                         SEQUENCE LISTING

<110>  Ventana Medical Systems, Inc.
       Hong, Rui
       Wang, Hong
       Lefever, Mark
       Froehlich, Jan T
       Bieniarz, Christopher
       Kelly, Brian D
       Miller, Phillip
 
<120>  DETECTING TARGETS USING MASS TAGS AND MASS SPECTROMETRY

<130>  7668-87482-01

<150>  US 61/398,944
<151>  2010-07-02

<150>  US 61/398,942
<151>  2010-07-02

<150>  US 61/464,937
<151>  2011-03-11

<150>  US 61/464,977
<151>  2011-03-11

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  2
<211>  5616
<212>  DNA
<213>  Homo sapiens

<400>  2
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg       60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac      120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc      180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga      240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc      300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc      360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt      420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc      480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga      540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc      600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga      660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac      720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg      780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc      840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag      900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca      960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc     1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat     1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat     1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg     1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac     1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac     1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt     1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta     1440

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat     1500

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt     1560

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat     1620

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa     1680

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc     1740

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg     1800

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag     1860

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc     1920

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac     1980

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga     2040

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac     2100

ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg     2160

aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg     2220

gtggtggccc tggggatcgg cctcttcatg cgaaggcgcc acatcgttcg gaagcgcacg     2280

ctgcggaggc tgctgcagga gagggagctt gtggagcctc ttacacccag tggagaagct     2340

cccaaccaag ctctcttgag gatcttgaag gaaactgaat tcaaaaagat caaagtgctg     2400

ggctccggtg cgttcggcac ggtgtataag ggactctgga tcccagaagg tgagaaagtt     2460

aaaattcccg tcgctatcaa ggaattaaga gaagcaacat ctccgaaagc caacaaggaa     2520

atcctcgatg aagcctacgt gatggccagc gtggacaacc cccacgtgtg ccgcctgctg     2580

ggcatctgcc tcacctccac cgtgcagctc atcacgcagc tcatgccctt cggctgcctc     2640

ctggactatg tccgggaaca caaagacaat attggctccc agtacctgct caactggtgt     2700

gtgcagatcg caaagggcat gaactacttg gaggaccgtc gcttggtgca ccgcgacctg     2760

gcagccagga acgtactggt gaaaacaccg cagcatgtca agatcacaga ttttgggctg     2820

gccaaactgc tgggtgcgga agagaaagaa taccatgcag aaggaggcaa agtgcctatc     2880

aagtggatgg cattggaatc aattttacac agaatctata cccaccagag tgatgtctgg     2940

agctacgggg tgaccgtttg ggagttgatg acctttggat ccaagccata tgacggaatc     3000

cctgccagcg agatctcctc catcctggag aaaggagaac gcctccctca gccacccata     3060

tgtaccatcg atgtctacat gatcatggtc aagtgctgga tgatagacgc agatagtcgc     3120

ccaaagttcc gtgagttgat catcgaattc tccaaaatgg cccgagaccc ccagcgctac     3180

cttgtcattc agggggatga aagaatgcat ttgccaagtc ctacagactc caacttctac     3240

cgtgccctga tggatgaaga agacatggac gacgtggtgg atgccgacga gtacctcatc     3300

ccacagcagg gcttcttcag cagcccctcc acgtcacgga ctcccctcct gagctctctg     3360

agtgcaacca gcaacaattc caccgtggct tgcattgata gaaatgggct gcaaagctgt     3420

cccatcaagg aagacagctt cttgcagcga tacagctcag accccacagg cgccttgact     3480

gaggacagca tagacgacac cttcctccca gtgcctgaat acataaacca gtccgttccc     3540

aaaaggcccg ctggctctgt gcagaatcct gtctatcaca atcagcctct gaaccccgcg     3600

cccagcagag acccacacta ccaggacccc cacagcactg cagtgggcaa ccccgagtat     3660

ctcaacactg tccagcccac ctgtgtcaac agcacattcg acagccctgc ccactgggcc     3720

cagaaaggca gccaccaaat tagcctggac aaccctgact accagcagga cttctttccc     3780

aaggaagcca agccaaatgg catctttaag ggctccacag ctgaaaatgc agaataccta     3840

agggtcgcgc cacaaagcag tgaatttatt ggagcatgac cacggaggat agtatgagcc     3900

ctaaaaatcc agactctttc gatacccagg accaagccac agcaggtcct ccatcccaac     3960

agccatgccc gcattagctc ttagacccac agactggttt tgcaacgttt acaccgacta     4020

gccaggaagt acttccacct cgggcacatt ttgggaagtt gcattccttt gtcttcaaac     4080

tgtgaagcat ttacagaaac gcatccagca agaatattgt ccctttgagc agaaatttat     4140

ctttcaaaga ggtatatttg aaaaaaaaaa aaagtatatg tgaggatttt tattgattgg     4200

ggatcttgga gtttttcatt gtcgctattg atttttactt caatgggctc ttccaacaag     4260

gaagaagctt gctggtagca cttgctaccc tgagttcatc caggcccaac tgtgagcaag     4320

gagcacaagc cacaagtctt ccagaggatg cttgattcca gtggttctgc ttcaaggctt     4380

ccactgcaaa acactaaaga tccaagaagg ccttcatggc cccagcaggc cggatcggta     4440

ctgtatcaag tcatggcagg tacagtagga taagccactc tgtcccttcc tgggcaaaga     4500

agaaacggag gggatggaat tcttccttag acttactttt gtaaaaatgt ccccacggta     4560

cttactcccc actgatggac cagtggtttc cagtcatgag cgttagactg acttgtttgt     4620

cttccattcc attgttttga aactcagtat gctgcccctg tcttgctgtc atgaaatcag     4680

caagagagga tgacacatca aataataact cggattccag cccacattgg attcatcagc     4740

atttggacca atagcccaca gctgagaatg tggaatacct aaggatagca ccgcttttgt     4800

tctcgcaaaa acgtatctcc taatttgagg ctcagatgaa atgcatcagg tcctttgggg     4860

catagatcag aagactacaa aaatgaagct gctctgaaat ctcctttagc catcacccca     4920

accccccaaa attagtttgt gttacttatg gaagatagtt ttctcctttt acttcacttc     4980

aaaagctttt tactcaaaga gtatatgttc cctccaggtc agctgccccc aaaccccctc     5040

cttacgcttt gtcacacaaa aagtgtctct gccttgagtc atctattcaa gcacttacag     5100

ctctggccac aacagggcat tttacaggtg cgaatgacag tagcattatg agtagtgtgg     5160

aattcaggta gtaaatatga aactagggtt tgaaattgat aatgctttca caacatttgc     5220

agatgtttta gaaggaaaaa agttccttcc taaaataatt tctctacaat tggaagattg     5280

gaagattcag ctagttagga gcccaccttt tttcctaatc tgtgtgtgcc ctgtaacctg     5340

actggttaac agcagtcctt tgtaaacagt gttttaaact ctcctagtca atatccaccc     5400

catccaattt atcaaggaag aaatggttca gaaaatattt tcagcctaca gttatgttca     5460

gtcacacaca catacaaaat gttccttttg cttttaaagt aatttttgac tcccagatca     5520

gtcagagccc ctacagcatt gttaagaaag tatttgattt ttgtctcaat gaaaataaaa     5580

ctatattcat ttccactcta aaaaaaaaaa aaaaaa                               5616


<210>  3
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


<210>  4
<211>  4624
<212>  DNA
<213>  Homo sapiens

<400>  4
ggaggaggtg gaggaggagg gctgcttgag gaagtataag aatgaagttg tgaagctgag       60

attcccctcc attgggaccg gagaaaccag gggagccccc cgggcagccg cgcgcccctt      120

cccacggggc cctttactgc gccgcgcgcc cggcccccac ccctcgcagc accccgcgcc      180

ccgcgccctc ccagccgggt ccagccggag ccatggggcc ggagccgcag tgagcaccat      240

ggagctggcg gccttgtgcc gctgggggct cctcctcgcc ctcttgcccc ccggagccgc      300

gagcacccaa gtgtgcaccg gcacagacat gaagctgcgg ctccctgcca gtcccgagac      360

ccacctggac atgctccgcc acctctacca gggctgccag gtggtgcagg gaaacctgga      420

actcacctac ctgcccacca atgccagcct gtccttcctg caggatatcc aggaggtgca      480

gggctacgtg ctcatcgctc acaaccaagt gaggcaggtc ccactgcaga ggctgcggat      540

tgtgcgaggc acccagctct ttgaggacaa ctatgccctg gccgtgctag acaatggaga      600

cccgctgaac aataccaccc ctgtcacagg ggcctcccca ggaggcctgc gggagctgca      660

gcttcgaagc ctcacagaga tcttgaaagg aggggtcttg atccagcgga acccccagct      720

ctgctaccag gacacgattt tgtggaagga catcttccac aagaacaacc agctggctct      780

cacactgata gacaccaacc gctctcgggc ctgccacccc tgttctccga tgtgtaaggg      840

ctcccgctgc tggggagaga gttctgagga ttgtcagagc ctgacgcgca ctgtctgtgc      900

cggtggctgt gcccgctgca aggggccact gcccactgac tgctgccatg agcagtgtgc      960

tgccggctgc acgggcccca agcactctga ctgcctggcc tgcctccact tcaaccacag     1020

tggcatctgt gagctgcact gcccagccct ggtcacctac aacacagaca cgtttgagtc     1080

catgcccaat cccgagggcc ggtatacatt cggcgccagc tgtgtgactg cctgtcccta     1140

caactacctt tctacggacg tgggatcctg caccctcgtc tgccccctgc acaaccaaga     1200

ggtgacagca gaggatggaa cacagcggtg tgagaagtgc agcaagccct gtgcccgagt     1260

gtgctatggt ctgggcatgg agcacttgcg agaggtgagg gcagttacca gtgccaatat     1320

ccaggagttt gctggctgca agaagatctt tgggagcctg gcatttctgc cggagagctt     1380

tgatggggac ccagcctcca acactgcccc gctccagcca gagcagctcc aagtgtttga     1440

gactctggaa gagatcacag gttacctata catctcagca tggccggaca gcctgcctga     1500

cctcagcgtc ttccagaacc tgcaagtaat ccggggacga attctgcaca atggcgccta     1560

ctcgctgacc ctgcaagggc tgggcatcag ctggctgggg ctgcgctcac tgagggaact     1620

gggcagtgga ctggccctca tccaccataa cacccacctc tgcttcgtgc acacggtgcc     1680

ctgggaccag ctctttcgga acccgcacca agctctgctc cacactgcca accggccaga     1740

ggacgagtgt gtgggcgagg gcctggcctg ccaccagctg tgcgcccgag ggcactgctg     1800

gggtccaggg cccacccagt gtgtcaactg cagccagttc cttcggggcc aggagtgcgt     1860

ggaggaatgc cgagtactgc aggggctccc cagggagtat gtgaatgcca ggcactgttt     1920

gccgtgccac cctgagtgtc agccccagaa tggctcagtg acctgttttg gaccggaggc     1980

tgaccagtgt gtggcctgtg cccactataa ggaccctccc ttctgcgtgg cccgctgccc     2040

cagcggtgtg aaacctgacc tctcctacat gcccatctgg aagtttccag atgaggaggg     2100

cgcatgccag ccttgcccca tcaactgcac ccactcctgt gtggacctgg atgacaaggg     2160

ctgccccgcc gagcagagag ccagccctct gacgtccatc atctctgcgg tggttggcat     2220

tctgctggtc gtggtcttgg gggtggtctt tgggatcctc atcaagcgac ggcagcagaa     2280

gatccggaag tacacgatgc ggagactgct gcaggaaacg gagctggtgg agccgctgac     2340

acctagcgga gcgatgccca accaggcgca gatgcggatc ctgaaagaga cggagctgag     2400

gaaggtgaag gtgcttggat ctggcgcttt tggcacagtc tacaagggca tctggatccc     2460

tgatggggag aatgtgaaaa ttccagtggc catcaaagtg ttgagggaaa acacatcccc     2520

caaagccaac aaagaaatct tagacgaagc atacgtgatg gctggtgtgg gctccccata     2580

tgtctcccgc cttctgggca tctgcctgac atccacggtg cagctggtga cacagcttat     2640

gccctatggc tgcctcttag accatgtccg ggaaaaccgc ggacgcctgg gctcccagga     2700

cctgctgaac tggtgtatgc agattgccaa ggggatgagc tacctggagg atgtgcggct     2760

cgtacacagg gacttggccg ctcggaacgt gctggtcaag agtcccaacc atgtcaaaat     2820

tacagacttc gggctggctc ggctgctgga cattgacgag acagagtacc atgcagatgg     2880

gggcaaggtg cccatcaagt ggatggcgct ggagtccatt ctccgccggc ggttcaccca     2940

ccagagtgat gtgtggagtt atggtgtgac tgtgtgggag ctgatgactt ttggggccaa     3000

accttacgat gggatcccag cccgggagat ccctgacctg ctggaaaagg gggagcggct     3060

gccccagccc cccatctgca ccattgatgt ctacatgatc atggtcaaat gttggatgat     3120

tgactctgaa tgtcggccaa gattccggga gttggtgtct gaattctccc gcatggccag     3180

ggacccccag cgctttgtgg tcatccagaa tgaggacttg ggcccagcca gtcccttgga     3240

cagcaccttc taccgctcac tgctggagga cgatgacatg ggggacctgg tggatgctga     3300

ggagtatctg gtaccccagc agggcttctt ctgtccagac cctgccccgg gcgctggggg     3360

catggtccac cacaggcacc gcagctcatc taccaggagt ggcggtgggg acctgacact     3420

agggctggag ccctctgaag aggaggcccc caggtctcca ctggcaccct ccgaaggggc     3480

tggctccgat gtatttgatg gtgacctggg aatgggggca gccaaggggc tgcaaagcct     3540

ccccacacat gaccccagcc ctctacagcg gtacagtgag gaccccacag tacccctgcc     3600

ctctgagact gatggctacg ttgcccccct gacctgcagc ccccagcctg aatatgtgaa     3660

ccagccagat gttcggcccc agcccccttc gccccgagag ggccctctgc ctgctgcccg     3720

acctgctggt gccactctgg aaaggcccaa gactctctcc ccagggaaga atggggtcgt     3780

caaagacgtt tttgcctttg ggggtgccgt ggagaacccc gagtacttga caccccaggg     3840

aggagctgcc cctcagcccc accctcctcc tgccttcagc ccagccttcg acaacctcta     3900

ttactgggac caggacccac cagagcgggg ggctccaccc agcaccttca aagggacacc     3960

tacggcagag aacccagagt acctgggtct ggacgtgcca gtgtgaacca gaaggccaag     4020

tccgcagaag ccctgatgtg tcctcaggga gcagggaagg cctgacttct gctggcatca     4080

agaggtggga gggccctccg accacttcca ggggaacctg ccatgccagg aacctgtcct     4140

aaggaacctt ccttcctgct tgagttccca gatggctgga aggggtccag cctcgttgga     4200

agaggaacag cactggggag tctttgtgga ttctgaggcc ctgcccaatg agactctagg     4260

gtccagtgga tgccacagcc cagcttggcc ctttccttcc agatcctggg tactgaaagc     4320

cttagggaag ctggcctgag aggggaagcg gccctaaggg agtgtctaag aacaaaagcg     4380

acccattcag agactgtccc tgaaacctag tactgccccc catgaggaag gaacagcaat     4440

ggtgtcagta tccaggcttt gtacagagtg cttttctgtt tagtttttac tttttttgtt     4500

ttgttttttt aaagatgaaa taaagaccca gggggagaat gggtgttgta tggggaggca     4560

agtgtggggg gtccttctcc acacccactt tgtccatttg caaatatatt ttggaaaaca     4620

gcta                                                                  4624


<210>  5
<211>  1342
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            900                 905                 910         


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        915                 920                 925             


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    930                 935                 940                 


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
945                 950                 955                 960 


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                965                 970                 975     


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            980                 985                 990         


His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 
        995                 1000                 1005             


Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 
    1010                 1015                 1020             


Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 
    1025                 1030                 1035             


Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 
    1040                 1045                 1050             


Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Glu Ser  Cys Gln Glu 
    1055                 1060                 1065             


Ser Ala  Val Ser Gly Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser 
    1070                 1075                 1080             


Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 
    1100                 1105                 1110             


Met Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 
    1115                 1120                 1125             


Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 
    1130                 1135                 1140             


Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 
    1145                 1150                 1155             


Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 
    1160                 1165                 1170             


Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 
    1175                 1180                 1185             


Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 
    1190                 1195                 1200             


Arg Arg  His Ser Pro Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu 
    1205                 1210                 1215             


Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 
    1220                 1225                 1230             


Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Ile 
    1235                 1240                 1245             


Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 
    1250                 1255                 1260             


Asn Arg  Gln Arg Asp Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala 
    1265                 1270                 1275             


Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 
    1280                 1285                 1290             


Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 
    1295                 1300                 1305             


Arg Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 
    1310                 1315                 1320             


Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 
    1325                 1330                 1335             


Ala Gln  Arg Thr 
    1340         


<210>  6
<211>  5765
<212>  DNA
<213>  Homo sapiens

<400>  6
actccagcct cgcgcgggag ggggcgcggc cgtgactcac ccccttccct ctgcgttcct       60

ccctccctct ctctctctct ctcacacaca cacacccctc ccctgccatc cctccccgga      120

ctccggctcc ggctccgatt gcaatttgca acctccgctg ccgtcgccgc agcagccacc      180

aattcgccag cggttcaggt ggctcttgcc tcgatgtcct agcctagggg cccccgggcc      240

ggacttggct gggctccctt caccctctgc ggagtcatga gggcgaacga cgctctgcag      300

gtgctgggct tgcttttcag cctggcccgg ggctccgagg tgggcaactc tcaggcagtg      360

tgtcctggga ctctgaatgg cctgagtgtg accggcgatg ctgagaacca ataccagaca      420

ctgtacaagc tctacgagag gtgtgaggtg gtgatgggga accttgagat tgtgctcacg      480

ggacacaatg ccgacctctc cttcctgcag tggattcgag aagtgacagg ctatgtcctc      540

gtggccatga atgaattctc tactctacca ttgcccaacc tccgcgtggt gcgagggacc      600

caggtctacg atgggaagtt tgccatcttc gtcatgttga actataacac caactccagc      660

cacgctctgc gccagctccg cttgactcag ctcaccgaga ttctgtcagg gggtgtttat      720

attgagaaga acgataagct ttgtcacatg gacacaattg actggaggga catcgtgagg      780

gaccgagatg ctgagatagt ggtgaaggac aatggcagaa gctgtccccc ctgtcatgag      840

gtttgcaagg ggcgatgctg gggtcctgga tcagaagact gccagacatt gaccaagacc      900

atctgtgctc ctcagtgtaa tggtcactgc tttgggccca accccaacca gtgctgccat      960

gatgagtgtg ccgggggctg ctcaggccct caggacacag actgctttgc ctgccggcac     1020

ttcaatgaca gtggagcctg tgtacctcgc tgtccacagc ctcttgtcta caacaagcta     1080

actttccagc tggaacccaa tccccacacc aagtatcagt atggaggagt ttgtgtagcc     1140

agctgtcccc ataactttgt ggtggatcaa acatcctgtg tcagggcctg tcctcctgac     1200

aagatggaag tagataaaaa tgggctcaag atgtgtgagc cttgtggggg actatgtccc     1260

aaagcctgtg agggaacagg ctctgggagc cgcttccaga ctgtggactc gagcaacatt     1320

gatggatttg tgaactgcac caagatcctg ggcaacctgg actttctgat caccggcctc     1380

aatggagacc cctggcacaa gatccctgcc ctggacccag agaagctcaa tgtcttccgg     1440

acagtacggg agatcacagg ttacctgaac atccagtcct ggccgcccca catgcacaac     1500

ttcagtgttt tttccaattt gacaaccatt ggaggcagaa gcctctacaa ccggggcttc     1560

tcattgttga tcatgaagaa cttgaatgtc acatctctgg gcttccgatc cctgaaggaa     1620

attagtgctg ggcgtatcta tataagtgcc aataggcagc tctgctacca ccactctttg     1680

aactggacca aggtgcttcg ggggcctacg gaagagcgac tagacatcaa gcataatcgg     1740

ccgcgcagag actgcgtggc agagggcaaa gtgtgtgacc cactgtgctc ctctggggga     1800

tgctggggcc caggccctgg tcagtgcttg tcctgtcgaa attatagccg aggaggtgtc     1860

tgtgtgaccc actgcaactt tctgaatggg gagcctcgag aatttgccca tgaggccgaa     1920

tgcttctcct gccacccgga atgccaaccc atggagggca ctgccacatg caatggctcg     1980

ggctctgata cttgtgctca atgtgcccat tttcgagatg ggccccactg tgtgagcagc     2040

tgcccccatg gagtcctagg tgccaagggc ccaatctaca agtacccaga tgttcagaat     2100

gaatgtcggc cctgccatga gaactgcacc caggggtgta aaggaccaga gcttcaagac     2160

tgtttaggac aaacactggt gctgatcggc aaaacccatc tgacaatggc tttgacagtg     2220

atagcaggat tggtagtgat tttcatgatg ctgggcggca cttttctcta ctggcgtggg     2280

cgccggattc agaataaaag ggctatgagg cgatacttgg aacggggtga gagcatagag     2340

cctctggacc ccagtgagaa ggctaacaaa gtcttggcca gaatcttcaa agagacagag     2400

ctaaggaagc ttaaagtgct tggctcgggt gtctttggaa ctgtgcacaa aggagtgtgg     2460

atccctgagg gtgaatcaat caagattcca gtctgcatta aagtcattga ggacaagagt     2520

ggacggcaga gttttcaagc tgtgacagat catatgctgg ccattggcag cctggaccat     2580

gcccacattg taaggctgct gggactatgc ccagggtcat ctctgcagct tgtcactcaa     2640

tatttgcctc tgggttctct gctggatcat gtgagacaac accggggggc actggggcca     2700

cagctgctgc tcaactgggg agtacaaatt gccaagggaa tgtactacct tgaggaacat     2760

ggtatggtgc atagaaacct ggctgcccga aacgtgctac tcaagtcacc cagtcaggtt     2820

caggtggcag attttggtgt ggctgacctg ctgcctcctg atgataagca gctgctatac     2880

agtgaggcca agactccaat taagtggatg gcccttgaga gtatccactt tgggaaatac     2940

acacaccaga gtgatgtctg gagctatggt gtgacagttt gggagttgat gaccttcggg     3000

gcagagccct atgcagggct acgattggct gaagtaccag acctgctaga gaagggggag     3060

cggttggcac agccccagat ctgcacaatt gatgtctaca tggtgatggt caagtgttgg     3120

atgattgatg agaacattcg cccaaccttt aaagaactag ccaatgagtt caccaggatg     3180

gcccgagacc caccacggta tctggtcata aagagagaga gtgggcctgg aatagcccct     3240

gggccagagc cccatggtct gacaaacaag aagctagagg aagtagagct ggagccagaa     3300

ctagacctag acctagactt ggaagcagag gaggacaacc tggcaaccac cacactgggc     3360

tccgccctca gcctaccagt tggaacactt aatcggccac gtgggagcca gagcctttta     3420

agtccatcat ctggatacat gcccatgaac cagggtaatc ttggggagtc ttgccaggag     3480

tctgcagttt ctgggagcag tgaacggtgc ccccgtccag tctctctaca cccaatgcca     3540

cggggatgcc tggcatcaga gtcatcagag gggcatgtaa caggctctga ggctgagctc     3600

caggagaaag tgtcaatgtg taggagccgg agcaggagcc ggagcccacg gccacgcgga     3660

gatagcgcct accattccca gcgccacagt ctgctgactc ctgttacccc actctcccca     3720

cccgggttag aggaagagga tgtcaacggt tatgtcatgc cagatacaca cctcaaaggt     3780

actccctcct cccgggaagg caccctttct tcagtgggtc tcagttctgt cctgggtact     3840

gaagaagaag atgaagatga ggagtatgaa tacatgaacc ggaggagaag gcacagtcca     3900

cctcatcccc ctaggccaag ttcccttgag gagctgggtt atgagtacat ggatgtgggg     3960

tcagacctca gtgcctctct gggcagcaca cagagttgcc cactccaccc tgtacccatc     4020

atgcccactg caggcacaac tccagatgaa gactatgaat atatgaatcg gcaacgagat     4080

ggaggtggtc ctgggggtga ttatgcagcc atgggggcct gcccagcatc tgagcaaggg     4140

tatgaagaga tgagagcttt tcaggggcct ggacatcagg ccccccatgt ccattatgcc     4200

cgcctaaaaa ctctacgtag cttagaggct acagactctg cctttgataa ccctgattac     4260

tggcatagca ggcttttccc caaggctaat gcccagagaa cgtaactcct gctccctgtg     4320

gcactcaggg agcatttaat ggcagctagt gcctttagag ggtaccgtct tctccctatt     4380

ccctctctct cccaggtccc agcccctttt ccccagtccc agacaattcc attcaatctt     4440

tggaggcttt taaacatttt gacacaaaat tcttatggta tgtagccagc tgtgcacttt     4500

cttctctttc ccaaccccag gaaaggtttt ccttattttg tgtgctttcc cagtcccatt     4560

cctcagcttc ttcacaggca ctcctggaga tatgaaggat tactctccat atcccttcct     4620

ctcaggctct tgactacttg gaactaggct cttatgtgtg cctttgtttc ccatcagact     4680

gtcaagaaga ggaaagggag gaaacctagc agaggaaagt gtaattttgg tttatgactc     4740

ttaaccccct agaaagacag aagcttaaaa tctgtgaaga aagaggttag gagtagatat     4800

tgattactat cataattcag cacttaacta tgagccaggc atcatactaa acttcaccta     4860

cattatctca cttagtcctt tatcatcctt aaaacaattc tgtgacatac atattatctc     4920

attttacaca aagggaagtc gggcatggtg gctcatgcct gtaatctcag cactttggga     4980

ggctgaggca gaaggattac ctgaggcaag gagtttgaga ccagcttagc caacatagta     5040

agacccccat ctctttaaaa aaaaaaaaaa aaaaaaaaaa aaaactttag aactgggtgc     5100

agtggctcat gcctgtaatc ccagccagca ctttgggagg ctgagatggg aagatcactt     5160

gagcccagaa ttagagataa gcctatggaa acatagcaag acactgtctc tacaggggaa     5220

aaaaaaaaaa gaaactgagc cttaaagaga tgaaataaat taagcagtag atccaggatg     5280

caaaatcctc ccaattcctg tgcatgtgct cttattgtaa ggtgccaaga aaaactgatt     5340

taagttacag cccttgttta aggggcactg tttcttgttt ttgcactgaa tcaagtctaa     5400

ccccaacagc cacatcctcc tatacctaga catctcatct caggaagtgg tggtgggggt     5460

agtcagaagg aaaaataact ggacatcttt gtgtaaacca taatccacat gtgccgtaaa     5520

tgatcttcac tccttatccg agggcaaatt cacaaggatc cccaagatcc acttttagaa     5580

gccattctca tccagcagtg agaagcttcc aggtaggaca gaaaaaagat ccagcttcag     5640

ctgcacacct ctgtcccctt ggatggggaa ctaagggaaa acgtctgttg tatcactgaa     5700

gttttttgtt ttgtttttat acgtgtctga ataaaaatgc caaagttttt tttcagcaaa     5760

aaaaa                                                                 5765


<210>  7
<211>  1282
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala 
1               5                   10                  15      


Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr 
            20                  25                  30          


Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala 
        35                  40                  45              


Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr 
                85                  90                  95      


Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu 
            100                 105                 110         


Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn 
        115                 120                 125             


Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn 
    130                 135                 140                 


Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr 
145                 150                 155                 160 


Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr 
                165                 170                 175     


Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser 
            180                 185                 190         


Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu 
        195                 200                 205             


Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro 
    210                 215                 220                 


Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly 
225                 230                 235                 240 


Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly 
                245                 250                 255     


Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr 
            260                 265                 270         


Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe 
        275                 280                 285             


Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys 
    290                 295                 300                 


Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile 
305                 310                 315                 320 


Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly 
                325                 330                 335     


Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn 
            340                 345                 350         


Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe 
        355                 360                 365             


Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile 
    370                 375                 380                 


Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val 
                405                 410                 415     


Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu 
            420                 425                 430         


Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln 
        435                 440                 445             


Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser 
    450                 455                 460                 


Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr 
465                 470                 475                 480 


Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys 
                485                 490                 495     


Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys 
            500                 505                 510         


Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg 
        515                 520                 525             


Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg 
    530                 535                 540                 


Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu 
545                 550                 555                 560 


Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn 
                565                 570                 575     


Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys 
            580                 585                 590         


Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala 
        595                 600                 605             


Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly 
    610                 615                 620                 


Cys Ile Gly Ser Ser Ile Glu Asp Cys Ile Gly Leu Met Asp Arg Thr 
625                 630                 635                 640 


Pro Leu Ile Ala Ala Gly Val Ile Gly Gly Leu Phe Ile Leu Val Ile 
                645                 650                 655     


Val Gly Leu Thr Phe Ala Val Tyr Val Arg Arg Lys Ser Ile Lys Lys 
            660                 665                 670         


Lys Arg Ala Leu Arg Arg Phe Leu Glu Thr Glu Leu Val Glu Pro Leu 
        675                 680                 685             


Thr Pro Ser Gly Thr Ala Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys 
    690                 695                 700                 


Glu Thr Glu Leu Lys Arg Val Lys Val Leu Gly Ser Gly Ala Phe Gly 
705                 710                 715                 720 


Thr Val Tyr Lys Gly Ile Trp Val Pro Glu Gly Glu Thr Val Lys Ile 
                725                 730                 735     


Pro Val Ala Ile Lys Ile Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn 
            740                 745                 750         


Val Glu Phe Met Asp Glu Ala Leu Ile Met Ala Ser Met Asp His Pro 
        755                 760                 765             


His Leu Val Arg Leu Leu Gly Val Cys Leu Ser Pro Thr Ile Gln Leu 
    770                 775                 780                 


Val Thr Gln Leu Met Pro His Gly Cys Leu Leu Glu Tyr Val His Glu 
785                 790                 795                 800 


His Lys Asp Asn Ile Gly Ser Gln Leu Leu Leu Asn Trp Cys Val Gln 
                805                 810                 815     


Ile Ala Lys Gly Met Met Tyr Leu Glu Glu Arg Arg Leu Val His Arg 
            820                 825                 830         


Asp Leu Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys 
        835                 840                 845             


Ile Thr Asp Phe Gly Leu Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu 
    850                 855                 860                 


Tyr Asn Ala Asp Gly Gly Lys Met Pro Ile Lys Trp Met Ala Leu Glu 
865                 870                 875                 880 


Cys Ile His Tyr Arg Lys Phe Thr His Gln Ser Asp Val Trp Ser Tyr 
                885                 890                 895     


Gly Val Thr Ile Trp Glu Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp 
            900                 905                 910         


Gly Ile Pro Thr Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg 
        915                 920                 925             


Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Val Met Val 
    930                 935                 940                 


Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu 
945                 950                 955                 960 


Ala Ala Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Tyr Leu Val 
                965                 970                 975     


Ile Gln Gly Asp Asp Arg Met Lys Leu Pro Ser Pro Asn Asp Ser Lys 
            980                 985                 990         


Phe Phe Gln Asn Leu Leu Asp Glu  Glu Asp Leu Glu Asp  Met Met Asp 
        995                 1000                 1005             


Ala Glu  Glu Tyr Leu Val Pro  Gln Ala Phe Asn Ile  Pro Pro Pro 
    1010                 1015                 1020             


Ile Tyr  Thr Ser Arg Ala Arg  Ile Asp Ser Asn Arg  Asn Gln Phe 
    1025                 1030                 1035             


Val Tyr  Arg Asp Gly Gly Phe  Ala Ala Glu Gln Gly  Val Ser Val 
    1040                 1045                 1050             


Pro Tyr  Arg Ala Pro Thr Ser  Thr Ile Pro Glu Ala  Pro Val Ala 
    1055                 1060                 1065             


Gln Gly  Ala Thr Ala Glu Ile  Phe Asp Asp Ser Cys  Cys Asn Gly 
    1070                 1075                 1080             


Thr Leu  Arg Lys Pro Val Ala  Pro His Val Gln Glu  Asp Ser Ser 
    1085                 1090                 1095             


Thr Gln  Arg Tyr Ser Ala Asp  Pro Thr Val Phe Ala  Pro Glu Arg 
    1100                 1105                 1110             


Ser Pro  Arg Gly Glu Leu Asp  Glu Glu Gly Tyr Met  Thr Pro Met 
    1115                 1120                 1125             


Arg Asp  Lys Pro Lys Gln Glu  Tyr Leu Asn Pro Val  Glu Glu Asn 
    1130                 1135                 1140             


Pro Phe  Val Ser Arg Arg Lys  Asn Gly Asp Leu Gln  Ala Leu Asp 
    1145                 1150                 1155             


Asn Pro  Glu Tyr His Asn Ala  Ser Asn Gly Pro Pro  Lys Ala Glu 
    1160                 1165                 1170             


Asp Glu  Tyr Val Asn Glu Pro  Leu Tyr Leu Asn Thr  Phe Ala Asn 
    1175                 1180                 1185             


Thr Leu  Gly Lys Ala Glu Tyr  Leu Lys Asn Asn Ile  Leu Ser Met 
    1190                 1195                 1200             


Pro Glu  Lys Ala Lys Lys Ala  Phe Asp Asn Pro Asp  Tyr Trp Asn 
    1205                 1210                 1215             


His Ser  Leu Pro Pro Arg Ser  Thr Leu Gln His Pro  Asp Tyr Leu 
    1220                 1225                 1230             


Gln Glu  Tyr Ser Thr Lys Tyr  Phe Tyr Lys Gln Asn  Gly Arg Ile 
    1235                 1240                 1245             


Arg Pro  Ile Val Ala Glu Asn  Pro Glu Tyr Leu Ser  Glu Phe Ser 
    1250                 1255                 1260             


Leu Lys  Pro Gly Thr Val Leu  Pro Pro Pro Pro Tyr  Arg His Arg 
    1265                 1270                 1275             


Asn Thr  Val Val 
    1280         


<210>  8
<211>  3931
<212>  DNA
<213>  Homo sapiens

<400>  8
cagcacggga tctgagactt ccaaaaaatg aagccggcga caggactttg ggtctgggtg       60

agccttctcg tggcggcggg gaccgtccag cccagcgatt ctcagtcagt gtgtgcagga      120

acggagaata aactgagctc tctctctgac ctggaacagc agtaccgagc cttgcgcaag      180

tactatgaaa actgtgaggt tgtcatgggc aacctggaga taaccagcat tgagcacaac      240

cgggacctct ccttcctgcg gtctgttcga gaagtcacag gctacgtgtt agtggctctt      300

aatcagtttc gttacctgcc tctggagaat ttacgcatta ttcgtgggac aaaactttat      360

gaggatcgat atgccttggc aatattttta aactacagaa aagatggaaa ctttggactt      420

caagaacttg gattaaagaa cttgacagaa atcctaaatg gtggagtcta tgtagaccag      480

aacaaattcc tttgttatgc agacaccatt cattggcaag atattgttcg gaacccatgg      540

ccttccaact tgactcttgt gtcaacaaat ggtagttcag gatgtggacg ttgccataag      600

tcctgtactg gccgttgctg gggacccaca gaaaatcatt gccagacttt gacaaggacg      660

gtgtgtgcag aacaatgtga cggcagatgc tacggacctt acgtcagtga ctgctgccat      720

cgagaatgtg ctggaggctg ctcaggacct aaggacacag actgctttgc ctgcatgaat      780

ttcaatgaca gtggagcatg tgttactcag tgtccccaaa cctttgtcta caatccaacc      840

acctttcaac tggagcacaa tttcaatgca aagtacacat atggagcatt ctgtgtcaag      900

aaatgtccac ataactttgt ggtagattcc agttcttgtg tgcgtgcctg ccctagttcc      960

aagatggaag tagaagaaaa tgggattaaa atgtgtaaac cttgcactga catttgccca     1020

aaagcttgtg atggcattgg cacaggatca ttgatgtcag ctcagactgt ggattccagt     1080

aacattgaca aattcataaa ctgtaccaag atcaatggga atttgatctt tctagtcact     1140

ggtattcatg gggaccctta caatgcaatt gaagccatag acccagagaa actgaacgtc     1200

tttcggacag tcagagagat aacaggtttc ctgaacatac agtcatggcc accaaacatg     1260

actgacttca gtgttttttc taacctggtg accattggtg gaagagtact ctatagtggc     1320

ctgtccttgc ttatcctcaa gcaacagggc atcacctctc tacagttcca gtccctgaag     1380

gaaatcagcg caggaaacat ctatattact gacaacagca acctgtgtta ttatcatacc     1440

attaactgga caacactctt cagcacaatc aaccagagaa tagtaatccg ggacaacaga     1500

aaagctgaaa attgtactgc tgaaggaatg gtgtgcaacc atctgtgttc cagtgatggc     1560

tgttggggac ctgggccaga ccaatgtctg tcgtgtcgcc gcttcagtag aggaaggatc     1620

tgcatagagt cttgtaacct ctatgatggt gaatttcggg agtttgagaa tggctccatc     1680

tgtgtggagt gtgaccccca gtgtgagaag atggaagatg gcctcctcac atgccatgga     1740

ccgggtcctg acaactgtac aaagtgctct cattttaaag atggcccaaa ctgtgtggaa     1800

aaatgtccag atggcttaca gggggcaaac agtttcattt tcaagtatgc tgatccagat     1860

cgggagtgcc acccatgcca tccaaactgc acccaagggt gcataggctc aagtattgaa     1920

gactgcatcg gcctgatgga tagaactccc ctgattgcag ctggagtaat tggtgggctc     1980

ttcattctgg tcattgtggg tctgacattt gctgtttatg ttagaaggaa gagcatcaaa     2040

aagaaaagag ccttgagaag attcttggaa acagagttgg tggaaccatt aactcccagt     2100

ggcacagcac ccaatcaagc tcaacttcgt attttgaaag aaactgagct gaagagggta     2160

aaagtccttg gctcaggtgc ttttggaacg gtttataaag gtatttgggt acctgaagga     2220

gaaactgtga agattcctgt ggctattaag attcttaatg agacaactgg tcccaaggca     2280

aatgtggagt tcatggatga agctctgatc atggcaagta tggatcatcc acacctagtc     2340

cggttgctgg gtgtgtgtct gagcccaacc atccagctgg ttactcaact tatgccccat     2400

ggctgcctgt tggagtatgt ccacgagcac aaggataaca ttggatcaca actgctgctt     2460

aactggtgtg tccagatagc taagggaatg atgtacctgg aagaaagacg actcgttcat     2520

cgggatttgg cagcccgtaa tgtcttagtg aaatctccaa accatgtgaa aatcacagat     2580

tttgggctag ccagactctt ggaaggagat gaaaaagagt acaatgctga tggaggaaag     2640

atgccaatta aatggatggc tctggagtgt atacattaca ggaaattcac ccatcagagt     2700

gacgtttgga gctatggagt tactatatgg gaactgatga cctttggagg aaaaccctat     2760

gatggaattc caacgcgaga aatccctgat ttattagaga aaggagaacg tttgcctcag     2820

cctcccatct gcactattga cgtttacatg gtcatggtca aatgttggat gattgatgct     2880

gacagtagac ctaaatttaa ggaactggct gctgagtttt caaggatggc tcgagaccct     2940

caaagatacc tagttattca gggtgatgat cgtatgaagc ttcccagtcc aaatgacagc     3000

aagttctttc agaatctctt ggatgaagag gatttggaag atatgatgga tgctgaggag     3060

tacttggtcc ctcaggcttt caacatccca cctcccatct atacttccag agcaagaatt     3120

gactcgaata ggaaccagtt tgtgtaccga gatggaggtt ttgctgctga acaaggagtg     3180

tctgtgccct acagagcccc aactagcaca attccagaag ctcctgtggc acagggtgct     3240

actgctgaga tttttgatga ctcctgctgt aatggcaccc tacgcaagcc agtggcaccc     3300

catgtccaag aggacagtag cacccagagg tacagtgctg accccaccgt gtttgcccca     3360

gaacggagcc cacgaggaga gctggatgag gaaggttaca tgactcctat gcgagacaaa     3420

cccaaacaag aatacctgaa tccagtggag gagaaccctt ttgtttctcg gagaaaaaat     3480

ggagaccttc aagcattgga taatcccgaa tatcacaatg catccaatgg tccacccaag     3540

gccgaggatg agtatgtgaa tgagccactg tacctcaaca cctttgccaa caccttggga     3600

aaagctgagt acctgaagaa caacatactg tcaatgccag agaaggccaa gaaagcgttt     3660

gacaaccctg actactggaa ccacagcctg ccacctcgga gcacccttca gcacccagac     3720

tacctgcagg agtacagcac aaaatatttt tataaacaga atgggcggat ccggcctatt     3780

gtggcagaga atcctgaata cctctctgag ttctccctga agccaggcac tgtgctgccg     3840

cctccacctt acagacaccg gaatactgtg gtgtaagctc agttgtggtt ttttaggtgg     3900

agagacacac ctgctccaat ttccccaccc c                                    3931


<210>  9
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             


Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 


Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 


Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     


Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         


Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             


Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 
    210                 215                 220                 


Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 
225                 230                 235                 240 


Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 
                245                 250                 255     


Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 
            260                 265                 270         


Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
        275                 280                 285             


Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn 
    290                 295                 300                 


Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
305                 310                 315                 320 


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
                325                 330                 335     


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
            340                 345                 350         


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
        355                 360                 365             


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
    370                 375                 380                 


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 
385                 390                 395                 400 


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
                405                 410                 415     


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
            420                 425                 430         


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
        435                 440                 445             


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
    450                 455                 460                 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
465                 470                 475                 480 


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
                485                 490                 495     


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
            500                 505                 510         


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
        515                 520                 525             


Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu 
    530                 535                 540                 


Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 
545                 550                 555                 560 


Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 
                565                 570                 575     


His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 
            580                 585                 590         


Ala Thr Val 
        595 


<210>  10
<211>  6330
<212>  DNA
<213>  Homo sapiens

<400>  10
aggagctggc ggagggcgtt cgtcctggga ctgcacttgc tcccgtcggg tcgcccggct       60

tcaccggacc cgcaggctcc cggggcaggg ccggggccag agctcgcgtg tcggcgggac      120

atgcgctgcg tcgcctctaa cctcgggctg tgctcttttt ccaggtggcc cgccggtttc      180

tgagccttct gccctgcggg gacacggtct gcaccctgcc cgcggccacg gaccatgacc      240

atgaccctcc acaccaaagc atctgggatg gccctactgc atcagatcca agggaacgag      300

ctggagcccc tgaaccgtcc gcagctcaag atccccctgg agcggcccct gggcgaggtg      360

tacctggaca gcagcaagcc cgccgtgtac aactaccccg agggcgccgc ctacgagttc      420

aacgccgcgg ccgccgccaa cgcgcaggtc tacggtcaga ccggcctccc ctacggcccc      480

gggtctgagg ctgcggcgtt cggctccaac ggcctggggg gtttcccccc actcaacagc      540

gtgtctccga gcccgctgat gctactgcac ccgccgccgc agctgtcgcc tttcctgcag      600

ccccacggcc agcaggtgcc ctactacctg gagaacgagc ccagcggcta cacggtgcgc      660

gaggccggcc cgccggcatt ctacaggcca aattcagata atcgacgcca gggtggcaga      720

gaaagattgg ccagtaccaa tgacaaggga agtatggcta tggaatctgc caaggagact      780

cgctactgtg cagtgtgcaa tgactatgct tcaggctacc attatggagt ctggtcctgt      840

gagggctgca aggccttctt caagagaagt attcaaggac ataacgacta tatgtgtcca      900

gccaccaacc agtgcaccat tgataaaaac aggaggaaga gctgccaggc ctgccggctc      960

cgcaaatgct acgaagtggg aatgatgaaa ggtgggatac gaaaagaccg aagaggaggg     1020

agaatgttga aacacaagcg ccagagagat gatggggagg gcaggggtga agtggggtct     1080

gctggagaca tgagagctgc caacctttgg ccaagcccgc tcatgatcaa acgctctaag     1140

aagaacagcc tggccttgtc cctgacggcc gaccagatgg tcagtgcctt gttggatgct     1200

gagcccccca tactctattc cgagtatgat cctaccagac ccttcagtga agcttcgatg     1260

atgggcttac tgaccaacct ggcagacagg gagctggttc acatgatcaa ctgggcgaag     1320

agggtgccag gctttgtgga tttgaccctc catgatcagg tccaccttct agaatgtgcc     1380

tggctagaga tcctgatgat tggtctcgtc tggcgctcca tggagcaccc agggaagcta     1440

ctgtttgctc ctaacttgct cttggacagg aaccagggaa aatgtgtaga gggcatggtg     1500

gagatcttcg acatgctgct ggctacatca tctcggttcc gcatgatgaa tctgcaggga     1560

gaggagtttg tgtgcctcaa atctattatt ttgcttaatt ctggagtgta cacatttctg     1620

tccagcaccc tgaagtctct ggaagagaag gaccatatcc accgagtcct ggacaagatc     1680

acagacactt tgatccacct gatggccaag gcaggcctga ccctgcagca gcagcaccag     1740

cggctggccc agctcctcct catcctctcc cacatcaggc acatgagtaa caaaggcatg     1800

gagcatctgt acagcatgaa gtgcaagaac gtggtgcccc tctatgacct gctgctggag     1860

atgctggacg cccaccgcct acatgcgccc actagccgtg gaggggcatc cgtggaggag     1920

acggaccaaa gccacttggc cactgcgggc tctacttcat cgcattcctt gcaaaagtat     1980

tacatcacgg gggaggcaga gggtttccct gccacggtct gagagctccc tggctcccac     2040

acggttcaga taatccctgc tgcattttac cctcatcatg caccacttta gccaaattct     2100

gtctcctgca tacactccgg catgcatcca acaccaatgg ctttctagat gagtggccat     2160

tcatttgctt gctcagttct tagtggcaca tcttctgtct tctgttggga acagccaaag     2220

ggattccaag gctaaatctt tgtaacagct ctctttcccc cttgctatgt tactaagcgt     2280

gaggattccc gtagctcttc acagctgaac tcagtctatg ggttggggct cagataactc     2340

tgtgcattta agctacttgt agagacccag gcctggagag tagacatttt gcctctgata     2400

agcacttttt aaatggctct aagaataagc cacagcaaag aatttaaagt ggctccttta     2460

attggtgact tggagaaagc taggtcaagg gtttattata gcaccctctt gtattcctat     2520

ggcaatgcat ccttttatga aagtggtaca ccttaaagct tttatatgac tgtagcagag     2580

tatctggtga ttgtcaattc attcccccta taggaataca aggggcacac agggaaggca     2640

gatcccctag ttggcaagac tattttaact tgatacactg cagattcaga tgtgctgaaa     2700

gctctgcctc tggctttccg gtcatgggtt ccagttaatt catgcctccc atggacctat     2760

ggagagcagc aagttgatct tagttaagtc tccctatatg agggataagt tcctgatttt     2820

tgtttttatt tttgtgttac aaaagaaagc cctccctccc tgaacttgca gtaaggtcag     2880

cttcaggacc tgttccagtg ggcactgtac ttggatcttc ccggcgtgtg tgtgccttac     2940

acaggggtga actgttcact gtggtgatgc atgatgaggg taaatggtag ttgaaaggag     3000

caggggccct ggtgttgcat ttagccctgg ggcatggagc tgaacagtac ttgtgcagga     3060

ttgttgtggc tactagagaa caagagggaa agtagggcag aaactggata cagttctgag     3120

gcacagccag acttgctcag ggtggccctg ccacaggctg cagctaccta ggaacattcc     3180

ttgcagaccc cgcattgccc tttgggggtg ccctgggatc cctggggtag tccagctctt     3240

cttcatttcc cagcgtggcc ctggttggaa gaagcagctg tcacagctgc tgtagacagc     3300

tgtgttccta caattggccc agcaccctgg ggcacgggag aagggtgggg accgttgctg     3360

tcactactca ggctgactgg ggcctggtca gattacgtat gcccttggtg gtttagagat     3420

aatccaaaat cagggtttgg tttggggaag aaaatcctcc cccttcctcc cccgccccgt     3480

tccctaccgc ctccactcct gccagctcat ttccttcaat ttcctttgac ctataggcta     3540

aaaaagaaag gctcattcca gccacagggc agccttccct gggcctttgc ttctctagca     3600

caattatggg ttacttcctt tttcttaaca aaaaagaatg tttgatttcc tctgggtgac     3660

cttattgtct gtaattgaaa ccctattgag aggtgatgtc tgtgttagcc aatgacccag     3720

gtgagctgct cgggcttctc ttggtatgtc ttgtttggaa aagtggattt cattcatttc     3780

tgattgtcca gttaagtgat caccaaagga ctgagaatct gggagggcaa aaaaaaaaaa     3840

aaagttttta tgtgcactta aatttgggga caattttatg tatctgtgtt aaggatatgt     3900

ttaagaacat aattcttttg ttgctgtttg tttaagaagc accttagttt gtttaagaag     3960

caccttatat agtataatat atattttttt gaaattacat tgcttgttta tcagacaatt     4020

gaatgtagta attctgttct ggatttaatt tgactgggtt aacatgcaaa aaccaaggaa     4080

aaatatttag tttttttttt tttttttgta tacttttcaa gctaccttgt catgtataca     4140

gtcatttatg cctaaagcct ggtgattatt catttaaatg aagatcacat ttcatatcaa     4200

cttttgtatc cacagtagac aaaatagcac taatccagat gcctattgtt ggatactgaa     4260

tgacagacaa tcttatgtag caaagattat gcctgaaaag gaaaattatt cagggcagct     4320

aattttgctt ttaccaaaat atcagtagta atatttttgg acagtagcta atgggtcagt     4380

gggttctttt taatgtttat acttagattt tcttttaaaa aaattaaaat aaaacaaaaa     4440

aaaatttcta ggactagacg atgtaatacc agctaaagcc aaacaattat acagtggaag     4500

gttttacatt attcatccaa tgtgtttcta ttcatgttaa gatactacta catttgaagt     4560

gggcagagaa catcagatga ttgaaatgtt cgcccagggg tctccagcaa ctttggaaat     4620

ctctttgtat ttttacttga agtgccacta atggacagca gatattttct ggctgatgtt     4680

ggtattgggt gtaggaacat gatttaaaaa aaaactcttg cctctgcttt cccccactct     4740

gaggcaagtt aaaatgtaaa agatgtgatt tatctggggg gctcaggtat ggtggggaag     4800

tggattcagg aatctgggga atggcaaata tattaagaag agtattgaaa gtatttggag     4860

gaaaatggtt aattctgggt gtgcaccagg gttcagtaga gtccacttct gccctggaga     4920

ccacaaatca actagctcca tttacagcca tttctaaaat ggcagcttca gttctagaga     4980

agaaagaaca acatcagcag taaagtccat ggaatagcta gtggtctgtg tttcttttcg     5040

ccattgccta gcttgccgta atgattctat aatgccatca tgcagcaatt atgagaggct     5100

aggtcatcca aagagaagac cctatcaatg taggttgcaa aatctaaccc ctaaggaagt     5160

gcagtctttg atttgatttc cctagtaacc ttgcagatat gtttaaccaa gccatagccc     5220

atgccttttg agggctgaac aaataaggga cttactgata atttactttt gatcacatta     5280

aggtgttctc accttgaaat cttatacact gaaatggcca ttgatttagg ccactggctt     5340

agagtactcc ttcccctgca tgacactgat tacaaatact ttcctattca tactttccaa     5400

ttatgagatg gactgtgggt actgggagtg atcactaaca ccatagtaat gtctaatatt     5460

cacaggcaga tctgcttggg gaagctagtt atgtgaaagg caaatagagt catacagtag     5520

ctcaaaaggc aaccataatt ctctttggtg caggtcttgg gagcgtgatc tagattacac     5580

tgcaccattc ccaagttaat cccctgaaaa cttactctca actggagcaa atgaactttg     5640

gtcccaaata tccatctttt cagtagcgtt aattatgctc tgtttccaac tgcatttcct     5700

ttccaattga attaaagtgt ggcctcgttt ttagtcattt aaaattgttt tctaagtaat     5760

tgctgcctct attatggcac ttcaattttg cactgtcttt tgagattcaa gaaaaatttc     5820

tattcttttt tttgcatcca attgtgcctg aacttttaaa atatgtaaat gctgccatgt     5880

tccaaaccca tcgtcagtgt gtgtgtttag agctgtgcac cctagaaaca acatattgtc     5940

ccatgagcag gtgcctgaga cacagacccc tttgcattca cagagaggtc attggttata     6000

gagacttgaa ttaataagtg acattatgcc agtttctgtt ctctcacagg tgataaacaa     6060

tgctttttgt gcactacata ctcttcagtg tagagctctt gttttatggg aaaaggctca     6120

aatgccaaat tgtgtttgat ggattaatat gcccttttgc cgatgcatac tattactgat     6180

gtgactcggt tttgtcgcag ctttgctttg tttaatgaaa cacacttgta aacctctttt     6240

gcactttgaa aaagaatcca gcgggatgct cgagcacctg taaacaattt tctcaaccta     6300

tttgatgttc aaataaagaa ttaaactaaa                                      6330


<210>  11
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Thr Glu Leu Lys Ala Lys Gly Pro Arg Ala Pro His Val Ala Gly 
1               5                   10                  15      


Gly Pro Pro Ser Pro Glu Val Gly Ser Pro Leu Leu Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Pro Phe Pro Gly Ser Gln Thr Ser Asp Thr Leu Pro Glu Val 
        35                  40                  45              


Ser Ala Ile Pro Ile Ser Leu Asp Gly Leu Leu Phe Pro Arg Pro Cys 
    50                  55                  60                  


Gln Gly Gln Asp Pro Ser Asp Glu Lys Thr Gln Asp Gln Gln Ser Leu 
65                  70                  75                  80  


Ser Asp Val Glu Gly Ala Tyr Ser Arg Ala Glu Ala Thr Arg Gly Ala 
                85                  90                  95      


Gly Gly Ser Ser Ser Ser Pro Pro Glu Lys Asp Ser Gly Leu Leu Asp 
            100                 105                 110         


Ser Val Leu Asp Thr Leu Leu Ala Pro Ser Gly Pro Gly Gln Ser Gln 
        115                 120                 125             


Pro Ser Pro Pro Ala Cys Glu Val Thr Ser Ser Trp Cys Leu Phe Gly 
    130                 135                 140                 


Pro Glu Leu Pro Glu Asp Pro Pro Ala Ala Pro Ala Thr Gln Arg Val 
145                 150                 155                 160 


Leu Ser Pro Leu Met Ser Arg Ser Gly Cys Lys Val Gly Asp Ser Ser 
                165                 170                 175     


Gly Thr Ala Ala Ala His Lys Val Leu Pro Arg Gly Leu Ser Pro Ala 
            180                 185                 190         


Arg Gln Leu Leu Leu Pro Ala Ser Glu Ser Pro His Trp Ser Gly Ala 
        195                 200                 205             


Pro Val Lys Pro Ser Pro Gln Ala Ala Ala Val Glu Val Glu Glu Glu 
    210                 215                 220                 


Asp Gly Ser Glu Ser Glu Glu Ser Ala Gly Pro Leu Leu Lys Gly Lys 
225                 230                 235                 240 


Pro Arg Ala Leu Gly Gly Ala Ala Ala Gly Gly Gly Ala Ala Ala Val 
                245                 250                 255     


Pro Pro Gly Ala Ala Ala Gly Gly Val Ala Leu Val Pro Lys Glu Asp 
            260                 265                 270         


Ser Arg Phe Ser Ala Pro Arg Val Ala Leu Val Glu Gln Asp Ala Pro 
        275                 280                 285             


Met Ala Pro Gly Arg Ser Pro Leu Ala Thr Thr Val Met Asp Phe Ile 
    290                 295                 300                 


His Val Pro Ile Leu Pro Leu Asn His Ala Leu Leu Ala Ala Arg Thr 
305                 310                 315                 320 


Arg Gln Leu Leu Glu Asp Glu Ser Tyr Asp Gly Gly Ala Gly Ala Ala 
                325                 330                 335     


Ser Ala Phe Ala Pro Pro Arg Ser Ser Pro Cys Ala Ser Ser Thr Pro 
            340                 345                 350         


Val Ala Val Gly Asp Phe Pro Asp Cys Ala Tyr Pro Pro Asp Ala Glu 
        355                 360                 365             


Pro Lys Asp Asp Ala Tyr Pro Leu Tyr Ser Asp Phe Gln Pro Pro Ala 
    370                 375                 380                 


Leu Lys Ile Lys Glu Glu Glu Glu Gly Ala Glu Ala Ser Ala Arg Ser 
385                 390                 395                 400 


Pro Arg Ser Tyr Leu Val Ala Gly Ala Asn Pro Ala Ala Phe Pro Asp 
                405                 410                 415     


Phe Pro Leu Gly Pro Pro Pro Pro Leu Pro Pro Arg Ala Thr Pro Ser 
            420                 425                 430         


Arg Pro Gly Glu Ala Ala Val Thr Ala Ala Pro Ala Ser Ala Ser Val 
        435                 440                 445             


Ser Ser Ala Ser Ser Ser Gly Ser Thr Leu Glu Cys Ile Leu Tyr Lys 
    450                 455                 460                 


Ala Glu Gly Ala Pro Pro Gln Gln Gly Pro Phe Ala Pro Pro Pro Cys 
465                 470                 475                 480 


Lys Ala Pro Gly Ala Ser Gly Cys Leu Leu Pro Arg Asp Gly Leu Pro 
                485                 490                 495     


Ser Thr Ser Ala Ser Ala Ala Ala Ala Gly Ala Ala Pro Ala Leu Tyr 
            500                 505                 510         


Pro Ala Leu Gly Leu Asn Gly Leu Pro Gln Leu Gly Tyr Gln Ala Ala 
        515                 520                 525             


Val Leu Lys Glu Gly Leu Pro Gln Val Tyr Pro Pro Tyr Leu Asn Tyr 
    530                 535                 540                 


Leu Arg Pro Asp Ser Glu Ala Ser Gln Ser Pro Gln Tyr Ser Phe Glu 
545                 550                 555                 560 


Ser Leu Pro Gln Lys Ile Cys Leu Ile Cys Gly Asp Glu Ala Ser Gly 
                565                 570                 575     


Cys His Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys 
            580                 585                 590         


Arg Ala Met Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp 
        595                 600                 605             


Cys Ile Val Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Leu 
    610                 615                 620                 


Arg Lys Cys Cys Gln Ala Gly Met Val Leu Gly Gly Arg Lys Phe Lys 
625                 630                 635                 640 


Lys Phe Asn Lys Val Arg Val Val Arg Ala Leu Asp Ala Val Ala Leu 
                645                 650                 655     


Pro Gln Pro Leu Gly Val Pro Asn Glu Ser Gln Ala Leu Ser Gln Arg 
            660                 665                 670         


Phe Thr Phe Ser Pro Gly Gln Asp Ile Gln Leu Ile Pro Pro Leu Ile 
        675                 680                 685             


Asn Leu Leu Met Ser Ile Glu Pro Asp Val Ile Tyr Ala Gly His Asp 
    690                 695                 700                 


Asn Thr Lys Pro Asp Thr Ser Ser Ser Leu Leu Thr Ser Leu Asn Gln 
705                 710                 715                 720 


Leu Gly Glu Arg Gln Leu Leu Ser Val Val Lys Trp Ser Lys Ser Leu 
                725                 730                 735     


Pro Gly Phe Arg Asn Leu His Ile Asp Asp Gln Ile Thr Leu Ile Gln 
            740                 745                 750         


Tyr Ser Trp Met Ser Leu Met Val Phe Gly Leu Gly Trp Arg Ser Tyr 
        755                 760                 765             


Lys His Val Ser Gly Gln Met Leu Tyr Phe Ala Pro Asp Leu Ile Leu 
    770                 775                 780                 


Asn Glu Gln Arg Met Lys Glu Ser Ser Phe Tyr Ser Leu Cys Leu Thr 
785                 790                 795                 800 


Met Trp Gln Ile Pro Gln Glu Phe Val Lys Leu Gln Val Ser Gln Glu 
                805                 810                 815     


Glu Phe Leu Cys Met Lys Val Leu Leu Leu Leu Asn Thr Ile Pro Leu 
            820                 825                 830         


Glu Gly Leu Arg Ser Gln Thr Gln Phe Glu Glu Met Arg Ser Ser Tyr 
        835                 840                 845             


Ile Arg Glu Leu Ile Lys Ala Ile Gly Leu Arg Gln Lys Gly Val Val 
    850                 855                 860                 


Ser Ser Ser Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Asn Leu 
865                 870                 875                 880 


His Asp Leu Val Lys Gln Leu His Leu Tyr Cys Leu Asn Thr Phe Ile 
                885                 890                 895     


Gln Ser Arg Ala Leu Ser Val Glu Phe Pro Glu Met Met Ser Glu Val 
            900                 905                 910         


Ile Ala Ala Gln Leu Pro Lys Ile Leu Ala Gly Met Val Lys Pro Leu 
        915                 920                 925             


Leu Phe His Lys Lys 
    930             


<210>  12
<211>  3014
<212>  DNA
<213>  Homo sapiens

<400>  12
ctgaccagcg ccgccctccc ccgcccccga cccaggaggt ggagatccct ccggtccagc       60

cacattcaac acccactttc tcctccctct gcccctatat tcccgaaacc ccctcctcct      120

tcccttttcc ctcctccctg gagacggggg aggagaaaag gggagtccag tcgtcatgac      180

tgagctgaag gcaaagggtc cccgggctcc ccacgtggcg ggcggcccgc cctcccccga      240

ggtcggatcc ccactgctgt gtcgcccagc cgcaggtccg ttcccgggga gccagacctc      300

ggacaccttg cctgaagttt cggccatacc tatctccctg gacgggctac tcttccctcg      360

gccctgccag ggacaggacc cctccgacga aaagacgcag gaccagcagt cgctgtcgga      420

cgtggagggc gcatattcca gagctgaagc tacaaggggt gctggaggca gcagttctag      480

tcccccagaa aaggacagcg gactgctgga cagtgtcttg gacactctgt tggcgccctc      540

aggtcccggg cagagccaac ccagccctcc cgcctgcgag gtcaccagct cttggtgcct      600

gtttggcccc gaacttcccg aagatccacc ggctgccccc gccacccagc gggtgttgtc      660

cccgctcatg agccggtccg ggtgcaaggt tggagacagc tccgggacgg cagctgccca      720

taaagtgctg ccccggggcc tgtcaccagc ccggcagctg ctgctcccgg cctctgagag      780

ccctcactgg tccggggccc cagtgaagcc gtctccgcag gccgctgcgg tggaggttga      840

ggaggaggat ggctctgagt ccgaggagtc tgcgggtccg cttctgaagg gcaaacctcg      900

ggctctgggt ggcgcggcgg ctggaggagg agccgcggct gtcccgccgg gggcggcagc      960

aggaggcgtc gccctggtcc ccaaggaaga ttcccgcttc tcagcgccca gggtcgccct     1020

ggtggagcag gacgcgccga tggcgcccgg gcgctccccg ctggccacca cggtgatgga     1080

tttcatccac gtgcctatcc tgcctctcaa tcacgcctta ttggcagccc gcactcggca     1140

gctgctggaa gacgaaagtt acgacggcgg ggccggggct gccagcgcct ttgccccgcc     1200

gcggagttca ccctgtgcct cgtccacccc ggtcgctgta ggcgacttcc ccgactgcgc     1260

gtacccgccc gacgccgagc ccaaggacga cgcgtaccct ctctatagcg acttccagcc     1320

gcccgctcta aagataaagg aggaggagga aggcgcggag gcctccgcgc gctccccgcg     1380

ttcctacctt gtggccggtg ccaaccccgc agccttcccg gatttcccgt tggggccacc     1440

gcccccgctg ccgccgcgag cgaccccatc cagacccggg gaagcggcgg tgacggccgc     1500

acccgccagt gcctcagtct cgtctgcgtc ctcctcgggg tcgaccctgg agtgcatcct     1560

gtacaaagcg gagggcgcgc cgccccagca gggcccgttc gcgccgccgc cctgcaaggc     1620

gccgggcgcg agcggctgcc tgctcccgcg ggacggcctg ccctccacct ccgcctctgc     1680

cgccgccgcc ggggcggccc ccgcgctcta ccctgcactc ggcctcaacg ggctcccgca     1740

gctcggctac caggccgccg tgctcaagga gggcctgccg caggtctacc cgccctatct     1800

caactacctg aggccggatt cagaagccag ccagagccca caatacagct tcgagtcatt     1860

acctcagaag atttgtttaa tctgtgggga tgaagcatca ggctgtcatt atggtgtcct     1920

tacctgtggg agctgtaagg tcttctttaa gagggcaatg gaagggcagc acaactactt     1980

atgtgctgga agaaatgact gcatcgttga taaaatccgc agaaaaaact gcccagcatg     2040

tcgccttaga aagtgctgtc aggctggcat ggtccttgga ggtcgaaaat ttaaaaagtt     2100

caataaagtc agagttgtga gagcactgga tgctgttgct ctcccacagc cattgggcgt     2160

tccaaatgaa agccaagccc taagccagag attcactttt tcaccaggtc aagacataca     2220

gttgattcca ccactgatca acctgttaat gagcattgaa ccagatgtga tctatgcagg     2280

acatgacaac acaaaacctg acacctccag ttctttgctg acaagtctta atcaactagg     2340

cgagaggcaa cttctttcag tagtcaagtg gtctaaatca ttgccaggtt ttcgaaactt     2400

acatattgat gaccagataa ctctcattca gtattcttgg atgagcttaa tggtgtttgg     2460

tctaggatgg agatcctaca aacatgtcag tgggcagatg ctgtattttg cacctgatct     2520

aatactaaat gaacagcgga tgaaagaatc atcattctat tcattatgcc ttaccatgtg     2580

gcagatccca caggagtttg tcaagcttca agttagccaa gaagagttcc tctgtatgaa     2640

agtattgtta cttcttaata caattccttt ggaagggcta cgaagtcaaa cccagtttga     2700

ggagatgagg tcaagctaca ttagagagct catcaaggca attggtttga ggcaaaaagg     2760

agttgtgtcg agctcacagc gtttctatca acttacaaaa cttcttgata acttgcatga     2820

tcttgtcaaa caacttcatc tgtactgctt gaatacattt atccagtccc gggcactgag     2880

tgttgaattt ccagaaatga tgtctgaagt tattgctgca caattaccca agatattggc     2940

agggatggtg aaaccccttc tctttcataa aaagtgaatg tcatcttttt cttttaaaga     3000

attaaatttt gtgg                                                       3014


