                         SEQUENCE LISTING

<110>  OPKO CURNA LLC
 
<120>  TREATMENT OF DISCS LARGE HOMOLOG (DLG) RELATED DISEASES BY 
       INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO DLG

<130>  DLG

<150>  61/364,211
<151>  2010-07-14

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  5034
<212>  DNA
<213>  Homo sapiens

<400>  1
gttggaaacg gcactgctga gtgaggttga ggggtgtctc ggtatgtgcg ccttggatct       60

ggtgtaggcg aggtcacgcc tctcttcaga cagcccgagc cttcccggcc tggcgcgttt      120

agttcggaac tgcgggacgc gccggtgggc tagggcaagg tgtgtgccct cttcctgatt      180

ctggagaaaa atgccggtcc ggaagcaaga tacccagaga gcattgcacc ttttggagga      240

atatcgttca aaactaagcc aaactgaaga cagacagctc agaagttcca tagaacgggt      300

tattaacata tttcagagca acctctttca ggctttaata gatattcaag aattttatga      360

agtgacctta ctggataatc caaaatgtat agatcgttca aagccgtctg aaccaattca      420

acctgtgaat acttgggaga tttccagcct tccaagctct actgtgactt cagagacact      480

gccaagcagc cttagcccta gtgtagagaa atacaggtat caggatgaag atacacctcc      540

tcaagagcat atttccccac aaatcacaaa tgaagtgata ggtccagaat tggttcatgt      600

ctcagagaag aacttatcag agattgagaa tgtccatgga tttgtttctc attctcatat      660

ttcaccaata aagccaacag aagctgttct tccctctcct cccactgtcc ctgtgatccc      720

tgtcctgcca gtccctgctg agaatactgt catcctaccc accataccac aggcaaatcc      780

tcccccagta ctggtcaaca cagatagctt ggaaacacca acttacgtta atggcacaga      840

tgcagattat gaatatgaag aaatcacact tgaaagggga aattcagggc ttggtttcag      900

cattgcagga ggtacggaca acccacacat tggagatgac tcaagtattt tcattaccaa      960

aattatcaca gggggagcag ccgcccaaga tggaagattg cgggtcaatg actgtatatt     1020

acgagtaaat gaagtagatg ttcgtgatgt aacacatagc aaagcagttg aagcgttgaa     1080

agaagcaggg tctattgtac gcttgtatgt aaaaagaagg aaaccagtgt cagaaaaaat     1140

aatggaaata aagctcatta aaggtcctaa aggtcttggg tttagcattg ctggaggtgt     1200

tggaaatcag catattcctg gggataatag catctatgta accaaaataa ttgaaggagg     1260

tgcagcacat aaggatggca aacttcagat tggagataaa cttttagcag tgaataacgt     1320

atgtttagaa gaagttactc atgaagaagc agtaactgcc ttaaagaaca catctgattt     1380

tgtttatttg aaagtggcaa aacccacaag tatgtatatg aatgatggct atgcaccacc     1440

tgatatcacc aactcttctt ctcagcctgt tgataaccat gttagcccat cttccttctt     1500

gggccagaca ccagcatctc cagccagata ctccccagtt tctaaagcag tacttggaga     1560

tgatgaaatt acaagggaac ctagaaaagt tgttcttcat cgtggctcaa cgggccttgg     1620

tttcaacatt gtaggaggag aagatggaga aggaatattt atttccttta tcttagccgg     1680

aggacctgct gatctaagtg gagagctcag aaaaggagat cgtattatat cggtaaacag     1740

tgttgacctc agagctgcta gtcatgagca ggcagcagct gcattgaaaa atgctggcca     1800

ggctgtcaca attgttgcac aatatcgacc tgaagaatac agtcgttttg aagctaaaat     1860

acatgattta cgggagcaga tgatgaatag tagtattagt tcagggtcag gttctcttcg     1920

aactagccag aagcgatccc tctatgtcag agcccttttt gattatgaca agactaaaga     1980

cagtgggctt cccagtcagg gactgaactt caaatttgga gatatcctcc atgttattaa     2040

tgcttctgat gatgaatggt ggcaagccag gcaggttaca ccagatggtg agagcgatga     2100

ggtcggagtg attcccagta aacgcagagt tgagaagaaa gaacgagccc gattaaaaac     2160

agtgaaattc aattctaaaa cgagagataa agggcagtca ttcaatgaca agcgtaaaaa     2220

gaacctcttt tcccgaaaat tccccttcta caagaacaag gaccagagtg agcaggaaac     2280

aagtgatgct gaccagcatg taacttctaa tgccagcgat agtgaaagta gttaccgtgg     2340

tcaagaagaa tacgtcttat cttatgaacc agtgaatcaa caagaagtta attatactcg     2400

accagtgatc atattgggac ctatgaaaga caggataaat gatgacttga tctcagaatt     2460

tcctgacaaa tttggatcct gtgttcctca tacaactaga ccaaaacgag attatgaggt     2520

agatggaaga gattatcatt ttgtgacttc aagagagcag atggaaaaag atatccagga     2580

acataaattc attgaagctg gccagtataa caatcatcta tatggaacaa gtgttcagtc     2640

tgtacgagaa gtagcagaaa agggcaaaca ctgtatcctt gatgtgtctg gaaatgccat     2700

aaagagatta cagattgcac agctttaccc tatctccatt tttattaaac ccaaatccat     2760

ggaaaatatc atggaaatga ataagcgtct aacagaagaa caagccagaa aaacatttga     2820

gagagccatg aaactggaac aggagtttac tgaacatttc acagctattg tacaggggga     2880

tacgctggaa gacatttaca accaagtgaa acagatcata gaagaacaat ctggttctta     2940

catctgggtt ccggcaaaag aaaagctatg aaaactcatg tttctctgtt tctcttttcc     3000

acaattccat tttctttggc atctctttgc cctttcctct ggagtctttc ttgagtactg     3060

atttcatgtt gaattgtatc ccacacatca tggtctgcag cttctttttc acatgtagtg     3120

tctccttcaa gttacatcgt gtgtattatt taatgtcact attggttagt ggccattttt     3180

cagaactgaa gatggaatgg cctgaccagc tattaagaac gtggggagac gcagaaattg     3240

tggtaaaatt ccttaatgtt taagggaaag taactttaag agatttttgg aaaagcttta     3300

tatacattct tttcaaattt cagtacaaat gaaaaagtgg ttttaatcag tgatttagta     3360

gactttgagc aactgtgcac gcttcagttt aatagcatgg tttggccagt gtattactct     3420

caagtccttt tctcaatcaa cttctatcat caaagcaatt gtttcattat agataaataa     3480

ggacattttt taatttaaaa attcatgtct gagttgactt tcataaggga tttcattttt     3540

tcctcaacat tcttaaagcc ttttagtatt tgacggttct tttttcccag gacatttgct     3600

aggaataaca acgtttcaat gtttttaatc tacttgagca acactatcgt gtcttacaaa     3660

agttgttcat atgtaaatga tcatcacatt tcgtgaattg aggccatgtt caggtgctaa     3720

ggaagttcgc cttttacaca gaagattgag aaaatttcct agatataaat acagataaat     3780

cagacgttac agtggtgacg tagtaaccat catggcaatg gaaaggagtc caattcatag     3840

cctaaaactt caaatgtatt cttaggagtc agattttact gaatatttta cccacaatag     3900

ctgcctattt tgttataata aaatatatat aaatatatat ataaaacttt ctttaaactg     3960

taactatggg aattattttc tttacatagt tgcgcacaca cacaaacata tatatatatt     4020

taaaatatat tttgtttctt ttgccaccta ctcctaactt tttgtttggt ttttaaatta     4080

aatattaatt gaatagactt atcttcctta atcatgtgaa ctgaaaatgg gggcatggtg     4140

gtcatgagga ggaaacattt agggaaatta gattataagt aaaagtgtgg gcatattctc     4200

ctcttttcta caaaggtttt caaatggttc ctgaggtttt ttgttgttgt ccgtgttgtt     4260

actgttgttc ttgtcatcag gtttgatttt ggtccttgcc ctttccttct agttctcctt     4320

ttattaatag gaaggcaggc aaaagcccca tttatgtgtg tgttttcccc tcagacagct     4380

ttcatccact gctctgcact agaattgcac aaatcttcat ggtgagcaat tttaagaaat     4440

gttagtgaaa ggtagaaatt atttcacaaa tcagtttctc tggtccttca tattaataat     4500

aatatttggc ttcccattgc tctttggagt tgtttattaa atatgtgttt ttgacaacct     4560

cctcattagt ttcttaaatg agtactggtt tgtaaagaat tatcaacatt atccattcca     4620

tttatgaaga agaggagaac agctaataaa ctgtattgta aaatccatat gttaagtgtg     4680

tcttgaattt tgaaagaaaa aatatatttt gcaagctaac attttcttga aacaatttga     4740

ggcatcatgt aacttataac cgaatccaag agccgttagg cagcagagtg tgttaccaca     4800

ttgaaataca cagtgctgct gttagactaa atgtcgtagg ttgttaacca catagaaaca     4860

cactagtatg aagaaaactg ttgtaaaatc tcaagagctt cagaaactgc cttacaagac     4920

cgcagcataa gctattttga agtatttacc aaatagtcac atgttgtaaa atatcaagtg     4980

gttataaaag gatgccattt atatattaaa atttacataa cattgttttc tgga           5034


<210>  2
<211>  1706
<212>  DNA
<213>  Homo sapiens

<400>  2
gaggcgggtc gggggagggc aggggaacgg aaggggtacc cggggagcat cctaagggaa       60

cctcttcgct taaaagggcg gccgctgaag tggctctgag aacaaaggag ttaacactcg      120

gactccacag gtggcccggg gtggccctgg aggagcccgc ctttaccttg ccctagccca      180

ccggcgcgtc ccgcagttcc gaactaaacg cgccaggccg ggaaggctcg ggctgtctga      240

agagaggcgt gacctcgcct acaccagatc caaggcgcac ataccgagac acccctcaac      300

ctcactcagc agtgccgttt ccaactccgc ggcagagaca gcgcctggcg accacggggc      360

ctgcgtcccc gcccggtcag catcgcaggt gttacccaaa ctctgacggt ccctttaaga      420

actcacccgg agtcgcgccc tccgaagctg agccgccctc ggccagcgct gcaggcccca      480

gcttataaat ctatgaaggt gtccaggtcc tgccagactc cgctgcatct tttgctttca      540

ctccagcagg gtagcagcat gctgcctgtg ccaaggcaat cactaaaagg aaaggattta      600

atgctgtcaa aaaagcttat gccagcttag gctgcaggaa gaggaacagt gtcaagtatg      660

ttgaaagtgg acatattggt cagacctcca tgagagccta gggggcattg cttagcagca      720

cgcttttaaa ggaatctgaa caaaccagca tgtggaaaga agagagtaac cacagcaatc      780

aggaaacaac tgtacaatct agggccattt cattggaaaa acagaagtct ccagggagct      840

gcagccatca aacaggctta ttctgtgtac ccagtgggca agtacagtca atggatgaaa      900

attcaaccaa tggacaaaca caggaagttt ttccttaaca tgagttgtca gaaactgtcc      960

aaaattccaa agagctgcct caaggtagtg gaaatttttt ttttttttta atcaggaagg     1020

tgctgaatga agccagcaag gattctgtgt cagagggtgg tagataccca ggacataagg     1080

ttgaaccacg tgacctctga gaccacagtt ctaagctgtt gaaacctcag tccctgctga     1140

atactgaaat ggtattagca ccctttagtc tacatcaaga attcgttcta cccagttttg     1200

gtggtaccaa gactgatctc tttctcatag ataattctta acagaataaa agctacaggt     1260

tgaaaccaat tccctttaaa atgtggacag ttgaccatct ccatgatagg tagttaggca     1320

ctgaattaat gctttttaat ggaagagcca ccctaagatt cctggagtgt ggtataatgg     1380

agtactaaat cagcatagga ctaataactg cctcccgtgt aaactggtct atccggagag     1440

tggtatagcc tctcatacag tgttcaaagg cagatttaac tcactgcagg tccacagcaa     1500

ccgataagat aaactcgttg gttatggtct cccactttgc aaaggagagc acagaggaag     1560

aggaaactga gataacttgg tttaggaccc catagctggc tggagctggg ctgaacatta     1620

gttcattgtt tcttcgatta atctatgctg ctttttctct acttggctcc ttttctaaat     1680

taaacaaaac aaaaaaaaaa aaaaaa                                          1706


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  3
ctcctttgtt ctcagagcca c                                                 21


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  4
ggatctggtg taggcgaggt                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  5
ctgctgagtg aggttgaggg                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  6
agggaccgtc agagtttggg                                                   20


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  7
cgggtgagtt cttaaaggga c                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  8
gtaacacctg cgatgctgac c                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  9
cctcttcctc tgtgctctcc t                                                 21


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  10
actctcttct ttccacatgc                                                   20


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  11
ctccattata ccacactcca g                                                 21


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  12
gtatctacca ccctctgaca                                                   20


