                         SEQUENCE LISTING

<110>  Philadelphia Health and Education Corporation d/b/a Drexel 
       University College of Medicine
       The Babraham Institute
       Katsikis, Peter
       Boesteanu, Alina
       Turner, Martin
 
<120>  The Role of PI3K p110 delta Signaling in Retroviral Infection and
        Replication

<130>  46528-6006-01-WO

<150>  US 12/835,474
<151>  2010-07-13

<150>  PCT/US10/20768
<151>  2010-01-12

<150>  61/144,262
<151>  2009-01-13

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  1044
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Pro Gly Val Asp Cys Pro Met Glu Phe Trp Thr Lys Glu Glu 
1               5                   10                  15      


Asn Gln Ser Val Val Val Asp Phe Leu Leu Pro Thr Gly Val Tyr Leu 
            20                  25                  30          


Asn Phe Pro Val Ser Arg Asn Ala Asn Leu Ser Thr Ile Lys Gln Leu 
        35                  40                  45              


Leu Trp His Arg Ala Gln Tyr Glu Pro Leu Phe His Met Leu Ser Gly 
    50                  55                  60                  


Pro Glu Ala Tyr Val Phe Thr Cys Ile Asn Gln Thr Ala Glu Gln Gln 
65                  70                  75                  80  


Glu Leu Glu Asp Glu Gln Arg Arg Leu Cys Asp Val Gln Pro Phe Leu 
                85                  90                  95      


Pro Val Leu Arg Leu Val Ala Arg Glu Gly Asp Arg Val Lys Lys Leu 
            100                 105                 110         


Ile Asn Ser Gln Ile Ser Leu Leu Ile Gly Lys Gly Leu His Glu Phe 
        115                 120                 125             


Asp Ser Leu Cys Asp Pro Glu Val Asn Asp Phe Arg Ala Lys Met Cys 
    130                 135                 140                 


Gln Phe Cys Glu Glu Ala Ala Ala Arg Arg Gln Gln Leu Gly Trp Glu 
145                 150                 155                 160 


Ala Trp Leu Gln Tyr Ser Phe Pro Leu Gln Leu Glu Pro Ser Ala Gln 
                165                 170                 175     


Thr Trp Gly Pro Gly Thr Leu Arg Leu Pro Asn Arg Ala Leu Leu Val 
            180                 185                 190         


Asn Val Lys Phe Glu Gly Ser Glu Glu Ser Phe Thr Phe Gln Val Ser 
        195                 200                 205             


Thr Lys Asp Val Pro Leu Ala Leu Met Ala Cys Ala Leu Arg Lys Lys 
    210                 215                 220                 


Ala Thr Val Phe Arg Gln Pro Leu Val Glu Gln Pro Glu Asp Tyr Thr 
225                 230                 235                 240 


Leu Gln Val Asn Gly Arg His Glu Tyr Leu Tyr Gly Ser Tyr Pro Leu 
                245                 250                 255     


Cys Gln Phe Gln Tyr Ile Cys Ser Cys Leu His Ser Gly Leu Thr Pro 
            260                 265                 270         


His Leu Thr Met Val His Ser Ser Ser Ile Leu Ala Met Arg Asp Glu 
        275                 280                 285             


Gln Ser Asn Pro Ala Pro Gln Val Gln Lys Pro Arg Ala Lys Pro Pro 
    290                 295                 300                 


Pro Ile Pro Ala Lys Lys Pro Ser Ser Val Ser Leu Trp Ser Leu Glu 
305                 310                 315                 320 


Gln Pro Phe Arg Ile Glu Leu Ile Gln Gly Ser Lys Val Asn Ala Asp 
                325                 330                 335     


Glu Arg Met Lys Leu Val Val Gln Ala Gly Leu Phe His Gly Asn Glu 
            340                 345                 350         


Met Leu Cys Lys Thr Val Ser Ser Ser Glu Val Ser Val Cys Ser Glu 
        355                 360                 365             


Pro Val Trp Lys Gln Arg Leu Glu Phe Asp Ile Asn Ile Cys Asp Leu 
    370                 375                 380                 


Pro Arg Met Ala Arg Leu Cys Phe Ala Leu Tyr Ala Val Ile Glu Lys 
385                 390                 395                 400 


Ala Lys Lys Ala Arg Ser Thr Lys Lys Lys Ser Lys Lys Ala Asp Cys 
                405                 410                 415     


Pro Ile Ala Trp Ala Asn Leu Met Leu Phe Asp Tyr Lys Asp Gln Leu 
            420                 425                 430         


Lys Thr Gly Glu Arg Cys Leu Tyr Met Trp Pro Ser Val Pro Asp Glu 
        435                 440                 445             


Lys Gly Glu Leu Leu Asn Pro Thr Gly Thr Val Arg Ser Asn Pro Asn 
    450                 455                 460                 


Thr Asp Ser Ala Ala Ala Leu Leu Ile Cys Leu Pro Glu Val Ala Pro 
465                 470                 475                 480 


His Pro Val Tyr Tyr Pro Ala Leu Glu Lys Ile Leu Glu Leu Gly Arg 
                485                 490                 495     


His Ser Glu Cys Val His Val Thr Glu Glu Glu Gln Leu Gln Leu Arg 
            500                 505                 510         


Glu Ile Leu Glu Arg Arg Gly Ser Gly Glu Leu Tyr Glu His Glu Lys 
        515                 520                 525             


Asp Leu Val Trp Lys Leu Arg His Glu Val Gln Glu His Phe Pro Glu 
    530                 535                 540                 


Ala Leu Ala Arg Leu Leu Leu Val Thr Lys Trp Asn Lys His Glu Asp 
545                 550                 555                 560 


Val Ala Gln Met Leu Tyr Leu Leu Cys Ser Trp Pro Glu Leu Pro Val 
                565                 570                 575     


Leu Ser Ala Leu Glu Leu Leu Asp Phe Ser Phe Pro Asp Cys His Val 
            580                 585                 590         


Gly Ser Phe Ala Ile Lys Ser Leu Arg Lys Leu Thr Asp Asp Glu Leu 
        595                 600                 605             


Phe Gln Tyr Leu Leu Gln Leu Val Gln Val Leu Lys Tyr Glu Ser Tyr 
    610                 615                 620                 


Leu Asp Cys Glu Leu Thr Lys Phe Leu Leu Asp Arg Ala Leu Ala Asn 
625                 630                 635                 640 


Arg Lys Ile Gly His Phe Leu Phe Trp His Leu Arg Ser Glu Met His 
                645                 650                 655     


Val Pro Ser Val Ala Leu Arg Phe Gly Leu Ile Leu Glu Ala Tyr Cys 
            660                 665                 670         


Arg Gly Ser Thr His His Met Lys Val Leu Met Lys Gln Gly Glu Ala 
        675                 680                 685             


Leu Ser Lys Leu Lys Ala Leu Asn Asp Phe Val Lys Leu Ser Ser Gln 
    690                 695                 700                 


Lys Thr Pro Lys Pro Gln Thr Lys Glu Leu Met His Leu Cys Met Arg 
705                 710                 715                 720 


Gln Glu Ala Tyr Leu Glu Ala Leu Ser His Leu Gln Ser Pro Leu Asp 
                725                 730                 735     


Pro Ser Thr Leu Leu Ala Glu Val Cys Val Glu Gln Cys Thr Phe Met 
            740                 745                 750         


Asp Ser Lys Met Lys Pro Leu Trp Ile Met Tyr Ser Asn Glu Glu Ala 
        755                 760                 765             


Gly Ser Gly Gly Ser Val Gly Ile Ile Phe Lys Asn Gly Asp Asp Leu 
    770                 775                 780                 


Arg Gln Asp Met Leu Thr Leu Gln Met Ile Gln Leu Met Asp Val Leu 
785                 790                 795                 800 


Trp Lys Gln Glu Gly Leu Asp Leu Arg Met Thr Pro Tyr Gly Cys Leu 
                805                 810                 815     


Pro Thr Gly Asp Arg Thr Gly Leu Ile Glu Val Val Leu Arg Ser Asp 
            820                 825                 830         


Thr Ile Ala Asn Ile Gln Leu Asn Lys Ser Asn Met Ala Ala Thr Ala 
        835                 840                 845             


Ala Phe Asn Lys Asp Ala Leu Leu Asn Trp Leu Lys Ser Lys Asn Pro 
    850                 855                 860                 


Gly Glu Ala Leu Asp Arg Ala Ile Glu Glu Phe Thr Leu Ser Cys Ala 
865                 870                 875                 880 


Gly Tyr Cys Val Ala Thr Tyr Val Leu Gly Ile Gly Asp Arg His Ser 
                885                 890                 895     


Asp Asn Ile Met Ile Arg Glu Ser Gly Gln Leu Phe His Ile Asp Phe 
            900                 905                 910         


Gly His Phe Leu Gly Asn Phe Lys Thr Lys Phe Gly Ile Asn Arg Glu 
        915                 920                 925             


Arg Val Pro Phe Ile Leu Thr Tyr Asp Phe Val His Val Ile Gln Gln 
    930                 935                 940                 


Gly Lys Thr Asn Asn Ser Glu Lys Phe Glu Arg Phe Arg Gly Tyr Cys 
945                 950                 955                 960 


Glu Arg Ala Tyr Thr Ile Leu Arg Arg His Gly Leu Leu Phe Leu His 
                965                 970                 975     


Leu Phe Ala Leu Met Arg Ala Ala Gly Leu Pro Glu Leu Ser Cys Ser 
            980                 985                 990         


Lys Asp Ile Gln Tyr Leu Lys Asp  Ser Leu Ala Leu Gly  Lys Thr Glu 
        995                 1000                 1005             


Glu Glu  Ala Leu Lys His Phe  Arg Val Lys Phe Asn  Glu Ala Leu 
    1010                 1015                 1020             


Arg Glu  Ser Trp Lys Thr Lys  Val Asn Trp Leu Ala  His Asn Val 
    1025                 1030                 1035             


Ser Lys  Asp Asn Arg Gln 
    1040                 


