                         SEQUENCE LISTING

<110>  UNIVERSITE DE GENEVE
       UNIVERSITT ZRICH
 
<120>  NEW USES OF NOGO-A INHIBITORS AND RELATED METHODS

<130>  P1307PC00

<150>  61/362,876
<151>  2010-07-09

<160>  43    

<170>  PatentIn version 3.3

<210>  1
<211>  1192
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Asp Leu Asp Gln Ser Pro Leu Val Ser Ser Ser Asp Ser Pro 
1               5                   10                  15      


Pro Arg Pro Gln Pro Ala Phe Lys Tyr Gln Phe Val Arg Glu Pro Glu 
            20                  25                  30          


Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Asp 
        35                  40                  45              


Leu Glu Glu Leu Glu Val Leu Glu Arg Lys Pro Ala Ala Gly Leu Ser 
    50                  55                  60                  


Ala Ala Pro Val Pro Thr Ala Pro Ala Ala Gly Ala Pro Leu Met Asp 
65                  70                  75                  80  


Phe Gly Asn Asp Phe Val Pro Pro Ala Pro Arg Gly Pro Leu Pro Ala 
                85                  90                  95      


Ala Pro Pro Val Ala Pro Glu Arg Gln Pro Ser Trp Asp Pro Ser Pro 
            100                 105                 110         


Val Ser Ser Thr Val Pro Ala Pro Ser Pro Leu Ser Ala Ala Ala Val 
        115                 120                 125             


Ser Pro Ser Lys Leu Pro Glu Asp Asp Glu Pro Pro Ala Arg Pro Pro 
    130                 135                 140                 


Pro Pro Pro Pro Ala Ser Val Ser Pro Gln Ala Glu Pro Val Trp Thr 
145                 150                 155                 160 


Pro Pro Ala Pro Ala Pro Ala Ala Pro Pro Ser Thr Pro Ala Ala Pro 
                165                 170                 175     


Lys Arg Arg Gly Ser Ser Gly Ser Val Asp Glu Thr Leu Phe Ala Leu 
            180                 185                 190         


Pro Ala Ala Ser Glu Pro Val Ile Arg Ser Ser Ala Glu Asn Met Asp 
        195                 200                 205             


Leu Lys Glu Gln Pro Gly Asn Thr Ile Ser Ala Gly Gln Glu Asp Phe 
    210                 215                 220                 


Pro Ser Val Leu Leu Glu Thr Ala Ala Ser Leu Pro Ser Leu Ser Pro 
225                 230                 235                 240 


Leu Ser Ala Ala Ser Phe Lys Glu His Glu Tyr Leu Gly Asn Leu Ser 
                245                 250                 255     


Thr Val Leu Pro Thr Glu Gly Thr Leu Gln Glu Asn Val Ser Glu Ala 
            260                 265                 270         


Ser Lys Glu Val Ser Glu Lys Ala Lys Thr Leu Leu Ile Asp Arg Asp 
        275                 280                 285             


Leu Thr Glu Phe Ser Glu Leu Glu Tyr Ser Glu Met Gly Ser Ser Phe 
    290                 295                 300                 


Ser Val Ser Pro Lys Ala Glu Ser Ala Val Ile Val Ala Asn Pro Arg 
305                 310                 315                 320 


Glu Glu Ile Ile Val Lys Asn Lys Asp Glu Glu Glu Lys Leu Val Ser 
                325                 330                 335     


Asn Asn Ile Leu His Asn Gln Gln Glu Leu Pro Thr Ala Leu Thr Lys 
            340                 345                 350         


Leu Val Lys Glu Asp Glu Val Val Ser Ser Glu Lys Ala Lys Asp Ser 
        355                 360                 365             


Phe Asn Glu Lys Arg Val Ala Val Glu Ala Pro Met Arg Glu Glu Tyr 
    370                 375                 380                 


Ala Asp Phe Lys Pro Phe Glu Arg Val Trp Glu Val Lys Asp Ser Lys 
385                 390                 395                 400 


Glu Asp Ser Asp Met Leu Ala Ala Gly Gly Lys Ile Glu Ser Asn Leu 
                405                 410                 415     


Glu Ser Lys Val Asp Lys Lys Cys Phe Ala Asp Ser Leu Glu Gln Thr 
            420                 425                 430         


Asn His Glu Lys Asp Ser Glu Ser Ser Asn Asp Asp Thr Ser Phe Pro 
        435                 440                 445             


Ser Thr Pro Glu Gly Ile Lys Asp Arg Ser Gly Ala Tyr Ile Thr Cys 
    450                 455                 460                 


Ala Pro Phe Asn Pro Ala Ala Thr Glu Ser Ile Ala Thr Asn Ile Phe 
465                 470                 475                 480 


Pro Leu Leu Gly Asp Pro Thr Ser Glu Asn Lys Thr Asp Glu Lys Lys 
                485                 490                 495     


Ile Glu Glu Lys Lys Ala Gln Ile Val Thr Glu Lys Asn Thr Ser Thr 
            500                 505                 510         


Lys Thr Ser Asn Pro Phe Leu Val Ala Ala Gln Asp Ser Glu Thr Asp 
        515                 520                 525             


Tyr Val Thr Thr Asp Asn Leu Thr Lys Val Thr Glu Glu Val Val Ala 
    530                 535                 540                 


Asn Met Pro Glu Gly Leu Thr Pro Asp Leu Val Gln Glu Ala Cys Glu 
545                 550                 555                 560 


Ser Glu Leu Asn Glu Val Thr Gly Thr Lys Ile Ala Tyr Glu Thr Lys 
                565                 570                 575     


Met Asp Leu Val Gln Thr Ser Glu Val Met Gln Glu Ser Leu Tyr Pro 
            580                 585                 590         


Ala Ala Gln Leu Cys Pro Ser Phe Glu Glu Ser Glu Ala Thr Pro Ser 
        595                 600                 605             


Pro Val Leu Pro Asp Ile Val Met Glu Ala Pro Leu Asn Ser Ala Val 
    610                 615                 620                 


Pro Ser Ala Gly Ala Ser Val Ile Gln Pro Ser Ser Ser Pro Leu Glu 
625                 630                 635                 640 


Ala Ser Ser Val Asn Tyr Glu Ser Ile Lys His Glu Pro Glu Asn Pro 
                645                 650                 655     


Pro Pro Tyr Glu Glu Ala Met Ser Val Ser Leu Lys Lys Val Ser Gly 
            660                 665                 670         


Ile Lys Glu Glu Ile Lys Glu Pro Glu Asn Ile Asn Ala Ala Leu Gln 
        675                 680                 685             


Glu Thr Glu Ala Pro Tyr Ile Ser Ile Ala Cys Asp Leu Ile Lys Glu 
    690                 695                 700                 


Thr Lys Leu Ser Ala Glu Pro Ala Pro Asp Phe Ser Asp Tyr Ser Glu 
705                 710                 715                 720 


Met Ala Lys Val Glu Gln Pro Val Pro Asp His Ser Glu Leu Val Glu 
                725                 730                 735     


Asp Ser Ser Pro Asp Ser Glu Pro Val Asp Leu Phe Ser Asp Asp Ser 
            740                 745                 750         


Ile Pro Asp Val Pro Gln Lys Gln Asp Glu Thr Val Met Leu Val Lys 
        755                 760                 765             


Glu Ser Leu Thr Glu Thr Ser Phe Glu Ser Met Ile Glu Tyr Glu Asn 
    770                 775                 780                 


Lys Glu Lys Leu Ser Ala Leu Pro Pro Glu Gly Gly Lys Pro Tyr Leu 
785                 790                 795                 800 


Glu Ser Phe Lys Leu Ser Leu Asp Asn Thr Lys Asp Thr Leu Leu Pro 
                805                 810                 815     


Asp Glu Val Ser Thr Leu Ser Lys Lys Glu Lys Ile Pro Leu Gln Met 
            820                 825                 830         


Glu Glu Leu Ser Thr Ala Val Tyr Ser Asn Asp Asp Leu Phe Ile Ser 
        835                 840                 845             


Lys Glu Ala Gln Ile Arg Glu Thr Glu Thr Phe Ser Asp Ser Ser Pro 
    850                 855                 860                 


Ile Glu Ile Ile Asp Glu Phe Pro Thr Leu Ile Ser Ser Lys Thr Asp 
865                 870                 875                 880 


Ser Phe Ser Lys Leu Ala Arg Glu Tyr Thr Asp Leu Glu Val Ser His 
                885                 890                 895     


Lys Ser Glu Ile Ala Asn Ala Pro Asp Gly Ala Gly Ser Leu Pro Cys 
            900                 905                 910         


Thr Glu Leu Pro His Asp Leu Ser Leu Lys Asn Ile Gln Pro Lys Val 
        915                 920                 925             


Glu Glu Lys Ile Ser Phe Ser Asp Asp Phe Ser Lys Asn Gly Ser Ala 
    930                 935                 940                 


Thr Ser Lys Val Leu Leu Leu Pro Pro Asp Val Ser Ala Leu Ala Thr 
945                 950                 955                 960 


Gln Ala Glu Ile Glu Ser Ile Val Lys Pro Lys Val Leu Val Lys Glu 
                965                 970                 975     


Ala Glu Lys Lys Leu Pro Ser Asp Thr Glu Lys Glu Asp Arg Ser Pro 
            980                 985                 990         


Ser Ala Ile Phe Ser Ala Glu Leu  Ser Lys Thr Ser Val  Val Asp Leu 
        995                 1000                 1005             


Leu Tyr  Trp Arg Asp Ile Lys  Lys Thr Gly Val Val  Phe Gly Ala 
    1010                 1015                 1020             


Ser Leu  Phe Leu Leu Leu Ser  Leu Thr Val Phe Ser  Ile Val Ser 
    1025                 1030                 1035             


Val Thr  Ala Tyr Ile Ala Leu  Ala Leu Leu Ser Val  Thr Ile Ser 
    1040                 1045                 1050             


Phe Arg  Ile Tyr Lys Gly Val  Ile Gln Ala Ile Gln  Lys Ser Asp 
    1055                 1060                 1065             


Glu Gly  His Pro Phe Arg Ala  Tyr Leu Glu Ser Glu  Val Ala Ile 
    1070                 1075                 1080             


Ser Glu  Glu Leu Val Gln Lys  Tyr Ser Asn Ser Ala  Leu Gly His 
    1085                 1090                 1095             


Val Asn  Cys Thr Ile Lys Glu  Leu Arg Arg Leu Phe  Leu Val Asp 
    1100                 1105                 1110             


Asp Leu  Val Asp Ser Leu Lys  Phe Ala Val Leu Met  Trp Val Phe 
    1115                 1120                 1125             


Thr Tyr  Val Gly Ala Leu Phe  Asn Gly Leu Thr Leu  Leu Ile Leu 
    1130                 1135                 1140             


Ala Leu  Ile Ser Leu Phe Ser  Val Pro Val Ile Tyr  Glu Arg His 
    1145                 1150                 1155             


Gln Ala  Gln Ile Asp His Tyr  Leu Gly Leu Ala Asn  Lys Asn Val 
    1160                 1165                 1170             


Lys Asp  Ala Met Ala Lys Ile  Gln Ala Lys Ile Pro  Gly Leu Lys 
    1175                 1180                 1185             


Arg Lys  Ala Glu 
    1190         


<210>  2
<211>  3579
<212>  DNA
<213>  Homo sapiens

<400>  2
atggaagacc tggaccagtc tcctctggtc tcgtcctcgg acagcccacc ccggccgcag     60

cccgcgttca agtaccagtt cgtgagggag cccgaggacg aggaggaaga agaggaggag    120

gaagaggagg acgaggacga agacctggag gagctggagg tgctggagag gaagcccgcc    180

gccgggctgt ccgcggcccc agtgcccacc gcccctgccg ccggcgcgcc cctgatggac    240

ttcggaaatg acttcgtgcc gccggcgccc cggggacccc tgccggccgc tccccccgtc    300

gccccggagc ggcagccgtc ttgggacccg agcccggtgt cgtcgaccgt gcccgcgcca    360

tccccgctgt ctgctgccgc agtctcgccc tccaagctcc ctgaggacga cgagcctccg    420

gcccggcctc cccctcctcc cccggccagc gtgagccccc aggcagagcc cgtgtggacc    480

ccgccagccc cggctcccgc cgcgcccccc tccaccccgg ccgcgcccaa gcgcaggggc    540

tcctcgggct cagtggatga gacccttttt gctcttcctg ctgcatctga gcctgtgata    600

cgctcctctg cagaaaatat ggacttgaag gagcagccag gtaacactat ttcggctggt    660

caagaggatt tcccatctgt cctgcttgaa actgctgctt ctcttccttc tctgtctcct    720

ctctcagccg cttctttcaa agaacatgaa taccttggta atttgtcaac agtattaccc    780

actgaaggaa cacttcaaga aaatgtcagt gaagcttcta aagaggtctc agagaaggca    840

aaaactctac tcatagatag agatttaaca gagttttcag aattagaata ctcagaaatg    900

ggatcatcgt tcagtgtctc tccaaaagca gaatctgccg taatagtagc aaatcctagg    960

gaagaaataa tcgtgaaaaa taaagatgaa gaagagaagt tagttagtaa taacatcctt   1020

cataatcaac aagagttacc tacagctctt actaaattgg ttaaagagga tgaagttgtg   1080

tcttcagaaa aagcaaaaga cagttttaat gaaaagagag ttgcagtgga agctcctatg   1140

agggaggaat atgcagactt caaaccattt gagcgagtat gggaagtgaa agatagtaag   1200

gaagatagtg atatgttggc tgctggaggt aaaatcgaga gcaacttgga aagtaaagtg   1260

gataaaaaat gttttgcaga tagccttgag caaactaatc acgaaaaaga tagtgagagt   1320

agtaatgatg atacttcttt ccccagtacg ccagaaggta taaaggatcg tccaggagca   1380

tatatcacat gtgctccctt taacccagca gcaactgaga gcattgcaac aaacattttt   1440

cctttgttag gagatcctac ttcagaaaat aagaccgatg aaaaaaaaat agaagaaaag   1500

aaggcccaaa tagtaacaga gaagaatact agcaccaaaa catcaaaccc ttttcttgta   1560

gcagcacagg attctgagac agattatgtc acaacagata atttaacaaa ggtgactgag   1620

gaagtcgtgg caaacatgcc tgaaggcctg actccagatt tagtacagga agcatgtgaa   1680

agtgaattga atgaagttac tggtacaaag attgcttatg aaacaaaaat ggacttggtt   1740

caaacatcag aagttatgca agagtcactc tatcctgcag cacagctttg cccatcattt   1800

gaagagtcag aagctactcc ttcaccagtt ttgcctgaca ttgttatgga agcaccattg   1860

aattctgcag ttcctagtgc tggtgcttcc gtgatacagc ccagctcatc accattagaa   1920

gcttcttcag ttaattatga aagcataaaa catgagcctg aaaacccccc accatatgaa   1980

gaggccatga gtgtatcact aaaaaaagta tcaggaataa aggaagaaat taaagagcct   2040

gaaaatatta atgcagctct tcaagaaaca gaagctcctt atatatctat tgcatgtgat   2100

ttaattaaag aaacaaagct ttctgctgaa ccagctccgg atttctctga ttattcagaa   2160

atggcaaaag ttgaacagcc agtgcctgat cattctgagc tagttgaaga ttcctcacct   2220

gattctgaac cagttgactt atttagtgat gattcaatac ctgacgttcc acaaaaacaa   2280

gatgaaactg tgatgcttgt gaaagaaagt ctcactgaga cttcatttga gtcaatgata   2340

gaatatgaaa ataaggaaaa actcagtgct ttgccacctg agggaggaaa gccatatttg   2400

gaatctttta agctcagttt agataacaca aaagataccc tgttacctga tgaagtttca   2460

acattgagca aaaaggagaa aattcctttg cagatggagg agctcagtac tgcagtttat   2520

tcaaatgatg acttatttat ttctaaggaa gcacagataa gagaaactga aacgttttca   2580

gattcatctc caattgaaat tatagatgag ttccctacat tgatcagttc taaaactgat   2640

tcattttcta aattagccag ggaatatact gacctagaag tatcccacaa aagtgaaatt   2700

gctaatgccc cggatggagc tgggtcattg ccttgcacag aattgcccca tgacctttct   2760

ttgaagaaca tacaacccaa agttgaagag aaaatcagtt tctcagatga cttttctaaa   2820

aatgggtctg ctacatcaaa ggtgctctta ttgcctccag atgtttctgc tttggccact   2880

caagcagaga tagagagcat agttaaaccc aaagttcttg tgaaagaagc tgagaaaaaa   2940

cttccttccg atacagaaaa agaggacaga tcaccatctg ctatattttc agcagagctg   3000

agtaaaactt cagttgttga cctcctgtac tggagagaca ttaagaagac tggagtggtg   3060

tttggtgcca gcctattcct gctgctttca ttgacagtat tcagcattgt gagcgtaaca   3120

gcctacattg ccttggccct gctctctgtg accatcagct ttaggatata caagggtgtg   3180

atccaagcta tccagaaatc agatgaaggc cacccattca gggcatatct ggaatctgaa   3240

gttgctatat ctgaggagtt ggttcagaag tacagtaatt ctgctcttgg tcatgtgaac   3300

tgcacgataa aggaactcag gcgcctcttc ttagttgatg atttagttga ttctctgaag   3360

tttgcagtgt tgatgtgggt atttacctat gttggtgcct tgtttaatgg tctgacacta   3420

ctgattttgg ctctcatttc actcttcagt gttcctgtta tttatgaacg gcatcaggcg   3480

cagatagatc attatctagg acttgcaaat aagaatgtta aagatgctat ggctaaaatc   3540

caagcaaaaa tccctggatt gaagcgcaaa gctgaatga                          3579


<210>  3
<211>  131
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fragment 1-131 Human Nogo-A

<400>  3

Met Glu Asp Leu Asp Gln Ser Pro Leu Val Ser Ser Ser Asp Ser Pro 
1               5                   10                  15      


Pro Arg Pro Gln Pro Ala Phe Lys Tyr Gln Phe Val Arg Glu Pro Glu 
            20                  25                  30          


Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Asp 
        35                  40                  45              


Leu Glu Glu Leu Glu Val Leu Glu Arg Lys Pro Ala Ala Gly Leu Ser 
    50                  55                  60                  


Ala Ala Pro Val Pro Thr Ala Pro Ala Ala Gly Ala Pro Leu Met Asp 
65                  70                  75                  80  


Phe Gly Asn Asp Phe Val Pro Pro Ala Pro Arg Gly Pro Leu Pro Ala 
                85                  90                  95      


Ala Pro Pro Val Ala Pro Glu Arg Gln Pro Ser Trp Asp Pro Ser Pro 
            100                 105                 110         


Val Ser Ser Thr Val Pro Ala Pro Ser Pro Leu Ser Ala Ala Ala Val 
        115                 120                 125             


Ser Pro Ser 
    130     


<210>  4
<211>  808
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fragment 132-939 Human Nogo-A

<400>  4

Lys Leu Pro Glu Asp Asp Glu Pro Pro Ala Arg Pro Pro Pro Pro Pro 
1               5                   10                  15      


Pro Ala Ser Val Ser Pro Gln Ala Glu Pro Val Trp Thr Pro Pro Ala 
            20                  25                  30          


Pro Ala Pro Ala Ala Pro Pro Ser Thr Pro Ala Ala Pro Lys Arg Arg 
        35                  40                  45              


Gly Ser Ser Gly Ser Val Asp Glu Thr Leu Phe Ala Leu Pro Ala Ala 
    50                  55                  60                  


Ser Glu Pro Val Ile Arg Ser Ser Ala Glu Asn Met Asp Leu Lys Glu 
65                  70                  75                  80  


Gln Pro Gly Asn Thr Ile Ser Ala Gly Gln Glu Asp Phe Pro Ser Val 
                85                  90                  95      


Leu Leu Glu Thr Ala Ala Ser Leu Pro Ser Leu Ser Pro Leu Ser Ala 
            100                 105                 110         


Ala Ser Phe Lys Glu His Glu Tyr Leu Gly Asn Leu Ser Thr Val Leu 
        115                 120                 125             


Pro Thr Glu Gly Thr Leu Gln Glu Asn Val Ser Glu Ala Ser Lys Glu 
    130                 135                 140                 


Val Ser Glu Lys Ala Lys Thr Leu Leu Ile Asp Arg Asp Leu Thr Glu 
145                 150                 155                 160 


Phe Ser Glu Leu Glu Tyr Ser Glu Met Gly Ser Ser Phe Ser Val Ser 
                165                 170                 175     


Pro Lys Ala Glu Ser Ala Val Ile Val Ala Asn Pro Arg Glu Glu Ile 
            180                 185                 190         


Ile Val Lys Asn Lys Asp Glu Glu Glu Lys Leu Val Ser Asn Asn Ile 
        195                 200                 205             


Leu His Asn Gln Gln Glu Leu Pro Thr Ala Leu Thr Lys Leu Val Lys 
    210                 215                 220                 


Glu Asp Glu Val Val Ser Ser Glu Lys Ala Lys Asp Ser Phe Asn Glu 
225                 230                 235                 240 


Lys Arg Val Ala Val Glu Ala Pro Met Arg Glu Glu Tyr Ala Asp Phe 
                245                 250                 255     


Lys Pro Phe Glu Arg Val Trp Glu Val Lys Asp Ser Lys Glu Asp Ser 
            260                 265                 270         


Asp Met Leu Ala Ala Gly Gly Lys Ile Glu Ser Asn Leu Glu Ser Lys 
        275                 280                 285             


Val Asp Lys Lys Cys Phe Ala Asp Ser Leu Glu Gln Thr Asn His Glu 
    290                 295                 300                 


Lys Asp Ser Glu Ser Ser Asn Asp Asp Thr Ser Phe Pro Ser Thr Pro 
305                 310                 315                 320 


Glu Gly Ile Lys Asp Arg Ser Gly Ala Tyr Ile Thr Cys Ala Pro Phe 
                325                 330                 335     


Asn Pro Ala Ala Thr Glu Ser Ile Ala Thr Asn Ile Phe Pro Leu Leu 
            340                 345                 350         


Gly Asp Pro Thr Ser Glu Asn Lys Thr Asp Glu Lys Lys Ile Glu Glu 
        355                 360                 365             


Lys Lys Ala Gln Ile Val Thr Glu Lys Asn Thr Ser Thr Lys Thr Ser 
    370                 375                 380                 


Asn Pro Phe Leu Val Ala Ala Gln Asp Ser Glu Thr Asp Tyr Val Thr 
385                 390                 395                 400 


Thr Asp Asn Leu Thr Lys Val Thr Glu Glu Val Val Ala Asn Met Pro 
                405                 410                 415     


Glu Gly Leu Thr Pro Asp Leu Val Gln Glu Ala Cys Glu Ser Glu Leu 
            420                 425                 430         


Asn Glu Val Thr Gly Thr Lys Ile Ala Tyr Glu Thr Lys Met Asp Leu 
        435                 440                 445             


Val Gln Thr Ser Glu Val Met Gln Glu Ser Leu Tyr Pro Ala Ala Gln 
    450                 455                 460                 


Leu Cys Pro Ser Phe Glu Glu Ser Glu Ala Thr Pro Ser Pro Val Leu 
465                 470                 475                 480 


Pro Asp Ile Val Met Glu Ala Pro Leu Asn Ser Ala Val Pro Ser Ala 
                485                 490                 495     


Gly Ala Ser Val Ile Gln Pro Ser Ser Ser Pro Leu Glu Ala Ser Ser 
            500                 505                 510         


Val Asn Tyr Glu Ser Ile Lys His Glu Pro Glu Asn Pro Pro Pro Tyr 
        515                 520                 525             


Glu Glu Ala Met Ser Val Ser Leu Lys Lys Val Ser Gly Ile Lys Glu 
    530                 535                 540                 


Glu Ile Lys Glu Pro Glu Asn Ile Asn Ala Ala Leu Gln Glu Thr Glu 
545                 550                 555                 560 


Ala Pro Tyr Ile Ser Ile Ala Cys Asp Leu Ile Lys Glu Thr Lys Leu 
                565                 570                 575     


Ser Ala Glu Pro Ala Pro Asp Phe Ser Asp Tyr Ser Glu Met Ala Lys 
            580                 585                 590         


Val Glu Gln Pro Val Pro Asp His Ser Glu Leu Val Glu Asp Ser Ser 
        595                 600                 605             


Pro Asp Ser Glu Pro Val Asp Leu Phe Ser Asp Asp Ser Ile Pro Asp 
    610                 615                 620                 


Val Pro Gln Lys Gln Asp Glu Thr Val Met Leu Val Lys Glu Ser Leu 
625                 630                 635                 640 


Thr Glu Thr Ser Phe Glu Ser Met Ile Glu Tyr Glu Asn Lys Glu Lys 
                645                 650                 655     


Leu Ser Ala Leu Pro Pro Glu Gly Gly Lys Pro Tyr Leu Glu Ser Phe 
            660                 665                 670         


Lys Leu Ser Leu Asp Asn Thr Lys Asp Thr Leu Leu Pro Asp Glu Val 
        675                 680                 685             


Ser Thr Leu Ser Lys Lys Glu Lys Ile Pro Leu Gln Met Glu Glu Leu 
    690                 695                 700                 


Ser Thr Ala Val Tyr Ser Asn Asp Asp Leu Phe Ile Ser Lys Glu Ala 
705                 710                 715                 720 


Gln Ile Arg Glu Thr Glu Thr Phe Ser Asp Ser Ser Pro Ile Glu Ile 
                725                 730                 735     


Ile Asp Glu Phe Pro Thr Leu Ile Ser Ser Lys Thr Asp Ser Phe Ser 
            740                 745                 750         


Lys Leu Ala Arg Glu Tyr Thr Asp Leu Glu Val Ser His Lys Ser Glu 
        755                 760                 765             


Ile Ala Asn Ala Pro Asp Gly Ala Gly Ser Leu Pro Cys Thr Glu Leu 
    770                 775                 780                 


Pro His Asp Leu Ser Leu Lys Asn Ile Gln Pro Lys Val Glu Glu Lys 
785                 790                 795                 800 


Ile Ser Phe Ser Asp Asp Phe Ser 
                805             


<210>  5
<211>  296
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fragment 206-501 Human Nogo-A

<400>  5

Asn Met Asp Leu Lys Glu Gln Pro Gly Asn Thr Ile Ser Ala Gly Gln 
1               5                   10                  15      


Glu Asp Phe Pro Ser Val Leu Leu Glu Thr Ala Ala Ser Leu Pro Ser 
            20                  25                  30          


Leu Ser Pro Leu Ser Ala Ala Ser Phe Lys Glu His Glu Tyr Leu Gly 
        35                  40                  45              


Asn Leu Ser Thr Val Leu Pro Thr Glu Gly Thr Leu Gln Glu Asn Val 
    50                  55                  60                  


Ser Glu Ala Ser Lys Glu Val Ser Glu Lys Ala Lys Thr Leu Leu Ile 
65                  70                  75                  80  


Asp Arg Asp Leu Thr Glu Phe Ser Glu Leu Glu Tyr Ser Glu Met Gly 
                85                  90                  95      


Ser Ser Phe Ser Val Ser Pro Lys Ala Glu Ser Ala Val Ile Val Ala 
            100                 105                 110         


Asn Pro Arg Glu Glu Ile Ile Val Lys Asn Lys Asp Glu Glu Glu Lys 
        115                 120                 125             


Leu Val Ser Asn Asn Ile Leu His Asn Gln Gln Glu Leu Pro Thr Ala 
    130                 135                 140                 


Leu Thr Lys Leu Val Lys Glu Asp Glu Val Val Ser Ser Glu Lys Ala 
145                 150                 155                 160 


Lys Asp Ser Phe Asn Glu Lys Arg Val Ala Val Glu Ala Pro Met Arg 
                165                 170                 175     


Glu Glu Tyr Ala Asp Phe Lys Pro Phe Glu Arg Val Trp Glu Val Lys 
            180                 185                 190         


Asp Ser Lys Glu Asp Ser Asp Met Leu Ala Ala Gly Gly Lys Ile Glu 
        195                 200                 205             


Ser Asn Leu Glu Ser Lys Val Asp Lys Lys Cys Phe Ala Asp Ser Leu 
    210                 215                 220                 


Glu Gln Thr Asn His Glu Lys Asp Ser Glu Ser Ser Asn Asp Asp Thr 
225                 230                 235                 240 


Ser Phe Pro Ser Thr Pro Glu Gly Ile Lys Asp Arg Ser Gly Ala Tyr 
                245                 250                 255     


Ile Thr Cys Ala Pro Phe Asn Pro Ala Ala Thr Glu Ser Ile Ala Thr 
            260                 265                 270         


Asn Ile Phe Pro Leu Leu Gly Asp Pro Thr Ser Glu Asn Lys Thr Asp 
        275                 280                 285             


Glu Lys Lys Ile Glu Glu Lys Lys 
    290                 295     


<210>  6
<211>  180
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fragment 501-680 Human Nogo-A

<400>  6

Lys Ala Gln Ile Val Thr Glu Lys Asn Thr Ser Thr Lys Thr Ser Asn 
1               5                   10                  15      


Pro Phe Leu Val Ala Ala Gln Asp Ser Glu Thr Asp Tyr Val Thr Thr 
            20                  25                  30          


Asp Asn Leu Thr Lys Val Thr Glu Glu Val Val Ala Asn Met Pro Glu 
        35                  40                  45              


Gly Leu Thr Pro Asp Leu Val Gln Glu Ala Cys Glu Ser Glu Leu Asn 
    50                  55                  60                  


Glu Val Thr Gly Thr Lys Ile Ala Tyr Glu Thr Lys Met Asp Leu Val 
65                  70                  75                  80  


Gln Thr Ser Glu Val Met Gln Glu Ser Leu Tyr Pro Ala Ala Gln Leu 
                85                  90                  95      


Cys Pro Ser Phe Glu Glu Ser Glu Ala Thr Pro Ser Pro Val Leu Pro 
            100                 105                 110         


Asp Ile Val Met Glu Ala Pro Leu Asn Ser Ala Val Pro Ser Ala Gly 
        115                 120                 125             


Ala Ser Val Ile Gln Pro Ser Ser Ser Pro Leu Glu Ala Ser Ser Val 
    130                 135                 140                 


Asn Tyr Glu Ser Ile Lys His Glu Pro Glu Asn Pro Pro Pro Tyr Glu 
145                 150                 155                 160 


Glu Ala Met Ser Val Ser Leu Lys Lys Val Ser Gly Ile Lys Glu Glu 
                165                 170                 175     


Ile Lys Glu Pro 
            180 


<210>  7
<211>  75
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fragment 132-206 Human Nogo-A

<400>  7

Lys Leu Pro Glu Asp Asp Glu Pro Pro Ala Arg Pro Pro Pro Pro Pro 
1               5                   10                  15      


Pro Ala Ser Val Ser Pro Gln Ala Glu Pro Val Trp Thr Pro Pro Ala 
            20                  25                  30          


Pro Ala Pro Ala Ala Pro Pro Ser Thr Pro Ala Ala Pro Lys Arg Arg 
        35                  40                  45              


Gly Ser Ser Gly Ser Val Asp Glu Thr Leu Phe Ala Leu Pro Ala Ala 
    50                  55                  60                  


Ser Glu Pro Val Ile Arg Ser Ser Ala Glu Asn 
65                  70                  75  


<210>  8
<211>  1163
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Met Glu Asp Ile Asp Gln Ser Ser Leu Val Ser Ser Ser Thr Asp Ser 
1               5                   10                  15      


Pro Pro Arg Pro Pro Pro Ala Phe Lys Tyr Gln Phe Val Thr Glu Pro 
            20                  25                  30          


Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Glu Asp Asp 
        35                  40                  45              


Glu Asp Leu Glu Glu Leu Glu Val Leu Glu Arg Lys Pro Ala Ala Gly 
    50                  55                  60                  


Leu Ser Ala Ala Ala Val Pro Pro Ala Ala Ala Ala Pro Leu Leu Asp 
65                  70                  75                  80  


Phe Ser Ser Asp Ser Val Pro Pro Ala Pro Arg Gly Pro Leu Pro Ala 
                85                  90                  95      


Ala Pro Pro Ala Ala Pro Glu Arg Gln Pro Ser Trp Glu Arg Ser Pro 
            100                 105                 110         


Ala Ala Pro Ala Pro Ser Leu Pro Pro Ala Ala Ala Val Leu Pro Ser 
        115                 120                 125             


Lys Leu Pro Glu Asp Asp Glu Pro Pro Ala Arg Pro Pro Pro Pro Pro 
    130                 135                 140                 


Pro Ala Gly Ala Ser Pro Leu Ala Glu Pro Ala Ala Pro Pro Ser Thr 
145                 150                 155                 160 


Pro Ala Ala Pro Lys Arg Arg Gly Ser Gly Ser Val Asp Glu Thr Leu 
                165                 170                 175     


Phe Ala Leu Pro Ala Ala Ser Glu Pro Val Ile Pro Ser Ser Ala Glu 
            180                 185                 190         


Lys Ile Met Asp Leu Met Glu Gln Pro Gly Asn Thr Val Ser Ser Gly 
        195                 200                 205             


Gln Glu Asp Phe Pro Ser Val Leu Leu Glu Thr Ala Ala Ser Leu Pro 
    210                 215                 220                 


Ser Leu Ser Pro Leu Ser Thr Val Ser Phe Lys Glu His Gly Tyr Leu 
225                 230                 235                 240 


Gly Asn Leu Ser Ala Val Ser Ser Ser Glu Gly Thr Ile Glu Glu Thr 
                245                 250                 255     


Leu Asn Glu Ala Ser Lys Glu Leu Pro Glu Arg Ala Thr Asn Pro Phe 
            260                 265                 270         


Val Asn Arg Asp Leu Ala Glu Phe Ser Glu Leu Glu Tyr Ser Glu Met 
        275                 280                 285             


Gly Ser Ser Phe Lys Gly Ser Pro Lys Gly Glu Ser Ala Ile Leu Val 
    290                 295                 300                 


Glu Asn Thr Lys Glu Glu Val Ile Val Arg Ser Lys Asp Lys Glu Asp 
305                 310                 315                 320 


Leu Val Cys Ser Ala Ala Leu His Ser Pro Gln Glu Ser Pro Val Gly 
                325                 330                 335     


Lys Glu Asp Arg Val Val Ser Pro Glu Lys Thr Met Asp Ile Phe Asn 
            340                 345                 350         


Glu Met Gln Met Ser Val Val Ala Pro Val Arg Glu Glu Tyr Ala Asp 
        355                 360                 365             


Phe Lys Pro Phe Glu Gln Ala Trp Glu Val Lys Asp Thr Tyr Glu Gly 
    370                 375                 380                 


Ser Arg Asp Val Leu Ala Ala Arg Ala Asn Val Glu Ser Lys Val Asp 
385                 390                 395                 400 


Arg Lys Cys Leu Glu Asp Ser Leu Glu Gln Lys Ser Leu Gly Lys Asp 
                405                 410                 415     


Ser Glu Gly Arg Asn Glu Asp Ala Ser Phe Pro Ser Thr Pro Glu Pro 
            420                 425                 430         


Val Lys Asp Ser Ser Arg Ala Tyr Ile Thr Cys Ala Ser Phe Thr Ser 
        435                 440                 445             


Ala Thr Glu Ser Thr Thr Ala Asn Thr Phe Pro Leu Leu Glu Asp His 
    450                 455                 460                 


Thr Ser Glu Asn Lys Thr Asp Glu Lys Lys Ile Glu Glu Arg Lys Ala 
465                 470                 475                 480 


Gln Ile Ile Thr Glu Lys Thr Ser Pro Lys Thr Ser Asn Pro Phe Leu 
                485                 490                 495     


Val Ala Val Gln Asp Ser Glu Ala Asp Tyr Val Thr Thr Asp Thr Leu 
            500                 505                 510         


Ser Lys Val Thr Glu Ala Ala Val Ser Asn Met Pro Glu Gly Leu Thr 
        515                 520                 525             


Pro Asp Leu Val Gln Glu Ala Cys Glu Ser Glu Leu Asn Glu Ala Thr 
    530                 535                 540                 


Gly Thr Lys Ile Ala Tyr Glu Thr Lys Val Asp Leu Val Gln Thr Ser 
545                 550                 555                 560 


Glu Ala Ile Gln Glu Ser Leu Tyr Pro Thr Ala Gln Leu Cys Pro Ser 
                565                 570                 575     


Phe Glu Glu Ala Glu Ala Thr Pro Ser Pro Val Leu Pro Asp Ile Val 
            580                 585                 590         


Met Glu Ala Pro Leu Asn Ser Leu Leu Pro Ser Ala Gly Ala Ser Val 
        595                 600                 605             


Val Gln Pro Ser Val Ser Pro Leu Glu Ala Pro Pro Pro Val Ser Tyr 
    610                 615                 620                 


Asp Ser Ile Lys Leu Glu Pro Glu Asn Pro Pro Pro Tyr Glu Glu Ala 
625                 630                 635                 640 


Met Asn Val Ala Leu Lys Ala Leu Gly Thr Lys Glu Gly Ile Lys Glu 
                645                 650                 655     


Pro Glu Ser Phe Asn Ala Ala Val Gln Glu Thr Glu Ala Pro Tyr Ile 
            660                 665                 670         


Ser Ile Ala Cys Asp Leu Ile Lys Glu Thr Lys Leu Ser Thr Glu Pro 
        675                 680                 685             


Ser Pro Asp Phe Ser Asn Tyr Ser Glu Ile Ala Lys Phe Glu Lys Ser 
    690                 695                 700                 


Val Pro Glu His Ala Glu Leu Val Glu Asp Ser Ser Pro Glu Ser Glu 
705                 710                 715                 720 


Pro Val Asp Leu Phe Ser Asp Asp Ser Ile Pro Glu Val Pro Gln Thr 
                725                 730                 735     


Gln Glu Glu Ala Val Met Leu Met Lys Glu Ser Leu Thr Glu Val Ser 
            740                 745                 750         


Glu Thr Val Ala Gln His Lys Glu Glu Arg Leu Ser Ala Ser Pro Gln 
        755                 760                 765             


Glu Leu Gly Lys Pro Tyr Leu Glu Ser Phe Gln Pro Asn Leu His Ser 
    770                 775                 780                 


Thr Lys Asp Ala Ala Ser Asn Asp Ile Pro Thr Leu Thr Lys Lys Glu 
785                 790                 795                 800 


Lys Ile Ser Leu Gln Met Glu Glu Phe Asn Thr Ala Ile Tyr Ser Asn 
                805                 810                 815     


Asp Asp Leu Leu Ser Ser Lys Glu Asp Lys Ile Lys Glu Ser Glu Thr 
            820                 825                 830         


Phe Ser Asp Ser Ser Pro Ile Glu Ile Ile Asp Glu Phe Pro Thr Phe 
        835                 840                 845             


Val Ser Ala Lys Asp Asp Ser Pro Lys Leu Ala Lys Glu Tyr Thr Asp 
    850                 855                 860                 


Leu Glu Val Ser Asp Lys Ser Glu Ile Ala Asn Ile Gln Ser Gly Ala 
865                 870                 875                 880 


Asp Ser Leu Pro Cys Leu Glu Leu Pro Cys Asp Leu Ser Phe Lys Asn 
                885                 890                 895     


Ile Tyr Pro Lys Asp Glu Val His Val Ser Asp Glu Phe Ser Glu Asn 
            900                 905                 910         


Arg Ser Ser Val Ser Lys Ala Ser Ile Ser Pro Ser Asn Val Ser Ala 
        915                 920                 925             


Leu Glu Pro Gln Thr Glu Met Gly Ser Ile Val Lys Ser Lys Ser Leu 
    930                 935                 940                 


Thr Lys Glu Ala Glu Lys Lys Leu Pro Ser Asp Thr Glu Lys Glu Asp 
945                 950                 955                 960 


Arg Ser Leu Ser Ala Val Leu Ser Ala Glu Leu Ser Lys Thr Ser Val 
                965                 970                 975     


Val Asp Leu Leu Tyr Trp Arg Asp Ile Lys Lys Thr Gly Val Val Phe 
            980                 985                 990         


Gly Ala Ser Leu Phe Leu Leu Leu  Ser Leu Thr Val Phe  Ser Ile Val 
        995                 1000                 1005             


Ser Val  Thr Ala Tyr Ile Ala  Leu Ala Leu Leu Ser  Val Thr Ile 
    1010                 1015                 1020             


Ser Phe  Arg Ile Tyr Lys Gly  Val Ile Gln Ala Ile  Gln Lys Ser 
    1025                 1030                 1035             


Asp Glu  Gly His Pro Phe Arg  Ala Tyr Leu Glu Ser  Glu Val Ala 
    1040                 1045                 1050             


Ile Ser  Glu Glu Leu Val Gln  Lys Tyr Ser Asn Ser  Ala Leu Gly 
    1055                 1060                 1065             


His Val  Asn Ser Thr Ile Lys  Glu Leu Arg Arg Leu  Phe Leu Val 
    1070                 1075                 1080             


Asp Asp  Leu Val Asp Ser Leu  Lys Phe Ala Val Leu  Met Trp Val 
    1085                 1090                 1095             


Phe Thr  Tyr Val Gly Ala Leu  Phe Asn Gly Leu Thr  Leu Leu Ile 
    1100                 1105                 1110             


Leu Ala  Leu Ile Ser Leu Phe  Ser Ile Pro Val Ile  Tyr Glu Arg 
    1115                 1120                 1125             


His Gln  Val Gln Ile Asp His  Tyr Leu Gly Leu Ala  Asn Lys Ser 
    1130                 1135                 1140             


Val Lys  Asp Ala Met Ala Lys  Ile Gln Ala Lys Ile  Pro Gly Leu 
    1145                 1150                 1155             


Lys Arg  Lys Ala Asp 
    1160             


<210>  9
<211>  647
<212>  PRT
<213>  Bos taurus

<400>  9

Met Pro Glu Gly Leu Thr Pro Asp Leu Val Gln Glu Ala Cys Glu Ser 
1               5                   10                  15      


Glu Leu Asn Glu Ala Thr Gly Thr Lys Ile Ala Phe Glu Thr Lys Met 
            20                  25                  30          


Asp Leu Val Gln Thr Ser Glu Ala Val Gln Glu Ser Leu Tyr Pro Val 
        35                  40                  45              


Thr Gln Leu Cys Pro Ser Phe Glu Glu Ser Glu Ala Thr Pro Ser Pro 
    50                  55                  60                  


Val Leu Pro Asp Ile Val Met Glu Ala Pro Leu Asn Ser Val Val Pro 
65                  70                  75                  80  


Ser Ala Gly Ala Ser Ala Val Gln Leu Ser Ser Ser Pro Leu Glu Thr 
                85                  90                  95      


Pro Pro Ser Val Asn Tyr Glu Ser Ile Lys Phe Glu Pro Glu Asn Pro 
            100                 105                 110         


Pro Pro Tyr Glu Glu Ala Met Asn Val Ser Leu Lys Lys Glu Ser Gly 
        115                 120                 125             


Met Asn Glu Glu Ile Thr Glu Pro Glu Gly Ile Ser Val Ala Val Gln 
    130                 135                 140                 


Glu Thr Glu Ala Pro Tyr Ile Ser Ile Ala Cys Asp Leu Ile Lys Glu 
145                 150                 155                 160 


Thr Lys Ile Ser Thr Glu Pro Thr Pro Asp Phe Ser Ser Tyr Ser Glu 
                165                 170                 175     


Ile Ala Glu Val Ala Gln Pro Val Pro Glu His Ser Glu Leu Val Glu 
            180                 185                 190         


Asp Ser Ser Pro Asp Ser Glu Pro Val Asp Leu Phe Ser Asp Asp Ser 
        195                 200                 205             


Ile Pro Glu Val Pro Gln Lys Gln Asp Glu Ala Val Ile Leu Val Lys 
    210                 215                 220                 


Glu Asn Leu Thr Glu Ile Ser Ser Glu Ser Met Thr Gly His Asp Asn 
225                 230                 235                 240 


Lys Gly Lys Leu Ser Ala Ser Pro Ser Pro Glu Gly Gly Lys Pro Tyr 
                245                 250                 255     


Leu Glu Ser Phe Gln Pro Ser Leu Gly Ile Thr Lys Asp Thr Leu Ala 
            260                 265                 270         


Pro Asp Glu Val Ser Ala Leu Thr Gln Lys Glu Lys Ile Pro Leu Gln 
        275                 280                 285             


Met Glu Glu Leu Asn Thr Ala Val Tyr Ser Ser Asp Gly Leu Phe Ile 
    290                 295                 300                 


Ala Gln Glu Ala Asn Leu Arg Glu Ser Glu Thr Phe Ser Asp Ser Ser 
305                 310                 315                 320 


Pro Ile Glu Ile Ile Asp Glu Phe Pro Thr Phe Val Ser Ser Lys Ala 
                325                 330                 335     


Asp Ser Ser Pro Thr Leu Ala Arg Glu Tyr Thr Asp Leu Glu Val Ala 
            340                 345                 350         


His Lys Ser Glu Ile Ala Asp Ile Gln Asp Gly Ala Gly Ser Leu Ala 
        355                 360                 365             


Cys Ala Gly Leu Pro His Asp Leu Ser Phe Lys Ser Ile Gln Pro Lys 
    370                 375                 380                 


Glu Glu Val His Val Pro Asp Glu Phe Ser Lys Asp Arg Gly Asp Val 
385                 390                 395                 400 


Ser Lys Val Pro Ile Leu Pro Pro Asp Val Ser Ala Leu Asp Ala Gln 
                405                 410                 415     


Ala Glu Ile Gly Ser Ile Glu Lys Pro Lys Val Leu Val Lys Glu Ala 
            420                 425                 430         


Glu Arg Lys Leu Pro Ser Asp Thr Glu Lys Glu Arg Arg Ser Pro Ser 
        435                 440                 445             


Ala Ile Phe Ser Ala Glu Leu Ser Lys Thr Ser Val Val Asp Leu Leu 
    450                 455                 460                 


Tyr Trp Arg Asp Ile Lys Lys Thr Gly Val Val Phe Gly Ala Ser Leu 
465                 470                 475                 480 


Phe Leu Leu Leu Ser Leu Thr Val Phe Ser Ile Val Ser Val Thr Ala 
                485                 490                 495     


Tyr Ile Ala Leu Ala Leu Leu Ser Val Thr Ile Ser Phe Arg Ile Tyr 
            500                 505                 510         


Lys Gly Val Ile Gln Ala Ile Gln Lys Ser Asp Glu Gly His Pro Phe 
        515                 520                 525             


Arg Ala Tyr Leu Glu Ser Glu Val Ala Ile Ser Glu Glu Leu Val Gln 
    530                 535                 540                 


Lys Tyr Ser Asn Ser Ala Leu Gly His Val Asn Cys Thr Ile Lys Glu 
545                 550                 555                 560 


Leu Arg Arg Leu Phe Leu Val Asp Asp Leu Val Asp Ser Leu Lys Phe 
                565                 570                 575     


Ala Val Leu Met Trp Val Phe Thr Tyr Val Gly Ala Leu Phe Asn Gly 
            580                 585                 590         


Leu Thr Leu Leu Ile Leu Ala Leu Ile Ser Leu Phe Ser Val Pro Val 
        595                 600                 605             


Ile Tyr Glu Arg His Gln Ala Gln Ile Asp His Tyr Leu Gly Leu Ala 
    610                 615                 620                 


Asn Lys Asn Val Lys Asp Ala Met Ala Lys Ile Gln Ala Lys Ile Pro 
625                 630                 635                 640 


Gly Leu Lys Arg Lys Ala Glu 
                645         


<210>  10
<211>  1162
<212>  PRT
<213>  Mus musculus

<400>  10

Met Glu Asp Ile Asp Gln Ser Ser Leu Val Ser Ser Ser Ala Asp Ser 
1               5                   10                  15      


Pro Pro Arg Pro Pro Pro Ala Phe Lys Tyr Gln Phe Val Thr Glu Pro 
            20                  25                  30          


Glu Asp Glu Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Asp Glu 
        35                  40                  45              


Asp Leu Glu Glu Leu Glu Val Leu Glu Arg Lys Pro Ala Ala Gly Leu 
    50                  55                  60                  


Ser Ala Ala Pro Val Pro Pro Ala Ala Ala Pro Leu Leu Asp Phe Ser 
65                  70                  75                  80  


Ser Asp Ser Val Pro Pro Ala Pro Arg Gly Pro Leu Pro Ala Ala Pro 
                85                  90                  95      


Pro Thr Ala Pro Glu Arg Gln Pro Ser Trp Glu Arg Ser Pro Ala Ala 
            100                 105                 110         


Ser Ala Pro Ser Leu Pro Pro Ala Ala Ala Val Leu Pro Ser Lys Leu 
        115                 120                 125             


Pro Glu Asp Asp Glu Pro Pro Ala Arg Pro Pro Ala Pro Ala Gly Ala 
    130                 135                 140                 


Ser Pro Leu Ala Glu Pro Ala Ala Pro Pro Ser Thr Pro Ala Ala Pro 
145                 150                 155                 160 


Lys Arg Arg Gly Ser Gly Ser Val Asp Glu Thr Leu Phe Ala Leu Pro 
                165                 170                 175     


Ala Ala Ser Glu Pro Val Ile Pro Ser Ser Ala Glu Lys Ile Met Asp 
            180                 185                 190         


Leu Lys Glu Gln Pro Gly Asn Thr Val Ser Ser Gly Gln Glu Asp Phe 
        195                 200                 205             


Pro Ser Val Leu Phe Glu Thr Ala Ala Ser Leu Pro Ser Leu Ser Pro 
    210                 215                 220                 


Leu Ser Thr Val Ser Phe Lys Glu His Gly Tyr Leu Gly Asn Leu Ser 
225                 230                 235                 240 


Ala Val Ala Ser Thr Glu Gly Thr Ile Glu Glu Thr Leu Asn Glu Ala 
                245                 250                 255     


Ser Arg Glu Leu Pro Glu Arg Ala Thr Asn Pro Phe Val Asn Arg Glu 
            260                 265                 270         


Ser Ala Glu Phe Ser Val Leu Glu Tyr Ser Glu Met Gly Ser Ser Phe 
        275                 280                 285             


Asn Gly Ser Pro Lys Gly Glu Ser Ala Met Leu Val Glu Asn Thr Lys 
    290                 295                 300                 


Glu Glu Val Ile Val Arg Ser Lys Asp Lys Glu Asp Leu Val Cys Ser 
305                 310                 315                 320 


Ala Ala Leu His Asn Pro Gln Glu Ser Pro Ala Thr Leu Thr Lys Val 
                325                 330                 335     


Val Lys Glu Asp Gly Val Met Ser Pro Glu Lys Thr Met Asp Ile Phe 
            340                 345                 350         


Asn Glu Met Lys Met Ser Val Val Ala Pro Val Arg Glu Glu Tyr Ala 
        355                 360                 365             


Asp Phe Lys Pro Phe Glu Gln Ala Trp Glu Val Lys Asp Thr Tyr Glu 
    370                 375                 380                 


Gly Ser Arg Asp Val Leu Ala Ala Arg Ala Asn Met Glu Ser Lys Val 
385                 390                 395                 400 


Asp Lys Lys Cys Phe Glu Asp Ser Leu Glu Gln Lys Gly His Gly Lys 
                405                 410                 415     


Asp Ser Glu Ser Arg Asn Glu Asn Ala Ser Phe Pro Arg Thr Pro Glu 
            420                 425                 430         


Leu Val Lys Asp Gly Ser Arg Ala Tyr Ile Thr Cys Asp Ser Phe Ser 
        435                 440                 445             


Ser Ala Thr Glu Ser Thr Ala Ala Asn Ile Phe Pro Val Leu Glu Asp 
    450                 455                 460                 


His Thr Ser Glu Asn Lys Thr Asp Glu Lys Lys Ile Glu Glu Arg Lys 
465                 470                 475                 480 


Ala Gln Ile Ile Thr Glu Lys Thr Ser Pro Lys Thr Ser Asn Pro Phe 
                485                 490                 495     


Leu Val Ala Ile His Asp Ser Glu Ala Asp Tyr Val Thr Thr Asp Asn 
            500                 505                 510         


Leu Ser Lys Val Thr Glu Ala Val Val Ala Thr Met Pro Glu Gly Leu 
        515                 520                 525             


Thr Pro Asp Leu Val Gln Glu Ala Cys Glu Ser Glu Leu Asn Glu Ala 
    530                 535                 540                 


Thr Gly Thr Lys Ile Ala Tyr Glu Thr Lys Val Asp Leu Val Gln Thr 
545                 550                 555                 560 


Ser Glu Ala Ile Gln Glu Ser Ile Tyr Pro Thr Ala Gln Leu Cys Pro 
                565                 570                 575     


Ser Phe Glu Glu Ala Glu Ala Thr Pro Ser Pro Val Leu Pro Asp Ile 
            580                 585                 590         


Val Met Glu Ala Pro Leu Asn Ser Leu Leu Pro Ser Thr Gly Ala Ser 
        595                 600                 605             


Val Ala Gln Pro Ser Ala Ser Pro Leu Glu Val Pro Ser Pro Val Ser 
    610                 615                 620                 


Tyr Asp Gly Ile Lys Leu Glu Pro Glu Asn Pro Pro Pro Tyr Glu Glu 
625                 630                 635                 640 


Ala Met Ser Val Ala Leu Lys Thr Ser Asp Ser Lys Glu Glu Ile Lys 
                645                 650                 655     


Glu Pro Glu Ser Phe Asn Ala Ala Ala Gln Glu Ala Glu Ala Pro Tyr 
            660                 665                 670         


Ile Ser Ile Ala Cys Asp Leu Ile Lys Glu Thr Lys Leu Ser Thr Glu 
        675                 680                 685             


Pro Ser Pro Glu Phe Ser Asn Tyr Ser Glu Ile Ala Lys Phe Glu Lys 
    690                 695                 700                 


Ser Val Pro Asp His Cys Glu Leu Val Asp Asp Ser Ser Pro Glu Ser 
705                 710                 715                 720 


Glu Pro Val Asp Leu Phe Ser Asp Asp Ser Ile Pro Glu Val Pro Gln 
                725                 730                 735     


Thr Gln Glu Glu Ala Val Met Leu Met Lys Glu Ser Leu Thr Glu Val 
            740                 745                 750         


Ser Glu Thr Val Thr Gln His Lys His Lys Glu Arg Leu Ser Ala Ser 
        755                 760                 765             


Pro Gln Glu Val Gly Lys Pro Tyr Leu Glu Ser Phe Gln Pro Asn Leu 
    770                 775                 780                 


His Ile Thr Lys Asp Ala Ala Ser Asn Glu Ile Pro Thr Leu Thr Lys 
785                 790                 795                 800 


Lys Glu Thr Ile Ser Leu Gln Met Glu Glu Phe Asn Thr Ala Ile Tyr 
                805                 810                 815     


Ser Asn Asp Asp Leu Leu Ser Ser Lys Glu Asp Lys Met Lys Glu Ser 
            820                 825                 830         


Glu Thr Phe Ser Asp Ser Ser Pro Ile Glu Ile Ile Asp Glu Phe Pro 
        835                 840                 845             


Thr Phe Val Ser Ala Lys Asp Asp Ser Pro Lys Glu Tyr Thr Asp Leu 
    850                 855                 860                 


Glu Val Ser Asn Lys Ser Glu Ile Ala Asn Val Gln Ser Gly Ala Asn 
865                 870                 875                 880 


Ser Leu Pro Cys Ser Glu Leu Pro Cys Asp Leu Ser Phe Lys Asn Thr 
                885                 890                 895     


Tyr Pro Lys Asp Glu Ala His Val Ser Asp Glu Phe Ser Lys Ser Arg 
            900                 905                 910         


Ser Ser Val Ser Lys Val Pro Leu Leu Leu Pro Asn Val Ser Ala Leu 
        915                 920                 925             


Glu Ser Gln Ile Glu Met Gly Asn Ile Val Lys Pro Lys Val Leu Thr 
    930                 935                 940                 


Lys Glu Ala Glu Glu Lys Leu Pro Ser Asp Thr Glu Lys Glu Asp Arg 
945                 950                 955                 960 


Ser Leu Thr Ala Val Leu Ser Ala Glu Leu Asn Lys Thr Ser Val Val 
                965                 970                 975     


Asp Leu Leu Tyr Trp Arg Asp Ile Lys Lys Thr Gly Val Val Phe Gly 
            980                 985                 990         


Ala Ser Leu Phe Leu Leu Leu Ser  Leu Thr Val Phe Ser  Ile Val Ser 
        995                 1000                 1005             


Val Thr  Ala Tyr Ile Ala Leu  Ala Leu Leu Ser Val  Thr Ile Ser 
    1010                 1015                 1020             


Phe Arg  Ile Tyr Lys Gly Val  Ile Gln Ala Ile Gln  Lys Ser Asp 
    1025                 1030                 1035             


Glu Gly  His Pro Phe Arg Ala  Tyr Leu Glu Ser Glu  Val Ala Ile 
    1040                 1045                 1050             


Ser Glu  Glu Leu Val Gln Lys  Tyr Ser Asn Ser Ala  Leu Gly His 
    1055                 1060                 1065             


Val Asn  Ser Thr Ile Lys Glu  Leu Arg Arg Leu Phe  Leu Val Asp 
    1070                 1075                 1080             


Asp Leu  Val Asp Ser Leu Lys  Phe Ala Val Leu Met  Trp Val Phe 
    1085                 1090                 1095             


Thr Tyr  Val Gly Ala Leu Phe  Asn Gly Leu Thr Leu  Leu Ile Leu 
    1100                 1105                 1110             


Ala Leu  Ile Ser Leu Phe Ser  Ile Pro Val Ile Tyr  Glu Arg His 
    1115                 1120                 1125             


Gln Ala  Gln Ile Asp His Tyr  Leu Gly Leu Ala Asn  Lys Ser Val 
    1130                 1135                 1140             


Lys Asp  Ala Met Ala Lys Ile  Gln Ala Lys Ile Pro  Gly Leu Lys 
    1145                 1150                 1155             


Arg Lys  Ala Glu 
    1160         


<210>  11
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  5'-Nogo-A-WT/KO locus primer

<400>  11
tgctttgaat tattccaagt agtcc                                           25


<210>  12
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  3'-Nogo-A-WT locus primer

<400>  12
agtgagtacc cagctgcac                                                  19


<210>  13
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  3'-Nogo-A-KO locus primer

<400>  13
cctacccggt agaatatcga taagc                                           25


<210>  14
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  Nogo-A Fwd primer

<400>  14
cctctctggc aattctctct agaag                                           25


<210>  15
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  Nogo-A Rev primer

<400>  15
aggggctcgg gctcagtgg                                                  19


<210>  16
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Nogo-B Fwd primer

<400>  16
ctgaaccaat tcctctgata tggc                                            24


<210>  17
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  Nogo-B Rev primer

<400>  17
aggggctcgg gctcagtgg                                                  19


<210>  18
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Nogo-C Fwd primer

<400>  18
tgctggaggg cagatcgtgg c                                               21


<210>  19
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Nogo-C Rev primer

<400>  19
ctgaaccaat tcctctgata tgg                                             23


<210>  20
<211>  460
<212>  PRT
<213>  artificial sequence

<220>
<223>  2A10 humanized Heavy chain H20

<400>  20

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Lys Ala Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Glu Leu Gly Gln Gly Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Trp Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Trp Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        355                 360                 365             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460 


<210>  21
<211>  462
<212>  PRT
<213>  artificial sequence

<220>
<223>  2A10 humanized heavy chain H26

<400>  21

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Arg Ala Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Glu Leu Met Gln Gly Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Ala Gly Ala Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  22
<211>  462
<212>  PRT
<213>  artificial sequence

<220>
<223>  2A10 humanized heavy chain H27

<400>  22

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Glu Leu Met Gln Gly Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Ala Gly Ala Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  23
<211>  462
<212>  PRT
<213>  artificial sequence

<220>
<223>  2A10 humanized heavy chain H28

<400>  23

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Lys Ala Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Glu Leu Met Gln Gly Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Ala Gly Ala Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  24
<211>  237
<212>  PRT
<213>  artificial sequence

<220>
<223>  2A10 Light chain L16

<400>  24

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Asn Pro Val 
            20                  25                  30          


Thr Leu Gly Gln Pro Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu 
        35                  40                  45              


Leu Tyr Lys Asp Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Met Ser Thr Arg Ala Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Leu Val Glu Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Trp Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  25
<211>  237
<212>  PRT
<213>  artificial sequence 

<220>
<223>  2A10 light chain L13

<400>  25

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu 
        35                  40                  45              


Leu Tyr Lys Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Met Ser Thr Arg Ala Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Leu Val Glu Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Trp Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  26
<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  2A10 VH domain H20

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Leu Gly Gln Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  27
<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  2A10 VH domain H27

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Leu Met Gln Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  28
<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  2A10 VH domain H28

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Leu Met Gln Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  29
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  2A10 VL domain L13

<400>  29

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Lys 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Met Ser Thr Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Leu 
                85                  90                  95      


Val Glu Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  30
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  2A10 VL domain L16

<400>  30

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Lys 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Met Ser Thr Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Leu 
                85                  90                  95      


Val Glu Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  31
<211>  220
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mouse 11C7 VH domain

<400>  31

Met Asp Phe Gly Leu Ile Phe Phe Ile Val Gly Leu Leu Lys Gly Val 
1               5                   10                  15      


Gln Cys Glu Val Lys Leu Leu Glu Ser Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Lys Leu Ser Cys Val Val Ser Gly Phe Asp Phe Arg Arg 
        35                  40                  45              


Asn Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    50                  55                  60                  


Ile Gly Glu Ile Asn Pro Asp Ser Ser Lys Ile Asn Tyr Thr Pro Ser 
65                  70                  75                  80  


Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
                85                  90                  95      


Tyr Leu Gln Val Ser Thr Val Arg Ser Glu Asp Thr Ala Leu Tyr Thr 
            100                 105                 110         


Cys Val Arg Pro Val Trp Met Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr 
    130                 135                 140                 


Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp 
                165                 170                 175     


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser 
        195                 200                 205             


Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala 
    210                 215                 220 


<210>  32
<211>  237
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mouse 11C7 light chain

<400>  32

Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Arg Glu 
1               5                   10                  15      


Thr Ser Gly Asp Val Leu Leu Thr Gln Thr Pro Leu Thr Leu Ser Ile 
            20                  25                  30          


Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu His Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser 
65                  70                  75                  80  


Gly Val Pro Asp Glu Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Gly Asp Leu Gly Leu Tyr Tyr Cys 
            100                 105                 110         


Trp Gln Gly Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Gly Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Asp Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu 
        195                 200                 205             


Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser 
    210                 215                 220                 


Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  33
<211>  246
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human 6A3 VH domain

<400>  33

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Lys Gln Asp Gly Ser Gln Lys Asn Tyr Val 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Arg Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Thr Glu Leu Phe Asp Leu Trp Gly Arg Gly Ser Leu 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro 
                245     


<210>  34
<211>  234
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human 6A3 VL domain

<400>  34

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Asn Trp Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  35
<211>  260
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fragment 680-939 human Nogo-A

<400>  35

Pro Glu Asn Ile Asn Ala Ala Leu Gln Glu Thr Glu Ala Pro Tyr Ile 
1               5                   10                  15      


Ser Ile Ala Cys Asp Leu Ile Lys Glu Thr Lys Leu Ser Ala Glu Pro 
            20                  25                  30          


Ala Pro Asp Phe Ser Asp Tyr Ser Glu Met Ala Lys Val Glu Gln Pro 
        35                  40                  45              


Val Pro Asp His Ser Glu Leu Val Glu Asp Ser Ser Pro Asp Ser Glu 
    50                  55                  60                  


Pro Val Asp Leu Phe Ser Asp Asp Ser Ile Pro Asp Val Pro Gln Lys 
65                  70                  75                  80  


Gln Asp Glu Thr Val Met Leu Val Lys Glu Ser Leu Thr Glu Thr Ser 
                85                  90                  95      


Phe Glu Ser Met Ile Glu Tyr Glu Asn Lys Glu Lys Leu Ser Ala Leu 
            100                 105                 110         


Pro Pro Glu Gly Gly Lys Pro Tyr Leu Glu Ser Phe Lys Leu Ser Leu 
        115                 120                 125             


Asp Asn Thr Lys Asp Thr Leu Leu Pro Asp Glu Val Ser Thr Leu Ser 
    130                 135                 140                 


Lys Lys Glu Lys Ile Pro Leu Gln Met Glu Glu Leu Ser Thr Ala Val 
145                 150                 155                 160 


Tyr Ser Asn Asp Asp Leu Phe Ile Ser Lys Glu Ala Gln Ile Arg Glu 
                165                 170                 175     


Thr Glu Thr Phe Ser Asp Ser Ser Pro Ile Glu Ile Ile Asp Glu Phe 
            180                 185                 190         


Pro Thr Leu Ile Ser Ser Lys Thr Asp Ser Phe Ser Lys Leu Ala Arg 
        195                 200                 205             


Glu Tyr Thr Asp Leu Glu Val Ser His Lys Ser Glu Ile Ala Asn Ala 
    210                 215                 220                 


Pro Asp Gly Ala Gly Ser Leu Pro Cys Thr Glu Leu Pro His Asp Leu 
225                 230                 235                 240 


Ser Leu Lys Asn Ile Gln Pro Lys Val Glu Glu Lys Ile Ser Phe Ser 
                245                 250                 255     


Asp Asp Phe Ser 
            260 


<210>  36
<211>  188
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fragment 940-1127 Human Nogo-A

<400>  36

Lys Asn Gly Ser Ala Thr Ser Lys Val Leu Leu Leu Pro Pro Asp Val 
1               5                   10                  15      


Ser Ala Leu Ala Thr Gln Ala Glu Ile Glu Ser Ile Val Lys Pro Lys 
            20                  25                  30          


Val Leu Val Lys Glu Ala Glu Lys Lys Leu Pro Ser Asp Thr Glu Lys 
        35                  40                  45              


Glu Asp Arg Ser Pro Ser Ala Ile Phe Ser Ala Glu Leu Ser Lys Thr 
    50                  55                  60                  


Ser Val Val Asp Leu Leu Tyr Trp Arg Asp Ile Lys Lys Thr Gly Val 
65                  70                  75                  80  


Val Phe Gly Ala Ser Leu Phe Leu Leu Leu Ser Leu Thr Val Phe Ser 
                85                  90                  95      


Ile Val Ser Val Thr Ala Tyr Ile Ala Leu Ala Leu Leu Ser Val Thr 
            100                 105                 110         


Ile Ser Phe Arg Ile Tyr Lys Gly Val Ile Gln Ala Ile Gln Lys Ser 
        115                 120                 125             


Asp Glu Gly His Pro Phe Arg Ala Tyr Leu Glu Ser Glu Val Ala Ile 
    130                 135                 140                 


Ser Glu Glu Leu Val Gln Lys Tyr Ser Asn Ser Ala Leu Gly His Val 
145                 150                 155                 160 


Asn Cys Thr Ile Lys Glu Leu Arg Arg Leu Phe Leu Val Asp Asp Leu 
                165                 170                 175     


Val Asp Ser Leu Lys Phe Ala Val Leu Met Trp Val 
            180                 185             


<210>  37
<211>  979
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fragment 1-979 Human Nogo-A

<400>  37

Met Glu Asp Leu Asp Gln Ser Pro Leu Val Ser Ser Ser Asp Ser Pro 
1               5                   10                  15      


Pro Arg Pro Gln Pro Ala Phe Lys Tyr Gln Phe Val Arg Glu Pro Glu 
            20                  25                  30          


Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Asp 
        35                  40                  45              


Leu Glu Glu Leu Glu Val Leu Glu Arg Lys Pro Ala Ala Gly Leu Ser 
    50                  55                  60                  


Ala Ala Pro Val Pro Thr Ala Pro Ala Ala Gly Ala Pro Leu Met Asp 
65                  70                  75                  80  


Phe Gly Asn Asp Phe Val Pro Pro Ala Pro Arg Gly Pro Leu Pro Ala 
                85                  90                  95      


Ala Pro Pro Val Ala Pro Glu Arg Gln Pro Ser Trp Asp Pro Ser Pro 
            100                 105                 110         


Val Ser Ser Thr Val Pro Ala Pro Ser Pro Leu Ser Ala Ala Ala Val 
        115                 120                 125             


Ser Pro Ser Lys Leu Pro Glu Asp Asp Glu Pro Pro Ala Arg Pro Pro 
    130                 135                 140                 


Pro Pro Pro Pro Ala Ser Val Ser Pro Gln Ala Glu Pro Val Trp Thr 
145                 150                 155                 160 


Pro Pro Ala Pro Ala Pro Ala Ala Pro Pro Ser Thr Pro Ala Ala Pro 
                165                 170                 175     


Lys Arg Arg Gly Ser Ser Gly Ser Val Asp Glu Thr Leu Phe Ala Leu 
            180                 185                 190         


Pro Ala Ala Ser Glu Pro Val Ile Arg Ser Ser Ala Glu Asn Met Asp 
        195                 200                 205             


Leu Lys Glu Gln Pro Gly Asn Thr Ile Ser Ala Gly Gln Glu Asp Phe 
    210                 215                 220                 


Pro Ser Val Leu Leu Glu Thr Ala Ala Ser Leu Pro Ser Leu Ser Pro 
225                 230                 235                 240 


Leu Ser Ala Ala Ser Phe Lys Glu His Glu Tyr Leu Gly Asn Leu Ser 
                245                 250                 255     


Thr Val Leu Pro Thr Glu Gly Thr Leu Gln Glu Asn Val Ser Glu Ala 
            260                 265                 270         


Ser Lys Glu Val Ser Glu Lys Ala Lys Thr Leu Leu Ile Asp Arg Asp 
        275                 280                 285             


Leu Thr Glu Phe Ser Glu Leu Glu Tyr Ser Glu Met Gly Ser Ser Phe 
    290                 295                 300                 


Ser Val Ser Pro Lys Ala Glu Ser Ala Val Ile Val Ala Asn Pro Arg 
305                 310                 315                 320 


Glu Glu Ile Ile Val Lys Asn Lys Asp Glu Glu Glu Lys Leu Val Ser 
                325                 330                 335     


Asn Asn Ile Leu His Asn Gln Gln Glu Leu Pro Thr Ala Leu Thr Lys 
            340                 345                 350         


Leu Val Lys Glu Asp Glu Val Val Ser Ser Glu Lys Ala Lys Asp Ser 
        355                 360                 365             


Phe Asn Glu Lys Arg Val Ala Val Glu Ala Pro Met Arg Glu Glu Tyr 
    370                 375                 380                 


Ala Asp Phe Lys Pro Phe Glu Arg Val Trp Glu Val Lys Asp Ser Lys 
385                 390                 395                 400 


Glu Asp Ser Asp Met Leu Ala Ala Gly Gly Lys Ile Glu Ser Asn Leu 
                405                 410                 415     


Glu Ser Lys Val Asp Lys Lys Cys Phe Ala Asp Ser Leu Glu Gln Thr 
            420                 425                 430         


Asn His Glu Lys Asp Ser Glu Ser Ser Asn Asp Asp Thr Ser Phe Pro 
        435                 440                 445             


Ser Thr Pro Glu Gly Ile Lys Asp Arg Ser Gly Ala Tyr Ile Thr Cys 
    450                 455                 460                 


Ala Pro Phe Asn Pro Ala Ala Thr Glu Ser Ile Ala Thr Asn Ile Phe 
465                 470                 475                 480 


Pro Leu Leu Gly Asp Pro Thr Ser Glu Asn Lys Thr Asp Glu Lys Lys 
                485                 490                 495     


Ile Glu Glu Lys Lys Ala Gln Ile Val Thr Glu Lys Asn Thr Ser Thr 
            500                 505                 510         


Lys Thr Ser Asn Pro Phe Leu Val Ala Ala Gln Asp Ser Glu Thr Asp 
        515                 520                 525             


Tyr Val Thr Thr Asp Asn Leu Thr Lys Val Thr Glu Glu Val Val Ala 
    530                 535                 540                 


Asn Met Pro Glu Gly Leu Thr Pro Asp Leu Val Gln Glu Ala Cys Glu 
545                 550                 555                 560 


Ser Glu Leu Asn Glu Val Thr Gly Thr Lys Ile Ala Tyr Glu Thr Lys 
                565                 570                 575     


Met Asp Leu Val Gln Thr Ser Glu Val Met Gln Glu Ser Leu Tyr Pro 
            580                 585                 590         


Ala Ala Gln Leu Cys Pro Ser Phe Glu Glu Ser Glu Ala Thr Pro Ser 
        595                 600                 605             


Pro Val Leu Pro Asp Ile Val Met Glu Ala Pro Leu Asn Ser Ala Val 
    610                 615                 620                 


Pro Ser Ala Gly Ala Ser Val Ile Gln Pro Ser Ser Ser Pro Leu Glu 
625                 630                 635                 640 


Ala Ser Ser Val Asn Tyr Glu Ser Ile Lys His Glu Pro Glu Asn Pro 
                645                 650                 655     


Pro Pro Tyr Glu Glu Ala Met Ser Val Ser Leu Lys Lys Val Ser Gly 
            660                 665                 670         


Ile Lys Glu Glu Ile Lys Glu Pro Glu Asn Ile Asn Ala Ala Leu Gln 
        675                 680                 685             


Glu Thr Glu Ala Pro Tyr Ile Ser Ile Ala Cys Asp Leu Ile Lys Glu 
    690                 695                 700                 


Thr Lys Leu Ser Ala Glu Pro Ala Pro Asp Phe Ser Asp Tyr Ser Glu 
705                 710                 715                 720 


Met Ala Lys Val Glu Gln Pro Val Pro Asp His Ser Glu Leu Val Glu 
                725                 730                 735     


Asp Ser Ser Pro Asp Ser Glu Pro Val Asp Leu Phe Ser Asp Asp Ser 
            740                 745                 750         


Ile Pro Asp Val Pro Gln Lys Gln Asp Glu Thr Val Met Leu Val Lys 
        755                 760                 765             


Glu Ser Leu Thr Glu Thr Ser Phe Glu Ser Met Ile Glu Tyr Glu Asn 
    770                 775                 780                 


Lys Glu Lys Leu Ser Ala Leu Pro Pro Glu Gly Gly Lys Pro Tyr Leu 
785                 790                 795                 800 


Glu Ser Phe Lys Leu Ser Leu Asp Asn Thr Lys Asp Thr Leu Leu Pro 
                805                 810                 815     


Asp Glu Val Ser Thr Leu Ser Lys Lys Glu Lys Ile Pro Leu Gln Met 
            820                 825                 830         


Glu Glu Leu Ser Thr Ala Val Tyr Ser Asn Asp Asp Leu Phe Ile Ser 
        835                 840                 845             


Lys Glu Ala Gln Ile Arg Glu Thr Glu Thr Phe Ser Asp Ser Ser Pro 
    850                 855                 860                 


Ile Glu Ile Ile Asp Glu Phe Pro Thr Leu Ile Ser Ser Lys Thr Asp 
865                 870                 875                 880 


Ser Phe Ser Lys Leu Ala Arg Glu Tyr Thr Asp Leu Glu Val Ser His 
                885                 890                 895     


Lys Ser Glu Ile Ala Asn Ala Pro Asp Gly Ala Gly Ser Leu Pro Cys 
            900                 905                 910         


Thr Glu Leu Pro His Asp Leu Ser Leu Lys Asn Ile Gln Pro Lys Val 
        915                 920                 925             


Glu Glu Lys Ile Ser Phe Ser Asp Asp Phe Ser Lys Asn Gly Ser Ala 
    930                 935                 940                 


Thr Ser Lys Val Leu Leu Leu Pro Pro Asp Val Ser Ala Leu Ala Thr 
945                 950                 955                 960 


Gln Ala Glu Ile Glu Ser Ile Val Lys Pro Lys Val Leu Val Lys Glu 
                965                 970                 975     


Ala Glu Lys 
            


<210>  38
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fragment 342-357 Human Nogo-A

<400>  38

Asn Gln Gln Glu Leu Pro Thr Ala Leu Thr Lys Leu Val Lys Glu Asp 
1               5                   10                  15      


<210>  39
<211>  182
<212>  PRT
<213>  artificial

<220>
<223>  Fragment 544-725 Human Nogo-A

<400>  39

Ala Asn Met Pro Glu Gly Leu Thr Pro Asp Leu Val Gln Glu Ala Cys 
1               5                   10                  15      


Glu Ser Glu Leu Asn Glu Val Thr Gly Thr Lys Ile Ala Tyr Glu Thr 
            20                  25                  30          


Lys Met Asp Leu Val Gln Thr Ser Glu Val Met Gln Glu Ser Leu Tyr 
        35                  40                  45              


Pro Ala Ala Gln Leu Cys Pro Ser Phe Glu Glu Ser Glu Ala Thr Pro 
    50                  55                  60                  


Ser Pro Val Leu Pro Asp Ile Val Met Glu Ala Pro Leu Asn Ser Ala 
65                  70                  75                  80  


Val Pro Ser Ala Gly Ala Ser Val Ile Gln Pro Ser Ser Ser Pro Leu 
                85                  90                  95      


Glu Ala Ser Ser Val Asn Tyr Glu Ser Ile Lys His Glu Pro Glu Asn 
            100                 105                 110         


Pro Pro Pro Tyr Glu Glu Ala Met Ser Val Ser Leu Lys Lys Val Ser 
        115                 120                 125             


Gly Ile Lys Glu Glu Ile Lys Glu Pro Glu Asn Ile Asn Ala Ala Leu 
    130                 135                 140                 


Gln Glu Thr Glu Ala Pro Tyr Ile Ser Ile Ala Cys Asp Leu Ile Lys 
145                 150                 155                 160 


Glu Thr Lys Leu Ser Ala Glu Pro Ala Pro Asp Phe Ser Asp Tyr Ser 
                165                 170                 175     


Glu Met Ala Lys Val Glu 
            180         


<210>  40
<211>  182
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fragment 567-748 Human Nogo-A

<400>  40

Thr Gly Thr Lys Ile Ala Tyr Glu Thr Lys Met Asp Leu Val Gln Thr 
1               5                   10                  15      


Ser Glu Val Met Gln Glu Ser Leu Tyr Pro Ala Ala Gln Leu Cys Pro 
            20                  25                  30          


Ser Phe Glu Glu Ser Glu Ala Thr Pro Ser Pro Val Leu Pro Asp Ile 
        35                  40                  45              


Val Met Glu Ala Pro Leu Asn Ser Ala Val Pro Ser Ala Gly Ala Ser 
    50                  55                  60                  


Val Ile Gln Pro Ser Ser Ser Pro Leu Glu Ala Ser Ser Val Asn Tyr 
65                  70                  75                  80  


Glu Ser Ile Lys His Glu Pro Glu Asn Pro Pro Pro Tyr Glu Glu Ala 
                85                  90                  95      


Met Ser Val Ser Leu Lys Lys Val Ser Gly Ile Lys Glu Glu Ile Lys 
            100                 105                 110         


Glu Pro Glu Asn Ile Asn Ala Ala Leu Gln Glu Thr Glu Ala Pro Tyr 
        115                 120                 125             


Ile Ser Ile Ala Cys Asp Leu Ile Lys Glu Thr Lys Leu Ser Ala Glu 
    130                 135                 140                 


Pro Ala Pro Asp Phe Ser Asp Tyr Ser Glu Met Ala Lys Val Glu Gln 
145                 150                 155                 160 


Pro Val Pro Asp His Ser Glu Leu Val Glu Asp Ser Ser Pro Asp Ser 
                165                 170                 175     


Glu Pro Val Asp Leu Phe 
            180         


<210>  41
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fragment 610-621 Human Nogo-A

<400>  41

Val Leu Pro Asp Ile Val Met Glu Ala Pro Leu Asn 
1               5                   10          


<210>  42
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fragment 101-118 Bovine Nogo-A

<400>  42

Asn Tyr Glu Ser Ile Lys Phe Glu Pro Glu Asn Pro Pro Pro Tyr Glu 
1               5                   10                  15      


Glu Ala 
        


<210>  43
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fragment 623-640 Rat Nogo-A

<400>  43

Ser Tyr Asp Ser Ile Lys Leu Glu Pro Glu Asn Pro Pro Pro Tyr Glu 
1               5                   10                  15      


Glu Ala 
        


