                         SEQUENCE LISTING

<110>  Garvan Institute of Medical Research
 
<120>  Treatment of abnormalities of glucose metabolism

<130>  510888

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  1234
<212>  DNA
<213>  Homo sapiens

<400>  1
attccacgtt cttaactgtt ccattttccg tatctgcttc gggcttccac ctcatttttt       60

tcgctttgcc cattctgttt cagccagtcg ccaagaatca tgaaagtcgc cagtggcagc      120

accgccaccg ccgccgcggg ccccagctgc gcgctgaagg ccggcaagac agcgagcggt      180

gcgggcgagg tggtgcgctg tctgtctgag cagagcgtgg ccatctcgcg ctgcgccggg      240

ggcgccgggg cgcgcctgcc tgccctgctg gacgagcagc aggtaaacgt gctgctctac      300

gacatgaacg gctgttactc acgcctcaag gagctggtgc ccaccctgcc ccagaaccgc      360

aaggtgagca aggtggagat tctccagcac gtcatcgact acatcaggga ccttcagttg      420

gagctgaact cggaatccga agttggaacc cccgggggcc gagggctgcc ggtccgggct      480

ccgctcagca ccctcaacgg cgagatcagc gccctgacgg ccgaggtgag atccagatcc      540

gaccactaga tcatccttat accgacgggg aaacggaggc cagagagggc gtgggcgctt      600

gcaccacttc cgtcccatcc ttgcgggtac ctggctatgc gggggtgcct aaggagcctg      660

gaaaaagcgc tcccccgtcg tgcttcctgg ggaagggggc gttcgctgcg ctcggagcgg      720

cgtcccttcc aacccgccgg tctcatttct tctcgttttc acaggcggca tgcgttcctg      780

cggacgatcg catcttgtgt cgctgaagcg cctcccccag ggaccggcgg accccagcca      840

tccagggggc aagaggaatt acgtgctctg tgggtctccc ccaacgcgcc tcgccggatc      900

tgagggagaa caagaccgat cggcggccac tgcgccctta actgcatcca gcctggggct      960

gaggctgagg cactggcgag gagagggcgc tcctctctgc acacctacta gtcaccagag     1020

actttagggg gtgggattcc actcgtgtgt ttctattttt tgaaaagcag acattttaaa     1080

aaatggtcac gtttggtgct tctcagattt ctgaggaaat tgctttgtat tgtatattac     1140

aatgatcacc gactgaaaat attgttttac aatagttctg tggggctgtt tttttgttat     1200

taaacaaata atttagatgg tgaaaaaaaa aaaa                                 1234


<210>  2
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Val Ala Ser Gly Ser Thr Ala Thr Ala Ala Ala Gly Pro Ser 
1               5                   10                  15      


Cys Ala Leu Lys Ala Gly Lys Thr Ala Ser Gly Ala Gly Glu Val Val 
            20                  25                  30          


Arg Cys Leu Ser Glu Gln Ser Val Ala Ile Ser Arg Cys Ala Gly Gly 
        35                  40                  45              


Ala Gly Ala Arg Leu Pro Ala Leu Leu Asp Glu Gln Gln Val Asn Val 
    50                  55                  60                  


Leu Leu Tyr Asp Met Asn Gly Cys Tyr Ser Arg Leu Lys Glu Leu Val 
65                  70                  75                  80  


Pro Thr Leu Pro Gln Asn Arg Lys Val Ser Lys Val Glu Ile Leu Gln 
                85                  90                  95      


His Val Ile Asp Tyr Ile Arg Asp Leu Gln Leu Glu Leu Asn Ser Glu 
            100                 105                 110         


Ser Glu Val Gly Thr Pro Gly Gly Arg Gly Leu Pro Val Arg Ala Pro 
        115                 120                 125             


Leu Ser Thr Leu Asn Gly Glu Ile Ser Ala Leu Thr Ala Glu Val Arg 
    130                 135                 140                 


Ser Arg Ser Asp His 
145                 


<210>  3
<211>  993
<212>  DNA
<213>  Homo sapiens

<400>  3
attccacgtt cttaactgtt ccattttccg tatctgcttc gggcttccac ctcatttttt       60

tcgctttgcc cattctgttt cagccagtcg ccaagaatca tgaaagtcgc cagtggcagc      120

accgccaccg ccgccgcggg ccccagctgc gcgctgaagg ccggcaagac agcgagcggt      180

gcgggcgagg tggtgcgctg tctgtctgag cagagcgtgg ccatctcgcg ctgcgccggg      240

ggcgccgggg cgcgcctgcc tgccctgctg gacgagcagc aggtaaacgt gctgctctac      300

gacatgaacg gctgttactc acgcctcaag gagctggtgc ccaccctgcc ccagaaccgc      360

aaggtgagca aggtggagat tctccagcac gtcatcgact acatcaggga ccttcagttg      420

gagctgaact cggaatccga agttggaacc cccgggggcc gagggctgcc ggtccgggct      480

ccgctcagca ccctcaacgg cgagatcagc gccctgacgg ccgaggcggc atgcgttcct      540

gcggacgatc gcatcttgtg tcgctgaagc gcctccccca gggaccggcg gaccccagcc      600

atccaggggg caagaggaat tacgtgctct gtgggtctcc cccaacgcgc ctcgccggat      660

ctgagggaga acaagaccga tcggcggcca ctgcgccctt aactgcatcc agcctggggc      720

tgaggctgag gcactggcga ggagagggcg ctcctctctg cacacctact agtcaccaga      780

gactttaggg ggtgggattc cactcgtgtg tttctatttt ttgaaaagca gacattttaa      840

aaaatggtca cgtttggtgc ttctcagatt tctgaggaaa ttgctttgta ttgtatatta      900

caatgatcac cgactgaaaa tattgtttta caatagttct gtggggctgt ttttttgtta      960

ttaaacaaat aatttagatg gtgaaaaaaa aaa                                   993


<210>  4
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Val Ala Ser Gly Ser Thr Ala Thr Ala Ala Ala Gly Pro Ser 
1               5                   10                  15      


Cys Ala Leu Lys Ala Gly Lys Thr Ala Ser Gly Ala Gly Glu Val Val 
            20                  25                  30          


Arg Cys Leu Ser Glu Gln Ser Val Ala Ile Ser Arg Cys Ala Gly Gly 
        35                  40                  45              


Ala Gly Ala Arg Leu Pro Ala Leu Leu Asp Glu Gln Gln Val Asn Val 
    50                  55                  60                  


Leu Leu Tyr Asp Met Asn Gly Cys Tyr Ser Arg Leu Lys Glu Leu Val 
65                  70                  75                  80  


Pro Thr Leu Pro Gln Asn Arg Lys Val Ser Lys Val Glu Ile Leu Gln 
                85                  90                  95      


His Val Ile Asp Tyr Ile Arg Asp Leu Gln Leu Glu Leu Asn Ser Glu 
            100                 105                 110         


Ser Glu Val Gly Thr Pro Gly Gly Arg Gly Leu Pro Val Arg Ala Pro 
        115                 120                 125             


Leu Ser Thr Leu Asn Gly Glu Ile Ser Ala Leu Thr Ala Glu Ala Ala 
    130                 135                 140                 


Cys Val Pro Ala Asp Asp Arg Ile Leu Cys Arg 
145                 150                 155 


<210>  5
<211>  16
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Id1 antagonistic peptide

<400>  5

Glu Leu Leu Ile Leu Gln Arg Leu Val Gln Val Ile Leu Ala Leu Gln 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  peptide antagonist of Id1.

<400>  6

Glu Leu Leu Phe Leu Gln Arg Leu Val Gln Leu Ile Leu Ala Leu Gln 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  peptide antagonist of Id1.

<400>  7

Glu Leu Leu Phe Leu Gln Ala Leu Val Gln Leu Ile Leu Ala Leu Gln 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  peptide antagonist of Id1.

<400>  8

Glu Leu Leu Phe Leu Gln Arg Leu Val Gln Leu Ile Glu Ala Leu Gln 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  peptide antagonist of Id1.

<400>  9

Asp Leu Leu Leu Leu Gln Arg Leu Val Gln Leu Ile Glu Ala Leu Gln 
1               5                   10                  15      


<210>  10
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  peptide antagonist of Id1.

<400>  10

Asp Leu Leu Phe Leu Gln Arg Leu Val Gln Leu Ile Glu Ala Leu Gln 
1               5                   10                  15      


<210>  11
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  Id1 antagonistic peptide

<400>  11

Glu Leu Lys Phe Leu Gln Arg Leu Val Gln Leu Ile Glu Ala Leu Gln 
1               5                   10                  15      


<210>  12
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  peptide antagonist of Id1.

<400>  12

Glu Leu Glu Phe Leu Gln Arg Leu Val Gln Leu Ile Glu Ala Leu Gln 
1               5                   10                  15      


<210>  13
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  peptide antagonist of Id1.

<400>  13

Glu Leu Glu Phe Leu Gln Arg Leu Val Asp Leu Ile Glu Lys Leu Gln 
1               5                   10                  15      


<210>  14
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  peptide antagonist of Id1.

<400>  14

Asp Leu Glu Phe Leu Gln Arg Leu Val Asp Leu Ile Glu Lys Leu Gln 
1               5                   10                  15      


<210>  15
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  peptide antagonist of Id1.

<400>  15

Glu Leu Lys Phe Leu Gln Arg Leu Val Asp Leu Ile Glu Lys Leu Gln 
1               5                   10                  15      


<210>  16
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  peptide antagonist of Id1.

<400>  16

Glu Leu Lys Phe Leu Gln Arg Leu Val Asp Leu Ile Glu Lys Leu Glu 
1               5                   10                  15      


<210>  17
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  Antisense for silencing Id1 expression

<400>  17
gcaccagctc cttgaggcgt gag                                               23


<210>  18
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  Anstisense for silencing Id1 expression

<400>  18
gcaccagctc cttgaggcgu gag                                               23


<210>  19
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Anstisense for silencing Id1 expression

<400>  19
ggcggcggtg gcggtgctgc                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Anstisense for silencing Id1 expression

<400>  20
gacgtgctgg agaatctcca                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Antisesnse for silencing Id1 expression

<400>  21
tgaggtggaa gcccgaagca                                                   20


<210>  22
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  Pancreas targeting peptide

<400>  22

Leu Ser Gly Thr Pro Glu Arg Ser Gly Gln Ala Val Lys Val Lys Leu 
1               5                   10                  15      


Lys Ala Ile Pro 
            20  


<210>  23
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  Pancreas targeting peptide

<400>  23

Gly Ala Trp Glu Ala Arg Asp Arg Ile Ala Glu Trp Gly Ser Trp Gly 
1               5                   10                  15      


Ile Pro Ser 
            


<210>  24
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Pancreatic islet targeting peptide

<400>  24

Cys Val Ser Asn Pro Arg Trp Lys Cys 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Pancreatic islet targeting peptide

<400>  25

Cys His Val Leu Trp Ser Thr Arg Cys 
1               5                   


<210>  26
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  HIV-1 TAT protein transduction domain

<400>  26

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  27
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  Antennapedia protein transduction domain

<400>  27

Gly Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Lys 
    


<210>  28
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Id1 peptide antagonist

<400>  28

Tyr Ile Glu Gly Leu Gln Ala Leu Leu Arg Asp Gln 
1               5                   10          


<210>  29
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Cyclophilin A (Ppia)

<400>  29
tgtgccaggg tggtgacttt ac                                                22


<210>  30
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Cyclophilin A (Ppia)

<400>  30
tgggaaccgt ttgtgtttgg                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Id1

<400>  31
ttggtctgtc ggagcaaagc                                                   20


<210>  32
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Id1

<400>  32
gcaggtccct gatgtagtcg attac                                             25


<210>  33
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying insulin mRNA

<400>  33
tcttctacac acccatgtcc c                                                 21


<210>  34
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying insulin mRNA

<400>  34
ggtgcagcac tgatctac                                                     18


<210>  35
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying glucagon mRNA

<400>  35
atgaatgaag acaaacgcca c                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying glucagon mRNA

<400>  36
acttcttctg ggaagtctcg c                                                 21


<210>  37
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying pdx1 cDNA

<400>  37
cggacatctc cccatacg                                                     18


<210>  38
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying pdx1 cDNA

<400>  38
aaagggagct ggacgcgg                                                     18


<210>  39
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Beta2 (Neurod1) cDNA

<400>  39
actccaagac ccagaaactg tc                                                22


<210>  40
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Beta2 (Neurod1) cDNA

<400>  40
actggtagga gtagggatgc ac                                                22


<210>  41
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Glut2 (Slc2a2) cDNA

<400>  41
cattctttgg tgggtggc                                                     18


<210>  42
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Glut2 (Slc2a2) cDNA

<400>  42
cctgagtgtg tttggagcg                                                    19


<210>  43
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Pc (Pcx) cDNA

<400>  43
gttccgtgtc cgaggtgtaa ag                                                22


<210>  44
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Pc (Pcx) cDNA

<400>  44
cgcagaagga tgtccctgaa ac                                                22


<210>  45
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Gk (Gck) cDNA

<400>  45
cattgaatca gaggagggca gc                                                22


<210>  46
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Gk (Gck) cDNA

<400>  46
tagtggactg ggagcatttg tggg                                              24


<210>  47
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Gpr40 (Ffar1) cDNA

<400>  47
tattcctggg gtgtgtgtgt gg                                                22


<210>  48
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Gpr40 (Ffar1) cDNA

<400>  48
ccaagggcag aaagaagagc ag                                                22


<210>  49
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying BiP (Hspa5)

<400>  49
aggacaagaa ggaggatgtg gg                                                22


<210>  50
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying BiP (Hspa5)

<400>  50
accgaagggt cattccaagt g                                                 21


<210>  51
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Chop (Ddit3) cDNA

<400>  51
ttcactactc ttgaccctgc gtc                                               23


<210>  52
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Chop (Ddit3) cDNA

<400>  52
cactgaccac tctgtttccg tttc                                              24


<210>  53
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Ho-1 (Hmox1) cDNA

<400>  53
cactgaccac tctgtttccg tttc                                              24


<210>  54
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide for amplifying Ho-1 (Hmox1) cDNA

<400>  54
gttcgggaag gtaaaaaaag cc                                                22


