                         SEQUENCE LISTING

<110>  University of South Florida
       University of Florida Research Foundation, Inc.
       The United States Government as represented by the 
       Department of Veterans Affairs
 
<120>  USE OF PKC-IOTA INHIBITORS FOR THE TREATMENT OF BREAST CANCER

<130>  USF.305XC1PCT

<150>  61/384,023
<151>  2010-09-17

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser His Thr Val Ala Gly Gly Gly Ser Gly Asp His Ser His Gln 
1               5                   10                  15      


Val Arg Val Lys Ala Tyr Tyr Arg Gly Asp Ile Met Ile Thr His Phe 
            20                  25                  30          


Glu Pro Ser Ile Ser Phe Glu Gly Leu Cys Asn Glu Val Arg Asp Met 
        35                  40                  45              


Cys Ser Phe Asp Asn Glu Gln Leu Phe Thr Met Lys Trp Ile Asp Glu 
    50                  55                  60                  


Glu Gly Asp Pro Cys Thr Val Ser Ser Gln Leu Glu Leu Glu Glu Ala 
65                  70                  75                  80  


Phe Arg Leu Tyr Glu Leu Asn Lys Asp Ser Glu Leu Leu Ile His Val 
                85                  90                  95      


Phe Pro Cys Val Pro Glu Arg Pro Gly Met Pro Cys Pro Gly Glu Asp 
            100                 105                 110         


Lys Ser Ile Tyr Arg Arg Gly Ala Arg Arg Trp Arg Lys Leu Tyr Cys 
        115                 120                 125             


Ala Asn Gly His Thr Phe Gln Ala Lys Arg Phe Asn Arg Arg Ala His 
    130                 135                 140                 


Cys Ala Ile Cys Thr Asp Arg Ile Trp Gly Leu Gly Arg Gln Gly Tyr 
145                 150                 155                 160 


Lys Cys Ile Asn Cys Lys Leu Leu Val His Lys Lys Cys His Lys Leu 
                165                 170                 175     


Val Thr Ile Glu Cys Gly Arg His Ser Leu Pro Gln Glu Pro Val Met 
            180                 185                 190         


Pro Met Asp Gln Ser Ser Met His Ser Asp His Ala Gln Thr Val Ile 
        195                 200                 205             


Pro Tyr Asn Pro Ser Ser His Glu Ser Leu Asp Gln Val Gly Glu Glu 
    210                 215                 220                 


Lys Glu Ala Met Asn Thr Arg Glu Ser Gly Lys Ala Ser Ser Ser Leu 
225                 230                 235                 240 


Gly Leu Gln Asp Phe Asp Leu Leu Arg Val Ile Gly Arg Gly Ser Tyr 
                245                 250                 255     


Ala Lys Val Leu Leu Val Arg Leu Lys Lys Thr Asp Arg Ile Tyr Ala 
            260                 265                 270         


Met Lys Val Val Lys Lys Glu Leu Val Asn Asp Asp Glu Asp Ile Asp 
        275                 280                 285             


Trp Val Gln Thr Glu Lys His Val Phe Glu Gln Ala Ser Asn His Pro 
    290                 295                 300                 


Phe Leu Val Gly Leu His Ser Cys Phe Gln Thr Glu Ser Arg Leu Phe 
305                 310                 315                 320 


Phe Val Ile Glu Tyr Val Asn Gly Gly Asp Leu Met Phe His Met Gln 
                325                 330                 335     


Arg Gln Arg Lys Leu Pro Glu Glu His Ala Arg Phe Tyr Ser Ala Glu 
            340                 345                 350         


Ile Ser Leu Ala Leu Asn Tyr Leu His Glu Arg Gly Ile Ile Tyr Arg 
        355                 360                 365             


Asp Leu Lys Leu Asp Asn Val Leu Leu Asp Ser Glu Gly His Ile Lys 
    370                 375                 380                 


Leu Thr Asp Tyr Gly Met Cys Lys Glu Gly Leu Arg Pro Gly Asp Thr 
385                 390                 395                 400 


Thr Ser Thr Phe Cys Gly Thr Pro Asn Tyr Ile Ala Pro Glu Ile Leu 
                405                 410                 415     


Arg Gly Glu Asp Tyr Gly Phe Ser Val Asp Trp Trp Ala Leu Gly Val 
            420                 425                 430         


Leu Met Phe Glu Met Met Ala Gly Arg Ser Pro Phe Asp Ile Val Gly 
        435                 440                 445             


Ser Ser Asp Asn Pro Asp Gln Asn Thr Glu Asp Tyr Leu Phe Gln Val 
    450                 455                 460                 


Ile Leu Glu Lys Gln Ile Arg Ile Pro Arg Ser Leu Ser Val Lys Ala 
465                 470                 475                 480 


Ala Ser Val Leu Lys Ser Phe Leu Asn Lys Asp Pro Lys Glu Arg Leu 
                485                 490                 495     


Gly Cys His Pro Gln Thr Gly Phe Ala Asp Ile Gln Gly His Pro Phe 
            500                 505                 510         


Phe Arg Asn Val Asp Trp Asp Met Met Glu Gln Lys Gln Val Val Pro 
        515                 520                 525             


Pro Phe Lys Pro Asn Ile Ser Gly Glu Phe Gly Leu Asp Asn Phe Asp 
    530                 535                 540                 


Ser Gln Phe Thr Asn Glu Pro Val Gln Leu Thr Pro Asp Asp Asp Asp 
545                 550                 555                 560 


Ile Val Arg Lys Ile Asp Gln Ser Glu Phe Glu Gly Phe Glu Tyr Ile 
                565                 570                 575     


Asn Pro Leu Leu Met Ser Ala Glu Glu Cys Val 
            580                 585         


<210>  2
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  single strand of PKC-iota siRNA

<400>  2
caagccaagc guuucaaca                                                    19


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a single strand of PKC-iota siRNA

<400>  3
uguugaaacg cuuggcuug                                                    19


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a single strand of PKC-iota siRNA

<400>  4
ggaacgauug gguugucau                                                    19


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a single strand of PKC-iota siRNA

<400>  5
augacaaccc aaucguuucc                                                   20


<210>  6
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a single strand of PKC-iota siRNA

<400>  6
cccaauaucu ucucuugua                                                    19


<210>  7
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a single strand of PKC-iota siRNA

<400>  7
uacaagagaa gauauuggg                                                    19


