                         SEQUENCE LISTING

<110>  Merz Pharma GmbH & Co.KGaA
 
<120>  Botulinum neurotoxin polypeptides exhibiting prolonged activity

<130>  MP10045PC

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  3891
<212>  DNA
<213>  Clostridium botulinum

<400>  1
atgccatttg ttaataaaca atttaattat aaagatcctg taaatggtgt tgatattgct       60

tatataaaaa ttccaaatgc aggacaaatg caaccagtaa aagcttttaa aattcataat      120

aaaatatggg ttattccaga aagagataca tttacaaatc ctgaagaagg agatttaaat      180

ccaccaccag aagcaaaaca agttccagtt tcatattatg attcaacata tttaagtaca      240

gataatgaaa aagataatta tttaaaggga gttacaaaat tatttgagag aatttattca      300

actgatcttg gaagaatgtt gttaacatca atagtaaggg gaataccatt ttggggtgga      360

agtacaatag atacagaatt aaaagttatt gatactaatt gtattaatgt gatacaacca      420

gatggtagtt atagatcaga agaacttaat ctagtaataa taggaccctc agctgatatt      480

atacagtttg aatgtaaaag ctttggacat gaagttttga atcttacgcg aaatggttat      540

ggctctactc aatacattag atttagccca gattttacat ttggttttga ggagtcactt      600

gaagttgata caaatcctct tttaggtgca ggcaaatttg ctacagatcc agcagtaaca      660

ttagcacatg aacttataca tgctggacat agattatatg gaatagcaat taatccaaat      720

agggttttta aagtaaatac taatgcctat tatgaaatga gtgggttaga agtaagcttt      780

gaggaactta gaacatttgg gggacatgat gcaaagttta tagatagttt acaggaaaac      840

gaatttcgtc tatattatta taataagttt aaagatatag caagtacact taataaagct      900

aaatcaatag taggtactac tgcttcatta cagtatatga aaaatgtttt taaagagaaa      960

tatctcctat ctgaagatac atctggaaaa ttttcggtag ataaattaaa atttgataag     1020

ttatacaaaa tgttaacaga gatttacaca gaggataatt ttgttaagtt ttttaaagta     1080

cttaacagaa aaacatattt gaattttgat aaagccgtat ttaagataaa tatagtacct     1140

aaggtaaatt acacaatata tgatggattt aatttaagaa atacaaattt agcagcaaac     1200

tttaatggtc aaaatacaga aattaataat atgaatttta ctaaactaaa aaattttact     1260

ggattgtttg aattttataa gttgctatgt gtaagaggga taataacttc taaaactaaa     1320

tcattagata aaggatacaa taaggcatta aatgatttat gtatcaaagt taataattgg     1380

gacttgtttt ttagtccttc agaagataat tttactaatg atctaaataa aggagaagaa     1440

attacatctg atactaatat agaagcagca gaagaaaata ttagtttaga tttaatacaa     1500

caatattatt taacctttaa ttttgataat gaacctgaaa atatttcaat agaaaatctt     1560

tcaagtgaca ttataggcca attagaactt atgcctaata tagaaagatt tcctaatgga     1620

aaaaagtatg agttagataa atatactatg ttccattatc ttcgtgctca agaatttgaa     1680

catggtaaat ctaggattgc tttaacaaat tctgttaacg aagcattatt aaatcctagt     1740

cgtgtttata catttttttc ttcagactat gtaaagaaag ttaataaagc tacggaggca     1800

gctatgtttt taggctgggt agaacaatta gtatatgatt ttaccgatga aactagcgaa     1860

gtaagtacta cggataaaat tgcggatata actataatta ttccatatat aggacctgct     1920

ttaaatatag gtaatatgtt atataaagat gattttgtag gtgctttaat attttcagga     1980

gctgttattc tgttagaatt tataccagag attgcaatac ctgtattagg tacttttgca     2040

cttgtatcat atattgcgaa taaggttcta accgttcaaa caatagataa tgctttaagt     2100

aaaagaaatg aaaaatggga tgaggtctat aaatatatag taacaaattg gttagcaaag     2160

gttaatacac agattgatct aataagaaaa aaaatgaaag aagctttaga aaatcaagca     2220

gaagcaacaa aggctataat aaactatcag tataatcaat atactgagga agagaaaaat     2280

aatattaatt ttaatattga tgatttaagt tcgaaactta atgagtctat aaataaagct     2340

atgattaata taaataaatt tttgaatcaa tgctctgttt catatttaat gaattctatg     2400

atcccttatg gtgttaaacg gttagaagat tttgatgcta gtcttaaaga tgcattatta     2460

aagtatatat atgataatag aggaacttta attggtcaag tagatagatt aaaagataaa     2520

gttaataata cacttagtac agatatacct tttcagcttt ccaaatacgt agataatcaa     2580

agattattat ctacatttac tgaatatatt aagaatatta ttaatacttc tatattgaat     2640

ttaagatatg aaagtaatca tttaatagac ttatctaggt atgcatcaaa aataaatatt     2700

ggtagtaaag taaattttga tccaatagat aaaaatcaaa ttcaattatt taatttagaa     2760

agtagtaaaa ttgaggtaat tttaaaaaat gctattgtat ataatagtat gtatgaaaat     2820

tttagtacta gcttttggat aagaattcct aagtatttta acagtataag tctaaataat     2880

gaatatacaa taataaattg tatggaaaat aattcaggat ggaaagtatc acttaattat     2940

ggtgaaataa tctggacttt acaggatact caggaaataa aacaaagagt agtttttaaa     3000

tacagtcaaa tgattaatat atcagattat ataaacagat ggatttttgt aactatcact     3060

aataatagat taaataactc taaaatttat ataaatggaa gattaataga tcaaaaacca     3120

atttcaaatt taggtaatat tcatgctagt aataatataa tgtttaaatt agatggttgt     3180

agagatacac atagatatat ttggataaaa tattttaatc tttttgataa ggaattaaat     3240

gaaaaagaaa tcaaagattt atatgataat caatcaaatt caggtatttt aaaagacttt     3300

tggggtgatt atttacaata tgataaacca tactatatgt taaatttata tgatccaaat     3360

aaatatgtcg atgtaaataa tgtaggtatt agaggttata tgtatcttaa agggcctaga     3420

ggtagcgtaa tgactacaaa catttattta aattcaagtt tgtatagggg gacaaaattt     3480

attataaaaa aatatgcttc tggaaataaa gataatattg ttagaaataa tgatcgtgta     3540

tatattaatg tagtagttaa aaataaagaa tataggttag ctactaatgc atcacaggca     3600

ggcgtagaaa aaatactaag tgcattagaa atacctgatg taggaaatct aagtcaagta     3660

gtagtaatga agtcaaaaaa tgatcaagga ataacaaata aatgcaaaat gaatttacaa     3720

gataataatg ggaatgatat aggctttata ggatttcatc agtttaataa tatagctaaa     3780

ctagtagcaa gtaattggta taatagacaa atagaaagat ctagtaggac tttgggttgc     3840

tcatgggaat ttattcctgt agatgatgga tggggagaaa ggccactgta a              3891


<210>  2
<211>  3661
<212>  PRT
<213>  Clostridium botulinum

<400>  2

Met Glu Thr Pro Arg Pro His Glu Val Ala Leu Ala Ser Asn Leu Tyr 
1               5                   10                  15      


Ser Gly Leu Asn Pro His Glu Ala Ser Asn Thr Tyr Arg Leu Tyr Ser 
            20                  25                  30          


Ala Ser Pro Pro Arg Val Ala Leu Ala Ser Asn Gly Leu Tyr Val Ala 
        35                  40                  45              


Leu Ala Ser Pro Ile Leu Glu Ala Leu Ala Thr Tyr Arg Ile Leu Glu 
    50                  55                  60                  


Leu Tyr Ser Ile Leu Glu Pro Arg Ala Ser Asn Ala Leu Ala Gly Leu 
65                  70                  75                  80  


Tyr Gly Leu Asn Met Glu Thr Gly Leu Asn Pro Arg Val Ala Leu Leu 
                85                  90                  95      


Tyr Ser Ala Leu Ala Pro His Glu Leu Tyr Ser Ile Leu Glu His Ile 
            100                 105                 110         


Ser Ala Ser Asn Leu Tyr Ser Ile Leu Glu Thr Arg Pro Val Ala Leu 
        115                 120                 125             


Ile Leu Glu Pro Arg Gly Leu Ala Arg Gly Ala Ser Pro Thr His Arg 
    130                 135                 140                 


Pro His Glu Thr His Arg Ala Ser Asn Pro Arg Gly Leu Gly Leu Gly 
145                 150                 155                 160 


Leu Tyr Ala Ser Pro Leu Glu Ala Ser Asn Pro Arg Pro Arg Pro Arg 
                165                 170                 175     


Gly Leu Ala Leu Ala Leu Tyr Ser Gly Leu Asn Val Ala Leu Pro Arg 
            180                 185                 190         


Val Ala Leu Ser Glu Arg Thr Tyr Arg Thr Tyr Arg Ala Ser Pro Ser 
        195                 200                 205             


Glu Arg Thr His Arg Thr Tyr Arg Leu Glu Ser Glu Arg Thr His Arg 
    210                 215                 220                 


Ala Ser Pro Ala Ser Asn Gly Leu Leu Tyr Ser Ala Ser Pro Ala Ser 
225                 230                 235                 240 


Asn Thr Tyr Arg Leu Glu Leu Tyr Ser Gly Leu Tyr Val Ala Leu Thr 
                245                 250                 255     


His Arg Leu Tyr Ser Leu Glu Pro His Glu Gly Leu Ala Arg Gly Ile 
            260                 265                 270         


Leu Glu Thr Tyr Arg Ser Glu Arg Thr His Arg Ala Ser Pro Leu Glu 
        275                 280                 285             


Gly Leu Tyr Ala Arg Gly Met Glu Thr Leu Glu Leu Glu Thr His Arg 
    290                 295                 300                 


Ser Glu Arg Ile Leu Glu Val Ala Leu Ala Arg Gly Gly Leu Tyr Ile 
305                 310                 315                 320 


Leu Glu Pro Arg Pro His Glu Thr Arg Pro Gly Leu Tyr Gly Leu Tyr 
                325                 330                 335     


Ser Glu Arg Thr His Arg Ile Leu Glu Ala Ser Pro Thr His Arg Gly 
            340                 345                 350         


Leu Leu Glu Leu Tyr Ser Val Ala Leu Ile Leu Glu Ala Ser Pro Thr 
        355                 360                 365             


His Arg Ala Ser Asn Cys Tyr Ser Ile Leu Glu Ala Ser Asn Val Ala 
    370                 375                 380                 


Leu Ile Leu Glu Gly Leu Asn Pro Arg Ala Ser Pro Gly Leu Tyr Ser 
385                 390                 395                 400 


Glu Arg Thr Tyr Arg Ala Arg Gly Ser Glu Arg Gly Leu Gly Leu Leu 
                405                 410                 415     


Glu Ala Ser Asn Leu Glu Val Ala Leu Ile Leu Glu Ile Leu Glu Gly 
            420                 425                 430         


Leu Tyr Pro Arg Ser Glu Arg Ala Leu Ala Ala Ser Pro Ile Leu Glu 
        435                 440                 445             


Ile Leu Glu Gly Leu Asn Pro His Glu Gly Leu Cys Tyr Ser Leu Tyr 
    450                 455                 460                 


Ser Ser Glu Arg Pro His Glu Gly Leu Tyr His Ile Ser Gly Leu Val 
465                 470                 475                 480 


Ala Leu Leu Glu Ala Ser Asn Leu Glu Thr His Arg Ala Arg Gly Ala 
                485                 490                 495     


Ser Asn Gly Leu Tyr Thr Tyr Arg Gly Leu Tyr Ser Glu Arg Thr His 
            500                 505                 510         


Arg Gly Leu Asn Thr Tyr Arg Ile Leu Glu Ala Arg Gly Pro His Glu 
        515                 520                 525             


Ser Glu Arg Pro Arg Ala Ser Pro Pro His Glu Thr His Arg Pro His 
    530                 535                 540                 


Glu Gly Leu Tyr Pro His Glu Gly Leu Gly Leu Ser Glu Arg Leu Glu 
545                 550                 555                 560 


Gly Leu Val Ala Leu Ala Ser Pro Thr His Arg Ala Ser Asn Pro Arg 
                565                 570                 575     


Leu Glu Leu Glu Gly Leu Tyr Ala Leu Ala Gly Leu Tyr Leu Tyr Ser 
            580                 585                 590         


Pro His Glu Ala Leu Ala Thr His Arg Ala Ser Pro Pro Arg Ala Leu 
        595                 600                 605             


Ala Val Ala Leu Thr His Arg Leu Glu Ala Leu Ala His Ile Ser Gly 
    610                 615                 620                 


Leu Leu Glu Ile Leu Glu His Ile Ser Ala Leu Ala Gly Leu Tyr His 
625                 630                 635                 640 


Ile Ser Ala Arg Gly Leu Glu Thr Tyr Arg Gly Leu Tyr Ile Leu Glu 
                645                 650                 655     


Ala Leu Ala Ile Leu Glu Ala Ser Asn Pro Arg Ala Ser Asn Ala Arg 
            660                 665                 670         


Gly Val Ala Leu Pro His Glu Leu Tyr Ser Val Ala Leu Ala Ser Asn 
        675                 680                 685             


Thr His Arg Ala Ser Asn Ala Leu Ala Thr Tyr Arg Thr Tyr Arg Gly 
    690                 695                 700                 


Leu Met Glu Thr Ser Glu Arg Gly Leu Tyr Leu Glu Gly Leu Val Ala 
705                 710                 715                 720 


Leu Ser Glu Arg Pro His Glu Gly Leu Gly Leu Leu Glu Ala Arg Gly 
                725                 730                 735     


Thr His Arg Pro His Glu Gly Leu Tyr Gly Leu Tyr His Ile Ser Ala 
            740                 745                 750         


Ser Pro Ala Leu Ala Leu Tyr Ser Pro His Glu Ile Leu Glu Ala Ser 
        755                 760                 765             


Pro Ser Glu Arg Leu Glu Gly Leu Asn Gly Leu Ala Ser Asn Gly Leu 
    770                 775                 780                 


Pro His Glu Ala Arg Gly Leu Glu Thr Tyr Arg Thr Tyr Arg Thr Tyr 
785                 790                 795                 800 


Arg Ala Ser Asn Leu Tyr Ser Pro His Glu Leu Tyr Ser Ala Ser Pro 
                805                 810                 815     


Ile Leu Glu Ala Leu Ala Ser Glu Arg Thr His Arg Leu Glu Ala Ser 
            820                 825                 830         


Asn Leu Tyr Ser Ala Leu Ala Leu Tyr Ser Ser Glu Arg Ile Leu Glu 
        835                 840                 845             


Val Ala Leu Gly Leu Tyr Thr His Arg Thr His Arg Ala Leu Ala Ser 
    850                 855                 860                 


Glu Arg Leu Glu Gly Leu Asn Thr Tyr Arg Met Glu Thr Leu Tyr Ser 
865                 870                 875                 880 


Ala Ser Asn Val Ala Leu Pro His Glu Leu Tyr Ser Gly Leu Leu Tyr 
                885                 890                 895     


Ser Thr Tyr Arg Leu Glu Leu Glu Ser Glu Arg Gly Leu Ala Ser Pro 
            900                 905                 910         


Thr His Arg Ser Glu Arg Gly Leu Tyr Leu Tyr Ser Pro His Glu Ser 
        915                 920                 925             


Glu Arg Val Ala Leu Ala Ser Pro Leu Tyr Ser Leu Glu Leu Tyr Ser 
    930                 935                 940                 


Pro His Glu Ala Ser Pro Leu Tyr Ser Leu Glu Thr Tyr Arg Leu Tyr 
945                 950                 955                 960 


Ser Met Glu Thr Leu Glu Thr His Arg Gly Leu Ile Leu Glu Thr Tyr 
                965                 970                 975     


Arg Thr His Arg Gly Leu Ala Ser Pro Ala Ser Asn Pro His Glu Val 
            980                 985                 990         


Ala Leu Leu Tyr Ser Pro His Glu  Pro His Glu Leu Tyr  Ser Val Ala 
        995                 1000                 1005             


Leu Leu  Glu Ala Ser Asn Ala  Arg Gly Leu Tyr Ser  Thr His Arg 
    1010                 1015                 1020             


Thr Tyr  Arg Leu Glu Ala Ser  Asn Pro His Glu Ala  Ser Pro Leu 
    1025                 1030                 1035             


Tyr Ser  Ala Leu Ala Val Ala  Leu Pro His Glu Leu  Tyr Ser Ile 
    1040                 1045                 1050             


Leu Glu  Ala Ser Asn Ile Leu  Glu Val Ala Leu Pro  Arg Leu Tyr 
    1055                 1060                 1065             


Ser Val  Ala Leu Ala Ser Asn  Thr Tyr Arg Thr His  Arg Ile Leu 
    1070                 1075                 1080             


Glu Thr  Tyr Arg Ala Ser Pro  Gly Leu Tyr Pro His  Glu Ala Ser 
    1085                 1090                 1095             


Asn Leu  Glu Ala Arg Gly Ala  Ser Asn Thr His Arg  Ala Ser Asn 
    1100                 1105                 1110             


Leu Glu  Ala Leu Ala Ala Leu  Ala Ala Ser Asn Pro  His Glu Ala 
    1115                 1120                 1125             


Ser Asn  Gly Leu Tyr Gly Leu  Asn Ala Ser Asn Thr  His Arg Gly 
    1130                 1135                 1140             


Leu Ile  Leu Glu Ala Ser Asn  Ala Ser Asn Met Glu  Thr Ala Ser 
    1145                 1150                 1155             


Asn Pro  His Glu Thr His Arg  Leu Tyr Ser Leu Glu  Leu Tyr Ser 
    1160                 1165                 1170             


Ala Ser  Asn Pro His Glu Thr  His Arg Gly Leu Tyr  Leu Glu Pro 
    1175                 1180                 1185             


His Glu  Gly Leu Pro His Glu  Thr Tyr Arg Leu Tyr  Ser Leu Glu 
    1190                 1195                 1200             


Leu Glu  Cys Tyr Ser Val Ala  Leu Ala Arg Gly Gly  Leu Tyr Ile 
    1205                 1210                 1215             


Leu Glu  Ile Leu Glu Thr His  Arg Ser Glu Arg Leu  Tyr Ser Thr 
    1220                 1225                 1230             


His Arg  Leu Tyr Ser Ser Glu  Arg Leu Glu Ala Ser  Pro Leu Tyr 
    1235                 1240                 1245             


Ser Gly  Leu Tyr Thr Tyr Arg  Ala Ser Asn Leu Tyr  Ser Ala Leu 
    1250                 1255                 1260             


Ala Leu  Glu Ala Ser Asn Ala  Ser Pro Leu Glu Cys  Tyr Ser Ile 
    1265                 1270                 1275             


Leu Glu  Leu Tyr Ser Val Ala  Leu Ala Ser Asn Ala  Ser Asn Thr 
    1280                 1285                 1290             


Arg Pro  Ala Ser Pro Leu Glu  Pro His Glu Pro His  Glu Ser Glu 
    1295                 1300                 1305             


Arg Pro  Arg Ser Glu Arg Gly  Leu Ala Ser Pro Ala  Ser Asn Pro 
    1310                 1315                 1320             


His Glu  Thr His Arg Ala Ser  Asn Ala Ser Pro Leu  Glu Ala Ser 
    1325                 1330                 1335             


Asn Leu  Tyr Ser Gly Leu Tyr  Gly Leu Gly Leu Ile  Leu Glu Thr 
    1340                 1345                 1350             


His Arg  Ser Glu Arg Ala Ser  Pro Thr His Arg Ala  Ser Asn Ile 
    1355                 1360                 1365             


Leu Glu  Gly Leu Ala Leu Ala  Ala Leu Ala Gly Leu  Gly Leu Ala 
    1370                 1375                 1380             


Ser Asn  Ile Leu Glu Ser Glu  Arg Leu Glu Ala Ser  Pro Leu Glu 
    1385                 1390                 1395             


Ile Leu  Glu Gly Leu Asn Gly  Leu Asn Thr Tyr Arg  Thr Tyr Arg 
    1400                 1405                 1410             


Leu Glu  Thr His Arg Pro His  Glu Ala Ser Asn Pro  His Glu Ala 
    1415                 1420                 1425             


Ser Pro  Ala Ser Asn Gly Leu  Pro Arg Gly Leu Ala  Ser Asn Ile 
    1430                 1435                 1440             


Leu Glu  Ser Glu Arg Ile Leu  Glu Gly Leu Ala Ser  Asn Leu Glu 
    1445                 1450                 1455             


Ser Glu  Arg Ser Glu Arg Ala  Ser Pro Ile Leu Glu  Ile Leu Glu 
    1460                 1465                 1470             


Gly Leu  Tyr Gly Leu Asn Leu  Glu Gly Leu Leu Glu  Met Glu Thr 
    1475                 1480                 1485             


Pro Arg  Ala Ser Asn Ile Leu  Glu Gly Leu Ala Arg  Gly Pro His 
    1490                 1495                 1500             


Glu Pro  Arg Ala Ser Asn Gly  Leu Tyr Leu Tyr Ser  Leu Tyr Ser 
    1505                 1510                 1515             


Thr Tyr  Arg Gly Leu Leu Glu  Ala Ser Pro Leu Tyr  Ser Thr Tyr 
    1520                 1525                 1530             


Arg Thr  His Arg Met Glu Thr  Pro His Glu His Ile  Ser Thr Tyr 
    1535                 1540                 1545             


Arg Leu  Glu Ala Arg Gly Ala  Leu Ala Gly Leu Asn  Gly Leu Pro 
    1550                 1555                 1560             


His Glu  Gly Leu His Ile Ser  Gly Leu Tyr Leu Tyr  Ser Ser Glu 
    1565                 1570                 1575             


Arg Ala  Arg Gly Ile Leu Glu  Ala Leu Ala Leu Glu  Thr His Arg 
    1580                 1585                 1590             


Ala Ser  Asn Ser Glu Arg Val  Ala Leu Ala Ser Asn  Gly Leu Ala 
    1595                 1600                 1605             


Leu Ala  Leu Glu Leu Glu Ala  Ser Asn Pro Arg Ser  Glu Arg Ala 
    1610                 1615                 1620             


Arg Gly  Val Ala Leu Thr Tyr  Arg Thr His Arg Pro  His Glu Pro 
    1625                 1630                 1635             


His Glu  Ser Glu Arg Ser Glu  Arg Ala Ser Pro Thr  Tyr Arg Val 
    1640                 1645                 1650             


Ala Leu  Leu Tyr Ser Leu Tyr  Ser Val Ala Leu Ala  Ser Asn Leu 
    1655                 1660                 1665             


Tyr Ser  Ala Leu Ala Thr His  Arg Gly Leu Ala Leu  Ala Ala Leu 
    1670                 1675                 1680             


Ala Met  Glu Thr Pro His Glu  Leu Glu Gly Leu Tyr  Thr Arg Pro 
    1685                 1690                 1695             


Val Ala  Leu Gly Leu Gly Leu  Asn Leu Glu Val Ala  Leu Thr Tyr 
    1700                 1705                 1710             


Arg Ala  Ser Pro Pro His Glu  Thr His Arg Ala Ser  Pro Gly Leu 
    1715                 1720                 1725             


Thr His  Arg Ser Glu Arg Gly  Leu Val Ala Leu Ser  Glu Arg Thr 
    1730                 1735                 1740             


His Arg  Thr His Arg Ala Ser  Pro Leu Tyr Ser Ile  Leu Glu Ala 
    1745                 1750                 1755             


Leu Ala  Ala Ser Pro Ile Leu  Glu Thr His Arg Ile  Leu Glu Ile 
    1760                 1765                 1770             


Leu Glu  Ile Leu Glu Pro Arg  Thr Tyr Arg Ile Leu  Glu Gly Leu 
    1775                 1780                 1785             


Tyr Pro  Arg Ala Leu Ala Leu  Glu Ala Ser Asn Ile  Leu Glu Gly 
    1790                 1795                 1800             


Leu Tyr  Ala Ser Asn Met Glu  Thr Leu Glu Thr Tyr  Arg Leu Tyr 
    1805                 1810                 1815             


Ser Ala  Ser Pro Ala Ser Pro  Pro His Glu Val Ala  Leu Gly Leu 
    1820                 1825                 1830             


Tyr Ala  Leu Ala Leu Glu Ile  Leu Glu Pro His Glu  Ser Glu Arg 
    1835                 1840                 1845             


Gly Leu  Tyr Ala Leu Ala Val  Ala Leu Ile Leu Glu  Leu Glu Leu 
    1850                 1855                 1860             


Glu Gly  Leu Pro His Glu Ile  Leu Glu Pro Arg Gly  Leu Ile Leu 
    1865                 1870                 1875             


Glu Ala  Leu Ala Ile Leu Glu  Pro Arg Val Ala Leu  Leu Glu Gly 
    1880                 1885                 1890             


Leu Tyr  Thr His Arg Pro His  Glu Ala Leu Ala Leu  Glu Val Ala 
    1895                 1900                 1905             


Leu Ser  Glu Arg Thr Tyr Arg  Ile Leu Glu Ala Leu  Ala Ala Ser 
    1910                 1915                 1920             


Asn Leu  Tyr Ser Val Ala Leu  Leu Glu Thr His Arg  Val Ala Leu 
    1925                 1930                 1935             


Gly Leu  Asn Thr His Arg Ile  Leu Glu Ala Ser Pro  Ala Ser Asn 
    1940                 1945                 1950             


Ala Leu  Ala Leu Glu Ser Glu  Arg Leu Tyr Ser Ala  Arg Gly Ala 
    1955                 1960                 1965             


Ser Asn  Gly Leu Leu Tyr Ser  Thr Arg Pro Ala Ser  Pro Gly Leu 
    1970                 1975                 1980             


Val Ala  Leu Thr Tyr Arg Leu  Tyr Ser Thr Tyr Arg  Ile Leu Glu 
    1985                 1990                 1995             


Val Ala  Leu Thr His Arg Ala  Ser Asn Thr Arg Pro  Leu Glu Ala 
    2000                 2005                 2010             


Leu Ala  Leu Tyr Ser Val Ala  Leu Ala Ser Asn Thr  His Arg Gly 
    2015                 2020                 2025             


Leu Asn  Ile Leu Glu Ala Ser  Pro Leu Glu Ile Leu  Glu Ala Arg 
    2030                 2035                 2040             


Gly Leu  Tyr Ser Leu Tyr Ser  Met Glu Thr Leu Tyr  Ser Gly Leu 
    2045                 2050                 2055             


Ala Leu  Ala Leu Glu Gly Leu  Ala Ser Asn Gly Leu  Asn Ala Leu 
    2060                 2065                 2070             


Ala Gly  Leu Ala Leu Ala Thr  His Arg Leu Tyr Ser  Ala Leu Ala 
    2075                 2080                 2085             


Ile Leu  Glu Ile Leu Glu Ala  Ser Asn Thr Tyr Arg  Gly Leu Asn 
    2090                 2095                 2100             


Thr Tyr  Arg Ala Ser Asn Gly  Leu Asn Thr Tyr Arg  Thr His Arg 
    2105                 2110                 2115             


Gly Leu  Gly Leu Gly Leu Leu  Tyr Ser Ala Ser Asn  Ala Ser Asn 
    2120                 2125                 2130             


Ile Leu  Glu Ala Ser Asn Pro  His Glu Ala Ser Asn  Ile Leu Glu 
    2135                 2140                 2145             


Ala Ser  Pro Ala Ser Pro Leu  Glu Ser Glu Arg Ser  Glu Arg Leu 
    2150                 2155                 2160             


Tyr Ser  Leu Glu Ala Ser Asn  Gly Leu Ser Glu Arg  Ile Leu Glu 
    2165                 2170                 2175             


Ala Ser  Asn Leu Tyr Ser Ala  Leu Ala Met Glu Thr  Ile Leu Glu 
    2180                 2185                 2190             


Ala Ser  Asn Ile Leu Glu Ala  Ser Asn Leu Tyr Ser  Pro His Glu 
    2195                 2200                 2205             


Leu Glu  Ala Ser Asn Gly Leu  Asn Cys Tyr Ser Ser  Glu Arg Val 
    2210                 2215                 2220             


Ala Leu  Ser Glu Arg Thr Tyr  Arg Leu Glu Met Glu  Thr Ala Ser 
    2225                 2230                 2235             


Asn Ser  Glu Arg Met Glu Thr  Ile Leu Glu Pro Arg  Thr Tyr Arg 
    2240                 2245                 2250             


Gly Leu  Tyr Val Ala Leu Leu  Tyr Ser Ala Arg Gly  Leu Glu Gly 
    2255                 2260                 2265             


Leu Ala  Ser Pro Pro His Glu  Ala Ser Pro Ala Leu  Ala Ser Glu 
    2270                 2275                 2280             


Arg Leu  Glu Leu Tyr Ser Ala  Ser Pro Ala Leu Ala  Leu Glu Leu 
    2285                 2290                 2295             


Glu Leu  Tyr Ser Thr Tyr Arg  Ile Leu Glu Thr Tyr  Arg Ala Ser 
    2300                 2305                 2310             


Pro Ala  Ser Asn Ala Arg Gly  Gly Leu Tyr Thr His  Arg Leu Glu 
    2315                 2320                 2325             


Ile Leu  Glu Gly Leu Tyr Gly  Leu Asn Val Ala Leu  Ala Ser Pro 
    2330                 2335                 2340             


Ala Arg  Gly Leu Glu Leu Tyr  Ser Ala Ser Pro Leu  Tyr Ser Val 
    2345                 2350                 2355             


Ala Leu  Ala Ser Asn Ala Ser  Asn Thr His Arg Leu  Glu Ser Glu 
    2360                 2365                 2370             


Arg Thr  His Arg Ala Ser Pro  Ile Leu Glu Pro Arg  Pro His Glu 
    2375                 2380                 2385             


Gly Leu  Asn Leu Glu Ser Glu  Arg Leu Tyr Ser Thr  Tyr Arg Val 
    2390                 2395                 2400             


Ala Leu  Ala Ser Pro Ala Ser  Asn Gly Leu Asn Ala  Arg Gly Leu 
    2405                 2410                 2415             


Glu Leu  Glu Ser Glu Arg Thr  His Arg Pro His Glu  Thr His Arg 
    2420                 2425                 2430             


Gly Leu  Thr Tyr Arg Ile Leu  Glu Leu Tyr Ser Ala  Ser Asn Ile 
    2435                 2440                 2445             


Leu Glu  Ile Leu Glu Ala Ser  Asn Thr His Arg Ser  Glu Arg Ile 
    2450                 2455                 2460             


Leu Glu  Leu Glu Ala Ser Asn  Leu Glu Ala Arg Gly  Thr Tyr Arg 
    2465                 2470                 2475             


Gly Leu  Ser Glu Arg Ala Ser  Asn His Ile Ser Leu  Glu Ile Leu 
    2480                 2485                 2490             


Glu Ala  Ser Pro Leu Glu Ser  Glu Arg Ala Arg Gly  Thr Tyr Arg 
    2495                 2500                 2505             


Ala Leu  Ala Ser Glu Arg Leu  Tyr Ser Ile Leu Glu  Ala Ser Asn 
    2510                 2515                 2520             


Ile Leu  Glu Gly Leu Tyr Ser  Glu Arg Leu Tyr Ser  Val Ala Leu 
    2525                 2530                 2535             


Ala Ser  Asn Pro His Glu Ala  Ser Pro Pro Arg Ile  Leu Glu Ala 
    2540                 2545                 2550             


Ser Pro  Leu Tyr Ser Ala Ser  Asn Gly Leu Asn Ile  Leu Glu Gly 
    2555                 2560                 2565             


Leu Asn  Leu Glu Pro His Glu  Ala Ser Asn Leu Glu  Gly Leu Ser 
    2570                 2575                 2580             


Glu Arg  Ser Glu Arg Leu Tyr  Ser Ile Leu Glu Gly  Leu Val Ala 
    2585                 2590                 2595             


Leu Ile  Leu Glu Leu Glu Leu  Tyr Ser Ala Ser Asn  Ala Leu Ala 
    2600                 2605                 2610             


Ile Leu  Glu Val Ala Leu Thr  Tyr Arg Ala Ser Asn  Ser Glu Arg 
    2615                 2620                 2625             


Met Glu  Thr Thr Tyr Arg Gly  Leu Ala Ser Asn Pro  His Glu Ser 
    2630                 2635                 2640             


Glu Arg  Thr His Arg Ser Glu  Arg Pro His Glu Thr  Arg Pro Ile 
    2645                 2650                 2655             


Leu Glu  Ala Arg Gly Ile Leu  Glu Pro Arg Leu Tyr  Ser Thr Tyr 
    2660                 2665                 2670             


Arg Pro  His Glu Ala Ser Asn  Ser Glu Arg Ile Leu  Glu Ser Glu 
    2675                 2680                 2685             


Arg Leu  Glu Ala Ser Asn Ala  Ser Asn Gly Leu Thr  Tyr Arg Thr 
    2690                 2695                 2700             


His Arg  Ile Leu Glu Ile Leu  Glu Ala Ser Asn Cys  Tyr Ser Met 
    2705                 2710                 2715             


Glu Thr  Gly Leu Ala Ser Asn  Ala Ser Asn Ser Glu  Arg Gly Leu 
    2720                 2725                 2730             


Tyr Thr  Arg Pro Leu Tyr Ser  Val Ala Leu Ser Glu  Arg Leu Glu 
    2735                 2740                 2745             


Ala Ser  Asn Thr Tyr Arg Gly  Leu Tyr Gly Leu Ile  Leu Glu Ile 
    2750                 2755                 2760             


Leu Glu  Thr Arg Pro Thr His  Arg Leu Glu Gly Leu  Asn Ala Ser 
    2765                 2770                 2775             


Pro Thr  His Arg Gly Leu Asn  Gly Leu Ile Leu Glu  Leu Tyr Ser 
    2780                 2785                 2790             


Gly Leu  Asn Ala Arg Gly Val  Ala Leu Val Ala Leu  Pro His Glu 
    2795                 2800                 2805             


Leu Tyr  Ser Thr Tyr Arg Ser  Glu Arg Gly Leu Asn  Met Glu Thr 
    2810                 2815                 2820             


Ile Leu  Glu Ala Ser Asn Ile  Leu Glu Ser Glu Arg  Ala Ser Pro 
    2825                 2830                 2835             


Thr Tyr  Arg Ile Leu Glu Ala  Ser Asn Ala Arg Gly  Thr Arg Pro 
    2840                 2845                 2850             


Ile Leu  Glu Pro His Glu Val  Ala Leu Thr His Arg  Ile Leu Glu 
    2855                 2860                 2865             


Thr His  Arg Ala Ser Asn Ala  Ser Asn Ala Arg Gly  Leu Glu Ala 
    2870                 2875                 2880             


Ser Asn  Ala Ser Asn Ser Glu  Arg Leu Tyr Ser Ile  Leu Glu Thr 
    2885                 2890                 2895             


Tyr Arg  Ile Leu Glu Ala Ser  Asn Gly Leu Tyr Ala  Arg Gly Leu 
    2900                 2905                 2910             


Glu Ile  Leu Glu Ala Ser Pro  Gly Leu Asn Leu Tyr  Ser Pro Arg 
    2915                 2920                 2925             


Ile Leu  Glu Ser Glu Arg Ala  Ser Asn Leu Glu Gly  Leu Tyr Ala 
    2930                 2935                 2940             


Ser Asn  Ile Leu Glu His Ile  Ser Ala Leu Ala Ser  Glu Arg Ala 
    2945                 2950                 2955             


Ser Asn  Ala Ser Asn Ile Leu  Glu Met Glu Thr Pro  His Glu Leu 
    2960                 2965                 2970             


Tyr Ser  Leu Glu Ala Ser Pro  Gly Leu Tyr Cys Tyr  Ser Ala Arg 
    2975                 2980                 2985             


Gly Ala  Ser Pro Thr His Arg  His Ile Ser Ala Arg  Gly Thr Tyr 
    2990                 2995                 3000             


Arg Ile  Leu Glu Thr Arg Pro  Ile Leu Glu Leu Tyr  Ser Thr Tyr 
    3005                 3010                 3015             


Arg Pro  His Glu Ala Ser Asn  Leu Glu Pro His Glu  Ala Ser Pro 
    3020                 3025                 3030             


Leu Tyr  Ser Gly Leu Leu Glu  Ala Ser Asn Gly Leu  Leu Tyr Ser 
    3035                 3040                 3045             


Gly Leu  Ile Leu Glu Leu Tyr  Ser Ala Ser Pro Leu  Glu Thr Tyr 
    3050                 3055                 3060             


Arg Ala  Ser Pro Ala Ser Asn  Gly Leu Asn Ser Glu  Arg Ala Ser 
    3065                 3070                 3075             


Asn Ser  Glu Arg Gly Leu Tyr  Ile Leu Glu Leu Glu  Leu Tyr Ser 
    3080                 3085                 3090             


Ala Ser  Pro Pro His Glu Thr  Arg Pro Gly Leu Tyr  Ala Ser Pro 
    3095                 3100                 3105             


Thr Tyr  Arg Leu Glu Gly Leu  Asn Thr Tyr Arg Ala  Ser Pro Leu 
    3110                 3115                 3120             


Tyr Ser  Pro Arg Thr Tyr Arg  Thr Tyr Arg Met Glu  Thr Leu Glu 
    3125                 3130                 3135             


Ala Ser  Asn Leu Glu Thr Tyr  Arg Ala Ser Pro Pro  Arg Ala Ser 
    3140                 3145                 3150             


Asn Leu  Tyr Ser Thr Tyr Arg  Val Ala Leu Ala Ser  Pro Val Ala 
    3155                 3160                 3165             


Leu Ala  Ser Asn Ala Ser Asn  Val Ala Leu Gly Leu  Tyr Ile Leu 
    3170                 3175                 3180             


Glu Ala  Arg Gly Gly Leu Tyr  Thr Tyr Arg Met Glu  Thr Thr Tyr 
    3185                 3190                 3195             


Arg Leu  Glu Leu Tyr Ser Gly  Leu Tyr Pro Arg Ala  Arg Gly Gly 
    3200                 3205                 3210             


Leu Tyr  Ser Glu Arg Val Ala  Leu Met Glu Thr Thr  His Arg Thr 
    3215                 3220                 3225             


His Arg  Ala Ser Asn Ile Leu  Glu Thr Tyr Arg Leu  Glu Ala Ser 
    3230                 3235                 3240             


Asn Ser  Glu Arg Ser Glu Arg  Leu Glu Thr Tyr Arg  Ala Arg Gly 
    3245                 3250                 3255             


Gly Leu  Tyr Thr His Arg Leu  Tyr Ser Pro His Glu  Ile Leu Glu 
    3260                 3265                 3270             


Ile Leu  Glu Leu Tyr Ser Leu  Tyr Ser Thr Tyr Arg  Ala Leu Ala 
    3275                 3280                 3285             


Ser Glu  Arg Gly Leu Tyr Ala  Ser Asn Leu Tyr Ser  Ala Ser Pro 
    3290                 3295                 3300             


Ala Ser  Asn Ile Leu Glu Val  Ala Leu Ala Arg Gly  Ala Ser Asn 
    3305                 3310                 3315             


Ala Ser  Asn Ala Ser Pro Ala  Arg Gly Val Ala Leu  Thr Tyr Arg 
    3320                 3325                 3330             


Ile Leu  Glu Ala Ser Asn Val  Ala Leu Val Ala Leu  Val Ala Leu 
    3335                 3340                 3345             


Leu Tyr  Ser Ala Ser Asn Leu  Tyr Ser Gly Leu Thr  Tyr Arg Ala 
    3350                 3355                 3360             


Arg Gly  Leu Glu Ala Leu Ala  Thr His Arg Ala Ser  Asn Ala Leu 
    3365                 3370                 3375             


Ala Ser  Glu Arg Gly Leu Asn  Ala Leu Ala Gly Leu  Tyr Val Ala 
    3380                 3385                 3390             


Leu Gly  Leu Leu Tyr Ser Ile  Leu Glu Leu Glu Ser  Glu Arg Ala 
    3395                 3400                 3405             


Leu Ala  Leu Glu Gly Leu Ile  Leu Glu Pro Arg Ala  Ser Pro Val 
    3410                 3415                 3420             


Ala Leu  Gly Leu Tyr Ala Ser  Asn Leu Glu Ser Glu  Arg Gly Leu 
    3425                 3430                 3435             


Asn Val  Ala Leu Val Ala Leu  Val Ala Leu Met Glu  Thr Leu Tyr 
    3440                 3445                 3450             


Ser Ser  Glu Arg Leu Tyr Ser  Ala Ser Asn Ala Ser  Pro Gly Leu 
    3455                 3460                 3465             


Asn Gly  Leu Tyr Ile Leu Glu  Thr His Arg Ala Ser  Asn Leu Tyr 
    3470                 3475                 3480             


Ser Cys  Tyr Ser Leu Tyr Ser  Met Glu Thr Ala Ser  Asn Leu Glu 
    3485                 3490                 3495             


Gly Leu  Asn Ala Ser Pro Ala  Ser Asn Ala Ser Asn  Gly Leu Tyr 
    3500                 3505                 3510             


Ala Ser  Asn Ala Ser Pro Ile  Leu Glu Gly Leu Tyr  Pro His Glu 
    3515                 3520                 3525             


Ile Leu  Glu Gly Leu Tyr Pro  His Glu His Ile Ser  Gly Leu Asn 
    3530                 3535                 3540             


Pro His  Glu Ala Ser Asn Ala  Ser Asn Ile Leu Glu  Ala Leu Ala 
    3545                 3550                 3555             


Leu Tyr  Ser Leu Glu Val Ala  Leu Ala Leu Ala Ser  Glu Arg Ala 
    3560                 3565                 3570             


Ser Asn  Thr Arg Pro Thr Tyr  Arg Ala Ser Asn Ala  Arg Gly Gly 
    3575                 3580                 3585             


Leu Asn  Ile Leu Glu Gly Leu  Ala Arg Gly Ser Glu  Arg Ser Glu 
    3590                 3595                 3600             


Arg Ala  Arg Gly Thr His Arg  Leu Glu Gly Leu Tyr  Cys Tyr Ser 
    3605                 3610                 3615             


Ser Glu  Arg Thr Arg Pro Gly  Leu Pro His Glu Ile  Leu Glu Pro 
    3620                 3625                 3630             


Arg Val  Ala Leu Ala Ser Pro  Ala Ser Pro Gly Leu  Tyr Thr Arg 
    3635                 3640                 3645             


Pro Gly  Leu Tyr Gly Leu Ala  Arg Gly Pro Arg Leu  Glu 
    3650                 3655                 3660     


<210>  3
<211>  3876
<212>  DNA
<213>  Clostridium botulinum

<400>  3
atgccagtta caataaataa ttttaattat aatgatccta ttgataataa taatattatt       60

atgatggagc ctccatttgc gagaggtacg gggagatatt ataaagcttt taaaatcaca      120

gatcgtattt ggataatacc ggaaagatat acttttggat ataaacctga ggattttaat      180

aaaagttccg gtatttttaa tagagatgtt tgtgaatatt atgatccaga ttacttaaat      240

actaatgata aaaagaatat atttttacaa acaatgatca agttatttaa tagaatcaaa      300

tcaaaaccat tgggtgaaaa gttattagag atgattataa atggtatacc ttatcttgga      360

gatagacgtg ttccactcga agagtttaac acaaacattg ctagtgtaac tgttaataaa      420

ttaatcagta atccaggaga agtggagcga aaaaaaggta ttttcgcaaa tttaataata      480

tttggacctg ggccagtttt aaatgaaaat gagactatag atataggtat acaaaatcat      540

tttgcatcaa gggaaggctt cgggggtata atgcaaatga agttttgccc agaatatgta      600

agcgtattta ataatgttca agaaaacaaa ggcgcaagta tatttaatag acgtggatat      660

ttttcagatc cagccttgat attaatgcat gaacttatac atgttttaca tggattatat      720

ggcattaaag tagatgattt accaattgta ccaaatgaaa aaaaattttt tatgcaatct      780

acagatgcta tacaggcaga agaactatat acatttggag gacaagatcc cagcatcata      840

actccttcta cggataaaag tatctatgat aaagttttgc aaaattttag agggatagtt      900

gatagactta acaaggtttt agtttgcata tcagatccta acattaatat taatatatat      960

aaaaataaat ttaaagataa atataaattc gttgaagatt ctgagggaaa atatagtata     1020

gatgtagaaa gttttgataa attatataaa agcttaatgt ttggttttac agaaactaat     1080

atagcagaaa attataaaat aaaaactaga gcttcttatt ttagtgattc cttaccacca     1140

gtaaaaataa aaaatttatt agataatgaa atctatacta tagaggaagg gtttaatata     1200

tctgataaag atatggaaaa agaatataga ggtcagaata aagctataaa taaacaagct     1260

tatgaagaaa ttagcaagga gcatttggct gtatataaga tacaaatgtg taaaagtgtt     1320

aaagctccag gaatatgtat tgatgttgat aatgaagatt tgttctttat agctgataaa     1380

aatagttttt cagatgattt atctaaaaac gaaagaatag aatataatac acagagtaat     1440

tatatagaaa atgacttccc tataaatgaa ttaattttag atactgattt aataagtaaa     1500

atagaattac caagtgaaaa tacagaatca cttactgatt ttaatgtaga tgttccagta     1560

tatgaaaaac aacccgctat aaaaaaaatt tttacagatg aaaataccat ctttcaatat     1620

ttatactctc agacatttcc tctagatata agagatataa gtttaacatc ttcatttgat     1680

gatgcattat tattttctaa caaagtttat tcattttttt ctatggatta tattaaaact     1740

gctaataaag tggtagaagc aggattattt gcaggttggg tgaaacagat agtaaatgat     1800

tttgtaatcg aagctaataa aagcaatact atggataaaa ttgcagatat atctctaatt     1860

gttccttata taggattagc tttaaatgta ggaaatgaaa cagctaaagg aaattttgaa     1920

aatgcttttg agattgcagg agccagtatt ctactagaat ttataccaga acttttaata     1980

cctgtagttg gagccttttt attagaatca tatattgaca ataaaaataa aattattaaa     2040

acaatagata atgctttaac taaaagaaat gaaaaatgga gtgatatgta cggattaata     2100

gtagcgcaat ggctctcaac agttaatact caattttata caataaaaga gggaatgtat     2160

aaggctttaa attatcaagc acaagcattg gaagaaataa taaaatacag atataatata     2220

tattctgaaa aagaaaagtc aaatattaac atcgatttta atgatataaa ttctaaactt     2280

aatgagggta ttaaccaagc tatagataat ataaataatt ttataaatgg atgttctgta     2340

tcatatttaa tgaaaaaaat gattccatta gctgtagaaa aattactaga ctttgataat     2400

actctcaaaa aaaatttgtt aaattatata gatgaaaata aattatattt gattggaagt     2460

gcagaatatg aaaaatcaaa agtaaataaa tacttgaaaa ccattatgcc gtttgatctt     2520

tcaatatata ccaatgatac aatactaata gaaatgttta ataaatataa tagcgaaatt     2580

ttaaataata ttatcttaaa tttaagatat aaggataata atttaataga tttatcagga     2640

tatggggcaa aggtagaggt atatgatgga gtcgagctta atgataaaaa tcaatttaaa     2700

ttaactagtt cagcaaatag taagattaga gtgactcaaa atcagaatat catatttaat     2760

agtgtgttcc ttgattttag cgttagcttt tggataagaa tacctaaata taagaatgat     2820

ggtatacaaa attatattca taatgaatat acaataatta attgtatgaa aaataattcg     2880

ggctggaaaa tatctattag gggtaatagg ataatatgga ctttaattga tataaatgga     2940

aaaaccaaat cggtattttt tgaatataac ataagagaag atatatcaga gtatataaat     3000

agatggtttt ttgtaactat tactaataat ttgaataacg ctaaaattta tattaatggt     3060

aagctagaat caaatacaga tattaaagat ataagagaag ttattgctaa tggtgaaata     3120

atatttaaat tagatggtga tatagataga acacaattta tttggatgaa atatttcagt     3180

atttttaata cggaattaag tcaatcaaat attgaagaaa gatataaaat tcaatcatat     3240

agcgaatatt taaaagattt ttggggaaat cctttaatgt acaataaaga atattatatg     3300

tttaatgcgg ggaataaaaa ttcatatatt aaactaaaga aagattcacc tgtaggtgaa     3360

attttaacac gtagcaaata taatcaaaat tctaaatata taaattatag agatttatat     3420

attggagaaa aatttattat aagaagaaag tcaaattctc aatctataaa tgatgatata     3480

gttagaaaag aagattatat atatctagat ttttttaatt taaatcaaga gtggagagta     3540

tatacctata aatattttaa gaaagaggaa gaaaaattgt ttttagctcc tataagtgat     3600

tctgatgagt tttacaatac tatacaaata aaagaatatg atgaacagcc aacatatagt     3660

tgtcagttgc tttttaaaaa agatgaagaa agtactgatg agataggatt gattggtatt     3720

catcgtttct acgaatctgg aattgtattt gaagagtata aagattattt ttgtataagt     3780

aaatggtact taaaagaggt aaaaaggaaa ccatataatt taaaattggg atgtaattgg     3840

cagtttattc ctaaagatga agggtggact gaataa                               3876


<210>  4
<211>  3642
<212>  PRT
<213>  Clostridium botulinum

<400>  4

Met Glu Thr Pro Arg Val Ala Leu Thr His Arg Ile Leu Glu Ala Ser 
1               5                   10                  15      


Asn Ala Ser Asn Pro His Glu Ala Ser Asn Thr Tyr Arg Ala Ser Asn 
            20                  25                  30          


Ala Ser Pro Pro Arg Ile Leu Glu Ala Ser Pro Ala Ser Asn Ala Ser 
        35                  40                  45              


Asn Ala Ser Asn Ile Leu Glu Ile Leu Glu Met Glu Thr Met Glu Thr 
    50                  55                  60                  


Gly Leu Pro Arg Pro Arg Pro His Glu Ala Leu Ala Ala Arg Gly Gly 
65                  70                  75                  80  


Leu Tyr Thr His Arg Gly Leu Tyr Ala Arg Gly Thr Tyr Arg Thr Tyr 
                85                  90                  95      


Arg Leu Tyr Ser Ala Leu Ala Pro His Glu Leu Tyr Ser Ile Leu Glu 
            100                 105                 110         


Thr His Arg Ala Ser Pro Ala Arg Gly Ile Leu Glu Thr Arg Pro Ile 
        115                 120                 125             


Leu Glu Ile Leu Glu Pro Arg Gly Leu Ala Arg Gly Thr Tyr Arg Thr 
    130                 135                 140                 


His Arg Pro His Glu Gly Leu Tyr Thr Tyr Arg Leu Tyr Ser Pro Arg 
145                 150                 155                 160 


Gly Leu Ala Ser Pro Pro His Glu Ala Ser Asn Leu Tyr Ser Ser Glu 
                165                 170                 175     


Arg Ser Glu Arg Gly Leu Tyr Ile Leu Glu Pro His Glu Ala Ser Asn 
            180                 185                 190         


Ala Arg Gly Ala Ser Pro Val Ala Leu Cys Tyr Ser Gly Leu Thr Tyr 
        195                 200                 205             


Arg Thr Tyr Arg Ala Ser Pro Pro Arg Ala Ser Pro Thr Tyr Arg Leu 
    210                 215                 220                 


Glu Ala Ser Asn Thr His Arg Ala Ser Asn Ala Ser Pro Leu Tyr Ser 
225                 230                 235                 240 


Leu Tyr Ser Ala Ser Asn Ile Leu Glu Pro His Glu Leu Glu Gly Leu 
                245                 250                 255     


Asn Thr His Arg Met Glu Thr Ile Leu Glu Leu Tyr Ser Leu Glu Pro 
            260                 265                 270         


His Glu Ala Ser Asn Ala Arg Gly Ile Leu Glu Leu Tyr Ser Ser Glu 
        275                 280                 285             


Arg Leu Tyr Ser Pro Arg Leu Glu Gly Leu Tyr Gly Leu Leu Tyr Ser 
    290                 295                 300                 


Leu Glu Leu Glu Gly Leu Met Glu Thr Ile Leu Glu Ile Leu Glu Ala 
305                 310                 315                 320 


Ser Asn Gly Leu Tyr Ile Leu Glu Pro Arg Thr Tyr Arg Leu Glu Gly 
                325                 330                 335     


Leu Tyr Ala Ser Pro Ala Arg Gly Ala Arg Gly Val Ala Leu Pro Arg 
            340                 345                 350         


Leu Glu Gly Leu Gly Leu Pro His Glu Ala Ser Asn Thr His Arg Ala 
        355                 360                 365             


Ser Asn Ile Leu Glu Ala Leu Ala Ser Glu Arg Val Ala Leu Thr His 
    370                 375                 380                 


Arg Val Ala Leu Ala Ser Asn Leu Tyr Ser Leu Glu Ile Leu Glu Ser 
385                 390                 395                 400 


Glu Arg Ala Ser Asn Pro Arg Gly Leu Tyr Gly Leu Val Ala Leu Gly 
                405                 410                 415     


Leu Ala Arg Gly Leu Tyr Ser Leu Tyr Ser Gly Leu Tyr Ile Leu Glu 
            420                 425                 430         


Pro His Glu Ala Leu Ala Ala Ser Asn Leu Glu Ile Leu Glu Ile Leu 
        435                 440                 445             


Glu Pro His Glu Gly Leu Tyr Pro Arg Gly Leu Tyr Pro Arg Val Ala 
    450                 455                 460                 


Leu Leu Glu Ala Ser Asn Gly Leu Ala Ser Asn Gly Leu Thr His Arg 
465                 470                 475                 480 


Ile Leu Glu Ala Ser Pro Ile Leu Glu Gly Leu Tyr Ile Leu Glu Gly 
                485                 490                 495     


Leu Asn Ala Ser Asn His Ile Ser Pro His Glu Ala Leu Ala Ser Glu 
            500                 505                 510         


Arg Ala Arg Gly Gly Leu Gly Leu Tyr Pro His Glu Gly Leu Tyr Gly 
        515                 520                 525             


Leu Tyr Ile Leu Glu Met Glu Thr Gly Leu Asn Met Glu Thr Leu Tyr 
    530                 535                 540                 


Ser Pro His Glu Cys Tyr Ser Pro Arg Gly Leu Thr Tyr Arg Val Ala 
545                 550                 555                 560 


Leu Ser Glu Arg Val Ala Leu Pro His Glu Ala Ser Asn Ala Ser Asn 
                565                 570                 575     


Val Ala Leu Gly Leu Asn Gly Leu Ala Ser Asn Leu Tyr Ser Gly Leu 
            580                 585                 590         


Tyr Ala Leu Ala Ser Glu Arg Ile Leu Glu Pro His Glu Ala Ser Asn 
        595                 600                 605             


Ala Arg Gly Ala Arg Gly Gly Leu Tyr Thr Tyr Arg Pro His Glu Ser 
    610                 615                 620                 


Glu Arg Ala Ser Pro Pro Arg Ala Leu Ala Leu Glu Ile Leu Glu Leu 
625                 630                 635                 640 


Glu Met Glu Thr His Ile Ser Gly Leu Leu Glu Ile Leu Glu His Ile 
                645                 650                 655     


Ser Val Ala Leu Leu Glu His Ile Ser Gly Leu Tyr Leu Glu Thr Tyr 
            660                 665                 670         


Arg Gly Leu Tyr Ile Leu Glu Leu Tyr Ser Val Ala Leu Ala Ser Pro 
        675                 680                 685             


Ala Ser Pro Leu Glu Pro Arg Ile Leu Glu Val Ala Leu Pro Arg Ala 
    690                 695                 700                 


Ser Asn Gly Leu Leu Tyr Ser Leu Tyr Ser Pro His Glu Pro His Glu 
705                 710                 715                 720 


Met Glu Thr Gly Leu Asn Ser Glu Arg Thr His Arg Ala Ser Pro Ala 
                725                 730                 735     


Leu Ala Ile Leu Glu Gly Leu Asn Ala Leu Ala Gly Leu Gly Leu Leu 
            740                 745                 750         


Glu Thr Tyr Arg Thr His Arg Pro His Glu Gly Leu Tyr Gly Leu Tyr 
        755                 760                 765             


Gly Leu Asn Ala Ser Pro Pro Arg Ser Glu Arg Ile Leu Glu Ile Leu 
    770                 775                 780                 


Glu Thr His Arg Pro Arg Ser Glu Arg Thr His Arg Ala Ser Pro Leu 
785                 790                 795                 800 


Tyr Ser Ser Glu Arg Ile Leu Glu Thr Tyr Arg Ala Ser Pro Leu Tyr 
                805                 810                 815     


Ser Val Ala Leu Leu Glu Gly Leu Asn Ala Ser Asn Pro His Glu Ala 
            820                 825                 830         


Arg Gly Gly Leu Tyr Ile Leu Glu Val Ala Leu Ala Ser Pro Ala Arg 
        835                 840                 845             


Gly Leu Glu Ala Ser Asn Leu Tyr Ser Val Ala Leu Leu Glu Val Ala 
    850                 855                 860                 


Leu Cys Tyr Ser Ile Leu Glu Ser Glu Arg Ala Ser Pro Pro Arg Ala 
865                 870                 875                 880 


Ser Asn Ile Leu Glu Ala Ser Asn Ile Leu Glu Ala Ser Asn Ile Leu 
                885                 890                 895     


Glu Thr Tyr Arg Leu Tyr Ser Ala Ser Asn Leu Tyr Ser Pro His Glu 
            900                 905                 910         


Leu Tyr Ser Ala Ser Pro Leu Tyr Ser Thr Tyr Arg Leu Tyr Ser Pro 
        915                 920                 925             


His Glu Val Ala Leu Gly Leu Ala Ser Pro Ser Glu Arg Gly Leu Gly 
    930                 935                 940                 


Leu Tyr Leu Tyr Ser Thr Tyr Arg Ser Glu Arg Ile Leu Glu Ala Ser 
945                 950                 955                 960 


Pro Val Ala Leu Gly Leu Ser Glu Arg Pro His Glu Ala Ser Pro Leu 
                965                 970                 975     


Tyr Ser Leu Glu Thr Tyr Arg Leu Tyr Ser Ser Glu Arg Leu Glu Met 
            980                 985                 990         


Glu Thr Pro His Glu Gly Leu Tyr  Pro His Glu Thr His  Arg Gly Leu 
        995                 1000                 1005             


Thr His  Arg Ala Ser Asn Ile  Leu Glu Ala Leu Ala  Gly Leu Ala 
    1010                 1015                 1020             


Ser Asn  Thr Tyr Arg Leu Tyr  Ser Ile Leu Glu Leu  Tyr Ser Thr 
    1025                 1030                 1035             


His Arg  Ala Arg Gly Ala Leu  Ala Ser Glu Arg Thr  Tyr Arg Pro 
    1040                 1045                 1050             


His Glu  Ser Glu Arg Ala Ser  Pro Ser Glu Arg Leu  Glu Pro Arg 
    1055                 1060                 1065             


Pro Arg  Val Ala Leu Leu Tyr  Ser Ile Leu Glu Leu  Tyr Ser Ala 
    1070                 1075                 1080             


Ser Asn  Leu Glu Leu Glu Ala  Ser Pro Ala Ser Asn  Gly Leu Ile 
    1085                 1090                 1095             


Leu Glu  Thr Tyr Arg Thr His  Arg Ile Leu Glu Gly  Leu Gly Leu 
    1100                 1105                 1110             


Gly Leu  Tyr Pro His Glu Ala  Ser Asn Ile Leu Glu  Ser Glu Arg 
    1115                 1120                 1125             


Ala Ser  Pro Leu Tyr Ser Ala  Ser Pro Met Glu Thr  Gly Leu Leu 
    1130                 1135                 1140             


Tyr Ser  Gly Leu Thr Tyr Arg  Ala Arg Gly Gly Leu  Tyr Gly Leu 
    1145                 1150                 1155             


Asn Ala  Ser Asn Leu Tyr Ser  Ala Leu Ala Ile Leu  Glu Ala Ser 
    1160                 1165                 1170             


Asn Leu  Tyr Ser Gly Leu Asn  Ala Leu Ala Thr Tyr  Arg Gly Leu 
    1175                 1180                 1185             


Gly Leu  Ile Leu Glu Ser Glu  Arg Leu Tyr Ser Gly  Leu His Ile 
    1190                 1195                 1200             


Ser Leu  Glu Ala Leu Ala Val  Ala Leu Thr Tyr Arg  Leu Tyr Ser 
    1205                 1210                 1215             


Ile Leu  Glu Gly Leu Asn Met  Glu Thr Cys Tyr Ser  Leu Tyr Ser 
    1220                 1225                 1230             


Ser Glu  Arg Val Ala Leu Leu  Tyr Ser Ala Leu Ala  Pro Arg Gly 
    1235                 1240                 1245             


Leu Tyr  Ile Leu Glu Cys Tyr  Ser Ile Leu Glu Ala  Ser Pro Val 
    1250                 1255                 1260             


Ala Leu  Ala Ser Pro Ala Ser  Asn Gly Leu Ala Ser  Pro Leu Glu 
    1265                 1270                 1275             


Pro His  Glu Pro His Glu Ile  Leu Glu Ala Leu Ala  Ala Ser Pro 
    1280                 1285                 1290             


Leu Tyr  Ser Ala Ser Asn Ser  Glu Arg Pro His Glu  Ser Glu Arg 
    1295                 1300                 1305             


Ala Ser  Pro Ala Ser Pro Leu  Glu Ser Glu Arg Leu  Tyr Ser Ala 
    1310                 1315                 1320             


Ser Asn  Gly Leu Ala Arg Gly  Ile Leu Glu Gly Leu  Thr Tyr Arg 
    1325                 1330                 1335             


Ala Ser  Asn Thr His Arg Gly  Leu Asn Ser Glu Arg  Ala Ser Asn 
    1340                 1345                 1350             


Thr Tyr  Arg Ile Leu Glu Gly  Leu Ala Ser Asn Ala  Ser Pro Pro 
    1355                 1360                 1365             


His Glu  Pro Arg Ile Leu Glu  Ala Ser Asn Gly Leu  Leu Glu Ile 
    1370                 1375                 1380             


Leu Glu  Leu Glu Ala Ser Pro  Thr His Arg Ala Ser  Pro Leu Glu 
    1385                 1390                 1395             


Ile Leu  Glu Ser Glu Arg Leu  Tyr Ser Ile Leu Glu  Gly Leu Leu 
    1400                 1405                 1410             


Glu Pro  Arg Ser Glu Arg Gly  Leu Ala Ser Asn Thr  His Arg Gly 
    1415                 1420                 1425             


Leu Ser  Glu Arg Leu Glu Thr  His Arg Ala Ser Pro  Pro His Glu 
    1430                 1435                 1440             


Ala Ser  Asn Val Ala Leu Ala  Ser Pro Val Ala Leu  Pro Arg Val 
    1445                 1450                 1455             


Ala Leu  Thr Tyr Arg Gly Leu  Leu Tyr Ser Gly Leu  Asn Pro Arg 
    1460                 1465                 1470             


Ala Leu  Ala Ile Leu Glu Leu  Tyr Ser Leu Tyr Ser  Ile Leu Glu 
    1475                 1480                 1485             


Pro His  Glu Thr His Arg Ala  Ser Pro Gly Leu Ala  Ser Asn Thr 
    1490                 1495                 1500             


His Arg  Ile Leu Glu Pro His  Glu Gly Leu Asn Thr  Tyr Arg Leu 
    1505                 1510                 1515             


Glu Thr  Tyr Arg Ser Glu Arg  Gly Leu Asn Thr His  Arg Pro His 
    1520                 1525                 1530             


Glu Pro  Arg Leu Glu Ala Ser  Pro Ile Leu Glu Ala  Arg Gly Ala 
    1535                 1540                 1545             


Ser Pro  Ile Leu Glu Ser Glu  Arg Leu Glu Thr His  Arg Ser Glu 
    1550                 1555                 1560             


Arg Ser  Glu Arg Pro His Glu  Ala Ser Pro Ala Ser  Pro Ala Leu 
    1565                 1570                 1575             


Ala Leu  Glu Leu Glu Pro His  Glu Ser Glu Arg Ala  Ser Asn Leu 
    1580                 1585                 1590             


Tyr Ser  Val Ala Leu Thr Tyr  Arg Ser Glu Arg Pro  His Glu Pro 
    1595                 1600                 1605             


His Glu  Ser Glu Arg Met Glu  Thr Ala Ser Pro Thr  Tyr Arg Ile 
    1610                 1615                 1620             


Leu Glu  Leu Tyr Ser Thr His  Arg Ala Leu Ala Ala  Ser Asn Leu 
    1625                 1630                 1635             


Tyr Ser  Val Ala Leu Val Ala  Leu Gly Leu Ala Leu  Ala Gly Leu 
    1640                 1645                 1650             


Tyr Leu  Glu Pro His Glu Ala  Leu Ala Gly Leu Tyr  Thr Arg Pro 
    1655                 1660                 1665             


Val Ala  Leu Leu Tyr Ser Gly  Leu Asn Ile Leu Glu  Val Ala Leu 
    1670                 1675                 1680             


Ala Ser  Asn Ala Ser Pro Pro  His Glu Val Ala Leu  Ile Leu Glu 
    1685                 1690                 1695             


Gly Leu  Ala Leu Ala Ala Ser  Asn Leu Tyr Ser Ser  Glu Arg Ala 
    1700                 1705                 1710             


Ser Asn  Thr His Arg Met Glu  Thr Ala Ser Pro Leu  Tyr Ser Ile 
    1715                 1720                 1725             


Leu Glu  Ala Leu Ala Ala Ser  Pro Ile Leu Glu Ser  Glu Arg Leu 
    1730                 1735                 1740             


Glu Ile  Leu Glu Val Ala Leu  Pro Arg Thr Tyr Arg  Ile Leu Glu 
    1745                 1750                 1755             


Gly Leu  Tyr Leu Glu Ala Leu  Ala Leu Glu Ala Ser  Asn Val Ala 
    1760                 1765                 1770             


Leu Gly  Leu Tyr Ala Ser Asn  Gly Leu Thr His Arg  Ala Leu Ala 
    1775                 1780                 1785             


Leu Tyr  Ser Gly Leu Tyr Ala  Ser Asn Pro His Glu  Gly Leu Ala 
    1790                 1795                 1800             


Ser Asn  Ala Leu Ala Pro His  Glu Gly Leu Ile Leu  Glu Ala Leu 
    1805                 1810                 1815             


Ala Gly  Leu Tyr Ala Leu Ala  Ser Glu Arg Ile Leu  Glu Leu Glu 
    1820                 1825                 1830             


Leu Glu  Gly Leu Pro His Glu  Ile Leu Glu Pro Arg  Gly Leu Leu 
    1835                 1840                 1845             


Glu Leu  Glu Ile Leu Glu Pro  Arg Val Ala Leu Val  Ala Leu Gly 
    1850                 1855                 1860             


Leu Tyr  Ala Leu Ala Pro His  Glu Leu Glu Leu Glu  Gly Leu Ser 
    1865                 1870                 1875             


Glu Arg  Thr Tyr Arg Ile Leu  Glu Ala Ser Pro Ala  Ser Asn Leu 
    1880                 1885                 1890             


Tyr Ser  Ala Ser Asn Leu Tyr  Ser Ile Leu Glu Ile  Leu Glu Leu 
    1895                 1900                 1905             


Tyr Ser  Thr His Arg Ile Leu  Glu Ala Ser Pro Ala  Ser Asn Ala 
    1910                 1915                 1920             


Leu Ala  Leu Glu Thr His Arg  Leu Tyr Ser Ala Arg  Gly Ala Ser 
    1925                 1930                 1935             


Asn Gly  Leu Leu Tyr Ser Thr  Arg Pro Ser Glu Arg  Ala Ser Pro 
    1940                 1945                 1950             


Met Glu  Thr Thr Tyr Arg Gly  Leu Tyr Leu Glu Ile  Leu Glu Val 
    1955                 1960                 1965             


Ala Leu  Ala Leu Ala Gly Leu  Asn Thr Arg Pro Leu  Glu Ser Glu 
    1970                 1975                 1980             


Arg Thr  His Arg Val Ala Leu  Ala Ser Asn Thr His  Arg Gly Leu 
    1985                 1990                 1995             


Asn Pro  His Glu Thr Tyr Arg  Thr His Arg Ile Leu  Glu Leu Tyr 
    2000                 2005                 2010             


Ser Gly  Leu Gly Leu Tyr Met  Glu Thr Thr Tyr Arg  Leu Tyr Ser 
    2015                 2020                 2025             


Ala Leu  Ala Leu Glu Ala Ser  Asn Thr Tyr Arg Gly  Leu Asn Ala 
    2030                 2035                 2040             


Leu Ala  Gly Leu Asn Ala Leu  Ala Leu Glu Gly Leu  Gly Leu Ile 
    2045                 2050                 2055             


Leu Glu  Ile Leu Glu Leu Tyr  Ser Thr Tyr Arg Ala  Arg Gly Thr 
    2060                 2065                 2070             


Tyr Arg  Ala Ser Asn Ile Leu  Glu Thr Tyr Arg Ser  Glu Arg Gly 
    2075                 2080                 2085             


Leu Leu  Tyr Ser Gly Leu Leu  Tyr Ser Ser Glu Arg  Ala Ser Asn 
    2090                 2095                 2100             


Ile Leu  Glu Ala Ser Asn Ile  Leu Glu Ala Ser Pro  Pro His Glu 
    2105                 2110                 2115             


Ala Ser  Asn Ala Ser Pro Ile  Leu Glu Ala Ser Asn  Ser Glu Arg 
    2120                 2125                 2130             


Leu Tyr  Ser Leu Glu Ala Ser  Asn Gly Leu Gly Leu  Tyr Ile Leu 
    2135                 2140                 2145             


Glu Ala  Ser Asn Gly Leu Asn  Ala Leu Ala Ile Leu  Glu Ala Ser 
    2150                 2155                 2160             


Pro Ala  Ser Asn Ile Leu Glu  Ala Ser Asn Ala Ser  Asn Pro His 
    2165                 2170                 2175             


Glu Ile  Leu Glu Ala Ser Asn  Gly Leu Tyr Cys Tyr  Ser Ser Glu 
    2180                 2185                 2190             


Arg Val  Ala Leu Ser Glu Arg  Thr Tyr Arg Leu Glu  Met Glu Thr 
    2195                 2200                 2205             


Leu Tyr  Ser Leu Tyr Ser Met  Glu Thr Ile Leu Glu  Pro Arg Leu 
    2210                 2215                 2220             


Glu Ala  Leu Ala Val Ala Leu  Gly Leu Leu Tyr Ser  Leu Glu Leu 
    2225                 2230                 2235             


Glu Ala  Ser Pro Pro His Glu  Ala Ser Pro Ala Ser  Asn Thr His 
    2240                 2245                 2250             


Arg Leu  Glu Leu Tyr Ser Leu  Tyr Ser Ala Ser Asn  Leu Glu Leu 
    2255                 2260                 2265             


Glu Ala  Ser Asn Thr Tyr Arg  Ile Leu Glu Ala Ser  Pro Gly Leu 
    2270                 2275                 2280             


Ala Ser  Asn Leu Tyr Ser Leu  Glu Thr Tyr Arg Leu  Glu Ile Leu 
    2285                 2290                 2295             


Glu Gly  Leu Tyr Ser Glu Arg  Ala Leu Ala Gly Leu  Thr Tyr Arg 
    2300                 2305                 2310             


Gly Leu  Leu Tyr Ser Ser Glu  Arg Leu Tyr Ser Val  Ala Leu Ala 
    2315                 2320                 2325             


Ser Asn  Leu Tyr Ser Thr Tyr  Arg Leu Glu Leu Tyr  Ser Thr His 
    2330                 2335                 2340             


Arg Ile  Leu Glu Met Glu Thr  Pro Arg Pro His Glu  Ala Ser Pro 
    2345                 2350                 2355             


Leu Glu  Ser Glu Arg Ile Leu  Glu Thr Tyr Arg Thr  His Arg Ala 
    2360                 2365                 2370             


Ser Asn  Ala Ser Pro Thr His  Arg Ile Leu Glu Leu  Glu Ile Leu 
    2375                 2380                 2385             


Glu Gly  Leu Met Glu Thr Pro  His Glu Ala Ser Asn  Leu Tyr Ser 
    2390                 2395                 2400             


Thr Tyr  Arg Ala Ser Asn Ser  Glu Arg Gly Leu Ile  Leu Glu Leu 
    2405                 2410                 2415             


Glu Ala  Ser Asn Ala Ser Asn  Ile Leu Glu Ile Leu  Glu Leu Glu 
    2420                 2425                 2430             


Ala Ser  Asn Leu Glu Ala Arg  Gly Thr Tyr Arg Leu  Tyr Ser Ala 
    2435                 2440                 2445             


Ser Pro  Ala Ser Asn Ala Ser  Asn Leu Glu Ile Leu  Glu Ala Ser 
    2450                 2455                 2460             


Pro Leu  Glu Ser Glu Arg Gly  Leu Tyr Thr Tyr Arg  Gly Leu Tyr 
    2465                 2470                 2475             


Ala Leu  Ala Leu Tyr Ser Val  Ala Leu Gly Leu Val  Ala Leu Thr 
    2480                 2485                 2490             


Tyr Arg  Ala Ser Pro Gly Leu  Tyr Val Ala Leu Gly  Leu Leu Glu 
    2495                 2500                 2505             


Ala Ser  Asn Ala Ser Pro Leu  Tyr Ser Ala Ser Asn  Gly Leu Asn 
    2510                 2515                 2520             


Pro His  Glu Leu Tyr Ser Leu  Glu Thr His Arg Ser  Glu Arg Ser 
    2525                 2530                 2535             


Glu Arg  Ala Leu Ala Ala Ser  Asn Ser Glu Arg Leu  Tyr Ser Ile 
    2540                 2545                 2550             


Leu Glu  Ala Arg Gly Val Ala  Leu Thr His Arg Gly  Leu Asn Ala 
    2555                 2560                 2565             


Ser Asn  Gly Leu Asn Ala Ser  Asn Ile Leu Glu Ile  Leu Glu Pro 
    2570                 2575                 2580             


His Glu  Ala Ser Asn Ser Glu  Arg Val Ala Leu Pro  His Glu Leu 
    2585                 2590                 2595             


Glu Ala  Ser Pro Pro His Glu  Ser Glu Arg Val Ala  Leu Ser Glu 
    2600                 2605                 2610             


Arg Pro  His Glu Thr Arg Pro  Ile Leu Glu Ala Arg  Gly Ile Leu 
    2615                 2620                 2625             


Glu Pro  Arg Leu Tyr Ser Thr  Tyr Arg Leu Tyr Ser  Ala Ser Asn 
    2630                 2635                 2640             


Ala Ser  Pro Gly Leu Tyr Ile  Leu Glu Gly Leu Asn  Ala Ser Asn 
    2645                 2650                 2655             


Thr Tyr  Arg Ile Leu Glu His  Ile Ser Ala Ser Asn  Gly Leu Thr 
    2660                 2665                 2670             


Tyr Arg  Thr His Arg Ile Leu  Glu Ile Leu Glu Ala  Ser Asn Cys 
    2675                 2680                 2685             


Tyr Ser  Met Glu Thr Leu Tyr  Ser Ala Ser Asn Ala  Ser Asn Ser 
    2690                 2695                 2700             


Glu Arg  Gly Leu Tyr Thr Arg  Pro Leu Tyr Ser Ile  Leu Glu Ser 
    2705                 2710                 2715             


Glu Arg  Ile Leu Glu Ala Arg  Gly Gly Leu Tyr Ala  Ser Asn Ala 
    2720                 2725                 2730             


Arg Gly  Ile Leu Glu Ile Leu  Glu Thr Arg Pro Thr  His Arg Leu 
    2735                 2740                 2745             


Glu Ile  Leu Glu Ala Ser Pro  Ile Leu Glu Ala Ser  Asn Gly Leu 
    2750                 2755                 2760             


Tyr Leu  Tyr Ser Thr His Arg  Leu Tyr Ser Ser Glu  Arg Val Ala 
    2765                 2770                 2775             


Leu Pro  His Glu Pro His Glu  Gly Leu Thr Tyr Arg  Ala Ser Asn 
    2780                 2785                 2790             


Ile Leu  Glu Ala Arg Gly Gly  Leu Ala Ser Pro Ile  Leu Glu Ser 
    2795                 2800                 2805             


Glu Arg  Gly Leu Thr Tyr Arg  Ile Leu Glu Ala Ser  Asn Ala Arg 
    2810                 2815                 2820             


Gly Thr  Arg Pro Pro His Glu  Pro His Glu Val Ala  Leu Thr His 
    2825                 2830                 2835             


Arg Ile  Leu Glu Thr His Arg  Ala Ser Asn Ala Ser  Asn Leu Glu 
    2840                 2845                 2850             


Ala Ser  Asn Ala Ser Asn Ala  Leu Ala Leu Tyr Ser  Ile Leu Glu 
    2855                 2860                 2865             


Thr Tyr  Arg Ile Leu Glu Ala  Ser Asn Gly Leu Tyr  Leu Tyr Ser 
    2870                 2875                 2880             


Leu Glu  Gly Leu Ser Glu Arg  Ala Ser Asn Thr His  Arg Ala Ser 
    2885                 2890                 2895             


Pro Ile  Leu Glu Leu Tyr Ser  Ala Ser Pro Ile Leu  Glu Ala Arg 
    2900                 2905                 2910             


Gly Gly  Leu Val Ala Leu Ile  Leu Glu Ala Leu Ala  Ala Ser Asn 
    2915                 2920                 2925             


Gly Leu  Tyr Gly Leu Ile Leu  Glu Ile Leu Glu Pro  His Glu Leu 
    2930                 2935                 2940             


Tyr Ser  Leu Glu Ala Ser Pro  Gly Leu Tyr Ala Ser  Pro Ile Leu 
    2945                 2950                 2955             


Glu Ala  Ser Pro Ala Arg Gly  Thr His Arg Gly Leu  Asn Pro His 
    2960                 2965                 2970             


Glu Ile  Leu Glu Thr Arg Pro  Met Glu Thr Leu Tyr  Ser Thr Tyr 
    2975                 2980                 2985             


Arg Pro  His Glu Ser Glu Arg  Ile Leu Glu Pro His  Glu Ala Ser 
    2990                 2995                 3000             


Asn Thr  His Arg Gly Leu Leu  Glu Ser Glu Arg Gly  Leu Asn Ser 
    3005                 3010                 3015             


Glu Arg  Ala Ser Asn Ile Leu  Glu Gly Leu Gly Leu  Ala Arg Gly 
    3020                 3025                 3030             


Thr Tyr  Arg Leu Tyr Ser Ile  Leu Glu Gly Leu Asn  Ser Glu Arg 
    3035                 3040                 3045             


Thr Tyr  Arg Ser Glu Arg Gly  Leu Thr Tyr Arg Leu  Glu Leu Tyr 
    3050                 3055                 3060             


Ser Ala  Ser Pro Pro His Glu  Thr Arg Pro Gly Leu  Tyr Ala Ser 
    3065                 3070                 3075             


Asn Pro  Arg Leu Glu Met Glu  Thr Thr Tyr Arg Ala  Ser Asn Leu 
    3080                 3085                 3090             


Tyr Ser  Gly Leu Thr Tyr Arg  Thr Tyr Arg Met Glu  Thr Pro His 
    3095                 3100                 3105             


Glu Ala  Ser Asn Ala Leu Ala  Gly Leu Tyr Ala Ser  Asn Leu Tyr 
    3110                 3115                 3120             


Ser Ala  Ser Asn Ser Glu Arg  Thr Tyr Arg Ile Leu  Glu Leu Tyr 
    3125                 3130                 3135             


Ser Leu  Glu Leu Tyr Ser Leu  Tyr Ser Ala Ser Pro  Ser Glu Arg 
    3140                 3145                 3150             


Pro Arg  Val Ala Leu Gly Leu  Tyr Gly Leu Ile Leu  Glu Leu Glu 
    3155                 3160                 3165             


Thr His  Arg Ala Arg Gly Ser  Glu Arg Leu Tyr Ser  Thr Tyr Arg 
    3170                 3175                 3180             


Ala Ser  Asn Gly Leu Asn Ala  Ser Asn Ser Glu Arg  Leu Tyr Ser 
    3185                 3190                 3195             


Thr Tyr  Arg Ile Leu Glu Ala  Ser Asn Thr Tyr Arg  Ala Arg Gly 
    3200                 3205                 3210             


Ala Ser  Pro Leu Glu Thr Tyr  Arg Ile Leu Glu Gly  Leu Tyr Gly 
    3215                 3220                 3225             


Leu Leu  Tyr Ser Pro His Glu  Ile Leu Glu Ile Leu  Glu Ala Arg 
    3230                 3235                 3240             


Gly Ala  Arg Gly Leu Tyr Ser  Ser Glu Arg Ala Ser  Asn Ser Glu 
    3245                 3250                 3255             


Arg Gly  Leu Asn Ser Glu Arg  Ile Leu Glu Ala Ser  Asn Ala Ser 
    3260                 3265                 3270             


Pro Ala  Ser Pro Ile Leu Glu  Val Ala Leu Ala Arg  Gly Leu Tyr 
    3275                 3280                 3285             


Ser Gly  Leu Ala Ser Pro Thr  Tyr Arg Ile Leu Glu  Thr Tyr Arg 
    3290                 3295                 3300             


Leu Glu  Ala Ser Pro Pro His  Glu Pro His Glu Ala  Ser Asn Leu 
    3305                 3310                 3315             


Glu Ala  Ser Asn Gly Leu Asn  Gly Leu Thr Arg Pro  Ala Arg Gly 
    3320                 3325                 3330             


Val Ala  Leu Thr Tyr Arg Thr  His Arg Thr Tyr Arg  Leu Tyr Ser 
    3335                 3340                 3345             


Thr Tyr  Arg Pro His Glu Leu  Tyr Ser Leu Tyr Ser  Gly Leu Gly 
    3350                 3355                 3360             


Leu Gly  Leu Leu Tyr Ser Leu  Glu Pro His Glu Leu  Glu Ala Leu 
    3365                 3370                 3375             


Ala Pro  Arg Ile Leu Glu Ser  Glu Arg Ala Ser Pro  Ser Glu Arg 
    3380                 3385                 3390             


Ala Ser  Pro Gly Leu Pro His  Glu Thr Tyr Arg Ala  Ser Asn Thr 
    3395                 3400                 3405             


His Arg  Ile Leu Glu Gly Leu  Asn Ile Leu Glu Leu  Tyr Ser Gly 
    3410                 3415                 3420             


Leu Thr  Tyr Arg Ala Ser Pro  Gly Leu Gly Leu Asn  Pro Arg Thr 
    3425                 3430                 3435             


His Arg  Thr Tyr Arg Ser Glu  Arg Cys Tyr Ser Gly  Leu Asn Leu 
    3440                 3445                 3450             


Glu Leu  Glu Pro His Glu Leu  Tyr Ser Leu Tyr Ser  Ala Ser Pro 
    3455                 3460                 3465             


Gly Leu  Gly Leu Ser Glu Arg  Thr His Arg Ala Ser  Pro Gly Leu 
    3470                 3475                 3480             


Ile Leu  Glu Gly Leu Tyr Leu  Glu Ile Leu Glu Gly  Leu Tyr Ile 
    3485                 3490                 3495             


Leu Glu  His Ile Ser Ala Arg  Gly Pro His Glu Thr  Tyr Arg Gly 
    3500                 3505                 3510             


Leu Ser  Glu Arg Gly Leu Tyr  Ile Leu Glu Val Ala  Leu Pro His 
    3515                 3520                 3525             


Glu Gly  Leu Gly Leu Thr Tyr  Arg Leu Tyr Ser Ala  Ser Pro Thr 
    3530                 3535                 3540             


Tyr Arg  Pro His Glu Cys Tyr  Ser Ile Leu Glu Ser  Glu Arg Leu 
    3545                 3550                 3555             


Tyr Ser  Thr Arg Pro Thr Tyr  Arg Leu Glu Leu Tyr  Ser Gly Leu 
    3560                 3565                 3570             


Val Ala  Leu Leu Tyr Ser Ala  Arg Gly Leu Tyr Ser  Pro Arg Thr 
    3575                 3580                 3585             


Tyr Arg  Ala Ser Asn Leu Glu  Leu Tyr Ser Leu Glu  Gly Leu Tyr 
    3590                 3595                 3600             


Cys Tyr  Ser Ala Ser Asn Thr  Arg Pro Gly Leu Asn  Pro His Glu 
    3605                 3610                 3615             


Ile Leu  Glu Pro Arg Leu Tyr  Ser Ala Ser Pro Gly  Leu Gly Leu 
    3620                 3625                 3630             


Tyr Thr  Arg Pro Thr His Arg  Gly Leu 
    3635                 3640         


<210>  5
<211>  3843
<212>  DNA
<213>  Clostridium botulinum

<400>  5
atgccaataa caattaacaa ctttaattat tcagatcctg ttgataataa aaatatttta       60

tatttagata ctcatttaaa tacattagct aatgagcctg aaaaagcctt tcgcattata      120

gggaatatat gggtaatacc cgatagattt tcaagagatt ctaatccaaa tttaaataaa      180

cctcctcgag ttacaagccc taaaagtggt tattatgatc ctaattattt gagtactgat      240

tctgaaaaag atacattttt aaaagaaatt ataaagttat ttaaaagaat taactctaga      300

gaaataggag aagaattaat atatagactt gcaacagaca taccctttcc tgggaataac      360

aatactccaa ttaatacttt tgattttgat gtagatttta acagtgttga tgttaaaact      420

agacaaggta acaactgggt taaaactggt agtataaatc ctagtgttat aataactgga      480

cctagagaaa acattataga cccagaaact tctacgttta aattaactaa caatactttt      540

gcggcacaag aaggatttgg tgctttatca ataatttcaa tatcacctag atttatgcta      600

acatatagta atgcaactaa taatgtagga gagggtagat tttctaagtc tgaattttgc      660

atggatccaa tactaatttt aatgcatgaa cttaatcatg caatgcataa tttatatgga      720

atagctatac caaatgatca aagaatttca tctgtaacta gtaatatttt ttattctcaa      780

tataaggtga aattagagta tgcagaaata tatgcatttg gaggtccaac tatagacctt      840

attcctaaaa gtgcaaggaa atattttgag gaaaaggcat tggattatta tagatccata      900

gctaaaagac ttaatagtat aactactgca aatccttcaa gctttaataa atatatagga      960

gaatataaac agaaacttat tagaaagtat agattcgtag tagaatcttc aggtgaagtt     1020

gcagtagatc gtaataagtt tgctgagtta tataaagaac ttacacaaat atttacagaa     1080

tttaactacg ctaaaatata taatgtacaa aataggaaaa tatatctttc aaatgtatat     1140

actccggtta cggcaaatat attagacgat aatgtttatg atatacaaaa tggatttaac     1200

atacctaaaa gtaatttaaa tgtactattt atgggtcaaa atttatctcg aaatccagca     1260

ttaagaaaag tcaatcctga aaatatgctt tatttattta caaaattttg ccataaagca     1320

atagatggta gatcattata taataaaaca ttagattgta gagagctttt agttaaaaat     1380

actgacttac cctttatagg tgatattagt gatatcaaaa ctgatatatt tttaagcaaa     1440

gatattaatg aagaaactga agttatagac tatccggaca atgtttcagt ggatcaagtt     1500

attctcagta agaatacctc agaacatgga caactagatt tattataccc tattattgaa     1560

ggtgagagtc aagtattacc gggagagaat caagtctttt atgataatag aactcaaaat     1620

gttgattatt tgaattctta ttattaccta gaatctcaaa aactaagtga taatgttgaa     1680

gattttactt ttacgacatc aattgaggaa gctttggata atagtggaaa agtatatact     1740

tactttccta aactagctga taaagtaaat acgggtgttc aaggtggttt atttttaatg     1800

tgggcaaatg atgtagttga agattttact acaaatattc taagaaaaga tacattagat     1860

aaaatatcag atgtatcagc tattattccc tatataggac ctgcattaaa tataagtaat     1920

tctgtaagaa ggggaaattt tactgaagca tttgcagtta ccggtgtaac tattttatta     1980

gaagcgtttc aagaatttac aatacctgca cttggtgcat ttgtgattta tagtaaggtt     2040

caagaaagaa acgagattat taaaactata gataattgtt tagaacaaag gattaaaaga     2100

tggaaagatt catatgaatg gatgatagga acgtggttat ccaggattac tactcaattt     2160

aataatataa gttatcaaat gtatgattct ttaaattatc aggcagatgc aatcaaagat     2220

aaaatagatt tagaatataa aaaatactca ggaagtgata aagaaaatat aaaaagtcaa     2280

gttgaaaatt taaaaaatag tttagatata aaaatctcgg aagcaatgaa taatataaat     2340

aaatttatac gagaatgttc tgtaacatac ttatttaaaa atatgctccc taaagtaatt     2400

gatgaattaa ataagtttga tttaaaaact aaaacagaat taattaatct tatagatagt     2460

cataatatta ttctagttgg tgaagtagat agattaaaag caaaagtaaa tgagagtttt     2520

gaaaatacaa taccctttaa tattttttca tatactaata attctttatt aaaagatata     2580

attaatgaat atttcaatag tattaatgat tcaaaaattt tgagcttaca aaacaaaaaa     2640

aatgctttag tggatacatc aggatataat gcagaagtga ggctagaagg tgatgttcaa     2700

gttaatacga tatatacaaa tgattttaaa ttaagtagtt caggagataa aattatagta     2760

aatttaaata ataatatttt atatagcgct atttatgaga actctagtgt tagtttttgg     2820

attaagatat ctaaagattt aactaattct cataatgaat atacaataat taatagtata     2880

aaacaaaatt ctgggtggaa attatgtatt aggaatggca atatagaatg gattttacaa     2940

gatattaata gaaagtataa aagtttaatt tttgattata gtgaatcatt aagtcataca     3000

ggatatacaa ataaatggtt ttttgttact ataactaata atataatggg gtatatgaaa     3060

ctttatataa atggagaatt aaagcagagt gaaagaattg aagatttaaa tgaggttaag     3120

ttagataaaa ccatagtatt tggaatagat gagaatatag atgagaatca gatgctttgg     3180

attagagatt ttaatatttt ttctaaagaa ttaagcaatg aagatattaa tattgtatat     3240

gagggacaaa tattaagaaa tgttattaaa gattattggg gaaatccttt gaagtttgat     3300

acagaatatt atattattaa tgataattat atagataggt atatagcacc taaaagtaat     3360

atacttgtac ttgttcagta tccagataga tctaaattat atactggaaa tcctattact     3420

attaaatcag tatctgataa gaatccttat agtagaattt taaatggaga taatataatg     3480

tttcatatgt tatataatag tgggaaatat atgataataa gagatactga tacaatatat     3540

gcaatagaag gaagagagtg ttcaaaaaat tgtgtatatg cattaaaatt acagagtaat     3600

ttaggtaatt atggtatagg tatatttagt ataaaaaata ttgtatctca aaataaatat     3660

tgtagtcaaa ttttctctag ttttatgaaa aatacaatgc ttctagcaga tatatataaa     3720

ccttggagat tttcttttga aaatgcatac acgccagttg cagtaactaa ttatgagaca     3780

aaactattat caacttcatc tttttggaaa tttatttcta gggatccagg atgggtagag     3840

taa                                                                   3843


<210>  6
<211>  3617
<212>  PRT
<213>  Clostridium botulinum

<400>  6

Met Glu Thr Pro Arg Ile Leu Glu Thr His Arg Ile Leu Glu Ala Ser 
1               5                   10                  15      


Asn Ala Ser Asn Pro His Glu Ala Ser Asn Thr Tyr Arg Ser Glu Arg 
            20                  25                  30          


Ala Ser Pro Pro Arg Val Ala Leu Ala Ser Pro Ala Ser Asn Leu Tyr 
        35                  40                  45              


Ser Ala Ser Asn Ile Leu Glu Leu Glu Thr Tyr Arg Leu Glu Ala Ser 
    50                  55                  60                  


Pro Thr His Arg His Ile Ser Leu Glu Ala Ser Asn Thr His Arg Leu 
65                  70                  75                  80  


Glu Ala Leu Ala Ala Ser Asn Gly Leu Pro Arg Gly Leu Leu Tyr Ser 
                85                  90                  95      


Ala Leu Ala Pro His Glu Ala Arg Gly Ile Leu Glu Ile Leu Glu Gly 
            100                 105                 110         


Leu Tyr Ala Ser Asn Ile Leu Glu Thr Arg Pro Val Ala Leu Ile Leu 
        115                 120                 125             


Glu Pro Arg Ala Ser Pro Ala Arg Gly Pro His Glu Ser Glu Arg Ala 
    130                 135                 140                 


Arg Gly Ala Ser Pro Ser Glu Arg Ala Ser Asn Pro Arg Ala Ser Asn 
145                 150                 155                 160 


Leu Glu Ala Ser Asn Leu Tyr Ser Pro Arg Pro Arg Ala Arg Gly Val 
                165                 170                 175     


Ala Leu Thr His Arg Ser Glu Arg Pro Arg Leu Tyr Ser Ser Glu Arg 
            180                 185                 190         


Gly Leu Tyr Thr Tyr Arg Thr Tyr Arg Ala Ser Pro Pro Arg Ala Ser 
        195                 200                 205             


Asn Thr Tyr Arg Leu Glu Ser Glu Arg Thr His Arg Ala Ser Pro Ser 
    210                 215                 220                 


Glu Arg Gly Leu Leu Tyr Ser Ala Ser Pro Thr His Arg Pro His Glu 
225                 230                 235                 240 


Leu Glu Leu Tyr Ser Gly Leu Ile Leu Glu Ile Leu Glu Leu Tyr Ser 
                245                 250                 255     


Leu Glu Pro His Glu Leu Tyr Ser Ala Arg Gly Ile Leu Glu Ala Ser 
            260                 265                 270         


Asn Ser Glu Arg Ala Arg Gly Gly Leu Ile Leu Glu Gly Leu Tyr Gly 
        275                 280                 285             


Leu Gly Leu Leu Glu Ile Leu Glu Thr Tyr Arg Ala Arg Gly Leu Glu 
    290                 295                 300                 


Ala Leu Ala Thr His Arg Ala Ser Pro Ile Leu Glu Pro Arg Pro His 
305                 310                 315                 320 


Glu Pro Arg Gly Leu Tyr Ala Ser Asn Ala Ser Asn Ala Ser Asn Thr 
                325                 330                 335     


His Arg Pro Arg Ile Leu Glu Ala Ser Asn Thr His Arg Pro His Glu 
            340                 345                 350         


Ala Ser Pro Pro His Glu Ala Ser Pro Val Ala Leu Ala Ser Pro Pro 
        355                 360                 365             


His Glu Ala Ser Asn Ser Glu Arg Val Ala Leu Ala Ser Pro Val Ala 
    370                 375                 380                 


Leu Leu Tyr Ser Thr His Arg Ala Arg Gly Gly Leu Asn Gly Leu Tyr 
385                 390                 395                 400 


Ala Ser Asn Ala Ser Asn Thr Arg Pro Val Ala Leu Leu Tyr Ser Thr 
                405                 410                 415     


His Arg Gly Leu Tyr Ser Glu Arg Ile Leu Glu Ala Ser Asn Pro Arg 
            420                 425                 430         


Ser Glu Arg Val Ala Leu Ile Leu Glu Ile Leu Glu Thr His Arg Gly 
        435                 440                 445             


Leu Tyr Pro Arg Ala Arg Gly Gly Leu Ala Ser Asn Ile Leu Glu Ile 
    450                 455                 460                 


Leu Glu Ala Ser Pro Pro Arg Gly Leu Thr His Arg Ser Glu Arg Thr 
465                 470                 475                 480 


His Arg Pro His Glu Leu Tyr Ser Leu Glu Thr His Arg Ala Ser Asn 
                485                 490                 495     


Ala Ser Asn Thr His Arg Pro His Glu Ala Leu Ala Ala Leu Ala Gly 
            500                 505                 510         


Leu Asn Gly Leu Gly Leu Tyr Pro His Glu Gly Leu Tyr Ala Leu Ala 
        515                 520                 525             


Leu Glu Ser Glu Arg Ile Leu Glu Ile Leu Glu Ser Glu Arg Ile Leu 
    530                 535                 540                 


Glu Ser Glu Arg Pro Arg Ala Arg Gly Pro His Glu Met Glu Thr Leu 
545                 550                 555                 560 


Glu Thr His Arg Thr Tyr Arg Ser Glu Arg Ala Ser Asn Ala Leu Ala 
                565                 570                 575     


Thr His Arg Ala Ser Asn Ala Ser Asn Val Ala Leu Gly Leu Tyr Gly 
            580                 585                 590         


Leu Gly Leu Tyr Ala Arg Gly Pro His Glu Ser Glu Arg Leu Tyr Ser 
        595                 600                 605             


Ser Glu Arg Gly Leu Pro His Glu Cys Tyr Ser Met Glu Thr Ala Ser 
    610                 615                 620                 


Pro Pro Arg Ile Leu Glu Leu Glu Ile Leu Glu Leu Glu Met Glu Thr 
625                 630                 635                 640 


His Ile Ser Gly Leu Leu Glu Ala Ser Asn His Ile Ser Ala Leu Ala 
                645                 650                 655     


Met Glu Thr His Ile Ser Ala Ser Asn Leu Glu Thr Tyr Arg Gly Leu 
            660                 665                 670         


Tyr Ile Leu Glu Ala Leu Ala Ile Leu Glu Pro Arg Ala Ser Asn Ala 
        675                 680                 685             


Ser Pro Gly Leu Asn Ala Arg Gly Ile Leu Glu Ser Glu Arg Ser Glu 
    690                 695                 700                 


Arg Val Ala Leu Thr His Arg Ser Glu Arg Ala Ser Asn Ile Leu Glu 
705                 710                 715                 720 


Pro His Glu Thr Tyr Arg Ser Glu Arg Gly Leu Asn Thr Tyr Arg Leu 
                725                 730                 735     


Tyr Ser Val Ala Leu Leu Tyr Ser Leu Glu Gly Leu Thr Tyr Arg Ala 
            740                 745                 750         


Leu Ala Gly Leu Ile Leu Glu Thr Tyr Arg Ala Leu Ala Pro His Glu 
        755                 760                 765             


Gly Leu Tyr Gly Leu Tyr Pro Arg Thr His Arg Ile Leu Glu Ala Ser 
    770                 775                 780                 


Pro Leu Glu Ile Leu Glu Pro Arg Leu Tyr Ser Ser Glu Arg Ala Leu 
785                 790                 795                 800 


Ala Ala Arg Gly Leu Tyr Ser Thr Tyr Arg Pro His Glu Gly Leu Gly 
                805                 810                 815     


Leu Leu Tyr Ser Ala Leu Ala Leu Glu Ala Ser Pro Thr Tyr Arg Thr 
            820                 825                 830         


Tyr Arg Ala Arg Gly Ser Glu Arg Ile Leu Glu Ala Leu Ala Leu Tyr 
        835                 840                 845             


Ser Ala Arg Gly Leu Glu Ala Ser Asn Ser Glu Arg Ile Leu Glu Thr 
    850                 855                 860                 


His Arg Thr His Arg Ala Leu Ala Ala Ser Asn Pro Arg Ser Glu Arg 
865                 870                 875                 880 


Ser Glu Arg Pro His Glu Ala Ser Asn Leu Tyr Ser Thr Tyr Arg Ile 
                885                 890                 895     


Leu Glu Gly Leu Tyr Gly Leu Thr Tyr Arg Leu Tyr Ser Gly Leu Asn 
            900                 905                 910         


Leu Tyr Ser Leu Glu Ile Leu Glu Ala Arg Gly Leu Tyr Ser Thr Tyr 
        915                 920                 925             


Arg Ala Arg Gly Pro His Glu Val Ala Leu Val Ala Leu Gly Leu Ser 
    930                 935                 940                 


Glu Arg Ser Glu Arg Gly Leu Tyr Gly Leu Val Ala Leu Ala Leu Ala 
945                 950                 955                 960 


Val Ala Leu Ala Ser Pro Ala Arg Gly Ala Ser Asn Leu Tyr Ser Pro 
                965                 970                 975     


His Glu Ala Leu Ala Gly Leu Leu Glu Thr Tyr Arg Leu Tyr Ser Gly 
            980                 985                 990         


Leu Leu Glu Thr His Arg Gly Leu  Asn Ile Leu Glu Pro  His Glu Thr 
        995                 1000                 1005             


His Arg  Gly Leu Pro His Glu  Ala Ser Asn Thr Tyr  Arg Ala Leu 
    1010                 1015                 1020             


Ala Leu  Tyr Ser Ile Leu Glu  Thr Tyr Arg Ala Ser  Asn Val Ala 
    1025                 1030                 1035             


Leu Gly  Leu Asn Ala Ser Asn  Ala Arg Gly Leu Tyr  Ser Ile Leu 
    1040                 1045                 1050             


Glu Thr  Tyr Arg Leu Glu Ser  Glu Arg Ala Ser Asn  Val Ala Leu 
    1055                 1060                 1065             


Thr Tyr  Arg Thr His Arg Pro  Arg Val Ala Leu Thr  His Arg Ala 
    1070                 1075                 1080             


Leu Ala  Ala Ser Asn Ile Leu  Glu Leu Glu Ala Ser  Pro Ala Ser 
    1085                 1090                 1095             


Pro Ala  Ser Asn Val Ala Leu  Thr Tyr Arg Ala Ser  Pro Ile Leu 
    1100                 1105                 1110             


Glu Gly  Leu Asn Ala Ser Asn  Gly Leu Tyr Pro His  Glu Ala Ser 
    1115                 1120                 1125             


Asn Ile  Leu Glu Pro Arg Leu  Tyr Ser Ser Glu Arg  Ala Ser Asn 
    1130                 1135                 1140             


Leu Glu  Ala Ser Asn Val Ala  Leu Leu Glu Pro His  Glu Met Glu 
    1145                 1150                 1155             


Thr Gly  Leu Tyr Gly Leu Asn  Ala Ser Asn Leu Glu  Ser Glu Arg 
    1160                 1165                 1170             


Ala Arg  Gly Ala Ser Asn Pro  Arg Ala Leu Ala Leu  Glu Ala Arg 
    1175                 1180                 1185             


Gly Leu  Tyr Ser Val Ala Leu  Ala Ser Asn Pro Arg  Gly Leu Ala 
    1190                 1195                 1200             


Ser Asn  Met Glu Thr Leu Glu  Thr Tyr Arg Leu Glu  Pro His Glu 
    1205                 1210                 1215             


Thr His  Arg Leu Tyr Ser Pro  His Glu Cys Tyr Ser  His Ile Ser 
    1220                 1225                 1230             


Leu Tyr  Ser Ala Leu Ala Ile  Leu Glu Ala Ser Pro  Gly Leu Tyr 
    1235                 1240                 1245             


Ala Arg  Gly Ser Glu Arg Leu  Glu Thr Tyr Arg Ala  Ser Asn Leu 
    1250                 1255                 1260             


Tyr Ser  Thr His Arg Leu Glu  Ala Ser Pro Cys Tyr  Ser Ala Arg 
    1265                 1270                 1275             


Gly Gly  Leu Leu Glu Leu Glu  Val Ala Leu Leu Tyr  Ser Ala Ser 
    1280                 1285                 1290             


Asn Thr  His Arg Ala Ser Pro  Leu Glu Pro Arg Pro  His Glu Ile 
    1295                 1300                 1305             


Leu Glu  Gly Leu Tyr Ala Ser  Pro Ile Leu Glu Ser  Glu Arg Ala 
    1310                 1315                 1320             


Ser Pro  Ile Leu Glu Leu Tyr  Ser Thr His Arg Ala  Ser Pro Ile 
    1325                 1330                 1335             


Leu Glu  Pro His Glu Leu Glu  Ser Glu Arg Leu Tyr  Ser Ala Ser 
    1340                 1345                 1350             


Pro Ile  Leu Glu Ala Ser Asn  Gly Leu Gly Leu Thr  His Arg Gly 
    1355                 1360                 1365             


Leu Val  Ala Leu Ile Leu Glu  Ala Ser Pro Thr Tyr  Arg Pro Arg 
    1370                 1375                 1380             


Ala Ser  Pro Ala Ser Asn Val  Ala Leu Ser Glu Arg  Val Ala Leu 
    1385                 1390                 1395             


Ala Ser  Pro Gly Leu Asn Val  Ala Leu Ile Leu Glu  Leu Glu Ser 
    1400                 1405                 1410             


Glu Arg  Leu Tyr Ser Ala Ser  Asn Thr His Arg Ser  Glu Arg Gly 
    1415                 1420                 1425             


Leu His  Ile Ser Gly Leu Tyr  Gly Leu Asn Leu Glu  Ala Ser Pro 
    1430                 1435                 1440             


Leu Glu  Leu Glu Thr Tyr Arg  Pro Arg Ile Leu Glu  Ile Leu Glu 
    1445                 1450                 1455             


Gly Leu  Gly Leu Tyr Gly Leu  Ser Glu Arg Gly Leu  Asn Val Ala 
    1460                 1465                 1470             


Leu Leu  Glu Pro Arg Gly Leu  Tyr Gly Leu Ala Ser  Asn Gly Leu 
    1475                 1480                 1485             


Asn Val  Ala Leu Pro His Glu  Thr Tyr Arg Ala Ser  Pro Ala Ser 
    1490                 1495                 1500             


Asn Ala  Arg Gly Thr His Arg  Gly Leu Asn Ala Ser  Asn Val Ala 
    1505                 1510                 1515             


Leu Ala  Ser Pro Thr Tyr Arg  Leu Glu Ala Ser Asn  Ser Glu Arg 
    1520                 1525                 1530             


Thr Tyr  Arg Thr Tyr Arg Thr  Tyr Arg Leu Glu Gly  Leu Ser Glu 
    1535                 1540                 1545             


Arg Gly  Leu Asn Leu Tyr Ser  Leu Glu Ser Glu Arg  Ala Ser Pro 
    1550                 1555                 1560             


Ala Ser  Asn Val Ala Leu Gly  Leu Ala Ser Pro Pro  His Glu Thr 
    1565                 1570                 1575             


His Arg  Pro His Glu Thr His  Arg Thr His Arg Ser  Glu Arg Ile 
    1580                 1585                 1590             


Leu Glu  Gly Leu Gly Leu Ala  Leu Ala Leu Glu Ala  Ser Pro Ala 
    1595                 1600                 1605             


Ser Asn  Ser Glu Arg Gly Leu  Tyr Leu Tyr Ser Val  Ala Leu Thr 
    1610                 1615                 1620             


Tyr Arg  Thr His Arg Thr Tyr  Arg Pro His Glu Pro  Arg Leu Tyr 
    1625                 1630                 1635             


Ser Leu  Glu Ala Leu Ala Ala  Ser Pro Leu Tyr Ser  Val Ala Leu 
    1640                 1645                 1650             


Ala Ser  Asn Thr His Arg Gly  Leu Tyr Val Ala Leu  Gly Leu Asn 
    1655                 1660                 1665             


Gly Leu  Tyr Gly Leu Tyr Leu  Glu Pro His Glu Leu  Glu Met Glu 
    1670                 1675                 1680             


Thr Thr  Arg Pro Ala Leu Ala  Ala Ser Asn Ala Ser  Pro Val Ala 
    1685                 1690                 1695             


Leu Val  Ala Leu Gly Leu Ala  Ser Pro Pro His Glu  Thr His Arg 
    1700                 1705                 1710             


Thr His  Arg Ala Ser Asn Ile  Leu Glu Leu Glu Ala  Arg Gly Leu 
    1715                 1720                 1725             


Tyr Ser  Ala Ser Pro Thr His  Arg Leu Glu Ala Ser  Pro Leu Tyr 
    1730                 1735                 1740             


Ser Ile  Leu Glu Ser Glu Arg  Ala Ser Pro Val Ala  Leu Ser Glu 
    1745                 1750                 1755             


Arg Ala  Leu Ala Ile Leu Glu  Ile Leu Glu Pro Arg  Thr Tyr Arg 
    1760                 1765                 1770             


Ile Leu  Glu Gly Leu Tyr Pro  Arg Ala Leu Ala Leu  Glu Ala Ser 
    1775                 1780                 1785             


Asn Ile  Leu Glu Ser Glu Arg  Ala Ser Asn Ser Glu  Arg Val Ala 
    1790                 1795                 1800             


Leu Ala  Arg Gly Ala Arg Gly  Gly Leu Tyr Ala Ser  Asn Pro His 
    1805                 1810                 1815             


Glu Thr  His Arg Gly Leu Ala  Leu Ala Pro His Glu  Ala Leu Ala 
    1820                 1825                 1830             


Val Ala  Leu Thr His Arg Gly  Leu Tyr Val Ala Leu  Thr His Arg 
    1835                 1840                 1845             


Ile Leu  Glu Leu Glu Leu Glu  Gly Leu Ala Leu Ala  Pro His Glu 
    1850                 1855                 1860             


Gly Leu  Asn Gly Leu Pro His  Glu Thr His Arg Ile  Leu Glu Pro 
    1865                 1870                 1875             


Arg Ala  Leu Ala Leu Glu Gly  Leu Tyr Ala Leu Ala  Pro His Glu 
    1880                 1885                 1890             


Val Ala  Leu Ile Leu Glu Thr  Tyr Arg Ser Glu Arg  Leu Tyr Ser 
    1895                 1900                 1905             


Val Ala  Leu Gly Leu Asn Gly  Leu Ala Arg Gly Ala  Ser Asn Gly 
    1910                 1915                 1920             


Leu Ile  Leu Glu Ile Leu Glu  Leu Tyr Ser Thr His  Arg Ile Leu 
    1925                 1930                 1935             


Glu Ala  Ser Pro Ala Ser Asn  Cys Tyr Ser Leu Glu  Gly Leu Gly 
    1940                 1945                 1950             


Leu Asn  Ala Arg Gly Ile Leu  Glu Leu Tyr Ser Ala  Arg Gly Thr 
    1955                 1960                 1965             


Arg Pro  Leu Tyr Ser Ala Ser  Pro Ser Glu Arg Thr  Tyr Arg Gly 
    1970                 1975                 1980             


Leu Thr  Arg Pro Met Glu Thr  Ile Leu Glu Gly Leu  Tyr Thr His 
    1985                 1990                 1995             


Arg Thr  Arg Pro Leu Glu Ser  Glu Arg Ala Arg Gly  Ile Leu Glu 
    2000                 2005                 2010             


Thr His  Arg Thr His Arg Gly  Leu Asn Pro His Glu  Ala Ser Asn 
    2015                 2020                 2025             


Ala Ser  Asn Ile Leu Glu Ser  Glu Arg Thr Tyr Arg  Gly Leu Asn 
    2030                 2035                 2040             


Met Glu  Thr Thr Tyr Arg Ala  Ser Pro Ser Glu Arg  Leu Glu Ala 
    2045                 2050                 2055             


Ser Asn  Thr Tyr Arg Gly Leu  Asn Ala Leu Ala Ala  Ser Pro Ala 
    2060                 2065                 2070             


Leu Ala  Ile Leu Glu Leu Tyr  Ser Ala Ser Pro Leu  Tyr Ser Ile 
    2075                 2080                 2085             


Leu Glu  Ala Ser Pro Leu Glu  Gly Leu Thr Tyr Arg  Leu Tyr Ser 
    2090                 2095                 2100             


Leu Tyr  Ser Thr Tyr Arg Ser  Glu Arg Gly Leu Tyr  Ser Glu Arg 
    2105                 2110                 2115             


Ala Ser  Pro Leu Tyr Ser Gly  Leu Ala Ser Asn Ile  Leu Glu Leu 
    2120                 2125                 2130             


Tyr Ser  Ser Glu Arg Gly Leu  Asn Val Ala Leu Gly  Leu Ala Ser 
    2135                 2140                 2145             


Asn Leu  Glu Leu Tyr Ser Ala  Ser Asn Ser Glu Arg  Leu Glu Ala 
    2150                 2155                 2160             


Ser Pro  Ile Leu Glu Leu Tyr  Ser Ile Leu Glu Ser  Glu Arg Gly 
    2165                 2170                 2175             


Leu Ala  Leu Ala Met Glu Thr  Ala Ser Asn Ala Ser  Asn Ile Leu 
    2180                 2185                 2190             


Glu Ala  Ser Asn Leu Tyr Ser  Pro His Glu Ile Leu  Glu Ala Arg 
    2195                 2200                 2205             


Gly Gly  Leu Cys Tyr Ser Ser  Glu Arg Val Ala Leu  Thr His Arg 
    2210                 2215                 2220             


Thr Tyr  Arg Leu Glu Pro His  Glu Leu Tyr Ser Ala  Ser Asn Met 
    2225                 2230                 2235             


Glu Thr  Leu Glu Pro Arg Leu  Tyr Ser Val Ala Leu  Ile Leu Glu 
    2240                 2245                 2250             


Ala Ser  Pro Gly Leu Leu Glu  Ala Ser Asn Leu Tyr  Ser Pro His 
    2255                 2260                 2265             


Glu Ala  Ser Pro Leu Glu Leu  Tyr Ser Thr His Arg  Leu Tyr Ser 
    2270                 2275                 2280             


Thr His  Arg Gly Leu Leu Glu  Ile Leu Glu Ala Ser  Asn Leu Glu 
    2285                 2290                 2295             


Ile Leu  Glu Ala Ser Pro Ser  Glu Arg His Ile Ser  Ala Ser Asn 
    2300                 2305                 2310             


Ile Leu  Glu Ile Leu Glu Leu  Glu Val Ala Leu Gly  Leu Tyr Gly 
    2315                 2320                 2325             


Leu Val  Ala Leu Ala Ser Pro  Ala Arg Gly Leu Glu  Leu Tyr Ser 
    2330                 2335                 2340             


Ala Leu  Ala Leu Tyr Ser Val  Ala Leu Ala Ser Asn  Gly Leu Ser 
    2345                 2350                 2355             


Glu Arg  Pro His Glu Gly Leu  Ala Ser Asn Thr His  Arg Ile Leu 
    2360                 2365                 2370             


Glu Pro  Arg Pro His Glu Ala  Ser Asn Ile Leu Glu  Pro His Glu 
    2375                 2380                 2385             


Ser Glu  Arg Thr Tyr Arg Thr  His Arg Ala Ser Asn  Ala Ser Asn 
    2390                 2395                 2400             


Ser Glu  Arg Leu Glu Leu Glu  Leu Tyr Ser Ala Ser  Pro Ile Leu 
    2405                 2410                 2415             


Glu Ile  Leu Glu Ala Ser Asn  Gly Leu Thr Tyr Arg  Pro His Glu 
    2420                 2425                 2430             


Ala Ser  Asn Ser Glu Arg Ile  Leu Glu Ala Ser Asn  Ala Ser Pro 
    2435                 2440                 2445             


Ser Glu  Arg Leu Tyr Ser Ile  Leu Glu Leu Glu Ser  Glu Arg Leu 
    2450                 2455                 2460             


Glu Gly  Leu Asn Ala Ser Asn  Leu Tyr Ser Leu Tyr  Ser Ala Ser 
    2465                 2470                 2475             


Asn Ala  Leu Ala Leu Glu Val  Ala Leu Ala Ser Pro  Thr His Arg 
    2480                 2485                 2490             


Ser Glu  Arg Gly Leu Tyr Thr  Tyr Arg Ala Ser Asn  Ala Leu Ala 
    2495                 2500                 2505             


Gly Leu  Val Ala Leu Ala Arg  Gly Leu Glu Gly Leu  Gly Leu Tyr 
    2510                 2515                 2520             


Ala Ser  Pro Val Ala Leu Gly  Leu Asn Val Ala Leu  Ala Ser Asn 
    2525                 2530                 2535             


Thr His  Arg Ile Leu Glu Thr  Tyr Arg Thr His Arg  Ala Ser Asn 
    2540                 2545                 2550             


Ala Ser  Pro Pro His Glu Leu  Tyr Ser Leu Glu Ser  Glu Arg Ser 
    2555                 2560                 2565             


Glu Arg  Ser Glu Arg Gly Leu  Tyr Ala Ser Pro Leu  Tyr Ser Ile 
    2570                 2575                 2580             


Leu Glu  Ile Leu Glu Val Ala  Leu Ala Ser Asn Leu  Glu Ala Ser 
    2585                 2590                 2595             


Asn Ala  Ser Asn Ala Ser Asn  Ile Leu Glu Leu Glu  Thr Tyr Arg 
    2600                 2605                 2610             


Ser Glu  Arg Ala Leu Ala Ile  Leu Glu Thr Tyr Arg  Gly Leu Ala 
    2615                 2620                 2625             


Ser Asn  Ser Glu Arg Ser Glu  Arg Val Ala Leu Ser  Glu Arg Pro 
    2630                 2635                 2640             


His Glu  Thr Arg Pro Ile Leu  Glu Leu Tyr Ser Ile  Leu Glu Ser 
    2645                 2650                 2655             


Glu Arg  Leu Tyr Ser Ala Ser  Pro Leu Glu Thr His  Arg Ala Ser 
    2660                 2665                 2670             


Asn Ser  Glu Arg His Ile Ser  Ala Ser Asn Gly Leu  Thr Tyr Arg 
    2675                 2680                 2685             


Thr His  Arg Ile Leu Glu Ile  Leu Glu Ala Ser Asn  Ser Glu Arg 
    2690                 2695                 2700             


Ile Leu  Glu Leu Tyr Ser Gly  Leu Asn Ala Ser Asn  Ser Glu Arg 
    2705                 2710                 2715             


Gly Leu  Tyr Thr Arg Pro Leu  Tyr Ser Leu Glu Cys  Tyr Ser Ile 
    2720                 2725                 2730             


Leu Glu  Ala Arg Gly Ala Ser  Asn Gly Leu Tyr Ala  Ser Asn Ile 
    2735                 2740                 2745             


Leu Glu  Gly Leu Thr Arg Pro  Ile Leu Glu Leu Glu  Gly Leu Asn 
    2750                 2755                 2760             


Ala Ser  Pro Ile Leu Glu Ala  Ser Asn Ala Arg Gly  Leu Tyr Ser 
    2765                 2770                 2775             


Thr Tyr  Arg Leu Tyr Ser Ser  Glu Arg Leu Glu Ile  Leu Glu Pro 
    2780                 2785                 2790             


His Glu  Ala Ser Pro Thr Tyr  Arg Ser Glu Arg Gly  Leu Ser Glu 
    2795                 2800                 2805             


Arg Leu  Glu Ser Glu Arg His  Ile Ser Thr His Arg  Gly Leu Tyr 
    2810                 2815                 2820             


Thr Tyr  Arg Thr His Arg Ala  Ser Asn Leu Tyr Ser  Thr Arg Pro 
    2825                 2830                 2835             


Pro His  Glu Pro His Glu Val  Ala Leu Thr His Arg  Ile Leu Glu 
    2840                 2845                 2850             


Thr His  Arg Ala Ser Asn Ala  Ser Asn Ile Leu Glu  Met Glu Thr 
    2855                 2860                 2865             


Gly Leu  Tyr Thr Tyr Arg Met  Glu Thr Leu Tyr Ser  Leu Glu Thr 
    2870                 2875                 2880             


Tyr Arg  Ile Leu Glu Ala Ser  Asn Gly Leu Tyr Gly  Leu Leu Glu 
    2885                 2890                 2895             


Leu Tyr  Ser Gly Leu Asn Ser  Glu Arg Gly Leu Ala  Arg Gly Ile 
    2900                 2905                 2910             


Leu Glu  Gly Leu Ala Ser Pro  Leu Glu Ala Ser Asn  Gly Leu Val 
    2915                 2920                 2925             


Ala Leu  Leu Tyr Ser Leu Glu  Ala Ser Pro Leu Tyr  Ser Thr His 
    2930                 2935                 2940             


Arg Ile  Leu Glu Val Ala Leu  Pro His Glu Gly Leu  Tyr Ile Leu 
    2945                 2950                 2955             


Glu Ala  Ser Pro Gly Leu Ala  Ser Asn Ile Leu Glu  Ala Ser Pro 
    2960                 2965                 2970             


Gly Leu  Ala Ser Asn Gly Leu  Asn Met Glu Thr Leu  Glu Thr Arg 
    2975                 2980                 2985             


Pro Ile  Leu Glu Ala Arg Gly  Ala Ser Pro Pro His  Glu Ala Ser 
    2990                 2995                 3000             


Asn Ile  Leu Glu Pro His Glu  Ser Glu Arg Leu Tyr  Ser Gly Leu 
    3005                 3010                 3015             


Leu Glu  Ser Glu Arg Ala Ser  Asn Gly Leu Ala Ser  Pro Ile Leu 
    3020                 3025                 3030             


Glu Ala  Ser Asn Ile Leu Glu  Val Ala Leu Thr Tyr  Arg Gly Leu 
    3035                 3040                 3045             


Gly Leu  Tyr Gly Leu Asn Ile  Leu Glu Leu Glu Ala  Arg Gly Ala 
    3050                 3055                 3060             


Ser Asn  Val Ala Leu Ile Leu  Glu Leu Tyr Ser Ala  Ser Pro Thr 
    3065                 3070                 3075             


Tyr Arg  Thr Arg Pro Gly Leu  Tyr Ala Ser Asn Pro  Arg Leu Glu 
    3080                 3085                 3090             


Leu Tyr  Ser Pro His Glu Ala  Ser Pro Thr His Arg  Gly Leu Thr 
    3095                 3100                 3105             


Tyr Arg  Thr Tyr Arg Ile Leu  Glu Ile Leu Glu Ala  Ser Asn Ala 
    3110                 3115                 3120             


Ser Pro  Ala Ser Asn Thr Tyr  Arg Ile Leu Glu Ala  Ser Pro Ala 
    3125                 3130                 3135             


Arg Gly  Thr Tyr Arg Ile Leu  Glu Ala Leu Ala Pro  Arg Leu Tyr 
    3140                 3145                 3150             


Ser Ser  Glu Arg Ala Ser Asn  Ile Leu Glu Leu Glu  Val Ala Leu 
    3155                 3160                 3165             


Leu Glu  Val Ala Leu Gly Leu  Asn Thr Tyr Arg Pro  Arg Ala Ser 
    3170                 3175                 3180             


Pro Ala  Arg Gly Ser Glu Arg  Leu Tyr Ser Leu Glu  Thr Tyr Arg 
    3185                 3190                 3195             


Thr His  Arg Gly Leu Tyr Ala  Ser Asn Pro Arg Ile  Leu Glu Thr 
    3200                 3205                 3210             


His Arg  Ile Leu Glu Leu Tyr  Ser Ser Glu Arg Val  Ala Leu Ser 
    3215                 3220                 3225             


Glu Arg  Ala Ser Pro Leu Tyr  Ser Ala Ser Asn Pro  Arg Thr Tyr 
    3230                 3235                 3240             


Arg Ser  Glu Arg Ala Arg Gly  Ile Leu Glu Leu Glu  Ala Ser Asn 
    3245                 3250                 3255             


Gly Leu  Tyr Ala Ser Pro Ala  Ser Asn Ile Leu Glu  Met Glu Thr 
    3260                 3265                 3270             


Pro His  Glu His Ile Ser Met  Glu Thr Leu Glu Thr  Tyr Arg Ala 
    3275                 3280                 3285             


Ser Asn  Ser Glu Arg Gly Leu  Tyr Leu Tyr Ser Thr  Tyr Arg Met 
    3290                 3295                 3300             


Glu Thr  Ile Leu Glu Ile Leu  Glu Ala Arg Gly Ala  Ser Pro Thr 
    3305                 3310                 3315             


His Arg  Ala Ser Pro Thr His  Arg Ile Leu Glu Thr  Tyr Arg Ala 
    3320                 3325                 3330             


Leu Ala  Ile Leu Glu Gly Leu  Gly Leu Tyr Ala Arg  Gly Gly Leu 
    3335                 3340                 3345             


Cys Tyr  Ser Ser Glu Arg Leu  Tyr Ser Ala Ser Asn  Cys Tyr Ser 
    3350                 3355                 3360             


Val Ala  Leu Thr Tyr Arg Ala  Leu Ala Leu Glu Leu  Tyr Ser Leu 
    3365                 3370                 3375             


Glu Gly  Leu Asn Ser Glu Arg  Ala Ser Asn Leu Glu  Gly Leu Tyr 
    3380                 3385                 3390             


Ala Ser  Asn Thr Tyr Arg Gly  Leu Tyr Ile Leu Glu  Gly Leu Tyr 
    3395                 3400                 3405             


Ile Leu  Glu Pro His Glu Ser  Glu Arg Ile Leu Glu  Leu Tyr Ser 
    3410                 3415                 3420             


Ala Ser  Asn Ile Leu Glu Val  Ala Leu Ser Glu Arg  Gly Leu Asn 
    3425                 3430                 3435             


Ala Ser  Asn Leu Tyr Ser Thr  Tyr Arg Cys Tyr Ser  Ser Glu Arg 
    3440                 3445                 3450             


Gly Leu  Asn Ile Leu Glu Pro  His Glu Ser Glu Arg  Ser Glu Arg 
    3455                 3460                 3465             


Pro His  Glu Met Glu Thr Leu  Tyr Ser Ala Ser Asn  Thr His Arg 
    3470                 3475                 3480             


Met Glu  Thr Leu Glu Leu Glu  Ala Leu Ala Ala Ser  Pro Ile Leu 
    3485                 3490                 3495             


Glu Thr  Tyr Arg Leu Tyr Ser  Pro Arg Thr Arg Pro  Ala Arg Gly 
    3500                 3505                 3510             


Pro His  Glu Ser Glu Arg Pro  His Glu Gly Leu Ala  Ser Asn Ala 
    3515                 3520                 3525             


Leu Ala  Thr Tyr Arg Thr His  Arg Pro Arg Val Ala  Leu Ala Leu 
    3530                 3535                 3540             


Ala Val  Ala Leu Thr His Arg  Ala Ser Asn Thr Tyr  Arg Gly Leu 
    3545                 3550                 3555             


Thr His  Arg Leu Tyr Ser Leu  Glu Leu Glu Ser Glu  Arg Thr His 
    3560                 3565                 3570             


Arg Ser  Glu Arg Ser Glu Arg  Pro His Glu Thr Arg  Pro Leu Tyr 
    3575                 3580                 3585             


Ser Pro  His Glu Ile Leu Glu  Ser Glu Arg Ala Arg  Gly Ala Ser 
    3590                 3595                 3600             


Pro Pro  Arg Gly Leu Tyr Thr  Arg Pro Val Ala Leu  Gly Leu 
    3605                 3610                 3615         


<210>  7
<211>  3858
<212>  DNA
<213>  Clostridium botulinum

<400>  7
atgacatggc cagtaaaaga ttttaattat agtgatcctg ttaatgacaa tgatatatta       60

tatttaagaa taccacaaaa taagttaatt actacacctg taaaagcttt tatgattact      120

caaaatattt gggtaatacc agaaagattt tcatcagata ctaatccaag tttaagtaaa      180

ccgcctagac ctacttcaaa gtatcaaagt tattatgatc ctagttattt atctactgat      240

gagcaaaaag atacattttt aaaagggatt ataaaattat ttaaaagaat taatgaaaga      300

gatataggaa aaaaattaat aaattattta gtagttggtt caccttttat gggagattca      360

agtacgcctg aagatacatt tgattttaca cgtcatacta ctaatattgc agttgaaaag      420

tttgaaaatg gtagttggaa agtaacaaat attataacac caagtgtatt gatatttgga      480

ccacttccta atatattaga ctatacagca tcccttacat tgcaaggaca acaatcaaat      540

ccatcatttg aagggtttgg aacattatct atactaaaag tagcacctga atttttgtta      600

acatttagtg atgtaacatc taatcaaagt tcagctgtat taggcaaatc tatattttgt      660

atggatccag taatagcttt aatgcatgag ttaacacatt ctttgcatca attgtatgga      720

ataaatatac catctgataa aaggattcgt ccacaagtta gcgagggatt tttttctcaa      780

gatggaccca acgtacaatt tgaggaatta tacacatttg gaggatcaga tgttgaaata      840

atacctcaaa ttgaaagatt acaattaaga gaaaaagcat taggtcacta taaagatata      900

gcgaaaagac ttaataatat taataaaact attccttcta gttggagtag taatatagat      960

aaatataaaa aaatattttc tgaaaagtat aattttgata aagataatac aggaaatttt     1020

gttgtaaata ttgataaatt caatagctta tattcagact tgactaatgt tatgtcagaa     1080

gttgtttatt cttcgcaata taatgttaaa aacaggactc attatttttc aaagcattat     1140

ctacctgtat ttgcaaatat attagatgat aatatttata ctataataaa cggttttaat     1200

ttaacaacta aaggttttaa tatagaaaat tcgggtcaga atatagaaag gaatcctgca     1260

ctacaaaaac ttagttcaga aagtgtagta gatttgttta caaaagtatg tttaagatta     1320

acaagaaata gtagagatga ttcaacatgt attcaagtta aaaataatac attaccttat     1380

gtagctgata aagatagcat ttcacaagaa atatttgaaa gtcaaattat tacagatgag     1440

actaatgtag aaaattattc agataatttt tcattagatg aatctatttt agatgcaaaa     1500

gtccctacta atcctgaagc agtagatcca ctgttaccca atgttaatat ggaaccttta     1560

aatgttccag gtgaagaaga agtattttat gatgatatta ctaaagatgt tgattattta     1620

aactcttatt attatttgga agcccaaaaa ttaagtaata atgttgaaaa tattactctt     1680

acaacttcag ttgaagaagc attaggttat agcaataaga tatacacatt tttacctagc     1740

ttagctgaaa aagtgaataa aggtgttcaa gcaggtttat tcttaaattg ggcgaatgaa     1800

gtagttgagg attttactac aaatattatg aaaaaagata cattggataa aatatcagat     1860

gtatcagcca taattccata tataggacct gccttaaata taggaaattc agcattaagg     1920

ggaaacttta agcaagcatt tgcaacagct ggtgtagctt ttttgttaga aggatttcca     1980

gagtttacaa tacctgcact cggtgtattt accttttata gttctattca agaaagagag     2040

aaaattatta aaactataga aaattgttta gaacaaagag ttaagagatg gaaagattca     2100

tatcaatgga tggtatcaaa ttggttgtca agaattacta ctcgatttaa tcatataagt     2160

tatcaaatgt atgattcttt gagttatcag gcagatgcaa tcaaagctaa aatagattta     2220

gaatataaaa aatactcagg aagtgataaa gaaaatataa aaagtcaagt tgaaaattta     2280

aaaaatagtt tagatgtaaa aatctcggaa gcaatgaata atataaataa atttatacga     2340

gaatgttctg taacatactt atttaaaaat atgctcccta aagtaattga tgaattaaat     2400

aagtttgatt taaaaactaa aacagaatta attaatctta tagatagtca taatattatt     2460

ctagttggtg aagtagatag attaaaagca aaagtaaatg agagttttga aaatacaata     2520

ccctttaata ttttttcata tactaataat tctttattaa aagatatgat taatgaatat     2580

ttcaatagta ttaatgattc aaaaattttg agcttacaaa ataaaaaaaa tactttgatg     2640

gatacatcag gatataacgc agaagtgaga gtagaaggca atgttcagct taatccaata     2700

tttccatttg actttaaatt aggtagttca ggggatgata gaggtaaagt tatagtaacc     2760

cagaatgaaa atattgtata taatgctatg tatgaaagtt ttagtattag tttttggatt     2820

aggataaata aatgggtaag taatttacct ggatatacta taattgatag tgttaaaaat     2880

aactcaggtt ggagtatagg tattattagt aattttttag tgtttacttt aaaacaaaat     2940

gaaaatagtg aacaagatat aaactttagt tatgatatat caaagaatgc tgcgggatat     3000

aataaatggt tttttgtaac tattactacc aatatgatgg gaaatatgat gatttatata     3060

aatggaaaat taatagatac tataaaagtt aaagagttaa ctggaattaa ttttagcaaa     3120

actataacat ttcaaatgaa taaaattcca aatactggct taattacctc agattctgat     3180

aacatcaata tgtggataag ggatttttat atctttgcta aagaattaga tgataaagat     3240

attaatatat tatttaatag cttgcaatat actaatgttg taaaagatta ttggggaaat     3300

gatttaagat atgataaaga atattacatg attaacgtaa attatatgaa tagatatatg     3360

tctaaaaaag gcaatggaat tgtttttaat acacgtaaaa ataataatga cttcaatgaa     3420

ggatataaaa ttataataaa aagaattaga ggaaatacaa atgatactag agtacgagga     3480

gaaaatgtat tatattttaa tactacaatt gataacaaac aatatagttt aggtatgtat     3540

aaaccttcta gaaatctagg gactgattta gttccactag gtgcattgga tcaaccaatg     3600

gatgagatac gtaaatatgg ttcgtttata atacaaccat gcaatacttt tgattactat     3660

gcatcacaat tatttttgtc aagtaatgca acaacaaata ggcttggaat actatcaatt     3720

ggtagttata gtttcaaact tggagatgac tattggttta atcacgaata tttaattcct     3780

gttataaaaa tagagcatta tgcttcatta ttagaatcaa catcaactca ttgggttttt     3840

gtacctgcaa gtgaataa                                                   3858


<210>  8
<211>  3632
<212>  PRT
<213>  Clostridium botulinum

<400>  8

Met Glu Thr Thr His Arg Thr Arg Pro Pro Arg Val Ala Leu Leu Tyr 
1               5                   10                  15      


Ser Ala Ser Pro Pro His Glu Ala Ser Asn Thr Tyr Arg Ser Glu Arg 
            20                  25                  30          


Ala Ser Pro Pro Arg Val Ala Leu Ala Ser Asn Ala Ser Pro Ala Ser 
        35                  40                  45              


Asn Ala Ser Pro Ile Leu Glu Leu Glu Thr Tyr Arg Leu Glu Ala Arg 
    50                  55                  60                  


Gly Ile Leu Glu Pro Arg Gly Leu Asn Ala Ser Asn Leu Tyr Ser Leu 
65                  70                  75                  80  


Glu Ile Leu Glu Thr His Arg Thr His Arg Pro Arg Val Ala Leu Leu 
                85                  90                  95      


Tyr Ser Ala Leu Ala Pro His Glu Met Glu Thr Ile Leu Glu Thr His 
            100                 105                 110         


Arg Gly Leu Asn Ala Ser Asn Ile Leu Glu Thr Arg Pro Val Ala Leu 
        115                 120                 125             


Ile Leu Glu Pro Arg Gly Leu Ala Arg Gly Pro His Glu Ser Glu Arg 
    130                 135                 140                 


Ser Glu Arg Ala Ser Pro Thr His Arg Ala Ser Asn Pro Arg Ser Glu 
145                 150                 155                 160 


Arg Leu Glu Ser Glu Arg Leu Tyr Ser Pro Arg Pro Arg Ala Arg Gly 
                165                 170                 175     


Pro Arg Thr His Arg Ser Glu Arg Leu Tyr Ser Thr Tyr Arg Gly Leu 
            180                 185                 190         


Asn Ser Glu Arg Thr Tyr Arg Thr Tyr Arg Ala Ser Pro Pro Arg Ser 
        195                 200                 205             


Glu Arg Thr Tyr Arg Leu Glu Ser Glu Arg Thr His Arg Ala Ser Pro 
    210                 215                 220                 


Gly Leu Gly Leu Asn Leu Tyr Ser Ala Ser Pro Thr His Arg Pro His 
225                 230                 235                 240 


Glu Leu Glu Leu Tyr Ser Gly Leu Tyr Ile Leu Glu Ile Leu Glu Leu 
                245                 250                 255     


Tyr Ser Leu Glu Pro His Glu Leu Tyr Ser Ala Arg Gly Ile Leu Glu 
            260                 265                 270         


Ala Ser Asn Gly Leu Ala Arg Gly Ala Ser Pro Ile Leu Glu Gly Leu 
        275                 280                 285             


Tyr Leu Tyr Ser Leu Tyr Ser Leu Glu Ile Leu Glu Ala Ser Asn Thr 
    290                 295                 300                 


Tyr Arg Leu Glu Val Ala Leu Val Ala Leu Gly Leu Tyr Ser Glu Arg 
305                 310                 315                 320 


Pro Arg Pro His Glu Met Glu Thr Gly Leu Tyr Ala Ser Pro Ser Glu 
                325                 330                 335     


Arg Ser Glu Arg Thr His Arg Pro Arg Gly Leu Ala Ser Pro Thr His 
            340                 345                 350         


Arg Pro His Glu Ala Ser Pro Pro His Glu Thr His Arg Ala Arg Gly 
        355                 360                 365             


His Ile Ser Thr His Arg Thr His Arg Ala Ser Asn Ile Leu Glu Ala 
    370                 375                 380                 


Leu Ala Val Ala Leu Gly Leu Leu Tyr Ser Pro His Glu Gly Leu Ala 
385                 390                 395                 400 


Ser Asn Gly Leu Tyr Ser Glu Arg Thr Arg Pro Leu Tyr Ser Val Ala 
                405                 410                 415     


Leu Thr His Arg Ala Ser Asn Ile Leu Glu Ile Leu Glu Thr His Arg 
            420                 425                 430         


Pro Arg Ser Glu Arg Val Ala Leu Leu Glu Ile Leu Glu Pro His Glu 
        435                 440                 445             


Gly Leu Tyr Pro Arg Leu Glu Pro Arg Ala Ser Asn Ile Leu Glu Leu 
    450                 455                 460                 


Glu Ala Ser Pro Thr Tyr Arg Thr His Arg Ala Leu Ala Ser Glu Arg 
465                 470                 475                 480 


Leu Glu Thr His Arg Leu Glu Gly Leu Asn Gly Leu Tyr Gly Leu Asn 
                485                 490                 495     


Gly Leu Asn Ser Glu Arg Ala Ser Asn Pro Arg Ser Glu Arg Pro His 
            500                 505                 510         


Glu Gly Leu Gly Leu Tyr Pro His Glu Gly Leu Tyr Thr His Arg Leu 
        515                 520                 525             


Glu Ser Glu Arg Ile Leu Glu Leu Glu Leu Tyr Ser Val Ala Leu Ala 
    530                 535                 540                 


Leu Ala Pro Arg Gly Leu Pro His Glu Leu Glu Leu Glu Thr His Arg 
545                 550                 555                 560 


Pro His Glu Ser Glu Arg Ala Ser Pro Val Ala Leu Thr His Arg Ser 
                565                 570                 575     


Glu Arg Ala Ser Asn Gly Leu Asn Ser Glu Arg Ser Glu Arg Ala Leu 
            580                 585                 590         


Ala Val Ala Leu Leu Glu Gly Leu Tyr Leu Tyr Ser Ser Glu Arg Ile 
        595                 600                 605             


Leu Glu Pro His Glu Cys Tyr Ser Met Glu Thr Ala Ser Pro Pro Arg 
    610                 615                 620                 


Val Ala Leu Ile Leu Glu Ala Leu Ala Leu Glu Met Glu Thr His Ile 
625                 630                 635                 640 


Ser Gly Leu Leu Glu Thr His Arg His Ile Ser Ser Glu Arg Leu Glu 
                645                 650                 655     


His Ile Ser Gly Leu Asn Leu Glu Thr Tyr Arg Gly Leu Tyr Ile Leu 
            660                 665                 670         


Glu Ala Ser Asn Ile Leu Glu Pro Arg Ser Glu Arg Ala Ser Pro Leu 
        675                 680                 685             


Tyr Ser Ala Arg Gly Ile Leu Glu Ala Arg Gly Pro Arg Gly Leu Asn 
    690                 695                 700                 


Val Ala Leu Ser Glu Arg Gly Leu Gly Leu Tyr Pro His Glu Pro His 
705                 710                 715                 720 


Glu Ser Glu Arg Gly Leu Asn Ala Ser Pro Gly Leu Tyr Pro Arg Ala 
                725                 730                 735     


Ser Asn Val Ala Leu Gly Leu Asn Pro His Glu Gly Leu Gly Leu Leu 
            740                 745                 750         


Glu Thr Tyr Arg Thr His Arg Pro His Glu Gly Leu Tyr Gly Leu Tyr 
        755                 760                 765             


Ser Glu Arg Ala Ser Pro Val Ala Leu Gly Leu Ile Leu Glu Ile Leu 
    770                 775                 780                 


Glu Pro Arg Gly Leu Asn Ile Leu Glu Gly Leu Ala Arg Gly Leu Glu 
785                 790                 795                 800 


Gly Leu Asn Leu Glu Ala Arg Gly Gly Leu Leu Tyr Ser Ala Leu Ala 
                805                 810                 815     


Leu Glu Gly Leu Tyr His Ile Ser Thr Tyr Arg Leu Tyr Ser Ala Ser 
            820                 825                 830         


Pro Ile Leu Glu Ala Leu Ala Leu Tyr Ser Ala Arg Gly Leu Glu Ala 
        835                 840                 845             


Ser Asn Ala Ser Asn Ile Leu Glu Ala Ser Asn Leu Tyr Ser Thr His 
    850                 855                 860                 


Arg Ile Leu Glu Pro Arg Ser Glu Arg Ser Glu Arg Thr Arg Pro Ser 
865                 870                 875                 880 


Glu Arg Ser Glu Arg Ala Ser Asn Ile Leu Glu Ala Ser Pro Leu Tyr 
                885                 890                 895     


Ser Thr Tyr Arg Leu Tyr Ser Leu Tyr Ser Ile Leu Glu Pro His Glu 
            900                 905                 910         


Ser Glu Arg Gly Leu Leu Tyr Ser Thr Tyr Arg Ala Ser Asn Pro His 
        915                 920                 925             


Glu Ala Ser Pro Leu Tyr Ser Ala Ser Pro Ala Ser Asn Thr His Arg 
    930                 935                 940                 


Gly Leu Tyr Ala Ser Asn Pro His Glu Val Ala Leu Val Ala Leu Ala 
945                 950                 955                 960 


Ser Asn Ile Leu Glu Ala Ser Pro Leu Tyr Ser Pro His Glu Ala Ser 
                965                 970                 975     


Asn Ser Glu Arg Leu Glu Thr Tyr Arg Ser Glu Arg Ala Ser Pro Leu 
            980                 985                 990         


Glu Thr His Arg Ala Ser Asn Val  Ala Leu Met Glu Thr  Ser Glu Arg 
        995                 1000                 1005             


Gly Leu  Val Ala Leu Val Ala  Leu Thr Tyr Arg Ser  Glu Arg Ser 
    1010                 1015                 1020             


Glu Arg  Gly Leu Asn Thr Tyr  Arg Ala Ser Asn Val  Ala Leu Leu 
    1025                 1030                 1035             


Tyr Ser  Ala Ser Asn Ala Arg  Gly Thr His Arg His  Ile Ser Thr 
    1040                 1045                 1050             


Tyr Arg  Pro His Glu Ser Glu  Arg Leu Tyr Ser His  Ile Ser Thr 
    1055                 1060                 1065             


Tyr Arg  Leu Glu Pro Arg Val  Ala Leu Pro His Glu  Ala Leu Ala 
    1070                 1075                 1080             


Ala Ser  Asn Ile Leu Glu Leu  Glu Ala Ser Pro Ala  Ser Pro Ala 
    1085                 1090                 1095             


Ser Asn  Ile Leu Glu Thr Tyr  Arg Thr His Arg Ile  Leu Glu Ile 
    1100                 1105                 1110             


Leu Glu  Ala Ser Asn Gly Leu  Tyr Pro His Glu Ala  Ser Asn Leu 
    1115                 1120                 1125             


Glu Thr  His Arg Thr His Arg  Leu Tyr Ser Gly Leu  Tyr Pro His 
    1130                 1135                 1140             


Glu Ala  Ser Asn Ile Leu Glu  Gly Leu Ala Ser Asn  Ser Glu Arg 
    1145                 1150                 1155             


Gly Leu  Tyr Gly Leu Asn Ala  Ser Asn Ile Leu Glu  Gly Leu Ala 
    1160                 1165                 1170             


Arg Gly  Ala Ser Asn Pro Arg  Ala Leu Ala Leu Glu  Gly Leu Asn 
    1175                 1180                 1185             


Leu Tyr  Ser Leu Glu Ser Glu  Arg Ser Glu Arg Gly  Leu Ser Glu 
    1190                 1195                 1200             


Arg Val  Ala Leu Val Ala Leu  Ala Ser Pro Leu Glu  Pro His Glu 
    1205                 1210                 1215             


Thr His  Arg Leu Tyr Ser Val  Ala Leu Cys Tyr Ser  Leu Glu Ala 
    1220                 1225                 1230             


Arg Gly  Leu Glu Thr His Arg  Ala Arg Gly Ala Ser  Asn Ser Glu 
    1235                 1240                 1245             


Arg Ala  Arg Gly Ala Ser Pro  Ala Ser Pro Ser Glu  Arg Thr His 
    1250                 1255                 1260             


Arg Cys  Tyr Ser Ile Leu Glu  Gly Leu Asn Val Ala  Leu Leu Tyr 
    1265                 1270                 1275             


Ser Ala  Ser Asn Ala Ser Asn  Thr His Arg Leu Glu  Pro Arg Thr 
    1280                 1285                 1290             


Tyr Arg  Val Ala Leu Ala Leu  Ala Ala Ser Pro Leu  Tyr Ser Ala 
    1295                 1300                 1305             


Ser Pro  Ser Glu Arg Ile Leu  Glu Ser Glu Arg Gly  Leu Asn Gly 
    1310                 1315                 1320             


Leu Ile  Leu Glu Pro His Glu  Gly Leu Ser Glu Arg  Gly Leu Asn 
    1325                 1330                 1335             


Ile Leu  Glu Ile Leu Glu Thr  His Arg Ala Ser Pro  Gly Leu Thr 
    1340                 1345                 1350             


His Arg  Ala Ser Asn Val Ala  Leu Gly Leu Ala Ser  Asn Thr Tyr 
    1355                 1360                 1365             


Arg Ser  Glu Arg Ala Ser Pro  Ala Ser Asn Pro His  Glu Ser Glu 
    1370                 1375                 1380             


Arg Leu  Glu Ala Ser Pro Gly  Leu Ser Glu Arg Ile  Leu Glu Leu 
    1385                 1390                 1395             


Glu Ala  Ser Pro Ala Leu Ala  Leu Tyr Ser Val Ala  Leu Pro Arg 
    1400                 1405                 1410             


Thr His  Arg Ala Ser Asn Pro  Arg Gly Leu Ala Leu  Ala Val Ala 
    1415                 1420                 1425             


Leu Ala  Ser Pro Pro Arg Leu  Glu Leu Glu Pro Arg  Ala Ser Asn 
    1430                 1435                 1440             


Val Ala  Leu Ala Ser Asn Met  Glu Thr Gly Leu Pro  Arg Leu Glu 
    1445                 1450                 1455             


Ala Ser  Asn Val Ala Leu Pro  Arg Gly Leu Tyr Gly  Leu Gly Leu 
    1460                 1465                 1470             


Gly Leu  Val Ala Leu Pro His  Glu Thr Tyr Arg Ala  Ser Pro Ala 
    1475                 1480                 1485             


Ser Pro  Ile Leu Glu Thr His  Arg Leu Tyr Ser Ala  Ser Pro Val 
    1490                 1495                 1500             


Ala Leu  Ala Ser Pro Thr Tyr  Arg Leu Glu Ala Ser  Asn Ser Glu 
    1505                 1510                 1515             


Arg Thr  Tyr Arg Thr Tyr Arg  Thr Tyr Arg Leu Glu  Gly Leu Ala 
    1520                 1525                 1530             


Leu Ala  Gly Leu Asn Leu Tyr  Ser Leu Glu Ser Glu  Arg Ala Ser 
    1535                 1540                 1545             


Asn Ala  Ser Asn Val Ala Leu  Gly Leu Ala Ser Asn  Ile Leu Glu 
    1550                 1555                 1560             


Thr His  Arg Leu Glu Thr His  Arg Thr His Arg Ser  Glu Arg Val 
    1565                 1570                 1575             


Ala Leu  Gly Leu Gly Leu Ala  Leu Ala Leu Glu Gly  Leu Tyr Thr 
    1580                 1585                 1590             


Tyr Arg  Ser Glu Arg Ala Ser  Asn Leu Tyr Ser Ile  Leu Glu Thr 
    1595                 1600                 1605             


Tyr Arg  Thr His Arg Pro His  Glu Leu Glu Pro Arg  Ser Glu Arg 
    1610                 1615                 1620             


Leu Glu  Ala Leu Ala Gly Leu  Leu Tyr Ser Val Ala  Leu Ala Ser 
    1625                 1630                 1635             


Asn Leu  Tyr Ser Gly Leu Tyr  Val Ala Leu Gly Leu  Asn Ala Leu 
    1640                 1645                 1650             


Ala Gly  Leu Tyr Leu Glu Pro  His Glu Leu Glu Ala  Ser Asn Thr 
    1655                 1660                 1665             


Arg Pro  Ala Leu Ala Ala Ser  Asn Gly Leu Val Ala  Leu Val Ala 
    1670                 1675                 1680             


Leu Gly  Leu Ala Ser Pro Pro  His Glu Thr His Arg  Thr His Arg 
    1685                 1690                 1695             


Ala Ser  Asn Ile Leu Glu Met  Glu Thr Leu Tyr Ser  Leu Tyr Ser 
    1700                 1705                 1710             


Ala Ser  Pro Thr His Arg Leu  Glu Ala Ser Pro Leu  Tyr Ser Ile 
    1715                 1720                 1725             


Leu Glu  Ser Glu Arg Ala Ser  Pro Val Ala Leu Ser  Glu Arg Ala 
    1730                 1735                 1740             


Leu Ala  Ile Leu Glu Ile Leu  Glu Pro Arg Thr Tyr  Arg Ile Leu 
    1745                 1750                 1755             


Glu Gly  Leu Tyr Pro Arg Ala  Leu Ala Leu Glu Ala  Ser Asn Ile 
    1760                 1765                 1770             


Leu Glu  Gly Leu Tyr Ala Ser  Asn Ser Glu Arg Ala  Leu Ala Leu 
    1775                 1780                 1785             


Glu Ala  Arg Gly Gly Leu Tyr  Ala Ser Asn Pro His  Glu Leu Tyr 
    1790                 1795                 1800             


Ser Gly  Leu Asn Ala Leu Ala  Pro His Glu Ala Leu  Ala Thr His 
    1805                 1810                 1815             


Arg Ala  Leu Ala Gly Leu Tyr  Val Ala Leu Ala Leu  Ala Pro His 
    1820                 1825                 1830             


Glu Leu  Glu Leu Glu Gly Leu  Gly Leu Tyr Pro His  Glu Pro Arg 
    1835                 1840                 1845             


Gly Leu  Pro His Glu Thr His  Arg Ile Leu Glu Pro  Arg Ala Leu 
    1850                 1855                 1860             


Ala Leu  Glu Gly Leu Tyr Val  Ala Leu Pro His Glu  Thr His Arg 
    1865                 1870                 1875             


Pro His  Glu Thr Tyr Arg Ser  Glu Arg Ser Glu Arg  Ile Leu Glu 
    1880                 1885                 1890             


Gly Leu  Asn Gly Leu Ala Arg  Gly Gly Leu Leu Tyr  Ser Ile Leu 
    1895                 1900                 1905             


Glu Ile  Leu Glu Leu Tyr Ser  Thr His Arg Ile Leu  Glu Gly Leu 
    1910                 1915                 1920             


Ala Ser  Asn Cys Tyr Ser Leu  Glu Gly Leu Gly Leu  Asn Ala Arg 
    1925                 1930                 1935             


Gly Val  Ala Leu Leu Tyr Ser  Ala Arg Gly Thr Arg  Pro Leu Tyr 
    1940                 1945                 1950             


Ser Ala  Ser Pro Ser Glu Arg  Thr Tyr Arg Gly Leu  Asn Thr Arg 
    1955                 1960                 1965             


Pro Met  Glu Thr Val Ala Leu  Ser Glu Arg Ala Ser  Asn Thr Arg 
    1970                 1975                 1980             


Pro Leu  Glu Ser Glu Arg Ala  Arg Gly Ile Leu Glu  Thr His Arg 
    1985                 1990                 1995             


Thr His  Arg Ala Arg Gly Pro  His Glu Ala Ser Asn  His Ile Ser 
    2000                 2005                 2010             


Ile Leu  Glu Ser Glu Arg Thr  Tyr Arg Gly Leu Asn  Met Glu Thr 
    2015                 2020                 2025             


Thr Tyr  Arg Ala Ser Pro Ser  Glu Arg Leu Glu Ser  Glu Arg Thr 
    2030                 2035                 2040             


Tyr Arg  Gly Leu Asn Ala Leu  Ala Ala Ser Pro Ala  Leu Ala Ile 
    2045                 2050                 2055             


Leu Glu  Leu Tyr Ser Ala Leu  Ala Leu Tyr Ser Ile  Leu Glu Ala 
    2060                 2065                 2070             


Ser Pro  Leu Glu Gly Leu Thr  Tyr Arg Leu Tyr Ser  Leu Tyr Ser 
    2075                 2080                 2085             


Thr Tyr  Arg Ser Glu Arg Gly  Leu Tyr Ser Glu Arg  Ala Ser Pro 
    2090                 2095                 2100             


Leu Tyr  Ser Gly Leu Ala Ser  Asn Ile Leu Glu Leu  Tyr Ser Ser 
    2105                 2110                 2115             


Glu Arg  Gly Leu Asn Val Ala  Leu Gly Leu Ala Ser  Asn Leu Glu 
    2120                 2125                 2130             


Leu Tyr  Ser Ala Ser Asn Ser  Glu Arg Leu Glu Ala  Ser Pro Val 
    2135                 2140                 2145             


Ala Leu  Leu Tyr Ser Ile Leu  Glu Ser Glu Arg Gly  Leu Ala Leu 
    2150                 2155                 2160             


Ala Met  Glu Thr Ala Ser Asn  Ala Ser Asn Ile Leu  Glu Ala Ser 
    2165                 2170                 2175             


Asn Leu  Tyr Ser Pro His Glu  Ile Leu Glu Ala Arg  Gly Gly Leu 
    2180                 2185                 2190             


Cys Tyr  Ser Ser Glu Arg Val  Ala Leu Thr His Arg  Thr Tyr Arg 
    2195                 2200                 2205             


Leu Glu  Pro His Glu Leu Tyr  Ser Ala Ser Asn Met  Glu Thr Leu 
    2210                 2215                 2220             


Glu Pro  Arg Leu Tyr Ser Val  Ala Leu Ile Leu Glu  Ala Ser Pro 
    2225                 2230                 2235             


Gly Leu  Leu Glu Ala Ser Asn  Leu Tyr Ser Pro His  Glu Ala Ser 
    2240                 2245                 2250             


Pro Leu  Glu Leu Tyr Ser Thr  His Arg Leu Tyr Ser  Thr His Arg 
    2255                 2260                 2265             


Gly Leu  Leu Glu Ile Leu Glu  Ala Ser Asn Leu Glu  Ile Leu Glu 
    2270                 2275                 2280             


Ala Ser  Pro Ser Glu Arg His  Ile Ser Ala Ser Asn  Ile Leu Glu 
    2285                 2290                 2295             


Ile Leu  Glu Leu Glu Val Ala  Leu Gly Leu Tyr Gly  Leu Val Ala 
    2300                 2305                 2310             


Leu Ala  Ser Pro Ala Arg Gly  Leu Glu Leu Tyr Ser  Ala Leu Ala 
    2315                 2320                 2325             


Leu Tyr  Ser Val Ala Leu Ala  Ser Asn Gly Leu Ser  Glu Arg Pro 
    2330                 2335                 2340             


His Glu  Gly Leu Ala Ser Asn  Thr His Arg Ile Leu  Glu Pro Arg 
    2345                 2350                 2355             


Pro His  Glu Ala Ser Asn Ile  Leu Glu Pro His Glu  Ser Glu Arg 
    2360                 2365                 2370             


Thr Tyr  Arg Thr His Arg Ala  Ser Asn Ala Ser Asn  Ser Glu Arg 
    2375                 2380                 2385             


Leu Glu  Leu Glu Leu Tyr Ser  Ala Ser Pro Met Glu  Thr Ile Leu 
    2390                 2395                 2400             


Glu Ala  Ser Asn Gly Leu Thr  Tyr Arg Pro His Glu  Ala Ser Asn 
    2405                 2410                 2415             


Ser Glu  Arg Ile Leu Glu Ala  Ser Asn Ala Ser Pro  Ser Glu Arg 
    2420                 2425                 2430             


Leu Tyr  Ser Ile Leu Glu Leu  Glu Ser Glu Arg Leu  Glu Gly Leu 
    2435                 2440                 2445             


Asn Ala  Ser Asn Leu Tyr Ser  Leu Tyr Ser Ala Ser  Asn Thr His 
    2450                 2455                 2460             


Arg Leu  Glu Met Glu Thr Ala  Ser Pro Thr His Arg  Ser Glu Arg 
    2465                 2470                 2475             


Gly Leu  Tyr Thr Tyr Arg Ala  Ser Asn Ala Leu Ala  Gly Leu Val 
    2480                 2485                 2490             


Ala Leu  Ala Arg Gly Val Ala  Leu Gly Leu Gly Leu  Tyr Ala Ser 
    2495                 2500                 2505             


Asn Val  Ala Leu Gly Leu Asn  Leu Glu Ala Ser Asn  Pro Arg Ile 
    2510                 2515                 2520             


Leu Glu  Pro His Glu Pro Arg  Pro His Glu Ala Ser  Pro Pro His 
    2525                 2530                 2535             


Glu Leu  Tyr Ser Leu Glu Gly  Leu Tyr Ser Glu Arg  Ser Glu Arg 
    2540                 2545                 2550             


Gly Leu  Tyr Ala Ser Pro Ala  Ser Pro Ala Arg Gly  Gly Leu Tyr 
    2555                 2560                 2565             


Leu Tyr  Ser Val Ala Leu Ile  Leu Glu Val Ala Leu  Thr His Arg 
    2570                 2575                 2580             


Gly Leu  Asn Ala Ser Asn Gly  Leu Ala Ser Asn Ile  Leu Glu Val 
    2585                 2590                 2595             


Ala Leu  Thr Tyr Arg Ala Ser  Asn Ala Leu Ala Met  Glu Thr Thr 
    2600                 2605                 2610             


Tyr Arg  Gly Leu Ser Glu Arg  Pro His Glu Ser Glu  Arg Ile Leu 
    2615                 2620                 2625             


Glu Ser  Glu Arg Pro His Glu  Thr Arg Pro Ile Leu  Glu Ala Arg 
    2630                 2635                 2640             


Gly Ile  Leu Glu Ala Ser Asn  Leu Tyr Ser Thr Arg  Pro Val Ala 
    2645                 2650                 2655             


Leu Ser  Glu Arg Ala Ser Asn  Leu Glu Pro Arg Gly  Leu Tyr Thr 
    2660                 2665                 2670             


Tyr Arg  Thr His Arg Ile Leu  Glu Ile Leu Glu Ala  Ser Pro Ser 
    2675                 2680                 2685             


Glu Arg  Val Ala Leu Leu Tyr  Ser Ala Ser Asn Ala  Ser Asn Ser 
    2690                 2695                 2700             


Glu Arg  Gly Leu Tyr Thr Arg  Pro Ser Glu Arg Ile  Leu Glu Gly 
    2705                 2710                 2715             


Leu Tyr  Ile Leu Glu Ile Leu  Glu Ser Glu Arg Ala  Ser Asn Pro 
    2720                 2725                 2730             


His Glu  Leu Glu Val Ala Leu  Pro His Glu Thr His  Arg Leu Glu 
    2735                 2740                 2745             


Leu Tyr  Ser Gly Leu Asn Ala  Ser Asn Gly Leu Ala  Ser Asn Ser 
    2750                 2755                 2760             


Glu Arg  Gly Leu Gly Leu Asn  Ala Ser Pro Ile Leu  Glu Ala Ser 
    2765                 2770                 2775             


Asn Pro  His Glu Ser Glu Arg  Thr Tyr Arg Ala Ser  Pro Ile Leu 
    2780                 2785                 2790             


Glu Ser  Glu Arg Leu Tyr Ser  Ala Ser Asn Ala Leu  Ala Ala Leu 
    2795                 2800                 2805             


Ala Gly  Leu Tyr Thr Tyr Arg  Ala Ser Asn Leu Tyr  Ser Thr Arg 
    2810                 2815                 2820             


Pro Pro  His Glu Pro His Glu  Val Ala Leu Thr His  Arg Ile Leu 
    2825                 2830                 2835             


Glu Thr  His Arg Thr His Arg  Ala Ser Asn Met Glu  Thr Met Glu 
    2840                 2845                 2850             


Thr Gly  Leu Tyr Ala Ser Asn  Met Glu Thr Met Glu  Thr Ile Leu 
    2855                 2860                 2865             


Glu Thr  Tyr Arg Ile Leu Glu  Ala Ser Asn Gly Leu  Tyr Leu Tyr 
    2870                 2875                 2880             


Ser Leu  Glu Ile Leu Glu Ala  Ser Pro Thr His Arg  Ile Leu Glu 
    2885                 2890                 2895             


Leu Tyr  Ser Val Ala Leu Leu  Tyr Ser Gly Leu Leu  Glu Thr His 
    2900                 2905                 2910             


Arg Gly  Leu Tyr Ile Leu Glu  Ala Ser Asn Pro His  Glu Ser Glu 
    2915                 2920                 2925             


Arg Leu  Tyr Ser Thr His Arg  Ile Leu Glu Thr His  Arg Pro His 
    2930                 2935                 2940             


Glu Gly  Leu Asn Met Glu Thr  Ala Ser Asn Leu Tyr  Ser Ile Leu 
    2945                 2950                 2955             


Glu Pro  Arg Ala Ser Asn Thr  His Arg Gly Leu Tyr  Leu Glu Ile 
    2960                 2965                 2970             


Leu Glu  Thr His Arg Ser Glu  Arg Ala Ser Pro Ser  Glu Arg Ala 
    2975                 2980                 2985             


Ser Pro  Ala Ser Asn Ile Leu  Glu Ala Ser Asn Met  Glu Thr Thr 
    2990                 2995                 3000             


Arg Pro  Ile Leu Glu Ala Arg  Gly Ala Ser Pro Pro  His Glu Thr 
    3005                 3010                 3015             


Tyr Arg  Ile Leu Glu Pro His  Glu Ala Leu Ala Leu  Tyr Ser Gly 
    3020                 3025                 3030             


Leu Leu  Glu Ala Ser Pro Ala  Ser Pro Leu Tyr Ser  Ala Ser Pro 
    3035                 3040                 3045             


Ile Leu  Glu Ala Ser Asn Ile  Leu Glu Leu Glu Pro  His Glu Ala 
    3050                 3055                 3060             


Ser Asn  Ser Glu Arg Leu Glu  Gly Leu Asn Thr Tyr  Arg Thr His 
    3065                 3070                 3075             


Arg Ala  Ser Asn Val Ala Leu  Val Ala Leu Leu Tyr  Ser Ala Ser 
    3080                 3085                 3090             


Pro Thr  Tyr Arg Thr Arg Pro  Gly Leu Tyr Ala Ser  Asn Ala Ser 
    3095                 3100                 3105             


Pro Leu  Glu Ala Arg Gly Thr  Tyr Arg Ala Ser Pro  Leu Tyr Ser 
    3110                 3115                 3120             


Gly Leu  Thr Tyr Arg Thr Tyr  Arg Met Glu Thr Ile  Leu Glu Ala 
    3125                 3130                 3135             


Ser Asn  Val Ala Leu Ala Ser  Asn Thr Tyr Arg Met  Glu Thr Ala 
    3140                 3145                 3150             


Ser Asn  Ala Arg Gly Thr Tyr  Arg Met Glu Thr Ser  Glu Arg Leu 
    3155                 3160                 3165             


Tyr Ser  Leu Tyr Ser Gly Leu  Tyr Ala Ser Asn Gly  Leu Tyr Ile 
    3170                 3175                 3180             


Leu Glu  Val Ala Leu Pro His  Glu Ala Ser Asn Thr  His Arg Ala 
    3185                 3190                 3195             


Arg Gly  Leu Tyr Ser Ala Ser  Asn Ala Ser Asn Ala  Ser Asn Ala 
    3200                 3205                 3210             


Ser Pro  Pro His Glu Ala Ser  Asn Gly Leu Gly Leu  Tyr Thr Tyr 
    3215                 3220                 3225             


Arg Leu  Tyr Ser Ile Leu Glu  Ile Leu Glu Ile Leu  Glu Leu Tyr 
    3230                 3235                 3240             


Ser Ala  Arg Gly Ile Leu Glu  Ala Arg Gly Gly Leu  Tyr Ala Ser 
    3245                 3250                 3255             


Asn Thr  His Arg Ala Ser Asn  Ala Ser Pro Thr His  Arg Ala Arg 
    3260                 3265                 3270             


Gly Val  Ala Leu Ala Arg Gly  Gly Leu Tyr Gly Leu  Ala Ser Asn 
    3275                 3280                 3285             


Val Ala  Leu Leu Glu Thr Tyr  Arg Pro His Glu Ala  Ser Asn Thr 
    3290                 3295                 3300             


His Arg  Thr His Arg Ile Leu  Glu Ala Ser Pro Ala  Ser Asn Leu 
    3305                 3310                 3315             


Tyr Ser  Gly Leu Asn Thr Tyr  Arg Ser Glu Arg Leu  Glu Gly Leu 
    3320                 3325                 3330             


Tyr Met  Glu Thr Thr Tyr Arg  Leu Tyr Ser Pro Arg  Ser Glu Arg 
    3335                 3340                 3345             


Ala Arg  Gly Ala Ser Asn Leu  Glu Gly Leu Tyr Thr  His Arg Ala 
    3350                 3355                 3360             


Ser Pro  Leu Glu Val Ala Leu  Pro Arg Leu Glu Gly  Leu Tyr Ala 
    3365                 3370                 3375             


Leu Ala  Leu Glu Ala Ser Pro  Gly Leu Asn Pro Arg  Met Glu Thr 
    3380                 3385                 3390             


Ala Ser  Pro Gly Leu Ile Leu  Glu Ala Arg Gly Leu  Tyr Ser Thr 
    3395                 3400                 3405             


Tyr Arg  Gly Leu Tyr Ser Glu  Arg Pro His Glu Ile  Leu Glu Ile 
    3410                 3415                 3420             


Leu Glu  Gly Leu Asn Pro Arg  Cys Tyr Ser Ala Ser  Asn Thr His 
    3425                 3430                 3435             


Arg Pro  His Glu Ala Ser Pro  Thr Tyr Arg Thr Tyr  Arg Ala Leu 
    3440                 3445                 3450             


Ala Ser  Glu Arg Gly Leu Asn  Leu Glu Pro His Glu  Leu Glu Ser 
    3455                 3460                 3465             


Glu Arg  Ser Glu Arg Ala Ser  Asn Ala Leu Ala Thr  His Arg Thr 
    3470                 3475                 3480             


His Arg  Ala Ser Asn Ala Arg  Gly Leu Glu Gly Leu  Tyr Ile Leu 
    3485                 3490                 3495             


Glu Leu  Glu Ser Glu Arg Ile  Leu Glu Gly Leu Tyr  Ser Glu Arg 
    3500                 3505                 3510             


Thr Tyr  Arg Ser Glu Arg Pro  His Glu Leu Tyr Ser  Leu Glu Gly 
    3515                 3520                 3525             


Leu Tyr  Ala Ser Pro Ala Ser  Pro Thr Tyr Arg Thr  Arg Pro Pro 
    3530                 3535                 3540             


His Glu  Ala Ser Asn His Ile  Ser Gly Leu Thr Tyr  Arg Leu Glu 
    3545                 3550                 3555             


Ile Leu  Glu Pro Arg Val Ala  Leu Ile Leu Glu Leu  Tyr Ser Ile 
    3560                 3565                 3570             


Leu Glu  Gly Leu His Ile Ser  Thr Tyr Arg Ala Leu  Ala Ser Glu 
    3575                 3580                 3585             


Arg Leu  Glu Leu Glu Gly Leu  Ser Glu Arg Thr His  Arg Ser Glu 
    3590                 3595                 3600             


Arg Thr  His Arg His Ile Ser  Thr Arg Pro Val Ala  Leu Pro His 
    3605                 3610                 3615             


Glu Val  Ala Leu Pro Arg Ala  Leu Ala Ser Glu Arg  Gly Leu 
    3620                 3625                 3630         


<210>  9
<211>  3756
<212>  DNA
<213>  Clostridium botulinum

<400>  9
atgccaaaaa ttaatagttt taattataat gatcctgtta atgatagaac aattttatat       60

attaaaccag gcggttgtca agaattttat aaatcattta atattatgaa aaatatttgg      120

ataattccag agagaaatgt aattggtaca accccccaag attttcatcc gcctacttca      180

ttaaaaaatg gagatagtag ttattatgac cctaattatt tacaaagtga tgaagaaaag      240

gatagatttt taaaaatagt cacaaaaata tttaatagaa taaataataa tctttcagga      300

gggattttat tagaagaact gtcaaaagct aatccatatt tagggaatga taatactcca      360

gataatcaat tccatattgg tgatgcatca gcagttgaga ttaaattctc aaatggtagc      420

caagacatac tattacctaa tgttattata atgggagcag agcctgattt atttgaaact      480

aacagttcca atatttctct aagaaataat tatatgccaa gcaatcaccg ttttggatca      540

atagctatag taacattctc acctgaatat tcttttagat ttaatgataa ttgtatgaat      600

gaatttattc aagatcctgc tcttacatta atgcatgaat taatacattc attacatgga      660

ctatatgggg ctaaagggat tactacaaag tatactataa cacaaaaaca aaatccccta      720

ataacaaata taagaggtac aaatattgaa gaattcttaa cttttggagg tactgattta      780

aacattatta ctagtgctca gtccaatgat atctatacta atcttctagc tgattataaa      840

aaaatagcgt ctaaacttag caaagtacaa gtatctaatc cactacttaa tccttataaa      900

gatgtttttg aagcaaagta tggattagat aaagatgcta gcggaattta ttcggtaaat      960

ataaacaaat ttaatgatat ttttaaaaaa ttatacagct ttacggaatt tgatttacga     1020

actaaatttc aagttaaatg taggcaaact tatattggac agtataaata cttcaaactt     1080

tcaaacttgt taaatgattc tatttataat atatcagaag gctataatat aaataattta     1140

aaggtaaatt ttagaggaca gaatgcaaat ttaaatccta gaattattac accaattaca     1200

ggtagaggac tagtaaaaaa aatcattaga ttttgtaaaa atattgtttc tgtaaaaggc     1260

ataaggaaat caatatgtat cgaaataaat aatggtgagt tattttttgt ggcttccgag     1320

aatagttata atgatgataa tataaatact cctaaagaaa ttgacgatac agtaacttca     1380

aataataatt atgaaaatga tttagatcag gttattttaa attttaatag tgaatcagca     1440

cctggacttt cagatgaaaa attaaattta actatccaaa atgatgctta tataccaaaa     1500

tatgattcta atggaacaag tgatatagaa caacatgatg ttaatgaact taatgtattt     1560

ttctatttag atgcacagaa agtgcccgaa ggtgaaaata atgtcaatct cacctcttca     1620

attgatacag cattattaga acaacctaaa atatatacat ttttttcatc agaatttatt     1680

aataatgtca ataaacctgt gcaagcagca ttatttgtaa gctggataca acaagtgtta     1740

gtagatttta ctactgaagc taaccaaaaa agtactgttg ataaaattgc agatatttct     1800

atagttgttc catatatagg tcttgcttta aatataggaa atgaagcaca aaaaggaaat     1860

tttaaagatg cacttgaatt attaggagca ggtattttat tagaatttga acccgagctt     1920

ttaattccta caattttagt attcacgata aaatcttttt taggttcatc tgataataaa     1980

aataaagtta ttaaagcaat aaataatgca ttgaaagaaa gagatgaaaa atggaaagaa     2040

gtatatagtt ttatagtatc gaattggatg actaaaatta atacacaatt taataaaaga     2100

aaagaacaaa tgtatcaagc tttacaaaat caagtaaatg caattaaaac aataatagaa     2160

tctaagtata atagttatac tttagaggaa aaaaatgagc ttacaaataa atatgatatt     2220

aagcaaatag aaaatgaact taatcaaaag gtttctatag caatgaataa tatagacagg     2280

ttcttaactg aaagttctat atcctattta atgaaaataa taaatgaagt aaaaattaat     2340

aaattaagag aatatgatga gaatgtcaaa acgtatttat tgaattatat tatacaacat     2400

ggatcaatct tgggagagag tcagcaagaa ctaaattcta tggtaactga taccctaaat     2460

aatagtattc cttttaagct ttcttcttat acagatgata aaattttaat ttcatatttt     2520

aataaattct ttaagagaat taaaagtagt tcagttttaa atatgagata taaaaatgat     2580

aaatacgtag atacttcagg atatgattca aatataaata ttaatggaga tgtatataaa     2640

tatccaacta ataaaaatca atttggaata tataatgata aacttagtga agttaatata     2700

tctcaaaatg attacattat atatgataat aaatataaaa attttagtat tagtttttgg     2760

gtaagaattc ctaactatga taataagata gtaaatgtta ataatgaata cactataata     2820

aattgtatga gagataataa ttcaggatgg aaagtatctc ttaatcataa tgaaataatt     2880

tggacattcg aagataatcg aggaattaat caaaaattag catttaacta tggtaacgca     2940

aatggtattt ctgattatat aaataagtgg atttttgtaa ctataactaa tgatagatta     3000

ggagattcta aactttatat taatggaaat ttaatagatc aaaaatcaat tttaaattta     3060

ggtaatattc atgttagtga caatatatta tttaaaatag ttaattgtag ttatacaaga     3120

tatattggta ttagatattt taatattttt gataaagaat tagatgaaac agaaattcaa     3180

actttatata gcaatgaacc taatacaaat attttgaagg atttttgggg aaattatttg     3240

ctttatgaca aagaatacta tttattaaat gtgttaaaac caaataactt tattgatagg     3300

agaaaagatt ctactttaag cattaataat ataagaagca ctattctttt agctaataga     3360

ttatatagtg gaataaaagt taaaatacaa agagttaata atagtagtac taacgataat     3420

cttgttagaa agaatgatca ggtatatatt aattttgtag ccagcaaaac tcacttattt     3480

ccattatatg ctgatacagc taccacaaat aaagagaaaa caataaaaat atcatcatct     3540

ggcaatagat ttaatcaagt agtagttatg aattcagtag gaaattgtac aatgaatttt     3600

aaaaataata atggaaataa tattgggttg ttaggtttca aggcagatac tgtcgttgct     3660

agtacttggt attatacaca tatgagagat catacaaaca gcaatggatg tttttggaac     3720

tttatttctg aagaacatgg atggcaagaa aaataa                               3756


<210>  10
<211>  3552
<212>  PRT
<213>  Clostridium botulinum

<400>  10

Met Glu Thr Pro Arg Leu Tyr Ser Ile Leu Glu Ala Ser Asn Ser Glu 
1               5                   10                  15      


Arg Pro His Glu Ala Ser Asn Thr Tyr Arg Ala Ser Asn Ala Ser Pro 
            20                  25                  30          


Pro Arg Val Ala Leu Ala Ser Asn Ala Ser Pro Ala Arg Gly Thr His 
        35                  40                  45              


Arg Ile Leu Glu Leu Glu Thr Tyr Arg Ile Leu Glu Leu Tyr Ser Pro 
    50                  55                  60                  


Arg Gly Leu Tyr Gly Leu Tyr Cys Tyr Ser Gly Leu Asn Gly Leu Pro 
65                  70                  75                  80  


His Glu Thr Tyr Arg Leu Tyr Ser Ser Glu Arg Pro His Glu Ala Ser 
                85                  90                  95      


Asn Ile Leu Glu Met Glu Thr Leu Tyr Ser Ala Ser Asn Ile Leu Glu 
            100                 105                 110         


Thr Arg Pro Ile Leu Glu Ile Leu Glu Pro Arg Gly Leu Ala Arg Gly 
        115                 120                 125             


Ala Ser Asn Val Ala Leu Ile Leu Glu Gly Leu Tyr Thr His Arg Thr 
    130                 135                 140                 


His Arg Pro Arg Gly Leu Asn Ala Ser Pro Pro His Glu His Ile Ser 
145                 150                 155                 160 


Pro Arg Pro Arg Thr His Arg Ser Glu Arg Leu Glu Leu Tyr Ser Ala 
                165                 170                 175     


Ser Asn Gly Leu Tyr Ala Ser Pro Ser Glu Arg Ser Glu Arg Thr Tyr 
            180                 185                 190         


Arg Thr Tyr Arg Ala Ser Pro Pro Arg Ala Ser Asn Thr Tyr Arg Leu 
        195                 200                 205             


Glu Gly Leu Asn Ser Glu Arg Ala Ser Pro Gly Leu Gly Leu Leu Tyr 
    210                 215                 220                 


Ser Ala Ser Pro Ala Arg Gly Pro His Glu Leu Glu Leu Tyr Ser Ile 
225                 230                 235                 240 


Leu Glu Val Ala Leu Thr His Arg Leu Tyr Ser Ile Leu Glu Pro His 
                245                 250                 255     


Glu Ala Ser Asn Ala Arg Gly Ile Leu Glu Ala Ser Asn Ala Ser Asn 
            260                 265                 270         


Ala Ser Asn Leu Glu Ser Glu Arg Gly Leu Tyr Gly Leu Tyr Ile Leu 
        275                 280                 285             


Glu Leu Glu Leu Glu Gly Leu Gly Leu Leu Glu Ser Glu Arg Leu Tyr 
    290                 295                 300                 


Ser Ala Leu Ala Ala Ser Asn Pro Arg Thr Tyr Arg Leu Glu Gly Leu 
305                 310                 315                 320 


Tyr Ala Ser Asn Ala Ser Pro Ala Ser Asn Thr His Arg Pro Arg Ala 
                325                 330                 335     


Ser Pro Ala Ser Asn Gly Leu Asn Pro His Glu His Ile Ser Ile Leu 
            340                 345                 350         


Glu Gly Leu Tyr Ala Ser Pro Ala Leu Ala Ser Glu Arg Ala Leu Ala 
        355                 360                 365             


Val Ala Leu Gly Leu Ile Leu Glu Leu Tyr Ser Pro His Glu Ser Glu 
    370                 375                 380                 


Arg Ala Ser Asn Gly Leu Tyr Ser Glu Arg Gly Leu Asn Ala Ser Pro 
385                 390                 395                 400 


Ile Leu Glu Leu Glu Leu Glu Pro Arg Ala Ser Asn Val Ala Leu Ile 
                405                 410                 415     


Leu Glu Ile Leu Glu Met Glu Thr Gly Leu Tyr Ala Leu Ala Gly Leu 
            420                 425                 430         


Pro Arg Ala Ser Pro Leu Glu Pro His Glu Gly Leu Thr His Arg Ala 
        435                 440                 445             


Ser Asn Ser Glu Arg Ser Glu Arg Ala Ser Asn Ile Leu Glu Ser Glu 
    450                 455                 460                 


Arg Leu Glu Ala Arg Gly Ala Ser Asn Ala Ser Asn Thr Tyr Arg Met 
465                 470                 475                 480 


Glu Thr Pro Arg Ser Glu Arg Ala Ser Asn His Ile Ser Ala Arg Gly 
                485                 490                 495     


Pro His Glu Gly Leu Tyr Ser Glu Arg Ile Leu Glu Ala Leu Ala Ile 
            500                 505                 510         


Leu Glu Val Ala Leu Thr His Arg Pro His Glu Ser Glu Arg Pro Arg 
        515                 520                 525             


Gly Leu Thr Tyr Arg Ser Glu Arg Pro His Glu Ala Arg Gly Pro His 
    530                 535                 540                 


Glu Ala Ser Asn Ala Ser Pro Ala Ser Asn Cys Tyr Ser Met Glu Thr 
545                 550                 555                 560 


Ala Ser Asn Gly Leu Pro His Glu Ile Leu Glu Gly Leu Asn Ala Ser 
                565                 570                 575     


Pro Pro Arg Ala Leu Ala Leu Glu Thr His Arg Leu Glu Met Glu Thr 
            580                 585                 590         


His Ile Ser Gly Leu Leu Glu Ile Leu Glu His Ile Ser Ser Glu Arg 
        595                 600                 605             


Leu Glu His Ile Ser Gly Leu Tyr Leu Glu Thr Tyr Arg Gly Leu Tyr 
    610                 615                 620                 


Ala Leu Ala Leu Tyr Ser Gly Leu Tyr Ile Leu Glu Thr His Arg Thr 
625                 630                 635                 640 


His Arg Leu Tyr Ser Thr Tyr Arg Thr His Arg Ile Leu Glu Thr His 
                645                 650                 655     


Arg Gly Leu Asn Leu Tyr Ser Gly Leu Asn Ala Ser Asn Pro Arg Leu 
            660                 665                 670         


Glu Ile Leu Glu Thr His Arg Ala Ser Asn Ile Leu Glu Ala Arg Gly 
        675                 680                 685             


Gly Leu Tyr Thr His Arg Ala Ser Asn Ile Leu Glu Gly Leu Gly Leu 
    690                 695                 700                 


Pro His Glu Leu Glu Thr His Arg Pro His Glu Gly Leu Tyr Gly Leu 
705                 710                 715                 720 


Tyr Thr His Arg Ala Ser Pro Leu Glu Ala Ser Asn Ile Leu Glu Ile 
                725                 730                 735     


Leu Glu Thr His Arg Ser Glu Arg Ala Leu Ala Gly Leu Asn Ser Glu 
            740                 745                 750         


Arg Ala Ser Asn Ala Ser Pro Ile Leu Glu Thr Tyr Arg Thr His Arg 
        755                 760                 765             


Ala Ser Asn Leu Glu Leu Glu Ala Leu Ala Ala Ser Pro Thr Tyr Arg 
    770                 775                 780                 


Leu Tyr Ser Leu Tyr Ser Ile Leu Glu Ala Leu Ala Ser Glu Arg Leu 
785                 790                 795                 800 


Tyr Ser Leu Glu Ser Glu Arg Leu Tyr Ser Val Ala Leu Gly Leu Asn 
                805                 810                 815     


Val Ala Leu Ser Glu Arg Ala Ser Asn Pro Arg Leu Glu Leu Glu Ala 
            820                 825                 830         


Ser Asn Pro Arg Thr Tyr Arg Leu Tyr Ser Ala Ser Pro Val Ala Leu 
        835                 840                 845             


Pro His Glu Gly Leu Ala Leu Ala Leu Tyr Ser Thr Tyr Arg Gly Leu 
    850                 855                 860                 


Tyr Leu Glu Ala Ser Pro Leu Tyr Ser Ala Ser Pro Ala Leu Ala Ser 
865                 870                 875                 880 


Glu Arg Gly Leu Tyr Ile Leu Glu Thr Tyr Arg Ser Glu Arg Val Ala 
                885                 890                 895     


Leu Ala Ser Asn Ile Leu Glu Ala Ser Asn Leu Tyr Ser Pro His Glu 
            900                 905                 910         


Ala Ser Asn Ala Ser Pro Ile Leu Glu Pro His Glu Leu Tyr Ser Leu 
        915                 920                 925             


Tyr Ser Leu Glu Thr Tyr Arg Ser Glu Arg Pro His Glu Thr His Arg 
    930                 935                 940                 


Gly Leu Pro His Glu Ala Ser Pro Leu Glu Ala Arg Gly Thr His Arg 
945                 950                 955                 960 


Leu Tyr Ser Pro His Glu Gly Leu Asn Val Ala Leu Leu Tyr Ser Cys 
                965                 970                 975     


Tyr Ser Ala Arg Gly Gly Leu Asn Thr His Arg Thr Tyr Arg Ile Leu 
            980                 985                 990         


Glu Gly Leu Tyr Gly Leu Asn Thr  Tyr Arg Leu Tyr Ser  Thr Tyr Arg 
        995                 1000                 1005             


Pro His  Glu Leu Tyr Ser Leu  Glu Ser Glu Arg Ala  Ser Asn Leu 
    1010                 1015                 1020             


Glu Leu  Glu Ala Ser Asn Ala  Ser Pro Ser Glu Arg  Ile Leu Glu 
    1025                 1030                 1035             


Thr Tyr  Arg Ala Ser Asn Ile  Leu Glu Ser Glu Arg  Gly Leu Gly 
    1040                 1045                 1050             


Leu Tyr  Thr Tyr Arg Ala Ser  Asn Ile Leu Glu Ala  Ser Asn Ala 
    1055                 1060                 1065             


Ser Asn  Leu Glu Leu Tyr Ser  Val Ala Leu Ala Ser  Asn Pro His 
    1070                 1075                 1080             


Glu Ala  Arg Gly Gly Leu Tyr  Gly Leu Asn Ala Ser  Asn Ala Leu 
    1085                 1090                 1095             


Ala Ala  Ser Asn Leu Glu Ala  Ser Asn Pro Arg Ala  Arg Gly Ile 
    1100                 1105                 1110             


Leu Glu  Ile Leu Glu Thr His  Arg Pro Arg Ile Leu  Glu Thr His 
    1115                 1120                 1125             


Arg Gly  Leu Tyr Ala Arg Gly  Gly Leu Tyr Leu Glu  Val Ala Leu 
    1130                 1135                 1140             


Leu Tyr  Ser Leu Tyr Ser Ile  Leu Glu Ile Leu Glu  Ala Arg Gly 
    1145                 1150                 1155             


Pro His  Glu Cys Tyr Ser Leu  Tyr Ser Ala Ser Asn  Ile Leu Glu 
    1160                 1165                 1170             


Val Ala  Leu Ser Glu Arg Val  Ala Leu Leu Tyr Ser  Gly Leu Tyr 
    1175                 1180                 1185             


Ile Leu  Glu Ala Arg Gly Leu  Tyr Ser Ser Glu Arg  Ile Leu Glu 
    1190                 1195                 1200             


Cys Tyr  Ser Ile Leu Glu Gly  Leu Ile Leu Glu Ala  Ser Asn Ala 
    1205                 1210                 1215             


Ser Asn  Gly Leu Tyr Gly Leu  Leu Glu Pro His Glu  Pro His Glu 
    1220                 1225                 1230             


Val Ala  Leu Ala Leu Ala Ser  Glu Arg Gly Leu Ala  Ser Asn Ser 
    1235                 1240                 1245             


Glu Arg  Thr Tyr Arg Ala Ser  Asn Ala Ser Pro Ala  Ser Pro Ala 
    1250                 1255                 1260             


Ser Asn  Ile Leu Glu Ala Ser  Asn Thr His Arg Pro  Arg Leu Tyr 
    1265                 1270                 1275             


Ser Gly  Leu Ile Leu Glu Ala  Ser Pro Ala Ser Pro  Thr His Arg 
    1280                 1285                 1290             


Val Ala  Leu Thr His Arg Ser  Glu Arg Ala Ser Asn  Ala Ser Asn 
    1295                 1300                 1305             


Ala Ser  Asn Thr Tyr Arg Gly  Leu Ala Ser Asn Ala  Ser Pro Leu 
    1310                 1315                 1320             


Glu Ala  Ser Pro Gly Leu Asn  Val Ala Leu Ile Leu  Glu Leu Glu 
    1325                 1330                 1335             


Ala Ser  Asn Pro His Glu Ala  Ser Asn Ser Glu Arg  Gly Leu Ser 
    1340                 1345                 1350             


Glu Arg  Ala Leu Ala Pro Arg  Gly Leu Tyr Leu Glu  Ser Glu Arg 
    1355                 1360                 1365             


Ala Ser  Pro Gly Leu Leu Tyr  Ser Leu Glu Ala Ser  Asn Leu Glu 
    1370                 1375                 1380             


Thr His  Arg Ile Leu Glu Gly  Leu Asn Ala Ser Asn  Ala Ser Pro 
    1385                 1390                 1395             


Ala Leu  Ala Thr Tyr Arg Ile  Leu Glu Pro Arg Leu  Tyr Ser Thr 
    1400                 1405                 1410             


Tyr Arg  Ala Ser Pro Ser Glu  Arg Ala Ser Asn Gly  Leu Tyr Thr 
    1415                 1420                 1425             


His Arg  Ser Glu Arg Ala Ser  Pro Ile Leu Glu Gly  Leu Gly Leu 
    1430                 1435                 1440             


Asn His  Ile Ser Ala Ser Pro  Val Ala Leu Ala Ser  Asn Gly Leu 
    1445                 1450                 1455             


Leu Glu  Ala Ser Asn Val Ala  Leu Pro His Glu Pro  His Glu Thr 
    1460                 1465                 1470             


Tyr Arg  Leu Glu Ala Ser Pro  Ala Leu Ala Gly Leu  Asn Leu Tyr 
    1475                 1480                 1485             


Ser Val  Ala Leu Pro Arg Gly  Leu Gly Leu Tyr Gly  Leu Ala Ser 
    1490                 1495                 1500             


Asn Ala  Ser Asn Val Ala Leu  Ala Ser Asn Leu Glu  Thr His Arg 
    1505                 1510                 1515             


Ser Glu  Arg Ser Glu Arg Ile  Leu Glu Ala Ser Pro  Thr His Arg 
    1520                 1525                 1530             


Ala Leu  Ala Leu Glu Leu Glu  Gly Leu Gly Leu Asn  Pro Arg Leu 
    1535                 1540                 1545             


Tyr Ser  Ile Leu Glu Thr Tyr  Arg Thr His Arg Pro  His Glu Pro 
    1550                 1555                 1560             


His Glu  Ser Glu Arg Ser Glu  Arg Gly Leu Pro His  Glu Ile Leu 
    1565                 1570                 1575             


Glu Ala  Ser Asn Ala Ser Asn  Val Ala Leu Ala Ser  Asn Leu Tyr 
    1580                 1585                 1590             


Ser Pro  Arg Val Ala Leu Gly  Leu Asn Ala Leu Ala  Ala Leu Ala 
    1595                 1600                 1605             


Leu Glu  Pro His Glu Val Ala  Leu Ser Glu Arg Thr  Arg Pro Ile 
    1610                 1615                 1620             


Leu Glu  Gly Leu Asn Gly Leu  Asn Val Ala Leu Leu  Glu Val Ala 
    1625                 1630                 1635             


Leu Ala  Ser Pro Pro His Glu  Thr His Arg Thr His  Arg Gly Leu 
    1640                 1645                 1650             


Ala Leu  Ala Ala Ser Asn Gly  Leu Asn Leu Tyr Ser  Ser Glu Arg 
    1655                 1660                 1665             


Thr His  Arg Val Ala Leu Ala  Ser Pro Leu Tyr Ser  Ile Leu Glu 
    1670                 1675                 1680             


Ala Leu  Ala Ala Ser Pro Ile  Leu Glu Ser Glu Arg  Ile Leu Glu 
    1685                 1690                 1695             


Val Ala  Leu Val Ala Leu Pro  Arg Thr Tyr Arg Ile  Leu Glu Gly 
    1700                 1705                 1710             


Leu Tyr  Leu Glu Ala Leu Ala  Leu Glu Ala Ser Asn  Ile Leu Glu 
    1715                 1720                 1725             


Gly Leu  Tyr Ala Ser Asn Gly  Leu Ala Leu Ala Gly  Leu Asn Leu 
    1730                 1735                 1740             


Tyr Ser  Gly Leu Tyr Ala Ser  Asn Pro His Glu Leu  Tyr Ser Ala 
    1745                 1750                 1755             


Ser Pro  Ala Leu Ala Leu Glu  Gly Leu Leu Glu Leu  Glu Gly Leu 
    1760                 1765                 1770             


Tyr Ala  Leu Ala Gly Leu Tyr  Ile Leu Glu Leu Glu  Leu Glu Gly 
    1775                 1780                 1785             


Leu Pro  His Glu Gly Leu Pro  Arg Gly Leu Leu Glu  Leu Glu Ile 
    1790                 1795                 1800             


Leu Glu  Pro Arg Thr His Arg  Ile Leu Glu Leu Glu  Val Ala Leu 
    1805                 1810                 1815             


Pro His  Glu Thr His Arg Ile  Leu Glu Leu Tyr Ser  Ser Glu Arg 
    1820                 1825                 1830             


Pro His  Glu Leu Glu Gly Leu  Tyr Ser Glu Arg Ser  Glu Arg Ala 
    1835                 1840                 1845             


Ser Pro  Ala Ser Asn Leu Tyr  Ser Ala Ser Asn Leu  Tyr Ser Val 
    1850                 1855                 1860             


Ala Leu  Ile Leu Glu Leu Tyr  Ser Ala Leu Ala Ile  Leu Glu Ala 
    1865                 1870                 1875             


Ser Asn  Ala Ser Asn Ala Leu  Ala Leu Glu Leu Tyr  Ser Gly Leu 
    1880                 1885                 1890             


Ala Arg  Gly Ala Ser Pro Gly  Leu Leu Tyr Ser Thr  Arg Pro Leu 
    1895                 1900                 1905             


Tyr Ser  Gly Leu Val Ala Leu  Thr Tyr Arg Ser Glu  Arg Pro His 
    1910                 1915                 1920             


Glu Ile  Leu Glu Val Ala Leu  Ser Glu Arg Ala Ser  Asn Thr Arg 
    1925                 1930                 1935             


Pro Met  Glu Thr Thr His Arg  Leu Tyr Ser Ile Leu  Glu Ala Ser 
    1940                 1945                 1950             


Asn Thr  His Arg Gly Leu Asn  Pro His Glu Ala Ser  Asn Leu Tyr 
    1955                 1960                 1965             


Ser Ala  Arg Gly Leu Tyr Ser  Gly Leu Gly Leu Asn  Met Glu Thr 
    1970                 1975                 1980             


Thr Tyr  Arg Gly Leu Asn Ala  Leu Ala Leu Glu Gly  Leu Asn Ala 
    1985                 1990                 1995             


Ser Asn  Gly Leu Asn Val Ala  Leu Ala Ser Asn Ala  Leu Ala Ile 
    2000                 2005                 2010             


Leu Glu  Leu Tyr Ser Thr His  Arg Ile Leu Glu Ile  Leu Glu Gly 
    2015                 2020                 2025             


Leu Ser  Glu Arg Leu Tyr Ser  Thr Tyr Arg Ala Ser  Asn Ser Glu 
    2030                 2035                 2040             


Arg Thr  Tyr Arg Thr His Arg  Leu Glu Gly Leu Gly  Leu Leu Tyr 
    2045                 2050                 2055             


Ser Ala  Ser Asn Gly Leu Leu  Glu Thr His Arg Ala  Ser Asn Leu 
    2060                 2065                 2070             


Tyr Ser  Thr Tyr Arg Ala Ser  Pro Ile Leu Glu Leu  Tyr Ser Gly 
    2075                 2080                 2085             


Leu Asn  Ile Leu Glu Gly Leu  Ala Ser Asn Gly Leu  Leu Glu Ala 
    2090                 2095                 2100             


Ser Asn  Gly Leu Asn Leu Tyr  Ser Val Ala Leu Ser  Glu Arg Ile 
    2105                 2110                 2115             


Leu Glu  Ala Leu Ala Met Glu  Thr Ala Ser Asn Ala  Ser Asn Ile 
    2120                 2125                 2130             


Leu Glu  Ala Ser Pro Ala Arg  Gly Pro His Glu Leu  Glu Thr His 
    2135                 2140                 2145             


Arg Gly  Leu Ser Glu Arg Ser  Glu Arg Ile Leu Glu  Ser Glu Arg 
    2150                 2155                 2160             


Thr Tyr  Arg Leu Glu Met Glu  Thr Leu Tyr Ser Ile  Leu Glu Ile 
    2165                 2170                 2175             


Leu Glu  Ala Ser Asn Gly Leu  Val Ala Leu Leu Tyr  Ser Ile Leu 
    2180                 2185                 2190             


Glu Ala  Ser Asn Leu Tyr Ser  Leu Glu Ala Arg Gly  Gly Leu Thr 
    2195                 2200                 2205             


Tyr Arg  Ala Ser Pro Gly Leu  Ala Ser Asn Val Ala  Leu Leu Tyr 
    2210                 2215                 2220             


Ser Thr  His Arg Thr Tyr Arg  Leu Glu Leu Glu Ala  Ser Asn Thr 
    2225                 2230                 2235             


Tyr Arg  Ile Leu Glu Ile Leu  Glu Gly Leu Asn His  Ile Ser Gly 
    2240                 2245                 2250             


Leu Tyr  Ser Glu Arg Ile Leu  Glu Leu Glu Gly Leu  Tyr Gly Leu 
    2255                 2260                 2265             


Ser Glu  Arg Gly Leu Asn Gly  Leu Asn Gly Leu Leu  Glu Ala Ser 
    2270                 2275                 2280             


Asn Ser  Glu Arg Met Glu Thr  Val Ala Leu Thr His  Arg Ala Ser 
    2285                 2290                 2295             


Pro Thr  His Arg Leu Glu Ala  Ser Asn Ala Ser Asn  Ser Glu Arg 
    2300                 2305                 2310             


Ile Leu  Glu Pro Arg Pro His  Glu Leu Tyr Ser Leu  Glu Ser Glu 
    2315                 2320                 2325             


Arg Ser  Glu Arg Thr Tyr Arg  Thr His Arg Ala Ser  Pro Ala Ser 
    2330                 2335                 2340             


Pro Leu  Tyr Ser Ile Leu Glu  Leu Glu Ile Leu Glu  Ser Glu Arg 
    2345                 2350                 2355             


Thr Tyr  Arg Pro His Glu Ala  Ser Asn Leu Tyr Ser  Pro His Glu 
    2360                 2365                 2370             


Pro His  Glu Leu Tyr Ser Ala  Arg Gly Ile Leu Glu  Leu Tyr Ser 
    2375                 2380                 2385             


Ser Glu  Arg Ser Glu Arg Ser  Glu Arg Val Ala Leu  Leu Glu Ala 
    2390                 2395                 2400             


Ser Asn  Met Glu Thr Ala Arg  Gly Thr Tyr Arg Leu  Tyr Ser Ala 
    2405                 2410                 2415             


Ser Asn  Ala Ser Pro Leu Tyr  Ser Thr Tyr Arg Val  Ala Leu Ala 
    2420                 2425                 2430             


Ser Pro  Thr His Arg Ser Glu  Arg Gly Leu Tyr Thr  Tyr Arg Ala 
    2435                 2440                 2445             


Ser Pro  Ser Glu Arg Ala Ser  Asn Ile Leu Glu Ala  Ser Asn Ile 
    2450                 2455                 2460             


Leu Glu  Ala Ser Asn Gly Leu  Tyr Ala Ser Pro Val  Ala Leu Thr 
    2465                 2470                 2475             


Tyr Arg  Leu Tyr Ser Thr Tyr  Arg Pro Arg Thr His  Arg Ala Ser 
    2480                 2485                 2490             


Asn Leu  Tyr Ser Ala Ser Asn  Gly Leu Asn Pro His  Glu Gly Leu 
    2495                 2500                 2505             


Tyr Ile  Leu Glu Thr Tyr Arg  Ala Ser Asn Ala Ser  Pro Leu Tyr 
    2510                 2515                 2520             


Ser Leu  Glu Ser Glu Arg Gly  Leu Val Ala Leu Ala  Ser Asn Ile 
    2525                 2530                 2535             


Leu Glu  Ser Glu Arg Gly Leu  Asn Ala Ser Asn Ala  Ser Pro Thr 
    2540                 2545                 2550             


Tyr Arg  Ile Leu Glu Ile Leu  Glu Thr Tyr Arg Ala  Ser Pro Ala 
    2555                 2560                 2565             


Ser Asn  Leu Tyr Ser Thr Tyr  Arg Leu Tyr Ser Ala  Ser Asn Pro 
    2570                 2575                 2580             


His Glu  Ser Glu Arg Ile Leu  Glu Ser Glu Arg Pro  His Glu Thr 
    2585                 2590                 2595             


Arg Pro  Val Ala Leu Ala Arg  Gly Ile Leu Glu Pro  Arg Ala Ser 
    2600                 2605                 2610             


Asn Thr  Tyr Arg Ala Ser Pro  Ala Ser Asn Leu Tyr  Ser Ile Leu 
    2615                 2620                 2625             


Glu Val  Ala Leu Ala Ser Asn  Val Ala Leu Ala Ser  Asn Ala Ser 
    2630                 2635                 2640             


Asn Gly  Leu Thr Tyr Arg Thr  His Arg Ile Leu Glu  Ile Leu Glu 
    2645                 2650                 2655             


Ala Ser  Asn Cys Tyr Ser Met  Glu Thr Ala Arg Gly  Ala Ser Pro 
    2660                 2665                 2670             


Ala Ser  Asn Ala Ser Asn Ser  Glu Arg Gly Leu Tyr  Thr Arg Pro 
    2675                 2680                 2685             


Leu Tyr  Ser Val Ala Leu Ser  Glu Arg Leu Glu Ala  Ser Asn His 
    2690                 2695                 2700             


Ile Ser  Ala Ser Asn Gly Leu  Ile Leu Glu Ile Leu  Glu Thr Arg 
    2705                 2710                 2715             


Pro Thr  His Arg Pro His Glu  Gly Leu Ala Ser Pro  Ala Ser Asn 
    2720                 2725                 2730             


Ala Arg  Gly Gly Leu Tyr Ile  Leu Glu Ala Ser Asn  Gly Leu Asn 
    2735                 2740                 2745             


Leu Tyr  Ser Leu Glu Ala Leu  Ala Pro His Glu Ala  Ser Asn Thr 
    2750                 2755                 2760             


Tyr Arg  Gly Leu Tyr Ala Ser  Asn Ala Leu Ala Ala  Ser Asn Gly 
    2765                 2770                 2775             


Leu Tyr  Ile Leu Glu Ser Glu  Arg Ala Ser Pro Thr  Tyr Arg Ile 
    2780                 2785                 2790             


Leu Glu  Ala Ser Asn Leu Tyr  Ser Thr Arg Pro Ile  Leu Glu Pro 
    2795                 2800                 2805             


His Glu  Val Ala Leu Thr His  Arg Ile Leu Glu Thr  His Arg Ala 
    2810                 2815                 2820             


Ser Asn  Ala Ser Pro Ala Arg  Gly Leu Glu Gly Leu  Tyr Ala Ser 
    2825                 2830                 2835             


Pro Ser  Glu Arg Leu Tyr Ser  Leu Glu Thr Tyr Arg  Ile Leu Glu 
    2840                 2845                 2850             


Ala Ser  Asn Gly Leu Tyr Ala  Ser Asn Leu Glu Ile  Leu Glu Ala 
    2855                 2860                 2865             


Ser Pro  Gly Leu Asn Leu Tyr  Ser Ser Glu Arg Ile  Leu Glu Leu 
    2870                 2875                 2880             


Glu Ala  Ser Asn Leu Glu Gly  Leu Tyr Ala Ser Asn  Ile Leu Glu 
    2885                 2890                 2895             


His Ile  Ser Val Ala Leu Ser  Glu Arg Ala Ser Pro  Ala Ser Asn 
    2900                 2905                 2910             


Ile Leu  Glu Leu Glu Pro His  Glu Leu Tyr Ser Ile  Leu Glu Val 
    2915                 2920                 2925             


Ala Leu  Ala Ser Asn Cys Tyr  Ser Ser Glu Arg Thr  Tyr Arg Thr 
    2930                 2935                 2940             


His Arg  Ala Arg Gly Thr Tyr  Arg Ile Leu Glu Gly  Leu Tyr Ile 
    2945                 2950                 2955             


Leu Glu  Ala Arg Gly Thr Tyr  Arg Pro His Glu Ala  Ser Asn Ile 
    2960                 2965                 2970             


Leu Glu  Pro His Glu Ala Ser  Pro Leu Tyr Ser Gly  Leu Leu Glu 
    2975                 2980                 2985             


Ala Ser  Pro Gly Leu Thr His  Arg Gly Leu Ile Leu  Glu Gly Leu 
    2990                 2995                 3000             


Asn Thr  His Arg Leu Glu Thr  Tyr Arg Ser Glu Arg  Ala Ser Asn 
    3005                 3010                 3015             


Gly Leu  Pro Arg Ala Ser Asn  Thr His Arg Ala Ser  Asn Ile Leu 
    3020                 3025                 3030             


Glu Leu  Glu Leu Tyr Ser Ala  Ser Pro Pro His Glu  Thr Arg Pro 
    3035                 3040                 3045             


Gly Leu  Tyr Ala Ser Asn Thr  Tyr Arg Leu Glu Leu  Glu Thr Tyr 
    3050                 3055                 3060             


Arg Ala  Ser Pro Leu Tyr Ser  Gly Leu Thr Tyr Arg  Thr Tyr Arg 
    3065                 3070                 3075             


Leu Glu  Leu Glu Ala Ser Asn  Val Ala Leu Leu Glu  Leu Tyr Ser 
    3080                 3085                 3090             


Pro Arg  Ala Ser Asn Ala Ser  Asn Pro His Glu Ile  Leu Glu Ala 
    3095                 3100                 3105             


Ser Pro  Ala Arg Gly Ala Arg  Gly Leu Tyr Ser Ala  Ser Pro Ser 
    3110                 3115                 3120             


Glu Arg  Thr His Arg Leu Glu  Ser Glu Arg Ile Leu  Glu Ala Ser 
    3125                 3130                 3135             


Asn Ala  Ser Asn Ile Leu Glu  Ala Arg Gly Ser Glu  Arg Thr His 
    3140                 3145                 3150             


Arg Ile  Leu Glu Leu Glu Leu  Glu Ala Leu Ala Ala  Ser Asn Ala 
    3155                 3160                 3165             


Arg Gly  Leu Glu Thr Tyr Arg  Ser Glu Arg Gly Leu  Tyr Ile Leu 
    3170                 3175                 3180             


Glu Leu  Tyr Ser Val Ala Leu  Leu Tyr Ser Ile Leu  Glu Gly Leu 
    3185                 3190                 3195             


Asn Ala  Arg Gly Val Ala Leu  Ala Ser Asn Ala Ser  Asn Ser Glu 
    3200                 3205                 3210             


Arg Ser  Glu Arg Thr His Arg  Ala Ser Asn Ala Ser  Pro Ala Ser 
    3215                 3220                 3225             


Asn Leu  Glu Val Ala Leu Ala  Arg Gly Leu Tyr Ser  Ala Ser Asn 
    3230                 3235                 3240             


Ala Ser  Pro Gly Leu Asn Val  Ala Leu Thr Tyr Arg  Ile Leu Glu 
    3245                 3250                 3255             


Ala Ser  Asn Pro His Glu Val  Ala Leu Ala Leu Ala  Ser Glu Arg 
    3260                 3265                 3270             


Leu Tyr  Ser Thr His Arg His  Ile Ser Leu Glu Pro  His Glu Pro 
    3275                 3280                 3285             


Arg Leu  Glu Thr Tyr Arg Ala  Leu Ala Ala Ser Pro  Thr His Arg 
    3290                 3295                 3300             


Ala Leu  Ala Thr His Arg Thr  His Arg Ala Ser Asn  Leu Tyr Ser 
    3305                 3310                 3315             


Gly Leu  Leu Tyr Ser Thr His  Arg Ile Leu Glu Leu  Tyr Ser Ile 
    3320                 3325                 3330             


Leu Glu  Ser Glu Arg Ser Glu  Arg Ser Glu Arg Gly  Leu Tyr Ala 
    3335                 3340                 3345             


Ser Asn  Ala Arg Gly Pro His  Glu Ala Ser Asn Gly  Leu Asn Val 
    3350                 3355                 3360             


Ala Leu  Val Ala Leu Val Ala  Leu Met Glu Thr Ala  Ser Asn Ser 
    3365                 3370                 3375             


Glu Arg  Val Ala Leu Gly Leu  Tyr Ala Ser Asn Cys  Tyr Ser Thr 
    3380                 3385                 3390             


His Arg  Met Glu Thr Ala Ser  Asn Pro His Glu Leu  Tyr Ser Ala 
    3395                 3400                 3405             


Ser Asn  Ala Ser Asn Ala Ser  Asn Gly Leu Tyr Ala  Ser Asn Ala 
    3410                 3415                 3420             


Ser Asn  Ile Leu Glu Gly Leu  Tyr Leu Glu Leu Glu  Gly Leu Tyr 
    3425                 3430                 3435             


Pro His  Glu Leu Tyr Ser Ala  Leu Ala Ala Ser Pro  Thr His Arg 
    3440                 3445                 3450             


Val Ala  Leu Val Ala Leu Ala  Leu Ala Ser Glu Arg  Thr His Arg 
    3455                 3460                 3465             


Thr Arg  Pro Thr Tyr Arg Thr  Tyr Arg Thr His Arg  His Ile Ser 
    3470                 3475                 3480             


Met Glu  Thr Ala Arg Gly Ala  Ser Pro His Ile Ser  Thr His Arg 
    3485                 3490                 3495             


Ala Ser  Asn Ser Glu Arg Ala  Ser Asn Gly Leu Tyr  Cys Tyr Ser 
    3500                 3505                 3510             


Pro His  Glu Thr Arg Pro Ala  Ser Asn Pro His Glu  Ile Leu Glu 
    3515                 3520                 3525             


Ser Glu  Arg Gly Leu Gly Leu  His Ile Ser Gly Leu  Tyr Thr Arg 
    3530                 3535                 3540             


Pro Gly  Leu Asn Gly Leu Leu  Tyr Ser 
    3545                 3550         


<210>  11
<211>  3843
<212>  DNA
<213>  Clostridium botulinum

<400>  11
atgccagttg taataaatag ttttaattat aatgaccctg ttaatgatga gacaatttta       60

tacatgcaga aaccatatga agaaagaagt agaaaatatt ataaagcttt tgagattatg      120

cctaatgttt ggataatgcc tgagagagat acaataggaa ctaagcctga tgagtttcag      180

gtgccggatt cattaaagaa cggaagtagt gcttattatg atcctaatta tttaaccact      240

gatgctgaaa aagatagata tttaaaaaca atgataaaat tatttaatag aattaatagt      300

aatcctacag ggaaagtttt gttagaagaa gtatcaaatg ctagaccata tttaggagat      360

gatgacacgc taattaatga attccttcca gttaatgtaa ctacaagtgt taatataaaa      420

ttttcaactg atgttgaaag ttcaataata tcgaatcttc ttgtattggg agcaggacct      480

gatatattta aagcttactg tacccccctt gtaaggttta ataagtcaga taaattaatt      540

gaaccaagta atcatggttt tggatcaatt aatatcttga cattttcacc tgagtatgaa      600

catattttta atgatattag tggagggaat cataatagta cagaatcatt tattgcagat      660

cctgcaattt cactagctca tgaattgata catgcactac atggattata cggggctaag      720

gcagttactc ataaagagtc tctagtagca gagcgaggac ctcttatgat agccgaaaag      780

cccataaggc tagaagaatt tttaactttt ggaggtgagg atttaaatat cattcctagt      840

gctatgaagg aaaaaatata taacgatctt ttagctaact atgaaaaaat agctactaga      900

cttagagaag ttaatacggc tcctcctgga tatgatatta atgaatataa agattatttt      960

caatggaagt atggactaga tagaaatgca gatggaagtt atactgtgaa tagaaataaa     1020

tttaatgaaa tttataaaaa attatatagc tttacagaga ttgacttagc aaataaattt     1080

aaagtaaaat gtagaaatac ttattttatt aaatatggat ttgtaaaagt tccaaatttg     1140

ttagatgatg atatttatac tgtatcagag gggtttaata taggtaattt agcagtaaac     1200

aatcgcggac aaaatataaa tttaaatcct aaaattattg attccattcc agataaaggt     1260

ttagtggaaa agattattaa attttgtaag agcattattc ctagaaaagg tacgaagcag     1320

tcaccgtcac tatgcattag agtaaataat agggagttat tttttgtagc ttcagaaagt     1380

agctataatg aaagtgatat taatacacct aaagaaattg acgatacaac aaatctaaat     1440

aataattata gaaataattt agatgaagtt attttagatt ataatagtga gacaatacct     1500

caaatatcaa atcgaacatt aaatacactt gtacaagaca atagttatgt gccaagatat     1560

gattctaatg gaacaagtga aatagaggaa tatgatgttg ttgactttaa tgtatttttc     1620

tatttacatg cacaaaaagt accagaaggt gaaaccaata taagtttaac ttcttcaatt     1680

gatacagcat tattagaaga atccaaagta tatacatttt tttcttcaga gtttatcgat     1740

actatcaata aacctgtaaa tgcagcacta tttatagatt ggataagcaa agtaataaga     1800

gattttacca ctgaagctac acaaaaaagt actgttgata agattgcaga catatcttta     1860

attgtaccct atgtaggtct tgctttgaat atagttattg aggcagaaaa aggaaatttt     1920

gaggaggcat ttgaattatt aggagcgggt attttattag aatttgtgcc agagcttaca     1980

attcctgtaa ttttagtgtt tacgataaaa tcctatatag attcatatga gaataaaaat     2040

aaagcaatta aagcaataaa taattcatta atcgaaagag aagcaaagtg gaaagaaata     2100

tatagttgga tagtatcaaa ttggcttact agaattaata cgcaatttaa taaaagaaaa     2160

gagcaaatgt atcaggcttt acaaaatcaa gtagatgcaa taaaaacagc aatagaatat     2220

aaatataata attatacttc agatgagaaa aatagacttg aatctaaata taatatcaat     2280

aatatagaag aagaattgaa taaaaaagtt tctttagcaa tgaaaaatat agaaagattt     2340

atgacagaaa gttctatatc ttatttaatg aaattaataa atgaagccga agttggtaaa     2400

ttaaaagaat atgataaaca tgttaagagc gatttattag actatattct ctaccataaa     2460

ttaatcttag gagagcagac aaaggaatta attgatttgg tgactagtac tttgaatagt     2520

agtattccat ttgaactttc ttcatatact aatgataaaa ttctaattat atattttaat     2580

agattatata aaaaaattaa agatagttct attttagata tgcgatatga aaataataaa     2640

tttatagata tctctggata tggttcaaat ataagcatta atggaaacgt atatatttat     2700

tcaacaaata gaaatcaatt tggaatatat agtggtaggc ttagtgaagt taatatagct     2760

caaaataatg atattatata caatagtaga tatcaaaatt ttagtattag tttctgggta     2820

accattccta aacactacag acctatgaat cgtaatcggg aatacactat aataaattgt     2880

atggggaata ataattcggg atggaaaata tcacttagaa ctattagaga ttgtgaaata     2940

atttggactt tacaagatac ttccggaaat aaggaaaaat taatttttag gtatgaagaa     3000

cttgctagta tatctgatta tataaataaa tggatttttg taactattac taataataga     3060

ttaggcaatt ctagaattta catcaatgga aatttaatag ttgaaaaatc aatttcgaat     3120

ttaggtgata ttcatgttag tgataatata ttatttaaaa ttgttggttg tgatgatgaa     3180

acgtatgttg gtataagata ttttaaagtt tttaatacgg aattagataa aacagaaatt     3240

gagactttat atagtaatga gccagatcca agtatcttaa aagactattg gggaaattat     3300

ttgctatata ataaaaaata ttatttattc aatttactaa gaaaagataa gtatattact     3360

cggaattcag gcattttaaa tattaatcaa caaagaggtg ttactggagg catatctgtt     3420

tttttgaact ataaattata tgaaggagta gaagttatta taagaaaaaa tgctcctata     3480

gatatatcta atacagataa ttttgttaga aaaaacgatc tagcatacat taatgtagta     3540

gatcatggtg tagaatatcg gttatatgct gatatatcaa ttacaaaatc agagaaaata     3600

ataaaattaa taagaacatc taatccaaac gatagcttag gtcaaattat agttatggat     3660

tcaataggaa ataattgcac aatgaatttt caaaacaatg atgggagcaa tataggatta     3720

ctaggttttc attcagatga tttggttgct agtagttggt attataacca tatacgaaga     3780

aacactagca gtaatggatg cttttggagt tttatttcta aagagcatgg ttggaaagaa     3840

taa                                                                   3843


<210>  12
<211>  3604
<212>  PRT
<213>  Clostridium botulinum

<400>  12

Met Glu Thr Pro Arg Val Ala Leu Val Ala Leu Ile Leu Glu Ala Ser 
1               5                   10                  15      


Asn Ser Glu Arg Pro His Glu Ala Ser Asn Thr Tyr Arg Ala Ser Asn 
            20                  25                  30          


Ala Ser Pro Pro Arg Val Ala Leu Ala Ser Asn Ala Ser Pro Gly Leu 
        35                  40                  45              


Thr His Arg Ile Leu Glu Leu Glu Thr Tyr Arg Met Glu Thr Gly Leu 
    50                  55                  60                  


Asn Leu Tyr Ser Pro Arg Thr Tyr Arg Gly Leu Gly Leu Ala Arg Gly 
65                  70                  75                  80  


Ser Glu Arg Ala Arg Gly Leu Tyr Ser Thr Tyr Arg Thr Tyr Arg Leu 
                85                  90                  95      


Tyr Ser Ala Leu Ala Pro His Glu Gly Leu Ile Leu Glu Met Glu Thr 
            100                 105                 110         


Pro Arg Ala Ser Asn Val Ala Leu Thr Arg Pro Ile Leu Glu Met Glu 
        115                 120                 125             


Thr Pro Arg Gly Leu Ala Arg Gly Ala Ser Pro Thr His Arg Ile Leu 
    130                 135                 140                 


Glu Gly Leu Tyr Thr His Arg Leu Tyr Ser Pro Arg Ala Ser Pro Gly 
145                 150                 155                 160 


Leu Pro His Glu Gly Leu Asn Val Ala Leu Pro Arg Ala Ser Pro Ser 
                165                 170                 175     


Glu Arg Leu Glu Leu Tyr Ser Ala Ser Asn Gly Leu Tyr Ser Glu Arg 
            180                 185                 190         


Ser Glu Arg Ala Leu Ala Thr Tyr Arg Thr Tyr Arg Ala Ser Pro Pro 
        195                 200                 205             


Arg Ala Ser Asn Thr Tyr Arg Leu Glu Thr His Arg Thr His Arg Ala 
    210                 215                 220                 


Ser Pro Ala Leu Ala Gly Leu Leu Tyr Ser Ala Ser Pro Ala Arg Gly 
225                 230                 235                 240 


Thr Tyr Arg Leu Glu Leu Tyr Ser Thr His Arg Met Glu Thr Ile Leu 
                245                 250                 255     


Glu Leu Tyr Ser Leu Glu Pro His Glu Ala Ser Asn Ala Arg Gly Ile 
            260                 265                 270         


Leu Glu Ala Ser Asn Ser Glu Arg Ala Ser Asn Pro Arg Thr His Arg 
        275                 280                 285             


Gly Leu Tyr Leu Tyr Ser Val Ala Leu Leu Glu Leu Glu Gly Leu Gly 
    290                 295                 300                 


Leu Val Ala Leu Ser Glu Arg Ala Ser Asn Ala Leu Ala Ala Arg Gly 
305                 310                 315                 320 


Pro Arg Thr Tyr Arg Leu Glu Gly Leu Tyr Ala Ser Pro Ala Ser Pro 
                325                 330                 335     


Ala Ser Pro Thr His Arg Leu Glu Ile Leu Glu Ala Ser Asn Gly Leu 
            340                 345                 350         


Pro His Glu Leu Glu Pro Arg Val Ala Leu Ala Ser Asn Val Ala Leu 
        355                 360                 365             


Thr His Arg Thr His Arg Ser Glu Arg Val Ala Leu Ala Ser Asn Ile 
    370                 375                 380                 


Leu Glu Leu Tyr Ser Pro His Glu Ser Glu Arg Thr His Arg Ala Ser 
385                 390                 395                 400 


Pro Val Ala Leu Gly Leu Ser Glu Arg Ser Glu Arg Ile Leu Glu Ile 
                405                 410                 415     


Leu Glu Ser Glu Arg Ala Ser Asn Leu Glu Leu Glu Val Ala Leu Leu 
            420                 425                 430         


Glu Gly Leu Tyr Ala Leu Ala Gly Leu Tyr Pro Arg Ala Ser Pro Ile 
        435                 440                 445             


Leu Glu Pro His Glu Leu Tyr Ser Ala Leu Ala Thr Tyr Arg Cys Tyr 
    450                 455                 460                 


Ser Thr His Arg Pro Arg Leu Glu Val Ala Leu Ala Arg Gly Pro His 
465                 470                 475                 480 


Glu Ala Ser Asn Leu Tyr Ser Ser Glu Arg Ala Ser Pro Leu Tyr Ser 
                485                 490                 495     


Leu Glu Ile Leu Glu Gly Leu Pro Arg Ser Glu Arg Ala Ser Asn His 
            500                 505                 510         


Ile Ser Gly Leu Tyr Pro His Glu Gly Leu Tyr Ser Glu Arg Ile Leu 
        515                 520                 525             


Glu Ala Ser Asn Ile Leu Glu Leu Glu Thr His Arg Pro His Glu Ser 
    530                 535                 540                 


Glu Arg Pro Arg Gly Leu Thr Tyr Arg Gly Leu His Ile Ser Ile Leu 
545                 550                 555                 560 


Glu Pro His Glu Ala Ser Asn Ala Ser Pro Ile Leu Glu Ser Glu Arg 
                565                 570                 575     


Gly Leu Tyr Gly Leu Tyr Ala Ser Asn His Ile Ser Ala Ser Asn Ser 
            580                 585                 590         


Glu Arg Thr His Arg Gly Leu Ser Glu Arg Pro His Glu Ile Leu Glu 
        595                 600                 605             


Ala Leu Ala Ala Ser Pro Pro Arg Ala Leu Ala Ile Leu Glu Ser Glu 
    610                 615                 620                 


Arg Leu Glu Ala Leu Ala His Ile Ser Gly Leu Leu Glu Ile Leu Glu 
625                 630                 635                 640 


His Ile Ser Ala Leu Ala Leu Glu His Ile Ser Gly Leu Tyr Leu Glu 
                645                 650                 655     


Thr Tyr Arg Gly Leu Tyr Ala Leu Ala Leu Tyr Ser Ala Leu Ala Val 
            660                 665                 670         


Ala Leu Thr His Arg His Ile Ser Leu Tyr Ser Gly Leu Ser Glu Arg 
        675                 680                 685             


Leu Glu Val Ala Leu Ala Leu Ala Gly Leu Ala Arg Gly Gly Leu Tyr 
    690                 695                 700                 


Pro Arg Leu Glu Met Glu Thr Ile Leu Glu Ala Leu Ala Gly Leu Leu 
705                 710                 715                 720 


Tyr Ser Pro Arg Ile Leu Glu Ala Arg Gly Leu Glu Gly Leu Gly Leu 
                725                 730                 735     


Pro His Glu Leu Glu Thr His Arg Pro His Glu Gly Leu Tyr Gly Leu 
            740                 745                 750         


Tyr Gly Leu Ala Ser Pro Leu Glu Ala Ser Asn Ile Leu Glu Ile Leu 
        755                 760                 765             


Glu Pro Arg Ser Glu Arg Ala Leu Ala Met Glu Thr Leu Tyr Ser Gly 
    770                 775                 780                 


Leu Leu Tyr Ser Ile Leu Glu Thr Tyr Arg Ala Ser Asn Ala Ser Pro 
785                 790                 795                 800 


Leu Glu Leu Glu Ala Leu Ala Ala Ser Asn Thr Tyr Arg Gly Leu Leu 
                805                 810                 815     


Tyr Ser Ile Leu Glu Ala Leu Ala Thr His Arg Ala Arg Gly Leu Glu 
            820                 825                 830         


Ala Arg Gly Gly Leu Val Ala Leu Ala Ser Asn Thr His Arg Ala Leu 
        835                 840                 845             


Ala Pro Arg Pro Arg Gly Leu Tyr Thr Tyr Arg Ala Ser Pro Ile Leu 
    850                 855                 860                 


Glu Ala Ser Asn Gly Leu Thr Tyr Arg Leu Tyr Ser Ala Ser Pro Thr 
865                 870                 875                 880 


Tyr Arg Pro His Glu Gly Leu Asn Thr Arg Pro Leu Tyr Ser Thr Tyr 
                885                 890                 895     


Arg Gly Leu Tyr Leu Glu Ala Ser Pro Ala Arg Gly Ala Ser Asn Ala 
            900                 905                 910         


Leu Ala Ala Ser Pro Gly Leu Tyr Ser Glu Arg Thr Tyr Arg Thr His 
        915                 920                 925             


Arg Val Ala Leu Ala Ser Asn Ala Arg Gly Ala Ser Asn Leu Tyr Ser 
    930                 935                 940                 


Pro His Glu Ala Ser Asn Gly Leu Ile Leu Glu Thr Tyr Arg Leu Tyr 
945                 950                 955                 960 


Ser Leu Tyr Ser Leu Glu Thr Tyr Arg Ser Glu Arg Pro His Glu Thr 
                965                 970                 975     


His Arg Gly Leu Ile Leu Glu Ala Ser Pro Leu Glu Ala Leu Ala Ala 
            980                 985                 990         


Ser Asn Leu Tyr Ser Pro His Glu  Leu Tyr Ser Val Ala  Leu Leu Tyr 
        995                 1000                 1005             


Ser Cys  Tyr Ser Ala Arg Gly  Ala Ser Asn Thr His  Arg Thr Tyr 
    1010                 1015                 1020             


Arg Pro  His Glu Ile Leu Glu  Leu Tyr Ser Thr Tyr  Arg Gly Leu 
    1025                 1030                 1035             


Tyr Pro  His Glu Val Ala Leu  Leu Tyr Ser Val Ala  Leu Pro Arg 
    1040                 1045                 1050             


Ala Ser  Asn Leu Glu Leu Glu  Ala Ser Pro Ala Ser  Pro Ala Ser 
    1055                 1060                 1065             


Pro Ile  Leu Glu Thr Tyr Arg  Thr His Arg Val Ala  Leu Ser Glu 
    1070                 1075                 1080             


Arg Gly  Leu Gly Leu Tyr Pro  His Glu Ala Ser Asn  Ile Leu Glu 
    1085                 1090                 1095             


Gly Leu  Tyr Ala Ser Asn Leu  Glu Ala Leu Ala Val  Ala Leu Ala 
    1100                 1105                 1110             


Ser Asn  Ala Ser Asn Ala Arg  Gly Gly Leu Tyr Gly  Leu Asn Ala 
    1115                 1120                 1125             


Ser Asn  Ile Leu Glu Ala Ser  Asn Leu Glu Ala Ser  Asn Pro Arg 
    1130                 1135                 1140             


Leu Tyr  Ser Ile Leu Glu Ile  Leu Glu Ala Ser Pro  Ser Glu Arg 
    1145                 1150                 1155             


Ile Leu  Glu Pro Arg Ala Ser  Pro Leu Tyr Ser Gly  Leu Tyr Leu 
    1160                 1165                 1170             


Glu Val  Ala Leu Gly Leu Leu  Tyr Ser Ile Leu Glu  Ile Leu Glu 
    1175                 1180                 1185             


Leu Tyr  Ser Pro His Glu Cys  Tyr Ser Leu Tyr Ser  Ser Glu Arg 
    1190                 1195                 1200             


Ile Leu  Glu Ile Leu Glu Pro  Arg Ala Arg Gly Leu  Tyr Ser Gly 
    1205                 1210                 1215             


Leu Tyr  Thr His Arg Leu Tyr  Ser Gly Leu Asn Ser  Glu Arg Pro 
    1220                 1225                 1230             


Arg Ser  Glu Arg Leu Glu Cys  Tyr Ser Ile Leu Glu  Ala Arg Gly 
    1235                 1240                 1245             


Val Ala  Leu Ala Ser Asn Ala  Ser Asn Ala Arg Gly  Gly Leu Leu 
    1250                 1255                 1260             


Glu Pro  His Glu Pro His Glu  Val Ala Leu Ala Leu  Ala Ser Glu 
    1265                 1270                 1275             


Arg Gly  Leu Ser Glu Arg Ser  Glu Arg Thr Tyr Arg  Ala Ser Asn 
    1280                 1285                 1290             


Gly Leu  Ser Glu Arg Ala Ser  Pro Ile Leu Glu Ala  Ser Asn Thr 
    1295                 1300                 1305             


His Arg  Pro Arg Leu Tyr Ser  Gly Leu Ile Leu Glu  Ala Ser Pro 
    1310                 1315                 1320             


Ala Ser  Pro Thr His Arg Thr  His Arg Ala Ser Asn  Leu Glu Ala 
    1325                 1330                 1335             


Ser Asn  Ala Ser Asn Ala Ser  Asn Thr Tyr Arg Ala  Arg Gly Ala 
    1340                 1345                 1350             


Ser Asn  Ala Ser Asn Leu Glu  Ala Ser Pro Gly Leu  Val Ala Leu 
    1355                 1360                 1365             


Ile Leu  Glu Leu Glu Ala Ser  Pro Thr Tyr Arg Ala  Ser Asn Ser 
    1370                 1375                 1380             


Glu Arg  Gly Leu Thr His Arg  Ile Leu Glu Pro Arg  Gly Leu Asn 
    1385                 1390                 1395             


Ile Leu  Glu Ser Glu Arg Ala  Ser Asn Ala Arg Gly  Thr His Arg 
    1400                 1405                 1410             


Leu Glu  Ala Ser Asn Thr His  Arg Leu Glu Val Ala  Leu Gly Leu 
    1415                 1420                 1425             


Asn Ala  Ser Pro Ala Ser Asn  Ser Glu Arg Thr Tyr  Arg Val Ala 
    1430                 1435                 1440             


Leu Pro  Arg Ala Arg Gly Thr  Tyr Arg Ala Ser Pro  Ser Glu Arg 
    1445                 1450                 1455             


Ala Ser  Asn Gly Leu Tyr Thr  His Arg Ser Glu Arg  Gly Leu Ile 
    1460                 1465                 1470             


Leu Glu  Gly Leu Gly Leu Thr  Tyr Arg Ala Ser Pro  Val Ala Leu 
    1475                 1480                 1485             


Val Ala  Leu Ala Ser Pro Pro  His Glu Ala Ser Asn  Val Ala Leu 
    1490                 1495                 1500             


Pro His  Glu Pro His Glu Thr  Tyr Arg Leu Glu His  Ile Ser Ala 
    1505                 1510                 1515             


Leu Ala  Gly Leu Asn Leu Tyr  Ser Val Ala Leu Pro  Arg Gly Leu 
    1520                 1525                 1530             


Gly Leu  Tyr Gly Leu Thr His  Arg Ala Ser Asn Ile  Leu Glu Ser 
    1535                 1540                 1545             


Glu Arg  Leu Glu Thr His Arg  Ser Glu Arg Ser Glu  Arg Ile Leu 
    1550                 1555                 1560             


Glu Ala  Ser Pro Thr His Arg  Ala Leu Ala Leu Glu  Leu Glu Gly 
    1565                 1570                 1575             


Leu Gly  Leu Ser Glu Arg Leu  Tyr Ser Val Ala Leu  Thr Tyr Arg 
    1580                 1585                 1590             


Thr His  Arg Pro His Glu Pro  His Glu Ser Glu Arg  Ser Glu Arg 
    1595                 1600                 1605             


Gly Leu  Pro His Glu Ile Leu  Glu Ala Ser Pro Thr  His Arg Ile 
    1610                 1615                 1620             


Leu Glu  Ala Ser Asn Leu Tyr  Ser Pro Arg Val Ala  Leu Ala Ser 
    1625                 1630                 1635             


Asn Ala  Leu Ala Ala Leu Ala  Leu Glu Pro His Glu  Ile Leu Glu 
    1640                 1645                 1650             


Ala Ser  Pro Thr Arg Pro Ile  Leu Glu Ser Glu Arg  Leu Tyr Ser 
    1655                 1660                 1665             


Val Ala  Leu Ile Leu Glu Ala  Arg Gly Ala Ser Pro  Pro His Glu 
    1670                 1675                 1680             


Thr His  Arg Thr His Arg Gly  Leu Ala Leu Ala Thr  His Arg Gly 
    1685                 1690                 1695             


Leu Asn  Leu Tyr Ser Ser Glu  Arg Thr His Arg Val  Ala Leu Ala 
    1700                 1705                 1710             


Ser Pro  Leu Tyr Ser Ile Leu  Glu Ala Leu Ala Ala  Ser Pro Ile 
    1715                 1720                 1725             


Leu Glu  Ser Glu Arg Leu Glu  Ile Leu Glu Val Ala  Leu Pro Arg 
    1730                 1735                 1740             


Thr Tyr  Arg Val Ala Leu Gly  Leu Tyr Leu Glu Ala  Leu Ala Leu 
    1745                 1750                 1755             


Glu Ala  Ser Asn Ile Leu Glu  Val Ala Leu Ile Leu  Glu Gly Leu 
    1760                 1765                 1770             


Ala Leu  Ala Gly Leu Leu Tyr  Ser Gly Leu Tyr Ala  Ser Asn Pro 
    1775                 1780                 1785             


His Glu  Gly Leu Gly Leu Ala  Leu Ala Pro His Glu  Gly Leu Leu 
    1790                 1795                 1800             


Glu Leu  Glu Gly Leu Tyr Ala  Leu Ala Gly Leu Tyr  Ile Leu Glu 
    1805                 1810                 1815             


Leu Glu  Leu Glu Gly Leu Pro  His Glu Val Ala Leu  Pro Arg Gly 
    1820                 1825                 1830             


Leu Leu  Glu Thr His Arg Ile  Leu Glu Pro Arg Val  Ala Leu Ile 
    1835                 1840                 1845             


Leu Glu  Leu Glu Val Ala Leu  Pro His Glu Thr His  Arg Ile Leu 
    1850                 1855                 1860             


Glu Leu  Tyr Ser Ser Glu Arg  Thr Tyr Arg Ile Leu  Glu Ala Ser 
    1865                 1870                 1875             


Pro Ser  Glu Arg Thr Tyr Arg  Gly Leu Ala Ser Asn  Leu Tyr Ser 
    1880                 1885                 1890             


Ala Ser  Asn Leu Tyr Ser Ala  Leu Ala Ile Leu Glu  Leu Tyr Ser 
    1895                 1900                 1905             


Ala Leu  Ala Ile Leu Glu Ala  Ser Asn Ala Ser Asn  Ser Glu Arg 
    1910                 1915                 1920             


Leu Glu  Ile Leu Glu Gly Leu  Ala Arg Gly Gly Leu  Ala Leu Ala 
    1925                 1930                 1935             


Leu Tyr  Ser Thr Arg Pro Leu  Tyr Ser Gly Leu Ile  Leu Glu Thr 
    1940                 1945                 1950             


Tyr Arg  Ser Glu Arg Thr Arg  Pro Ile Leu Glu Val  Ala Leu Ser 
    1955                 1960                 1965             


Glu Arg  Ala Ser Asn Thr Arg  Pro Leu Glu Thr His  Arg Ala Arg 
    1970                 1975                 1980             


Gly Ile  Leu Glu Ala Ser Asn  Thr His Arg Gly Leu  Asn Pro His 
    1985                 1990                 1995             


Glu Ala  Ser Asn Leu Tyr Ser  Ala Arg Gly Leu Tyr  Ser Gly Leu 
    2000                 2005                 2010             


Gly Leu  Asn Met Glu Thr Thr  Tyr Arg Gly Leu Asn  Ala Leu Ala 
    2015                 2020                 2025             


Leu Glu  Gly Leu Asn Ala Ser  Asn Gly Leu Asn Val  Ala Leu Ala 
    2030                 2035                 2040             


Ser Pro  Ala Leu Ala Ile Leu  Glu Leu Tyr Ser Thr  His Arg Ala 
    2045                 2050                 2055             


Leu Ala  Ile Leu Glu Gly Leu  Thr Tyr Arg Leu Tyr  Ser Thr Tyr 
    2060                 2065                 2070             


Arg Ala  Ser Asn Ala Ser Asn  Thr Tyr Arg Thr His  Arg Ser Glu 
    2075                 2080                 2085             


Arg Ala  Ser Pro Gly Leu Leu  Tyr Ser Ala Ser Asn  Ala Arg Gly 
    2090                 2095                 2100             


Leu Glu  Gly Leu Ser Glu Arg  Leu Tyr Ser Thr Tyr  Arg Ala Ser 
    2105                 2110                 2115             


Asn Ile  Leu Glu Ala Ser Asn  Ala Ser Asn Ile Leu  Glu Gly Leu 
    2120                 2125                 2130             


Gly Leu  Gly Leu Leu Glu Ala  Ser Asn Leu Tyr Ser  Leu Tyr Ser 
    2135                 2140                 2145             


Val Ala  Leu Ser Glu Arg Leu  Glu Ala Leu Ala Met  Glu Thr Leu 
    2150                 2155                 2160             


Tyr Ser  Ala Ser Asn Ile Leu  Glu Gly Leu Ala Arg  Gly Pro His 
    2165                 2170                 2175             


Glu Met  Glu Thr Thr His Arg  Gly Leu Ser Glu Arg  Ser Glu Arg 
    2180                 2185                 2190             


Ile Leu  Glu Ser Glu Arg Thr  Tyr Arg Leu Glu Met  Glu Thr Leu 
    2195                 2200                 2205             


Tyr Ser  Leu Glu Ile Leu Glu  Ala Ser Asn Gly Leu  Ala Leu Ala 
    2210                 2215                 2220             


Gly Leu  Val Ala Leu Gly Leu  Tyr Leu Tyr Ser Leu  Glu Leu Tyr 
    2225                 2230                 2235             


Ser Gly  Leu Thr Tyr Arg Ala  Ser Pro Leu Tyr Ser  His Ile Ser 
    2240                 2245                 2250             


Val Ala  Leu Leu Tyr Ser Ser  Glu Arg Ala Ser Pro  Leu Glu Leu 
    2255                 2260                 2265             


Glu Ala  Ser Pro Thr Tyr Arg  Ile Leu Glu Leu Glu  Thr Tyr Arg 
    2270                 2275                 2280             


His Ile  Ser Leu Tyr Ser Leu  Glu Ile Leu Glu Leu  Glu Gly Leu 
    2285                 2290                 2295             


Tyr Gly  Leu Gly Leu Asn Thr  His Arg Leu Tyr Ser  Gly Leu Leu 
    2300                 2305                 2310             


Glu Ile  Leu Glu Ala Ser Pro  Leu Glu Val Ala Leu  Thr His Arg 
    2315                 2320                 2325             


Ser Glu  Arg Thr His Arg Leu  Glu Ala Ser Asn Ser  Glu Arg Ser 
    2330                 2335                 2340             


Glu Arg  Ile Leu Glu Pro Arg  Pro His Glu Gly Leu  Leu Glu Ser 
    2345                 2350                 2355             


Glu Arg  Ser Glu Arg Thr Tyr  Arg Thr His Arg Ala  Ser Asn Ala 
    2360                 2365                 2370             


Ser Pro  Leu Tyr Ser Ile Leu  Glu Leu Glu Ile Leu  Glu Ile Leu 
    2375                 2380                 2385             


Glu Thr  Tyr Arg Pro His Glu  Ala Ser Asn Ala Arg  Gly Leu Glu 
    2390                 2395                 2400             


Thr Tyr  Arg Leu Tyr Ser Leu  Tyr Ser Ile Leu Glu  Leu Tyr Ser 
    2405                 2410                 2415             


Ala Ser  Pro Ser Glu Arg Ser  Glu Arg Ile Leu Glu  Leu Glu Ala 
    2420                 2425                 2430             


Ser Pro  Met Glu Thr Ala Arg  Gly Thr Tyr Arg Gly  Leu Ala Ser 
    2435                 2440                 2445             


Asn Ala  Ser Asn Leu Tyr Ser  Pro His Glu Ile Leu  Glu Ala Ser 
    2450                 2455                 2460             


Pro Ile  Leu Glu Ser Glu Arg  Gly Leu Tyr Thr Tyr  Arg Gly Leu 
    2465                 2470                 2475             


Tyr Ser  Glu Arg Ala Ser Asn  Ile Leu Glu Ser Glu  Arg Ile Leu 
    2480                 2485                 2490             


Glu Ala  Ser Asn Gly Leu Tyr  Ala Ser Asn Val Ala  Leu Thr Tyr 
    2495                 2500                 2505             


Arg Ile  Leu Glu Thr Tyr Arg  Ser Glu Arg Thr His  Arg Ala Ser 
    2510                 2515                 2520             


Asn Ala  Arg Gly Ala Ser Asn  Gly Leu Asn Pro His  Glu Gly Leu 
    2525                 2530                 2535             


Tyr Ile  Leu Glu Thr Tyr Arg  Ser Glu Arg Gly Leu  Tyr Ala Arg 
    2540                 2545                 2550             


Gly Leu  Glu Ser Glu Arg Gly  Leu Val Ala Leu Ala  Ser Asn Ile 
    2555                 2560                 2565             


Leu Glu  Ala Leu Ala Gly Leu  Asn Ala Ser Asn Ala  Ser Asn Ala 
    2570                 2575                 2580             


Ser Pro  Ile Leu Glu Ile Leu  Glu Thr Tyr Arg Ala  Ser Asn Ser 
    2585                 2590                 2595             


Glu Arg  Ala Arg Gly Thr Tyr  Arg Gly Leu Asn Ala  Ser Asn Pro 
    2600                 2605                 2610             


His Glu  Ser Glu Arg Ile Leu  Glu Ser Glu Arg Pro  His Glu Thr 
    2615                 2620                 2625             


Arg Pro  Val Ala Leu Thr His  Arg Ile Leu Glu Pro  Arg Leu Tyr 
    2630                 2635                 2640             


Ser His  Ile Ser Thr Tyr Arg  Ala Arg Gly Pro Arg  Met Glu Thr 
    2645                 2650                 2655             


Ala Ser  Asn Ala Arg Gly Ala  Ser Asn Ala Arg Gly  Gly Leu Thr 
    2660                 2665                 2670             


Tyr Arg  Thr His Arg Ile Leu  Glu Ile Leu Glu Ala  Ser Asn Cys 
    2675                 2680                 2685             


Tyr Ser  Met Glu Thr Gly Leu  Tyr Ala Ser Asn Ala  Ser Asn Ala 
    2690                 2695                 2700             


Ser Asn  Ser Glu Arg Gly Leu  Tyr Thr Arg Pro Leu  Tyr Ser Ile 
    2705                 2710                 2715             


Leu Glu  Ser Glu Arg Leu Glu  Ala Arg Gly Thr His  Arg Ile Leu 
    2720                 2725                 2730             


Glu Ala  Arg Gly Ala Ser Pro  Cys Tyr Ser Gly Leu  Ile Leu Glu 
    2735                 2740                 2745             


Ile Leu  Glu Thr Arg Pro Thr  His Arg Leu Glu Gly  Leu Asn Ala 
    2750                 2755                 2760             


Ser Pro  Thr His Arg Ser Glu  Arg Gly Leu Tyr Ala  Ser Asn Leu 
    2765                 2770                 2775             


Tyr Ser  Gly Leu Leu Tyr Ser  Leu Glu Ile Leu Glu  Pro His Glu 
    2780                 2785                 2790             


Ala Arg  Gly Thr Tyr Arg Gly  Leu Gly Leu Leu Glu  Ala Leu Ala 
    2795                 2800                 2805             


Ser Glu  Arg Ile Leu Glu Ser  Glu Arg Ala Ser Pro  Thr Tyr Arg 
    2810                 2815                 2820             


Ile Leu  Glu Ala Ser Asn Leu  Tyr Ser Thr Arg Pro  Ile Leu Glu 
    2825                 2830                 2835             


Pro His  Glu Val Ala Leu Thr  His Arg Ile Leu Glu  Thr His Arg 
    2840                 2845                 2850             


Ala Ser  Asn Ala Ser Asn Ala  Arg Gly Leu Glu Gly  Leu Tyr Ala 
    2855                 2860                 2865             


Ser Asn  Ser Glu Arg Ala Arg  Gly Ile Leu Glu Thr  Tyr Arg Ile 
    2870                 2875                 2880             


Leu Glu  Ala Ser Asn Gly Leu  Tyr Ala Ser Asn Leu  Glu Ile Leu 
    2885                 2890                 2895             


Glu Val  Ala Leu Gly Leu Leu  Tyr Ser Ser Glu Arg  Ile Leu Glu 
    2900                 2905                 2910             


Ser Glu  Arg Ala Ser Asn Leu  Glu Gly Leu Tyr Ala  Ser Pro Ile 
    2915                 2920                 2925             


Leu Glu  His Ile Ser Val Ala  Leu Ser Glu Arg Ala  Ser Pro Ala 
    2930                 2935                 2940             


Ser Asn  Ile Leu Glu Leu Glu  Pro His Glu Leu Tyr  Ser Ile Leu 
    2945                 2950                 2955             


Glu Val  Ala Leu Gly Leu Tyr  Cys Tyr Ser Ala Ser  Pro Ala Ser 
    2960                 2965                 2970             


Pro Gly  Leu Thr His Arg Thr  Tyr Arg Val Ala Leu  Gly Leu Tyr 
    2975                 2980                 2985             


Ile Leu  Glu Ala Arg Gly Thr  Tyr Arg Pro His Glu  Leu Tyr Ser 
    2990                 2995                 3000             


Val Ala  Leu Pro His Glu Ala  Ser Asn Thr His Arg  Gly Leu Leu 
    3005                 3010                 3015             


Glu Ala  Ser Pro Leu Tyr Ser  Thr His Arg Gly Leu  Ile Leu Glu 
    3020                 3025                 3030             


Gly Leu  Thr His Arg Leu Glu  Thr Tyr Arg Ser Glu  Arg Ala Ser 
    3035                 3040                 3045             


Asn Gly  Leu Pro Arg Ala Ser  Pro Pro Arg Ser Glu  Arg Ile Leu 
    3050                 3055                 3060             


Glu Leu  Glu Leu Tyr Ser Ala  Ser Pro Thr Tyr Arg  Thr Arg Pro 
    3065                 3070                 3075             


Gly Leu  Tyr Ala Ser Asn Thr  Tyr Arg Leu Glu Leu  Glu Thr Tyr 
    3080                 3085                 3090             


Arg Ala  Ser Asn Leu Tyr Ser  Leu Tyr Ser Thr Tyr  Arg Thr Tyr 
    3095                 3100                 3105             


Arg Leu  Glu Pro His Glu Ala  Ser Asn Leu Glu Leu  Glu Ala Arg 
    3110                 3115                 3120             


Gly Leu  Tyr Ser Ala Ser Pro  Leu Tyr Ser Thr Tyr  Arg Ile Leu 
    3125                 3130                 3135             


Glu Thr  His Arg Ala Arg Gly  Ala Ser Asn Ser Glu  Arg Gly Leu 
    3140                 3145                 3150             


Tyr Ile  Leu Glu Leu Glu Ala  Ser Asn Ile Leu Glu  Ala Ser Asn 
    3155                 3160                 3165             


Gly Leu  Asn Gly Leu Asn Ala  Arg Gly Gly Leu Tyr  Val Ala Leu 
    3170                 3175                 3180             


Thr His  Arg Gly Leu Tyr Gly  Leu Tyr Ile Leu Glu  Ser Glu Arg 
    3185                 3190                 3195             


Val Ala  Leu Pro His Glu Leu  Glu Ala Ser Asn Thr  Tyr Arg Leu 
    3200                 3205                 3210             


Tyr Ser  Leu Glu Thr Tyr Arg  Gly Leu Gly Leu Tyr  Val Ala Leu 
    3215                 3220                 3225             


Gly Leu  Val Ala Leu Ile Leu  Glu Ile Leu Glu Ala  Arg Gly Leu 
    3230                 3235                 3240             


Tyr Ser  Ala Ser Asn Ala Leu  Ala Pro Arg Ile Leu  Glu Ala Ser 
    3245                 3250                 3255             


Pro Ile  Leu Glu Ser Glu Arg  Ala Ser Asn Thr His  Arg Ala Ser 
    3260                 3265                 3270             


Pro Ala  Ser Asn Pro His Glu  Val Ala Leu Ala Arg  Gly Leu Tyr 
    3275                 3280                 3285             


Ser Ala  Ser Asn Ala Ser Pro  Leu Glu Ala Leu Ala  Thr Tyr Arg 
    3290                 3295                 3300             


Ile Leu  Glu Ala Ser Asn Val  Ala Leu Val Ala Leu  Ala Ser Pro 
    3305                 3310                 3315             


His Ile  Ser Gly Leu Tyr Val  Ala Leu Gly Leu Thr  Tyr Arg Ala 
    3320                 3325                 3330             


Arg Gly  Leu Glu Thr Tyr Arg  Ala Leu Ala Ala Ser  Pro Ile Leu 
    3335                 3340                 3345             


Glu Ser  Glu Arg Ile Leu Glu  Thr His Arg Leu Tyr  Ser Ser Glu 
    3350                 3355                 3360             


Arg Gly  Leu Leu Tyr Ser Ile  Leu Glu Ile Leu Glu  Leu Tyr Ser 
    3365                 3370                 3375             


Leu Glu  Ile Leu Glu Ala Arg  Gly Thr His Arg Ser  Glu Arg Ala 
    3380                 3385                 3390             


Ser Asn  Pro Arg Ala Ser Asn  Ala Ser Pro Ser Glu  Arg Leu Glu 
    3395                 3400                 3405             


Gly Leu  Tyr Gly Leu Asn Ile  Leu Glu Ile Leu Glu  Val Ala Leu 
    3410                 3415                 3420             


Met Glu  Thr Ala Ser Pro Ser  Glu Arg Ile Leu Glu  Gly Leu Tyr 
    3425                 3430                 3435             


Ala Ser  Asn Ala Ser Asn Cys  Tyr Ser Thr His Arg  Met Glu Thr 
    3440                 3445                 3450             


Ala Ser  Asn Pro His Glu Gly  Leu Asn Ala Ser Asn  Ala Ser Asn 
    3455                 3460                 3465             


Ala Ser  Pro Gly Leu Tyr Ser  Glu Arg Ala Ser Asn  Ile Leu Glu 
    3470                 3475                 3480             


Gly Leu  Tyr Leu Glu Leu Glu  Gly Leu Tyr Pro His  Glu His Ile 
    3485                 3490                 3495             


Ser Ser  Glu Arg Ala Ser Pro  Ala Ser Pro Leu Glu  Val Ala Leu 
    3500                 3505                 3510             


Ala Leu  Ala Ser Glu Arg Ser  Glu Arg Thr Arg Pro  Thr Tyr Arg 
    3515                 3520                 3525             


Thr Tyr  Arg Ala Ser Asn His  Ile Ser Ile Leu Glu  Ala Arg Gly 
    3530                 3535                 3540             


Ala Arg  Gly Ala Ser Asn Thr  His Arg Ser Glu Arg  Ser Glu Arg 
    3545                 3550                 3555             


Ala Ser  Asn Gly Leu Tyr Cys  Tyr Ser Pro His Glu  Thr Arg Pro 
    3560                 3565                 3570             


Ser Glu  Arg Pro His Glu Ile  Leu Glu Ser Glu Arg  Leu Tyr Ser 
    3575                 3580                 3585             


Gly Leu  His Ile Ser Gly Leu  Tyr Thr Arg Pro Leu  Tyr Ser Gly 
    3590                 3595                 3600             


Leu 
    


<210>  13
<211>  3894
<212>  DNA
<213>  Clostridium botulinum


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is a, c, g, or t

<400>  13
atgccagtta atataaaaan ctttaattat aatgacccta ttaataatga tgacattatt       60

atgatggaac cattcaatga cccagggcca ggaacatatt ataaagcttt taggattata      120

gatcgtattt ggatagtacc agaaaggttt acttatggat ttcaacctga ccaatttaat      180

gccagtacag gagtttttag taaagatgtc tacgaatatt acgatccaac ttatttaaaa      240

accgatgctg aaaaagataa atttttaaaa acaatgatta aattatttaa tagaattaat      300

tcaaaaccat caggacagag attactggat atgatagtag atgctatacc ttatcttgga      360

aatgcatcta caccgcccga caaatttgca gcaaatgttg caaatgtatc tattaataaa      420

aaaattatcc aacctggagc tgaagatcaa ataaaaggtt taatgacaaa tttaataata      480

tttggaccag gaccagttct aagtgataat tttactgata gtatgattat gaatggccat      540

tccccaatat cagaaggatt tggtgcaaga atgatgataa gattttgtcc tagttgttta      600

aatgtattta ataatgttca ggaaaataaa gatacatcta tatttagtag acgcgcgtat      660

tttgcagatc cagctctaac gttaatgcat gaacttatac atgtgttaca tggattatat      720

ggaattaaga taagtaattt accaattact ccaaatacaa aagaattttt catgcaacat      780

agcgatcctg tacaagcaga agaactatat acattcggag gacatgatcc tagtgttata      840

agtccttcta cggatatgaa tatttataat aaagcgttac aaaattttca agatatagct      900

aataggctta atattgtttc aagtgcccaa gggagtggaa ttgatatttc cttatataaa      960

caaatatata aaaataaata tgattttgtt gaagatccta atggaaaata tagtgtagat     1020

aaggataagt ttgataaatt atataaggcc ttaatgtttg gctttactga aactaatcta     1080

gctggtgaat atggaataaa aactaggtat tcttatttta gtgaatattt gccaccgata     1140

aaaactgaaa aattgttaga caatacaatt tatactcaaa atgaaggctt taacatagct     1200

agtaaaaatc tcaaaacgga atttaatggt cagaataagg cggtaaataa agaggcttat     1260

gaagaaatca gcctagaaca tctcgttata tatagaatag caatgtgcaa gcctgtaatg     1320

tacaaaaata ccggtaaatc tgaacagtgt attattgtta ataatgagga tttatttttc     1380

atagctaata aagatagttt ttcaaaagat ttagctaaag cagaaactat agcatataat     1440

acacaaaata atactataga aaataatttt tctatagatc agttgatttt agataatgat     1500

ttaagcagtg gcatagactt accaaatgaa aacacagaac catttacaaa ttttgacgac     1560

atagatatcc ctgtgtatat taaacaatct gctttaaaaa aaatttttgt ggatggagat     1620

agcctttttg aatatttaca tgctcaaaca tttccttcta atatagaaaa tctacaacta     1680

acgaattcat taaatgatgc tttaagaaat aataataaag tctatacttt tttttctaca     1740

aaccttgttg aaaaagctaa tacagttgta ggtgcttcac tttttgtaaa ctgggtaaaa     1800

ggagtaatag atgattttac atctgaatcc acacaaaaaa gtactataga taaagtttca     1860

gatgtatcca taattattcc ctatatagga cctgctttga atgtaggaaa tgaaacagct     1920

aaagaaaatt ttaaaaatgc ttttgaaata ggtggagccg ctatcttaat ggagtttatt     1980

ccagaactta ttgtacctat agttggattt tttacattag aatcatatgt aggaaataaa     2040

gggcatatta ttatgacgat atccaatgct ttaaagaaaa gggatcaaaa atggacagat     2100

atgtatggtt tgatagtatc gcagtggctc tcaacggtta atactcaatt ttatacaata     2160

aaagaaagaa tgtacaatgc tttaaataat caatcacaag caatagaaaa aataatagaa     2220

gatcaatata atagatatag tgaagaagat aaaatgaata ttaacattga ttttaatgat     2280

atagatttta aacttaatca aagtataaat ttagcaataa acaatataga tgattttata     2340

aaccaatgtt ctatatcata tctaatgaat agaatgattc cattagctgt aaaaaagtta     2400

aaagactttg atgataatct taagagagat ttattggagt atatagatac aaatgaacta     2460

tatttacttg atgaagtaaa tattctaaaa tcaaaagtaa atagacacct aaaagacagt     2520

ataccatttg atctttcact atataccaag gacacaattt taatacaagt ttttaataat     2580

tatattagta atattagtag taatgctatt ttaagtttaa gttatagagg tgggcgttta     2640

atagattcat ctggatatgg tgcaactatg aatgtaggtt cagatgttat ctttaatgat     2700

ataggaaatg gtcaatttaa attaaataat tctgaaaata gtaatattac ggcacatcaa     2760

agtaaattcg ttgtatatga tagtatgttt gataatttta gcattaactt ttgggtaagg     2820

actcctaaat ataataataa tgatatacaa acttatcttc aaaatgagta tacaataatt     2880

agttgtataa aaaatgactc aggatggaaa gtatctatta agggaaatag aataatatgg     2940

acattaatag atgttaatgc aaaatctaaa tcaatatttt tcgaatatag tataaaagat     3000

aatatatcag attatataaa taaatggttt tccataacta ttactaatga tagattaggt     3060

aacgcaaata tttatataaa tggaagtttg aaaaaaagtg aaaaaatttt aaacttagat     3120

agaattaatt ctagtaatga tatagacttc aaattaatta attgtacaga tactactaaa     3180

tttgtttgga ttaaggattt taatattttt ggtagagaat taaatgctac agaagtatct     3240

tcactatatt ggattcaatc atctacaaat actttaaaag atttttgggg gaatccttta     3300

agatacgata cacaatacta tctgtttaat caaggtatgc aaaatatcta tataaagtat     3360

tttagtaaag cttctatggg ggaaactgca ccacgtacaa actttaataa tgcagcaata     3420

aattatcaaa atttatatct tggtttacga tttattataa aaaaagcatc aaattctcgg     3480

aatataaata atgataatat agtcagagaa ggagattata tatatcttaa tattgataat     3540

atttctgatg aatcttacag agtatatgtt ttggtgaatt ctaaagaaat tcaaactcaa     3600

ttatttttag cacccataaa tgatgatcct acgttctatg atgtactaca aataaaaaaa     3660

tattatgaaa aaacaacata taattgtcag atactttgcg aaaaagatac taaaacattt     3720

gggctgtttg gaattggtaa atttgttaaa gattatggat atgtttggga tacctatgat     3780

aattattttt gcataagtca gtggtatctc agaagaatat ctgaaaatat aaataaatta     3840

aggttgggat gtaattggca attcattccc gtggatgaag gatggacaga ataa           3894


<210>  14
<211>  3690
<212>  PRT
<213>  Clostridium botulinum


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Met Glu Thr Pro Arg Val Ala Leu Ala Ser Asn Ile Leu Glu Leu Tyr 
1               5                   10                  15      


Ser Xaa Ala Ala Pro His Glu Ala Ser Asn Thr Tyr Arg Ala Ser Asn 
            20                  25                  30          


Ala Ser Pro Pro Arg Ile Leu Glu Ala Ser Asn Ala Ser Asn Ala Ser 
        35                  40                  45              


Pro Ala Ser Pro Ile Leu Glu Ile Leu Glu Met Glu Thr Met Glu Thr 
    50                  55                  60                  


Gly Leu Pro Arg Pro His Glu Ala Ser Asn Ala Ser Pro Pro Arg Gly 
65                  70                  75                  80  


Leu Tyr Pro Arg Gly Leu Tyr Thr His Arg Thr Tyr Arg Thr Tyr Arg 
                85                  90                  95      


Leu Tyr Ser Ala Leu Ala Pro His Glu Ala Arg Gly Ile Leu Glu Ile 
            100                 105                 110         


Leu Glu Ala Ser Pro Ala Arg Gly Ile Leu Glu Thr Arg Pro Ile Leu 
        115                 120                 125             


Glu Val Ala Leu Pro Arg Gly Leu Ala Arg Gly Pro His Glu Thr His 
    130                 135                 140                 


Arg Thr Tyr Arg Gly Leu Tyr Pro His Glu Gly Leu Asn Pro Arg Ala 
145                 150                 155                 160 


Ser Pro Gly Leu Asn Pro His Glu Ala Ser Asn Ala Leu Ala Ser Glu 
                165                 170                 175     


Arg Thr His Arg Gly Leu Tyr Val Ala Leu Pro His Glu Ser Glu Arg 
            180                 185                 190         


Leu Tyr Ser Ala Ser Pro Val Ala Leu Thr Tyr Arg Gly Leu Thr Tyr 
        195                 200                 205             


Arg Thr Tyr Arg Ala Ser Pro Pro Arg Thr His Arg Thr Tyr Arg Leu 
    210                 215                 220                 


Glu Leu Tyr Ser Thr His Arg Ala Ser Pro Ala Leu Ala Gly Leu Leu 
225                 230                 235                 240 


Tyr Ser Ala Ser Pro Leu Tyr Ser Pro His Glu Leu Glu Leu Tyr Ser 
                245                 250                 255     


Thr His Arg Met Glu Thr Ile Leu Glu Leu Tyr Ser Leu Glu Pro His 
            260                 265                 270         


Glu Ala Ser Asn Ala Arg Gly Ile Leu Glu Ala Ser Asn Ser Glu Arg 
        275                 280                 285             


Leu Tyr Ser Pro Arg Ser Glu Arg Gly Leu Tyr Gly Leu Asn Ala Arg 
    290                 295                 300                 


Gly Leu Glu Leu Glu Ala Ser Pro Met Glu Thr Ile Leu Glu Val Ala 
305                 310                 315                 320 


Leu Ala Ser Pro Ala Leu Ala Ile Leu Glu Pro Arg Thr Tyr Arg Leu 
                325                 330                 335     


Glu Gly Leu Tyr Ala Ser Asn Ala Leu Ala Ser Glu Arg Thr His Arg 
            340                 345                 350         


Pro Arg Pro Arg Ala Ser Pro Leu Tyr Ser Pro His Glu Ala Leu Ala 
        355                 360                 365             


Ala Leu Ala Ala Ser Asn Val Ala Leu Ala Leu Ala Ala Ser Asn Val 
    370                 375                 380                 


Ala Leu Ser Glu Arg Ile Leu Glu Ala Ser Asn Leu Tyr Ser Leu Tyr 
385                 390                 395                 400 


Ser Ile Leu Glu Ile Leu Glu Gly Leu Asn Pro Arg Gly Leu Tyr Ala 
                405                 410                 415     


Leu Ala Gly Leu Ala Ser Pro Gly Leu Asn Ile Leu Glu Leu Tyr Ser 
            420                 425                 430         


Gly Leu Tyr Leu Glu Met Glu Thr Thr His Arg Ala Ser Asn Leu Glu 
        435                 440                 445             


Ile Leu Glu Ile Leu Glu Pro His Glu Gly Leu Tyr Pro Arg Gly Leu 
    450                 455                 460                 


Tyr Pro Arg Val Ala Leu Leu Glu Ser Glu Arg Ala Ser Pro Ala Ser 
465                 470                 475                 480 


Asn Pro His Glu Thr His Arg Ala Ser Pro Ser Glu Arg Met Glu Thr 
                485                 490                 495     


Ile Leu Glu Met Glu Thr Ala Ser Asn Gly Leu Tyr His Ile Ser Ser 
            500                 505                 510         


Glu Arg Pro Arg Ile Leu Glu Ser Glu Arg Gly Leu Gly Leu Tyr Pro 
        515                 520                 525             


His Glu Gly Leu Tyr Ala Leu Ala Ala Arg Gly Met Glu Thr Met Glu 
    530                 535                 540                 


Thr Ile Leu Glu Ala Arg Gly Pro His Glu Cys Tyr Ser Pro Arg Ser 
545                 550                 555                 560 


Glu Arg Cys Tyr Ser Leu Glu Ala Ser Asn Val Ala Leu Pro His Glu 
                565                 570                 575     


Ala Ser Asn Ala Ser Asn Val Ala Leu Gly Leu Asn Gly Leu Ala Ser 
            580                 585                 590         


Asn Leu Tyr Ser Ala Ser Pro Thr His Arg Ser Glu Arg Ile Leu Glu 
        595                 600                 605             


Pro His Glu Ser Glu Arg Ala Arg Gly Ala Arg Gly Ala Leu Ala Thr 
    610                 615                 620                 


Tyr Arg Pro His Glu Ala Leu Ala Ala Ser Pro Pro Arg Ala Leu Ala 
625                 630                 635                 640 


Leu Glu Thr His Arg Leu Glu Met Glu Thr His Ile Ser Gly Leu Leu 
                645                 650                 655     


Glu Ile Leu Glu His Ile Ser Val Ala Leu Leu Glu His Ile Ser Gly 
            660                 665                 670         


Leu Tyr Leu Glu Thr Tyr Arg Gly Leu Tyr Ile Leu Glu Leu Tyr Ser 
        675                 680                 685             


Ile Leu Glu Ser Glu Arg Ala Ser Asn Leu Glu Pro Arg Ile Leu Glu 
    690                 695                 700                 


Thr His Arg Pro Arg Ala Ser Asn Thr His Arg Leu Tyr Ser Gly Leu 
705                 710                 715                 720 


Pro His Glu Pro His Glu Met Glu Thr Gly Leu Asn His Ile Ser Ser 
                725                 730                 735     


Glu Arg Ala Ser Pro Pro Arg Val Ala Leu Gly Leu Asn Ala Leu Ala 
            740                 745                 750         


Gly Leu Gly Leu Leu Glu Thr Tyr Arg Thr His Arg Pro His Glu Gly 
        755                 760                 765             


Leu Tyr Gly Leu Tyr His Ile Ser Ala Ser Pro Pro Arg Ser Glu Arg 
    770                 775                 780                 


Val Ala Leu Ile Leu Glu Ser Glu Arg Pro Arg Ser Glu Arg Thr His 
785                 790                 795                 800 


Arg Ala Ser Pro Met Glu Thr Ala Ser Asn Ile Leu Glu Thr Tyr Arg 
                805                 810                 815     


Ala Ser Asn Leu Tyr Ser Ala Leu Ala Leu Glu Gly Leu Asn Ala Ser 
            820                 825                 830         


Asn Pro His Glu Gly Leu Asn Ala Ser Pro Ile Leu Glu Ala Leu Ala 
        835                 840                 845             


Ala Ser Asn Ala Arg Gly Leu Glu Ala Ser Asn Ile Leu Glu Val Ala 
    850                 855                 860                 


Leu Ser Glu Arg Ser Glu Arg Ala Leu Ala Gly Leu Asn Gly Leu Tyr 
865                 870                 875                 880 


Ser Glu Arg Gly Leu Tyr Ile Leu Glu Ala Ser Pro Ile Leu Glu Ser 
                885                 890                 895     


Glu Arg Leu Glu Thr Tyr Arg Leu Tyr Ser Gly Leu Asn Ile Leu Glu 
            900                 905                 910         


Thr Tyr Arg Leu Tyr Ser Ala Ser Asn Leu Tyr Ser Thr Tyr Arg Ala 
        915                 920                 925             


Ser Pro Pro His Glu Val Ala Leu Gly Leu Ala Ser Pro Pro Arg Ala 
    930                 935                 940                 


Ser Asn Gly Leu Tyr Leu Tyr Ser Thr Tyr Arg Ser Glu Arg Val Ala 
945                 950                 955                 960 


Leu Ala Ser Pro Leu Tyr Ser Ala Ser Pro Leu Tyr Ser Pro His Glu 
                965                 970                 975     


Ala Ser Pro Leu Tyr Ser Leu Glu Thr Tyr Arg Leu Tyr Ser Ala Leu 
            980                 985                 990         


Ala Leu Glu Met Glu Thr Pro His  Glu Gly Leu Tyr Pro  His Glu Thr 
        995                 1000                 1005             


His Arg  Gly Leu Thr His Arg  Ala Ser Asn Leu Glu  Ala Leu Ala 
    1010                 1015                 1020             


Gly Leu  Tyr Gly Leu Thr Tyr  Arg Gly Leu Tyr Ile  Leu Glu Leu 
    1025                 1030                 1035             


Tyr Ser  Thr His Arg Ala Arg  Gly Thr Tyr Arg Ser  Glu Arg Thr 
    1040                 1045                 1050             


Tyr Arg  Pro His Glu Ser Glu  Arg Gly Leu Thr Tyr  Arg Leu Glu 
    1055                 1060                 1065             


Pro Arg  Pro Arg Ile Leu Glu  Leu Tyr Ser Thr His  Arg Gly Leu 
    1070                 1075                 1080             


Leu Tyr  Ser Leu Glu Leu Glu  Ala Ser Pro Ala Ser  Asn Thr His 
    1085                 1090                 1095             


Arg Ile  Leu Glu Thr Tyr Arg  Thr His Arg Gly Leu  Asn Ala Ser 
    1100                 1105                 1110             


Asn Gly  Leu Gly Leu Tyr Pro  His Glu Ala Ser Asn  Ile Leu Glu 
    1115                 1120                 1125             


Ala Leu  Ala Ser Glu Arg Leu  Tyr Ser Ala Ser Asn  Leu Glu Leu 
    1130                 1135                 1140             


Tyr Ser  Thr His Arg Gly Leu  Pro His Glu Ala Ser  Asn Gly Leu 
    1145                 1150                 1155             


Tyr Gly  Leu Asn Ala Ser Asn  Leu Tyr Ser Ala Leu  Ala Val Ala 
    1160                 1165                 1170             


Leu Ala  Ser Asn Leu Tyr Ser  Gly Leu Ala Leu Ala  Thr Tyr Arg 
    1175                 1180                 1185             


Gly Leu  Gly Leu Ile Leu Glu  Ser Glu Arg Leu Glu  Gly Leu His 
    1190                 1195                 1200             


Ile Ser  Leu Glu Val Ala Leu  Ile Leu Glu Thr Tyr  Arg Ala Arg 
    1205                 1210                 1215             


Gly Ile  Leu Glu Ala Leu Ala  Met Glu Thr Cys Tyr  Ser Leu Tyr 
    1220                 1225                 1230             


Ser Pro  Arg Val Ala Leu Met  Glu Thr Thr Tyr Arg  Leu Tyr Ser 
    1235                 1240                 1245             


Ala Ser  Asn Thr His Arg Gly  Leu Tyr Leu Tyr Ser  Ser Glu Arg 
    1250                 1255                 1260             


Gly Leu  Gly Leu Asn Cys Tyr  Ser Ile Leu Glu Ile  Leu Glu Val 
    1265                 1270                 1275             


Ala Leu  Ala Ser Asn Ala Ser  Asn Gly Leu Ala Ser  Pro Leu Glu 
    1280                 1285                 1290             


Pro His  Glu Pro His Glu Ile  Leu Glu Ala Leu Ala  Ala Ser Asn 
    1295                 1300                 1305             


Leu Tyr  Ser Ala Ser Pro Ser  Glu Arg Pro His Glu  Ser Glu Arg 
    1310                 1315                 1320             


Leu Tyr  Ser Ala Ser Pro Leu  Glu Ala Leu Ala Leu  Tyr Ser Ala 
    1325                 1330                 1335             


Leu Ala  Gly Leu Thr His Arg  Ile Leu Glu Ala Leu  Ala Thr Tyr 
    1340                 1345                 1350             


Arg Ala  Ser Asn Thr His Arg  Gly Leu Asn Ala Ser  Asn Ala Ser 
    1355                 1360                 1365             


Asn Thr  His Arg Ile Leu Glu  Gly Leu Ala Ser Asn  Ala Ser Asn 
    1370                 1375                 1380             


Pro His  Glu Ser Glu Arg Ile  Leu Glu Ala Ser Pro  Gly Leu Asn 
    1385                 1390                 1395             


Leu Glu  Ile Leu Glu Leu Glu  Ala Ser Pro Ala Ser  Asn Ala Ser 
    1400                 1405                 1410             


Pro Leu  Glu Ser Glu Arg Ser  Glu Arg Gly Leu Tyr  Ile Leu Glu 
    1415                 1420                 1425             


Ala Ser  Pro Leu Glu Pro Arg  Ala Ser Asn Gly Leu  Ala Ser Asn 
    1430                 1435                 1440             


Thr His  Arg Gly Leu Pro Arg  Pro His Glu Thr His  Arg Ala Ser 
    1445                 1450                 1455             


Asn Pro  His Glu Ala Ser Pro  Ala Ser Pro Ile Leu  Glu Ala Ser 
    1460                 1465                 1470             


Pro Ile  Leu Glu Pro Arg Val  Ala Leu Thr Tyr Arg  Ile Leu Glu 
    1475                 1480                 1485             


Leu Tyr  Ser Gly Leu Asn Ser  Glu Arg Ala Leu Ala  Leu Glu Leu 
    1490                 1495                 1500             


Tyr Ser  Leu Tyr Ser Ile Leu  Glu Pro His Glu Val  Ala Leu Ala 
    1505                 1510                 1515             


Ser Pro  Gly Leu Tyr Ala Ser  Pro Ser Glu Arg Leu  Glu Pro His 
    1520                 1525                 1530             


Glu Gly  Leu Thr Tyr Arg Leu  Glu His Ile Ser Ala  Leu Ala Gly 
    1535                 1540                 1545             


Leu Asn  Thr His Arg Pro His  Glu Pro Arg Ser Glu  Arg Ala Ser 
    1550                 1555                 1560             


Asn Ile  Leu Glu Gly Leu Ala  Ser Asn Leu Glu Gly  Leu Asn Leu 
    1565                 1570                 1575             


Glu Thr  His Arg Ala Ser Asn  Ser Glu Arg Leu Glu  Ala Ser Asn 
    1580                 1585                 1590             


Ala Ser  Pro Ala Leu Ala Leu  Glu Ala Arg Gly Ala  Ser Asn Ala 
    1595                 1600                 1605             


Ser Asn  Ala Ser Asn Leu Tyr  Ser Val Ala Leu Thr  Tyr Arg Thr 
    1610                 1615                 1620             


His Arg  Pro His Glu Pro His  Glu Ser Glu Arg Thr  His Arg Ala 
    1625                 1630                 1635             


Ser Asn  Leu Glu Val Ala Leu  Gly Leu Leu Tyr Ser  Ala Leu Ala 
    1640                 1645                 1650             


Ala Ser  Asn Thr His Arg Val  Ala Leu Val Ala Leu  Gly Leu Tyr 
    1655                 1660                 1665             


Ala Leu  Ala Ser Glu Arg Leu  Glu Pro His Glu Val  Ala Leu Ala 
    1670                 1675                 1680             


Ser Asn  Thr Arg Pro Val Ala  Leu Leu Tyr Ser Gly  Leu Tyr Val 
    1685                 1690                 1695             


Ala Leu  Ile Leu Glu Ala Ser  Pro Ala Ser Pro Pro  His Glu Thr 
    1700                 1705                 1710             


His Arg  Ser Glu Arg Gly Leu  Ser Glu Arg Thr His  Arg Gly Leu 
    1715                 1720                 1725             


Asn Leu  Tyr Ser Ser Glu Arg  Thr His Arg Ile Leu  Glu Ala Ser 
    1730                 1735                 1740             


Pro Leu  Tyr Ser Val Ala Leu  Ser Glu Arg Ala Ser  Pro Val Ala 
    1745                 1750                 1755             


Leu Ser  Glu Arg Ile Leu Glu  Ile Leu Glu Ile Leu  Glu Pro Arg 
    1760                 1765                 1770             


Thr Tyr  Arg Ile Leu Glu Gly  Leu Tyr Pro Arg Ala  Leu Ala Leu 
    1775                 1780                 1785             


Glu Ala  Ser Asn Val Ala Leu  Gly Leu Tyr Ala Ser  Asn Gly Leu 
    1790                 1795                 1800             


Thr His  Arg Ala Leu Ala Leu  Tyr Ser Gly Leu Ala  Ser Asn Pro 
    1805                 1810                 1815             


His Glu  Leu Tyr Ser Ala Ser  Asn Ala Leu Ala Pro  His Glu Gly 
    1820                 1825                 1830             


Leu Ile  Leu Glu Gly Leu Tyr  Gly Leu Tyr Ala Leu  Ala Ala Leu 
    1835                 1840                 1845             


Ala Ile  Leu Glu Leu Glu Met  Glu Thr Gly Leu Pro  His Glu Ile 
    1850                 1855                 1860             


Leu Glu  Pro Arg Gly Leu Leu  Glu Ile Leu Glu Val  Ala Leu Pro 
    1865                 1870                 1875             


Arg Ile  Leu Glu Val Ala Leu  Gly Leu Tyr Pro His  Glu Pro His 
    1880                 1885                 1890             


Glu Thr  His Arg Leu Glu Gly  Leu Ser Glu Arg Thr  Tyr Arg Val 
    1895                 1900                 1905             


Ala Leu  Gly Leu Tyr Ala Ser  Asn Leu Tyr Ser Gly  Leu Tyr His 
    1910                 1915                 1920             


Ile Ser  Ile Leu Glu Ile Leu  Glu Met Glu Thr Thr  His Arg Ile 
    1925                 1930                 1935             


Leu Glu  Ser Glu Arg Ala Ser  Asn Ala Leu Ala Leu  Glu Leu Tyr 
    1940                 1945                 1950             


Ser Leu  Tyr Ser Ala Arg Gly  Ala Ser Pro Gly Leu  Asn Leu Tyr 
    1955                 1960                 1965             


Ser Thr  Arg Pro Thr His Arg  Ala Ser Pro Met Glu  Thr Thr Tyr 
    1970                 1975                 1980             


Arg Gly  Leu Tyr Leu Glu Ile  Leu Glu Val Ala Leu  Ser Glu Arg 
    1985                 1990                 1995             


Gly Leu  Asn Thr Arg Pro Leu  Glu Ser Glu Arg Thr  His Arg Val 
    2000                 2005                 2010             


Ala Leu  Ala Ser Asn Thr His  Arg Gly Leu Asn Pro  His Glu Thr 
    2015                 2020                 2025             


Tyr Arg  Thr His Arg Ile Leu  Glu Leu Tyr Ser Gly  Leu Ala Arg 
    2030                 2035                 2040             


Gly Met  Glu Thr Thr Tyr Arg  Ala Ser Asn Ala Leu  Ala Leu Glu 
    2045                 2050                 2055             


Ala Ser  Asn Ala Ser Asn Gly  Leu Asn Ser Glu Arg  Gly Leu Asn 
    2060                 2065                 2070             


Ala Leu  Ala Ile Leu Glu Gly  Leu Leu Tyr Ser Ile  Leu Glu Ile 
    2075                 2080                 2085             


Leu Glu  Gly Leu Ala Ser Pro  Gly Leu Asn Thr Tyr  Arg Ala Ser 
    2090                 2095                 2100             


Asn Ala  Arg Gly Thr Tyr Arg  Ser Glu Arg Gly Leu  Gly Leu Ala 
    2105                 2110                 2115             


Ser Pro  Leu Tyr Ser Met Glu  Thr Ala Ser Asn Ile  Leu Glu Ala 
    2120                 2125                 2130             


Ser Asn  Ile Leu Glu Ala Ser  Pro Pro His Glu Ala  Ser Asn Ala 
    2135                 2140                 2145             


Ser Pro  Ile Leu Glu Ala Ser  Pro Pro His Glu Leu  Tyr Ser Leu 
    2150                 2155                 2160             


Glu Ala  Ser Asn Gly Leu Asn  Ser Glu Arg Ile Leu  Glu Ala Ser 
    2165                 2170                 2175             


Asn Leu  Glu Ala Leu Ala Ile  Leu Glu Ala Ser Asn  Ala Ser Asn 
    2180                 2185                 2190             


Ile Leu  Glu Ala Ser Pro Ala  Ser Pro Pro His Glu  Ile Leu Glu 
    2195                 2200                 2205             


Ala Ser  Asn Gly Leu Asn Cys  Tyr Ser Ser Glu Arg  Ile Leu Glu 
    2210                 2215                 2220             


Ser Glu  Arg Thr Tyr Arg Leu  Glu Met Glu Thr Ala  Ser Asn Ala 
    2225                 2230                 2235             


Arg Gly  Met Glu Thr Ile Leu  Glu Pro Arg Leu Glu  Ala Leu Ala 
    2240                 2245                 2250             


Val Ala  Leu Leu Tyr Ser Leu  Tyr Ser Leu Glu Leu  Tyr Ser Ala 
    2255                 2260                 2265             


Ser Pro  Pro His Glu Ala Ser  Pro Ala Ser Pro Ala  Ser Asn Leu 
    2270                 2275                 2280             


Glu Leu  Tyr Ser Ala Arg Gly  Ala Ser Pro Leu Glu  Leu Glu Gly 
    2285                 2290                 2295             


Leu Thr  Tyr Arg Ile Leu Glu  Ala Ser Pro Thr His  Arg Ala Ser 
    2300                 2305                 2310             


Asn Gly  Leu Leu Glu Thr Tyr  Arg Leu Glu Leu Glu  Ala Ser Pro 
    2315                 2320                 2325             


Gly Leu  Val Ala Leu Ala Ser  Asn Ile Leu Glu Leu  Glu Leu Tyr 
    2330                 2335                 2340             


Ser Ser  Glu Arg Leu Tyr Ser  Val Ala Leu Ala Ser  Asn Ala Arg 
    2345                 2350                 2355             


Gly His  Ile Ser Leu Glu Leu  Tyr Ser Ala Ser Pro  Ser Glu Arg 
    2360                 2365                 2370             


Ile Leu  Glu Pro Arg Pro His  Glu Ala Ser Pro Leu  Glu Ser Glu 
    2375                 2380                 2385             


Arg Leu  Glu Thr Tyr Arg Thr  His Arg Leu Tyr Ser  Ala Ser Pro 
    2390                 2395                 2400             


Thr His  Arg Ile Leu Glu Leu  Glu Ile Leu Glu Gly  Leu Asn Val 
    2405                 2410                 2415             


Ala Leu  Pro His Glu Ala Ser  Asn Ala Ser Asn Thr  Tyr Arg Ile 
    2420                 2425                 2430             


Leu Glu  Ser Glu Arg Ala Ser  Asn Ile Leu Glu Ser  Glu Arg Ser 
    2435                 2440                 2445             


Glu Arg  Ala Ser Asn Ala Leu  Ala Ile Leu Glu Leu  Glu Ser Glu 
    2450                 2455                 2460             


Arg Leu  Glu Ser Glu Arg Thr  Tyr Arg Ala Arg Gly  Gly Leu Tyr 
    2465                 2470                 2475             


Gly Leu  Tyr Ala Arg Gly Leu  Glu Ile Leu Glu Ala  Ser Pro Ser 
    2480                 2485                 2490             


Glu Arg  Ser Glu Arg Gly Leu  Tyr Thr Tyr Arg Gly  Leu Tyr Ala 
    2495                 2500                 2505             


Leu Ala  Thr His Arg Met Glu  Thr Ala Ser Asn Val  Ala Leu Gly 
    2510                 2515                 2520             


Leu Tyr  Ser Glu Arg Ala Ser  Pro Val Ala Leu Ile  Leu Glu Pro 
    2525                 2530                 2535             


His Glu  Ala Ser Asn Ala Ser  Pro Ile Leu Glu Gly  Leu Tyr Ala 
    2540                 2545                 2550             


Ser Asn  Gly Leu Tyr Gly Leu  Asn Pro His Glu Leu  Tyr Ser Leu 
    2555                 2560                 2565             


Glu Ala  Ser Asn Ala Ser Asn  Ser Glu Arg Gly Leu  Ala Ser Asn 
    2570                 2575                 2580             


Ser Glu  Arg Ala Ser Asn Ile  Leu Glu Thr His Arg  Ala Leu Ala 
    2585                 2590                 2595             


His Ile  Ser Gly Leu Asn Ser  Glu Arg Leu Tyr Ser  Pro His Glu 
    2600                 2605                 2610             


Val Ala  Leu Val Ala Leu Thr  Tyr Arg Ala Ser Pro  Ser Glu Arg 
    2615                 2620                 2625             


Met Glu  Thr Pro His Glu Ala  Ser Pro Ala Ser Asn  Pro His Glu 
    2630                 2635                 2640             


Ser Glu  Arg Ile Leu Glu Ala  Ser Asn Pro His Glu  Thr Arg Pro 
    2645                 2650                 2655             


Val Ala  Leu Ala Arg Gly Thr  His Arg Pro Arg Leu  Tyr Ser Thr 
    2660                 2665                 2670             


Tyr Arg  Ala Ser Asn Ala Ser  Asn Ala Ser Asn Ala  Ser Pro Ile 
    2675                 2680                 2685             


Leu Glu  Gly Leu Asn Thr His  Arg Thr Tyr Arg Leu  Glu Gly Leu 
    2690                 2695                 2700             


Asn Ala  Ser Asn Gly Leu Thr  Tyr Arg Thr His Arg  Ile Leu Glu 
    2705                 2710                 2715             


Ile Leu  Glu Ser Glu Arg Cys  Tyr Ser Ile Leu Glu  Leu Tyr Ser 
    2720                 2725                 2730             


Ala Ser  Asn Ala Ser Pro Ser  Glu Arg Gly Leu Tyr  Thr Arg Pro 
    2735                 2740                 2745             


Leu Tyr  Ser Val Ala Leu Ser  Glu Arg Ile Leu Glu  Leu Tyr Ser 
    2750                 2755                 2760             


Gly Leu  Tyr Ala Ser Asn Ala  Arg Gly Ile Leu Glu  Ile Leu Glu 
    2765                 2770                 2775             


Thr Arg  Pro Thr His Arg Leu  Glu Ile Leu Glu Ala  Ser Pro Val 
    2780                 2785                 2790             


Ala Leu  Ala Ser Asn Ala Leu  Ala Leu Tyr Ser Ser  Glu Arg Leu 
    2795                 2800                 2805             


Tyr Ser  Ser Glu Arg Ile Leu  Glu Pro His Glu Pro  His Glu Gly 
    2810                 2815                 2820             


Leu Thr  Tyr Arg Ser Glu Arg  Ile Leu Glu Leu Tyr  Ser Ala Ser 
    2825                 2830                 2835             


Pro Ala  Ser Asn Ile Leu Glu  Ser Glu Arg Ala Ser  Pro Thr Tyr 
    2840                 2845                 2850             


Arg Ile  Leu Glu Ala Ser Asn  Leu Tyr Ser Thr Arg  Pro Pro His 
    2855                 2860                 2865             


Glu Ser  Glu Arg Ile Leu Glu  Thr His Arg Ile Leu  Glu Thr His 
    2870                 2875                 2880             


Arg Ala  Ser Asn Ala Ser Pro  Ala Arg Gly Leu Glu  Gly Leu Tyr 
    2885                 2890                 2895             


Ala Ser  Asn Ala Leu Ala Ala  Ser Asn Ile Leu Glu  Thr Tyr Arg 
    2900                 2905                 2910             


Ile Leu  Glu Ala Ser Asn Gly  Leu Tyr Ser Glu Arg  Leu Glu Leu 
    2915                 2920                 2925             


Tyr Ser  Leu Tyr Ser Ser Glu  Arg Gly Leu Leu Tyr  Ser Ile Leu 
    2930                 2935                 2940             


Glu Leu  Glu Ala Ser Asn Leu  Glu Ala Ser Pro Ala  Arg Gly Ile 
    2945                 2950                 2955             


Leu Glu  Ala Ser Asn Ser Glu  Arg Ser Glu Arg Ala  Ser Asn Ala 
    2960                 2965                 2970             


Ser Pro  Ile Leu Glu Ala Ser  Pro Pro His Glu Leu  Tyr Ser Leu 
    2975                 2980                 2985             


Glu Ile  Leu Glu Ala Ser Asn  Cys Tyr Ser Thr His  Arg Ala Ser 
    2990                 2995                 3000             


Pro Thr  His Arg Thr His Arg  Leu Tyr Ser Pro His  Glu Val Ala 
    3005                 3010                 3015             


Leu Thr  Arg Pro Ile Leu Glu  Leu Tyr Ser Ala Ser  Pro Pro His 
    3020                 3025                 3030             


Glu Ala  Ser Asn Ile Leu Glu  Pro His Glu Gly Leu  Tyr Ala Arg 
    3035                 3040                 3045             


Gly Gly  Leu Leu Glu Ala Ser  Asn Ala Leu Ala Thr  His Arg Gly 
    3050                 3055                 3060             


Leu Val  Ala Leu Ser Glu Arg  Ser Glu Arg Leu Glu  Thr Tyr Arg 
    3065                 3070                 3075             


Thr Arg  Pro Ile Leu Glu Gly  Leu Asn Ser Glu Arg  Ser Glu Arg 
    3080                 3085                 3090             


Thr His  Arg Ala Ser Asn Thr  His Arg Leu Glu Leu  Tyr Ser Ala 
    3095                 3100                 3105             


Ser Pro  Pro His Glu Thr Arg  Pro Gly Leu Tyr Ala  Ser Asn Pro 
    3110                 3115                 3120             


Arg Leu  Glu Ala Arg Gly Thr  Tyr Arg Ala Ser Pro  Thr His Arg 
    3125                 3130                 3135             


Gly Leu  Asn Thr Tyr Arg Thr  Tyr Arg Leu Glu Pro  His Glu Ala 
    3140                 3145                 3150             


Ser Asn  Gly Leu Asn Gly Leu  Tyr Met Glu Thr Gly  Leu Asn Ala 
    3155                 3160                 3165             


Ser Asn  Ile Leu Glu Thr Tyr  Arg Ile Leu Glu Leu  Tyr Ser Thr 
    3170                 3175                 3180             


Tyr Arg  Pro His Glu Ser Glu  Arg Leu Tyr Ser Ala  Leu Ala Ser 
    3185                 3190                 3195             


Glu Arg  Met Glu Thr Gly Leu  Tyr Gly Leu Thr His  Arg Ala Leu 
    3200                 3205                 3210             


Ala Pro  Arg Ala Arg Gly Thr  His Arg Ala Ser Asn  Pro His Glu 
    3215                 3220                 3225             


Ala Ser  Asn Ala Ser Asn Ala  Leu Ala Ala Leu Ala  Ile Leu Glu 
    3230                 3235                 3240             


Ala Ser  Asn Thr Tyr Arg Gly  Leu Asn Ala Ser Asn  Leu Glu Thr 
    3245                 3250                 3255             


Tyr Arg  Leu Glu Gly Leu Tyr  Leu Glu Ala Arg Gly  Pro His Glu 
    3260                 3265                 3270             


Ile Leu  Glu Ile Leu Glu Leu  Tyr Ser Leu Tyr Ser  Ala Leu Ala 
    3275                 3280                 3285             


Ser Glu  Arg Ala Ser Asn Ser  Glu Arg Ala Arg Gly  Ala Ser Asn 
    3290                 3295                 3300             


Ile Leu  Glu Ala Ser Asn Ala  Ser Asn Ala Ser Pro  Ala Ser Asn 
    3305                 3310                 3315             


Ile Leu  Glu Val Ala Leu Ala  Arg Gly Gly Leu Gly  Leu Tyr Ala 
    3320                 3325                 3330             


Ser Pro  Thr Tyr Arg Ile Leu  Glu Thr Tyr Arg Leu  Glu Ala Ser 
    3335                 3340                 3345             


Asn Ile  Leu Glu Ala Ser Pro  Ala Ser Asn Ile Leu  Glu Ser Glu 
    3350                 3355                 3360             


Arg Ala  Ser Pro Gly Leu Ser  Glu Arg Thr Tyr Arg  Ala Arg Gly 
    3365                 3370                 3375             


Val Ala  Leu Thr Tyr Arg Val  Ala Leu Leu Glu Val  Ala Leu Ala 
    3380                 3385                 3390             


Ser Asn  Ser Glu Arg Leu Tyr  Ser Gly Leu Ile Leu  Glu Gly Leu 
    3395                 3400                 3405             


Asn Thr  His Arg Gly Leu Asn  Leu Glu Pro His Glu  Leu Glu Ala 
    3410                 3415                 3420             


Leu Ala  Pro Arg Ile Leu Glu  Ala Ser Asn Ala Ser  Pro Ala Ser 
    3425                 3430                 3435             


Pro Pro  Arg Thr His Arg Pro  His Glu Thr Tyr Arg  Ala Ser Pro 
    3440                 3445                 3450             


Val Ala  Leu Leu Glu Gly Leu  Asn Ile Leu Glu Leu  Tyr Ser Leu 
    3455                 3460                 3465             


Tyr Ser  Thr Tyr Arg Thr Tyr  Arg Gly Leu Leu Tyr  Ser Thr His 
    3470                 3475                 3480             


Arg Thr  His Arg Thr Tyr Arg  Ala Ser Asn Cys Tyr  Ser Gly Leu 
    3485                 3490                 3495             


Asn Ile  Leu Glu Leu Glu Cys  Tyr Ser Gly Leu Leu  Tyr Ser Ala 
    3500                 3505                 3510             


Ser Pro  Thr His Arg Leu Tyr  Ser Thr His Arg Pro  His Glu Gly 
    3515                 3520                 3525             


Leu Tyr  Leu Glu Pro His Glu  Gly Leu Tyr Ile Leu  Glu Gly Leu 
    3530                 3535                 3540             


Tyr Leu  Tyr Ser Pro His Glu  Val Ala Leu Leu Tyr  Ser Ala Ser 
    3545                 3550                 3555             


Pro Thr  Tyr Arg Gly Leu Tyr  Thr Tyr Arg Val Ala  Leu Thr Arg 
    3560                 3565                 3570             


Pro Ala  Ser Pro Thr His Arg  Thr Tyr Arg Ala Ser  Pro Ala Ser 
    3575                 3580                 3585             


Asn Thr  Tyr Arg Pro His Glu  Cys Tyr Ser Ile Leu  Glu Ser Glu 
    3590                 3595                 3600             


Arg Gly  Leu Asn Thr Arg Pro  Thr Tyr Arg Leu Glu  Ala Arg Gly 
    3605                 3610                 3615             


Ala Arg  Gly Ile Leu Glu Ser  Glu Arg Gly Leu Ala  Ser Asn Ile 
    3620                 3625                 3630             


Leu Glu  Ala Ser Asn Leu Tyr  Ser Leu Glu Ala Arg  Gly Leu Glu 
    3635                 3640                 3645             


Gly Leu  Tyr Cys Tyr Ser Ala  Ser Asn Thr Arg Pro  Gly Leu Asn 
    3650                 3655                 3660             


Pro His  Glu Ile Leu Glu Pro  Arg Val Ala Leu Ala  Ser Pro Gly 
    3665                 3670                 3675             


Leu Gly  Leu Tyr Thr Arg Pro  Thr His Arg Gly Leu  
    3680                 3685                 3690 


<210>  15
<211>  4400
<212>  DNA
<213>  Clostridium botulinum

<400>  15
tagcattaaa aaaattagaa cctatagtaa ataaattaat taatatatag tttttataat       60

ttaattatga ataatattct taagataaaa agtaaatttt taaaaattta aattttcagt      120

ttacaaaaaa taacctgatt atgttatatg taattgtaaa aaacatataa aaaatcagaa      180

aaatttagga ggtatattat taatggatta aataataatt ttttaattta cttttgatta      240

ataaatatta aatgtttatt ttaattagga gatgatacgt atgccaataa ccataaataa      300

ttttagatat agtgatcctg ttaataatga tacaattatt atgatggagc caccatactg      360

taagggtcta gatatctatt ataaggcttt caaaataaca gatcgtattt ggatagtgcc      420

ggaaaggtat gaatttggga caaaacctga agattttaac ccaccatctt cattaataga      480

aggtgcatct gagtattacg atccaaatta tttaaggact gattctgata aagatagatt      540

tttacaaacc atggtaaaac tgtttaacag aattaaaaac aatgtagcag gtgaagcctt      600

attagataag ataataaatg ccatacctta ccttggaaat tcatattcct tactagacaa      660

gtttgataca aactctaatt cagtatcttt taatttatta gaacaagacc ccagtggagc      720

aactacaaaa tcagcaatgc tgacaaattt aataatattt ggacctgggc ctgttttaaa      780

taaaaatgag gttagaggta ttgtattgag ggtagataat aaaaattact tcccatgtag      840

agatggtttt ggctcaataa tgcaaatggc attttgccca gaatatgtac ctacctttga      900

taatgtaata gaaaatatta cgtcactcac tattggcaaa agcaaatatt ttcaagatcc      960

agcattacta ttaatgcacg aacttataca tgtactacat ggtttatacg gaatgcaggt     1020

atcaagccat gaaattattc catccaaaca agaaatttat atgcagcata catatccaat     1080

aagtgctgaa gaactattca cttttggcgg acaggatgct aatcttataa gtattgatat     1140

aaaaaacgat ttatatgaaa aaactttaaa tgattataaa gctatagcta acaaacttag     1200

tcaagtcact agctgcaatg atcccaacat tgatattgat agctacaaac aaatatatca     1260

acaaaaatat caattcgata aagatagcaa tggacaatat attgtaaatg aggataaatt     1320

tcagatacta tataatagca taatgtatgg ttttacagag attgaattgg gaaaaaaatt     1380

taatataaaa actagacttt cttattttag tatgaatcat gaccctgtaa aaattccaaa     1440

tttattagat gatacaattt acaatgatac agaaggattt aatatagaaa gcaaagatct     1500

gaaatctgaa tataaaggac aaaatatgag ggtaaataca aatgctttta gaaatgttga     1560

tggatcaggc ctagtttcaa aacttattgg cttatgtaaa aaaattatac caccaacaaa     1620

tataagagaa aatttatata atagaactgc atcattaaca gatttaggag gagaattatg     1680

tataaaaatt aaaaatgaag atttaacttt tatagctgaa aaaaatagct tttcagaaga     1740

accatttcaa gatgaaatag ttagttataa tacaaaaaat aaaccattaa attttaatta     1800

ttcgctagat aaaattattg tagattataa tctacaaagt aaaattacat tacctaatga     1860

taggacaacc ccagttacaa aaggaattcc atatgctcca gaatataaaa gtaatgctgc     1920

aagtacaata gaaatacata atattgatga caatacaata tatcaatatt tgtatgctca     1980

aaaatctcct acaactctac aaagaataac tatgactaat tctgttgatg acgcattaat     2040

aaattccacc aaaatatatt catattttcc atctgtaatc agtaaagtta accaaggtgc     2100

acaaggaatt ttattcttac agtgggtgag agatataatt gatgatttta ccaatgaatc     2160

ttcacaaaaa actactattg ataaaatttc agatgtatcc actattgttc cttatatagg     2220

acccgcatta aacattgtaa aacaaggcta tgagggaaac tttataggcg ctttagaaac     2280

taccggagtg gttttattat tagaatatat tccagaaatt actttaccag taattgcagc     2340

tttatctata gcagaaagta gcacacaaaa agaaaagata ataaaaacaa tagataactt     2400

tttagaaaaa agatatgaaa aatggattga agtatataaa ctagtaaaag caaaatggtt     2460

aggcacagtt aatacgcaat tccaaaaaag aagttatcaa atgtatagat ctttagaata     2520

tcaagtagat gcaataaaaa aaataataga ctatgaatat aaaatatatt caggacctga     2580

taaggaacaa attgccgacg aaattaataa tctgaaaaac aaacttgaag aaaaggctaa     2640

taaagcaatg ataaacataa atatatttat gagggaaagt tctagatcat ttttagttaa     2700

tcaaatgatt aacgaagcta aaaagcagtt attagagttt gatactcaaa gcaaaaatat     2760

tttaatgcag tatataaaag caaattctaa atttataggt ataactgaac taaaaaaatt     2820

agaatcaaaa ataaacaaag ttttttcaac accaattcca ttttcttatt ctaaaaatct     2880

ggattgttgg gttgataatg aagaagatat agatgttata ttaaaaaaga gtacaatttt     2940

aaatttagat attaataatg atattatatc agatatatct gggtttaatt catctgtaat     3000

aacatatcca gatgctcaat tggtgcccgg aataaatggc aaagcaatac atttagtaaa     3060

caatgaatct tctgaagtta tagtgcataa agctatggat attgaatata atgatatgtt     3120

taataatttt accgttagct tttggttgag ggttcctaaa gtatctgcta gtcatttaga     3180

acaatatggc acaaatgagt attcaataat tagctctatg aaaaaacata gtctatcaat     3240

aggatctggt tggagtgtat cacttaaagg taataactta atatggactt taaaagattc     3300

cgcgggagaa gttagacaaa taacttttag ggatttacct gataaattta atgcttattt     3360

agcaaataaa tgggttttta taactattac taatgataga ttatcttctg ctaatttgta     3420

tataaatgga gtacttatgg gaagtgcaga aattactggt ttaggagcta ttagagagga     3480

taataatata acattaaaac tagatagatg taataataat aatcaatacg tttctattga     3540

taaatttagg atattttgca aagcattaaa tccaaaagag attgaaaaat tatacacaag     3600

ttatttatct ataacctttt taagagactt ctggggaaac cctttacgat atgatacaga     3660

atattattta ataccagtag cttctagttc taaagatgtt caattgaaaa atataacaga     3720

ttatatgtat ttgacaaatg cgccatcgta tactaacgga aaattgaata tatattatag     3780

aaggttatat aatggactaa aatttattat aaaaagatat acacctaata atgaaataga     3840

ttcttttgtt aaatcaggtg attttattaa attatatgta tcatataaca ataatgagca     3900

cattgtaggt tatccgaaag atggaaatgc ctttaataat cttgatagaa ttctaagagt     3960

aggttataat gccccaggta tccctcttta taaaaaaatg gaagcagtaa aattgcgtga     4020

tttaaaaacc tattctgtac aacttaaatt atatgatgat aaaaatgcat ctttaggact     4080

agtaggtacc cataatggtc aaataggcaa cgatccaaat agggatatat taattgcaag     4140

caactggtac tttaatcatt taaaagataa aattttagga tgtgattggt actttgtacc     4200

tacagatgaa ggatggacaa atgattaaac agattgatat gttcatgatt actctatata     4260

aaaaattaaa taatataaca atctagctat attatttttg attattttct taatatatac     4320

taataaaata atcaaaatag agcctatctt aaattactga agggctgtgt caaaataaga     4380

ttttgacaca gcctctactt                                                 4400


<210>  16
<211>  3708
<212>  PRT
<213>  Clostridium tetani

<400>  16

Met Glu Thr Pro Arg Ile Leu Glu Thr His Arg Ile Leu Glu Ala Ser 
1               5                   10                  15      


Asn Ala Ser Asn Pro His Glu Ala Arg Gly Thr Tyr Arg Ser Glu Arg 
            20                  25                  30          


Ala Ser Pro Pro Arg Val Ala Leu Ala Ser Asn Ala Ser Asn Ala Ser 
        35                  40                  45              


Pro Thr His Arg Ile Leu Glu Ile Leu Glu Met Glu Thr Met Glu Thr 
    50                  55                  60                  


Gly Leu Pro Arg Pro Arg Thr Tyr Arg Cys Tyr Ser Leu Tyr Ser Gly 
65                  70                  75                  80  


Leu Tyr Leu Glu Ala Ser Pro Ile Leu Glu Thr Tyr Arg Thr Tyr Arg 
                85                  90                  95      


Leu Tyr Ser Ala Leu Ala Pro His Glu Leu Tyr Ser Ile Leu Glu Thr 
            100                 105                 110         


His Arg Ala Ser Pro Ala Arg Gly Ile Leu Glu Thr Arg Pro Ile Leu 
        115                 120                 125             


Glu Val Ala Leu Pro Arg Gly Leu Ala Arg Gly Thr Tyr Arg Gly Leu 
    130                 135                 140                 


Pro His Glu Gly Leu Tyr Thr His Arg Leu Tyr Ser Pro Arg Gly Leu 
145                 150                 155                 160 


Ala Ser Pro Pro His Glu Ala Ser Asn Pro Arg Pro Arg Ser Glu Arg 
                165                 170                 175     


Ser Glu Arg Leu Glu Ile Leu Glu Gly Leu Gly Leu Tyr Ala Leu Ala 
            180                 185                 190         


Ser Glu Arg Gly Leu Thr Tyr Arg Thr Tyr Arg Ala Ser Pro Pro Arg 
        195                 200                 205             


Ala Ser Asn Thr Tyr Arg Leu Glu Ala Arg Gly Thr His Arg Ala Ser 
    210                 215                 220                 


Pro Ser Glu Arg Ala Ser Pro Leu Tyr Ser Ala Ser Pro Ala Arg Gly 
225                 230                 235                 240 


Pro His Glu Leu Glu Gly Leu Asn Thr His Arg Met Glu Thr Val Ala 
                245                 250                 255     


Leu Leu Tyr Ser Leu Glu Pro His Glu Ala Ser Asn Ala Arg Gly Ile 
            260                 265                 270         


Leu Glu Leu Tyr Ser Ala Ser Asn Ala Ser Asn Val Ala Leu Ala Leu 
        275                 280                 285             


Ala Gly Leu Tyr Gly Leu Ala Leu Ala Leu Glu Leu Glu Ala Ser Pro 
    290                 295                 300                 


Leu Tyr Ser Ile Leu Glu Ile Leu Glu Ala Ser Asn Ala Leu Ala Ile 
305                 310                 315                 320 


Leu Glu Pro Arg Thr Tyr Arg Leu Glu Gly Leu Tyr Ala Ser Asn Ser 
                325                 330                 335     


Glu Arg Thr Tyr Arg Ser Glu Arg Leu Glu Leu Glu Ala Ser Pro Leu 
            340                 345                 350         


Tyr Ser Pro His Glu Ala Ser Pro Thr His Arg Ala Ser Asn Ser Glu 
        355                 360                 365             


Arg Ala Ser Asn Ser Glu Arg Val Ala Leu Ser Glu Arg Pro His Glu 
    370                 375                 380                 


Ala Ser Asn Leu Glu Leu Glu Gly Leu Gly Leu Asn Ala Ser Pro Pro 
385                 390                 395                 400 


Arg Ser Glu Arg Gly Leu Tyr Ala Leu Ala Thr His Arg Thr His Arg 
                405                 410                 415     


Leu Tyr Ser Ser Glu Arg Ala Leu Ala Met Glu Thr Leu Glu Thr His 
            420                 425                 430         


Arg Ala Ser Asn Leu Glu Ile Leu Glu Ile Leu Glu Pro His Glu Gly 
        435                 440                 445             


Leu Tyr Pro Arg Gly Leu Tyr Pro Arg Val Ala Leu Leu Glu Ala Ser 
    450                 455                 460                 


Asn Leu Tyr Ser Ala Ser Asn Gly Leu Val Ala Leu Ala Arg Gly Gly 
465                 470                 475                 480 


Leu Tyr Ile Leu Glu Val Ala Leu Leu Glu Ala Arg Gly Val Ala Leu 
                485                 490                 495     


Ala Ser Pro Ala Ser Asn Leu Tyr Ser Ala Ser Asn Thr Tyr Arg Pro 
            500                 505                 510         


His Glu Pro Arg Cys Tyr Ser Ala Arg Gly Ala Ser Pro Gly Leu Tyr 
        515                 520                 525             


Pro His Glu Gly Leu Tyr Ser Glu Arg Ile Leu Glu Met Glu Thr Gly 
    530                 535                 540                 


Leu Asn Met Glu Thr Ala Leu Ala Pro His Glu Cys Tyr Ser Pro Arg 
545                 550                 555                 560 


Gly Leu Thr Tyr Arg Val Ala Leu Pro Arg Thr His Arg Pro His Glu 
                565                 570                 575     


Ala Ser Pro Ala Ser Asn Val Ala Leu Ile Leu Glu Gly Leu Ala Ser 
            580                 585                 590         


Asn Ile Leu Glu Thr His Arg Ser Glu Arg Leu Glu Thr His Arg Ile 
        595                 600                 605             


Leu Glu Gly Leu Tyr Leu Tyr Ser Ser Glu Arg Leu Tyr Ser Thr Tyr 
    610                 615                 620                 


Arg Pro His Glu Gly Leu Asn Ala Ser Pro Pro Arg Ala Leu Ala Leu 
625                 630                 635                 640 


Glu Leu Glu Leu Glu Met Glu Thr His Ile Ser Gly Leu Leu Glu Ile 
                645                 650                 655     


Leu Glu His Ile Ser Val Ala Leu Leu Glu His Ile Ser Gly Leu Tyr 
            660                 665                 670         


Leu Glu Thr Tyr Arg Gly Leu Tyr Met Glu Thr Gly Leu Asn Val Ala 
        675                 680                 685             


Leu Ser Glu Arg Ser Glu Arg His Ile Ser Gly Leu Ile Leu Glu Ile 
    690                 695                 700                 


Leu Glu Pro Arg Ser Glu Arg Leu Tyr Ser Gly Leu Asn Gly Leu Ile 
705                 710                 715                 720 


Leu Glu Thr Tyr Arg Met Glu Thr Gly Leu Asn His Ile Ser Thr His 
                725                 730                 735     


Arg Thr Tyr Arg Pro Arg Ile Leu Glu Ser Glu Arg Ala Leu Ala Gly 
            740                 745                 750         


Leu Gly Leu Leu Glu Pro His Glu Thr His Arg Pro His Glu Gly Leu 
        755                 760                 765             


Tyr Gly Leu Tyr Gly Leu Asn Ala Ser Pro Ala Leu Ala Ala Ser Asn 
    770                 775                 780                 


Leu Glu Ile Leu Glu Ser Glu Arg Ile Leu Glu Ala Ser Pro Ile Leu 
785                 790                 795                 800 


Glu Leu Tyr Ser Ala Ser Asn Ala Ser Pro Leu Glu Thr Tyr Arg Gly 
                805                 810                 815     


Leu Leu Tyr Ser Thr His Arg Leu Glu Ala Ser Asn Ala Ser Pro Thr 
            820                 825                 830         


Tyr Arg Leu Tyr Ser Ala Leu Ala Ile Leu Glu Ala Leu Ala Ala Ser 
        835                 840                 845             


Asn Leu Tyr Ser Leu Glu Ser Glu Arg Gly Leu Asn Val Ala Leu Thr 
    850                 855                 860                 


His Arg Ser Glu Arg Cys Tyr Ser Ala Ser Asn Ala Ser Pro Pro Arg 
865                 870                 875                 880 


Ala Ser Asn Ile Leu Glu Ala Ser Pro Ile Leu Glu Ala Ser Pro Ser 
                885                 890                 895     


Glu Arg Thr Tyr Arg Leu Tyr Ser Gly Leu Asn Ile Leu Glu Thr Tyr 
            900                 905                 910         


Arg Gly Leu Asn Gly Leu Asn Leu Tyr Ser Thr Tyr Arg Gly Leu Asn 
        915                 920                 925             


Pro His Glu Ala Ser Pro Leu Tyr Ser Ala Ser Pro Ser Glu Arg Ala 
    930                 935                 940                 


Ser Asn Gly Leu Tyr Gly Leu Asn Thr Tyr Arg Ile Leu Glu Val Ala 
945                 950                 955                 960 


Leu Ala Ser Asn Gly Leu Ala Ser Pro Leu Tyr Ser Pro His Glu Gly 
                965                 970                 975     


Leu Asn Ile Leu Glu Leu Glu Thr Tyr Arg Ala Ser Asn Ser Glu Arg 
            980                 985                 990         


Ile Leu Glu Met Glu Thr Thr Tyr  Arg Gly Leu Tyr Pro  His Glu Thr 
        995                 1000                 1005             


His Arg  Gly Leu Ile Leu Glu  Gly Leu Leu Glu Gly  Leu Tyr Leu 
    1010                 1015                 1020             


Tyr Ser  Leu Tyr Ser Pro His  Glu Ala Ser Asn Ile  Leu Glu Leu 
    1025                 1030                 1035             


Tyr Ser  Thr His Arg Ala Arg  Gly Leu Glu Ser Glu  Arg Thr Tyr 
    1040                 1045                 1050             


Arg Pro  His Glu Ser Glu Arg  Met Glu Thr Ala Ser  Asn His Ile 
    1055                 1060                 1065             


Ser Ala  Ser Pro Pro Arg Val  Ala Leu Leu Tyr Ser  Ile Leu Glu 
    1070                 1075                 1080             


Pro Arg  Ala Ser Asn Leu Glu  Leu Glu Ala Ser Pro  Ala Ser Pro 
    1085                 1090                 1095             


Thr His  Arg Ile Leu Glu Thr  Tyr Arg Ala Ser Asn  Ala Ser Pro 
    1100                 1105                 1110             


Thr His  Arg Gly Leu Gly Leu  Tyr Pro His Glu Ala  Ser Asn Ile 
    1115                 1120                 1125             


Leu Glu  Gly Leu Ser Glu Arg  Leu Tyr Ser Ala Ser  Pro Leu Glu 
    1130                 1135                 1140             


Leu Tyr  Ser Ser Glu Arg Gly  Leu Thr Tyr Arg Leu  Tyr Ser Gly 
    1145                 1150                 1155             


Leu Tyr  Gly Leu Asn Ala Ser  Asn Met Glu Thr Ala  Arg Gly Val 
    1160                 1165                 1170             


Ala Leu  Ala Ser Asn Thr His  Arg Ala Ser Asn Ala  Leu Ala Pro 
    1175                 1180                 1185             


His Glu  Ala Arg Gly Ala Ser  Asn Val Ala Leu Ala  Ser Pro Gly 
    1190                 1195                 1200             


Leu Tyr  Ser Glu Arg Gly Leu  Tyr Leu Glu Val Ala  Leu Ser Glu 
    1205                 1210                 1215             


Arg Leu  Tyr Ser Leu Glu Ile  Leu Glu Gly Leu Tyr  Leu Glu Cys 
    1220                 1225                 1230             


Tyr Ser  Leu Tyr Ser Leu Tyr  Ser Ile Leu Glu Ile  Leu Glu Pro 
    1235                 1240                 1245             


Arg Pro  Arg Thr His Arg Ala  Ser Asn Ile Leu Glu  Ala Arg Gly 
    1250                 1255                 1260             


Gly Leu  Ala Ser Asn Leu Glu  Thr Tyr Arg Ala Ser  Asn Ala Arg 
    1265                 1270                 1275             


Gly Thr  His Arg Ala Leu Ala  Ser Glu Arg Leu Glu  Thr His Arg 
    1280                 1285                 1290             


Ala Ser  Pro Leu Glu Gly Leu  Tyr Gly Leu Tyr Gly  Leu Leu Glu 
    1295                 1300                 1305             


Cys Tyr  Ser Ile Leu Glu Leu  Tyr Ser Ile Leu Glu  Leu Tyr Ser 
    1310                 1315                 1320             


Ala Ser  Asn Gly Leu Ala Ser  Pro Leu Glu Thr His  Arg Pro His 
    1325                 1330                 1335             


Glu Ile  Leu Glu Ala Leu Ala  Gly Leu Leu Tyr Ser  Ala Ser Asn 
    1340                 1345                 1350             


Ser Glu  Arg Pro His Glu Ser  Glu Arg Gly Leu Gly  Leu Pro Arg 
    1355                 1360                 1365             


Pro His  Glu Gly Leu Asn Ala  Ser Pro Gly Leu Ile  Leu Glu Val 
    1370                 1375                 1380             


Ala Leu  Ser Glu Arg Thr Tyr  Arg Ala Ser Asn Thr  His Arg Leu 
    1385                 1390                 1395             


Tyr Ser  Ala Ser Asn Leu Tyr  Ser Pro Arg Leu Glu  Ala Ser Asn 
    1400                 1405                 1410             


Pro His  Glu Ala Ser Asn Thr  Tyr Arg Ser Glu Arg  Leu Glu Ala 
    1415                 1420                 1425             


Ser Pro  Leu Tyr Ser Ile Leu  Glu Ile Leu Glu Val  Ala Leu Ala 
    1430                 1435                 1440             


Ser Pro  Thr Tyr Arg Ala Ser  Asn Leu Glu Gly Leu  Asn Ser Glu 
    1445                 1450                 1455             


Arg Leu  Tyr Ser Ile Leu Glu  Thr His Arg Leu Glu  Pro Arg Ala 
    1460                 1465                 1470             


Ser Asn  Ala Ser Pro Ala Arg  Gly Thr His Arg Thr  His Arg Pro 
    1475                 1480                 1485             


Arg Val  Ala Leu Thr His Arg  Leu Tyr Ser Gly Leu  Tyr Ile Leu 
    1490                 1495                 1500             


Glu Pro  Arg Thr Tyr Arg Ala  Leu Ala Pro Arg Gly  Leu Thr Tyr 
    1505                 1510                 1515             


Arg Leu  Tyr Ser Ser Glu Arg  Ala Ser Asn Ala Leu  Ala Ala Leu 
    1520                 1525                 1530             


Ala Ser  Glu Arg Thr His Arg  Ile Leu Glu Gly Leu  Ile Leu Glu 
    1535                 1540                 1545             


His Ile  Ser Ala Ser Asn Ile  Leu Glu Ala Ser Pro  Ala Ser Pro 
    1550                 1555                 1560             


Ala Ser  Asn Thr His Arg Ile  Leu Glu Thr Tyr Arg  Gly Leu Asn 
    1565                 1570                 1575             


Thr Tyr  Arg Leu Glu Thr Tyr  Arg Ala Leu Ala Gly  Leu Asn Leu 
    1580                 1585                 1590             


Tyr Ser  Ser Glu Arg Pro Arg  Thr His Arg Thr His  Arg Leu Glu 
    1595                 1600                 1605             


Gly Leu  Asn Ala Arg Gly Ile  Leu Glu Thr His Arg  Met Glu Thr 
    1610                 1615                 1620             


Thr His  Arg Ala Ser Asn Ser  Glu Arg Val Ala Leu  Ala Ser Pro 
    1625                 1630                 1635             


Ala Ser  Pro Ala Leu Ala Leu  Glu Ile Leu Glu Ala  Ser Asn Ser 
    1640                 1645                 1650             


Glu Arg  Thr His Arg Leu Tyr  Ser Ile Leu Glu Thr  Tyr Arg Ser 
    1655                 1660                 1665             


Glu Arg  Thr Tyr Arg Pro His  Glu Pro Arg Ser Glu  Arg Val Ala 
    1670                 1675                 1680             


Leu Ile  Leu Glu Ser Glu Arg  Leu Tyr Ser Val Ala  Leu Ala Ser 
    1685                 1690                 1695             


Asn Gly  Leu Asn Gly Leu Tyr  Ala Leu Ala Gly Leu  Asn Gly Leu 
    1700                 1705                 1710             


Tyr Ile  Leu Glu Leu Glu Pro  His Glu Leu Glu Gly  Leu Asn Thr 
    1715                 1720                 1725             


Arg Pro  Val Ala Leu Ala Arg  Gly Ala Ser Pro Ile  Leu Glu Ile 
    1730                 1735                 1740             


Leu Glu  Ala Ser Pro Ala Ser  Pro Pro His Glu Thr  His Arg Ala 
    1745                 1750                 1755             


Ser Asn  Gly Leu Ser Glu Arg  Ser Glu Arg Gly Leu  Asn Leu Tyr 
    1760                 1765                 1770             


Ser Thr  His Arg Thr His Arg  Ile Leu Glu Ala Ser  Pro Leu Tyr 
    1775                 1780                 1785             


Ser Ile  Leu Glu Ser Glu Arg  Ala Ser Pro Val Ala  Leu Ser Glu 
    1790                 1795                 1800             


Arg Thr  His Arg Ile Leu Glu  Val Ala Leu Pro Arg  Thr Tyr Arg 
    1805                 1810                 1815             


Ile Leu  Glu Gly Leu Tyr Pro  Arg Ala Leu Ala Leu  Glu Ala Ser 
    1820                 1825                 1830             


Asn Ile  Leu Glu Val Ala Leu  Leu Tyr Ser Gly Leu  Asn Gly Leu 
    1835                 1840                 1845             


Tyr Thr  Tyr Arg Gly Leu Gly  Leu Tyr Ala Ser Asn  Pro His Glu 
    1850                 1855                 1860             


Ile Leu  Glu Gly Leu Tyr Ala  Leu Ala Leu Glu Gly  Leu Thr His 
    1865                 1870                 1875             


Arg Thr  His Arg Gly Leu Tyr  Val Ala Leu Val Ala  Leu Leu Glu 
    1880                 1885                 1890             


Leu Glu  Leu Glu Gly Leu Thr  Tyr Arg Ile Leu Glu  Pro Arg Gly 
    1895                 1900                 1905             


Leu Ile  Leu Glu Thr His Arg  Leu Glu Pro Arg Val  Ala Leu Ile 
    1910                 1915                 1920             


Leu Glu  Ala Leu Ala Ala Leu  Ala Leu Glu Ser Glu  Arg Ile Leu 
    1925                 1930                 1935             


Glu Ala  Leu Ala Gly Leu Ser  Glu Arg Ser Glu Arg  Thr His Arg 
    1940                 1945                 1950             


Gly Leu  Asn Leu Tyr Ser Gly  Leu Leu Tyr Ser Ile  Leu Glu Ile 
    1955                 1960                 1965             


Leu Glu  Leu Tyr Ser Thr His  Arg Ile Leu Glu Ala  Ser Pro Ala 
    1970                 1975                 1980             


Ser Asn  Pro His Glu Leu Glu  Gly Leu Leu Tyr Ser  Ala Arg Gly 
    1985                 1990                 1995             


Thr Tyr  Arg Gly Leu Leu Tyr  Ser Thr Arg Pro Ile  Leu Glu Gly 
    2000                 2005                 2010             


Leu Val  Ala Leu Thr Tyr Arg  Leu Tyr Ser Leu Glu  Val Ala Leu 
    2015                 2020                 2025             


Leu Tyr  Ser Ala Leu Ala Leu  Tyr Ser Thr Arg Pro  Leu Glu Gly 
    2030                 2035                 2040             


Leu Tyr  Thr His Arg Val Ala  Leu Ala Ser Asn Thr  His Arg Gly 
    2045                 2050                 2055             


Leu Asn  Pro His Glu Gly Leu  Asn Leu Tyr Ser Ala  Arg Gly Ser 
    2060                 2065                 2070             


Glu Arg  Thr Tyr Arg Gly Leu  Asn Met Glu Thr Thr  Tyr Arg Ala 
    2075                 2080                 2085             


Arg Gly  Ser Glu Arg Leu Glu  Gly Leu Thr Tyr Arg  Gly Leu Asn 
    2090                 2095                 2100             


Val Ala  Leu Ala Ser Pro Ala  Leu Ala Ile Leu Glu  Leu Tyr Ser 
    2105                 2110                 2115             


Leu Tyr  Ser Ile Leu Glu Ile  Leu Glu Ala Ser Pro  Thr Tyr Arg 
    2120                 2125                 2130             


Gly Leu  Thr Tyr Arg Leu Tyr  Ser Ile Leu Glu Thr  Tyr Arg Ser 
    2135                 2140                 2145             


Glu Arg  Gly Leu Tyr Pro Arg  Ala Ser Pro Leu Tyr  Ser Gly Leu 
    2150                 2155                 2160             


Gly Leu  Asn Ile Leu Glu Ala  Leu Ala Ala Ser Pro  Gly Leu Ile 
    2165                 2170                 2175             


Leu Glu  Ala Ser Asn Ala Ser  Asn Leu Glu Leu Tyr  Ser Ala Ser 
    2180                 2185                 2190             


Asn Leu  Tyr Ser Leu Glu Gly  Leu Gly Leu Leu Tyr  Ser Ala Leu 
    2195                 2200                 2205             


Ala Ala  Ser Asn Leu Tyr Ser  Ala Leu Ala Met Glu  Thr Ile Leu 
    2210                 2215                 2220             


Glu Ala  Ser Asn Ile Leu Glu  Ala Ser Asn Ile Leu  Glu Pro His 
    2225                 2230                 2235             


Glu Met  Glu Thr Ala Arg Gly  Gly Leu Ser Glu Arg  Ser Glu Arg 
    2240                 2245                 2250             


Ala Arg  Gly Ser Glu Arg Pro  His Glu Leu Glu Val  Ala Leu Ala 
    2255                 2260                 2265             


Ser Asn  Gly Leu Asn Met Glu  Thr Ile Leu Glu Ala  Ser Asn Gly 
    2270                 2275                 2280             


Leu Ala  Leu Ala Leu Tyr Ser  Leu Tyr Ser Gly Leu  Asn Leu Glu 
    2285                 2290                 2295             


Leu Glu  Gly Leu Pro His Glu  Ala Ser Pro Thr His  Arg Gly Leu 
    2300                 2305                 2310             


Asn Ser  Glu Arg Leu Tyr Ser  Ala Ser Asn Ile Leu  Glu Leu Glu 
    2315                 2320                 2325             


Met Glu  Thr Gly Leu Asn Thr  Tyr Arg Ile Leu Glu  Leu Tyr Ser 
    2330                 2335                 2340             


Ala Leu  Ala Ala Ser Asn Ser  Glu Arg Leu Tyr Ser  Pro His Glu 
    2345                 2350                 2355             


Ile Leu  Glu Gly Leu Tyr Ile  Leu Glu Thr His Arg  Gly Leu Leu 
    2360                 2365                 2370             


Glu Leu  Tyr Ser Leu Tyr Ser  Leu Glu Gly Leu Ser  Glu Arg Leu 
    2375                 2380                 2385             


Tyr Ser  Ile Leu Glu Ala Ser  Asn Leu Tyr Ser Val  Ala Leu Pro 
    2390                 2395                 2400             


His Glu  Ser Glu Arg Thr His  Arg Pro Arg Ile Leu  Glu Pro Arg 
    2405                 2410                 2415             


Pro His  Glu Ser Glu Arg Thr  Tyr Arg Ser Glu Arg  Leu Tyr Ser 
    2420                 2425                 2430             


Ala Ser  Asn Leu Glu Ala Ser  Pro Cys Tyr Ser Thr  Arg Pro Val 
    2435                 2440                 2445             


Ala Leu  Ala Ser Pro Ala Ser  Asn Gly Leu Gly Leu  Ala Ser Pro 
    2450                 2455                 2460             


Ile Leu  Glu Ala Ser Pro Val  Ala Leu Ile Leu Glu  Leu Glu Leu 
    2465                 2470                 2475             


Tyr Ser  Leu Tyr Ser Ser Glu  Arg Thr His Arg Ile  Leu Glu Leu 
    2480                 2485                 2490             


Glu Ala  Ser Asn Leu Glu Ala  Ser Pro Ile Leu Glu  Ala Ser Asn 
    2495                 2500                 2505             


Ala Ser  Asn Ala Ser Pro Ile  Leu Glu Ile Leu Glu  Ser Glu Arg 
    2510                 2515                 2520             


Ala Ser  Pro Ile Leu Glu Ser  Glu Arg Gly Leu Tyr  Pro His Glu 
    2525                 2530                 2535             


Ala Ser  Asn Ser Glu Arg Ser  Glu Arg Val Ala Leu  Ile Leu Glu 
    2540                 2545                 2550             


Thr His  Arg Thr Tyr Arg Pro  Arg Ala Ser Pro Ala  Leu Ala Gly 
    2555                 2560                 2565             


Leu Asn  Leu Glu Val Ala Leu  Pro Arg Gly Leu Tyr  Ile Leu Glu 
    2570                 2575                 2580             


Ala Ser  Asn Gly Leu Tyr Leu  Tyr Ser Ala Leu Ala  Ile Leu Glu 
    2585                 2590                 2595             


His Ile  Ser Leu Glu Val Ala  Leu Ala Ser Asn Ala  Ser Asn Gly 
    2600                 2605                 2610             


Leu Ser  Glu Arg Ser Glu Arg  Gly Leu Val Ala Leu  Ile Leu Glu 
    2615                 2620                 2625             


Val Ala  Leu His Ile Ser Leu  Tyr Ser Ala Leu Ala  Met Glu Thr 
    2630                 2635                 2640             


Ala Ser  Pro Ile Leu Glu Gly  Leu Thr Tyr Arg Ala  Ser Asn Ala 
    2645                 2650                 2655             


Ser Pro  Met Glu Thr Pro His  Glu Ala Ser Asn Ala  Ser Asn Pro 
    2660                 2665                 2670             


His Glu  Thr His Arg Val Ala  Leu Ser Glu Arg Pro  His Glu Thr 
    2675                 2680                 2685             


Arg Pro  Leu Glu Ala Arg Gly  Val Ala Leu Pro Arg  Leu Tyr Ser 
    2690                 2695                 2700             


Val Ala  Leu Ser Glu Arg Ala  Leu Ala Ser Glu Arg  His Ile Ser 
    2705                 2710                 2715             


Leu Glu  Gly Leu Gly Leu Asn  Thr Tyr Arg Gly Leu  Tyr Thr His 
    2720                 2725                 2730             


Arg Ala  Ser Asn Gly Leu Thr  Tyr Arg Ser Glu Arg  Ile Leu Glu 
    2735                 2740                 2745             


Ile Leu  Glu Ser Glu Arg Ser  Glu Arg Met Glu Thr  Leu Tyr Ser 
    2750                 2755                 2760             


Leu Tyr  Ser His Ile Ser Ser  Glu Arg Leu Glu Ser  Glu Arg Ile 
    2765                 2770                 2775             


Leu Glu  Gly Leu Tyr Ser Glu  Arg Gly Leu Tyr Thr  Arg Pro Ser 
    2780                 2785                 2790             


Glu Arg  Val Ala Leu Ser Glu  Arg Leu Glu Leu Tyr  Ser Gly Leu 
    2795                 2800                 2805             


Tyr Ala  Ser Asn Ala Ser Asn  Leu Glu Ile Leu Glu  Thr Arg Pro 
    2810                 2815                 2820             


Thr His  Arg Leu Glu Leu Tyr  Ser Ala Ser Pro Ser  Glu Arg Ala 
    2825                 2830                 2835             


Leu Ala  Gly Leu Tyr Gly Leu  Val Ala Leu Ala Arg  Gly Gly Leu 
    2840                 2845                 2850             


Asn Ile  Leu Glu Thr His Arg  Pro His Glu Ala Arg  Gly Ala Ser 
    2855                 2860                 2865             


Pro Leu  Glu Pro Arg Ala Ser  Pro Leu Tyr Ser Pro  His Glu Ala 
    2870                 2875                 2880             


Ser Asn  Ala Leu Ala Thr Tyr  Arg Leu Glu Ala Leu  Ala Ala Ser 
    2885                 2890                 2895             


Asn Leu  Tyr Ser Thr Arg Pro  Val Ala Leu Pro His  Glu Ile Leu 
    2900                 2905                 2910             


Glu Thr  His Arg Ile Leu Glu  Thr His Arg Ala Ser  Asn Ala Ser 
    2915                 2920                 2925             


Pro Ala  Arg Gly Leu Glu Ser  Glu Arg Ser Glu Arg  Ala Leu Ala 
    2930                 2935                 2940             


Ala Ser  Asn Leu Glu Thr Tyr  Arg Ile Leu Glu Ala  Ser Asn Gly 
    2945                 2950                 2955             


Leu Tyr  Val Ala Leu Leu Glu  Met Glu Thr Gly Leu  Tyr Ser Glu 
    2960                 2965                 2970             


Arg Ala  Leu Ala Gly Leu Ile  Leu Glu Thr His Arg  Gly Leu Tyr 
    2975                 2980                 2985             


Leu Glu  Gly Leu Tyr Ala Leu  Ala Ile Leu Glu Ala  Arg Gly Gly 
    2990                 2995                 3000             


Leu Ala  Ser Pro Ala Ser Asn  Ala Ser Asn Ile Leu  Glu Thr His 
    3005                 3010                 3015             


Arg Leu  Glu Leu Tyr Ser Leu  Glu Ala Ser Pro Ala  Arg Gly Cys 
    3020                 3025                 3030             


Tyr Ser  Ala Ser Asn Ala Ser  Asn Ala Ser Asn Ala  Ser Asn Gly 
    3035                 3040                 3045             


Leu Asn  Thr Tyr Arg Val Ala  Leu Ser Glu Arg Ile  Leu Glu Ala 
    3050                 3055                 3060             


Ser Pro  Leu Tyr Ser Pro His  Glu Ala Arg Gly Ile  Leu Glu Pro 
    3065                 3070                 3075             


His Glu  Cys Tyr Ser Leu Tyr  Ser Ala Leu Ala Leu  Glu Ala Ser 
    3080                 3085                 3090             


Asn Pro  Arg Leu Tyr Ser Gly  Leu Ile Leu Glu Gly  Leu Leu Tyr 
    3095                 3100                 3105             


Ser Leu  Glu Thr Tyr Arg Thr  His Arg Ser Glu Arg  Thr Tyr Arg 
    3110                 3115                 3120             


Leu Glu  Ser Glu Arg Ile Leu  Glu Thr His Arg Pro  His Glu Leu 
    3125                 3130                 3135             


Glu Ala  Arg Gly Ala Ser Pro  Pro His Glu Thr Arg  Pro Gly Leu 
    3140                 3145                 3150             


Tyr Ala  Ser Asn Pro Arg Leu  Glu Ala Arg Gly Thr  Tyr Arg Ala 
    3155                 3160                 3165             


Ser Pro  Thr His Arg Gly Leu  Thr Tyr Arg Thr Tyr  Arg Leu Glu 
    3170                 3175                 3180             


Ile Leu  Glu Pro Arg Val Ala  Leu Ala Leu Ala Ser  Glu Arg Ser 
    3185                 3190                 3195             


Glu Arg  Ser Glu Arg Leu Tyr  Ser Ala Ser Pro Val  Ala Leu Gly 
    3200                 3205                 3210             


Leu Asn  Leu Glu Leu Tyr Ser  Ala Ser Asn Ile Leu  Glu Thr His 
    3215                 3220                 3225             


Arg Ala  Ser Pro Thr Tyr Arg  Met Glu Thr Thr Tyr  Arg Leu Glu 
    3230                 3235                 3240             


Thr His  Arg Ala Ser Asn Ala  Leu Ala Pro Arg Ser  Glu Arg Thr 
    3245                 3250                 3255             


Tyr Arg  Thr His Arg Ala Ser  Asn Gly Leu Tyr Leu  Tyr Ser Leu 
    3260                 3265                 3270             


Glu Ala  Ser Asn Ile Leu Glu  Thr Tyr Arg Thr Tyr  Arg Ala Arg 
    3275                 3280                 3285             


Gly Ala  Arg Gly Leu Glu Thr  Tyr Arg Ala Ser Asn  Gly Leu Tyr 
    3290                 3295                 3300             


Leu Glu  Leu Tyr Ser Pro His  Glu Ile Leu Glu Ile  Leu Glu Leu 
    3305                 3310                 3315             


Tyr Ser  Ala Arg Gly Thr Tyr  Arg Thr His Arg Pro  Arg Ala Ser 
    3320                 3325                 3330             


Asn Ala  Ser Asn Gly Leu Ile  Leu Glu Ala Ser Pro  Ser Glu Arg 
    3335                 3340                 3345             


Pro His  Glu Val Ala Leu Leu  Tyr Ser Ser Glu Arg  Gly Leu Tyr 
    3350                 3355                 3360             


Ala Ser  Pro Pro His Glu Ile  Leu Glu Leu Tyr Ser  Leu Glu Thr 
    3365                 3370                 3375             


Tyr Arg  Val Ala Leu Ser Glu  Arg Thr Tyr Arg Ala  Ser Asn Ala 
    3380                 3385                 3390             


Ser Asn  Ala Ser Asn Gly Leu  His Ile Ser Ile Leu  Glu Val Ala 
    3395                 3400                 3405             


Leu Gly  Leu Tyr Thr Tyr Arg  Pro Arg Leu Tyr Ser  Ala Ser Pro 
    3410                 3415                 3420             


Gly Leu  Tyr Ala Ser Asn Ala  Leu Ala Pro His Glu  Ala Ser Asn 
    3425                 3430                 3435             


Ala Ser  Asn Leu Glu Ala Ser  Pro Ala Arg Gly Ile  Leu Glu Leu 
    3440                 3445                 3450             


Glu Ala  Arg Gly Val Ala Leu  Gly Leu Tyr Thr Tyr  Arg Ala Ser 
    3455                 3460                 3465             


Asn Ala  Leu Ala Pro Arg Gly  Leu Tyr Ile Leu Glu  Pro Arg Leu 
    3470                 3475                 3480             


Glu Thr  Tyr Arg Leu Tyr Ser  Leu Tyr Ser Met Glu  Thr Gly Leu 
    3485                 3490                 3495             


Ala Leu  Ala Val Ala Leu Leu  Tyr Ser Leu Glu Ala  Arg Gly Ala 
    3500                 3505                 3510             


Ser Pro  Leu Glu Leu Tyr Ser  Thr His Arg Thr Tyr  Arg Ser Glu 
    3515                 3520                 3525             


Arg Val  Ala Leu Gly Leu Asn  Leu Glu Leu Tyr Ser  Leu Glu Thr 
    3530                 3535                 3540             


Tyr Arg  Ala Ser Pro Ala Ser  Pro Leu Tyr Ser Ala  Ser Asn Ala 
    3545                 3550                 3555             


Leu Ala  Ser Glu Arg Leu Glu  Gly Leu Tyr Leu Glu  Val Ala Leu 
    3560                 3565                 3570             


Gly Leu  Tyr Thr His Arg His  Ile Ser Ala Ser Asn  Gly Leu Tyr 
    3575                 3580                 3585             


Gly Leu  Asn Ile Leu Glu Gly  Leu Tyr Ala Ser Asn  Ala Ser Pro 
    3590                 3595                 3600             


Pro Arg  Ala Ser Asn Ala Arg  Gly Ala Ser Pro Ile  Leu Glu Leu 
    3605                 3610                 3615             


Glu Ile  Leu Glu Ala Leu Ala  Ser Glu Arg Ala Ser  Asn Thr Arg 
    3620                 3625                 3630             


Pro Thr  Tyr Arg Pro His Glu  Ala Ser Asn His Ile  Ser Leu Glu 
    3635                 3640                 3645             


Leu Tyr  Ser Ala Ser Pro Leu  Tyr Ser Ile Leu Glu  Leu Glu Gly 
    3650                 3655                 3660             


Leu Tyr  Cys Tyr Ser Ala Ser  Pro Thr Arg Pro Thr  Tyr Arg Pro 
    3665                 3670                 3675             


His Glu  Val Ala Leu Pro Arg  Thr His Arg Ala Ser  Pro Gly Leu 
    3680                 3685                 3690             


Gly Leu  Tyr Thr Arg Pro Thr  His Arg Ala Ser Asn  Ala Ser Pro 
    3695                 3700                 3705             


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Histidine motif

<400>  17

His Glu Leu Ile His  
1               5        


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Histidine motif

<400>  18

His Glu Leu Met His  
1               5       


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Histidine motif

<400>  19

His Glu Leu Thr His  
1               5   



<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Histidine motif consensus


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  20

His Glu Leu Xaa His 
1               5                   


