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser 
        115                 120                 125             


Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His 
    130                 135                 140                 


Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly 
145                 150                 155                 160 


Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg 
                165                 170                 175     


Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg 
            180                 185                 190         


Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly 
        195                 200                 205             


Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly 
    210                 215                 220                 


Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala 
225                 230                 235                 240 


Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys 
                245                 250                 255     


Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val 
            260                 265                 270         


Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His 
        275                 280                 285             


Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr 
    290                 295                 300                 


Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp 
305                 310                 315                 320 


Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala 
                325                 330                 335     


Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu 
            340                 345                 350         


Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln 
        355                 360                 365             


Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr 
    370                 375                 380                 


Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His 
385                 390                 395                 400 


Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met 
                405                 410                 415     


Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr 
            420                 425                 430         


Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser 
        435                 440                 445             


Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro 
    450                 455                 460                 


Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly 
465                 470                 475                 480 


Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr 
                485                 490                 495     


Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr 
            500                 505                 510         


Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu 
        515                 520                 525             


Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys 
    530                 535                 540                 


Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln 
545                 550                 555                 560 


Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro 
                565                 570                 575     


Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg 
            580                 585                 590         


Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly 
        595                 600                 605             


Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser 
    610                 615                 620                 


Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala 
625                 630                 635                 640 


Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro 
                645                 650                 655     


Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu 
            660                 665                 670         


Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val 
        675                 680                 685             


Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu 
    690                 695                 700                 


Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr 
705                 710                 715                 720 


Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp 
                725                 730                 735     


Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro 
            740                 745                 750         


Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala 
        755                 760                 765             


Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys 
    770                 775                 780                 


Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro 
785                 790                 795                 800 


Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro 
                805                 810                 815     


Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln 
            820                 825                 830         


Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln 
        835                 840                 845             


Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr 
    850                 855                 860                 


Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala 
865                 870                 875                 880 


Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu 
                885                 890                 895     


Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala 
            900                 905                 910         


Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln 
        915                 920                 925             


Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn 
    930                 935                 940                 


Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr 
945                 950                 955                 960 


Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro 
                965                 970                 975     


Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro 
            980                 985                 990         


Asp Ala Val Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 
        995                 1000                 1005             


Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 
    1010                 1015                 1020             


Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 
    1025                 1030                 1035             


Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 
    1040                 1045                 1050             


Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    1055                 1060                 1065             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    1070                 1075                 1080             


His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 
    1085                 1090                 1095             


Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Ala Val Ala  Ala Pro Tyr 
    1100                 1105                 1110             


Cys Tyr  Thr Arg Asp Pro Gly  Val Arg Trp Glu Tyr  Cys Asn Leu 
    1115                 1120                 1125             


Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 
    1130                 1135                 1140             


Val Thr  Pro Val Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 
    1145                 1150                 1155             


Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 
    1160                 1165                 1170             


Gln Ser  Tyr Arg Gly Thr Tyr  Ser Thr Thr Val Thr  Gly Arg Thr 
    1175                 1180                 1185             


Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 
    1190                 1195                 1200             


Pro Glu  Tyr Tyr Pro Asn Ala  Gly Leu Ile Met Asn  Tyr Cys Arg 
    1205                 1210                 1215             


Asn Pro  Asp Ala Val Ala Ala  Pro Tyr Cys Tyr Thr  Arg Asp Pro 
    1220                 1225                 1230             


Gly Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Ser Asp Ala 
    1235                 1240                 1245             


Glu Gly  Thr Ala Val Ala Pro  Pro Thr Val Thr Pro  Val Pro Ser 
    1250                 1255                 1260             


Leu Glu  Ala Pro Ser Glu Gln  Ala Pro Thr Glu Gln  Arg Pro Gly 
    1265                 1270                 1275             


Val Gln  Glu Cys Tyr His Gly  Asn Gly Gln Ser Tyr  Arg Gly Thr 
    1280                 1285                 1290             


Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 
    1295                 1300                 1305             


Met Thr  Pro His Ser His Ser  Arg Thr Pro Glu Tyr  Tyr Pro Asn 
    1310                 1315                 1320             


Ala Gly  Leu Ile Met Asn Tyr  Cys Arg Asn Pro Asp  Ala Val Ala 
    1325                 1330                 1335             


Ala Pro  Tyr Cys Tyr Thr Arg  Asp Pro Gly Val Arg  Trp Glu Tyr 
    1340                 1345                 1350             


Cys Asn  Leu Thr Gln Cys Ser  Asp Ala Glu Gly Thr  Ala Val Ala 
    1355                 1360                 1365             


Pro Pro  Thr Val Thr Pro Val  Pro Ser Leu Glu Ala  Pro Ser Glu 
    1370                 1375                 1380             


Gln Ala  Pro Thr Glu Gln Arg  Pro Gly Val Gln Glu  Cys Tyr His 
    1385                 1390                 1395             


Gly Asn  Gly Gln Ser Tyr Arg  Gly Thr Tyr Ser Thr  Thr Val Thr 
    1400                 1405                 1410             


Gly Arg  Thr Cys Gln Ala Trp  Ser Ser Met Thr Pro  His Ser His 
    1415                 1420                 1425             


Ser Arg  Thr Pro Glu Tyr Tyr  Pro Asn Ala Gly Leu  Ile Met Asn 
    1430                 1435                 1440             


Tyr Cys  Arg Asn Pro Asp Ala  Val Ala Ala Pro Tyr  Cys Tyr Thr 
    1445                 1450                 1455             


Arg Asp  Pro Gly Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 
    1460                 1465                 1470             


Ser Asp  Ala Glu Gly Thr Ala  Val Ala Pro Pro Thr  Val Thr Pro 
    1475                 1480                 1485             


Val Pro  Ser Leu Glu Ala Pro  Ser Glu Gln Ala Pro  Thr Glu Gln 
    1490                 1495                 1500             


Arg Pro  Gly Val Gln Glu Cys  Tyr His Gly Asn Gly  Gln Ser Tyr 
    1505                 1510                 1515             


Arg Gly  Thr Tyr Ser Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ala 
    1520                 1525                 1530             


Trp Ser  Ser Met Thr Pro His  Ser His Ser Arg Thr  Pro Glu Tyr 
    1535                 1540                 1545             


Tyr Pro  Asn Ala Gly Leu Ile  Met Asn Tyr Cys Arg  Asn Pro Asp 
    1550                 1555                 1560             


Ala Val  Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 
    1565                 1570                 1575             


Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 
    1580                 1585                 1590             


Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 
    1595                 1600                 1605             


Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 
    1610                 1615                 1620             


Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    1625                 1630                 1635             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    1640                 1645                 1650             


His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 
    1655                 1660                 1665             


Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Ala Val Ala  Ala Pro Tyr 
    1670                 1675                 1680             


Cys Tyr  Thr Arg Asp Pro Gly  Val Arg Trp Glu Tyr  Cys Asn Leu 
    1685                 1690                 1695             


Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 
    1700                 1705                 1710             


Val Thr  Pro Val Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 
    1715                 1720                 1725             


Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 
    1730                 1735                 1740             


Gln Ser  Tyr Arg Gly Thr Tyr  Ser Thr Thr Val Thr  Gly Arg Thr 
    1745                 1750                 1755             


Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 
    1760                 1765                 1770             


Pro Glu  Tyr Tyr Pro Asn Ala  Gly Leu Ile Met Asn  Tyr Cys Arg 
    1775                 1780                 1785             


Asn Pro  Asp Ala Val Ala Ala  Pro Tyr Cys Tyr Thr  Arg Asp Pro 
    1790                 1795                 1800             


Gly Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Ser Asp Ala 
    1805                 1810                 1815             


Glu Gly  Thr Ala Val Ala Pro  Pro Thr Val Thr Pro  Val Pro Ser 
    1820                 1825                 1830             


Leu Glu  Ala Pro Ser Glu Gln  Ala Pro Thr Glu Gln  Arg Pro Gly 
    1835                 1840                 1845             


Val Gln  Glu Cys Tyr His Gly  Asn Gly Gln Ser Tyr  Arg Gly Thr 
    1850                 1855                 1860             


Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 
    1865                 1870                 1875             


Met Thr  Pro His Ser His Ser  Arg Thr Pro Glu Tyr  Tyr Pro Asn 
    1880                 1885                 1890             


Ala Gly  Leu Ile Met Asn Tyr  Cys Arg Asn Pro Asp  Ala Val Ala 
    1895                 1900                 1905             


Ala Pro  Tyr Cys Tyr Thr Arg  Asp Pro Gly Val Arg  Trp Glu Tyr 
    1910                 1915                 1920             


Cys Asn  Leu Thr Gln Cys Ser  Asp Ala Glu Gly Thr  Ala Val Ala 
    1925                 1930                 1935             


Pro Pro  Thr Val Thr Pro Val  Pro Ser Leu Glu Ala  Pro Ser Glu 
    1940                 1945                 1950             


Gln Ala  Pro Thr Glu Gln Arg  Pro Gly Val Gln Glu  Cys Tyr His 
    1955                 1960                 1965             


Gly Asn  Gly Gln Ser Tyr Arg  Gly Thr Tyr Ser Thr  Thr Val Thr 
    1970                 1975                 1980             


Gly Arg  Thr Cys Gln Ala Trp  Ser Ser Met Thr Pro  His Ser His 
    1985                 1990                 1995             


Ser Arg  Thr Pro Glu Tyr Tyr  Pro Asn Ala Gly Leu  Ile Met Asn 
    2000                 2005                 2010             


Tyr Cys  Arg Asn Pro Asp Ala  Val Ala Ala Pro Tyr  Cys Tyr Thr 
    2015                 2020                 2025             


Arg Asp  Pro Gly Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 
    2030                 2035                 2040             


Ser Asp  Ala Glu Gly Thr Ala  Val Ala Pro Pro Thr  Val Thr Pro 
    2045                 2050                 2055             


Val Pro  Ser Leu Glu Ala Pro  Ser Glu Gln Ala Pro  Thr Glu Gln 
    2060                 2065                 2070             


Arg Pro  Gly Val Gln Glu Cys  Tyr His Gly Asn Gly  Gln Ser Tyr 
    2075                 2080                 2085             


Arg Gly  Thr Tyr Ser Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ala 
    2090                 2095                 2100             


Trp Ser  Ser Met Thr Pro His  Ser His Ser Arg Thr  Pro Glu Tyr 
    2105                 2110                 2115             


Tyr Pro  Asn Ala Gly Leu Ile  Met Asn Tyr Cys Arg  Asn Pro Asp 
    2120                 2125                 2130             


Ala Val  Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 
    2135                 2140                 2145             


Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 
    2150                 2155                 2160             


Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 
    2165                 2170                 2175             


Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 
    2180                 2185                 2190             


Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    2195                 2200                 2205             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    2210                 2215                 2220             


His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 
    2225                 2230                 2235             


Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Ala Val Ala  Ala Pro Tyr 
    2240                 2245                 2250             


Cys Tyr  Thr Arg Asp Pro Gly  Val Arg Trp Glu Tyr  Cys Asn Leu 
    2255                 2260                 2265             


Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 
    2270                 2275                 2280             


Val Thr  Pro Val Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 
    2285                 2290                 2295             


Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 
    2300                 2305                 2310             


Gln Ser  Tyr Arg Gly Thr Tyr  Ser Thr Thr Val Thr  Gly Arg Thr 
    2315                 2320                 2325             


Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 
    2330                 2335                 2340             


Pro Glu  Tyr Tyr Pro Asn Ala  Gly Leu Ile Met Asn  Tyr Cys Arg 
    2345                 2350                 2355             


Asn Pro  Asp Ala Val Ala Ala  Pro Tyr Cys Tyr Thr  Arg Asp Pro 
    2360                 2365                 2370             


Gly Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Ser Asp Ala 
    2375                 2380                 2385             


Glu Gly  Thr Ala Val Ala Pro  Pro Thr Val Thr Pro  Val Pro Ser 
    2390                 2395                 2400             


Leu Glu  Ala Pro Ser Glu Gln  Ala Pro Thr Glu Gln  Arg Pro Gly 
    2405                 2410                 2415             


Val Gln  Glu Cys Tyr His Gly  Asn Gly Gln Ser Tyr  Arg Gly Thr 
    2420                 2425                 2430             


Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 
    2435                 2440                 2445             


Met Thr  Pro His Ser His Ser  Arg Thr Pro Glu Tyr  Tyr Pro Asn 
    2450                 2455                 2460             


Ala Gly  Leu Ile Met Asn Tyr  Cys Arg Asn Pro Asp  Ala Val Ala 
    2465                 2470                 2475             


Ala Pro  Tyr Cys Tyr Thr Arg  Asp Pro Gly Val Arg  Trp Glu Tyr 
    2480                 2485                 2490             


Cys Asn  Leu Thr Gln Cys Ser  Asp Ala Glu Gly Thr  Ala Val Ala 
    2495                 2500                 2505             


Pro Pro  Thr Val Thr Pro Val  Pro Ser Leu Glu Ala  Pro Ser Glu 
    2510                 2515                 2520             


Gln Ala  Pro Thr Glu Gln Arg  Pro Gly Val Gln Glu  Cys Tyr His 
    2525                 2530                 2535             


Gly Asn  Gly Gln Ser Tyr Arg  Gly Thr Tyr Ser Thr  Thr Val Thr 
    2540                 2545                 2550             


Gly Arg  Thr Cys Gln Ala Trp  Ser Ser Met Thr Pro  His Ser His 
    2555                 2560                 2565             


Ser Arg  Thr Pro Glu Tyr Tyr  Pro Asn Ala Gly Leu  Ile Met Asn 
    2570                 2575                 2580             


Tyr Cys  Arg Asn Pro Asp Ala  Val Ala Ala Pro Tyr  Cys Tyr Thr 
    2585                 2590                 2595             


Arg Asp  Pro Gly Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 
    2600                 2605                 2610             


Ser Asp  Ala Glu Gly Thr Ala  Val Ala Pro Pro Thr  Val Thr Pro 
    2615                 2620                 2625             


Val Pro  Ser Leu Glu Ala Pro  Ser Glu Gln Ala Pro  Thr Glu Gln 
    2630                 2635                 2640             


Arg Pro  Gly Val Gln Glu Cys  Tyr His Gly Asn Gly  Gln Ser Tyr 
    2645                 2650                 2655             


Arg Gly  Thr Tyr Ser Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ala 
    2660                 2665                 2670             


Trp Ser  Ser Met Thr Pro His  Ser His Ser Arg Thr  Pro Glu Tyr 
    2675                 2680                 2685             


Tyr Pro  Asn Ala Gly Leu Ile  Met Asn Tyr Cys Arg  Asn Pro Asp 
    2690                 2695                 2700             


Ala Val  Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 
    2705                 2710                 2715             


Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 
    2720                 2725                 2730             


Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 
    2735                 2740                 2745             


Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 
    2750                 2755                 2760             


Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    2765                 2770                 2775             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    2780                 2785                 2790             


His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 
    2795                 2800                 2805             


Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Ala Val Ala  Ala Pro Tyr 
    2810                 2815                 2820             


Cys Tyr  Thr Arg Asp Pro Gly  Val Arg Trp Glu Tyr  Cys Asn Leu 
    2825                 2830                 2835             


Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 
    2840                 2845                 2850             


Val Thr  Pro Val Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 
    2855                 2860                 2865             


Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 
    2870                 2875                 2880             


Gln Ser  Tyr Arg Gly Thr Tyr  Ser Thr Thr Val Thr  Gly Arg Thr 
    2885                 2890                 2895             


Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 
    2900                 2905                 2910             


Pro Glu  Tyr Tyr Pro Asn Ala  Gly Leu Ile Met Asn  Tyr Cys Arg 
    2915                 2920                 2925             


Asn Pro  Asp Ala Val Ala Ala  Pro Tyr Cys Tyr Thr  Arg Asp Pro 
    2930                 2935                 2940             


Gly Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Ser Asp Ala 
    2945                 2950                 2955             


Glu Gly  Thr Ala Val Ala Pro  Pro Thr Val Thr Pro  Val Pro Ser 
    2960                 2965                 2970             


Leu Glu  Ala Pro Ser Glu Gln  Ala Pro Thr Glu Gln  Arg Pro Gly 
    2975                 2980                 2985             


Val Gln  Glu Cys Tyr His Gly  Asn Gly Gln Ser Tyr  Arg Gly Thr 
    2990                 2995                 3000             


Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 
    3005                 3010                 3015             


Met Thr  Pro His Ser His Ser  Arg Thr Pro Glu Tyr  Tyr Pro Asn 
    3020                 3025                 3030             


Ala Gly  Leu Ile Met Asn Tyr  Cys Arg Asn Pro Asp  Ala Val Ala 
    3035                 3040                 3045             


Ala Pro  Tyr Cys Tyr Thr Arg  Asp Pro Gly Val Arg  Trp Glu Tyr 
    3050                 3055                 3060             


Cys Asn  Leu Thr Gln Cys Ser  Asp Ala Glu Gly Thr  Ala Val Ala 
    3065                 3070                 3075             


Pro Pro  Thr Val Thr Pro Val  Pro Ser Leu Glu Ala  Pro Ser Glu 
    3080                 3085                 3090             


Gln Ala  Pro Thr Glu Gln Arg  Pro Gly Val Gln Glu  Cys Tyr His 
    3095                 3100                 3105             


Gly Asn  Gly Gln Ser Tyr Arg  Gly Thr Tyr Ser Thr  Thr Val Thr 
    3110                 3115                 3120             


Gly Arg  Thr Cys Gln Ala Trp  Ser Ser Met Thr Pro  His Ser His 
    3125                 3130                 3135             


Ser Arg  Thr Pro Glu Tyr Tyr  Pro Asn Ala Gly Leu  Ile Met Asn 
    3140                 3145                 3150             


Tyr Cys  Arg Asn Pro Asp Ala  Val Ala Ala Pro Tyr  Cys Tyr Thr 
    3155                 3160                 3165             


Arg Asp  Pro Gly Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 
    3170                 3175                 3180             


Ser Asp  Ala Glu Gly Thr Ala  Val Ala Pro Pro Thr  Val Thr Pro 
    3185                 3190                 3195             


Val Pro  Ser Leu Glu Ala Pro  Ser Glu Gln Ala Pro  Thr Glu Gln 
    3200                 3205                 3210             


Arg Pro  Gly Val Gln Glu Cys  Tyr His Gly Asn Gly  Gln Ser Tyr 
    3215                 3220                 3225             


Arg Gly  Thr Tyr Ser Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ala 
    3230                 3235                 3240             


Trp Ser  Ser Met Thr Pro His  Ser His Ser Arg Thr  Pro Glu Tyr 
    3245                 3250                 3255             


Tyr Pro  Asn Ala Gly Leu Ile  Met Asn Tyr Cys Arg  Asn Pro Asp 
    3260                 3265                 3270             


Ala Val  Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 
    3275                 3280                 3285             


Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 
    3290                 3295                 3300             


Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 
    3305                 3310                 3315             


Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 
    3320                 3325                 3330             


Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    3335                 3340                 3345             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    3350                 3355                 3360             


His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 
    3365                 3370                 3375             


Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Pro Val Ala  Ala Pro Tyr 
    3380                 3385                 3390             


Cys Tyr  Thr Arg Asp Pro Ser  Val Arg Trp Glu Tyr  Cys Asn Leu 
    3395                 3400                 3405             


Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 
    3410                 3415                 3420             


Ile Thr  Pro Ile Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 
    3425                 3430                 3435             


Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 
    3440                 3445                 3450             


Gln Ser  Tyr Gln Gly Thr Tyr  Phe Ile Thr Val Thr  Gly Arg Thr 
    3455                 3460                 3465             


Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 
    3470                 3475                 3480             


Pro Ala  Tyr Tyr Pro Asn Ala  Gly Leu Ile Lys Asn  Tyr Cys Arg 
    3485                 3490                 3495             


Asn Pro  Asp Pro Val Ala Ala  Pro Trp Cys Tyr Thr  Thr Asp Pro 
    3500                 3505                 3510             


Ser Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Arg Cys  Ser Asp Ala 
    3515                 3520                 3525             


Glu Trp  Thr Ala Phe Val Pro  Pro Asn Val Ile Leu  Ala Pro Ser 
    3530                 3535                 3540             


Leu Glu  Ala Phe Phe Glu Gln  Ala Leu Thr Glu Glu  Thr Pro Gly 
    3545                 3550                 3555             


Val Gln  Asp Cys Tyr Tyr His  Tyr Gly Gln Ser Tyr  Arg Gly Thr 
    3560                 3565                 3570             


Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 
    3575                 3580                 3585             


Met Thr  Pro His Gln His Ser  Arg Thr Pro Glu Asn  Tyr Pro Asn 
    3590                 3595                 3600             


Ala Gly  Leu Thr Arg Asn Tyr  Cys Arg Asn Pro Asp  Ala Glu Ile 
    3605                 3610                 3615             


Arg Pro  Trp Cys Tyr Thr Met  Asp Pro Ser Val Arg  Trp Glu Tyr 
    3620                 3625                 3630             


Cys Asn  Leu Thr Gln Cys Leu  Val Thr Glu Ser Ser  Val Leu Ala 
    3635                 3640                 3645             


Thr Leu  Thr Val Val Pro Asp  Pro Ser Thr Glu Ala  Ser Ser Glu 
    3650                 3655                 3660             


Glu Ala  Pro Thr Glu Gln Ser  Pro Gly Val Gln Asp  Cys Tyr His 
    3665                 3670                 3675             


Gly Asp  Gly Gln Ser Tyr Arg  Gly Ser Phe Ser Thr  Thr Val Thr 
    3680                 3685                 3690             


Gly Arg  Thr Cys Gln Ser Trp  Ser Ser Met Thr Pro  His Trp His 
    3695                 3700                 3705             


Gln Arg  Thr Thr Glu Tyr Tyr  Pro Asn Gly Gly Leu  Thr Arg Asn 
    3710                 3715                 3720             


Tyr Cys  Arg Asn Pro Asp Ala  Glu Ile Ser Pro Trp  Cys Tyr Thr 
    3725                 3730                 3735             


Met Asp  Pro Asn Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 
    3740                 3745                 3750             


Pro Val  Thr Glu Ser Ser Val  Leu Ala Thr Ser Thr  Ala Val Ser 
    3755                 3760                 3765             


Glu Gln  Ala Pro Thr Glu Gln  Ser Pro Thr Val Gln  Asp Cys Tyr 
    3770                 3775                 3780             


His Gly  Asp Gly Gln Ser Tyr  Arg Gly Ser Phe Ser  Thr Thr Val 
    3785                 3790                 3795             


Thr Gly  Arg Thr Cys Gln Ser  Trp Ser Ser Met Thr  Pro His Trp 
    3800                 3805                 3810             


His Gln  Arg Thr Thr Glu Tyr  Tyr Pro Asn Gly Gly  Leu Thr Arg 
    3815                 3820                 3825             


Asn Tyr  Cys Arg Asn Pro Asp  Ala Glu Ile Arg Pro  Trp Cys Tyr 
    3830                 3835                 3840             


Thr Met  Asp Pro Ser Val Arg  Trp Glu Tyr Cys Asn  Leu Thr Gln 
    3845                 3850                 3855             


Cys Pro  Val Met Glu Ser Thr  Leu Leu Thr Thr Pro  Thr Val Val 
    3860                 3865                 3870             


Pro Val  Pro Ser Thr Glu Leu  Pro Ser Glu Glu Ala  Pro Thr Glu 
    3875                 3880                 3885             


Asn Ser  Thr Gly Val Gln Asp  Cys Tyr Arg Gly Asp  Gly Gln Ser 
    3890                 3895                 3900             


Tyr Arg  Gly Thr Leu Ser Thr  Thr Ile Thr Gly Arg  Thr Cys Gln 
    3905                 3910                 3915             


Ser Trp  Ser Ser Met Thr Pro  His Trp His Arg Arg  Ile Pro Leu 
    3920                 3925                 3930             


Tyr Tyr  Pro Asn Ala Gly Leu  Thr Arg Asn Tyr Cys  Arg Asn Pro 
    3935                 3940                 3945             


Asp Ala  Glu Ile Arg Pro Trp  Cys Tyr Thr Met Asp  Pro Ser Val 
    3950                 3955                 3960             


Arg Trp  Glu Tyr Cys Asn Leu  Thr Arg Cys Pro Val  Thr Glu Ser 
    3965                 3970                 3975             


Ser Val  Leu Thr Thr Pro Thr  Val Ala Pro Val Pro  Ser Thr Glu 
    3980                 3985                 3990             


Ala Pro  Ser Glu Gln Ala Pro  Pro Glu Lys Ser Pro  Val Val Gln 
    3995                 4000                 4005             


Asp Cys  Tyr His Gly Asp Gly  Arg Ser Tyr Arg Gly  Ile Ser Ser 
    4010                 4015                 4020             


Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ser Trp Ser  Ser Met Ile 
    4025                 4030                 4035             


Pro His  Trp His Gln Arg Thr  Pro Glu Asn Tyr Pro  Asn Ala Gly 
    4040                 4045                 4050             


Leu Thr  Glu Asn Tyr Cys Arg  Asn Pro Asp Ser Gly  Lys Gln Pro 
    4055                 4060                 4065             


Trp Cys  Tyr Thr Thr Asp Pro  Cys Val Arg Trp Glu  Tyr Cys Asn 
    4070                 4075                 4080             


Leu Thr  Gln Cys Ser Glu Thr  Glu Ser Gly Val Leu  Glu Thr Pro 
    4085                 4090                 4095             


Thr Val  Val Pro Val Pro Ser  Met Glu Ala His Ser  Glu Ala Ala 
    4100                 4105                 4110             


Pro Thr  Glu Gln Thr Pro Val  Val Arg Gln Cys Tyr  His Gly Asn 
    4115                 4120                 4125             


Gly Gln  Ser Tyr Arg Gly Thr  Phe Ser Thr Thr Val  Thr Gly Arg 
    4130                 4135                 4140             


Thr Cys  Gln Ser Trp Ser Ser  Met Thr Pro His Arg  His Gln Arg 
    4145                 4150                 4155             


Thr Pro  Glu Asn Tyr Pro Asn  Asp Gly Leu Thr Met  Asn Tyr Cys 
    4160                 4165                 4170             


Arg Asn  Pro Asp Ala Asp Thr  Gly Pro Trp Cys Phe  Thr Met Asp 
    4175                 4180                 4185             


Pro Ser  Ile Arg Trp Glu Tyr  Cys Asn Leu Thr Arg  Cys Ser Asp 
    4190                 4195                 4200             


Thr Glu  Gly Thr Val Val Ala  Pro Pro Thr Val Ile  Gln Val Pro 
    4205                 4210                 4215             


Ser Leu  Gly Pro Pro Ser Glu  Gln Asp Cys Met Phe  Gly Asn Gly 
    4220                 4225                 4230             


Lys Gly  Tyr Arg Gly Lys Lys  Ala Thr Thr Val Thr  Gly Thr Pro 
    4235                 4240                 4245             


Cys Gln  Glu Trp Ala Ala Gln  Glu Pro His Arg His  Ser Thr Phe 
    4250                 4255                 4260             


Ile Pro  Gly Thr Asn Lys Trp  Ala Gly Leu Glu Lys  Asn Tyr Cys 
    4265                 4270                 4275             


Arg Asn  Pro Asp Gly Asp Ile  Asn Gly Pro Trp Cys  Tyr Thr Met 
    4280                 4285                 4290             


Asn Pro  Arg Lys Leu Phe Asp  Tyr Cys Asp Ile Pro  Leu Cys Ala 
    4295                 4300                 4305             


Ser Ser  Ser Phe Asp Cys Gly  Lys Pro Gln Val Glu  Pro Lys Lys 
    4310                 4315                 4320             


Cys Pro  Gly Ser Ile Val Gly  Gly Cys Val Ala His  Pro His Ser 
    4325                 4330                 4335             


Trp Pro  Trp Gln Val Ser Leu  Arg Thr Arg Phe Gly  Lys His Phe 
    4340                 4345                 4350             


Cys Gly  Gly Thr Leu Ile Ser  Pro Glu Trp Val Leu  Thr Ala Ala 
    4355                 4360                 4365             


His Cys  Leu Lys Lys Ser Ser  Arg Pro Ser Ser Tyr  Lys Val Ile 
    4370                 4375                 4380             


Leu Gly  Ala His Gln Glu Val  Asn Leu Glu Ser His  Val Gln Glu 
    4385                 4390                 4395             


Ile Glu  Val Ser Arg Leu Phe  Leu Glu Pro Thr Gln  Ala Asp Ile 
    4400                 4405                 4410             


Ala Leu  Leu Lys Leu Ser Arg  Pro Ala Val Ile Thr  Asp Lys Val 
    4415                 4420                 4425             


Met Pro  Ala Cys Leu Pro Ser  Pro Asp Tyr Met Val  Thr Ala Arg 
    4430                 4435                 4440             


Thr Glu  Cys Tyr Ile Thr Gly  Trp Gly Glu Thr Gln  Gly Thr Phe 
    4445                 4450                 4455             


Gly Thr  Gly Leu Leu Lys Glu  Ala Gln Leu Leu Val  Ile Glu Asn 
    4460                 4465                 4470             


Glu Val  Cys Asn His Tyr Lys  Tyr Ile Cys Ala Glu  His Leu Ala 
    4475                 4480                 4485             


Arg Gly  Thr Asp Ser Cys Gln  Gly Asp Ser Gly Gly  Pro Leu Val 
    4490                 4495                 4500             


Cys Phe  Glu Lys Asp Lys Tyr  Ile Leu Gln Gly Val  Thr Ser Trp 
    4505                 4510                 4515             


Gly Leu  Gly Cys Ala Arg Pro  Asn Lys Pro Gly Val  Tyr Ala Arg 
    4520                 4525                 4530             


Val Ser  Arg Phe Val Thr Trp  Ile Glu Gly Met Met  Arg Asn Asn 
    4535                 4540                 4545             


<210> 31
<211> 317
<212> PRT
<213> Homo sapiens

<400> 31
Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg 
    210                 215                 220                 


Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly 
225                 230                 235                 240 


Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu 
                245                 250                 255     


Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 
            260                 265                 270         


Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 
        275                 280                 285             


Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 
    290                 295                 300                 


Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
305                 310                 315         


<210> 32
<211> 138
<212> PRT
<213> Homo sapiens

<400> 32
Met Thr Ala Leu Phe Leu Met Ser Met Leu Phe Gly Leu Ala Cys Gly 
1               5                   10                  15      


Gln Ala Met Ser Phe Cys Ile Pro Thr Glu Tyr Thr Met His Ile Glu 
            20                  25                  30          


Arg Arg Glu Cys Ala Tyr Cys Leu Thr Ile Asn Thr Thr Ile Cys Ala 
        35                  40                  45              


Gly Tyr Cys Met Thr Arg Asp Ile Asn Gly Lys Leu Phe Leu Pro Lys 
    50                  55                  60                  


Tyr Ala Leu Ser Gln Asp Val Cys Thr Tyr Arg Asp Phe Ile Tyr Arg 
65                  70                  75                  80  


Thr Val Glu Ile Pro Gly Cys Pro Leu His Val Ala Pro Tyr Phe Ser 
                85                  90                  95      


Tyr Pro Val Ala Leu Ser Cys Lys Cys Gly Lys Cys Asn Thr Asp Tyr 
            100                 105                 110         


Ser Asp Cys Ile His Glu Ala Ile Lys Thr Asn Tyr Cys Thr Lys Pro 
        115                 120                 125             


Gln Lys Ser Tyr Leu Val Gly Phe Ser Val 
    130                 135             


<210> 33
<211> 241
<212> PRT
<213> Homo sapiens

<400> 33
Met Asn Arg Cys Trp Ala Leu Phe Leu Ser Leu Cys Cys Tyr Leu Arg 
1               5                   10                  15      


Leu Val Ser Ala Glu Gly Asp Pro Ile Pro Glu Glu Leu Tyr Glu Met 
            20                  25                  30          


Leu Ser Asp His Ser Ile Arg Ser Phe Asp Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


His Gly Asp Pro Gly Glu Glu Asp Gly Ala Glu Leu Asp Leu Asn Met 
    50                  55                  60                  


Thr Arg Ser His Ser Gly Gly Glu Leu Glu Ser Leu Ala Arg Gly Arg 
65                  70                  75                  80  


Arg Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala Glu 
                85                  90                  95      


Cys Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp 
            100                 105                 110         


Arg Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln 
        115                 120                 125             


Arg Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro Thr 
    130                 135                 140                 


Gln Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg 
145                 150                 155                 160 


Lys Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu 
                165                 170                 175     


Ala Cys Lys Cys Glu Thr Val Ala Ala Ala Arg Pro Val Thr Arg Ser 
            180                 185                 190         


Pro Gly Gly Ser Gln Glu Gln Arg Ala Lys Thr Pro Gln Thr Arg Val 
        195                 200                 205             


Thr Ile Arg Thr Val Arg Val Arg Arg Pro Pro Lys Gly Lys His Arg 
    210                 215                 220                 


Lys Phe Lys His Thr His Asp Lys Thr Ala Leu Lys Glu Thr Leu Gly 
225                 230                 235                 240 


Ala 
    


<210> 34
<211> 155
<212> PRT
<213> Homo sapiens

<400> 34
Met Glu Arg Ile Val Ile Cys Leu Met Val Ile Phe Leu Gly Thr Leu 
1               5                   10                  15      


Val His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met Ile Arg Met 
            20                  25                  30          


Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp 
        35                  40                  45              


Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys 
    50                  55                  60                  


Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala 
65                  70                  75                  80  


Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu 
                85                  90                  95      


Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg 
            100                 105                 110         


Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu 
        115                 120                 125             


Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His 
    130                 135                 140                 


Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
145                 150                 155 


<210> 35
<211> 10
<212> PRT
<213> Homo sapiens

<400> 35
Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu 
1               5                   10  


