
                                SEQUENCE LISTING

<110> aTyr Pharma Inc.
      Pangu Biopharma Limited
      Greene, Leslie Ann
      Chiang, Kyle P.
      Hong, Fei
      Vasserot, Alain P.
      Lo, Wing-Sze
      Watkins, Jeffry D.
      Quinn, Cheryl L.
      Mendlein, John D.
      

<120> INNOVATIVE DISCOVERY OF THERAPEUTIC,
  DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS
  OF ASPARTYL-tRNA SYNTHETASES
  

<130> 120161.432PC

<140> PCT                 
<141> 2011-07-12  

<150> US 61/363,589       
<151> 2010-07-12  

<150> US 61/363,586       
<151> 2010-07-12  

<150> US 61/363,583       
<151> 2010-07-12  

<160> 105

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 77
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 1
aggaggtaaa acatatgcat catcatcatc atcacggtaa gcctatccct aaccctttgc 60
tcggtctcga ttctacg                                                77

<210> 2
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 2
taatgactcg ag                                                     12

<210> 3
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 3
aggagataaa acatatg                                                17

<210> 4
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 4
aggaggtaaa acat                                                   14

<210> 5
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 5
aggagataaa acat                                                   14

<210> 6
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 6
gaaggagata tacat                                                  15

<210> 7
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 7
ggtaagccta tccctaaccc tctcctcggt ctcgattcta cgcaccacca tcatcaccat 60
taatgactcg ag                                                     72

<210> 8
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 8
catatgcatc atcatcatca tcacggtaag cctatcccta accctctcct cggtctcgat 60
tctacgggat cc                                                     72

<210> 9
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 9
ctcgagtaat ga                                                     12

<210> 10
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 10
catatgggat cc                                                     12

<210> 11
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 11
ctcgagggta agcctatccc taaccctctc ctcggtctcg attctacgca ccaccaccac 60
caccactaat ga                                                     72

<210> 12
<211> 154
<212> PRT
<213> Homo sapiens

<400> 12
Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu
 1               5                  10                  15      
Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser
            20                  25                  30          
Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val
        35                  40                  45              
Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala
    50                  55                  60                  
Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu
65                  70                  75                  80  
Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His
                85                  90                  95      
Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser
            100                 105                 110         
Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly
        115                 120                 125             
Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val
    130                 135                 140                 
Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu
145                 150                 


<210> 13
<211> 462
<212> DNA
<213> Homo sapiens

<400> 13
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg 60
gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa 120
ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt 180
tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta 240
cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag 300
atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg 360
agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag 420
aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tg                    462

<210> 14
<211> 274
<212> PRT
<213> Homo sapiens

<400> 14
Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu
 1               5                  10                  15      
Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser
            20                  25                  30          
Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val
        35                  40                  45              
Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala
    50                  55                  60                  
Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu
65                  70                  75                  80  
Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His
                85                  90                  95      
Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser
            100                 105                 110         
Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly
        115                 120                 125             
Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val
    130                 135                 140                 
Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val
145                 150                 155                 160 
Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln
                165                 170                 175     
Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser
            180                 185                 190         
Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu
        195                 200                 205             
Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile
    210                 215                 220                 
Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe
225                 230                 235                 240 
Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met
                245                 250                 255     
Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe
            260                 265                 270         
Arg Ala
        


<210> 15
<211> 822
<212> DNA
<213> Homo sapiens

<400> 15
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg 60
gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa 120
ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt 180
tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta 240
cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag 300
atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg 360
agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag 420
aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt 480
cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta 540
gacaacagag tcattgatct taggacatca actagtcagg cagtcttccg tctccagtct 600
ggcatctgcc atctcttccg agaaacttta attaacaaag gttttgtgga aatccaaact 660
cctaaaatta tttcagctgc cagtgaagga ggagccaatg tttttactgt gtcatatttt 720
aaaaataatg catacctggc tcagtcccca cagctatata agcaaatgtg catttgtgct 780
gattttgaga aggttttctc tattggacca gtattcagag cg                    822

<210> 16
<211> 224
<212> PRT
<213> Homo sapiens

<400> 16
Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu
 1               5                  10                  15      
Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser
            20                  25                  30          
Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val
        35                  40                  45              
Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala
    50                  55                  60                  
Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu
65                  70                  75                  80  
Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His
                85                  90                  95      
Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser
            100                 105                 110         
Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly
        115                 120                 125             
Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val
    130                 135                 140                 
Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val
145                 150                 155                 160 
Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln
                165                 170                 175     
Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser
            180                 185                 190         
Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu
        195                 200                 205             
Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile
    210                 215                 220                 


<210> 17
<211> 672
<212> DNA
<213> Homo sapiens

<400> 17
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg 60
gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa 120
ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt 180
tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta 240
cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag 300
atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg 360
agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag 420
aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt 480
cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta 540
gacaacagag tcattgatct taggacatca actagtcagg cagtcttccg tctccagtct 600
ggcatctgcc atctcttccg agaaacttta attaacaaag gttttgtgga aatccaaact 660
cctaaaatta tt                                                     672

<210> 18
<211> 15
<212> PRT
<213> Mus musculus

<400> 18
Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys
 1               5                  10                  15  


<210> 19
<211> 81
<212> PRT
<213> Mus musculus

<400> 19
Ile Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp
 1               5                  10                  15      
Asp Ala Ile Arg Pro Glu Val Glu Gly Glu Glu Asp Gly Arg Ala Thr
            20                  25                  30          
Val Asn Gln Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr
        35                  40                  45              
Ser Thr Ser Gln Ala Ile Phe Arg Leu Gln Ser Gly Ile Cys His Leu
    50                  55                  60                  
Phe Arg Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro
65                  70                  75                  80  
Lys
    


<210> 20
<211> 19
<212> PRT
<213> Mus musculus

<400> 20
Ile Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser
 1               5                  10                  15      
Tyr Phe Lys
            


<210> 21
<211> 11
<212> PRT
<213> Mus musculus

<400> 21
Glu Ser Ile Ile Asp Val Glu Gly Val Val Arg
 1               5                  10      


<210> 22
<211> 5
<212> PRT
<213> Mus musculus

<400> 22
Lys Val Asn Gln Lys
 1               5  


<210> 23
<211> 15
<212> PRT
<213> Mus musculus

<400> 23
Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys
 1               5                  10                  15  


<210> 24
<211> 115
<212> PRT
<213> Mus musculus

<400> 24
Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile
 1               5                  10                  15      
Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp
            20                  25                  30          
Ala Ile Arg Pro Glu Val Glu Gly Glu Glu Asp Gly Arg Ala Thr Val
        35                  40                  45              
Asn Gln Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser
    50                  55                  60                  
Thr Ser Gln Ala Ile Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe
65                  70                  75                  80  
Arg Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys
                85                  90                  95      
Ile Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser
            100                 105                 110         
Tyr Phe Lys
        115 


<210> 25
<211> 31
<212> PRT
<213> Mus musculus

<400> 25
Glu Ser Ile Ile Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys
 1               5                  10                  15      
Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys
            20                  25                  30      


<210> 26
<211> 31
<212> PRT
<213> Homo sapiens

<400> 26
Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu
 1               5                  10                  15      
Ile Met Asp Ala Ala Glu Ile Glu Phe Trp Phe Gly Leu Glu Thr
            20                  25                  30      


<210> 27
<211> 96
<212> DNA
<213> Homo sapiens

<400> 27
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg 60
gcggaaatcg agttttggtt cgggttagag acttga                           96

<210> 28
<211> 470
<212> PRT
<213> Homo sapiens

<400> 28
Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu
 1               5                  10                  15      
Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser
            20                  25                  30          
Ser Met Ile Gln Ser Gln Glu Lys Pro Gly Lys Gln Cys Phe Leu Val
        35                  40                  45              
Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp
    50                  55                  60                  
His Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu
65                  70                  75                  80  
Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile
                85                  90                  95      
Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr
            100                 105                 110         
Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala
        115                 120                 125             
Val Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn
    130                 135                 140                 
Gln Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr
145                 150                 155                 160 
Ser Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg
                165                 170                 175     
Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile
            180                 185                 190         
Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr
        195                 200                 205             
Phe Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln
    210                 215                 220                 
Met Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val
225                 230                 235                 240 
Phe Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val
                245                 250                 255     
Gly Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met
            260                 265                 270         
Glu Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu
        275                 280                 285             
Arg Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Cys Glu
    290                 295                 300                 
Pro Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala
305                 310                 315                 320 
Leu Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp
                325                 330                 335     
Leu Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys
            340                 345                 350         
Tyr Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg
        355                 360                 365             
Pro Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser
    370                 375                 380                 
Tyr Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg
385                 390                 395                 400 
Ile His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile
                405                 410                 415     
Asp Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala
            420                 425                 430         
Pro Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu
        435                 440                 445             
Phe Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp
    450                 455                 460                 
Pro Lys Arg Leu Thr Pro
465                 470 


<210> 29
<211> 1413
<212> DNA
<213> Homo sapiens

<400> 29
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg 60
gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa 120
ccagggaaac agtgcttctt agtcctacgt cagcagcagt ttaatgtcca ggctcttgtg 180
gcggtgggag accatgcaag caagcagatg gttaaatttg ctgccaacat caacaaagag 240
agcattgtgg atgtagaagg tgttgtgaga aaagtgaatc agaaaattgg aagctgtaca 300
cagcaagacg ttgagttaca tgttcagaag atttatgtga tcagtttggc tgaaccccgt 360
ctgcccctgc agctggatga tgctgttcgg cctgaggcag aaggagaaga ggaaggaaga 420
gctactgtta accaggatac aagattagac aacagagtca ttgatcttag gacatcaact 480
agtcaggcag tcttccgtct ccagtctggc atctgccatc tcttccgaga aactttaatt 540
aacaaaggtt ttgtggaaat ccaaactcct aaaattattt cagctgccag tgaaggagga 600
gccaatgttt ttactgtgtc atattttaaa aataatgcat acctggctca gtccccacag 660
ctatataagc aaatgtgcat ttgtgctgat tttgagaagg ttttctctat tggaccagta 720
ttcagagcgg aagactctaa tacccataga catctaactg agtttgttgg tttggacatt 780
gaaatggctt ttaattacca ttaccacgaa gttatggaag aaattgctga caccatggta 840
caaatattca aaggacttca agaaaggttt cagactgaaa ttcaaacagt gaataaacag 900
ttcccatgtg agccattcaa atttttggag ccaactctaa gactagaata ttgtgaagca 960
ttggctatgc ttagggaagc tggagtcgaa atgggagatg aagacgatct gagcacacca 1020
aatgaaaagc tgttgggtca tttggtaaag gaaaagtatg atacagattt ttatattctt 1080
gataaatatc cattggctgt aagacctttc tataccatgc ctgacccaag aaatcccaaa 1140
cagtccaact cttacgatat gttcatgaga ggagaagaaa tattgtcagg agctcaaaga 1200
atacatgatc ctcaactgct aacagagaga gctttacatc atggaattga tttggagaaa 1260
attaaggctt acattgattc cttccgcttt ggagcccctc ctcatgctgg tggaggcatt 1320
ggattggaac gagttactat gctgtttctg ggattgcata atgttcgtca gacctccatg 1380
ttccctcgtg atcccaaacg actcactcct taa                              1413

<210> 30
<211> 454
<212> PRT
<213> Homo sapiens

<400> 30
Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu
 1               5                  10                  15      
Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser
            20                  25                  30          
Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val
        35                  40                  45              
Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala
    50                  55                  60                  
Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu
65                  70                  75                  80  
Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His
                85                  90                  95      
Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser
            100                 105                 110         
Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly
        115                 120                 125             
Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Thr Ser Thr
    130                 135                 140                 
Ser Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg
145                 150                 155                 160 
Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile
                165                 170                 175     
Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr
            180                 185                 190         
Phe Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln
        195                 200                 205             
Met Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val
    210                 215                 220                 
Phe Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val
225                 230                 235                 240 
Gly Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met
                245                 250                 255     
Glu Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu
            260                 265                 270         
Arg Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Cys Glu
        275                 280                 285             
Pro Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala
    290                 295                 300                 
Leu Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp
305                 310                 315                 320 
Leu Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys
                325                 330                 335     
Tyr Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg
            340                 345                 350         
Pro Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser
        355                 360                 365             
Tyr Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg
    370                 375                 380                 
Ile His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile
385                 390                 395                 400 
Asp Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala
                405                 410                 415     
Pro Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu
            420                 425                 430         
Phe Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp
        435                 440                 445             
Pro Lys Arg Leu Thr Pro
    450                 


<210> 31
<211> 1365
<212> DNA
<213> Homo sapiens

<400> 31
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg 60
gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa 120
ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt 180
tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta 240
cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag 300
atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg 360
agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag 420
aagacatcaa ctagtcaggc agtcttccgt ctccagtctg gcatctgcca tctcttccga 480
gaaactttaa ttaacaaagg ttttgtggaa atccaaactc ctaaaattat ttcagctgcc 540
agtgaaggag gagccaatgt ttttactgtg tcatatttta aaaataatgc atacctggct 600
cagtccccac agctatataa gcaaatgtgc atttgtgctg attttgagaa ggttttctct 660
attggaccag tattcagagc ggaagactct aatacccata gacatctaac tgagtttgtt 720
ggtttggaca ttgaaatggc ttttaattac cattaccacg aagttatgga agaaattgct 780
gacaccatgg tacaaatatt caaaggactt caagaaaggt ttcagactga aattcaaaca 840
gtgaataaac agttcccatg tgagccattc aaatttttgg agccaactct aagactagaa 900
tattgtgaag cattggctat gcttagggaa gctggagtcg aaatgggaga tgaagacgat 960
ctgagcacac caaatgaaaa gctgttgggt catttggtaa aggaaaagta tgatacagat 1020
ttttatattc ttgataaata tccattggct gtaagacctt tctataccat gcctgaccca 1080
agaaatccca aacagtccaa ctcttacgat atgttcatga gaggagaaga aatattgtca 1140
ggagctcaaa gaatacatga tcctcaactg ctaacagaga gagctttaca tcatggaatt 1200
gatttggaga aaattaaggc ttacattgat tccttccgct ttggagcccc tcctcatgct 1260
ggtggaggca ttggattgga acgagttact atgctgtttc tgggattgca taatgttcgt 1320
cagacctcca tgttccctcg tgatcccaaa cgactcactc cttaa                 1365

<210> 32
<211> 452
<212> PRT
<213> Homo sapiens

<400> 32
Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu
 1               5                  10                  15      
Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser
            20                  25                  30          
Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val
        35                  40                  45              
Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala
    50                  55                  60                  
Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu
65                  70                  75                  80  
Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His
                85                  90                  95      
Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser
            100                 105                 110         
Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly
        115                 120                 125             
Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val
    130                 135                 140                 
Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val
145                 150                 155                 160 
Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln
                165                 170                 175     
Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser
            180                 185                 190         
Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu
        195                 200                 205             
Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile
    210                 215                 220                 
Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe
225                 230                 235                 240 
Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met
                245                 250                 255     
Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe
            260                 265                 270         
Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly
        275                 280                 285             
Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu
    290                 295                 300                 
Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Ser
305                 310                 315                 320 
Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr Asp
                325                 330                 335     
Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro Phe
            340                 345                 350         
Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr Asp
        355                 360                 365             
Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile His
    370                 375                 380                 
Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp Leu
385                 390                 395                 400 
Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro Pro
                405                 410                 415     
His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe Leu
            420                 425                 430         
Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro Lys
        435                 440                 445             
Arg Leu Thr Pro
    450         


<210> 33
<211> 1359
<212> DNA
<213> Homo sapiens

<400> 33
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg 60
gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa 120
ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt 180
tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta 240
cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag 300
atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg 360
agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag 420
aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt 480
cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta 540
gacaacagag tcattgatct taggacatca actagtcagg cagtcttccg tctccagtct 600
ggcatctgcc atctcttccg agaaacttta attaacaaag gttttgtgga aatccaaact 660
cctaaaatta tttcagctgc cagtgaagga ggagccaatg tttttactgt gtcatatttt 720
aaaaataatg catacctggc tcagtcccca cagctatata agcaaatgtg catttgtgct 780
gattttgaga aggttttctc tattggacca gtattcagag cggaagactc taatacccat 840
agacatctaa ctgagtttgt tggtttggac attgaaatgg cttttaatta ccattaccac 900
gaagttatgg aagaaattgc tgacaccatg gtacaaatat tcaaaggact tcaagaaagc 960
acaccaaatg aaaagctgtt gggtcatttg gtaaaggaaa agtatgatac agatttttat 1020
attcttgata aatatccatt ggctgtaaga cctttctata ccatgcctga cccaagaaat 1080
cccaaacagt ccaactctta cgatatgttc atgagaggag aagaaatatt gtcaggagct 1140
caaagaatac atgatcctca actgctaaca gagagagctt tacatcatgg aattgatttg 1200
gagaaaatta aggcttacat tgattccttc cgctttggag cccctcctca tgctggtgga 1260
ggcattggat tggaacgagt tactatgctg tttctgggat tgcataatgt tcgtcagacc 1320
tccatgttcc ctcgtgatcc caaacgactc actccttaa                        1359

<210> 34
<211> 85
<212> PRT
<213> Homo sapiens

<400> 34
Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu
 1               5                  10                  15      
Ile Met Asp Ala Ala Glu Asp Trp Asn Glu Leu Leu Cys Cys Phe Trp
            20                  25                  30          
Asp Cys Ile Met Phe Val Arg Pro Pro Cys Ser Leu Val Ile Pro Asn
        35                  40                  45              
Asp Ser Leu Leu Lys Phe Thr Leu Cys His Leu Thr Pro Val Trp Met
    50                  55                  60                  
Thr Glu Arg Asp Pro Ala Ser Lys Lys Lys Lys Lys Lys Glu Ser His
65                  70                  75                  80  
Thr Tyr Ser Phe Gln
                85  


<210> 35
<211> 258
<212> DNA
<213> Homo sapiens

<400> 35
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg 60
gcggaagatt ggaacgagtt actatgctgt ttctgggatt gcataatgtt cgtcagacct 120
ccatgttccc tcgtgatccc aaacgactca ctccttaaat tcacactttg ccacttaact 180
ccagtgtgga tgacagagcg agaccctgcc tcaaaaaaaa aaaaaaaaaa agaaagccac 240
acttattctt ttcagtaa                                               258

<210> 36
<211> 27
<212> PRT
<213> Homo sapiens

<400> 36
Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu
 1               5                  10                  15      
Ile Met Asp Ala Ala Glu Gly Asn Ser Ala Ser
            20                  25          


<210> 37
<211> 84
<212> DNA
<213> Homo sapiens

<400> 37
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg 60
gcggaaggaa acagtgcttc ttag                                        84

<210> 38
<211> 50
<212> DNA
<213> Homo sapiens

<400> 38
gcgggagatc atggacgcgg cggaaatcga gttttggttc gggttagaga            50

<210> 39
<211> 16
<212> PRT
<213> Homo sapiens

<400> 39
Arg Glu Ile Met Asp Ala Ala Glu Ile Glu Phe Trp Phe Gly Leu Glu
 1               5                  10                  15      


<210> 40
<211> 50
<212> DNA
<213> Homo sapiens

<400> 40
atgatacaat cacaagaaaa accagggaaa cagtgcttct tagtcctacg            50

<210> 41
<211> 16
<212> PRT
<213> Homo sapiens

<400> 41
Met Ile Gln Ser Gln Glu Lys Pro Gly Lys Gln Cys Phe Leu Val Leu
 1               5                  10                  15      


<210> 42
<211> 50
<212> DNA
<213> Homo sapiens

<400> 42
agacgttgag ttacatgttc agaagacatc aactagtcag gcagtcttcc            50

<210> 43
<211> 16
<212> PRT
<213> Homo sapiens

<400> 43
Asp Val Glu Leu His Val Gln Lys Thr Ser Thr Ser Gln Ala Val Phe
 1               5                  10                  15      


<210> 44
<211> 50
<212> DNA
<213> Homo sapiens

<400> 44
aaatattcaa aggacttcaa gaaagcacac caaatgaaaa gctgttgggt            50

<210> 45
<211> 16
<212> PRT
<213> Homo sapiens

<400> 45
Ile Phe Lys Gly Leu Gln Glu Ser Thr Pro Asn Glu Lys Leu Leu Gly
 1               5                  10                  15      


<210> 46
<211> 50
<212> DNA
<213> Homo sapiens

<400> 46
gcgggagatc atggacgcgg cggaagattg gaacgagtta ctatgctgtt            50

<210> 47
<211> 16
<212> PRT
<213> Homo sapiens

<400> 47
Arg Glu Ile Met Asp Ala Ala Glu Asp Trp Asn Glu Leu Leu Cys Cys
 1               5                  10                  15      


<210> 48
<211> 50
<212> DNA
<213> Homo sapiens

<400> 48
gcgggagatc atggacgcgg cggaaggaaa cagtgcttct tagtcctacg            50

<210> 49
<211> 13
<212> PRT
<213> Homo sapiens

<400> 49
Arg Glu Ile Met Asp Ala Ala Glu Gly Asn Ser Ala Ser
 1               5                  10              


<210> 50
<211> 184
<212> PRT
<213> Homo sapiens

<400> 50
Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu
 1               5                  10                  15      
Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser
            20                  25                  30          
Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val
        35                  40                  45              
Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala
    50                  55                  60                  
Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu
65                  70                  75                  80  
Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His
                85                  90                  95      
Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser
            100                 105                 110         
Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly
        115                 120                 125             
Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val
    130                 135                 140                 
Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val
145                 150                 155                 160 
Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln
                165                 170                 175     
Asp Thr Arg Leu Asp Asn Arg Val
            180                 


<210> 51
<211> 552
<212> DNA
<213> Homo sapiens

<400> 51
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg 60
gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa 120
ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt 180
tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta 240
cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag 300
atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg 360
agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag 420
aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt 480
cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta 540
gacaacagag tc                                                     552

<210> 52
<211> 298
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 52
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Pro Ser Ala Ser Ala Ser Arg Lys Ser
            20                  25                  30          
Gln Glu Lys Pro Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys
        35                  40                  45              
Glu Arg Tyr Gly Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp
    50                  55                  60                  
Arg Val Leu Val Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu
65                  70                  75                  80  
Val Val Trp Val Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys
                85                  90                  95      
Gln Cys Phe Leu Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu
            100                 105                 110         
Val Ala Val Gly Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Ala
        115                 120                 125             
Asn Ile Asn Lys Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys
    130                 135                 140                 
Val Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His
145                 150                 155                 160 
Val Gln Lys Ile Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu
                165                 170                 175     
Gln Leu Asp Asp Ala Val Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly
            180                 185                 190         
Arg Ala Thr Val Asn Gln Asp Thr Arg Leu Asp Asn Arg Val Ile Asp
        195                 200                 205             
Leu Arg Thr Ser Thr Ser Gln Ala Val Phe Arg Leu Gln Ser Gly Ile
    210                 215                 220                 
Cys His Leu Phe Arg Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile
225                 230                 235                 240 
Gln Thr Pro Lys Ile Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn Val
                245                 250                 255     
Phe Thr Val Ser Tyr Phe Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro
            260                 265                 270         
Gln Leu Tyr Lys Gln Met Cys Ile Cys Ala Asp Phe Glu Lys Val Phe
        275                 280                 285             
Ser Ile Gly Pro Val Phe Arg Ala Leu Glu
    290                 295             


<210> 53
<211> 298
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 53
Met Gly Ser Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro
 1               5                  10                  15      
Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly
            20                  25                  30          
Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val
        35                  40                  45              
Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val
    50                  55                  60                  
Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu
65                  70                  75                  80  
Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly
                85                  90                  95      
Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys
            100                 105                 110         
Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys
        115                 120                 125             
Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile
    130                 135                 140                 
Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp
145                 150                 155                 160 
Ala Val Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val
                165                 170                 175     
Asn Gln Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser
            180                 185                 190         
Thr Ser Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe
        195                 200                 205             
Arg Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys
    210                 215                 220                 
Ile Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser
225                 230                 235                 240 
Tyr Phe Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys
                245                 250                 255     
Gln Met Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro
            260                 265                 270         
Val Phe Arg Ala Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly
        275                 280                 285             
Leu Asp Ser Thr His His His His His His
    290                 295             


<210> 54
<211> 248
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 54
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Pro Ser Ala Ser Ala Ser Arg Lys Ser
            20                  25                  30          
Gln Glu Lys Pro Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys
        35                  40                  45              
Glu Arg Tyr Gly Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp
    50                  55                  60                  
Arg Val Leu Val Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu
65                  70                  75                  80  
Val Val Trp Val Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys
                85                  90                  95      
Gln Cys Phe Leu Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu
            100                 105                 110         
Val Ala Val Gly Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Ala
        115                 120                 125             
Asn Ile Asn Lys Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys
    130                 135                 140                 
Val Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His
145                 150                 155                 160 
Val Gln Lys Ile Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu
                165                 170                 175     
Gln Leu Asp Asp Ala Val Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly
            180                 185                 190         
Arg Ala Thr Val Asn Gln Asp Thr Arg Leu Asp Asn Arg Val Ile Asp
        195                 200                 205             
Leu Arg Thr Ser Thr Ser Gln Ala Val Phe Arg Leu Gln Ser Gly Ile
    210                 215                 220                 
Cys His Leu Phe Arg Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile
225                 230                 235                 240 
Gln Thr Pro Lys Ile Ile Leu Glu
                245             


<210> 55
<211> 248
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 55
Met Gly Ser Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro
 1               5                  10                  15      
Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly
            20                  25                  30          
Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val
        35                  40                  45              
Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val
    50                  55                  60                  
Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu
65                  70                  75                  80  
Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly
                85                  90                  95      
Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys
            100                 105                 110         
Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys
        115                 120                 125             
Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile
    130                 135                 140                 
Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp
145                 150                 155                 160 
Ala Val Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val
                165                 170                 175     
Asn Gln Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser
            180                 185                 190         
Thr Ser Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe
        195                 200                 205             
Arg Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys
    210                 215                 220                 
Ile Ile Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp
225                 230                 235                 240 
Ser Thr His His His His His His
                245             


<210> 56
<211> 208
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 56
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Pro Ser Ala Ser Ala Ser Arg Lys Ser
            20                  25                  30          
Gln Glu Lys Pro Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys
        35                  40                  45              
Glu Arg Tyr Gly Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp
    50                  55                  60                  
Arg Val Leu Val Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu
65                  70                  75                  80  
Val Val Trp Val Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys
                85                  90                  95      
Gln Cys Phe Leu Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu
            100                 105                 110         
Val Ala Val Gly Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Ala
        115                 120                 125             
Asn Ile Asn Lys Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys
    130                 135                 140                 
Val Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His
145                 150                 155                 160 
Val Gln Lys Ile Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu
                165                 170                 175     
Gln Leu Asp Asp Ala Val Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly
            180                 185                 190         
Arg Ala Thr Val Asn Gln Asp Thr Arg Leu Asp Asn Arg Val Leu Glu
        195                 200                 205             


<210> 57
<211> 208
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 57
Met Gly Ser Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro
 1               5                  10                  15      
Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly
            20                  25                  30          
Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val
        35                  40                  45              
Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val
    50                  55                  60                  
Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu
65                  70                  75                  80  
Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly
                85                  90                  95      
Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys
            100                 105                 110         
Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys
        115                 120                 125             
Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile
    130                 135                 140                 
Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp
145                 150                 155                 160 
Ala Val Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val
                165                 170                 175     
Asn Gln Asp Thr Arg Leu Asp Asn Arg Val Leu Glu Gly Lys Pro Ile
            180                 185                 190         
Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
        195                 200                 205             


<210> 58
<211> 494
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 58
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Pro Ser Ala Ser Ala Ser Arg Lys Ser
            20                  25                  30          
Gln Glu Lys Pro Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys
        35                  40                  45              
Glu Arg Tyr Gly Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Gly
    50                  55                  60                  
Lys Gln Cys Phe Leu Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala
65                  70                  75                  80  
Leu Val Ala Val Gly Asp His Ala Ser Lys Gln Met Val Lys Phe Ala
                85                  90                  95      
Ala Asn Ile Asn Lys Glu Ser Ile Val Asp Val Glu Gly Val Val Arg
            100                 105                 110         
Lys Val Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu
        115                 120                 125             
His Val Gln Lys Ile Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro
    130                 135                 140                 
Leu Gln Leu Asp Asp Ala Val Arg Pro Glu Ala Glu Gly Glu Glu Glu
145                 150                 155                 160 
Gly Arg Ala Thr Val Asn Gln Asp Thr Arg Leu Asp Asn Arg Val Ile
                165                 170                 175     
Asp Leu Arg Thr Ser Thr Ser Gln Ala Val Phe Arg Leu Gln Ser Gly
            180                 185                 190         
Ile Cys His Leu Phe Arg Glu Thr Leu Ile Asn Lys Gly Phe Val Glu
        195                 200                 205             
Ile Gln Thr Pro Lys Ile Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn
    210                 215                 220                 
Val Phe Thr Val Ser Tyr Phe Lys Asn Asn Ala Tyr Leu Ala Gln Ser
225                 230                 235                 240 
Pro Gln Leu Tyr Lys Gln Met Cys Ile Cys Ala Asp Phe Glu Lys Val
                245                 250                 255     
Phe Ser Ile Gly Pro Val Phe Arg Ala Glu Asp Ser Asn Thr His Arg
            260                 265                 270         
His Leu Thr Glu Phe Val Gly Leu Asp Ile Glu Met Ala Phe Asn Tyr
        275                 280                 285             
His Tyr His Glu Val Met Glu Glu Ile Ala Asp Thr Met Val Gln Ile
    290                 295                 300                 
Phe Lys Gly Leu Gln Glu Arg Phe Gln Thr Glu Ile Gln Thr Val Asn
305                 310                 315                 320 
Lys Gln Phe Pro Cys Glu Pro Phe Lys Phe Leu Glu Pro Thr Leu Arg
                325                 330                 335     
Leu Glu Tyr Cys Glu Ala Leu Ala Met Leu Arg Glu Ala Gly Val Glu
            340                 345                 350         
Met Gly Asp Glu Asp Asp Leu Ser Thr Pro Asn Glu Lys Leu Leu Gly
        355                 360                 365             
His Leu Val Lys Glu Lys Tyr Asp Thr Asp Phe Tyr Ile Leu Asp Lys
    370                 375                 380                 
Tyr Pro Leu Ala Val Arg Pro Phe Tyr Thr Met Pro Asp Pro Arg Asn
385                 390                 395                 400 
Pro Lys Gln Ser Asn Ser Tyr Asp Met Phe Met Arg Gly Glu Glu Ile
                405                 410                 415     
Leu Ser Gly Ala Gln Arg Ile His Asp Pro Gln Leu Leu Thr Glu Arg
            420                 425                 430         
Ala Leu His His Gly Ile Asp Leu Glu Lys Ile Lys Ala Tyr Ile Asp
        435                 440                 445             
Ser Phe Arg Phe Gly Ala Pro Pro His Ala Gly Gly Gly Ile Gly Leu
    450                 455                 460                 
Glu Arg Val Thr Met Leu Phe Leu Gly Leu His Asn Val Arg Gln Thr
465                 470                 475                 480 
Ser Met Phe Pro Arg Asp Pro Lys Arg Leu Thr Pro Leu Glu
                485                 490                 


<210> 59
<211> 494
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 59
Met Gly Ser Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro
 1               5                  10                  15      
Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly
            20                  25                  30          
Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Gly Lys Gln Cys Phe
        35                  40                  45              
Leu Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val
    50                  55                  60                  
Gly Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn
65                  70                  75                  80  
Lys Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln
                85                  90                  95      
Lys Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys
            100                 105                 110         
Ile Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp
        115                 120                 125             
Asp Ala Val Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr
    130                 135                 140                 
Val Asn Gln Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr
145                 150                 155                 160 
Ser Thr Ser Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu
                165                 170                 175     
Phe Arg Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro
            180                 185                 190         
Lys Ile Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val
        195                 200                 205             
Ser Tyr Phe Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr
    210                 215                 220                 
Lys Gln Met Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly
225                 230                 235                 240 
Pro Val Phe Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu
                245                 250                 255     
Phe Val Gly Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu
            260                 265                 270         
Val Met Glu Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu
        275                 280                 285             
Gln Glu Arg Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro
    290                 295                 300                 
Cys Glu Pro Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Cys
305                 310                 315                 320 
Glu Ala Leu Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu
                325                 330                 335     
Asp Asp Leu Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys
            340                 345                 350         
Glu Lys Tyr Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala
        355                 360                 365             
Val Arg Pro Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser
    370                 375                 380                 
Asn Ser Tyr Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala
385                 390                 395                 400 
Gln Arg Ile His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His
                405                 410                 415     
Gly Ile Asp Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe
            420                 425                 430         
Gly Ala Pro Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr
        435                 440                 445             
Met Leu Phe Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro
    450                 455                 460                 
Arg Asp Pro Lys Arg Leu Thr Pro Leu Glu Gly Lys Pro Ile Pro Asn
465                 470                 475                 480 
Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
                485                 490                 


<210> 60
<211> 478
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 60
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Pro Ser Ala Ser Ala Ser Arg Lys Ser
            20                  25                  30          
Gln Glu Lys Pro Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys
        35                  40                  45              
Glu Arg Tyr Gly Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp
    50                  55                  60                  
Arg Val Leu Val Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu
65                  70                  75                  80  
Val Val Trp Val Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys
                85                  90                  95      
Gln Cys Phe Leu Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu
            100                 105                 110         
Val Ala Val Gly Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Ala
        115                 120                 125             
Asn Ile Asn Lys Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys
    130                 135                 140                 
Val Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His
145                 150                 155                 160 
Val Gln Lys Thr Ser Thr Ser Gln Ala Val Phe Arg Leu Gln Ser Gly
                165                 170                 175     
Ile Cys His Leu Phe Arg Glu Thr Leu Ile Asn Lys Gly Phe Val Glu
            180                 185                 190         
Ile Gln Thr Pro Lys Ile Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn
        195                 200                 205             
Val Phe Thr Val Ser Tyr Phe Lys Asn Asn Ala Tyr Leu Ala Gln Ser
    210                 215                 220                 
Pro Gln Leu Tyr Lys Gln Met Cys Ile Cys Ala Asp Phe Glu Lys Val
225                 230                 235                 240 
Phe Ser Ile Gly Pro Val Phe Arg Ala Glu Asp Ser Asn Thr His Arg
                245                 250                 255     
His Leu Thr Glu Phe Val Gly Leu Asp Ile Glu Met Ala Phe Asn Tyr
            260                 265                 270         
His Tyr His Glu Val Met Glu Glu Ile Ala Asp Thr Met Val Gln Ile
        275                 280                 285             
Phe Lys Gly Leu Gln Glu Arg Phe Gln Thr Glu Ile Gln Thr Val Asn
    290                 295                 300                 
Lys Gln Phe Pro Cys Glu Pro Phe Lys Phe Leu Glu Pro Thr Leu Arg
305                 310                 315                 320 
Leu Glu Tyr Cys Glu Ala Leu Ala Met Leu Arg Glu Ala Gly Val Glu
                325                 330                 335     
Met Gly Asp Glu Asp Asp Leu Ser Thr Pro Asn Glu Lys Leu Leu Gly
            340                 345                 350         
His Leu Val Lys Glu Lys Tyr Asp Thr Asp Phe Tyr Ile Leu Asp Lys
        355                 360                 365             
Tyr Pro Leu Ala Val Arg Pro Phe Tyr Thr Met Pro Asp Pro Arg Asn
    370                 375                 380                 
Pro Lys Gln Ser Asn Ser Tyr Asp Met Phe Met Arg Gly Glu Glu Ile
385                 390                 395                 400 
Leu Ser Gly Ala Gln Arg Ile His Asp Pro Gln Leu Leu Thr Glu Arg
                405                 410                 415     
Ala Leu His His Gly Ile Asp Leu Glu Lys Ile Lys Ala Tyr Ile Asp
            420                 425                 430         
Ser Phe Arg Phe Gly Ala Pro Pro His Ala Gly Gly Gly Ile Gly Leu
        435                 440                 445             
Glu Arg Val Thr Met Leu Phe Leu Gly Leu His Asn Val Arg Gln Thr
    450                 455                 460                 
Ser Met Phe Pro Arg Asp Pro Lys Arg Leu Thr Pro Leu Glu
465                 470                 475             


<210> 61
<211> 478
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 61
Met Gly Ser Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro
 1               5                  10                  15      
Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly
            20                  25                  30          
Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val
        35                  40                  45              
Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val
    50                  55                  60                  
Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu
65                  70                  75                  80  
Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly
                85                  90                  95      
Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys
            100                 105                 110         
Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys
        115                 120                 125             
Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Thr
    130                 135                 140                 
Ser Thr Ser Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu
145                 150                 155                 160 
Phe Arg Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro
                165                 170                 175     
Lys Ile Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val
            180                 185                 190         
Ser Tyr Phe Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr
        195                 200                 205             
Lys Gln Met Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly
    210                 215                 220                 
Pro Val Phe Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu
225                 230                 235                 240 
Phe Val Gly Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu
                245                 250                 255     
Val Met Glu Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu
            260                 265                 270         
Gln Glu Arg Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro
        275                 280                 285             
Cys Glu Pro Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Cys
    290                 295                 300                 
Glu Ala Leu Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu
305                 310                 315                 320 
Asp Asp Leu Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys
                325                 330                 335     
Glu Lys Tyr Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala
            340                 345                 350         
Val Arg Pro Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser
        355                 360                 365             
Asn Ser Tyr Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala
    370                 375                 380                 
Gln Arg Ile His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His
385                 390                 395                 400 
Gly Ile Asp Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe
                405                 410                 415     
Gly Ala Pro Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr
            420                 425                 430         
Met Leu Phe Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro
        435                 440                 445             
Arg Asp Pro Lys Arg Leu Thr Pro Leu Glu Gly Lys Pro Ile Pro Asn
    450                 455                 460                 
Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
465                 470                 475             


<210> 62
<211> 476
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 62
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Pro Ser Ala Ser Ala Ser Arg Lys Ser
            20                  25                  30          
Gln Glu Lys Pro Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys
        35                  40                  45              
Glu Arg Tyr Gly Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp
    50                  55                  60                  
Arg Val Leu Val Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu
65                  70                  75                  80  
Val Val Trp Val Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys
                85                  90                  95      
Gln Cys Phe Leu Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu
            100                 105                 110         
Val Ala Val Gly Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Ala
        115                 120                 125             
Asn Ile Asn Lys Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys
    130                 135                 140                 
Val Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His
145                 150                 155                 160 
Val Gln Lys Ile Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu
                165                 170                 175     
Gln Leu Asp Asp Ala Val Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly
            180                 185                 190         
Arg Ala Thr Val Asn Gln Asp Thr Arg Leu Asp Asn Arg Val Ile Asp
        195                 200                 205             
Leu Arg Thr Ser Thr Ser Gln Ala Val Phe Arg Leu Gln Ser Gly Ile
    210                 215                 220                 
Cys His Leu Phe Arg Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile
225                 230                 235                 240 
Gln Thr Pro Lys Ile Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn Val
                245                 250                 255     
Phe Thr Val Ser Tyr Phe Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro
            260                 265                 270         
Gln Leu Tyr Lys Gln Met Cys Ile Cys Ala Asp Phe Glu Lys Val Phe
        275                 280                 285             
Ser Ile Gly Pro Val Phe Arg Ala Glu Asp Ser Asn Thr His Arg His
    290                 295                 300                 
Leu Thr Glu Phe Val Gly Leu Asp Ile Glu Met Ala Phe Asn Tyr His
305                 310                 315                 320 
Tyr His Glu Val Met Glu Glu Ile Ala Asp Thr Met Val Gln Ile Phe
                325                 330                 335     
Lys Gly Leu Gln Glu Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu
            340                 345                 350         
Val Lys Glu Lys Tyr Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro
        355                 360                 365             
Leu Ala Val Arg Pro Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys
    370                 375                 380                 
Gln Ser Asn Ser Tyr Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser
385                 390                 395                 400 
Gly Ala Gln Arg Ile His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu
                405                 410                 415     
His His Gly Ile Asp Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe
            420                 425                 430         
Arg Phe Gly Ala Pro Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg
        435                 440                 445             
Val Thr Met Leu Phe Leu Gly Leu His Asn Val Arg Gln Thr Ser Met
    450                 455                 460                 
Phe Pro Arg Asp Pro Lys Arg Leu Thr Pro Leu Glu
465                 470                 475     


<210> 63
<211> 476
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 63
Met Gly Ser Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro
 1               5                  10                  15      
Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly
            20                  25                  30          
Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val
        35                  40                  45              
Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val
    50                  55                  60                  
Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu
65                  70                  75                  80  
Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly
                85                  90                  95      
Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys
            100                 105                 110         
Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys
        115                 120                 125             
Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile
    130                 135                 140                 
Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp
145                 150                 155                 160 
Ala Val Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val
                165                 170                 175     
Asn Gln Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser
            180                 185                 190         
Thr Ser Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe
        195                 200                 205             
Arg Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys
    210                 215                 220                 
Ile Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser
225                 230                 235                 240 
Tyr Phe Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys
                245                 250                 255     
Gln Met Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro
            260                 265                 270         
Val Phe Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe
        275                 280                 285             
Val Gly Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val
    290                 295                 300                 
Met Glu Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln
305                 310                 315                 320 
Glu Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys
                325                 330                 335     
Tyr Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg
            340                 345                 350         
Pro Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser
        355                 360                 365             
Tyr Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg
    370                 375                 380                 
Ile His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile
385                 390                 395                 400 
Asp Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala
                405                 410                 415     
Pro Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu
            420                 425                 430         
Phe Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp
        435                 440                 445             
Pro Lys Arg Leu Thr Pro Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu
    450                 455                 460                 
Leu Gly Leu Asp Ser Thr His His His His His His
465                 470                 475     


<210> 64
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 64
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Pro Ser Ala Ser Ala Ser Arg Lys Ser
            20                  25                  30          
Gln Glu Lys Pro Arg Glu Ile Met Asp Ala Ala Glu Asp Trp Asn Glu
        35                  40                  45              
Leu Leu Cys Cys Phe Trp Asp Cys Ile Met Phe Val Arg Pro Pro Cys
    50                  55                  60                  
Ser Leu Val Ile Pro Asn Asp Ser Leu Leu Lys Phe Thr Leu Cys His
65                  70                  75                  80  
Leu Thr Pro Val Trp Met Thr Glu Arg Asp Pro Ala Ser Lys Lys Lys
                85                  90                  95      
Lys Lys Lys Glu Ser His Thr Tyr Ser Phe Gln Leu Glu
            100                 105                 


<210> 65
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 65
Met Gly Ser Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro
 1               5                  10                  15      
Arg Glu Ile Met Asp Ala Ala Glu Asp Trp Asn Glu Leu Leu Cys Cys
            20                  25                  30          
Phe Trp Asp Cys Ile Met Phe Val Arg Pro Pro Cys Ser Leu Val Ile
        35                  40                  45              
Pro Asn Asp Ser Leu Leu Lys Phe Thr Leu Cys His Leu Thr Pro Val
    50                  55                  60                  
Trp Met Thr Glu Arg Asp Pro Ala Ser Lys Lys Lys Lys Lys Lys Glu
65                  70                  75                  80  
Ser His Thr Tyr Ser Phe Gln Leu Glu Gly Lys Pro Ile Pro Asn Pro
                85                  90                  95      
Leu Leu Gly Leu Asp Ser Thr His His His His His His
            100                 105                 


<210> 66
<211> 831
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized aspartyl tRNA synthetase
      polynucleotide

<400> 66
ggatccccat cagcctcagc atctcgtaaa agccaggaaa aaccgcgcga aatcatggac 60
gctgccgaag attatgccaa agagcgctat ggtatcagtt cgatgatcca gtcacaagag 120
aaaccagatc gtgtgctggt ccgtgttcgt gacctgacca tccagaaagc ggatgaagtt 180
gtttgggtcc gtgctcgtgt tcatacaagc cgtgccaaag gcaaacagtg cttcctggtt 240
ctgcgtcaac agcagtttaa cgttcaggcc ctggtagccg ttggtgatca cgcctcaaaa 300
caaatggtga aattcgccgc caacatcaac aaagagagca tcgtcgacgt tgaaggtgtc 360
gtccgtaaag tgaatcagaa aatcggctcc tgtacacagc aagatgtgga gctgcatgtc 420
caaaaaatct atgtcatctc actggccgaa cctcgtctgc ctctgcaact ggatgatgct 480
gtacgccctg aagctgaagg cgaagaagaa ggtcgtgcta cggttaatca ggatactcgc 540
ctggacaacc gtgtcattga tctgcgcacc tcaacctctc aagcggtatt ccgcctgcaa 600
tccggcatct gtcacctgtt ccgtgaaacg ctgatcaaca aagggtttgt ggagattcag 660
accccgaaaa tcattagtgc cgccagcgaa ggtggagcaa atgtgtttac cgtgtcctat 720
ttcaaaaaca atgcctatct ggcacagtct cctcagctgt ataaacaaat gtgtatctgt 780
gctgacttcg agaaagtgtt ctcaatcggg ccggtattcc gtgcactcga g          831

<210> 67
<211> 681
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized aspartyl tRNA synthetase
      polynucleotide

<400> 67
ggatccccat cagcctcagc atctcgtaaa agccaggaaa aaccgcgcga aatcatggac 60
gctgccgaag attatgccaa agagcgctat ggtatcagtt cgatgatcca gtcacaagag 120
aaaccagatc gtgtgctggt ccgtgttcgt gacctgacca tccagaaagc ggatgaagtt 180
gtttgggtcc gtgctcgtgt tcatacaagc cgtgccaaag gcaaacagtg cttcctggtt 240
ctgcgtcaac agcagtttaa cgttcaggcc ctggtagccg ttggtgatca cgcctcaaaa 300
caaatggtga aattcgccgc caacatcaac aaagagagca tcgtcgacgt tgaaggtgtc 360
gtccgtaaag tgaatcagaa aatcggctcc tgtacacagc aagatgtgga gctgcatgtc 420
caaaaaatct atgtcatctc actggccgaa cctcgtctgc ctctgcaact ggatgatgct 480
gtacgccctg aagctgaagg cgaagaagaa ggtcgtgcta cggttaatca ggatactcgc 540
ctggacaacc gtgtcattga tctgcgcacc tcaacctctc aagcggtatt ccgcctgcaa 600
tccggcatct gtcacctgtt ccgtgaaacg ctgatcaaca aagggtttgt ggagattcag 660
accccgaaaa tcattctcga g                                           681

<210> 68
<211> 561
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized aspartyl tRNA synthetase
      polynucleotide

<400> 68
ggatccccat cagcctcagc atctcgtaaa agccaggaaa aaccgcgcga aatcatggac 60
gctgccgaag attatgccaa agagcgctat ggtatcagtt cgatgatcca gtcacaagag 120
aaaccagatc gtgtgctggt ccgtgttcgt gacctgacca tccagaaagc ggatgaagtt 180
gtttgggtcc gtgctcgtgt tcatacaagc cgtgccaaag gcaaacagtg cttcctggtt 240
ctgcgtcaac agcagtttaa cgttcaggcc ctggtagccg ttggtgatca cgcctcaaaa 300
caaatggtga aattcgccgc caacatcaac aaagagagca tcgtcgacgt tgaaggtgtc 360
gtccgtaaag tgaatcagaa aatcggctcc tgtacacagc aagatgtgga gctgcatgtc 420
caaaaaatct atgtcatctc actggccgaa cctcgtctgc ctctgcaact ggatgatgct 480
gtacgccctg aagctgaagg cgaagaagaa ggtcgtgcta cggttaatca ggatactcgc 540
ctggacaacc gtgtcctcga g                                           561

<210> 69
<211> 1419
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized aspartyl tRNA synthetase
      polynucleotide

<400> 69
ggatccccat cagcctcagc atctcgtaaa agccaggaaa aaccgcgcga aatcatggac 60
gctgccgaag attatgccaa agagcgctat ggtatcagtt cgatgatcca gtcacaagag 120
aaaccaggca aacagtgctt cctggttctg cgtcaacagc agtttaacgt tcaggccctg 180
gtagccgttg gtgatcacgc ctcaaaacaa atggtgaaat tcgccgccaa catcaacaaa 240
gagagcatcg tcgacgttga aggtgtcgtc cgtaaagtga atcagaaaat cggctcctgt 300
acacagcaag atgtggagct gcatgtccaa aaaatctatg tcatctcact ggccgaacct 360
cgtctgcctc tgcaactgga tgatgctgta cgccctgaag ctgaaggcga agaagaaggt 420
cgtgctacgg ttaatcagga tactcgcctg gacaaccgtg tcattgatct gcgcacctca 480
acctctcaag cggtattccg cctgcaatcc ggcatctgtc acctgttccg tgaaacgctg 540
atcaacaaag ggtttgtgga gattcagacc ccgaaaatca ttagtgccgc cagcgaaggt 600
ggagcaaatg tgtttaccgt gtcctatttc aaaaacaatg cctatctggc acagtctcct 660
cagctgtata aacaaatgtg tatctgtgct gacttcgaga aagtgttctc aatcgggccg 720
gtattccgtg cagaggatag caacacacac cgccatctga ccgaatttgt aggcctggac 780
atcgaaatgg ccttcaacta tcattatcac gaggtgatgg aagaaatcgc tgatacaatg 840
gtacagatct ttaaagggct gcaagaacgc tttcaaacag agattcaaac cgtcaataaa 900
cagttcccgt gtgaaccgtt caaatttctg gaaccgaccc tgcgtctgga atattgtgaa 960
gcactggcta tgctgcgcga agctggtgtc gaaatgggtg atgaggatga cctgtctacc 1020
cctaacgaaa aactgctggg ccacctggta aaagaaaaat atgacacaga cttctatatc 1080
ctggacaaat atccgctggc agttcgtccg ttttatacga tgcctgatcc tcgtaatccg 1140
aaacaaagca actcctatga catgttcatg cgtggtgaag agatcctgtc tggtgctcaa 1200
cgtatccatg atccacagct gctgacagaa cgtgcactgc atcacggtat tgatctggag 1260
aaaatcaaag cctatatcga ctcctttcgc tttggtgccc ctccacatgc cggtggtgga 1320
attgggctgg agcgtgtaac aatgctgttc ctgggactgc acaacgtccg tcaaacctca 1380
atgtttccac gtgaccctaa acgtctgaca cctctcgag                        1419

<210> 70
<211> 1371
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized aspartyl tRNA synthetase
      polynucleotide

<400> 70
ggatccccat cagcctcagc atctcgtaaa agccaggaaa aaccgcgcga aatcatggac 60
gctgccgaag attatgccaa agagcgctat ggtatcagtt cgatgatcca gtcacaagag 120
aaaccagatc gtgtgctggt ccgtgttcgt gacctgacca tccagaaagc ggatgaagtt 180
gtttgggtcc gtgctcgtgt tcatacaagc cgtgccaaag gcaaacagtg cttcctggtt 240
ctgcgtcaac agcagtttaa cgttcaggcc ctggtagccg ttggtgatca cgcctcaaaa 300
caaatggtga aattcgccgc caacatcaac aaagagagca tcgtcgacgt tgaaggtgtc 360
gtccgtaaag tgaatcagaa aatcggctcc tgtacacagc aagatgtgga gctgcatgtc 420
caaaaaacct caacctctca agcggtattc cgcctgcaat ccggcatctg tcacctgttc 480
cgtgaaacgc tgatcaacaa agggtttgtg gagattcaga ccccgaaaat cattagtgcc 540
gccagcgaag gtggagcaaa tgtgtttacc gtgtcctatt tcaaaaacaa tgcctatctg 600
gcacagtctc ctcagctgta taaacaaatg tgtatctgtg ctgacttcga gaaagtgttc 660
tcaatcgggc cggtattccg tgcagaggat agcaacacac accgccatct gaccgaattt 720
gtaggcctgg acatcgaaat ggccttcaac tatcattatc acgaggtgat ggaagaaatc 780
gctgatacaa tggtacagat ctttaaaggg ctgcaagaac gctttcaaac agagattcaa 840
accgtcaata aacagttccc gtgtgaaccg ttcaaatttc tggaaccgac cctgcgtctg 900
gaatattgtg aagcactggc tatgctgcgc gaagctggtg tcgaaatggg tgatgaggat 960
gacctgtcta cccctaacga aaaactgctg ggccacctgg taaaagaaaa atatgacaca 1020
gacttctata tcctggacaa atatccgctg gcagttcgtc cgttttatac gatgcctgat 1080
cctcgtaatc cgaaacaaag caactcctat gacatgttca tgcgtggtga agagatcctg 1140
tctggtgctc aacgtatcca tgatccacag ctgctgacag aacgtgcact gcatcacggt 1200
attgatctgg agaaaatcaa agcctatatc gactcctttc gctttggtgc ccctccacat 1260
gccggtggtg gaattgggct ggagcgtgta acaatgctgt tcctgggact gcacaacgtc 1320
cgtcaaacct caatgtttcc acgtgaccct aaacgtctga cacctctcga g          1371

<210> 71
<211> 1365
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized aspartyl tRNA synthetase
      polynucleotide

<400> 71
ggatccccat cagcctcagc atctcgtaaa agccaggaaa aaccgcgcga aatcatggac 60
gctgccgaag attatgccaa agagcgctat ggtatcagtt cgatgatcca gtcacaagag 120
aaaccagatc gtgtgctggt ccgtgttcgt gacctgacca tccagaaagc ggatgaagtt 180
gtttgggtcc gtgctcgtgt tcatacaagc cgtgccaaag gcaaacagtg cttcctggtt 240
ctgcgtcaac agcagtttaa cgttcaggcc ctggtagccg ttggtgatca cgcctcaaaa 300
caaatggtga aattcgccgc caacatcaac aaagagagca tcgtcgacgt tgaaggtgtc 360
gtccgtaaag tgaatcagaa aatcggctcc tgtacacagc aagatgtgga gctgcatgtc 420
caaaaaatct atgtcatctc actggccgaa cctcgtctgc ctctgcaact ggatgatgct 480
gtacgccctg aagctgaagg cgaagaagaa ggtcgtgcta cggttaatca ggatactcgc 540
ctggacaacc gtgtcattga tctgcgcacc tcaacctctc aagcggtatt ccgcctgcaa 600
tccggcatct gtcacctgtt ccgtgaaacg ctgatcaaca aagggtttgt ggagattcag 660
accccgaaaa tcattagtgc cgccagcgaa ggtggagcaa atgtgtttac cgtgtcctat 720
ttcaaaaaca atgcctatct ggcacagtct cctcagctgt ataaacaaat gtgtatctgt 780
gctgacttcg agaaagtgtt ctcaatcggg ccggtattcc gtgcagagga tagcaacaca 840
caccgccatc tgaccgaatt tgtaggcctg gacatcgaaa tggccttcaa ctatcattat 900
cacgaggtga tggaagaaat cgctgataca atggtacaga tctttaaagg gctgcaagaa 960
tctaccccta acgaaaaact gctgggccac ctggtaaaag aaaaatatga cacagacttc 1020
tatatcctgg acaaatatcc gctggcagtt cgtccgtttt atacgatgcc tgatcctcgt 1080
aatccgaaac aaagcaactc ctatgacatg ttcatgcgtg gtgaagagat cctgtctggt 1140
gctcaacgta tccatgatcc acagctgctg acagaacgtg cactgcatca cggtattgat 1200
ctggagaaaa tcaaagccta tatcgactcc tttcgctttg gtgcccctcc acatgccggt 1260
ggtggaattg ggctggagcg tgtaacaatg ctgttcctgg gactgcacaa cgtccgtcaa 1320
acctcaatgt ttccacgtga ccctaaacgt ctgacacctc tcgag                 1365

<210> 72
<211> 264
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized aspartyl tRNA synthetase
      polynucleotide

<400> 72
ggatccccat cagcctcagc atctcgtaaa agccaggaaa aaccgcgcga aatcatggac 60
gctgccgaag attggaatga actgctgtgc tgcttctggg attgtatcat gttcgtacgc 120
ccgccttgtt ctctggttat cccgaacgat agcctgctga aattcaccct gtgtcatctg 180
acccctgttt ggatgactga acgtgatccg gcaagcaaaa aaaaaaaaaa aaaagagtct 240
cacacctatt cctttcaact cgag                                        264

<210> 73
<211> 401
<212> PRT
<213> Homo sapiens

<400> 73
Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile Val Asp Val
 1               5                  10                  15      
Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser Cys Thr Gln
            20                  25                  30          
Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val Ile Ser Leu Ala
        35                  40                  45              
Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val Arg Pro Glu Ala
    50                  55                  60                  
Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln Asp Thr Arg Leu
65                  70                  75                  80  
Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser Gln Ala Val Phe
                85                  90                  95      
Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu Thr Leu Ile Asn
            100                 105                 110         
Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile Ser Ala Ala Ser
        115                 120                 125             
Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe Lys Asn Asn Ala
    130                 135                 140                 
Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met Cys Ile Cys Ala
145                 150                 155                 160 
Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe Arg Ala Glu Asp
                165                 170                 175     
Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly Leu Asp Ile Glu
            180                 185                 190         
Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu Glu Ile Ala Asp
        195                 200                 205             
Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg Phe Gln Thr Glu
    210                 215                 220                 
Ile Gln Thr Val Asn Lys Gln Phe Pro Cys Glu Pro Phe Lys Phe Leu
225                 230                 235                 240 
Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala Leu Ala Met Leu Arg
                245                 250                 255     
Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu Ser Thr Pro Asn
            260                 265                 270         
Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr Asp Thr Asp Phe
        275                 280                 285             
Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro Phe Tyr Thr Met
    290                 295                 300                 
Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr Asp Met Phe Met
305                 310                 315                 320 
Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile His Asp Pro Gln
                325                 330                 335     
Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp Leu Glu Lys Ile
            340                 345                 350         
Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro Pro His Ala Gly
        355                 360                 365             
Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe Leu Gly Leu His
    370                 375                 380                 
Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro Lys Arg Leu Thr
385                 390                 395                 400 
Pro
    


<210> 74
<211> 1206
<212> DNA
<213> Homo sapiens

<400> 74
atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg 60
agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag 120
aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt 180
cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta 240
gacaacagag tcattgatct taggacatca actagtcagg cagtcttccg tctccagtct 300
ggcatctgcc atctcttccg agaaacttta attaacaaag gttttgtgga aatccaaact 360
cctaaaatta tttcagctgc cagtgaagga ggagccaatg tttttactgt gtcatatttt 420
aaaaataatg catacctggc tcagtcccca cagctatata agcaaatgtg catttgtgct 480
gattttgaga aggttttctc tattggacca gtattcagag cggaagactc taatacccat 540
agacatctaa ctgagtttgt tggtttggac attgaaatgg cttttaatta ccattaccac 600
gaagttatgg aagaaattgc tgacaccatg gtacaaatat tcaaaggact tcaagaaagg 660
tttcagactg aaattcaaac agtgaataaa cagttcccat gtgagccatt caaatttttg 720
gagccaactc taagactaga atattgtgaa gcattggcta tgcttaggga agctggagtc 780
gaaatgggag atgaagacga tctgagcaca ccaaatgaaa agctgttggg tcatttggta 840
aaggaaaagt atgatacaga tttttatatt cttgataaat atccattggc tgtaagacct 900
ttctatacca tgcctgaccc aagaaatccc aaacagtcca actcttacga tatgttcatg 960
agaggagaag aaatattgtc aggagctcaa agaatacatg atcctcaact gctaacagag 1020
agagctttac atcatggaat tgatttggag aaaattaagg cttacattga ttccttccgc 1080
tttggagccc ctcctcatgc tggtggaggc attggattgg aacgagttac tatgctgttt 1140
ctgggattgc ataatgttcg tcagacctcc atgttccctc gtgatcccaa acgactcact 1200
ccttaa                                                            1206

<210> 75
<211> 24
<212> PRT
<213> Homo sapiens

<400> 75
Met Leu Phe Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro
 1               5                  10                  15      
Arg Asp Pro Lys Arg Leu Thr Pro
            20                  


<210> 76
<211> 75
<212> DNA
<213> Homo sapiens

<400> 76
atgctgtttc tgggattgca taatgttcgt cagacctcca tgttccctcg tgatcccaaa 60
cgactcactc cttaa                                                  75

<210> 77
<211> 50
<212> DNA
<213> Homo sapiens

<400> 77
gcgggagatc atggacgcgg cggaaatcga gttttggttc gggttagaga            50

<210> 78
<211> 50
<212> DNA
<213> Homo sapiens

<400> 78
gcgggagatc atggacgcgg cggaagattg gaacgagtta ctatgctgtt            50

<210> 79
<211> 2
<212> PRT
<213> Homo sapiens

<400> 79
Met Leu
 1      


<210> 80
<211> 205
<212> PRT
<213> Homo sapiens

<400> 80
Tyr His Tyr His Glu Val Met Glu Glu Ile Ala Asp Thr Met Val Gln
 1               5                  10                  15      
Ile Phe Lys Gly Leu Gln Glu Arg Phe Gln Thr Glu Ile Gln Thr Val
            20                  25                  30          
Asn Lys Gln Phe Pro Cys Glu Pro Phe Lys Phe Leu Glu Pro Thr Leu
        35                  40                  45              
Arg Leu Glu Tyr Cys Glu Ala Leu Ala Met Leu Arg Glu Ala Gly Val
    50                  55                  60                  
Glu Met Gly Asp Glu Asp Asp Leu Ser Thr Pro Asn Glu Lys Leu Leu
65                  70                  75                  80  
Gly His Leu Val Lys Glu Lys Tyr Asp Thr Asp Phe Tyr Ile Leu Asp
                85                  90                  95      
Lys Tyr Pro Leu Ala Val Arg Pro Phe Tyr Thr Met Pro Asp Pro Arg
            100                 105                 110         
Asn Pro Lys Gln Ser Asn Ser Tyr Asp Met Phe Met Arg Gly Glu Glu
        115                 120                 125             
Ile Leu Ser Gly Ala Gln Arg Ile His Asp Pro Gln Leu Leu Thr Glu
    130                 135                 140                 
Arg Ala Leu His His Gly Ile Asp Leu Glu Lys Ile Lys Ala Tyr Ile
145                 150                 155                 160 
Asp Ser Phe Arg Phe Gly Ala Pro Pro His Ala Gly Gly Gly Ile Gly
                165                 170                 175     
Leu Glu Arg Val Thr Met Leu Phe Leu Gly Leu His Asn Val Arg Gln
            180                 185                 190         
Thr Ser Met Phe Pro Arg Asp Pro Lys Arg Leu Thr Pro
        195                 200                 205 


<210> 81
<211> 618
<212> DNA
<213> Homo sapiens

<400> 81
taccattacc acgaagttat ggaagaaatt gctgacacca tggtacaaat attcaaagga 60
cttcaagaaa ggtttcagac tgaaattcaa acagtgaata aacagttccc atgtgagcca 120
ttcaaatttt tggagccaac tctaagacta gaatattgtg aagcattggc tatgcttagg 180
gaagctggag tcgaaatggg agatgaagac gatctgagca caccaaatga aaagctgttg 240
ggtcatttgg taaaggaaaa gtatgataca gatttttata ttcttgataa atatccattg 300
gctgtaagac ctttctatac catgcctgac ccaagaaatc ccaaacagtc caactcttac 360
gatatgttca tgagaggaga agaaatattg tcaggagctc aaagaataca tgatcctcaa 420
ctgctaacag agagagcttt acatcatgga attgatttgg agaaaattaa ggcttacatt 480
gattccttcc gctttggagc ccctcctcat gctggtggag gcattggatt ggaacgagtt 540
actatgctgt ttctgggatt gcataatgtt cgtcagacct ccatgttccc tcgtgatccc 600
aaacgactca ctccttaa                                               618

<210> 82
<211> 230
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 82
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Tyr His Tyr His Glu Val Met Glu Glu
            20                  25                  30          
Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg Phe
        35                  40                  45              
Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Cys Glu Pro Phe
    50                  55                  60                  
Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala Leu Ala
65                  70                  75                  80  
Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu Ser
                85                  90                  95      
Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr Asp
            100                 105                 110         
Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro Phe
        115                 120                 125             
Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr Asp
    130                 135                 140                 
Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile His
145                 150                 155                 160 
Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp Leu
                165                 170                 175     
Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro Pro
            180                 185                 190         
His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe Leu
        195                 200                 205             
Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro Lys
    210                 215                 220                 
Arg Leu Thr Pro Leu Glu
225                 230 


<210> 83
<211> 230
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 83
Met Gly Ser Tyr His Tyr His Glu Val Met Glu Glu Ile Ala Asp Thr
 1               5                  10                  15      
Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg Phe Gln Thr Glu Ile
            20                  25                  30          
Gln Thr Val Asn Lys Gln Phe Pro Cys Glu Pro Phe Lys Phe Leu Glu
        35                  40                  45              
Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala Leu Ala Met Leu Arg Glu
    50                  55                  60                  
Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu Ser Thr Pro Asn Glu
65                  70                  75                  80  
Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr Asp Thr Asp Phe Tyr
                85                  90                  95      
Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro Phe Tyr Thr Met Pro
            100                 105                 110         
Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr Asp Met Phe Met Arg
        115                 120                 125             
Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile His Asp Pro Gln Leu
    130                 135                 140                 
Leu Thr Glu Arg Ala Leu His His Gly Ile Asp Leu Glu Lys Ile Lys
145                 150                 155                 160 
Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro Pro His Ala Gly Gly
                165                 170                 175     
Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe Leu Gly Leu His Asn
            180                 185                 190         
Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro Lys Arg Leu Thr Pro
        195                 200                 205             
Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr
    210                 215                 220                 
His His His His His His
225                 230 


<210> 84
<211> 425
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 84
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Val Lys Phe Ala Ala Asn Ile Asn Lys
            20                  25                  30          
Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys
        35                  40                  45              
Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile
    50                  55                  60                  
Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp
65                  70                  75                  80  
Ala Val Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val
                85                  90                  95      
Asn Gln Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser
            100                 105                 110         
Thr Ser Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe
        115                 120                 125             
Arg Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys
    130                 135                 140                 
Ile Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser
145                 150                 155                 160 
Tyr Phe Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys
                165                 170                 175     
Gln Met Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro
            180                 185                 190         
Val Phe Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe
        195                 200                 205             
Val Gly Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val
    210                 215                 220                 
Met Glu Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln
225                 230                 235                 240 
Glu Arg Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Cys
                245                 250                 255     
Glu Pro Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu
            260                 265                 270         
Ala Leu Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp
        275                 280                 285             
Asp Leu Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu
    290                 295                 300                 
Lys Tyr Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val
305                 310                 315                 320 
Arg Pro Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn
                325                 330                 335     
Ser Tyr Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln
            340                 345                 350         
Arg Ile His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly
        355                 360                 365             
Ile Asp Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly
    370                 375                 380                 
Ala Pro Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met
385                 390                 395                 400 
Leu Phe Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg
                405                 410                 415     
Asp Pro Lys Arg Leu Thr Pro Leu Glu
            420                 425 


<210> 85
<211> 425
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 85
Met Gly Ser Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile Val
 1               5                  10                  15      
Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser Cys
            20                  25                  30          
Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val Ile Ser
        35                  40                  45              
Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val Arg Pro
    50                  55                  60                  
Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln Asp Thr
65                  70                  75                  80  
Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser Gln Ala
                85                  90                  95      
Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu Thr Leu
            100                 105                 110         
Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile Ser Ala
        115                 120                 125             
Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe Lys Asn
    130                 135                 140                 
Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met Cys Ile
145                 150                 155                 160 
Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe Arg Ala
                165                 170                 175     
Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly Leu Asp
            180                 185                 190         
Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu Glu Ile
        195                 200                 205             
Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg Phe Gln
    210                 215                 220                 
Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Cys Glu Pro Phe Lys
225                 230                 235                 240 
Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala Leu Ala Met
                245                 250                 255     
Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu Ser Thr
            260                 265                 270         
Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr Asp Thr
        275                 280                 285             
Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro Phe Tyr
    290                 295                 300                 
Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr Asp Met
305                 310                 315                 320 
Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile His Asp
                325                 330                 335     
Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp Leu Glu
            340                 345                 350         
Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro Pro His
        355                 360                 365             
Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe Leu Gly
    370                 375                 380                 
Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro Lys Arg
385                 390                 395                 400 
Leu Thr Pro Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu
                405                 410                 415     
Asp Ser Thr His His His His His His
            420                 425 


<210> 86
<211> 627
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized aspartyl tRNA synthetase
      polynucleotide

<400> 86
ggatcctatc attatcacga ggtgatggaa gaaatcgctg atacaatggt acagatcttt 60
aaagggctgc aagaacgctt tcaaacagag attcaaaccg tcaataaaca gttcccgtgt 120
gaaccgttca aatttctgga accgaccctg cgtctggaat attgtgaagc actggctatg 180
ctgcgcgaag ctggtgtcga aatgggtgat gaggatgacc tgtctacccc taacgaaaaa 240
ctgctgggcc acctggtaaa agaaaaatat gacacagact tctatatcct ggacaaatat 300
ccgctggcag ttcgtccgtt ttatacgatg cctgatcctc gtaatccgaa acaaagcaac 360
tcctatgaca tgttcatgcg tggtgaagag atcctgtctg gtgctcaacg tatccatgat 420
ccacagctgc tgacagaacg tgcactgcat cacggtattg atctggagaa aatcaaagcc 480
tatatcgact cctttcgctt tggtgcccct ccacatgccg gtggtggaat tgggctggag 540
cgtgtaacaa tgctgttcct gggactgcac aacgtccgtc aaacctcaat gtttccacgt 600
gaccctaaac gtctgacacc tctcgag                                     627

<210> 87
<211> 1212
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized aspartyl tRNA synthetase
      polynucleotide

<400> 87
ggatccgtga aattcgccgc caacatcaac aaagagagca tcgtcgacgt tgaaggtgtc 60
gtccgtaaag tgaatcagaa aatcggctcc tgtacacagc aagatgtgga gctgcatgtc 120
caaaaaatct atgtcatctc actggccgaa cctcgtctgc ctctgcaact ggatgatgct 180
gtacgccctg aagctgaagg cgaagaagaa ggtcgtgcta cggttaatca ggatactcgc 240
ctggacaacc gtgtcattga tctgcgcacc tcaacctctc aagcggtatt ccgcctgcaa 300
tccggcatct gtcacctgtt ccgtgaaacg ctgatcaaca aagggtttgt ggagattcag 360
accccgaaaa tcattagtgc cgccagcgaa ggtggagcaa atgtgtttac cgtgtcctat 420
ttcaaaaaca atgcctatct ggcacagtct cctcagctgt ataaacaaat gtgtatctgt 480
gctgacttcg agaaagtgtt ctcaatcggg ccggtattcc gtgcagagga tagcaacaca 540
caccgccatc tgaccgaatt tgtaggcctg gacatcgaaa tggccttcaa ctatcattat 600
cacgaggtga tggaagaaat cgctgataca atggtacaga tctttaaagg gctgcaagaa 660
cgctttcaaa cagagattca aaccgtcaat aaacagttcc cgtgtgaacc gttcaaattt 720
ctggaaccga ccctgcgtct ggaatattgt gaagcactgg ctatgctgcg cgaagctggt 780
gtcgaaatgg gtgatgagga tgacctgtct acccctaacg aaaaactgct gggccacctg 840
gtaaaagaaa aatatgacac agacttctat atcctggaca aatatccgct ggcagttcgt 900
ccgttttata cgatgcctga tcctcgtaat ccgaaacaaa gcaactccta tgacatgttc 960
atgcgtggtg aagagatcct gtctggtgct caacgtatcc atgatccaca gctgctgaca 1020
gaacgtgcac tgcatcacgg tattgatctg gagaaaatca aagcctatat cgactccttt 1080
cgctttggtg cccctccaca tgccggtggt ggaattgggc tggagcgtgt aacaatgctg 1140
ttcctgggac tgcacaacgt ccgtcaaacc tcaatgtttc cacgtgaccc taaacgtctg 1200
acacctctcg ag                                                     1212

<210> 88
<211> 255
<212> PRT
<213> Homo sapiens

<400> 88
Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val Arg Asp Leu Thr Ile
 1               5                  10                  15      
Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala Arg Val His Thr Ser
            20                  25                  30          
Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu Arg Gln Gln Gln Phe
        35                  40                  45              
Asn Val Gln Ala Leu Val Ala Val Gly Asp His Ala Ser Lys Gln Met
    50                  55                  60                  
Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile Val Asp Val Glu
65                  70                  75                  80  
Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln
                85                  90                  95      
Asp Val Glu Leu His Val Gln Lys Ile Tyr Val Ile Ser Leu Ala Glu
            100                 105                 110         
Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val Arg Pro Glu Ala Glu
        115                 120                 125             
Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln Asp Thr Arg Leu Asp
    130                 135                 140                 
Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser Gln Ala Val Phe Arg
145                 150                 155                 160 
Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu Thr Leu Ile Asn Lys
                165                 170                 175     
Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile Ser Ala Ala Ser Glu
            180                 185                 190         
Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe Lys Asn Asn Ala Tyr
        195                 200                 205             
Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met Cys Ile Cys Ala Asp
    210                 215                 220                 
Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe Arg Ala Glu Asp Ser
225                 230                 235                 240 
Asn Thr His Arg His Leu Thr Glu Phe Val Gly Leu Asp Ile Glu
                245                 250                 255 


<210> 89
<211> 765
<212> DNA
<213> Homo sapiens

<400> 89
caagaaaaac cagatcgagt tttggttcgg gttagagact tgacaataca aaaagctgat 60
gaagttgttt gggtacgtgc aagagttcat acaagcagag ctaaagggaa acagtgcttc 120
ttagtcctac gtcagcagca gtttaatgtc caggctcttg tggcggtggg agaccatgca 180
agcaagcaga tggttaaatt tgctgccaac atcaacaaag agagcattgt ggatgtagaa 240
ggtgttgtga gaaaagtgaa tcagaaaatt ggaagctgta cacagcaaga cgttgagtta 300
catgttcaga agatttatgt gatcagtttg gctgaacccc gtctgcccct gcagctggat 360
gatgctgttc ggcctgaggc agaaggagaa gaggaaggaa gagctactgt taaccaggat 420
acaagattag acaacagagt cattgatctt aggacatcaa ctagtcaggc agtcttccgt 480
ctccagtctg gcatctgcca tctcttccga gaaactttaa ttaacaaagg ttttgtggaa 540
atccaaactc ctaaaattat ttcagctgcc agtgaaggag gagccaatgt ttttactgtg 600
tcatatttta aaaataatgc atacctggct cagtccccac agctatataa gcaaatgtgc 660
atttgtgctg attttgagaa ggttttctct attggaccag tattcagagc ggaagactct 720
aatacccata gacatctaac tgagtttgtt ggtttggaca ttgaa                 765

<210> 90
<211> 15
<212> PRT
<213> Mus musculus

<400> 90
Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys
 1               5                  10                  15  


<210> 91
<211> 10
<212> PRT
<213> Mus musculus

<400> 91
Ile Tyr Val Ile Ser Leu Ala Glu Pro Arg
 1               5                  10  


<210> 92
<211> 20
<212> PRT
<213> Mus musculus

<400> 92
Leu Pro Leu Gln Leu Asp Asp Ala Ile Arg Pro Glu Val Glu Gly Glu
 1               5                  10                  15      
Glu Asp Gly Arg
            20  


<210> 93
<211> 54
<212> PRT
<213> Mus musculus

<400> 93
Ala Thr Val Asn Gln Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu
 1               5                  10                  15      
Arg Thr Ser Thr Ser Gln Ala Ile Phe Arg Leu Gln Ser Gly Ile Cys
            20                  25                  30          
His Leu Phe Arg Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln
        35                  40                  45              
Thr Pro Lys Ile Ile Ser
    50                  


<210> 94
<211> 16
<212> PRT
<213> Mus musculus

<400> 94
Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe Lys
 1               5                  10                  15      


<210> 95
<211> 115
<212> PRT
<213> Mus musculus

<400> 95
Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile
 1               5                  10                  15      
Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp
            20                  25                  30          
Ala Ile Arg Pro Glu Val Glu Gly Glu Glu Asp Gly Arg Ala Thr Val
        35                  40                  45              
Asn Gln Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser
    50                  55                  60                  
Thr Ser Gln Ala Ile Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe
65                  70                  75                  80  
Arg Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys
                85                  90                  95      
Ile Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser
            100                 105                 110         
Tyr Phe Lys
        115 


<210> 96
<211> 132
<212> PRT
<213> Homo sapiens

<400> 96
Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser Ser Met Ile Gln Ser Gln
 1               5                  10                  15      
Glu Lys Pro Asp Arg Val Leu Val Arg Val Arg Asp Leu Thr Ile Gln
            20                  25                  30          
Lys Ala Asp Glu Val Val Trp Val Arg Ala Arg Val His Thr Ser Arg
        35                  40                  45              
Ala Lys Gly Lys Gln Cys Phe Leu Val Leu Arg Gln Gln Gln Phe Asn
    50                  55                  60                  
Val Gln Ala Leu Val Ala Val Gly Asp His Ala Ser Lys Gln Met Val
65                  70                  75                  80  
Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile Val Asp Val Glu Gly
                85                  90                  95      
Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln Asp
            100                 105                 110         
Val Glu Leu His Val Gln Lys Ile Tyr Val Ile Ser Leu Ala Glu Pro
        115                 120                 125             
Arg Leu Pro Leu
    130         


<210> 97
<211> 396
<212> DNA
<213> Homo sapiens

<400> 97
gattatgcta aagagagata tggaatatct tcaatgatac aatcacaaga aaaaccagat 60
cgagttttgg ttcgggttag agacttgaca atacaaaaag ctgatgaagt tgtttgggta 120
cgtgcaagag ttcatacaag cagagctaaa gggaaacagt gcttcttagt cctacgtcag 180
cagcagttta atgtccaggc tcttgtggcg gtgggagacc atgcaagcaa gcagatggtt 240
aaatttgctg ccaacatcaa caaagagagc attgtggatg tagaaggtgt tgtgagaaaa 300
gtgaatcaga aaattggaag ctgtacacag caagacgttg agttacatgt tcagaagatt 360
tatgtgatca gtttggctga accccgtctg cccctg                           396

<210> 98
<211> 122
<212> PRT
<213> Homo sapiens

<400> 98
Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val
 1               5                  10                  15      
Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala
            20                  25                  30          
Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu
        35                  40                  45              
Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His
    50                  55                  60                  
Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser
65                  70                  75                  80  
Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly
                85                  90                  95      
Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val
            100                 105                 110         
Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu
        115                 120         


<210> 99
<211> 366
<212> DNA
<213> Homo sapiens

<400> 99
tcaatgatac aatcacaaga aaaaccagat cgagttttgg ttcgggttag agacttgaca 60
atacaaaaag ctgatgaagt tgtttgggta cgtgcaagag ttcatacaag cagagctaaa 120
gggaaacagt gcttcttagt cctacgtcag cagcagttta atgtccaggc tcttgtggcg 180
gtgggagacc atgcaagcaa gcagatggtt aaatttgctg ccaacatcaa caaagagagc 240
attgtggatg tagaaggtgt tgtgagaaaa gtgaatcaga aaattggaag ctgtacacag 300
caagacgttg agttacatgt tcagaagatt tatgtgatca gtttggctga accccgtctg 360
cccctg                                                            366

<210> 100
<211> 280
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag
      

<400> 100
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Gln Glu Lys Pro Asp Arg Val Leu Val
            20                  25                  30          
Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val
        35                  40                  45              
Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu
    50                  55                  60                  
Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly
65                  70                  75                  80  
Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys
                85                  90                  95      
Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys
            100                 105                 110         
Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile
        115                 120                 125             
Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp
    130                 135                 140                 
Ala Val Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val
145                 150                 155                 160 
Asn Gln Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser
                165                 170                 175     
Thr Ser Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe
            180                 185                 190         
Arg Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys
        195                 200                 205             
Ile Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser
    210                 215                 220                 
Tyr Phe Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys
225                 230                 235                 240 
Gln Met Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro
                245                 250                 255     
Val Phe Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe
            260                 265                 270         
Val Gly Leu Asp Ile Glu Leu Glu
        275                 280 


<210> 101
<211> 280
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag
      

<400> 101
Met Gly Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val Arg Asp
 1               5                  10                  15      
Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala Arg Val
            20                  25                  30          
His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu Arg Gln
        35                  40                  45              
Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His Ala Ser
    50                  55                  60                  
Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile Val
65                  70                  75                  80  
Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser Cys
                85                  90                  95      
Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val Ile Ser
            100                 105                 110         
Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val Arg Pro
        115                 120                 125             
Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln Asp Thr
    130                 135                 140                 
Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser Gln Ala
145                 150                 155                 160 
Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu Thr Leu
                165                 170                 175     
Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile Ser Ala
            180                 185                 190         
Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe Lys Asn
        195                 200                 205             
Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met Cys Ile
    210                 215                 220                 
Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe Arg Ala
225                 230                 235                 240 
Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly Leu Asp
                245                 250                 255     
Ile Glu Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp
            260                 265                 270         
Ser Thr His His His His His His
        275                 280 


<210> 102
<211> 147
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag
      

<400> 102
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ser Met Ile Gln Ser Gln Glu Lys Pro
            20                  25                  30          
Asp Arg Val Leu Val Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp
        35                  40                  45              
Glu Val Val Trp Val Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly
    50                  55                  60                  
Lys Gln Cys Phe Leu Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala
65                  70                  75                  80  
Leu Val Ala Val Gly Asp His Ala Ser Lys Gln Met Val Lys Phe Ala
                85                  90                  95      
Ala Asn Ile Asn Lys Glu Ser Ile Val Asp Val Glu Gly Val Val Arg
            100                 105                 110         
Lys Val Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu
        115                 120                 125             
His Val Gln Lys Ile Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro
    130                 135                 140                 
Leu Leu Glu
145         


<210> 103
<211> 147
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspartyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag
      

<400> 103
Met Gly Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu
 1               5                  10                  15      
Val Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp
            20                  25                  30          
Val Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe
        35                  40                  45              
Leu Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val
    50                  55                  60                  
Gly Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn
65                  70                  75                  80  
Lys Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln
                85                  90                  95      
Lys Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys
            100                 105                 110         
Ile Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Leu Glu Gly
        115                 120                 125             
Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His
    130                 135                 140                 
His His His
145         


<210> 104
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized aspartyl tRNA synthetase
      polynucleotide

<400> 104
ggatcccaag agaaaccaga tcgtgtgctg gtccgtgttc gtgacctgac catccagaaa 60
gcggatgaag ttgtttgggt ccgtgctcgt gttcatacaa gccgtgccaa aggcaaacag 120
tgcttcctgg ttctgcgtca acagcagttt aacgttcagg ccctggtagc cgttggtgat 180
cacgcctcaa aacaaatggt gaaattcgcc gccaacatca acaaagagag catcgtcgac 240
gttgaaggtg tcgtccgtaa agtgaatcag aaaatcggct cctgtacaca gcaagatgtg 300
gagctgcatg tccaaaaaat ctatgtcatc tcactggccg aacctcgtct gcctctgcaa 360
ctggatgatg ctgtacgccc tgaagctgaa ggcgaagaag aaggtcgtgc tacggttaat 420
caggatactc gcctggacaa ccgtgtcatt gatctgcgca cctcaacctc tcaagcggta 480
ttccgcctgc aatccggcat ctgtcacctg ttccgtgaaa cgctgatcaa caaagggttt 540
gtggagattc agaccccgaa aatcattagt gccgccagcg aaggtggagc aaatgtgttt 600
accgtgtcct atttcaaaaa caatgcctat ctggcacagt ctcctcagct gtataaacaa 660
atgtgtatct gtgctgactt cgagaaagtg ttctcaatcg ggccggtatt ccgtgcagag 720
gatagcaaca cacaccgcca tctgaccgaa tttgtaggcc tggacatcga actcgag    777

<210> 105
<211> 378
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized aspartyl tRNA synthetase
      polynucleotide

<400> 105
ggatcctcga tgatccagtc acaagagaaa ccagatcgtg tgctggtccg tgttcgtgac 60
ctgaccatcc agaaagcgga tgaagttgtt tgggtccgtg ctcgtgttca tacaagccgt 120
gccaaaggca aacagtgctt cctggttctg cgtcaacagc agtttaacgt tcaggccctg 180
gtagccgttg gtgatcacgc ctcaaaacaa atggtgaaat tcgccgccaa catcaacaaa 240
gagagcatcg tcgacgttga aggtgtcgtc cgtaaagtga atcagaaaat cggctcctgt 300
acacagcaag atgtggagct gcatgtccaa aaaatctatg tcatctcact ggccgaacct 360
cgtctgcctc tgctcgag                                               378
