                         SEQUENZ PROTOKOLL

<110>  Eberhard-Karls-Universitt Tbingen, Universittsklinikum
 
<120>  ASPP2 -Splicevariante

<130>  5402P442WO

<160>  3     

<170>  PatentIn version 3.3

<210>  1
<211>  879
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Leu Thr Leu Ala Glu Leu Gln Glu Met Ala Ser Arg Gln Gln 
1               5                   10                  15      


Gln Gln Ile Glu Ala Gln Gln Gln Leu Leu Ala Thr Lys Glu Gln Arg 
            20                  25                  30          


Leu Lys Phe Leu Lys Gln Gln Asp Gln Arg Gln Gln Gln Gln Val Ala 
        35                  40                  45              


Glu Gln Glu Lys Leu Lys Arg Leu Lys Glu Ile Ala Glu Asn Gln Glu 
    50                  55                  60                  


Ala Lys Leu Lys Lys Val Arg Ala Leu Lys Gly His Val Glu Gln Lys 
65                  70                  75                  80  


Arg Leu Ser Asn Gly Lys Leu Val Glu Glu Ile Glu Gln Met Asn Asn 
                85                  90                  95      


Leu Phe Gln Gln Lys Gln Arg Glu Leu Val Leu Ala Val Ser Lys Val 
            100                 105                 110         


Glu Glu Leu Thr Arg Gln Leu Glu Met Leu Lys Asn Gly Arg Ile Asp 
        115                 120                 125             


Ser His His Asp Asn Gln Ser Ala Val Ala Glu Leu Asp Arg Leu Tyr 
    130                 135                 140                 


Lys Glu Leu Gln Leu Arg Asn Lys Leu Asn Gln Glu Gln Asn Ala Lys 
145                 150                 155                 160 


Leu Gln Gln Gln Arg Glu Cys Leu Asn Lys Arg Asn Ser Glu Val Ala 
                165                 170                 175     


Val Met Asp Lys Arg Val Asn Glu Leu Arg Asp Arg Leu Trp Lys Lys 
            180                 185                 190         


Lys Ala Ala Leu Gln Gln Lys Glu Asn Leu Pro Val Ser Ser Asp Gly 
        195                 200                 205             


Asn Leu Pro Gln Gln Ala Ala Ser Ala Pro Ser Arg Val Ala Ala Val 
    210                 215                 220                 


Gly Pro Tyr Ile Gln Ser Ser Thr Met Pro Arg Met Pro Ser Arg Pro 
225                 230                 235                 240 


Glu Leu Leu Val Lys Pro Ala Leu Pro Asp Gly Ser Leu Val Ile Gln 
                245                 250                 255     


Ala Ser Glu Gly Pro Met Lys Ile Gln Thr Leu Pro Asn Met Arg Ser 
            260                 265                 270         


Gly Ala Ala Ser Gln Thr Lys Gly Ser Lys Ile His Pro Val Gly Pro 
        275                 280                 285             


Asp Trp Ser Pro Ser Asn Ala Asp Leu Phe Pro Ser Gln Gly Ser Ala 
    290                 295                 300                 


Ser Val Pro Gln Ser Thr Gly Asn Ala Leu Asp Gln Val Asp Asp Gly 
305                 310                 315                 320 


Glu Val Pro Leu Arg Glu Lys Glu Lys Lys Val Arg Pro Phe Ser Met 
                325                 330                 335     


Phe Asp Ala Val Asp Gln Ser Asn Ala Pro Pro Ser Phe Gly Thr Leu 
            340                 345                 350         


Arg Lys Asn Gln Ser Ser Glu Asp Ile Leu Arg Asp Ala Gln Val Ala 
        355                 360                 365             


Asn Lys Asn Val Ala Lys Val Pro Pro Pro Val Pro Thr Lys Pro Lys 
    370                 375                 380                 


Gln Ile Asn Leu Pro Tyr Phe Gly Gln Thr Asn Gln Pro Pro Ser Asp 
385                 390                 395                 400 


Ile Lys Pro Asp Gly Ser Ser Gln Gln Leu Ser Thr Val Val Pro Ser 
                405                 410                 415     


Met Gly Thr Lys Pro Lys Pro Ala Gly Gln Gln Pro Arg Val Leu Leu 
            420                 425                 430         


Ser Pro Ser Ile Pro Ser Val Gly Gln Asp Gln Thr Leu Ser Pro Gly 
        435                 440                 445             


Ser Lys Gln Glu Ser Pro Pro Ala Ala Ala Val Arg Pro Phe Thr Pro 
    450                 455                 460                 


Gln Pro Ser Lys Asp Thr Leu Leu Pro Pro Phe Arg Lys Pro Gln Thr 
465                 470                 475                 480 


Val Ala Ala Ser Ser Ile Tyr Ser Met Tyr Thr Gln Gln Gln Ala Pro 
                485                 490                 495     


Gly Lys Asn Phe Gln Gln Ala Val Gln Ser Ala Leu Thr Lys Thr His 
            500                 505                 510         


Thr Arg Gly Pro His Phe Ser Ser Val Tyr Gly Lys Pro Val Ile Ala 
        515                 520                 525             


Ala Ala Gln Asn Gln Gln Gln His Pro Glu Asn Ile Tyr Ser Asn Ser 
    530                 535                 540                 


Gln Gly Lys Pro Gly Ser Pro Glu Pro Glu Thr Glu Pro Val Ser Ser 
545                 550                 555                 560 


Val Gln Glu Asn His Glu Asn Glu Arg Ile Pro Arg Pro Leu Ser Pro 
                565                 570                 575     


Thr Lys Leu Leu Pro Phe Leu Ser Asn Pro Tyr Arg Asn Gln Ser Asp 
            580                 585                 590         


Ala Asp Leu Glu Ala Leu Arg Lys Lys Leu Ser Asn Ala Pro Arg Pro 
        595                 600                 605             


Leu Lys Lys Arg Ser Ser Ile Thr Glu Pro Glu Gly Pro Asn Gly Pro 
    610                 615                 620                 


Asn Ile Gln Lys Leu Leu Tyr Gln Arg Thr Thr Ile Ala Ala Met Glu 
625                 630                 635                 640 


Thr Ile Ser Val Pro Ser Tyr Pro Ser Lys Ser Ala Ser Val Thr Ala 
                645                 650                 655     


Ser Ser Glu Ser Pro Val Glu Ile Gln Asn Pro Tyr Leu His Val Glu 
            660                 665                 670         


Pro Glu Lys Glu Val Val Ser Leu Val Pro Glu Ser Leu Ser Pro Glu 
        675                 680                 685             


Asp Val Gly Asn Ala Ser Thr Glu Asn Ser Asp Met Pro Ala Pro Ser 
    690                 695                 700                 


Pro Gly Leu Asp Tyr Glu Pro Glu Gly Val Pro Asp Asn Ser Pro Asn 
705                 710                 715                 720 


Leu Gln Asn Asn Pro Glu Glu Pro Asn Pro Glu Ala Pro His Val Leu 
                725                 730                 735     


Asp Val Tyr Leu Glu Glu Tyr Pro Pro Tyr Pro Pro Pro Pro Tyr Pro 
            740                 745                 750         


Ser Gly Glu Pro Glu Gly Pro Gly Glu Asp Ser Val Ser Met Arg Pro 
        755                 760                 765             


Pro Glu Ile Thr Gly Gln Val Ser Leu Pro Pro Gly Lys Arg Thr Asn 
    770                 775                 780                 


Leu Arg Lys Thr Gly Ser Glu Arg Ile Ala His Gly Met Arg Val Lys 
785                 790                 795                 800 


Phe Asn Pro Leu Ala Leu Leu Leu Asp Ser Ser Leu Glu Gly Glu Phe 
                805                 810                 815     


Asp Leu Val Gln Arg Ile Ile Tyr Glu Val Asp Asp Pro Ser Leu Pro 
            820                 825                 830         


Asn Asp Glu Gly Ile Thr Ala Leu His Asn Ala Val Cys Ala Gly His 
        835                 840                 845             


Thr Glu Ile Val Lys Phe Leu Val Gln Phe Gly Val Asn Val Asn Ala 
    850                 855                 860                 


Ala Asp Ser Asp Gly Trp Ser Ser Gly Glu Asp Gly His Asn Glu 
865                 870                 875                 


<210>  2
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Ser Gly Glu Asp Gly His Asn Glu 
1               5                   


<210>  3
<211>  3451
<212>  DNA
<213>  Homo sapiens

<400>  3
gctggggccc gacccgggat tagttggttt cggagcggag gagggagccc cgaccgtcac     60

gagcgtcgaa gagacaaagc cgcgtcaggg ggcccggccg gggcggggga gcccggggct    120

tgttggtgcc ccagcccgcg cggagggccc ttcggacccg cgcgccgccg ctgccgccgc    180

cgccgcctcg caacaggtcc gggcggcctc gctctccgct cccctccccc gcatccgcga    240

ccctccgggg cacctcagct cggccggggc cgcagtctgg ccacccgctt ccatgcggtt    300

cgggtccaag atgatgccga tgtttcttac cgtgtatctc agtaacaatg agcagcactt    360

cacagaagtt ccagttactc cagaaacaat atgcagagac gtggtggatc tgtgcaaaga    420

acccggcgag agtgattgcc atttggctga agtgtggtgt ggctctgtag agatagagtt    480

tcatcatgtt ggccaggatg gtctcgatct cctgaccttg tgatccgcct gcctcggcct    540

cccaaagtgc tggattacag gtgtgagcca ccacgatcag cctctagtgt ttaaaaaaga    600

acgtccagtt gcggataatg agcgaatgtt tgatgttctt caacgatttg gaagtcagag    660

gaacgaagtt cgcttcttcc ttcgtcatga acgcccccct ggcagggaca ttgtgagtgg    720

accaagatct caggatccaa gtttaaaaag aaatggtgta aaagttcctg gtgaatatcg    780

aagaaaggag aacggtgtta atagtcctag gatggatctg actcttgctg aacttcagga    840

aatggcatct cgccagcagc aacagattga agcccagcaa caattgctgg caactaagga    900

acagcgctta aagtttttga aacaacaaga tcagcgacaa cagcaacaag ttgctgagca    960

ggagaaactt aaaaggctaa aagaaatagc tgagaatcag gaagctaagc taaaaaaagt   1020

gagagcactt aaaggccacg tggaacagaa gagactaagc aatgggaaac ttgtggagga   1080

aattgaacag atgaataatt tgttccagca aaaacagagg gagctcgtcc tggctgtgtc   1140

aaaagtagaa gaactgacca ggcagctaga gatgctcaag aacggcagga tcgacagcca   1200

ccatgacaat cagtctgcag tggctgagct tgatcgcctc tataaggagc tgcagctaag   1260

aaacaaattg aatcaagagc agaatgccaa gctacaacaa cagagggagt gtttgaataa   1320

gcgtaattca gaagtggcag tcatggataa gcgtgttaat gagctgaggg accggctgtg   1380

gaagaagaag gcagctctac agcaaaaaga aaatctacca gtttcatctg atggaaatct   1440

tccccagcaa gccgcgtcag ccccaagccg tgtggctgca gtaggtccct atatccagtc   1500

gtctactatg cctcggatgc cctcaaggcc tgaattgctg gtgaagccag ccctgccgga   1560

tggttccttg gtcattcagg cttcagaggg gccgatgaaa atacagacac tgcccaacat   1620

gagatctggg gctgcttcac aaactaaagg ctctaaaatc catccagttg gccctgattg   1680

gagtccttca aatgcagatc ttttcccaag ccaaggctct gcttctgtac ctcaaagcac   1740

tgggaatgct ctggatcaag ttgatgatgg agaggttccg ctgagggaga aagagaagaa   1800

agtgcgtccg ttctcaatgt ttgatgcagt agaccagtcc aatgccccac cttcctttgg   1860

tactctgagg aagaaccaga gcagtgaaga tatcttgcgg gatgctcagg ttgcaaataa   1920

aaatgtggct aaagtaccac ctcctgttcc tacaaaacca aaacagatta atttgcctta   1980

ttttggacaa actaatcagc caccttcaga cattaagcca gacggaagtt ctcagcagtt   2040

gtcaacagtt gttccgtcca tgggaactaa accaaaacca gcagggcagc agccgagagt   2100

gctgctatct cccagcatac cttcggttgg ccaagaccag accctttctc caggttctaa   2160

gcaagaaagt ccacctgctg ctgccgtccg gccctttact ccccagcctt ccaaagacac   2220

cttacttcca cccttcagaa aaccccagac cgtggcagca agttcaatat attccatgta   2280

tacgcaacag caggcgccag gaaaaaactt ccagcaggct gtgcagagcg cgttgaccaa   2340

gactcatacc agagggccac acttttcaag tgtatatggt aagcctgtaa ttgctgctgc   2400

ccagaatcaa cagcagcacc cagagaacat ttattccaat agccagggca agcctggcag   2460

tccagaacct gaaacagagc ctgtttcttc agttcaggag aaccatgaaa acgaaagaat   2520

tcctcggcca ctcagcccaa ctaaattact gcctttctta tctaatcctt accgaaacca   2580

gagtgatgct gacctagaag ccttacgaaa gaaactgtct aacgcaccaa ggcctctaaa   2640

gaaacgtagt tctattacag agccagaggg tcctaatggg ccaaatattc agaagctttt   2700

atatcagagg accaccatag cggccatgga gaccatctct gtcccatcat acccatccaa   2760

gtcagcttct gtgactgcca gctcagaaag cccagtagaa atccagaatc catatttaca   2820

tgtggagccc gaaaaggagg tggtctctct ggttcctgaa tcattgtccc cagaggatgt   2880

ggggaatgcc agtacagaga acagtgacat gccagctcct tctccaggcc ttgattatga   2940

gcctgaggga gtcccagaca acagcccaaa tctccagaat aacccagaag aaccaaatcc   3000

agaggctcca catgtgcttg atgtgtacct ggaggagtac cctccatacc cacccccacc   3060

atacccatct ggggagcctg aagggcccgg agaagactcg gtgagcatgc gcccgcctga   3120

aatcaccggg caggtctctc tgcctcctgg taaaaggaca aacttgcgta aaactggctc   3180

agagcgtatc gctcatggaa tgagggtgaa attcaacccc cttgctttac tgctagattc   3240

gtctttggag ggagaatttg accttgtaca gagaattatt tatgaggttg atgacccaag   3300

cctccccaat gatgaaggca tcacggctct tcacaatgct gtgtgtgcag gccacacaga   3360

aatcgttaag ttcctggtac agtttggtgt aaatgtaaat gctgctgata gtgatggatg   3420

gagttcagga gaagatgggc ataatgaata a                                  3451


