                         SEQUENCE LISTING

<110>  UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF 
       HIGHER EDUCATION
       Ross, Ted M.
       Giles, Brendan M.
 
<120>  COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR INFLUENZA

<130>  8123-85899-02

<150>  US 61/403,407
<151>  2010-09-14

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  1707
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  CDS
<222>  (1)..(1707)

<400>  1
atg gaa aag atc gtg ctg ctg ctg gct atc gtg agc ctg gtg aag agc         48
Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser           
1               5                   10                  15                

gac cag att tgc atc ggc tac cac gcc aac aac agc acc gag cag gtg         96
Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val           
            20                  25                  30                    

gac acc atc atg gaa aag aac gtc acc gtg acc cac gcc cag gac atc        144
Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile           
        35                  40                  45                        

ctg gaa aag acc cac aac ggc aag ctg tgc gac ctg gac ggc gtg aag        192
Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys           
    50                  55                  60                            

ccc ctg atc ctg agg gac tgc agc gtg gcc ggc tgg ctg ctg ggc aac        240
Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn           
65                  70                  75                  80            

ccc atg tgc gac gag ttc atc aac gtg ccc gag tgg agc tac atc gtg        288
Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val           
                85                  90                  95                

gag aag gcc aac ccc gcc aac gac ctg tgc tac ccc ggc aac ttc aac        336
Glu Lys Ala Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe Asn           
            100                 105                 110                   

gac tac gag gaa ctg aag cac ctg ctg tcc agg atc aac cac ttc gag        384
Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu           
        115                 120                 125                       

aag atc cag atc atc ccc aag agc agc tgg tcc gac cac gag gcc agc        432
Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser           
    130                 135                 140                           

agc ggc gtg agc agc gcc tgc cca tac cag ggc agc ccc agc ttc ttc        480
Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Ser Pro Ser Phe Phe           
145                 150                 155                 160           

aga aac gtg gtg tgg ctg atc aag aag aac aac acc tac ccc acc atc        528
Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asn Thr Tyr Pro Thr Ile           
                165                 170                 175               

aag agg tcc tac aac aac acc aac cag gaa gat ctg ctg gtc ctg tgg        576
Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp           
            180                 185                 190                   

ggc atc cac cac cct aat gac gcc gcc gaa cag acc agg ctg tac cag        624
Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln           
        195                 200                 205                       

aac ccc acc acc tac atc agc gtg ggc aca agc acc ctg aac cag agg        672
Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg           
    210                 215                 220                           

ctg gtg ccc aag atc gcc acc agg tcc aag gtg aac gga cag tcc ggc        720
Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly           
225                 230                 235                 240           

agg atg gaa ttc ttc tgg acc atc ctg aag cct aac gac gcc atc aac        768
Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn           
                245                 250                 255               

ttc gag agc aac ggc aac ttt atc gcc ccc gag tac gcc tac aag atc        816
Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile           
            260                 265                 270                   

gtg aag aag ggc gac agc gcc atc atg aag agc gag ctg gaa tac ggc        864
Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr Gly           
        275                 280                 285                       

aac tgc aac acc aag tgc cag acc ccc atc ggc gcc atc aac agc agc        912
Asn Cys Asn Thr Lys Cys Gln Thr Pro Ile Gly Ala Ile Asn Ser Ser           
    290                 295                 300                           

atg ccc ttc cac aac atc cac ccc ctg acc atc ggc gag tgc ccc aag        960
Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys           
305                 310                 315                 320           

tac gtg aag agc aac agg ctg gtg ctg gcc acc ggc ctg agg aac agc       1008
Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser           
                325                 330                 335               

ccc cag aga gag agc aga aga aag aag agg ggc ctg ttc ggc gct atc       1056
Pro Gln Arg Glu Ser Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile           
            340                 345                 350                   

gcc ggc ttc atc gag ggc ggc tgg cag ggc atg gtg gac ggg tgg tac       1104
Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr           
        355                 360                 365                       

ggc tac cac cac tct aac gag cag ggc agc ggc tac gcc gcc gac aaa       1152
Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys           
    370                 375                 380                           

gag agc acc cag aag gcc atc gac ggc gtc acc aac aag gtg aac agc       1200
Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser           
385                 390                 395                 400           

atc atc gac aag atg aac acc cag ttc gag gcc gtg ggc aga gag ttc       1248
Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe           
                405                 410                 415               

aac aac ctg gaa agg cgg atc gag aac ctg aac aag aaa atg gaa gat       1296
Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp           
            420                 425                 430                   

ggc ttc ctg gac gtg tgg acc tac aac gcc gag ctg ctg gtg ctg atg       1344
Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met           
        435                 440                 445                       

gaa aac gag agg acc ctg gac ttc cac gac agc aac gtg aag aac ctg       1392
Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu           
    450                 455                 460                           

tac gac aaa gtg cgg ctg cag ctg agg gac aac gcc aaa gag ctg ggc       1440
Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly           
465                 470                 475                 480           

aac ggc tgc ttc gag ttc tac cac aag tgc gac aac gag tgc atg gaa       1488
Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu           
                485                 490                 495               

agc gtg agg aac ggc acc tac gac tac ccc cag tac agc gag gaa gcc       1536
Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala           
            500                 505                 510                   

agg ctg aag agg gaa gag atc agc gga gtg aag ctg gaa agc atc ggc       1584
Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly           
        515                 520                 525                       

acc tac cag atc ctg agc atc tac agc acc gtc gcc agc agc ctg gcc       1632
Thr Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala           
    530                 535                 540                           

ctg gct atc atg gtg gcc gga ctg agc ctg tgg atg tgc agc aac ggc       1680
Leu Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly           
545                 550                 555                 560           

agc ctg cag tgc agg atc tgc atc tga                                   1707
Ser Leu Gln Cys Arg Ile Cys Ile                                           
                565                                                       


<210>  2
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Ser Pro Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asn Thr Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Ile Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Ser Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr 
        355                 360                 365             


Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys 
    370                 375                 380                 


Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser 
385                 390                 395                 400 


Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe 
                405                 410                 415     


Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp 
            420                 425                 430         


Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met 
        435                 440                 445             


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
    450                 455                 460                 


Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu 
                485                 490                 495     


Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala 
            500                 505                 510         


Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly 
        515                 520                 525             


Thr Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala 
    530                 535                 540                 


Leu Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly 
545                 550                 555                 560 


Ser Leu Gln Cys Arg Ile Cys Ile 
                565             


<210>  3
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  CDS
<222>  (1)..(1350)

<400>  3
atg aat cct aat aag aag atc atc aca atc gga agc atc tgc atg gtg         48
Met Asn Pro Asn Lys Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val           
1               5                   10                  15                

aca gga atg gtg agc ctg atg ctg cag atc gga aat ctg atc agc atc         96
Thr Gly Met Val Ser Leu Met Leu Gln Ile Gly Asn Leu Ile Ser Ile           
            20                  25                  30                    

tgg gtg agc cac agc atc cac aca gga aat cag cac aag gcc gag cct        144
Trp Val Ser His Ser Ile His Thr Gly Asn Gln His Lys Ala Glu Pro           
        35                  40                  45                        

atc agc aat aca aat ttt ctg aca gag aag gcc gtg gcc agc gtg aag        192
Ile Ser Asn Thr Asn Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys           
    50                  55                  60                            

ctg gcc gga aat agc agc ctg tgc cct atc aat gga tgg gcc gtg tac        240
Leu Ala Gly Asn Ser Ser Leu Cys Pro Ile Asn Gly Trp Ala Val Tyr           
65                  70                  75                  80            

agc aag gat aat agc atc aga atc gga agc aag gga gat gtg ttt gtg        288
Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly Asp Val Phe Val           
                85                  90                  95                

atc aga gag cct ttt atc agc tgc agc cac ctg gag tgc aga aca ttt        336
Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu Cys Arg Thr Phe           
            100                 105                 110                   

ttt ctg aca cag gga gcc ctg ctg aat gat aag cac agc aat gga aca        384
Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly Thr           
        115                 120                 125                       

gtg aag gat aga agc cct cac aga aca ctg atg agc tgc cct gtg gga        432
Val Lys Asp Arg Ser Pro His Arg Thr Leu Met Ser Cys Pro Val Gly           
    130                 135                 140                           

gag gcc cct agc cct tac aat agc aga ttt gag agc gtg gcc tgg agc        480
Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp Ser           
145                 150                 155                 160           

gcc agc gcc tgc cac gat gga aca agc tgg ctg aca atc gga atc agc        528
Ala Ser Ala Cys His Asp Gly Thr Ser Trp Leu Thr Ile Gly Ile Ser           
                165                 170                 175               

gga cct gat aat gga gcc gtg gcc gtg ctg aag tac aat gga atc atc        576
Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile Ile           
            180                 185                 190                   

aca gat aca atc aag agc tgg aga aat aat atc ctg aga aca cag gag        624
Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln Glu           
        195                 200                 205                       

agc gag tgc gcc tgc gtg aat gga agc tgc ttt aca gtg atg aca gat        672
Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Val Met Thr Asp           
    210                 215                 220                           

gga cct agc aat gga cag gcc agc cac aag atc ttt aag atg gag aag        720
Gly Pro Ser Asn Gly Gln Ala Ser His Lys Ile Phe Lys Met Glu Lys           
225                 230                 235                 240           

gga aag gtg gtg aag agc gtg gag ctg gat gcc cct aat tac cac tac        768
Gly Lys Val Val Lys Ser Val Glu Leu Asp Ala Pro Asn Tyr His Tyr           
                245                 250                 255               

gag gag tgc agc tgc tac cct gat gcc gga gag atc aca tgc gtg tgc        816
Glu Glu Cys Ser Cys Tyr Pro Asp Ala Gly Glu Ile Thr Cys Val Cys           
            260                 265                 270                   

aga gat aat tgg cac gga agc aat aga cct tgg gtg agc ttt aat cag        864
Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn Gln           
        275                 280                 285                       

aat ctg gag tac cag atc gga tac atc tgc agc gga gtg ttt gga gat        912
Asn Leu Glu Tyr Gln Ile Gly Tyr Ile Cys Ser Gly Val Phe Gly Asp           
    290                 295                 300                           

aat cct aga cct aat gat gga aca gga agc tgc gga cct gtg agc agc        960
Asn Pro Arg Pro Asn Asp Gly Thr Gly Ser Cys Gly Pro Val Ser Ser           
305                 310                 315                 320           

aat gga gcc tac gga gtg aag gga ttt agc ttt aag tac gga aat gga       1008
Asn Gly Ala Tyr Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn Gly           
                325                 330                 335               

gtg tgg atc gga aga aca aag agc aca aat agc aga agc gga ttt gag       1056
Val Trp Ile Gly Arg Thr Lys Ser Thr Asn Ser Arg Ser Gly Phe Glu           
            340                 345                 350                   

atg atc tgg gac cct aat gga tgg aca gag aca gat agc agc ttt agc       1104
Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr Asp Ser Ser Phe Ser           
        355                 360                 365                       

gtg aag cag gat atc gtg gcc atc aca gat tgg agc gga tac agc gga       1152
Val Lys Gln Asp Ile Val Ala Ile Thr Asp Trp Ser Gly Tyr Ser Gly           
    370                 375                 380                           

agc ttt gtg cag cac cct gag ctg aca gga ctg gat tgc atc aga cct       1200
Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg Pro           
385                 390                 395                 400           

tgc ttt tgg gtg gag ctg atc aga gga aga cct aag gag agc aca atc       1248
Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Lys Glu Ser Thr Ile           
                405                 410                 415               

tgg aca agc gga agc agc atc agc ttt tgc gga gtg aat agc gat aca       1296
Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp Thr           
            420                 425                 430                   

gtg gga tgg agc tgg cct gat gga gcc gag ctg cct ttt aca atc gat       1344
Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile Asp           
        435                 440                 445                       

aag tga                                                               1350
Lys                                                                       
                                                                          


<210>  4
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Asn Pro Asn Lys Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val 
1               5                   10                  15      


Thr Gly Met Val Ser Leu Met Leu Gln Ile Gly Asn Leu Ile Ser Ile 
            20                  25                  30          


Trp Val Ser His Ser Ile His Thr Gly Asn Gln His Lys Ala Glu Pro 
        35                  40                  45              


Ile Ser Asn Thr Asn Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys 
    50                  55                  60                  


Leu Ala Gly Asn Ser Ser Leu Cys Pro Ile Asn Gly Trp Ala Val Tyr 
65                  70                  75                  80  


Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly Asp Val Phe Val 
                85                  90                  95      


Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu Cys Arg Thr Phe 
            100                 105                 110         


Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly Thr 
        115                 120                 125             


Val Lys Asp Arg Ser Pro His Arg Thr Leu Met Ser Cys Pro Val Gly 
    130                 135                 140                 


Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp Ser 
145                 150                 155                 160 


Ala Ser Ala Cys His Asp Gly Thr Ser Trp Leu Thr Ile Gly Ile Ser 
                165                 170                 175     


Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile Ile 
            180                 185                 190         


Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln Glu 
        195                 200                 205             


Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Val Met Thr Asp 
    210                 215                 220                 


Gly Pro Ser Asn Gly Gln Ala Ser His Lys Ile Phe Lys Met Glu Lys 
225                 230                 235                 240 


Gly Lys Val Val Lys Ser Val Glu Leu Asp Ala Pro Asn Tyr His Tyr 
                245                 250                 255     


Glu Glu Cys Ser Cys Tyr Pro Asp Ala Gly Glu Ile Thr Cys Val Cys 
            260                 265                 270         


Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn Gln 
        275                 280                 285             


Asn Leu Glu Tyr Gln Ile Gly Tyr Ile Cys Ser Gly Val Phe Gly Asp 
    290                 295                 300                 


Asn Pro Arg Pro Asn Asp Gly Thr Gly Ser Cys Gly Pro Val Ser Ser 
305                 310                 315                 320 


Asn Gly Ala Tyr Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn Gly 
                325                 330                 335     


Val Trp Ile Gly Arg Thr Lys Ser Thr Asn Ser Arg Ser Gly Phe Glu 
            340                 345                 350         


Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr Asp Ser Ser Phe Ser 
        355                 360                 365             


Val Lys Gln Asp Ile Val Ala Ile Thr Asp Trp Ser Gly Tyr Ser Gly 
    370                 375                 380                 


Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg Pro 
385                 390                 395                 400 


Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Lys Glu Ser Thr Ile 
                405                 410                 415     


Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp Thr 
            420                 425                 430         


Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile Asp 
        435                 440                 445             


Lys 
    


<210>  5
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  CDS
<222>  (1)..(759)

<400>  5
atg agc ctg ctg acc gag gtg gag aca tac gtg ctg tcc atc atc ccc         48
Met Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro           
1               5                   10                  15                

agc ggc cct ctg aag gcc gag atc gcc cag aga ctg gaa gat gtg ttc         96
Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe           
            20                  25                  30                    

gcc ggc aag aac acc gac ctg gaa gtg ctg atg gaa tgg ctg aaa acc        144
Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr           
        35                  40                  45                        

aga ccc atc ctg agc cct ctg acc aag ggc atc ctg ggc ttc gtg ttc        192
Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe           
    50                  55                  60                            

acc ctg acc gtg ccc agc gag aga ggc ctg cag agg cgg aga ttc gtg        240
Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val           
65                  70                  75                  80            

cag aac gcc ctg aac ggc aac ggc gac ccc aac aac atg gac aag gcc        288
Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala           
                85                  90                  95                

gtg aag ctg tac aga aag ctg aag cgg gag atc acc ttc cac ggc gcc        336
Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala           
            100                 105                 110                   

aaa gag atc agc ctg agc tac agc gct ggc gcc ctg gcc agc tgc atg        384
Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met           
        115                 120                 125                       

ggc ctg atc tac aac aga atg ggc gcc gtg acc acc gag gtg gcc ttc        432
Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe           
    130                 135                 140                           

ggc ctg gtc tgc gcc acc tgc gag cag atc gcc gac agc cag cac aga        480
Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg           
145                 150                 155                 160           

tcc cac aga cag atg gtc acc acc acc aac ccc ctg atc aga cac gag        528
Ser His Arg Gln Met Val Thr Thr Thr Asn Pro Leu Ile Arg His Glu           
                165                 170                 175               

aac aga atg gtg ctg gcc tct acc acc gcc aag gcc atg gaa cag atg        576
Asn Arg Met Val Leu Ala Ser Thr Thr Ala Lys Ala Met Glu Gln Met           
            180                 185                 190                   

gcc ggc agc agc gag cag gcc gcc gag gct atg gaa gtc gcc tct cag        624
Ala Gly Ser Ser Glu Gln Ala Ala Glu Ala Met Glu Val Ala Ser Gln           
        195                 200                 205                       

gct agg cag atg gtc cag gcc atg aga acc atc ggc acc cac ccc agc        672
Ala Arg Gln Met Val Gln Ala Met Arg Thr Ile Gly Thr His Pro Ser           
    210                 215                 220                           

agc tct gct ggc ctg aag aac gac ctg ctg gaa aac ctg cag gcc tac        720
Ser Ser Ala Gly Leu Lys Asn Asp Leu Leu Glu Asn Leu Gln Ala Tyr           
225                 230                 235                 240           

cag aaa aga atg ggc gtc cag atg cag aga ttc aag tga                    759
Gln Lys Arg Met Gly Val Gln Met Gln Arg Phe Lys                           
                245                 250                                   


<210>  6
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro 
1               5                   10                  15      


Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe 
            20                  25                  30          


Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr 
        35                  40                  45              


Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe 
    50                  55                  60                  


Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val 
65                  70                  75                  80  


Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala 
                85                  90                  95      


Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala 
            100                 105                 110         


Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met 
        115                 120                 125             


Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe 
    130                 135                 140                 


Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg 
145                 150                 155                 160 


Ser His Arg Gln Met Val Thr Thr Thr Asn Pro Leu Ile Arg His Glu 
                165                 170                 175     


Asn Arg Met Val Leu Ala Ser Thr Thr Ala Lys Ala Met Glu Gln Met 
            180                 185                 190         


Ala Gly Ser Ser Glu Gln Ala Ala Glu Ala Met Glu Val Ala Ser Gln 
        195                 200                 205             


Ala Arg Gln Met Val Gln Ala Met Arg Thr Ile Gly Thr His Pro Ser 
    210                 215                 220                 


Ser Ser Ala Gly Leu Lys Asn Asp Leu Leu Glu Asn Leu Gln Ala Tyr 
225                 230                 235                 240 


Gln Lys Arg Met Gly Val Gln Met Gln Arg Phe Lys 
                245                 250         


<210>  7
<211>  5511
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7
cgacaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta       60

tattggctca tgtccaatat gaccgccatg ttgacattga ttattgacta gttattaata      120

gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact      180

tacggtaaat ggcccgcctc gtgaccgccc aacgaccccc gcccattgac gtcaataatg      240

acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat      300

ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag tccgccccta      360

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttacggg      420

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt      480

tttggcagta caccaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc      540

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat      600

gtcgtaataa ccccgccccg ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct      660

atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt      720

ttgacctcca tagaagacac cgggaccgat ccagcctccg cggccgggaa cggtgcattg      780

gaacgcggat tccccgtgcc aagagtgacg taagtaccgc ctatagactc tataggcaca      840

cccctttggc tcttatgcat gctatactgt ttttggcttg gggcctatac acccccgctc      900

cttatgctat aggtgatggt atagcttagc ctataggtgt gggttattga ccattattga      960

ccactcccct attggtgacg atactttcca ttactaatcc ataacatggc tctttgccac     1020

aactatctct attggctata tgccaatact ctgtccttca gagactgaca cggactctgt     1080

atttttacag gatggggtcc catttattat ttacaaattc acatatacaa caacgccgtc     1140

ccccgtgccc gcagttttta ttaaacatag cgtgggatct ccacgcgaat ctcgggtacg     1200

tgttccggac atgggctctt ctccggtagc ggcggagctt ccacatccga gccctggtcc     1260

catgcctcca gcggctcatg gtcgctcggc agctccttgc tcctaacagt ggaggccaga     1320

cttaggcaca gcacaatgcc caccaccacc agtgtgccgc acaaggccgt ggcggtaggg     1380

tatgtgtctg aaaatgagct cggagattgg gctcgcaccg tgacgcagat ggaagactta     1440

aggcagcggc agaagaagat gcaggcagct gagttgttgt attctgataa gagtcagagg     1500

taactcccgt tgcggtgctg ttaacggtgg agggcagtgt agtctgagca gtactcgttg     1560

ctgccgcgcg cgccaccaga cataatagct gacagactaa cagactgttc ctttccatgg     1620

gtcttttctg cagtcaccgt ccaagcttat ggaaaagatc gtgctgctgc tggctatcgt     1680

gagcctggtg aagagcgacc agatttgcat cggctaccac gccaacaaca gcaccgagca     1740

ggtggacacc atcatggaaa agaacgtcac cgtgacccac gcccaggaca tcctggaaaa     1800

gacccacaac ggcaagctgt gcgacctgga cggcgtgaag cccctgatcc tgagggactg     1860

cagcgtggcc ggctggctgc tgggcaaccc catgtgcgac gagttcatca acgtgcccga     1920

gtggagctac atcgtggaga aggccaaccc cgccaacgac ctgtgctacc ccggcaactt     1980

caacgactac gaggaactga agcacctgct gtccaggatc aaccacttcg agaagatcca     2040

gatcatcccc aagagcagct ggtccgacca cgaggccagc agcggcgtga gcagcgcctg     2100

cccataccag ggcagcccca gcttcttcag aaacgtggtg tggctgatca agaagaacaa     2160

cacctacccc accatcaaga ggtcctacaa caacaccaac caggaagatc tgctggtcct     2220

gtggggcatc caccacccta atgacgccgc cgaacagacc aggctgtacc agaaccccac     2280

cacctacatc agcgtgggca caagcaccct gaaccagagg ctggtgccca agatcgccac     2340

caggtccaag gtgaacggac agtccggcag gatggaattc ttctggacca tcctgaagcc     2400

taacgacgcc atcaacttcg agagcaacgg caactttatc gcccccgagt acgcctacaa     2460

gatcgtgaag aagggcgaca gcgccatcat gaagagcgag ctggaatacg gcaactgcaa     2520

caccaagtgc cagaccccca tcggcgccat caacagcagc atgcccttcc acaacatcca     2580

ccccctgacc atcggcgagt gccccaagta cgtgaagagc aacaggctgg tgctggccac     2640

cggcctgagg aacagccccc agagagagag cagaagaaag aagaggggcc tgttcggcgc     2700

tatcgccggc ttcatcgagg gcggctggca gggcatggtg gacgggtggt acggctacca     2760

ccactctaac gagcagggca gcggctacgc cgccgacaaa gagagcaccc agaaggccat     2820

cgacggcgtc accaacaagg tgaacagcat catcgacaag atgaacaccc agttcgaggc     2880

cgtgggcaga gagttcaaca acctggaaag gcggatcgag aacctgaaca agaaaatgga     2940

agatggcttc ctggacgtgt ggacctacaa cgccgagctg ctggtgctga tggaaaacga     3000

gaggaccctg gacttccacg acagcaacgt gaagaacctg tacgacaaag tgcggctgca     3060

gctgagggac aacgccaaag agctgggcaa cggctgcttc gagttctacc acaagtgcga     3120

caacgagtgc atggaaagcg tgaggaacgg cacctacgac tacccccagt acagcgagga     3180

agccaggctg aagagggaag agatcagcgg agtgaagctg gaaagcatcg gcacctacca     3240

gatcctgagc atctacagca ccgtcgccag cagcctggcc ctggctatca tggtggccgg     3300

actgagcctg tggatgtgca gcaacggcag cctgcagtgc aggatctgca tcggatcctc     3360

gcaatcccta gggctgtgcc ttctagttgc cagccaaact gttgtttgcc cctcccccgt     3420

gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat     3480

tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag     3540

caagggggag gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatgtt     3600

cagaacgctc ggttgccgcc gggcgttttt tatctagagt cgacaaattc agaagaactc     3660

gtcaagaagg cgatagaagg cgatgcgctg cgaatcggga gcggcgatac cgtaaagcac     3720

gaggaagcgg tcagcccatt cgccgccaag ctcttcagca atatcacggg tagccaacgc     3780

tatgtcctga tagcggtccg ccacacccag ccggccacag tcgatgaatc cagaaaagcg     3840

gccattttcc accatgatat tcggcaagca ggcatcgcca tgggtcacga cgagatcctc     3900

gccgtcgggc atgctcgcct tgagcctggc gaacagttcg gctggcgcga gcccctgatg     3960

ctcttcgtcc agatcatcct gatcgacaag accggcttcc atccgagtac gtgctcgctc     4020

gatgcgatgt ttcgcttggt ggtcgaatgg gcaggtagcc ggatcaagcg tatgcagccg     4080

ccgcattgca tcagccatga tggatacttt ctcggcagga gcaaggtgag atgacaggag     4140

atcctgcccc ggcacttcgc ccaatagcag ccagtccctt cccgcttcag tgacaacgtc     4200

gagcacagct gcgcaaggaa cgcccgtcgt ggccagccac gatagccgcg ctgcctcgtc     4260

ttgcagttca ttcagggcac cggacaggtc ggtcttgaca aaaagaaccg ggcgcccctg     4320

cgctgacagc cggaacacgg cggcatcaga gcagccgatt gtctgttgtg cccagtcata     4380

gccgaatagc ctctccaccc aagcggccgg agaacctgcg tgcaatccat cttgttcaat     4440

catgcgaaac gatcctcatc ctgtctcttg atcagatctt gatcccctgc gccatcagat     4500

ccttggcggc gagaaagcca tccagtttac tttgcagggc ttcccaacct taccagaggg     4560

cgccccagct ggcaattccg gttcgcttgc tgtccataaa accgcccagt ctagctatcg     4620

ccatgtaagc ccactgcaag ctacctgctt tctctttgcg cttgcgtttt cccttgtcca     4680

gatagcccag tagctgacat tcatccgggg tcagcaccgt ttctgcggac tggctttcta     4740

cgtgaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg     4800

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga     4860

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt     4920

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag     4980

agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa     5040

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag     5100

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca     5160

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac     5220

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa     5280

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc     5340

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg     5400

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc     5460

ctttttacgg ttcctgggct tttgctggcc ttttgctcac atgttgtcga c              5511


<210>  8
<211>  5769
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      420

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      480

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      540

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      600

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      660

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      720

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      780

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      840

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      900

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      960

tagaagacac cgggaccgat ccagcctcca tcggctcgca tctctccttc acgcgcccgc     1020

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     1080

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     1140

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     1200

accctgcttg ctcaactcta gttaacggtg gagggcagtg tagtctgagc agtactcgtt     1260

gctgccgcgc gcgccaccag acataatagc tgacagacta acagactgtt cctttccatg     1320

ggtcttttct gcagtcaccg tcgtcgacac gatccgatat cgccgccacc atgaatccta     1380

ataagaagat catcacaatc ggaagcatct gcatggtgac aggaatggtg agcctgatgc     1440

tgcagatcgg aaatctgatc agcatctggg tgagccacag catccacaca ggaaatcagc     1500

acaaggccga gcctatcagc aatacaaatt ttctgacaga gaaggccgtg gccagcgtga     1560

agctggccgg aaatagcagc ctgtgcccta tcaatggatg ggccgtgtac agcaaggata     1620

atagcatcag aatcggaagc aagggagatg tgtttgtgat cagagagcct tttatcagct     1680

gcagccacct ggagtgcaga acattttttc tgacacaggg agccctgctg aatgataagc     1740

acagcaatgg aacagtgaag gatagaagcc ctcacagaac actgatgagc tgccctgtgg     1800

gagaggcccc tagcccttac aatagcagat ttgagagcgt ggcctggagc gccagcgcct     1860

gccacgatgg aacaagctgg ctgacaatcg gaatcagcgg acctgataat ggagccgtgg     1920

ccgtgctgaa gtacaatgga atcatcacag atacaatcaa gagctggaga aataatatcc     1980

tgagaacaca ggagagcgag tgcgcctgcg tgaatggaag ctgctttaca gtgatgacag     2040

atggacctag caatggacag gccagccaca agatctttaa gatggagaag ggaaaggtgg     2100

tgaagagcgt ggagctggat gcccctaatt accactacga ggagtgcagc tgctaccctg     2160

atgccggaga gatcacatgc gtgtgcagag ataattggca cggaagcaat agaccttggg     2220

tgagctttaa tcagaatctg gagtaccaga tcggatacat ctgcagcgga gtgtttggag     2280

ataatcctag acctaatgat ggaacaggaa gctgcggacc tgtgagcagc aatggagcct     2340

acggagtgaa gggatttagc tttaagtacg gaaatggagt gtggatcgga agaacaaaga     2400

gcacaaatag cagaagcgga tttgagatga tctgggaccc taatggatgg acagagacag     2460

atagcagctt tagcgtgaag caggatatcg tggccatcac agattggagc ggatacagcg     2520

gaagctttgt gcagcaccct gagctgacag gactggattg catcagacct tgcttttggg     2580

tggagctgat cagaggaaga cctaaggaga gcacaatctg gacaagcgga agcagcatca     2640

gcttttgcgg agtgaatagc gatacagtgg gatggagctg gcctgatgga gccgagctgc     2700

cttttacaat cgataagtga gcggccgctc tagaccaggc cctggatcca gatctgctgt     2760

gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga     2820

aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag     2880

taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga     2940

agacaatagc aggcatgctg gggatgcggt gggctctatg ggtacccagg tgctgaagaa     3000

ttgacccggt tcctcctggg ccagaaagaa gcaggcacat ccccttctct gtgacacacc     3060

ctgtccacgc ccctggttct tagttccagc cccactcata ggacactcat agctcaggag     3120

ggctccgcct tcaatcccac ccgctaaagt acttggagcg gtctctccct ccctcatcag     3180

cccaccaaac caaacctagc ctccaagagt gggaagaaat taaagcaaga taggctatta     3240

agtgcagagg gagagaaaat gcctccaaca tgtgaggaag taatgagaga aatcatagaa     3300

ttttaaggcc atgatttaag gccatcatgg ccttaatctt ccgcttcctc gctcactgac     3360

tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata     3420

cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa     3480

aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct     3540

gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa     3600

agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg     3660

cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca     3720

cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa     3780

ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg     3840

gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg     3900

tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga     3960

acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc     4020

tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag     4080

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac     4140

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc     4200

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag     4260

taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt     4320

ctatttcgtt catccatagt tgcctgactc gggggggggg ggcgctgagg tctgcctcgt     4380

gaagaaggtg ttgctgactc ataccaggcc tgaatcgccc catcatccag ccagaaagtg     4440

agggagccac ggttgatgag agctttgttg taggtggacc agttggtgat tttgaacttt     4500

tgctttgcca cggaacggtc tgcgttgtcg ggaagatgcg tgatctgatc cttcaactca     4560

gcaaaagttc gatttattca acaaagccgc cgtcccgtca agtcagcgta atgctctgcc     4620

agtgttacaa ccaattaacc aattctgatt agaaaaactc atcgagcatc aaatgaaact     4680

gcaatttatt catatcagga ttatcaatac catatttttg aaaaagccgt ttctgtaatg     4740

aaggagaaaa ctcaccgagg cagttccata ggatggcaag atcctggtat cggtctgcga     4800

ttccgactcg tccaacatca atacaaccta ttaatttccc ctcgtcaaaa ataaggttat     4860

caagtgagaa atcaccatga gtgacgactg aatccggtga gaatggcaaa agcttatgca     4920

tttctttcca gacttgttca acaggccagc cattacgctc gtcatcaaaa tcactcgcat     4980

caaccaaacc gttattcatt cgtgattgcg cctgagcgag acgaaatacg cgatcgctgt     5040

taaaaggaca attacaaaca ggaatcgaat gcaaccggcg caggaacact gccagcgcat     5100

caacaatatt ttcacctgaa tcaggatatt cttctaatac ctggaatgct gttttcccgg     5160

ggatcgcagt ggtgagtaac catgcatcat caggagtacg gataaaatgc ttgatggtcg     5220

gaagaggcat aaattccgtc agccagttta gtctgaccat ctcatctgta acatcattgg     5280

caacgctacc tttgccatgt ttcagaaaca actctggcgc atcgggcttc ccatacaatc     5340

gatagattgt cgcacctgat tgcccgacat tatcgcgagc ccatttatac ccatataaat     5400

cagcatccat gttggaattt aatcgcggcc tcgagcaaga cgtttcccgt tgaatatggc     5460

tcataacacc ccttgtatta ctgtttatgt aagcagacag ttttattgtt catgatgata     5520

tatttttatc ttgtgcaatg taacatcaga gattttgaga cacaacgtgg ctttcccccc     5580

ccccccatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat     5640

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     5700

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     5760

cctttcgtc                                                             5769


<210>  9
<211>  4598
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial construct

<400>  9
cgacaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta       60

tattggctca tgtccaatat gaccgccatg ttgacattga ttattgacta gttattaata      120

gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact      180

tacggtaaat ggcccgcctc gtgaccgccc aacgaccccc gcccattgac gtcaataatg      240

acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat      300

ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag tccgccccta      360

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttacggg      420

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt      480

tttggcagta caccaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc      540

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat      600

gtcgtaataa ccccgccccg ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct      660

atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt      720

ttgacctcca tagaagacac cgggaccgat ccagcctccg cggccgggaa cggtgcattg      780

gaacgcggat tccccgtgcc aagagtgacg taagtaccgc ctatagactc tataggcaca      840

cccctttggc tcttatgcat gctatactgt ttttggcttg gggcctatac acccccgctc      900

cttatgctat aggtgatggt atagcttagc ctataggtgt gggttattga ccattattga      960

ccactcccct attggtgacg atactttcca ttactaatcc ataacatggc tctttgccac     1020

aactatctct attggctata tgccaatact ctgtccttca gagactgaca cggactctgt     1080

atttttacag gatggggtcc catttattat ttacaaattc acatatacaa caacgccgtc     1140

ccccgtgccc gcagttttta ttaaacatag cgtgggatct ccacgcgaat ctcgggtacg     1200

tgttccggac atgggctctt ctccggtagc ggcggagctt ccacatccga gccctggtcc     1260

catgcctcca gcggctcatg gtcgctcggc agctccttgc tcctaacagt ggaggccaga     1320

cttaggcaca gcacaatgcc caccaccacc agtgtgccgc acaaggccgt ggcggtaggg     1380

tatgtgtctg aaaatgagct cggagattgg gctcgcaccg tgacgcagat ggaagactta     1440

aggcagcggc agaagaagat gcaggcagct gagttgttgt attctgataa gagtcagagg     1500

taactcccgt tgcggtgctg ttaacggtgg agggcagtgt agtctgagca gtactcgttg     1560

ctgccgcgcg cgccaccaga cataatagct gacagactaa cagactgttc ctttccatgg     1620

gtcttttctg cagtcaccgt ccaagcttag atctgccacc atgagcctgc tgaccgaggt     1680

ggagacatac gtgctgtcca tcatccccag cggccctctg aaggccgaga tcgcccagag     1740

actggaagat gtgttcgccg gcaagaacac cgacctggaa gtgctgatgg aatggctgaa     1800

aaccagaccc atcctgagcc ctctgaccaa gggcatcctg ggcttcgtgt tcaccctgac     1860

cgtgcccagc gagagaggcc tgcagaggcg gagattcgtg cagaacgccc tgaacggcaa     1920

cggcgacccc aacaacatgg acaaggccgt gaagctgtac agaaagctga agcgggagat     1980

caccttccac ggcgccaaag agatcagcct gagctacagc gctggcgccc tggccagctg     2040

catgggcctg atctacaaca gaatgggcgc cgtgaccacc gaggtggcct tcggcctggt     2100

ctgcgccacc tgcgagcaga tcgccgacag ccagcacaga tcccacagac agatggtcac     2160

caccaccaac cccctgatca gacacgagaa cagaatggtg ctggcctcta ccaccgccaa     2220

ggccatggaa cagatggccg gcagcagcga gcaggccgcc gaggctatgg aagtcgcctc     2280

tcaggctagg cagatggtcc aggccatgag aaccatcggc acccacccca gcagctctgc     2340

tggcctgaag aacgacctgc tggaaaacct gcaggcctac cagaaaagaa tgggcgtcca     2400

gatgcagaga ttcaagtgat gagatatccc tcagagaggg gatcctcgca atccctaggg     2460

ctgtgccttc tagttgccag ccaaactgtt gtttgcccct cccccgtgcc ttccttgacc     2520

ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt     2580

ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat     2640

tgggaagaca atagcaggca tgctggggat gcggtgggct ctatgttcag aacgctcggt     2700

tgccgccggg cgttttttat ctagagtcga caaattcaga agaactcgtc aagaaggcga     2760

tagaaggcga tgcgctgcga atcgggagcg gcgataccgt aaagcacgag gaagcggtca     2820

gcccattcgc cgccaagctc ttcagcaata tcacgggtag ccaacgctat gtcctgatag     2880

cggtccgcca cacccagccg gccacagtcg atgaatccag aaaagcggcc attttccacc     2940

atgatattcg gcaagcaggc atcgccatgg gtcacgacga gatcctcgcc gtcgggcatg     3000

ctcgccttga gcctggcgaa cagttcggct ggcgcgagcc cctgatgctc ttcgtccaga     3060

tcatcctgat cgacaagacc ggcttccatc cgagtacgtg ctcgctcgat gcgatgtttc     3120

gcttggtggt cgaatgggca ggtagccgga tcaagcgtat gcagccgccg cattgcatca     3180

gccatgatgg atactttctc ggcaggagca aggtgagatg acaggagatc ctgccccggc     3240

acttcgccca atagcagcca gtcccttccc gcttcagtga caacgtcgag cacagctgcg     3300

caaggaacgc ccgtcgtggc cagccacgat agccgcgctg cctcgtcttg cagttcattc     3360

agggcaccgg acaggtcggt cttgacaaaa agaaccgggc gcccctgcgc tgacagccgg     3420

aacacggcgg catcagagca gccgattgtc tgttgtgccc agtcatagcc gaatagcctc     3480

tccacccaag cggccggaga acctgcgtgc aatccatctt gttcaatcat gcgaaacgat     3540

cctcatcctg tctcttgatc agatcttgat cccctgcgcc atcagatcct tggcggcgag     3600

aaagccatcc agtttacttt gcagggcttc ccaaccttac cagagggcgc cccagctggc     3660

aattccggtt cgcttgctgt ccataaaacc gcccagtcta gctatcgcca tgtaagccca     3720

ctgcaagcta cctgctttct ctttgcgctt gcgttttccc ttgtccagat agcccagtag     3780

ctgacattca tccggggtca gcaccgtttc tgcggactgg ctttctacgt gaaaaggatc     3840

taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc     3900

cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg     3960

cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg     4020

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca     4080

aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg     4140

cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg     4200

tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga     4260

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac     4320

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat     4380

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc     4440

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga     4500

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc     4560

ctgggctttt gctggccttt tgctcacatg ttgtcgac                             4598


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  10

Ile Tyr Ser Thr Val Ala Ser Ser Leu 
1               5                   


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  11

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


