                         SEQUENCE LISTING

<110>  Health Protection Agency
       Micropharm Limited
       Shone, Clifford
       Roberts, April
       Ahern, Helen
       Maynard-Smith, Michael
 
<120>  Clostridium difficile antigens

<130>  P33260WO-MRM

<150>  GB 1016742.7
<151>  2010-10-05

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  2710
<212>  PRT
<213>  Clostridium difficile

<400>  1

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile 
1               5                   10                  15      


Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu 
            20                  25                  30          


Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu 
        35                  40                  45              


Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr 
    50                  55                  60                  


Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys 
65                  70                  75                  80  


Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn 
                85                  90                  95      


Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu 
            100                 105                 110         


Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu 
        115                 120                 125             


Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile 
    130                 135                 140                 


Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile 
145                 150                 155                 160 


Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu 
                165                 170                 175     


Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln 
            180                 185                 190         


Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His 
        195                 200                 205             


Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg 
    210                 215                 220                 


Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg 
225                 230                 235                 240 


Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln 
                245                 250                 255     


Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg 
            260                 265                 270         


Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met 
        275                 280                 285             


Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser 
    290                 295                 300                 


Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met 
305                 310                 315                 320 


Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys 
                325                 330                 335     


Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys 
            340                 345                 350         


Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser 
        355                 360                 365             


Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln 
    370                 375                 380                 


Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu 
385                 390                 395                 400 


Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala 
                405                 410                 415     


Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp 
            420                 425                 430         


Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys 
        435                 440                 445             


Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr 
    450                 455                 460                 


Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe 
465                 470                 475                 480 


Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp 
                485                 490                 495     


Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu 
            500                 505                 510         


Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr 
        515                 520                 525             


Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu 
    530                 535                 540                 


Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr 
545                 550                 555                 560 


Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser 
                565                 570                 575     


Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser 
            580                 585                 590         


Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile 
        595                 600                 605             


Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser 
    610                 615                 620                 


Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu 
625                 630                 635                 640 


Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly 
                645                 650                 655     


Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser 
            660                 665                 670         


Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile 
        675                 680                 685             


Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser 
    690                 695                 700                 


Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser 
705                 710                 715                 720 


Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser 
                725                 730                 735     


Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly 
            740                 745                 750         


Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu 
        755                 760                 765             


Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser 
    770                 775                 780                 


Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala 
785                 790                 795                 800 


Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser 
                805                 810                 815     


Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser 
            820                 825                 830         


Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn 
        835                 840                 845             


Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu 
    850                 855                 860                 


Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu 
865                 870                 875                 880 


Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser 
                885                 890                 895     


Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr 
            900                 905                 910         


Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr 
        915                 920                 925             


Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly 
    930                 935                 940                 


Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr 
945                 950                 955                 960 


Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn 
                965                 970                 975     


Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr 
            980                 985                 990         


Ala Gln Leu Phe Ser Thr Gly Leu  Asn Thr Ile Tyr Asp  Ser Ile Gln 
        995                 1000                 1005             


Leu Val  Asn Leu Ile Ser Asn  Ala Val Asn Asp Thr  Ile Asn Val 
    1010                 1015                 1020             


Leu Pro  Thr Ile Thr Glu Gly  Ile Pro Ile Val Ser  Thr Ile Leu 
    1025                 1030                 1035             


Asp Gly  Ile Asn Leu Gly Ala  Ala Ile Lys Glu Leu  Leu Asp Glu 
    1040                 1045                 1050             


His Asp  Pro Leu Leu Lys Lys  Glu Leu Glu Ala Lys  Val Gly Val 
    1055                 1060                 1065             


Leu Ala  Ile Asn Met Ser Leu  Ser Ile Ala Ala Thr  Val Ala Ser 
    1070                 1075                 1080             


Ile Val  Gly Ile Gly Ala Glu  Val Thr Ile Phe Leu  Leu Pro Ile 
    1085                 1090                 1095             


Ala Gly  Ile Ser Ala Gly Ile  Pro Ser Leu Val Asn  Asn Glu Leu 
    1100                 1105                 1110             


Ile Leu  His Asp Lys Ala Thr  Ser Val Val Asn Tyr  Phe Asn His 
    1115                 1120                 1125             


Leu Ser  Glu Ser Lys Lys Tyr  Gly Pro Leu Lys Thr  Glu Asp Asp 
    1130                 1135                 1140             


Lys Ile  Leu Val Pro Ile Asp  Asp Leu Val Ile Ser  Glu Ile Asp 
    1145                 1150                 1155             


Phe Asn  Asn Asn Ser Ile Lys  Leu Gly Thr Cys Asn  Ile Leu Ala 
    1160                 1165                 1170             


Met Glu  Gly Gly Ser Gly His  Thr Val Thr Gly Asn  Ile Asp His 
    1175                 1180                 1185             


Phe Phe  Ser Ser Pro Ser Ile  Ser Ser His Ile Pro  Ser Leu Ser 
    1190                 1195                 1200             


Ile Tyr  Ser Ala Ile Gly Ile  Glu Thr Glu Asn Leu  Asp Phe Ser 
    1205                 1210                 1215             


Lys Lys  Ile Met Met Leu Pro  Asn Ala Pro Ser Arg  Val Phe Trp 
    1220                 1225                 1230             


Trp Glu  Thr Gly Ala Val Pro  Gly Leu Arg Ser Leu  Glu Asn Asp 
    1235                 1240                 1245             


Gly Thr  Arg Leu Leu Asp Ser  Ile Arg Asp Leu Tyr  Pro Gly Lys 
    1250                 1255                 1260             


Phe Tyr  Trp Arg Phe Tyr Ala  Phe Phe Asp Tyr Ala  Ile Thr Thr 
    1265                 1270                 1275             


Leu Lys  Pro Val Tyr Glu Asp  Thr Asn Ile Lys Ile  Lys Leu Asp 
    1280                 1285                 1290             


Lys Asp  Thr Arg Asn Phe Ile  Met Pro Thr Ile Thr  Thr Asn Glu 
    1295                 1300                 1305             


Ile Arg  Asn Lys Leu Ser Tyr  Ser Phe Asp Gly Ala  Gly Gly Thr 
    1310                 1315                 1320             


Tyr Ser  Leu Leu Leu Ser Ser  Tyr Pro Ile Ser Thr  Asn Ile Asn 
    1325                 1330                 1335             


Leu Ser  Lys Asp Asp Leu Trp  Ile Phe Asn Ile Asp  Asn Glu Val 
    1340                 1345                 1350             


Arg Glu  Ile Ser Ile Glu Asn  Gly Thr Ile Lys Lys  Gly Lys Leu 
    1355                 1360                 1365             


Ile Lys  Asp Val Leu Ser Lys  Ile Asp Ile Asn Lys  Asn Lys Leu 
    1370                 1375                 1380             


Ile Ile  Gly Asn Gln Thr Ile  Asp Phe Ser Gly Asp  Ile Asp Asn 
    1385                 1390                 1395             


Lys Asp  Arg Tyr Ile Phe Leu  Thr Cys Glu Leu Asp  Asp Lys Ile 
    1400                 1405                 1410             


Ser Leu  Ile Ile Glu Ile Asn  Leu Val Ala Lys Ser  Tyr Ser Leu 
    1415                 1420                 1425             


Leu Leu  Ser Gly Asp Lys Asn  Tyr Leu Ile Ser Asn  Leu Ser Asn 
    1430                 1435                 1440             


Thr Ile  Glu Lys Ile Asn Thr  Leu Gly Leu Asp Ser  Lys Asn Ile 
    1445                 1450                 1455             


Ala Tyr  Asn Tyr Thr Asp Glu  Ser Asn Asn Lys Tyr  Phe Gly Ala 
    1460                 1465                 1470             


Ile Ser  Lys Thr Ser Gln Lys  Ser Ile Ile His Tyr  Lys Lys Asp 
    1475                 1480                 1485             


Ser Lys  Asn Ile Leu Glu Phe  Tyr Asn Asp Ser Thr  Leu Glu Phe 
    1490                 1495                 1500             


Asn Ser  Lys Asp Phe Ile Ala  Glu Asp Ile Asn Val  Phe Met Lys 
    1505                 1510                 1515             


Asp Asp  Ile Asn Thr Ile Thr  Gly Lys Tyr Tyr Val  Asp Asn Asn 
    1520                 1525                 1530             


Thr Asp  Lys Ser Ile Asp Phe  Ser Ile Ser Leu Val  Ser Lys Asn 
    1535                 1540                 1545             


Gln Val  Lys Val Asn Gly Leu  Tyr Leu Asn Glu Ser  Val Tyr Ser 
    1550                 1555                 1560             


Ser Tyr  Leu Asp Phe Val Lys  Asn Ser Asp Gly His  His Asn Thr 
    1565                 1570                 1575             


Ser Asn  Phe Met Asn Leu Phe  Leu Asp Asn Ile Ser  Phe Trp Lys 
    1580                 1585                 1590             


Leu Phe  Gly Phe Glu Asn Ile  Asn Phe Val Ile Asp  Lys Tyr Phe 
    1595                 1600                 1605             


Thr Leu  Val Gly Lys Thr Asn  Leu Gly Tyr Val Glu  Phe Ile Cys 
    1610                 1615                 1620             


Asp Asn  Asn Lys Asn Ile Asp  Ile Tyr Phe Gly Glu  Trp Lys Thr 
    1625                 1630                 1635             


Ser Ser  Ser Lys Ser Thr Ile  Phe Ser Gly Asn Gly  Arg Asn Val 
    1640                 1645                 1650             


Val Val  Glu Pro Ile Tyr Asn  Pro Asp Thr Gly Glu  Asp Ile Ser 
    1655                 1660                 1665             


Thr Ser  Leu Asp Phe Ser Tyr  Glu Pro Leu Tyr Gly  Ile Asp Arg 
    1670                 1675                 1680             


Tyr Ile  Asn Lys Val Leu Ile  Ala Pro Asp Leu Tyr  Thr Ser Leu 
    1685                 1690                 1695             


Ile Asn  Ile Asn Thr Asn Tyr  Tyr Ser Asn Glu Tyr  Tyr Pro Glu 
    1700                 1705                 1710             


Ile Ile  Val Leu Asn Pro Asn  Thr Phe His Lys Lys  Val Asn Ile 
    1715                 1720                 1725             


Asn Leu  Asp Ser Ser Ser Phe  Glu Tyr Lys Trp Ser  Thr Glu Gly 
    1730                 1735                 1740             


Ser Asp  Phe Ile Leu Val Arg  Tyr Leu Glu Glu Ser  Asn Lys Lys 
    1745                 1750                 1755             


Ile Leu  Gln Lys Ile Arg Ile  Lys Gly Ile Leu Ser  Asn Thr Gln 
    1760                 1765                 1770             


Ser Phe  Asn Lys Met Ser Ile  Asp Phe Lys Asp Ile  Lys Lys Leu 
    1775                 1780                 1785             


Ser Leu  Gly Tyr Ile Met Ser  Asn Phe Lys Ser Phe  Asn Ser Glu 
    1790                 1795                 1800             


Asn Glu  Leu Asp Arg Asp His  Leu Gly Phe Lys Ile  Ile Asp Asn 
    1805                 1810                 1815             


Lys Thr  Tyr Tyr Tyr Asp Glu  Asp Ser Lys Leu Val  Lys Gly Leu 
    1820                 1825                 1830             


Ile Asn  Ile Asn Asn Ser Leu  Phe Tyr Phe Asp Pro  Ile Glu Phe 
    1835                 1840                 1845             


Asn Leu  Val Thr Gly Trp Gln  Thr Ile Asn Gly Lys  Lys Tyr Tyr 
    1850                 1855                 1860             


Phe Asp  Ile Asn Thr Gly Ala  Ala Leu Thr Ser Tyr  Lys Ile Ile 
    1865                 1870                 1875             


Asn Gly  Lys His Phe Tyr Phe  Asn Asn Asp Gly Val  Met Gln Leu 
    1880                 1885                 1890             


Gly Val  Phe Lys Gly Pro Asp  Gly Phe Glu Tyr Phe  Ala Pro Ala 
    1895                 1900                 1905             


Asn Thr  Gln Asn Asn Asn Ile  Glu Gly Gln Ala Ile  Val Tyr Gln 
    1910                 1915                 1920             


Ser Lys  Phe Leu Thr Leu Asn  Gly Lys Lys Tyr Tyr  Phe Asp Asn 
    1925                 1930                 1935             


Asn Ser  Lys Ala Val Thr Gly  Trp Arg Ile Ile Asn  Asn Glu Lys 
    1940                 1945                 1950             


Tyr Tyr  Phe Asn Pro Asn Asn  Ala Ile Ala Ala Val  Gly Leu Gln 
    1955                 1960                 1965             


Val Ile  Asp Asn Asn Lys Tyr  Tyr Phe Asn Pro Asp  Thr Ala Ile 
    1970                 1975                 1980             


Ile Ser  Lys Gly Trp Gln Thr  Val Asn Gly Ser Arg  Tyr Tyr Phe 
    1985                 1990                 1995             


Asp Thr  Asp Thr Ala Ile Ala  Phe Asn Gly Tyr Lys  Thr Ile Asp 
    2000                 2005                 2010             


Gly Lys  His Phe Tyr Phe Asp  Ser Asp Cys Val Val  Lys Ile Gly 
    2015                 2020                 2025             


Val Phe  Ser Thr Ser Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn 
    2030                 2035                 2040             


Thr Tyr  Asn Asn Asn Ile Glu  Gly Gln Ala Ile Val  Tyr Gln Ser 
    2045                 2050                 2055             


Lys Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr Tyr Phe  Asp Asn Asn 
    2060                 2065                 2070             


Ser Lys  Ala Val Thr Gly Leu  Gln Thr Ile Asp Ser  Lys Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asn Thr Asn Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr 
    2090                 2095                 2100             


Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr Asn Thr  Ala Glu Ala 
    2105                 2110                 2115             


Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn 
    2120                 2125                 2130             


Thr Asn  Thr Ala Ile Ala Ser  Thr Gly Tyr Thr Ile  Ile Asn Gly 
    2135                 2140                 2145             


Lys His  Phe Tyr Phe Asn Thr  Asp Gly Ile Met Gln  Ile Gly Val 
    2150                 2155                 2160             


Phe Lys  Gly Pro Asn Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr 
    2165                 2170                 2175             


Asp Ala  Asn Asn Ile Glu Gly  Gln Ala Ile Leu Tyr  Gln Asn Glu 
    2180                 2185                 2190             


Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr Phe Gly  Ser Asp Ser 
    2195                 2200                 2205             


Lys Ala  Val Thr Gly Trp Arg  Ile Ile Asn Asn Lys  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asn  Pro Asn Asn Ala Ile  Ala Ala Ile His Leu  Cys Thr Ile 
    2225                 2230                 2235             


Asn Asn  Asp Lys Tyr Tyr Phe  Ser Tyr Asp Gly Ile  Leu Gln Asn 
    2240                 2245                 2250             


Gly Tyr  Ile Thr Ile Glu Arg  Asn Asn Phe Tyr Phe  Asp Ala Asn 
    2255                 2260                 2265             


Asn Glu  Ser Lys Met Val Thr  Gly Val Phe Lys Gly  Pro Asn Gly 
    2270                 2275                 2280             


Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr His Asn Asn  Asn Ile Glu 
    2285                 2290                 2295             


Gly Gln  Ala Ile Val Tyr Gln  Asn Lys Phe Leu Thr  Leu Asn Gly 
    2300                 2305                 2310             


Lys Lys  Tyr Tyr Phe Asp Asn  Asp Ser Lys Ala Val  Thr Gly Trp 
    2315                 2320                 2325             


Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe Asn Leu  Asn Thr Ala 
    2330                 2335                 2340             


Glu Ala  Ala Thr Gly Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr 
    2345                 2350                 2355             


Phe Asn  Leu Asn Thr Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile 
    2360                 2365                 2370             


Asp Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn Thr Phe  Ile Ala Ser 
    2375                 2380                 2385             


Thr Gly  Tyr Thr Ser Ile Asn  Gly Lys His Phe Tyr  Phe Asn Thr 
    2390                 2395                 2400             


Asp Gly  Ile Met Gln Ile Gly  Val Phe Lys Gly Pro  Asn Gly Phe 
    2405                 2410                 2415             


Glu Tyr  Phe Ala Pro Ala Asn  Thr Asp Ala Asn Asn  Ile Glu Gly 
    2420                 2425                 2430             


Gln Ala  Ile Leu Tyr Gln Asn  Lys Phe Leu Thr Leu  Asn Gly Lys 
    2435                 2440                 2445             


Lys Tyr  Tyr Phe Gly Ser Asp  Ser Lys Ala Val Thr  Gly Leu Arg 
    2450                 2455                 2460             


Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Val 
    2465                 2470                 2475             


Ala Val  Thr Gly Trp Gln Thr  Ile Asn Gly Lys Lys  Tyr Tyr Phe 
    2480                 2485                 2490             


Asn Thr  Asn Thr Ser Ile Ala  Ser Thr Gly Tyr Thr  Ile Ile Ser 
    2495                 2500                 2505             


Gly Lys  His Phe Tyr Phe Asn  Thr Asp Gly Ile Met  Gln Ile Gly 
    2510                 2515                 2520             


Val Phe  Lys Gly Pro Asp Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn 
    2525                 2530                 2535             


Thr Asp  Ala Asn Asn Ile Glu  Gly Gln Ala Ile Arg  Tyr Gln Asn 
    2540                 2545                 2550             


Arg Phe  Leu Tyr Leu His Asp  Asn Ile Tyr Tyr Phe  Gly Asn Asn 
    2555                 2560                 2565             


Ser Lys  Ala Ala Thr Gly Trp  Val Thr Ile Asp Gly  Asn Arg Tyr 
    2570                 2575                 2580             


Tyr Phe  Glu Pro Asn Thr Ala  Met Gly Ala Asn Gly  Tyr Lys Thr 
    2585                 2590                 2595             


Ile Asp  Asn Lys Asn Phe Tyr  Phe Arg Asn Gly Leu  Pro Gln Ile 
    2600                 2605                 2610             


Gly Val  Phe Lys Gly Ser Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala 
    2615                 2620                 2625             


Asn Thr  Asp Ala Asn Asn Ile  Glu Gly Gln Ala Ile  Arg Tyr Gln 
    2630                 2635                 2640             


Asn Arg  Phe Leu His Leu Leu  Gly Lys Ile Tyr Tyr  Phe Gly Asn 
    2645                 2650                 2655             


Asn Ser  Lys Ala Val Thr Gly  Trp Gln Thr Ile Asn  Gly Lys Val 
    2660                 2665                 2670             


Tyr Tyr  Phe Met Pro Asp Thr  Ala Met Ala Ala Ala  Gly Gly Leu 
    2675                 2680                 2685             


Phe Glu  Ile Asp Gly Val Ile  Tyr Phe Phe Gly Val  Asp Gly Val 
    2690                 2695                 2700             


Lys Ala  Pro Gly Ile Tyr Gly  
    2705                 2710 


<210>  2
<211>  2366
<212>  PRT
<213>  Clostridium difficile

<400>  2

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met 
                165                 170                 175     


Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly 
    530                 535                 540                 


Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu 
545                 550                 555                 560 


Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
                565                 570                 575     


Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         


Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe 
        595                 600                 605             


Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly 
    610                 615                 620                 


Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile 
625                 630                 635                 640 


Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp 
                645                 650                 655     


Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser 
            660                 665                 670         


Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro 
        675                 680                 685             


Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 


Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
705                 710                 715                 720 


Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     


Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         


Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             


Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu 
    770                 775                 780                 


Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 


Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu 
                805                 810                 815     


Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile 
            820                 825                 830         


Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr 
        835                 840                 845             


Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 


Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp 
865                 870                 875                 880 


Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe 
                885                 890                 895     


Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         


Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu 
        915                 920                 925             


Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 


Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 


Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu 
                965                 970                 975     


Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         


Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val 
        995                 1000                 1005             


Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro 
    1010                 1015                 1020             


Thr Leu  Ser Glu Gly Leu Pro  Ile Ile Ala Thr Ile  Ile Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Gly Ala Ala Ile  Lys Glu Leu Ser Glu  Thr Ser Asp 
    1040                 1045                 1050             


Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala 
    1055                 1060                 1065             


Val Asn  Leu Thr Thr Ala Thr  Thr Ala Ile Ile Thr  Ser Ser Leu 
    1070                 1075                 1080             


Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly 
    1085                 1090                 1095             


Ile Ser  Ala Gly Ile Pro Ser  Leu Val Asn Asn Glu  Leu Val Leu 
    1100                 1105                 1110             


Arg Asp  Lys Ala Thr Lys Val  Val Asp Tyr Phe Lys  His Val Ser 
    1115                 1120                 1125             


Leu Val  Glu Thr Glu Gly Val  Phe Thr Leu Leu Asp  Asp Lys Ile 
    1130                 1135                 1140             


Met Met  Pro Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn 
    1145                 1150                 1155             


Asn Asn  Ser Ile Val Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu 
    1160                 1165                 1170             


Gly Gly  Ser Gly His Thr Val  Thr Asp Asp Ile Asp  His Phe Phe 
    1175                 1180                 1185             


Ser Ala  Pro Ser Ile Thr Tyr  Arg Glu Pro His Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Asp Val  Leu Glu Val Gln Lys  Glu Glu Leu Asp Leu  Ser Lys Asp 
    1205                 1210                 1215             


Leu Met  Val Leu Pro Asn Ala  Pro Asn Arg Val Phe  Ala Trp Glu 
    1220                 1225                 1230             


Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu Glu Asn  Asp Gly Thr 
    1235                 1240                 1245             


Lys Leu  Leu Asp Arg Ile Arg  Asp Asn Tyr Glu Gly  Glu Phe Tyr 
    1250                 1255                 1260             


Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala Leu Ile  Thr Thr Leu 
    1265                 1270                 1275             


Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg Ile Asn  Leu Asp Ser 
    1280                 1285                 1290             


Asn Thr  Arg Ser Phe Ile Val  Pro Ile Ile Thr Thr  Glu Tyr Ile 
    1295                 1300                 1305             


Arg Glu  Lys Leu Ser Tyr Ser  Phe Tyr Gly Ser Gly  Gly Thr Tyr 
    1310                 1315                 1320             


Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Gly Ile Asn  Ile Glu Leu 
    1325                 1330                 1335             


Ser Glu  Ser Asp Val Trp Ile  Ile Asp Val Asp Asn  Val Val Arg 
    1340                 1345                 1350             


Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile 
    1355                 1360                 1365             


Glu Gly  Ile Leu Ser Thr Leu  Ser Ile Glu Glu Asn  Lys Ile Ile 
    1370                 1375                 1380             


Leu Asn  Ser His Glu Ile Asn  Phe Ser Gly Glu Val  Asn Gly Ser 
    1385                 1390                 1395             


Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Ile  Ile Glu Val Asp Leu  Leu Ser Lys Ser Tyr  Lys Leu Leu 
    1415                 1420                 1425             


Ile Ser  Gly Glu Leu Lys Ile  Leu Met Leu Asn Ser  Asn His Ile 
    1430                 1435                 1440             


Gln Gln  Lys Ile Asp Tyr Ile  Gly Phe Asn Ser Glu  Leu Gln Lys 
    1445                 1450                 1455             


Asn Ile  Pro Tyr Ser Phe Val  Asp Ser Glu Gly Lys  Glu Asn Gly 
    1460                 1465                 1470             


Phe Ile  Asn Gly Ser Thr Lys  Glu Gly Leu Phe Val  Ser Glu Leu 
    1475                 1480                 1485             


Pro Asp  Val Val Leu Ile Ser  Lys Val Tyr Met Asp  Asp Ser Lys 
    1490                 1495                 1500             


Pro Ser  Phe Gly Tyr Tyr Ser  Asn Asn Leu Lys Asp  Val Lys Val 
    1505                 1510                 1515             


Ile Thr  Lys Asp Asn Val Asn  Ile Leu Thr Gly Tyr  Tyr Leu Lys 
    1520                 1525                 1530             


Asp Asp  Ile Lys Ile Ser Leu  Ser Leu Thr Leu Gln  Asp Glu Lys 
    1535                 1540                 1545             


Thr Ile  Lys Leu Asn Ser Val  His Leu Asp Glu Ser  Gly Val Ala 
    1550                 1555                 1560             


Glu Ile  Leu Lys Phe Met Asn  Arg Lys Gly Asn Thr  Asn Thr Ser 
    1565                 1570                 1575             


Asp Ser  Leu Met Ser Phe Leu  Glu Ser Met Asn Ile  Lys Ser Ile 
    1580                 1585                 1590             


Phe Val  Asn Phe Leu Gln Ser  Asn Ile Lys Phe Ile  Leu Asp Ala 
    1595                 1600                 1605             


Asn Phe  Ile Ile Ser Gly Thr  Thr Ser Ile Gly Gln  Phe Glu Phe 
    1610                 1615                 1620             


Ile Cys  Asp Glu Asn Asp Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe 
    1625                 1630                 1635             


Asn Thr  Leu Glu Thr Asn Tyr  Thr Leu Tyr Val Gly  Asn Arg Gln 
    1640                 1645                 1650             


Asn Met  Ile Val Glu Pro Asn  Tyr Asp Leu Asp Asp  Ser Gly Asp 
    1655                 1660                 1665             


Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly 
    1670                 1675                 1680             


Ile Asp  Ser Cys Val Asn Lys  Val Val Ile Ser Pro  Asn Ile Tyr 
    1685                 1690                 1695             


Thr Asp  Glu Ile Asn Ile Thr  Pro Val Tyr Glu Thr  Asn Asn Thr 
    1700                 1705                 1710             


Tyr Pro  Glu Val Ile Val Leu  Asp Ala Asn Tyr Ile  Asn Glu Lys 
    1715                 1720                 1725             


Ile Asn  Val Asn Ile Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser 
    1730                 1735                 1740             


Asn Asp  Gly Asn Asp Phe Ile  Leu Met Ser Thr Ser  Glu Glu Asn 
    1745                 1750                 1755             


Lys Val  Ser Gln Val Lys Ile  Arg Phe Val Asn Val  Phe Lys Asp 
    1760                 1765                 1770             


Lys Thr  Leu Ala Asn Lys Leu  Ser Phe Asn Phe Ser  Asp Lys Gln 
    1775                 1780                 1785             


Asp Val  Pro Val Ser Glu Ile  Ile Leu Ser Phe Thr  Pro Ser Tyr 
    1790                 1795                 1800             


Tyr Glu  Asp Gly Leu Ile Gly  Tyr Asp Leu Gly Leu  Val Ser Leu 
    1805                 1810                 1815             


Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser 
    1820                 1825                 1830             


Gly Leu  Ile Tyr Ile Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro 
    1835                 1840                 1845             


Val Asn  Asn Leu Ile Thr Gly  Phe Val Thr Val Gly  Asp Asp Lys 
    1850                 1855                 1860             


Tyr Tyr  Phe Asn Pro Ile Asn  Gly Gly Ala Ala Ser  Ile Gly Glu 
    1865                 1870                 1875             


Thr Ile  Ile Asp Asp Lys Asn  Tyr Tyr Phe Asn Gln  Ser Gly Val 
    1880                 1885                 1890             


Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1895                 1900                 1905             


Ala Pro  Ala Asn Thr Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile 
    1910                 1915                 1920             


Asp Phe  Thr Gly Lys Leu Ile  Ile Asp Glu Asn Ile  Tyr Tyr Phe 
    1925                 1930                 1935             


Asp Asp  Asn Tyr Arg Gly Ala  Val Glu Trp Lys Glu  Leu Asp Gly 
    1940                 1945                 1950             


Glu Met  His Tyr Phe Ser Pro  Glu Thr Gly Lys Ala  Phe Lys Gly 
    1955                 1960                 1965             


Leu Asn  Gln Ile Gly Asp Tyr  Lys Tyr Tyr Phe Asn  Ser Asp Gly 
    1970                 1975                 1980             


Val Met  Gln Lys Gly Phe Val  Ser Ile Asn Asp Asn  Lys His Tyr 
    1985                 1990                 1995             


Phe Asp  Asp Ser Gly Val Met  Lys Val Gly Tyr Thr  Glu Ile Asp 
    2000                 2005                 2010             


Gly Lys  His Phe Tyr Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly 
    2015                 2020                 2025             


Val Phe  Asn Thr Glu Asp Gly  Phe Lys Tyr Phe Ala  His His Asn 
    2030                 2035                 2040             


Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Glu Ile Ser  Tyr Ser Gly 
    2045                 2050                 2055             


Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe 
    2060                 2065                 2070             


Thr Ala  Val Val Gly Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asp Glu Asp Thr Ala  Glu Ala Tyr Ile Gly  Leu Ser Leu 
    2090                 2095                 2100             


Ile Asn  Asp Gly Gln Tyr Tyr  Phe Asn Asp Asp Gly  Ile Met Gln 
    2105                 2110                 2115             


Val Gly  Phe Val Thr Ile Asn  Asp Lys Val Phe Tyr  Phe Ser Asp 
    2120                 2125                 2130             


Ser Gly  Ile Ile Glu Ser Gly  Val Gln Asn Ile Asp  Asp Asn Tyr 
    2135                 2140                 2145             


Phe Tyr  Ile Asp Asp Asn Gly  Ile Val Gln Ile Gly  Val Phe Asp 
    2150                 2155                 2160             


Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn 
    2165                 2170                 2175             


Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr Ser Gly  Leu Val Arg 
    2180                 2185                 2190             


Val Gly  Glu Asp Val Tyr Tyr  Phe Gly Glu Thr Tyr  Thr Ile Glu 
    2195                 2200                 2205             


Thr Gly  Trp Ile Tyr Asp Met  Glu Asn Glu Ser Asp  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asn  Pro Glu Thr Lys Lys  Ala Cys Lys Gly Ile  Asn Leu Ile 
    2225                 2230                 2235             


Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Lys Gly Ile  Met Arg Thr 
    2240                 2245                 2250             


Gly Leu  Ile Ser Phe Glu Asn  Asn Asn Tyr Tyr Phe  Asn Glu Asn 
    2255                 2260                 2265             


Gly Glu  Met Gln Phe Gly Tyr  Ile Asn Ile Glu Asp  Lys Met Phe 
    2270                 2275                 2280             


Tyr Phe  Gly Glu Asp Gly Val  Met Gln Ile Gly Val  Phe Asn Thr 
    2285                 2290                 2295             


Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln Asn Thr  Leu Asp Glu 
    2300                 2305                 2310             


Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu 
    2315                 2320                 2325             


Asp Glu  Lys Arg Tyr Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr 
    2330                 2335                 2340             


Gly Ser  Val Ile Ile Asp Gly  Glu Glu Tyr Tyr Phe  Asp Pro Asp 
    2345                 2350                 2355             


Thr Ala  Gln Leu Val Ile Ser  Glu 
    2360                 2365     


<210>  3
<211>  2710
<212>  PRT
<213>  Clostridium difficile

<400>  3

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile 
1               5                   10                  15      


Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu 
            20                  25                  30          


Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu 
        35                  40                  45              


Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn 
    50                  55                  60                  


Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys 
65                  70                  75                  80  


Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn 
                85                  90                  95      


Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu 
            100                 105                 110         


Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu 
        115                 120                 125             


Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile 
    130                 135                 140                 


Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile 
145                 150                 155                 160 


Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu 
                165                 170                 175     


Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln 
            180                 185                 190         


Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His 
        195                 200                 205             


Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg 
    210                 215                 220                 


Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg 
225                 230                 235                 240 


Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln 
                245                 250                 255     


Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg 
            260                 265                 270         


Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met 
        275                 280                 285             


Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser 
    290                 295                 300                 


Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met 
305                 310                 315                 320 


Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys 
                325                 330                 335     


Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys 
            340                 345                 350         


Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser 
        355                 360                 365             


Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln 
    370                 375                 380                 


Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu 
385                 390                 395                 400 


Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala 
                405                 410                 415     


Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp 
            420                 425                 430         


Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys 
        435                 440                 445             


Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr 
    450                 455                 460                 


Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe 
465                 470                 475                 480 


Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp 
                485                 490                 495     


Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu 
            500                 505                 510         


Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr 
        515                 520                 525             


Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu 
    530                 535                 540                 


Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr 
545                 550                 555                 560 


Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser 
                565                 570                 575     


Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser 
            580                 585                 590         


Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile 
        595                 600                 605             


Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser 
    610                 615                 620                 


Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu 
625                 630                 635                 640 


Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly 
                645                 650                 655     


Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser 
            660                 665                 670         


Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile 
        675                 680                 685             


Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser 
    690                 695                 700                 


Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser 
705                 710                 715                 720 


Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser 
                725                 730                 735     


Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly 
            740                 745                 750         


Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu 
        755                 760                 765             


Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser 
    770                 775                 780                 


Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala 
785                 790                 795                 800 


Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser 
                805                 810                 815     


Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser 
            820                 825                 830         


Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn 
        835                 840                 845             


Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu 
    850                 855                 860                 


Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu 
865                 870                 875                 880 


Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser 
                885                 890                 895     


Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr 
            900                 905                 910         


Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr 
        915                 920                 925             


Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly 
    930                 935                 940                 


Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr 
945                 950                 955                 960 


Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn 
                965                 970                 975     


Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr 
            980                 985                 990         


Ala Gln Leu Phe Ser Thr Gly Leu  Asn Thr Ile Tyr Asp  Ser Ile Gln 
        995                 1000                 1005             


Leu Val  Asn Leu Ile Ser Asn  Ala Val Asn Asp Thr  Ile Asn Val 
    1010                 1015                 1020             


Leu Pro  Thr Ile Thr Glu Gly  Ile Pro Ile Val Ser  Thr Ile Leu 
    1025                 1030                 1035             


Asp Gly  Ile Asn Leu Gly Ala  Ala Ile Lys Glu Leu  Leu Asp Glu 
    1040                 1045                 1050             


His Asp  Pro Leu Leu Lys Lys  Glu Leu Glu Ala Lys  Val Gly Val 
    1055                 1060                 1065             


Leu Ala  Ile Asn Met Ser Leu  Ser Ile Ala Ala Thr  Val Ala Ser 
    1070                 1075                 1080             


Ile Val  Gly Ile Gly Ala Glu  Val Thr Ile Phe Leu  Leu Pro Ile 
    1085                 1090                 1095             


Ala Gly  Ile Ser Ala Gly Ile  Pro Ser Leu Val Asn  Asn Glu Leu 
    1100                 1105                 1110             


Ile Leu  His Asp Lys Ala Thr  Ser Val Val Asn Tyr  Phe Asn His 
    1115                 1120                 1125             


Leu Ser  Glu Ser Lys Glu Tyr  Gly Pro Leu Lys Thr  Glu Asp Asp 
    1130                 1135                 1140             


Lys Ile  Leu Val Pro Ile Asp  Asp Leu Val Ile Ser  Glu Ile Asp 
    1145                 1150                 1155             


Phe Asn  Asn Asn Ser Ile Lys  Leu Gly Thr Cys Asn  Ile Leu Ala 
    1160                 1165                 1170             


Met Glu  Gly Gly Ser Gly His  Thr Val Thr Gly Asn  Ile Asp His 
    1175                 1180                 1185             


Phe Phe  Ser Ser Pro Tyr Ile  Ser Ser His Ile Pro  Ser Leu Ser 
    1190                 1195                 1200             


Val Tyr  Ser Ala Ile Gly Ile  Lys Thr Glu Asn Leu  Asp Phe Ser 
    1205                 1210                 1215             


Lys Lys  Ile Met Met Leu Pro  Asn Ala Pro Ser Arg  Val Phe Trp 
    1220                 1225                 1230             


Trp Glu  Thr Gly Ala Val Pro  Gly Leu Arg Ser Leu  Glu Asn Asn 
    1235                 1240                 1245             


Gly Thr  Lys Leu Leu Asp Ser  Ile Arg Asp Leu Tyr  Pro Gly Lys 
    1250                 1255                 1260             


Phe Tyr  Trp Arg Phe Tyr Ala  Phe Phe Asp Tyr Ala  Ile Thr Thr 
    1265                 1270                 1275             


Leu Lys  Pro Val Tyr Glu Asp  Thr Asn Thr Lys Ile  Lys Leu Asp 
    1280                 1285                 1290             


Lys Asp  Thr Arg Asn Phe Ile  Met Pro Thr Ile Thr  Thr Asp Glu 
    1295                 1300                 1305             


Ile Arg  Asn Lys Leu Ser Tyr  Ser Phe Asp Gly Ala  Gly Gly Thr 
    1310                 1315                 1320             


Tyr Ser  Leu Leu Leu Ser Ser  Tyr Pro Ile Ser Met  Asn Ile Asn 
    1325                 1330                 1335             


Leu Ser  Lys Asp Asp Leu Trp  Ile Phe Asn Ile Asp  Asn Glu Val 
    1340                 1345                 1350             


Arg Glu  Ile Ser Ile Glu Asn  Gly Thr Ile Lys Lys  Gly Asn Leu 
    1355                 1360                 1365             


Ile Glu  Asp Val Leu Ser Lys  Ile Asp Ile Asn Lys  Asn Lys Leu 
    1370                 1375                 1380             


Ile Ile  Gly Asn Gln Thr Ile  Asp Phe Ser Gly Asp  Ile Asp Asn 
    1385                 1390                 1395             


Lys Asp  Arg Tyr Ile Phe Leu  Thr Cys Glu Leu Asp  Asp Lys Ile 
    1400                 1405                 1410             


Ser Leu  Ile Ile Glu Ile Asn  Leu Val Ala Lys Ser  Tyr Ser Leu 
    1415                 1420                 1425             


Leu Leu  Ser Gly Asp Lys Asn  Tyr Leu Ile Ser Asn  Leu Ser Asn 
    1430                 1435                 1440             


Thr Ile  Glu Lys Ile Asn Thr  Leu Gly Leu Asp Ser  Lys Asn Ile 
    1445                 1450                 1455             


Ala Tyr  Asn Tyr Thr Asp Glu  Ser Asn Asn Lys Tyr  Phe Gly Ala 
    1460                 1465                 1470             


Ile Ser  Lys Thr Ser Gln Lys  Ser Ile Ile His Tyr  Lys Lys Asp 
    1475                 1480                 1485             


Ser Lys  Asn Ile Leu Glu Phe  Tyr Asn Gly Ser Thr  Leu Glu Phe 
    1490                 1495                 1500             


Asn Ser  Lys Asp Phe Ile Ala  Glu Asp Ile Asn Val  Phe Met Lys 
    1505                 1510                 1515             


Asp Asp  Ile Asn Thr Ile Thr  Gly Lys Tyr Tyr Val  Asp Asn Asn 
    1520                 1525                 1530             


Thr Asp  Lys Ser Ile Asp Phe  Ser Ile Ser Leu Val  Ser Lys Asn 
    1535                 1540                 1545             


Gln Val  Lys Val Asn Gly Leu  Tyr Leu Asn Glu Ser  Val Tyr Ser 
    1550                 1555                 1560             


Ser Tyr  Leu Asp Phe Val Lys  Asn Ser Asp Gly His  His Asn Thr 
    1565                 1570                 1575             


Ser Asn  Phe Met Asn Leu Phe  Leu Asn Asn Ile Ser  Phe Trp Lys 
    1580                 1585                 1590             


Leu Phe  Gly Phe Glu Asn Ile  Asn Phe Val Ile Asp  Lys Tyr Phe 
    1595                 1600                 1605             


Thr Leu  Val Gly Lys Thr Asn  Leu Gly Tyr Val Glu  Phe Ile Cys 
    1610                 1615                 1620             


Asp Asn  Asn Lys Asn Ile Asp  Ile Tyr Phe Gly Glu  Trp Lys Thr 
    1625                 1630                 1635             


Ser Ser  Ser Lys Ser Thr Ile  Phe Ser Gly Asn Gly  Arg Asn Val 
    1640                 1645                 1650             


Val Val  Glu Pro Ile Tyr Asn  Pro Asp Thr Gly Glu  Asp Ile Ser 
    1655                 1660                 1665             


Thr Ser  Leu Asp Phe Ser Tyr  Glu Pro Leu Tyr Gly  Ile Asp Arg 
    1670                 1675                 1680             


Tyr Ile  Asn Lys Val Leu Ile  Ala Pro Asp Leu Tyr  Thr Ser Leu 
    1685                 1690                 1695             


Ile Asn  Ile Asn Thr Asn Tyr  Tyr Ser Asn Glu Tyr  Tyr Pro Glu 
    1700                 1705                 1710             


Ile Ile  Val Leu Asn Pro Asn  Thr Phe His Lys Lys  Val Asn Ile 
    1715                 1720                 1725             


Asn Leu  Asp Ser Ser Ser Phe  Glu Tyr Lys Trp Ser  Thr Glu Gly 
    1730                 1735                 1740             


Ser Asp  Phe Ile Leu Val Arg  Tyr Leu Glu Glu Ser  Asn Lys Lys 
    1745                 1750                 1755             


Ile Leu  Gln Lys Ile Arg Ile  Lys Gly Ile Leu Ser  Asn Thr Gln 
    1760                 1765                 1770             


Ser Phe  Asn Lys Met Ser Ile  Asp Phe Lys Asp Ile  Lys Lys Leu 
    1775                 1780                 1785             


Ser Leu  Gly Tyr Ile Met Ser  Asn Phe Lys Ser Phe  Asn Ser Glu 
    1790                 1795                 1800             


Asn Glu  Leu Asp Arg Asp His  Leu Gly Phe Lys Ile  Ile Asp Asn 
    1805                 1810                 1815             


Lys Thr  Tyr Tyr Tyr Asp Glu  Asp Ser Lys Leu Val  Lys Gly Leu 
    1820                 1825                 1830             


Ile Asn  Ile Asn Asn Ser Leu  Phe Tyr Phe Asp Pro  Ile Glu Ser 
    1835                 1840                 1845             


Asn Leu  Val Thr Gly Trp Gln  Thr Ile Asn Gly Lys  Lys Tyr Tyr 
    1850                 1855                 1860             


Phe Asp  Ile Asn Thr Gly Ala  Ala Ser Thr Ser Tyr  Lys Ile Ile 
    1865                 1870                 1875             


Asn Gly  Lys His Phe Tyr Phe  Asn Asn Asn Gly Val  Met Gln Leu 
    1880                 1885                 1890             


Gly Val  Phe Lys Gly Pro Asp  Gly Phe Glu Tyr Phe  Ala Pro Ala 
    1895                 1900                 1905             


Asn Thr  Gln Asn Asn Asn Ile  Glu Gly Gln Ala Ile  Val Tyr Gln 
    1910                 1915                 1920             


Ser Lys  Phe Leu Thr Leu Asn  Gly Lys Lys Tyr Tyr  Phe Asp Asn 
    1925                 1930                 1935             


Asp Ser  Lys Ala Val Thr Gly  Trp Arg Ile Ile Asn  Asn Glu Lys 
    1940                 1945                 1950             


Tyr Tyr  Phe Asn Pro Asn Asn  Ala Ile Ala Ala Val  Gly Leu Gln 
    1955                 1960                 1965             


Val Ile  Asp Asn Asn Lys Tyr  Tyr Phe Asn Pro Asp  Thr Ala Ile 
    1970                 1975                 1980             


Ile Ser  Lys Gly Trp Gln Thr  Val Asn Gly Ser Arg  Tyr Tyr Phe 
    1985                 1990                 1995             


Asp Thr  Asp Thr Ala Ile Ala  Phe Asn Gly Tyr Lys  Thr Ile Asp 
    2000                 2005                 2010             


Gly Lys  His Phe Tyr Phe Asp  Ser Asp Cys Val Val  Lys Ile Gly 
    2015                 2020                 2025             


Val Phe  Ser Gly Ser Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn 
    2030                 2035                 2040             


Thr Tyr  Asn Asn Asn Ile Glu  Gly Gln Ala Ile Val  Tyr Gln Ser 
    2045                 2050                 2055             


Lys Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr Tyr Phe  Asp Asn Asn 
    2060                 2065                 2070             


Ser Lys  Ala Val Thr Gly Trp  Gln Thr Ile Asp Ser  Lys Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asn Thr Asn Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr 
    2090                 2095                 2100             


Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr Asn Thr  Ala Glu Ala 
    2105                 2110                 2115             


Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn 
    2120                 2125                 2130             


Thr Asn  Thr Ser Ile Ala Ser  Thr Gly Tyr Thr Ile  Ile Asn Gly 
    2135                 2140                 2145             


Lys Tyr  Phe Tyr Phe Asn Thr  Asp Gly Ile Met Gln  Ile Gly Val 
    2150                 2155                 2160             


Phe Lys  Val Pro Asn Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr 
    2165                 2170                 2175             


His Asn  Asn Asn Ile Glu Gly  Gln Ala Ile Leu Tyr  Gln Asn Lys 
    2180                 2185                 2190             


Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr Phe Gly  Ser Asp Ser 
    2195                 2200                 2205             


Lys Ala  Ile Thr Gly Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asn  Pro Asn Asn Ala Ile  Ala Ala Thr His Leu  Cys Thr Ile 
    2225                 2230                 2235             


Asn Asn  Asp Lys Tyr Tyr Phe  Ser Tyr Asp Gly Ile  Leu Gln Asn 
    2240                 2245                 2250             


Gly Tyr  Ile Thr Ile Glu Arg  Asn Asn Phe Tyr Phe  Asp Ala Asn 
    2255                 2260                 2265             


Asn Glu  Ser Lys Met Val Thr  Gly Val Phe Lys Gly  Pro Asn Gly 
    2270                 2275                 2280             


Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr His Asn Asn  Asn Ile Glu 
    2285                 2290                 2295             


Gly Gln  Ala Ile Val Tyr Gln  Asn Lys Phe Leu Thr  Leu Asn Gly 
    2300                 2305                 2310             


Lys Lys  Tyr Tyr Phe Asp Asn  Asp Ser Lys Ala Val  Thr Gly Trp 
    2315                 2320                 2325             


Gln Thr  Ile Asp Ser Lys Lys  Tyr Tyr Phe Asn Leu  Asn Thr Ala 
    2330                 2335                 2340             


Val Ala  Val Thr Gly Trp Gln  Thr Ile Asp Gly Glu  Lys Tyr Tyr 
    2345                 2350                 2355             


Phe Asn  Leu Asn Thr Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile 
    2360                 2365                 2370             


Asp Gly  Lys Arg Tyr Tyr Phe  Asn Thr Asn Thr Tyr  Ile Ala Ser 
    2375                 2380                 2385             


Thr Gly  Tyr Thr Ile Ile Asn  Gly Lys His Phe Tyr  Phe Asn Thr 
    2390                 2395                 2400             


Asp Gly  Ile Met Gln Ile Gly  Val Phe Lys Gly Pro  Asp Gly Phe 
    2405                 2410                 2415             


Glu Tyr  Phe Ala Pro Ala Asn  Thr His Asn Asn Asn  Ile Glu Gly 
    2420                 2425                 2430             


Gln Ala  Ile Leu Tyr Gln Asn  Lys Phe Leu Thr Leu  Asn Gly Lys 
    2435                 2440                 2445             


Lys Tyr  Tyr Phe Gly Ser Asp  Ser Lys Ala Val Thr  Gly Leu Arg 
    2450                 2455                 2460             


Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Val 
    2465                 2470                 2475             


Ala Val  Thr Gly Trp Gln Thr  Ile Asn Gly Lys Lys  Tyr Tyr Phe 
    2480                 2485                 2490             


Asn Thr  Asn Thr Tyr Ile Ala  Ser Thr Gly Tyr Thr  Ile Ile Ser 
    2495                 2500                 2505             


Gly Lys  His Phe Tyr Phe Asn  Thr Asp Gly Ile Met  Gln Ile Gly 
    2510                 2515                 2520             


Val Phe  Lys Gly Pro Asp Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn 
    2525                 2530                 2535             


Thr Asp  Ala Asn Asn Ile Glu  Gly Gln Ala Ile Arg  Tyr Gln Asn 
    2540                 2545                 2550             


Arg Phe  Leu Tyr Leu His Asp  Asn Ile Tyr Tyr Phe  Gly Asn Asp 
    2555                 2560                 2565             


Ser Lys  Ala Ala Thr Gly Trp  Ala Thr Ile Asp Gly  Asn Arg Tyr 
    2570                 2575                 2580             


Tyr Phe  Glu Pro Asn Thr Ala  Met Gly Ala Asn Gly  Tyr Lys Thr 
    2585                 2590                 2595             


Ile Asp  Asn Lys Asn Phe Tyr  Phe Arg Asn Gly Leu  Pro Gln Ile 
    2600                 2605                 2610             


Gly Val  Phe Lys Gly Pro Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala 
    2615                 2620                 2625             


Asn Thr  Asp Ala Asn Asn Ile  Asp Gly Gln Ala Ile  Arg Tyr Gln 
    2630                 2635                 2640             


Asn Arg  Phe Leu His Leu Leu  Gly Lys Ile Tyr Tyr  Phe Gly Asn 
    2645                 2650                 2655             


Asn Ser  Lys Ala Val Thr Gly  Trp Gln Thr Ile Asn  Ser Lys Val 
    2660                 2665                 2670             


Tyr Tyr  Phe Met Pro Asp Thr  Ala Met Ala Ala Ala  Gly Gly Leu 
    2675                 2680                 2685             


Phe Glu  Ile Asp Gly Val Ile  Tyr Phe Phe Gly Val  Asp Gly Val 
    2690                 2695                 2700             


Lys Ala  Pro Gly Ile Tyr Gly  
    2705                 2710 


<210>  4
<211>  2366
<212>  PRT
<213>  Clostridium difficile

<400>  4

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Ile Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met 
                165                 170                 175     


Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Ala Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly 
    530                 535                 540                 


Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu 
545                 550                 555                 560 


Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
                565                 570                 575     


Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         


Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe 
        595                 600                 605             


Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly 
    610                 615                 620                 


Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile 
625                 630                 635                 640 


Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp 
                645                 650                 655     


Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser 
            660                 665                 670         


Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro 
        675                 680                 685             


Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 


Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys 
705                 710                 715                 720 


Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     


Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         


Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             


Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu 
    770                 775                 780                 


Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 


Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu 
                805                 810                 815     


Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile 
            820                 825                 830         


Asp Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr 
        835                 840                 845             


Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 


Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu 
865                 870                 875                 880 


Ser His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe 
                885                 890                 895     


Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         


Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu 
        915                 920                 925             


Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 


Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 


Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu 
                965                 970                 975     


Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         


Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val 
        995                 1000                 1005             


Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro 
    1010                 1015                 1020             


Thr Leu  Ser Glu Gly Leu Pro  Val Ile Ala Thr Ile  Ile Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Gly Ala Ala Ile  Lys Glu Leu Ser Glu  Thr Ser Asp 
    1040                 1045                 1050             


Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala 
    1055                 1060                 1065             


Val Asn  Leu Thr Ala Ala Thr  Thr Ala Ile Ile Thr  Ser Ser Leu 
    1070                 1075                 1080             


Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly 
    1085                 1090                 1095             


Ile Ser  Ala Gly Ile Pro Ser  Leu Val Asn Asn Glu  Leu Ile Leu 
    1100                 1105                 1110             


Arg Asp  Lys Ala Thr Lys Val  Val Asp Tyr Phe Ser  His Ile Ser 
    1115                 1120                 1125             


Leu Ala  Glu Ser Glu Gly Ala  Phe Thr Ser Leu Asp  Asp Lys Ile 
    1130                 1135                 1140             


Met Met  Pro Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn 
    1145                 1150                 1155             


Asn Asn  Ser Ile Thr Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu 
    1160                 1165                 1170             


Gly Gly  Ser Gly His Thr Val  Thr Asp Asp Ile Asp  His Phe Phe 
    1175                 1180                 1185             


Ser Ala  Pro Ser Ile Thr Tyr  Arg Glu Pro His Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Asp Val  Leu Glu Val Gln Lys  Glu Glu Leu Asp Leu  Ser Lys Asp 
    1205                 1210                 1215             


Leu Met  Val Leu Pro Asn Ala  Pro Asn Arg Val Phe  Ala Trp Glu 
    1220                 1225                 1230             


Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu Glu Asn  Asp Gly Thr 
    1235                 1240                 1245             


Lys Leu  Leu Asp Arg Ile Arg  Asp Asn Tyr Glu Gly  Glu Phe Tyr 
    1250                 1255                 1260             


Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala Leu Ile  Thr Thr Leu 
    1265                 1270                 1275             


Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg Ile Asn  Leu Asp Ser 
    1280                 1285                 1290             


Asn Thr  Arg Ser Phe Ile Val  Pro Val Ile Thr Thr  Glu Tyr Ile 
    1295                 1300                 1305             


Arg Glu  Lys Leu Ser Tyr Ser  Phe Tyr Gly Ser Gly  Gly Thr Tyr 
    1310                 1315                 1320             


Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Asn Ile Asn  Ile Glu Leu 
    1325                 1330                 1335             


Asn Glu  Asn Asp Thr Trp Val  Ile Asp Val Asp Asn  Val Val Arg 
    1340                 1345                 1350             


Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile 
    1355                 1360                 1365             


Glu Asn  Ile Leu Ser Lys Leu  Ser Ile Glu Asp Asn  Lys Ile Ile 
    1370                 1375                 1380             


Leu Asp  Asn His Glu Ile Asn  Phe Ser Gly Thr Leu  Asn Gly Gly 
    1385                 1390                 1395             


Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ile Glu Val Asp Leu  Leu Ser Lys Ser Tyr  Lys Val Leu 
    1415                 1420                 1425             


Ile Ser  Gly Glu Leu Lys Thr  Leu Met Ala Asn Ser  Asn Ser Val 
    1430                 1435                 1440             


Gln Gln  Lys Ile Asp Tyr Ile  Gly Leu Asn Ser Glu  Leu Gln Lys 
    1445                 1450                 1455             


Asn Ile  Pro Tyr Ser Phe Met  Asp Asp Lys Gly Lys  Glu Asn Gly 
    1460                 1465                 1470             


Phe Ile  Asn Cys Ser Thr Lys  Glu Gly Leu Phe Val  Ser Glu Leu 
    1475                 1480                 1485             


Ser Asp  Val Val Leu Ile Ser  Lys Val Tyr Met Asp  Asn Ser Lys 
    1490                 1495                 1500             


Pro Leu  Phe Gly Tyr Cys Ser  Asn Asp Leu Lys Asp  Val Lys Val 
    1505                 1510                 1515             


Ile Thr  Lys Asp Asp Val Ile  Ile Leu Thr Gly Tyr  Tyr Leu Lys 
    1520                 1525                 1530             


Asp Asp  Ile Lys Ile Ser Leu  Ser Phe Thr Ile Gln  Asp Glu Asn 
    1535                 1540                 1545             


Thr Ile  Lys Leu Asn Gly Val  Tyr Leu Asp Glu Asn  Gly Val Ala 
    1550                 1555                 1560             


Glu Ile  Leu Lys Phe Met Asn  Lys Lys Gly Ser Thr  Asn Thr Ser 
    1565                 1570                 1575             


Asp Ser  Leu Met Ser Phe Leu  Glu Ser Met Asn Ile  Lys Ser Ile 
    1580                 1585                 1590             


Phe Ile  Asn Ser Leu Gln Ser  Asn Thr Lys Leu Ile  Leu Asp Thr 
    1595                 1600                 1605             


Asn Phe  Ile Ile Ser Gly Thr  Thr Ser Ile Gly Gln  Phe Glu Phe 
    1610                 1615                 1620             


Ile Cys  Asp Lys Asp Asn Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe 
    1625                 1630                 1635             


Asn Thr  Leu Glu Thr Lys Tyr  Thr Leu Tyr Val Gly  Asn Arg Gln 
    1640                 1645                 1650             


Asn Met  Ile Val Glu Pro Asn  Tyr Asp Leu Asp Asp  Ser Gly Asp 
    1655                 1660                 1665             


Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly 
    1670                 1675                 1680             


Ile Asp  Ser Cys Val Asn Lys  Val Ile Ile Ser Pro  Asn Ile Tyr 
    1685                 1690                 1695             


Thr Asp  Glu Ile Asn Ile Thr  Pro Ile Tyr Glu Ala  Asn Asn Thr 
    1700                 1705                 1710             


Tyr Pro  Glu Val Ile Val Leu  Asp Thr Asn Tyr Ile  Ser Glu Lys 
    1715                 1720                 1725             


Ile Asn  Ile Asn Ile Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser 
    1730                 1735                 1740             


Asn Asp  Gly Ser Asp Phe Ile  Leu Met Ser Thr Asp  Glu Glu Asn 
    1745                 1750                 1755             


Lys Val  Ser Gln Val Lys Ile  Arg Phe Thr Asn Val  Phe Lys Gly 
    1760                 1765                 1770             


Asn Thr  Ile Ser Asp Lys Ile  Ser Phe Asn Phe Ser  Asp Lys Gln 
    1775                 1780                 1785             


Asp Val  Ser Ile Asn Lys Val  Ile Ser Thr Phe Thr  Pro Ser Tyr 
    1790                 1795                 1800             


Tyr Val  Glu Gly Leu Leu Asn  Tyr Asp Leu Gly Leu  Ile Ser Leu 
    1805                 1810                 1815             


Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser 
    1820                 1825                 1830             


Gly Leu  Val Tyr Ile Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro 
    1835                 1840                 1845             


Ile Lys  Asn Leu Ile Thr Gly  Phe Thr Thr Ile Gly  Asp Asp Lys 
    1850                 1855                 1860             


Tyr Tyr  Phe Asn Pro Asp Asn  Gly Gly Ala Ala Ser  Val Gly Glu 
    1865                 1870                 1875             


Thr Ile  Ile Asp Gly Lys Asn  Tyr Tyr Phe Ser Gln  Asn Gly Val 
    1880                 1885                 1890             


Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1895                 1900                 1905             


Ala Pro  Ala Asp Thr Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile 
    1910                 1915                 1920             


Asp Phe  Thr Gly Lys Leu Thr  Ile Asp Glu Asn Val  Tyr Tyr Phe 
    1925                 1930                 1935             


Gly Asp  Asn Tyr Arg Ala Ala  Ile Glu Trp Gln Thr  Leu Asp Asp 
    1940                 1945                 1950             


Glu Val  Tyr Tyr Phe Ser Thr  Asp Thr Gly Arg Ala  Phe Lys Gly 
    1955                 1960                 1965             


Leu Asn  Gln Ile Gly Asp Asp  Lys Phe Tyr Phe Asn  Ser Asp Gly 
    1970                 1975                 1980             


Ile Met  Gln Lys Gly Phe Val  Asn Ile Asn Asp Lys  Thr Phe Tyr 
    1985                 1990                 1995             


Phe Asp  Asp Ser Gly Val Met  Lys Ser Gly Tyr Thr  Glu Ile Asp 
    2000                 2005                 2010             


Gly Lys  Tyr Phe Tyr Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly 
    2015                 2020                 2025             


Val Phe  Asn Thr Ala Asp Gly  Phe Lys Tyr Phe Ala  His His Asp 
    2030                 2035                 2040             


Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Ala Leu Ser  Tyr Ser Gly 
    2045                 2050                 2055             


Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe 
    2060                 2065                 2070             


Thr Ala  Val Val Gly Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asp Glu Asp Thr Ala  Glu Ala Tyr Ile Gly  Ile Ser Ile 
    2090                 2095                 2100             


Ile Asn  Asp Gly Lys Tyr Tyr  Phe Asn Asp Ser Gly  Ile Met Gln 
    2105                 2110                 2115             


Ile Gly  Phe Val Thr Ile Asn  Asn Glu Val Phe Tyr  Phe Ser Asp 
    2120                 2125                 2130             


Ser Gly  Ile Val Glu Ser Gly  Met Gln Asn Ile Asp  Asp Asn Tyr 
    2135                 2140                 2145             


Phe Tyr  Ile Asp Glu Asn Gly  Leu Val Gln Ile Gly  Val Phe Asp 
    2150                 2155                 2160             


Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn 
    2165                 2170                 2175             


Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr Ser Gly  Leu Val Arg 
    2180                 2185                 2190             


Val Gly  Glu Asp Val Tyr Tyr  Phe Gly Glu Thr Tyr  Thr Ile Glu 
    2195                 2200                 2205             


Thr Gly  Trp Ile Tyr Asp Met  Glu Asn Glu Ser Asp  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asp  Pro Glu Thr Lys Lys  Ala Tyr Lys Gly Ile  Asn Val Ile 
    2225                 2230                 2235             


Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Asn Gly Ile  Met Arg Thr 
    2240                 2245                 2250             


Gly Leu  Ile Thr Phe Glu Asp  Asn His Tyr Tyr Phe  Asn Glu Asp 
    2255                 2260                 2265             


Gly Ile  Met Gln Tyr Gly Tyr  Leu Asn Ile Glu Asp  Lys Thr Phe 
    2270                 2275                 2280             


Tyr Phe  Ser Glu Asp Gly Ile  Met Gln Ile Gly Val  Phe Asn Thr 
    2285                 2290                 2295             


Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln Asn Thr  Leu Asp Glu 
    2300                 2305                 2310             


Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu 
    2315                 2320                 2325             


Asp Glu  Lys Arg Tyr Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr 
    2330                 2335                 2340             


Gly Ser  Val Ile Ile Asp Gly  Glu Glu Tyr Tyr Phe  Asp Pro Asp 
    2345                 2350                 2355             


Thr Ala  Gln Leu Val Ile Ser  Glu 
    2360                 2365     


<210>  5
<211>  1580
<212>  PRT
<213>  Clostridium difficile

<400>  5

Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu 
1               5                   10                  15      


Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn 
            20                  25                  30          


Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met Glu Gly Gly Ser 
        35                  40                  45              


Gly His Thr Val Thr Gly Asn Ile Asp His Phe Phe Ser Ser Pro Ser 
    50                  55                  60                  


Ile Ser Ser His Ile Pro Ser Leu Ser Ile Tyr Ser Ala Ile Gly Ile 
65                  70                  75                  80  


Glu Thr Glu Asn Leu Asp Phe Ser Lys Lys Ile Met Met Leu Pro Asn 
                85                  90                  95      


Ala Pro Ser Arg Val Phe Trp Trp Glu Thr Gly Ala Val Pro Gly Leu 
            100                 105                 110         


Arg Ser Leu Glu Asn Asp Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp 
        115                 120                 125             


Leu Tyr Pro Gly Lys Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr 
    130                 135                 140                 


Ala Ile Thr Thr Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile 
145                 150                 155                 160 


Lys Leu Asp Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr 
                165                 170                 175     


Asn Glu Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly 
            180                 185                 190         


Thr Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn 
        195                 200                 205             


Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg 
    210                 215                 220                 


Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile Lys 
225                 230                 235                 240 


Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile Ile Gly 
                245                 250                 255     


Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys Asp Arg Tyr 
            260                 265                 270         


Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser Leu Ile Ile Glu 
        275                 280                 285             


Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu Leu Ser Gly Asp Lys 
    290                 295                 300                 


Asn Tyr Leu Ile Ser Asn Leu Ser Asn Ile Ile Glu Lys Ile Asn Thr 
305                 310                 315                 320 


Leu Gly Leu Asp Ser Lys Asn Ile Ala Tyr Asn Tyr Thr Asp Glu Ser 
                325                 330                 335     


Asn Asn Lys Tyr Phe Gly Ala Ile Ser Lys Thr Ser Gln Lys Ser Ile 
            340                 345                 350         


Ile His Tyr Lys Lys Asp Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp 
        355                 360                 365             


Ser Thr Leu Glu Phe Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn 
    370                 375                 380                 


Val Phe Met Lys Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val 
385                 390                 395                 400 


Asp Asn Asn Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser 
                405                 410                 415     


Lys Asn Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr 
            420                 425                 430         


Ser Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr 
        435                 440                 445             


Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu 
    450                 455                 460                 


Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr Leu 
465                 470                 475                 480 


Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp Asn Asn 
                485                 490                 495     


Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser Ser Ser Lys 
            500                 505                 510         


Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val Val Glu Pro Ile 
        515                 520                 525             


Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr Ser Leu Asp Phe Ser 
    530                 535                 540                 


Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr Ile Asn Lys Val Leu Ile 
545                 550                 555                 560 


Ala Pro Asp Leu Tyr Thr Ser Leu Ile Asn Ile Asn Thr Asn Tyr Tyr 
                565                 570                 575     


Ser Asn Glu Tyr Tyr Pro Glu Ile Ile Val Leu Asn Pro Asn Thr Phe 
            580                 585                 590         


His Lys Lys Val Asn Ile Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys 
        595                 600                 605             


Trp Ser Thr Glu Gly Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu 
    610                 615                 620                 


Ser Asn Lys Lys Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser 
625                 630                 635                 640 


Asn Thr Gln Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys 
                645                 650                 655     


Lys Leu Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser 
            660                 665                 670         


Glu Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn 
        675                 680                 685             


Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile 
    690                 695                 700                 


Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn Leu 
705                 710                 715                 720 


Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile 
                725                 730                 735     


Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile Asn Gly Lys His 
            740                 745                 750         


Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly Val Phe Lys Gly 
        755                 760                 765             


Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Gln Asn Asn Asn 
    770                 775                 780                 


Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn 
785                 790                 795                 800 


Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp 
                805                 810                 815     


Arg Ile Ile Asn Asn Glu Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile 
            820                 825                 830         


Ala Ala Val Gly Leu Gln Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn 
        835                 840                 845             


Pro Asp Thr Ala Ile Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser 
    850                 855                 860                 


Arg Tyr Tyr Phe Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys 
865                 870                 875                 880 


Thr Ile Asp Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys 
                885                 890                 895     


Ile Gly Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala 
            900                 905                 910         


Asn Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser 
        915                 920                 925             


Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser 
    930                 935                 940                 


Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe 
945                 950                 955                 960 


Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly 
                965                 970                 975     


Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp 
            980                 985                 990         


Gln Thr Ile Asp Gly Lys Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Ile 
        995                 1000                 1005             


Ala Ser  Thr Gly Tyr Thr Ile  Ile Asn Gly Lys His  Phe Tyr Phe 
    1010                 1015                 1020             


Asn Thr  Asp Gly Ile Met Gln  Ile Gly Val Phe Lys  Gly Pro Asn 
    1025                 1030                 1035             


Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr Asp Ala  Asn Asn Ile 
    1040                 1045                 1050             


Glu Gly  Gln Ala Ile Leu Tyr  Gln Asn Glu Phe Leu  Thr Leu Asn 
    1055                 1060                 1065             


Gly Lys  Lys Tyr Tyr Phe Gly  Ser Asp Ser Lys Ala  Val Thr Gly 
    1070                 1075                 1080             


Trp Arg  Ile Ile Asn Asn Lys  Lys Tyr Tyr Phe Asn  Pro Asn Asn 
    1085                 1090                 1095             


Ala Ile  Ala Ala Ile His Leu  Cys Thr Ile Asn Asn  Asp Lys Tyr 
    1100                 1105                 1110             


Tyr Phe  Ser Tyr Asp Gly Ile  Leu Gln Asn Gly Tyr  Ile Thr Ile 
    1115                 1120                 1125             


Glu Arg  Asn Asn Phe Tyr Phe  Asp Ala Asn Asn Glu  Ser Lys Met 
    1130                 1135                 1140             


Val Thr  Gly Val Phe Lys Gly  Pro Asn Gly Phe Glu  Tyr Phe Ala 
    1145                 1150                 1155             


Pro Ala  Asn Thr His Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Val 
    1160                 1165                 1170             


Tyr Gln  Asn Lys Phe Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe 
    1175                 1180                 1185             


Asp Asn  Asp Ser Lys Ala Val  Thr Gly Trp Gln Thr  Ile Asp Gly 
    1190                 1195                 1200             


Lys Lys  Tyr Tyr Phe Asn Leu  Asn Thr Ala Glu Ala  Ala Thr Gly 
    1205                 1210                 1215             


Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr Phe Asn  Leu Asn Thr 
    1220                 1225                 1230             


Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr 
    1235                 1240                 1245             


Tyr Phe  Asn Thr Asn Thr Phe  Ile Ala Ser Thr Gly  Tyr Thr Ser 
    1250                 1255                 1260             


Ile Asn  Gly Lys His Phe Tyr  Phe Asn Thr Asp Gly  Ile Met Gln 
    1265                 1270                 1275             


Ile Gly  Val Phe Lys Gly Pro  Asn Gly Phe Glu Tyr  Phe Ala Pro 
    1280                 1285                 1290             


Ala Asn  Thr His Asn Asn Asn  Ile Glu Gly Gln Ala  Ile Leu Tyr 
    1295                 1300                 1305             


Gln Asn  Lys Phe Leu Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Gly 
    1310                 1315                 1320             


Ser Asp  Ser Lys Ala Val Thr  Gly Leu Arg Thr Ile  Asp Gly Lys 
    1325                 1330                 1335             


Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Val Ala Val  Thr Gly Trp 
    1340                 1345                 1350             


Gln Thr  Ile Asn Gly Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ser 
    1355                 1360                 1365             


Ile Ala  Ser Thr Gly Tyr Thr  Ile Ile Ser Gly Lys  His Phe Tyr 
    1370                 1375                 1380             


Phe Asn  Thr Asp Gly Ile Met  Gln Ile Gly Val Phe  Lys Gly Pro 
    1385                 1390                 1395             


Asp Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn Thr Asp  Ala Asn Asn 
    1400                 1405                 1410             


Ile Glu  Gly Gln Ala Ile Arg  Tyr Gln Asn Arg Phe  Leu Tyr Leu 
    1415                 1420                 1425             


His Asp  Asn Ile Tyr Tyr Phe  Gly Asn Asn Ser Lys  Ala Ala Thr 
    1430                 1435                 1440             


Gly Trp  Val Thr Ile Asp Gly  Asn Arg Tyr Tyr Phe  Glu Pro Asn 
    1445                 1450                 1455             


Thr Ala  Met Gly Ala Asn Gly  Tyr Lys Thr Ile Asp  Asn Lys Asn 
    1460                 1465                 1470             


Phe Tyr  Phe Arg Asn Gly Leu  Pro Gln Ile Gly Val  Phe Lys Gly 
    1475                 1480                 1485             


Ser Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  Asp Ala Asn 
    1490                 1495                 1500             


Asn Ile  Glu Gly Gln Ala Ile  Arg Tyr Gln Asn Arg  Phe Leu His 
    1505                 1510                 1515             


Leu Leu  Gly Lys Ile Tyr Tyr  Phe Gly Asn Asn Ser  Lys Ala Val 
    1520                 1525                 1530             


Thr Gly  Trp Gln Thr Ile Asn  Gly Lys Val Tyr Tyr  Phe Met Pro 
    1535                 1540                 1545             


Asp Thr  Ala Met Ala Ala Ala  Gly Gly Leu Phe Glu  Ile Asp Gly 
    1550                 1555                 1560             


Val Ile  Tyr Phe Phe Gly Val  Asp Gly Val Lys Ala  Pro Gly Ile 
    1565                 1570                 1575             


Tyr Gly  
    1580 


<210>  6
<211>  1580
<212>  PRT
<213>  Clostridium difficile

<400>  6

Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu 
1               5                   10                  15      


Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn 
            20                  25                  30          


Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met Glu Gly Gly Ser 
        35                  40                  45              


Gly His Thr Val Thr Gly Asn Ile Asp His Phe Phe Ser Ser Pro Ser 
    50                  55                  60                  


Ile Ser Ser His Ile Pro Ser Leu Ser Ile Tyr Ser Ala Ile Gly Ile 
65                  70                  75                  80  


Glu Thr Glu Asn Leu Asp Phe Ser Lys Lys Ile Met Met Leu Pro Asn 
                85                  90                  95      


Ala Pro Ser Arg Val Phe Trp Trp Glu Thr Gly Ala Val Pro Gly Leu 
            100                 105                 110         


Arg Ser Leu Glu Asn Asp Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp 
        115                 120                 125             


Leu Tyr Pro Gly Lys Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr 
    130                 135                 140                 


Ala Ile Thr Thr Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile 
145                 150                 155                 160 


Lys Leu Asp Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr 
                165                 170                 175     


Asn Glu Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly 
            180                 185                 190         


Thr Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn 
        195                 200                 205             


Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg 
    210                 215                 220                 


Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile Lys 
225                 230                 235                 240 


Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile Ile Gly 
                245                 250                 255     


Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys Asp Arg Tyr 
            260                 265                 270         


Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser Leu Ile Ile Glu 
        275                 280                 285             


Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu Leu Ser Gly Asp Lys 
    290                 295                 300                 


Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr Ile Glu Lys Ile Asn Thr 
305                 310                 315                 320 


Leu Gly Leu Asp Ser Lys Asn Ile Ala Tyr Asn Tyr Thr Asp Glu Ser 
                325                 330                 335     


Asn Asn Lys Tyr Phe Gly Ala Ile Ser Lys Thr Ser Gln Lys Ser Ile 
            340                 345                 350         


Ile His Tyr Lys Lys Asp Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp 
        355                 360                 365             


Ser Thr Leu Glu Phe Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn 
    370                 375                 380                 


Val Phe Met Lys Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val 
385                 390                 395                 400 


Asp Asn Asn Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser 
                405                 410                 415     


Lys Asn Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr 
            420                 425                 430         


Ser Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr 
        435                 440                 445             


Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu 
    450                 455                 460                 


Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr Leu 
465                 470                 475                 480 


Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp Asn Asn 
                485                 490                 495     


Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser Ser Ser Lys 
            500                 505                 510         


Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val Val Glu Pro Ile 
        515                 520                 525             


Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr Ser Leu Asp Phe Ser 
    530                 535                 540                 


Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr Ile Asn Lys Val Leu Ile 
545                 550                 555                 560 


Ala Pro Asp Leu Tyr Thr Ser Leu Ile Asn Ile Asn Thr Asn Tyr Tyr 
                565                 570                 575     


Ser Asn Glu Tyr Tyr Pro Glu Ile Ile Val Leu Asn Pro Asn Thr Phe 
            580                 585                 590         


His Lys Lys Val Asn Ile Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys 
        595                 600                 605             


Trp Ser Thr Glu Gly Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu 
    610                 615                 620                 


Ser Asn Lys Lys Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser 
625                 630                 635                 640 


Asn Thr Gln Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys 
                645                 650                 655     


Lys Leu Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser 
            660                 665                 670         


Glu Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn 
        675                 680                 685             


Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile 
    690                 695                 700                 


Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn Leu 
705                 710                 715                 720 


Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile 
                725                 730                 735     


Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn Gly Lys His 
            740                 745                 750         


Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly Val Phe Lys Gly 
        755                 760                 765             


Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Gln Asn Asn Asn 
    770                 775                 780                 


Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn 
785                 790                 795                 800 


Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Trp 
                805                 810                 815     


Arg Ile Ile Asn Asn Glu Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile 
            820                 825                 830         


Ala Ala Val Gly Leu Gln Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn 
        835                 840                 845             


Pro Asp Thr Ala Ile Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser 
    850                 855                 860                 


Arg Tyr Tyr Phe Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys 
865                 870                 875                 880 


Thr Ile Asp Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys 
                885                 890                 895     


Ile Gly Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala 
            900                 905                 910         


Asn Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser 
        915                 920                 925             


Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser 
    930                 935                 940                 


Lys Ala Val Thr Gly Leu Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe 
945                 950                 955                 960 


Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly 
                965                 970                 975     


Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp 
            980                 985                 990         


Gln Thr Ile Asp Gly Lys Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Ile 
        995                 1000                 1005             


Ala Ser  Thr Gly Tyr Thr Ile  Ile Asn Gly Lys His  Phe Tyr Phe 
    1010                 1015                 1020             


Asn Thr  Asp Gly Ile Met Gln  Ile Gly Val Phe Lys  Gly Pro Asn 
    1025                 1030                 1035             


Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr Asp Ala  Asn Asn Ile 
    1040                 1045                 1050             


Glu Gly  Gln Ala Ile Leu Tyr  Gln Asn Glu Phe Leu  Thr Leu Asn 
    1055                 1060                 1065             


Gly Lys  Lys Tyr Tyr Phe Gly  Ser Asp Ser Lys Ala  Val Thr Gly 
    1070                 1075                 1080             


Trp Arg  Ile Ile Asn Asn Lys  Lys Tyr Tyr Phe Asn  Pro Asn Asn 
    1085                 1090                 1095             


Ala Ile  Ala Ala Ile His Leu  Cys Thr Ile Asn Asn  Asp Lys Tyr 
    1100                 1105                 1110             


Tyr Phe  Ser Tyr Asp Gly Ile  Leu Gln Asn Gly Tyr  Ile Thr Ile 
    1115                 1120                 1125             


Glu Arg  Asn Asn Phe Tyr Phe  Asp Ala Asn Asn Glu  Ser Lys Met 
    1130                 1135                 1140             


Val Thr  Gly Val Phe Lys Gly  Pro Asn Gly Phe Glu  Tyr Phe Ala 
    1145                 1150                 1155             


Pro Ala  Asn Thr His Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Val 
    1160                 1165                 1170             


Tyr Gln  Asn Lys Phe Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe 
    1175                 1180                 1185             


Asp Asn  Asp Ser Lys Ala Val  Thr Gly Trp Gln Thr  Ile Asp Gly 
    1190                 1195                 1200             


Lys Lys  Tyr Tyr Phe Asn Leu  Asn Thr Ala Glu Ala  Ala Thr Gly 
    1205                 1210                 1215             


Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr Phe Asn  Leu Asn Thr 
    1220                 1225                 1230             


Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr 
    1235                 1240                 1245             


Tyr Phe  Asn Thr Asn Thr Phe  Ile Ala Ser Thr Gly  Tyr Thr Ser 
    1250                 1255                 1260             


Ile Asn  Gly Lys His Phe Tyr  Phe Asn Thr Asp Gly  Ile Met Gln 
    1265                 1270                 1275             


Ile Gly  Val Phe Lys Gly Pro  Asn Gly Phe Glu Tyr  Phe Ala Pro 
    1280                 1285                 1290             


Ala Asn  Thr Asp Ala Asn Asn  Ile Glu Gly Gln Ala  Ile Leu Tyr 
    1295                 1300                 1305             


Gln Asn  Lys Phe Leu Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Gly 
    1310                 1315                 1320             


Ser Asp  Ser Lys Ala Val Thr  Gly Leu Arg Thr Ile  Asp Gly Lys 
    1325                 1330                 1335             


Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Val Ala Val  Thr Gly Trp 
    1340                 1345                 1350             


Gln Thr  Ile Asn Gly Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ser 
    1355                 1360                 1365             


Ile Ala  Ser Thr Gly Tyr Thr  Ile Ile Ser Gly Lys  His Phe Tyr 
    1370                 1375                 1380             


Phe Asn  Thr Asp Gly Ile Met  Gln Ile Gly Val Phe  Lys Gly Pro 
    1385                 1390                 1395             


Asp Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn Thr Asp  Ala Asn Asn 
    1400                 1405                 1410             


Ile Glu  Gly Gln Ala Ile Arg  Tyr Gln Asn Arg Phe  Leu Tyr Leu 
    1415                 1420                 1425             


His Asp  Asn Ile Tyr Tyr Phe  Gly Asn Asn Ser Lys  Ala Ala Thr 
    1430                 1435                 1440             


Gly Trp  Val Thr Ile Asp Gly  Asn Arg Tyr Tyr Phe  Glu Pro Asn 
    1445                 1450                 1455             


Thr Ala  Met Gly Ala Asn Gly  Tyr Lys Thr Ile Asp  Asn Lys Asn 
    1460                 1465                 1470             


Phe Tyr  Phe Arg Asn Gly Leu  Pro Gln Ile Gly Val  Phe Lys Gly 
    1475                 1480                 1485             


Ser Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  Asp Ala Asn 
    1490                 1495                 1500             


Asn Ile  Glu Gly Gln Ala Ile  Arg Tyr Gln Asn Arg  Phe Leu His 
    1505                 1510                 1515             


Leu Leu  Gly Lys Ile Tyr Tyr  Phe Gly Asn Asn Ser  Lys Ala Val 
    1520                 1525                 1530             


Thr Gly  Trp Gln Thr Ile Asn  Gly Lys Val Tyr Tyr  Phe Met Pro 
    1535                 1540                 1545             


Asp Thr  Ala Met Ala Ala Ala  Gly Gly Leu Phe Glu  Ile Asp Gly 
    1550                 1555                 1560             


Val Ile  Tyr Phe Phe Gly Val  Asp Gly Val Lys Ala  Pro Gly Ile 
    1565                 1570                 1575             


Tyr Gly  
    1580 


<210>  7
<211>  1941
<212>  PRT
<213>  Clostridium difficile

<400>  7

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile 
1               5                   10                  15      


Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser 
            20                  25                  30          


Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro 
        35                  40                  45              


Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser 
    50                  55                  60                  


Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile 
65                  70                  75                  80  


Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu 
                85                  90                  95      


Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp 
            100                 105                 110         


Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr 
        115                 120                 125             


Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val 
    130                 135                 140                 


Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys 
145                 150                 155                 160 


Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn 
                165                 170                 175     


Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu 
            180                 185                 190         


Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys 
        195                 200                 205             


Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala 
    210                 215                 220                 


Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu 
225                 230                 235                 240 


Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu Pro 
                245                 250                 255     


Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp Gly Ile 
            260                 265                 270         


Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His Asp Pro Leu 
        275                 280                 285             


Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala Ile Asn Met 
    290                 295                 300                 


Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly Ile Gly Ala 
305                 310                 315                 320 


Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser Ala Gly Ile 
                325                 330                 335     


Pro Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys Ala Thr Ser 
            340                 345                 350         


Val Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Lys Tyr Gly Pro 
        355                 360                 365             


Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu Val 
    370                 375                 380                 


Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys 
385                 390                 395                 400 


Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn 
                405                 410                 415     


Ile Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser 
            420                 425                 430         


Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe 
        435                 440                 445             


Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp 
    450                 455                 460                 


Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly 
465                 470                 475                 480 


Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr 
                485                 490                 495     


Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys Pro 
            500                 505                 510         


Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp Thr Arg 
        515                 520                 525             


Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg Asn Lys Leu 
    530                 535                 540                 


Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu Ser 
545                 550                 555                 560 


Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp Asp Leu Trp 
                565                 570                 575     


Ile Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn Gly 
            580                 585                 590         


Thr Ile Lys Lys Gly Lys Leu Ile Lys Asp Val Leu Ser Lys Ile Asp 
        595                 600                 605             


Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser 
    610                 615                 620                 


Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu 
625                 630                 635                 640 


Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser 
                645                 650                 655     


Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu 
            660                 665                 670         


Ser Asn Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn 
        675                 680                 685             


Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala 
    690                 695                 700                 


Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser 
705                 710                 715                 720 


Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn Ser 
                725                 730                 735     


Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp Ile 
            740                 745                 750         


Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser 
        755                 760                 765             


Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val Asn 
    770                 775                 780                 


Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val 
785                 790                 795                 800 


Lys Asn Ser Asp Gly His His Asn Thr Ser Asn Phe Met Asn Leu Phe 
                805                 810                 815     


Leu Asp Asn Ile Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile Asn 
            820                 825                 830         


Phe Val Ile Asp Lys Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu Gly 
        835                 840                 845             


Tyr Val Glu Phe Ile Cys Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe 
    850                 855                 860                 


Gly Glu Trp Lys Thr Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn 
865                 870                 875                 880 


Gly Arg Asn Val Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu 
                885                 890                 895     


Asp Ile Ser Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile 
            900                 905                 910         


Asp Arg Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser 
        915                 920                 925             


Leu Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu 
    930                 935                 940                 


Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn 
945                 950                 955                 960 


Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser Asp 
                965                 970                 975     


Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu Gln 
            980                 985                 990         


Lys Ile Arg Ile Lys Gly Ile Leu  Ser Asn Thr Gln Ser  Phe Asn Lys 
        995                 1000                 1005             


Met Ser  Ile Asp Phe Lys Asp  Ile Lys Lys Leu Ser  Leu Gly Tyr 
    1010                 1015                 1020             


Ile Met  Ser Asn Phe Lys Ser  Phe Asn Ser Glu Asn  Glu Leu Asp 
    1025                 1030                 1035             


Arg Asp  His Leu Gly Phe Lys  Ile Ile Asp Asn Lys  Thr Tyr Tyr 
    1040                 1045                 1050             


Tyr Asp  Glu Asp Ser Lys Leu  Val Lys Gly Leu Ile  Asn Ile Asn 
    1055                 1060                 1065             


Asn Ser  Leu Phe Tyr Phe Asp  Pro Ile Glu Phe Asn  Leu Val Thr 
    1070                 1075                 1080             


Gly Trp  Gln Thr Ile Asn Gly  Lys Lys Tyr Tyr Phe  Asp Ile Asn 
    1085                 1090                 1095             


Thr Gly  Ala Ala Leu Ile Ser  Tyr Lys Ile Ile Asn  Gly Lys His 
    1100                 1105                 1110             


Phe Tyr  Phe Asn Asn Asp Gly  Val Met Gln Leu Gly  Val Phe Lys 
    1115                 1120                 1125             


Gly Pro  Asp Gly Phe Glu Tyr  Phe Ala Pro Ala Asn  Thr Gln Asn 
    1130                 1135                 1140             


Asn Asn  Ile Glu Gly Gln Ala  Ile Val Tyr Gln Ser  Lys Phe Leu 
    1145                 1150                 1155             


Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Asp Asn Asp  Ser Lys Ala 
    1160                 1165                 1170             


Val Thr  Gly Trp Arg Ile Ile  Asn Asn Glu Lys Tyr  Tyr Phe Asn 
    1175                 1180                 1185             


Pro Asn  Asn Ala Ile Ala Ala  Val Gly Leu Gln Val  Ile Asp Asn 
    1190                 1195                 1200             


Asn Lys  Tyr Tyr Phe Asn Pro  Asp Thr Ala Ile Ile  Ser Lys Gly 
    1205                 1210                 1215             


Trp Gln  Thr Val Asn Gly Ser  Arg Tyr Tyr Phe Asp  Thr Asp Thr 
    1220                 1225                 1230             


Ala Ile  Ala Phe Asn Gly Tyr  Lys Thr Ile Asp Gly  Lys His Phe 
    1235                 1240                 1245             


Tyr Phe  Asp Ser Asp Cys Val  Val Lys Ile Gly Val  Phe Ser Thr 
    1250                 1255                 1260             


Ser Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  Tyr Asn Asn 
    1265                 1270                 1275             


Asn Ile  Glu Gly Gln Ala Ile  Val Tyr Gln Ser Lys  Phe Leu Thr 
    1280                 1285                 1290             


Leu Asn  Gly Lys Lys Tyr Tyr  Phe Asp Asn Asn Ser  Lys Ala Val 
    1295                 1300                 1305             


Thr Gly  Trp Gln Thr Ile Asp  Ser Lys Lys Tyr Tyr  Phe Asn Thr 
    1310                 1315                 1320             


Asn Thr  Ala Glu Ala Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys 
    1325                 1330                 1335             


Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Glu Ala Ala  Thr Gly Trp 
    1340                 1345                 1350             


Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ala 
    1355                 1360                 1365             


Ile Ala  Ser Thr Gly Tyr Thr  Ile Ile Asn Gly Lys  His Phe Tyr 
    1370                 1375                 1380             


Phe Asn  Thr Asp Gly Ile Met  Gln Ile Gly Val Phe  Lys Gly Pro 
    1385                 1390                 1395             


Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn Thr Asp  Ala Asn Asn 
    1400                 1405                 1410             


Ile Glu  Gly Gln Ala Ile Leu  Tyr Gln Asn Glu Phe  Leu Thr Leu 
    1415                 1420                 1425             


Asn Gly  Lys Lys Tyr Tyr Phe  Gly Ser Asp Ser Lys  Ala Val Thr 
    1430                 1435                 1440             


Gly Trp  Arg Ile Ile Asn Asn  Lys Lys Tyr Tyr Phe  Asn Pro Asn 
    1445                 1450                 1455             


Asn Ala  Ile Ala Ala Ile His  Leu Cys Thr Ile Asn  Asn Asp Lys 
    1460                 1465                 1470             


Tyr Tyr  Phe Ser Tyr Asp Gly  Ile Leu Gln Asn Gly  Tyr Ile Thr 
    1475                 1480                 1485             


Ile Glu  Arg Asn Asn Phe Tyr  Phe Asp Ala Asn Asn  Glu Ser Lys 
    1490                 1495                 1500             


Met Val  Thr Gly Val Phe Lys  Gly Pro Asn Gly Phe  Glu Tyr Phe 
    1505                 1510                 1515             


Ala Pro  Ala Asn Thr His Asn  Asn Asn Ile Glu Gly  Gln Ala Ile 
    1520                 1525                 1530             


Val Tyr  Gln Asn Lys Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr 
    1535                 1540                 1545             


Phe Asp  Asn Asp Ser Lys Ala  Val Thr Gly Trp Gln  Thr Ile Asp 
    1550                 1555                 1560             


Gly Lys  Lys Tyr Tyr Phe Asn  Leu Asn Thr Ala Glu  Ala Ala Thr 
    1565                 1570                 1575             


Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr Tyr Phe  Asn Leu Asn 
    1580                 1585                 1590             


Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys 
    1595                 1600                 1605             


Tyr Tyr  Phe Asn Thr Asn Thr  Phe Ile Ala Ser Thr  Gly Tyr Thr 
    1610                 1615                 1620             


Ser Ile  Asn Gly Lys His Phe  Tyr Phe Asn Thr Asp  Gly Ile Met 
    1625                 1630                 1635             


Gln Ile  Gly Val Phe Lys Gly  Pro Asn Gly Phe Glu  Tyr Phe Ala 
    1640                 1645                 1650             


Pro Ala  Asn Thr His Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Leu 
    1655                 1660                 1665             


Tyr Gln  Asn Lys Phe Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe 
    1670                 1675                 1680             


Gly Ser  Asp Ser Lys Ala Val  Thr Gly Leu Arg Thr  Ile Asp Gly 
    1685                 1690                 1695             


Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ala Val Ala  Val Thr Gly 
    1700                 1705                 1710             


Trp Gln  Thr Ile Asn Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr 
    1715                 1720                 1725             


Ser Ile  Ala Ser Thr Gly Tyr  Thr Ile Ile Ser Gly  Lys His Phe 
    1730                 1735                 1740             


Tyr Phe  Asn Thr Asp Gly Ile  Met Gln Ile Gly Val  Phe Lys Gly 
    1745                 1750                 1755             


Pro Asp  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  Asp Ala Asn 
    1760                 1765                 1770             


Asn Ile  Glu Gly Gln Ala Ile  Arg Tyr Gln Asn Arg  Phe Leu Tyr 
    1775                 1780                 1785             


Leu His  Asp Asn Ile Tyr Tyr  Phe Gly Asn Asn Ser  Lys Ala Ala 
    1790                 1795                 1800             


Thr Gly  Trp Val Thr Ile Asp  Gly Asn Arg Tyr Tyr  Phe Glu Pro 
    1805                 1810                 1815             


Asn Thr  Ala Met Gly Ala Asn  Gly Tyr Lys Thr Ile  Asp Asn Lys 
    1820                 1825                 1830             


Asn Phe  Tyr Phe Arg Asn Gly  Leu Pro Gln Ile Gly  Val Phe Lys 
    1835                 1840                 1845             


Gly Ser  Asn Gly Phe Glu Tyr  Phe Ala Pro Ala Asn  Thr Asp Ala 
    1850                 1855                 1860             


Asn Asn  Ile Glu Gly Gln Ala  Ile Arg Tyr Gln Asn  Arg Phe Leu 
    1865                 1870                 1875             


His Leu  Leu Gly Lys Ile Tyr  Tyr Phe Gly Asn Asn  Ser Lys Ala 
    1880                 1885                 1890             


Val Thr  Gly Trp Gln Thr Ile  Asn Gly Lys Val Tyr  Tyr Phe Met 
    1895                 1900                 1905             


Pro Asp  Thr Ala Met Ala Ala  Ala Gly Gly Leu Phe  Glu Ile Asp 
    1910                 1915                 1920             


Gly Val  Ile Tyr Phe Phe Gly  Val Asp Gly Val Lys  Ala Pro Gly 
    1925                 1930                 1935             


Ile Tyr  Gly 
    1940     


<210>  8
<211>  1941
<212>  PRT
<213>  Clostridium difficile

<400>  8

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile 
1               5                   10                  15      


Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser 
            20                  25                  30          


Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro 
        35                  40                  45              


Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser 
    50                  55                  60                  


Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile 
65                  70                  75                  80  


Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu 
                85                  90                  95      


Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp 
            100                 105                 110         


Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr 
        115                 120                 125             


Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val 
    130                 135                 140                 


Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys 
145                 150                 155                 160 


Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn 
                165                 170                 175     


Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu 
            180                 185                 190         


Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys 
        195                 200                 205             


Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala 
    210                 215                 220                 


Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu 
225                 230                 235                 240 


Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu Pro 
                245                 250                 255     


Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp Gly Ile 
            260                 265                 270         


Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His Asp Pro Leu 
        275                 280                 285             


Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala Ile Asn Met 
    290                 295                 300                 


Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly Ile Gly Ala 
305                 310                 315                 320 


Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser Ala Gly Ile 
                325                 330                 335     


Pro Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys Ala Thr Ser 
            340                 345                 350         


Val Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Glu Tyr Gly Pro 
        355                 360                 365             


Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu Val 
    370                 375                 380                 


Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys 
385                 390                 395                 400 


Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn 
                405                 410                 415     


Ile Asp His Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser 
            420                 425                 430         


Leu Ser Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe 
        435                 440                 445             


Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp 
    450                 455                 460                 


Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly 
465                 470                 475                 480 


Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr 
                485                 490                 495     


Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys Pro 
            500                 505                 510         


Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp Lys Asp Thr Arg 
        515                 520                 525             


Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu Ile Arg Asn Lys Leu 
    530                 535                 540                 


Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu Ser 
545                 550                 555                 560 


Ser Tyr Pro Ile Ser Met Asn Ile Asn Leu Ser Lys Asp Asp Leu Trp 
                565                 570                 575     


Ile Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn Gly 
            580                 585                 590         


Thr Ile Lys Lys Gly Asn Leu Ile Glu Asp Val Leu Ser Lys Ile Asp 
        595                 600                 605             


Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser 
    610                 615                 620                 


Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu 
625                 630                 635                 640 


Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser 
                645                 650                 655     


Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu 
            660                 665                 670         


Ser Asn Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn 
        675                 680                 685             


Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala 
    690                 695                 700                 


Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser 
705                 710                 715                 720 


Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn Ser 
                725                 730                 735     


Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp Ile 
            740                 745                 750         


Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser 
        755                 760                 765             


Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val Asn 
    770                 775                 780                 


Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val 
785                 790                 795                 800 


Lys Asn Ser Asp Gly His His Asn Thr Ser Asn Phe Met Asn Leu Phe 
                805                 810                 815     


Leu Asn Asn Ile Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile Asn 
            820                 825                 830         


Phe Val Ile Asp Lys Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu Gly 
        835                 840                 845             


Tyr Val Glu Phe Ile Cys Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe 
    850                 855                 860                 


Gly Glu Trp Lys Thr Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn 
865                 870                 875                 880 


Gly Arg Asn Val Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu 
                885                 890                 895     


Asp Ile Ser Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile 
            900                 905                 910         


Asp Arg Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser 
        915                 920                 925             


Leu Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu 
    930                 935                 940                 


Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn 
945                 950                 955                 960 


Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser Asp 
                965                 970                 975     


Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu Gln 
            980                 985                 990         


Lys Ile Arg Ile Lys Gly Ile Leu  Ser Asn Thr Gln Ser  Phe Asn Lys 
        995                 1000                 1005             


Met Ser  Ile Asp Phe Lys Asp  Ile Lys Lys Leu Ser  Leu Gly Tyr 
    1010                 1015                 1020             


Ile Met  Ser Asn Phe Lys Ser  Phe Asn Ser Glu Asn  Glu Leu Asp 
    1025                 1030                 1035             


Arg Asp  His Leu Gly Phe Lys  Ile Ile Asp Asn Lys  Thr Tyr Tyr 
    1040                 1045                 1050             


Tyr Asp  Glu Asp Ser Lys Leu  Val Lys Gly Leu Ile  Asn Ile Asn 
    1055                 1060                 1065             


Asn Ser  Leu Phe Tyr Phe Asp  Pro Ile Glu Ser Asn  Leu Val Thr 
    1070                 1075                 1080             


Gly Trp  Gln Thr Ile Asn Gly  Lys Lys Tyr Tyr Phe  Asp Ile Asn 
    1085                 1090                 1095             


Thr Gly  Ala Ala Ser Thr Ser  Tyr Lys Ile Ile Asn  Gly Lys His 
    1100                 1105                 1110             


Phe Tyr  Phe Asn Asn Asn Gly  Val Met Gln Leu Gly  Val Phe Lys 
    1115                 1120                 1125             


Gly Pro  Asp Gly Phe Glu Tyr  Phe Ala Pro Ala Asn  Thr Gln Asn 
    1130                 1135                 1140             


Asn Asn  Ile Glu Gly Gln Ala  Ile Val Tyr Gln Ser  Lys Phe Leu 
    1145                 1150                 1155             


Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Asp Asn Asp  Ser Lys Ala 
    1160                 1165                 1170             


Val Thr  Gly Trp Arg Ile Ile  Asn Asn Glu Lys Tyr  Tyr Phe Asn 
    1175                 1180                 1185             


Pro Asn  Asn Ala Ile Ala Ala  Val Gly Leu Gln Val  Ile Asp Asn 
    1190                 1195                 1200             


Asn Lys  Tyr Tyr Phe Asn Pro  Asp Thr Ala Ile Ile  Ser Lys Gly 
    1205                 1210                 1215             


Trp Gln  Thr Val Asn Gly Ser  Arg Tyr Tyr Phe Asp  Thr Asp Thr 
    1220                 1225                 1230             


Ala Ile  Ala Phe Asn Gly Tyr  Lys Thr Ile Asp Gly  Lys His Phe 
    1235                 1240                 1245             


Tyr Phe  Asp Ser Asp Cys Val  Val Lys Ile Gly Val  Phe Ser Gly 
    1250                 1255                 1260             


Ser Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  Tyr Asn Asn 
    1265                 1270                 1275             


Asn Ile  Glu Gly Gln Ala Ile  Val Tyr Gln Ser Lys  Phe Leu Thr 
    1280                 1285                 1290             


Leu Asn  Gly Lys Lys Tyr Tyr  Phe Asp Asn Asn Ser  Lys Ala Val 
    1295                 1300                 1305             


Thr Gly  Trp Gln Thr Ile Asp  Ser Lys Lys Tyr Tyr  Phe Asn Thr 
    1310                 1315                 1320             


Asn Thr  Ala Glu Ala Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys 
    1325                 1330                 1335             


Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Glu Ala Ala  Thr Gly Trp 
    1340                 1345                 1350             


Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ser 
    1355                 1360                 1365             


Ile Ala  Ser Thr Gly Tyr Thr  Ile Ile Asn Gly Lys  Tyr Phe Tyr 
    1370                 1375                 1380             


Phe Asn  Thr Asp Gly Ile Met  Gln Ile Gly Val Phe  Lys Val Pro 
    1385                 1390                 1395             


Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn Thr His  Asn Asn Asn 
    1400                 1405                 1410             


Ile Glu  Gly Gln Ala Ile Leu  Tyr Gln Asn Lys Phe  Leu Thr Leu 
    1415                 1420                 1425             


Asn Gly  Lys Lys Tyr Tyr Phe  Gly Ser Asp Ser Lys  Ala Ile Thr 
    1430                 1435                 1440             


Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr Tyr Phe  Asn Pro Asn 
    1445                 1450                 1455             


Asn Ala  Ile Ala Ala Thr His  Leu Cys Thr Ile Asn  Asn Asp Lys 
    1460                 1465                 1470             


Tyr Tyr  Phe Ser Tyr Asp Gly  Ile Leu Gln Asn Gly  Tyr Ile Thr 
    1475                 1480                 1485             


Ile Glu  Arg Asn Asn Phe Tyr  Phe Asp Ala Asn Asn  Glu Ser Lys 
    1490                 1495                 1500             


Met Val  Thr Gly Val Phe Lys  Gly Pro Asn Gly Phe  Glu Tyr Phe 
    1505                 1510                 1515             


Ala Pro  Ala Asn Thr His Asn  Asn Asn Ile Glu Gly  Gln Ala Ile 
    1520                 1525                 1530             


Val Tyr  Gln Asn Lys Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr 
    1535                 1540                 1545             


Phe Asp  Asn Asp Ser Lys Ala  Val Thr Gly Trp Gln  Thr Ile Asp 
    1550                 1555                 1560             


Ser Lys  Lys Tyr Tyr Phe Asn  Leu Asn Thr Ala Val  Ala Val Thr 
    1565                 1570                 1575             


Gly Trp  Gln Thr Ile Asp Gly  Glu Lys Tyr Tyr Phe  Asn Leu Asn 
    1580                 1585                 1590             


Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Arg 
    1595                 1600                 1605             


Tyr Tyr  Phe Asn Thr Asn Thr  Tyr Ile Ala Ser Thr  Gly Tyr Thr 
    1610                 1615                 1620             


Ile Ile  Asn Gly Lys His Phe  Tyr Phe Asn Thr Asp  Gly Ile Met 
    1625                 1630                 1635             


Gln Ile  Gly Val Phe Lys Gly  Pro Asp Gly Phe Glu  Tyr Phe Ala 
    1640                 1645                 1650             


Pro Ala  Asn Thr His Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Leu 
    1655                 1660                 1665             


Tyr Gln  Asn Lys Phe Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe 
    1670                 1675                 1680             


Gly Ser  Asp Ser Lys Ala Val  Thr Gly Leu Arg Thr  Ile Asp Gly 
    1685                 1690                 1695             


Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ala Val Ala  Val Thr Gly 
    1700                 1705                 1710             


Trp Gln  Thr Ile Asn Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr 
    1715                 1720                 1725             


Tyr Ile  Ala Ser Thr Gly Tyr  Thr Ile Ile Ser Gly  Lys His Phe 
    1730                 1735                 1740             


Tyr Phe  Asn Thr Asp Gly Ile  Met Gln Ile Gly Val  Phe Lys Gly 
    1745                 1750                 1755             


Pro Asp  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  Asp Ala Asn 
    1760                 1765                 1770             


Asn Ile  Glu Gly Gln Ala Ile  Arg Tyr Gln Asn Arg  Phe Leu Tyr 
    1775                 1780                 1785             


Leu His  Asp Asn Ile Tyr Tyr  Phe Gly Asn Asp Ser  Lys Ala Ala 
    1790                 1795                 1800             


Thr Gly  Trp Ala Thr Ile Asp  Gly Asn Arg Tyr Tyr  Phe Glu Pro 
    1805                 1810                 1815             


Asn Thr  Ala Met Gly Ala Asn  Gly Tyr Lys Thr Ile  Asp Asn Lys 
    1820                 1825                 1830             


Asn Phe  Tyr Phe Arg Asn Gly  Leu Pro Gln Ile Gly  Val Phe Lys 
    1835                 1840                 1845             


Gly Pro  Asn Gly Phe Glu Tyr  Phe Ala Pro Ala Asn  Thr Asp Ala 
    1850                 1855                 1860             


Asn Asn  Ile Asp Gly Gln Ala  Ile Arg Tyr Gln Asn  Arg Phe Leu 
    1865                 1870                 1875             


His Leu  Leu Gly Lys Ile Tyr  Tyr Phe Gly Asn Asn  Ser Lys Ala 
    1880                 1885                 1890             


Val Thr  Gly Trp Gln Thr Ile  Asn Ser Lys Val Tyr  Tyr Phe Met 
    1895                 1900                 1905             


Pro Asp  Thr Ala Met Ala Ala  Ala Gly Gly Leu Phe  Glu Ile Asp 
    1910                 1915                 1920             


Gly Val  Ile Tyr Phe Phe Gly  Val Asp Gly Val Lys  Ala Pro Gly 
    1925                 1930                 1935             


Ile Tyr  Gly 
    1940     


<210>  9
<211>  1222
<212>  PRT
<213>  Clostridium difficile

<400>  9

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn 
1               5                   10                  15      


Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly Gly Ser 
            20                  25                  30          


Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser Ala Pro Ser 
        35                  40                  45              


Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp Val Leu Glu Val 
    50                  55                  60                  


Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu Met Val Leu Pro Asn 
65                  70                  75                  80  


Ala Pro Asn Arg Val Phe Ala Trp Glu Thr Gly Trp Thr Pro Gly Leu 
                85                  90                  95      


Arg Ser Leu Glu Asn Asp Gly Thr Lys Leu Leu Asp Arg Ile Arg Asp 
            100                 105                 110         


Asn Tyr Glu Gly Glu Phe Tyr Trp Arg Tyr Phe Ala Phe Ile Ala Asp 
        115                 120                 125             


Ala Leu Ile Thr Thr Leu Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg 
    130                 135                 140                 


Ile Asn Leu Asp Ser Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr 
145                 150                 155                 160 


Thr Glu Tyr Ile Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly 
                165                 170                 175     


Gly Thr Tyr Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile 
            180                 185                 190         


Glu Leu Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val 
        195                 200                 205             


Arg Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile 
    210                 215                 220                 


Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu 
225                 230                 235                 240 


Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn Gly 
                245                 250                 255     


Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala Ile Ile 
            260                 265                 270         


Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile Ser Gly Glu 
        275                 280                 285             


Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln Gln Lys Ile Asp 
    290                 295                 300                 


Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn Ile Pro Tyr Ser Phe 
305                 310                 315                 320 


Val Asp Ser Glu Gly Lys Glu Asn Gly Phe Ile Asn Gly Ser Thr Lys 
                325                 330                 335     


Glu Gly Leu Phe Val Ser Glu Leu Pro Asp Val Val Leu Ile Ser Lys 
            340                 345                 350         


Val Tyr Met Asp Asp Ser Lys Pro Ser Phe Gly Tyr Tyr Ser Asn Asn 
        355                 360                 365             


Leu Lys Asp Val Lys Val Ile Thr Lys Asp Asn Val Asn Ile Leu Thr 
    370                 375                 380                 


Gly Tyr Tyr Leu Lys Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu 
385                 390                 395                 400 


Gln Asp Glu Lys Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser 
                405                 410                 415     


Gly Val Ala Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn 
            420                 425                 430         


Thr Ser Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser 
        435                 440                 445             


Ile Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala 
    450                 455                 460                 


Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile 
465                 470                 475                 480 


Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn Thr 
                485                 490                 495     


Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn Met Ile 
            500                 505                 510         


Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile Ser Ser Thr 
        515                 520                 525             


Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile Asp Ser Cys Val 
    530                 535                 540                 


Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr Asp Glu Ile Asn Ile 
545                 550                 555                 560 


Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr Pro Glu Val Ile Val Leu 
                565                 570                 575     


Asp Ala Asn Tyr Ile Asn Glu Lys Ile Asn Val Asn Ile Asn Asp Leu 
            580                 585                 590         


Ser Ile Arg Tyr Val Trp Ser Asn Asp Gly Asn Asp Phe Ile Leu Met 
        595                 600                 605             


Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys Ile Arg Phe Val 
    610                 615                 620                 


Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe 
625                 630                 635                 640 


Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr 
                645                 650                 655     


Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val 
            660                 665                 670         


Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val 
        675                 680                 685             


Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro 
    690                 695                 700                 


Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr 
705                 710                 715                 720 


Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr Ile 
                725                 730                 735     


Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu Gln Thr 
            740                 745                 750         


Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asn 
        755                 760                 765             


Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys 
    770                 775                 780                 


Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr Arg Gly 
785                 790                 795                 800 


Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His Tyr Phe Ser Pro 
                805                 810                 815     


Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp Tyr Lys 
            820                 825                 830         


Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly Phe Val Ser Ile 
        835                 840                 845             


Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val Met Lys Val Gly 
    850                 855                 860                 


Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu 
865                 870                 875                 880 


Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala 
                885                 890                 895     


His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr 
            900                 905                 910         


Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser 
        915                 920                 925             


Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr 
    930                 935                 940                 


Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile 
945                 950                 955                 960 


Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val Gly 
                965                 970                 975     


Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly Ile 
            980                 985                 990         


Ile Glu Ser Gly Val Gln Asn Ile  Asp Asp Asn Tyr Phe  Tyr Ile Asp 
        995                 1000                 1005             


Asp Asn  Gly Ile Val Gln Ile  Gly Val Phe Asp Thr  Ser Asp Gly 
    1010                 1015                 1020             


Tyr Lys  Tyr Phe Ala Pro Ala  Asn Thr Val Asn Asp  Asn Ile Tyr 
    1025                 1030                 1035             


Gly Gln  Ala Val Glu Tyr Ser  Gly Leu Val Arg Val  Gly Glu Asp 
    1040                 1045                 1050             


Val Tyr  Tyr Phe Gly Glu Thr  Tyr Thr Ile Glu Thr  Gly Trp Ile 
    1055                 1060                 1065             


Tyr Asp  Met Glu Asn Glu Ser  Asp Lys Tyr Tyr Phe  Asn Pro Glu 
    1070                 1075                 1080             


Thr Lys  Lys Ala Cys Lys Gly  Ile Asn Leu Ile Asp  Asp Ile Lys 
    1085                 1090                 1095             


Tyr Tyr  Phe Asp Glu Lys Gly  Ile Met Arg Thr Gly  Leu Ile Ser 
    1100                 1105                 1110             


Phe Glu  Asn Asn Asn Tyr Tyr  Phe Asn Glu Asn Gly  Glu Met Gln 
    1115                 1120                 1125             


Phe Gly  Tyr Ile Asn Ile Glu  Asp Lys Met Phe Tyr  Phe Gly Glu 
    1130                 1135                 1140             


Asp Gly  Val Met Gln Ile Gly  Val Phe Asn Thr Pro  Asp Gly Phe 
    1145                 1150                 1155             


Lys Tyr  Phe Ala His Gln Asn  Thr Leu Asp Glu Asn  Phe Glu Gly 
    1160                 1165                 1170             


Glu Ser  Ile Asn Tyr Thr Gly  Trp Leu Asp Leu Asp  Glu Lys Arg 
    1175                 1180                 1185             


Tyr Tyr  Phe Thr Asp Glu Tyr  Ile Ala Ala Thr Gly  Ser Val Ile 
    1190                 1195                 1200             


Ile Asp  Gly Glu Glu Tyr Tyr  Phe Asp Pro Asp Thr  Ala Gln Leu 
    1205                 1210                 1215             


Val Ile  Ser Glu 
    1220         


<210>  10
<211>  1222
<212>  PRT
<213>  Clostridium difficile

<400>  10

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn 
1               5                   10                  15      


Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly Gly Ser 
            20                  25                  30          


Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser Ala Pro Ser 
        35                  40                  45              


Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp Val Leu Glu Val 
    50                  55                  60                  


Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu Met Val Leu Pro Asn 
65                  70                  75                  80  


Ala Pro Asn Arg Val Phe Ala Trp Glu Thr Gly Trp Thr Pro Gly Leu 
                85                  90                  95      


Arg Ser Leu Glu Asn Asp Gly Thr Lys Leu Leu Asp Arg Ile Arg Asp 
            100                 105                 110         


Asn Tyr Glu Gly Glu Phe Tyr Trp Arg Tyr Phe Ala Phe Ile Ala Asp 
        115                 120                 125             


Ala Leu Ile Thr Thr Leu Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg 
    130                 135                 140                 


Ile Asn Leu Asp Ser Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr 
145                 150                 155                 160 


Thr Glu Tyr Ile Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly 
                165                 170                 175     


Gly Thr Tyr Ala Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile 
            180                 185                 190         


Glu Leu Asn Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val 
        195                 200                 205             


Arg Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile 
    210                 215                 220                 


Glu Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu 
225                 230                 235                 240 


Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly Asn Gly 
                245                 250                 255     


Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala Val Ile 
            260                 265                 270         


Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu Ile Ser Gly Glu 
        275                 280                 285             


Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val Gln Gln Lys Ile Asp 
    290                 295                 300                 


Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys Asn Ile Pro Tyr Ser Phe 
305                 310                 315                 320 


Met Asp Asp Lys Gly Lys Glu Asn Gly Phe Ile Asn Cys Ser Thr Lys 
                325                 330                 335     


Glu Gly Leu Phe Val Ser Glu Leu Ser Asp Val Val Leu Ile Ser Lys 
            340                 345                 350         


Val Tyr Met Asp Asn Ser Lys Pro Leu Phe Gly Tyr Cys Ser Asn Asp 
        355                 360                 365             


Leu Lys Asp Val Lys Val Ile Thr Lys Asp Asp Val Ile Ile Leu Thr 
    370                 375                 380                 


Gly Tyr Tyr Leu Lys Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile 
385                 390                 395                 400 


Gln Asp Glu Asn Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn 
                405                 410                 415     


Gly Val Ala Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn 
            420                 425                 430         


Thr Ser Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser 
        435                 440                 445             


Ile Phe Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr 
    450                 455                 460                 


Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile 
465                 470                 475                 480 


Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn Thr 
                485                 490                 495     


Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn Met Ile 
            500                 505                 510         


Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile Ser Ser Thr 
        515                 520                 525             


Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile Asp Ser Cys Val 
    530                 535                 540                 


Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr Thr Asp Glu Ile Asn Ile 
545                 550                 555                 560 


Thr Pro Ile Tyr Glu Ala Asn Asn Thr Tyr Pro Glu Val Ile Val Leu 
                565                 570                 575     


Asp Thr Asn Tyr Ile Ser Glu Lys Ile Asn Ile Asn Ile Asn Asp Leu 
            580                 585                 590         


Ser Ile Arg Tyr Val Trp Ser Asn Asp Gly Ser Asp Phe Ile Leu Met 
        595                 600                 605             


Ser Thr Asp Glu Glu Asn Lys Val Ser Gln Val Lys Ile Arg Phe Thr 
    610                 615                 620                 


Asn Val Phe Lys Gly Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe 
625                 630                 635                 640 


Ser Asp Lys Gln Asp Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr 
                645                 650                 655     


Pro Ser Tyr Tyr Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile 
            660                 665                 670         


Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val 
        675                 680                 685             


Ser Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro 
    690                 695                 700                 


Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys Tyr 
705                 710                 715                 720 


Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu Thr Ile 
                725                 730                 735     


Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val Leu Gln Thr 
            740                 745                 750         


Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asp 
        755                 760                 765             


Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys 
    770                 775                 780                 


Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly Asp Asn Tyr Arg Ala 
785                 790                 795                 800 


Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu Val Tyr Tyr Phe Ser Thr 
                805                 810                 815     


Asp Thr Gly Arg Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp Asp Lys 
            820                 825                 830         


Phe Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly Phe Val Asn Ile 
        835                 840                 845             


Asn Asp Lys Thr Phe Tyr Phe Asp Asp Ser Gly Val Met Lys Ser Gly 
    850                 855                 860                 


Tyr Thr Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu 
865                 870                 875                 880 


Met Gln Ile Gly Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala 
                885                 890                 895     


His His Asp Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr 
            900                 905                 910         


Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser 
        915                 920                 925             


Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr 
    930                 935                 940                 


Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile Ile 
945                 950                 955                 960 


Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln Ile Gly 
                965                 970                 975     


Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp Ser Gly Ile 
            980                 985                 990         


Val Glu Ser Gly Met Gln Asn Ile  Asp Asp Asn Tyr Phe  Tyr Ile Asp 
        995                 1000                 1005             


Glu Asn  Gly Leu Val Gln Ile  Gly Val Phe Asp Thr  Ser Asp Gly 
    1010                 1015                 1020             


Tyr Lys  Tyr Phe Ala Pro Ala  Asn Thr Val Asn Asp  Asn Ile Tyr 
    1025                 1030                 1035             


Gly Gln  Ala Val Glu Tyr Ser  Gly Leu Val Arg Val  Gly Glu Asp 
    1040                 1045                 1050             


Val Tyr  Tyr Phe Gly Glu Thr  Tyr Thr Ile Glu Thr  Gly Trp Ile 
    1055                 1060                 1065             


Tyr Asp  Met Glu Asn Glu Ser  Asp Lys Tyr Tyr Phe  Asp Pro Glu 
    1070                 1075                 1080             


Thr Lys  Lys Ala Tyr Lys Gly  Ile Asn Val Ile Asp  Asp Ile Lys 
    1085                 1090                 1095             


Tyr Tyr  Phe Asp Glu Asn Gly  Ile Met Arg Thr Gly  Leu Ile Thr 
    1100                 1105                 1110             


Phe Glu  Asp Asn His Tyr Tyr  Phe Asn Glu Asp Gly  Ile Met Gln 
    1115                 1120                 1125             


Tyr Gly  Tyr Leu Asn Ile Glu  Asp Lys Thr Phe Tyr  Phe Ser Glu 
    1130                 1135                 1140             


Asp Gly  Ile Met Gln Ile Gly  Val Phe Asn Thr Pro  Asp Gly Phe 
    1145                 1150                 1155             


Lys Tyr  Phe Ala His Gln Asn  Thr Leu Asp Glu Asn  Phe Glu Gly 
    1160                 1165                 1170             


Glu Ser  Ile Asn Tyr Thr Gly  Trp Leu Asp Leu Asp  Glu Lys Arg 
    1175                 1180                 1185             


Tyr Tyr  Phe Thr Asp Glu Tyr  Ile Ala Ala Thr Gly  Ser Val Ile 
    1190                 1195                 1200             


Ile Asp  Gly Glu Glu Tyr Tyr  Phe Asp Pro Asp Thr  Ala Gln Leu 
    1205                 1210                 1215             


Val Ile  Ser Glu 
    1220         


<210>  11
<211>  1410
<212>  PRT
<213>  Clostridium difficile

<400>  11

Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn 
1               5                   10                  15      


Ser Ser Lys Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln 
            20                  25                  30          


Val Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala 
        35                  40                  45              


Ala Lys Val Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp 
    50                  55                  60                  


Leu Leu Pro Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile 
65                  70                  75                  80  


Asp Gly Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser 
                85                  90                  95      


Asp Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala 
            100                 105                 110         


Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly 
        115                 120                 125             


Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile Ser 
    130                 135                 140                 


Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg Asp Lys 
145                 150                 155                 160 


Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu Val Glu Thr 
                165                 170                 175     


Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met Met Pro Gln Asp 
            180                 185                 190         


Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Val Leu 
        195                 200                 205             


Gly Lys Cys Glu Ile Trp Arg Met Glu Gly Gly Ser Gly His Thr Val 
    210                 215                 220                 


Thr Asp Asp Ile Asp His Phe Phe Ser Ala Pro Ser Ile Thr Tyr Arg 
225                 230                 235                 240 


Glu Pro His Leu Ser Ile Tyr Asp Val Leu Glu Val Gln Lys Glu Glu 
                245                 250                 255     


Leu Asp Leu Ser Lys Asp Leu Met Val Leu Pro Asn Ala Pro Asn Arg 
            260                 265                 270         


Val Phe Ala Trp Glu Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu 
        275                 280                 285             


Asn Asp Gly Thr Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly 
    290                 295                 300                 


Glu Phe Tyr Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr 
305                 310                 315                 320 


Thr Leu Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp 
                325                 330                 335     


Ser Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile 
            340                 345                 350         


Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala 
        355                 360                 365             


Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser Glu 
    370                 375                 380                 


Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp Val Thr 
385                 390                 395                 400 


Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu Gly Ile Leu 
                405                 410                 415     


Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu Asn Ser His Glu 
            420                 425                 430         


Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn Gly Phe Val Ser Leu 
        435                 440                 445             


Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala Ile Ile Glu Val Asp Leu 
    450                 455                 460                 


Leu Ser Lys Ser Tyr Lys Leu Leu Ile Ser Gly Glu Leu Lys Ile Leu 
465                 470                 475                 480 


Met Leu Asn Ser Asn His Ile Gln Gln Lys Ile Asp Tyr Ile Gly Phe 
                485                 490                 495     


Asn Ser Glu Leu Gln Lys Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu 
            500                 505                 510         


Gly Lys Glu Asn Gly Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe 
        515                 520                 525             


Val Ser Glu Leu Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp 
    530                 535                 540                 


Asp Ser Lys Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val 
545                 550                 555                 560 


Lys Val Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu 
                565                 570                 575     


Lys Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys 
            580                 585                 590         


Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu 
        595                 600                 605             


Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp Ser 
    610                 615                 620                 


Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe Val Asn 
625                 630                 635                 640 


Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn Phe Ile Ile 
                645                 650                 655     


Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile Cys Asp Glu Asn 
            660                 665                 670         


Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn Thr Leu Glu Thr Asn 
        675                 680                 685             


Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn Met Ile Val Glu Pro Asn 
    690                 695                 700                 


Tyr Asp Leu Asp Asp Ser Gly Asp Ile Ser Ser Thr Val Ile Asn Phe 
705                 710                 715                 720 


Ser Gln Lys Tyr Leu Tyr Gly Ile Asp Ser Cys Val Asn Lys Val Val 
                725                 730                 735     


Ile Ser Pro Asn Ile Tyr Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr 
            740                 745                 750         


Glu Thr Asn Asn Thr Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr 
        755                 760                 765             


Ile Asn Glu Lys Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr 
    770                 775                 780                 


Val Trp Ser Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu 
785                 790                 795                 800 


Glu Asn Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys 
                805                 810                 815     


Asp Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln 
            820                 825                 830         


Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr 
        835                 840                 845             


Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr Asn 
    850                 855                 860                 


Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly Leu Ile 
865                 870                 875                 880 


Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val Asn Asn Leu 
                885                 890                 895     


Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr Tyr Phe Asn Pro 
            900                 905                 910         


Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr Ile Ile Asp Asp Lys 
        915                 920                 925             


Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu Gln Thr Gly Val Phe Ser 
    930                 935                 940                 


Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asn Thr Leu Asp Glu 
945                 950                 955                 960 


Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys Leu Ile Ile Asp 
                965                 970                 975     


Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp 
            980                 985                 990         


Lys Glu Leu Asp Gly Glu Met His  Tyr Phe Ser Pro Glu  Thr Gly Lys 
        995                 1000                 1005             


Ala Phe  Lys Gly Leu Asn Gln  Ile Gly Asp Tyr Lys  Tyr Tyr Phe 
    1010                 1015                 1020             


Asn Ser  Asp Gly Val Met Gln  Lys Gly Phe Val Ser  Ile Asn Asp 
    1025                 1030                 1035             


Asn Lys  His Tyr Phe Asp Asp  Ser Gly Val Met Lys  Val Gly Tyr 
    1040                 1045                 1050             


Thr Glu  Ile Asp Gly Lys His  Phe Tyr Phe Ala Glu  Asn Gly Glu 
    1055                 1060                 1065             


Met Gln  Ile Gly Val Phe Asn  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1070                 1075                 1080             


Ala His  His Asn Glu Asp Leu  Gly Asn Glu Glu Gly  Glu Glu Ile 
    1085                 1090                 1095             


Ser Tyr  Ser Gly Ile Leu Asn  Phe Asn Asn Lys Ile  Tyr Tyr Phe 
    1100                 1105                 1110             


Asp Asp  Ser Phe Thr Ala Val  Val Gly Trp Lys Asp  Leu Glu Asp 
    1115                 1120                 1125             


Gly Ser  Lys Tyr Tyr Phe Asp  Glu Asp Thr Ala Glu  Ala Tyr Ile 
    1130                 1135                 1140             


Gly Leu  Ser Leu Ile Asn Asp  Gly Gln Tyr Tyr Phe  Asn Asp Asp 
    1145                 1150                 1155             


Gly Ile  Met Gln Val Gly Phe  Val Thr Ile Asn Asp  Lys Val Phe 
    1160                 1165                 1170             


Tyr Phe  Ser Asp Ser Gly Ile  Ile Glu Ser Gly Val  Gln Asn Ile 
    1175                 1180                 1185             


Asp Asp  Asn Tyr Phe Tyr Ile  Asp Asp Asn Gly Ile  Val Gln Ile 
    1190                 1195                 1200             


Gly Val  Phe Asp Thr Ser Asp  Gly Tyr Lys Tyr Phe  Ala Pro Ala 
    1205                 1210                 1215             


Asn Thr  Val Asn Asp Asn Ile  Tyr Gly Gln Ala Val  Glu Tyr Ser 
    1220                 1225                 1230             


Gly Leu  Val Arg Val Gly Glu  Asp Val Tyr Tyr Phe  Gly Glu Thr 
    1235                 1240                 1245             


Tyr Thr  Ile Glu Thr Gly Trp  Ile Tyr Asp Met Glu  Asn Glu Ser 
    1250                 1255                 1260             


Asp Lys  Tyr Tyr Phe Asn Pro  Glu Thr Lys Lys Ala  Cys Lys Gly 
    1265                 1270                 1275             


Ile Asn  Leu Ile Asp Asp Ile  Lys Tyr Tyr Phe Asp  Glu Lys Gly 
    1280                 1285                 1290             


Ile Met  Arg Thr Gly Leu Ile  Ser Phe Glu Asn Asn  Asn Tyr Tyr 
    1295                 1300                 1305             


Phe Asn  Glu Asn Gly Glu Met  Gln Phe Gly Tyr Ile  Asn Ile Glu 
    1310                 1315                 1320             


Asp Lys  Met Phe Tyr Phe Gly  Glu Asp Gly Val Met  Gln Ile Gly 
    1325                 1330                 1335             


Val Phe  Asn Thr Pro Asp Gly  Phe Lys Tyr Phe Ala  His Gln Asn 
    1340                 1345                 1350             


Thr Leu  Asp Glu Asn Phe Glu  Gly Glu Ser Ile Asn  Tyr Thr Gly 
    1355                 1360                 1365             


Trp Leu  Asp Leu Asp Glu Lys  Arg Tyr Tyr Phe Thr  Asp Glu Tyr 
    1370                 1375                 1380             


Ile Ala  Ala Thr Gly Ser Val  Ile Ile Asp Gly Glu  Glu Tyr Tyr 
    1385                 1390                 1395             


Phe Asp  Pro Asp Thr Ala Gln  Leu Val Ile Ser Glu  
    1400                 1405                 1410 


<210>  12
<211>  1410
<212>  PRT
<213>  Clostridium difficile

<400>  12

Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn 
1               5                   10                  15      


Ser Ser Lys Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln 
            20                  25                  30          


Val Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala 
        35                  40                  45              


Ala Lys Val Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp 
    50                  55                  60                  


Leu Leu Pro Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile 
65                  70                  75                  80  


Asp Gly Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser 
                85                  90                  95      


Asp Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala 
            100                 105                 110         


Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly 
        115                 120                 125             


Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile Ser 
    130                 135                 140                 


Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu Arg Asp Lys 
145                 150                 155                 160 


Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser Leu Ala Glu Ser 
                165                 170                 175     


Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile Met Met Pro Gln Asp 
            180                 185                 190         


Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Thr Leu 
        195                 200                 205             


Gly Lys Cys Glu Ile Trp Arg Met Glu Gly Gly Ser Gly His Thr Val 
    210                 215                 220                 


Thr Asp Asp Ile Asp His Phe Phe Ser Ala Pro Ser Ile Thr Tyr Arg 
225                 230                 235                 240 


Glu Pro His Leu Ser Ile Tyr Asp Val Leu Glu Val Gln Lys Glu Glu 
                245                 250                 255     


Leu Asp Leu Ser Lys Asp Leu Met Val Leu Pro Asn Ala Pro Asn Arg 
            260                 265                 270         


Val Phe Ala Trp Glu Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu 
        275                 280                 285             


Asn Asp Gly Thr Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly 
    290                 295                 300                 


Glu Phe Tyr Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr 
305                 310                 315                 320 


Thr Leu Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp 
                325                 330                 335     


Ser Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile 
            340                 345                 350         


Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala 
        355                 360                 365             


Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu Asn Glu 
    370                 375                 380                 


Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg Asp Val Thr 
385                 390                 395                 400 


Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu Asn Ile Leu 
                405                 410                 415     


Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu Asp Asn His Glu 
            420                 425                 430         


Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly Asn Gly Phe Val Ser Leu 
        435                 440                 445             


Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala Val Ile Glu Val Asp Leu 
    450                 455                 460                 


Leu Ser Lys Ser Tyr Lys Val Leu Ile Ser Gly Glu Leu Lys Thr Leu 
465                 470                 475                 480 


Met Ala Asn Ser Asn Ser Val Gln Gln Lys Ile Asp Tyr Ile Gly Leu 
                485                 490                 495     


Asn Ser Glu Leu Gln Lys Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys 
            500                 505                 510         


Gly Lys Glu Asn Gly Phe Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe 
        515                 520                 525             


Val Ser Glu Leu Ser Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp 
    530                 535                 540                 


Asn Ser Lys Pro Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val 
545                 550                 555                 560 


Lys Val Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu 
                565                 570                 575     


Lys Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn 
            580                 585                 590         


Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala Glu 
        595                 600                 605             


Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp Ser 
    610                 615                 620                 


Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe Ile Asn 
625                 630                 635                 640 


Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr Asn Phe Ile Ile 
                645                 650                 655     


Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile Cys Asp Lys Asp 
            660                 665                 670         


Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn Thr Leu Glu Thr Lys 
        675                 680                 685             


Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn Met Ile Val Glu Pro Asn 
    690                 695                 700                 


Tyr Asp Leu Asp Asp Ser Gly Asp Ile Ser Ser Thr Val Ile Asn Phe 
705                 710                 715                 720 


Ser Gln Lys Tyr Leu Tyr Gly Ile Asp Ser Cys Val Asn Lys Val Ile 
                725                 730                 735     


Ile Ser Pro Asn Ile Tyr Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr 
            740                 745                 750         


Glu Ala Asn Asn Thr Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr 
        755                 760                 765             


Ile Ser Glu Lys Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr 
    770                 775                 780                 


Val Trp Ser Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu 
785                 790                 795                 800 


Glu Asn Lys Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys 
                805                 810                 815     


Gly Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln 
            820                 825                 830         


Asp Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr Tyr 
        835                 840                 845             


Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu Tyr Asn 
    850                 855                 860                 


Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly Leu Val 
865                 870                 875                 880 


Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Ile Lys Asn Leu 
                885                 890                 895     


Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Pro 
            900                 905                 910         


Asp Asn Gly Gly Ala Ala Ser Val Gly Glu Thr Ile Ile Asp Gly Lys 
        915                 920                 925             


Asn Tyr Tyr Phe Ser Gln Asn Gly Val Leu Gln Thr Gly Val Phe Ser 
    930                 935                 940                 


Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asp Thr Leu Asp Glu 
945                 950                 955                 960 


Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys Leu Thr Ile Asp 
                965                 970                 975     


Glu Asn Val Tyr Tyr Phe Gly Asp Asn Tyr Arg Ala Ala Ile Glu Trp 
            980                 985                 990         


Gln Thr Leu Asp Asp Glu Val Tyr  Tyr Phe Ser Thr Asp  Thr Gly Arg 
        995                 1000                 1005             


Ala Phe  Lys Gly Leu Asn Gln  Ile Gly Asp Asp Lys  Phe Tyr Phe 
    1010                 1015                 1020             


Asn Ser  Asp Gly Ile Met Gln  Lys Gly Phe Val Asn  Ile Asn Asp 
    1025                 1030                 1035             


Lys Thr  Phe Tyr Phe Asp Asp  Ser Gly Val Met Lys  Ser Gly Tyr 
    1040                 1045                 1050             


Thr Glu  Ile Asp Gly Lys Tyr  Phe Tyr Phe Ala Glu  Asn Gly Glu 
    1055                 1060                 1065             


Met Gln  Ile Gly Val Phe Asn  Thr Ala Asp Gly Phe  Lys Tyr Phe 
    1070                 1075                 1080             


Ala His  His Asp Glu Asp Leu  Gly Asn Glu Glu Gly  Glu Ala Leu 
    1085                 1090                 1095             


Ser Tyr  Ser Gly Ile Leu Asn  Phe Asn Asn Lys Ile  Tyr Tyr Phe 
    1100                 1105                 1110             


Asp Asp  Ser Phe Thr Ala Val  Val Gly Trp Lys Asp  Leu Glu Asp 
    1115                 1120                 1125             


Gly Ser  Lys Tyr Tyr Phe Asp  Glu Asp Thr Ala Glu  Ala Tyr Ile 
    1130                 1135                 1140             


Gly Ile  Ser Ile Ile Asn Asp  Gly Lys Tyr Tyr Phe  Asn Asp Ser 
    1145                 1150                 1155             


Gly Ile  Met Gln Ile Gly Phe  Val Thr Ile Asn Asn  Glu Val Phe 
    1160                 1165                 1170             


Tyr Phe  Ser Asp Ser Gly Ile  Val Glu Ser Gly Met  Gln Asn Ile 
    1175                 1180                 1185             


Asp Asp  Asn Tyr Phe Tyr Ile  Asp Glu Asn Gly Leu  Val Gln Ile 
    1190                 1195                 1200             


Gly Val  Phe Asp Thr Ser Asp  Gly Tyr Lys Tyr Phe  Ala Pro Ala 
    1205                 1210                 1215             


Asn Thr  Val Asn Asp Asn Ile  Tyr Gly Gln Ala Val  Glu Tyr Ser 
    1220                 1225                 1230             


Gly Leu  Val Arg Val Gly Glu  Asp Val Tyr Tyr Phe  Gly Glu Thr 
    1235                 1240                 1245             


Tyr Thr  Ile Glu Thr Gly Trp  Ile Tyr Asp Met Glu  Asn Glu Ser 
    1250                 1255                 1260             


Asp Lys  Tyr Tyr Phe Asp Pro  Glu Thr Lys Lys Ala  Tyr Lys Gly 
    1265                 1270                 1275             


Ile Asn  Val Ile Asp Asp Ile  Lys Tyr Tyr Phe Asp  Glu Asn Gly 
    1280                 1285                 1290             


Ile Met  Arg Thr Gly Leu Ile  Thr Phe Glu Asp Asn  His Tyr Tyr 
    1295                 1300                 1305             


Phe Asn  Glu Asp Gly Ile Met  Gln Tyr Gly Tyr Leu  Asn Ile Glu 
    1310                 1315                 1320             


Asp Lys  Thr Phe Tyr Phe Ser  Glu Asp Gly Ile Met  Gln Ile Gly 
    1325                 1330                 1335             


Val Phe  Asn Thr Pro Asp Gly  Phe Lys Tyr Phe Ala  His Gln Asn 
    1340                 1345                 1350             


Thr Leu  Asp Glu Asn Phe Glu  Gly Glu Ser Ile Asn  Tyr Thr Gly 
    1355                 1360                 1365             


Trp Leu  Asp Leu Asp Glu Lys  Arg Tyr Tyr Phe Thr  Asp Glu Tyr 
    1370                 1375                 1380             


Ile Ala  Ala Thr Gly Ser Val  Ile Ile Asp Gly Glu  Glu Tyr Tyr 
    1385                 1390                 1395             


Phe Asp  Pro Asp Thr Ala Gln  Leu Val Ile Ser Glu  
    1400                 1405                 1410 


<210>  13
<211>  1600
<212>  PRT
<213>  Clostridium difficile

<400>  13

Ser Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro 
1               5                   10                  15      


Lys Glu Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser 
            20                  25                  30          


Thr Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu 
        35                  40                  45              


Leu Glu Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser 
    50                  55                  60                  


Asn Ile Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn 
65                  70                  75                  80  


Leu Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile 
                85                  90                  95      


Glu Ser Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu 
            100                 105                 110         


Glu Asp Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu 
        115                 120                 125             


Gly Phe Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe 
    130                 135                 140                 


Val Glu Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr 
145                 150                 155                 160 


Glu Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly 
                165                 170                 175     


Lys Leu Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr 
            180                 185                 190         


Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser 
        195                 200                 205             


Lys Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr 
    210                 215                 220                 


Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys 
225                 230                 235                 240 


Val Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu 
                245                 250                 255     


Pro Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly 
            260                 265                 270         


Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro 
        275                 280                 285             


Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val Asn 
    290                 295                 300                 


Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly Ile Ala 
305                 310                 315                 320 


Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile Ser Ala Gly 
                325                 330                 335     


Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg Asp Lys Ala Thr 
            340                 345                 350         


Lys Val Val Asp Tyr Phe Lys His Val Ser Leu Val Glu Thr Glu Gly 
        355                 360                 365             


Val Phe Thr Leu Leu Asp Asp Lys Ile Met Met Pro Gln Asp Asp Leu 
    370                 375                 380                 


Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Val Leu Gly Lys 
385                 390                 395                 400 


Cys Glu Ile Trp Arg Met Glu Gly Gly Ser Gly His Thr Val Thr Asp 
                405                 410                 415     


Asp Ile Asp His Phe Phe Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro 
            420                 425                 430         


His Leu Ser Ile Tyr Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp 
        435                 440                 445             


Leu Ser Lys Asp Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe 
    450                 455                 460                 


Ala Trp Glu Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp 
465                 470                 475                 480 


Gly Thr Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe 
                485                 490                 495     


Tyr Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu 
            500                 505                 510         


Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn 
        515                 520                 525             


Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg Glu 
    530                 535                 540                 


Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala Leu Ser 
545                 550                 555                 560 


Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser Glu Ser Asp 
                565                 570                 575     


Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp Val Thr Ile Glu 
            580                 585                 590         


Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu Gly Ile Leu Ser Thr 
        595                 600                 605             


Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu Asn Ser His Glu Ile Asn 
    610                 615                 620                 


Phe Ser Gly Glu Val Asn Gly Ser Asn Gly Phe Val Ser Leu Thr Phe 
625                 630                 635                 640 


Ser Ile Leu Glu Gly Ile Asn Ala Ile Ile Glu Val Asp Leu Leu Ser 
                645                 650                 655     


Lys Ser Tyr Lys Leu Leu Ile Ser Gly Glu Leu Lys Ile Leu Met Leu 
            660                 665                 670         


Asn Ser Asn His Ile Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser 
        675                 680                 685             


Glu Leu Gln Lys Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys 
    690                 695                 700                 


Glu Asn Gly Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser 
705                 710                 715                 720 


Glu Leu Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser 
                725                 730                 735     


Lys Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val 
            740                 745                 750         


Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp 
        755                 760                 765             


Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr Ile 
    770                 775                 780                 


Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu Ile Leu 
785                 790                 795                 800 


Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp Ser Leu Met 
                805                 810                 815     


Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe Val Asn Phe Leu 
            820                 825                 830         


Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn Phe Ile Ile Ser Gly 
        835                 840                 845             


Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile Cys Asp Glu Asn Asp Asn 
    850                 855                 860                 


Ile Gln Pro Tyr Phe Ile Lys Phe Asn Thr Leu Glu Thr Asn Tyr Thr 
865                 870                 875                 880 


Leu Tyr Val Gly Asn Arg Gln Asn Met Ile Val Glu Pro Asn Tyr Asp 
                885                 890                 895     


Leu Asp Asp Ser Gly Asp Ile Ser Ser Thr Val Ile Asn Phe Ser Gln 
            900                 905                 910         


Lys Tyr Leu Tyr Gly Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser 
        915                 920                 925             


Pro Asn Ile Tyr Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr 
    930                 935                 940                 


Asn Asn Thr Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn 
945                 950                 955                 960 


Glu Lys Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp 
                965                 970                 975     


Ser Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn 
            980                 985                 990         


Lys Val Ser Gln Val Lys Ile Arg  Phe Val Asn Val Phe  Lys Asp Lys 
        995                 1000                 1005             


Thr Leu  Ala Asn Lys Leu Ser  Phe Asn Phe Ser Asp  Lys Gln Asp 
    1010                 1015                 1020             


Val Pro  Val Ser Glu Ile Ile  Leu Ser Phe Thr Pro  Ser Tyr Tyr 
    1025                 1030                 1035             


Glu Asp  Gly Leu Ile Gly Tyr  Asp Leu Gly Leu Val  Ser Leu Tyr 
    1040                 1045                 1050             


Asn Glu  Lys Phe Tyr Ile Asn  Asn Phe Gly Met Met  Val Ser Gly 
    1055                 1060                 1065             


Leu Ile  Tyr Ile Asn Asp Ser  Leu Tyr Tyr Phe Lys  Pro Pro Val 
    1070                 1075                 1080             


Asn Asn  Leu Ile Thr Gly Phe  Val Thr Val Gly Asp  Asp Lys Tyr 
    1085                 1090                 1095             


Tyr Phe  Asn Pro Ile Asn Gly  Gly Ala Ala Ser Ile  Gly Glu Thr 
    1100                 1105                 1110             


Ile Ile  Asp Asp Lys Asn Tyr  Tyr Phe Asn Gln Ser  Gly Val Leu 
    1115                 1120                 1125             


Gln Thr  Gly Val Phe Ser Thr  Glu Asp Gly Phe Lys  Tyr Phe Ala 
    1130                 1135                 1140             


Pro Ala  Asn Thr Leu Asp Glu  Asn Leu Glu Gly Glu  Ala Ile Asp 
    1145                 1150                 1155             


Phe Thr  Gly Lys Leu Ile Ile  Asp Glu Asn Ile Tyr  Tyr Phe Asp 
    1160                 1165                 1170             


Asp Asn  Tyr Arg Gly Ala Val  Glu Trp Lys Glu Leu  Asp Gly Glu 
    1175                 1180                 1185             


Met His  Tyr Phe Ser Pro Glu  Thr Gly Lys Ala Phe  Lys Gly Leu 
    1190                 1195                 1200             


Asn Gln  Ile Gly Asp Tyr Lys  Tyr Tyr Phe Asn Ser  Asp Gly Val 
    1205                 1210                 1215             


Met Gln  Lys Gly Phe Val Ser  Ile Asn Asp Asn Lys  His Tyr Phe 
    1220                 1225                 1230             


Asp Asp  Ser Gly Val Met Lys  Val Gly Tyr Thr Glu  Ile Asp Gly 
    1235                 1240                 1245             


Lys His  Phe Tyr Phe Ala Glu  Asn Gly Glu Met Gln  Ile Gly Val 
    1250                 1255                 1260             


Phe Asn  Thr Glu Asp Gly Phe  Lys Tyr Phe Ala His  His Asn Glu 
    1265                 1270                 1275             


Asp Leu  Gly Asn Glu Glu Gly  Glu Glu Ile Ser Tyr  Ser Gly Ile 
    1280                 1285                 1290             


Leu Asn  Phe Asn Asn Lys Ile  Tyr Tyr Phe Asp Asp  Ser Phe Thr 
    1295                 1300                 1305             


Ala Val  Val Gly Trp Lys Asp  Leu Glu Asp Gly Ser  Lys Tyr Tyr 
    1310                 1315                 1320             


Phe Asp  Glu Asp Thr Ala Glu  Ala Tyr Ile Gly Leu  Ser Leu Ile 
    1325                 1330                 1335             


Asn Asp  Gly Gln Tyr Tyr Phe  Asn Asp Asp Gly Ile  Met Gln Val 
    1340                 1345                 1350             


Gly Phe  Val Thr Ile Asn Asp  Lys Val Phe Tyr Phe  Ser Asp Ser 
    1355                 1360                 1365             


Gly Ile  Ile Glu Ser Gly Val  Gln Asn Ile Asp Asp  Asn Tyr Phe 
    1370                 1375                 1380             


Tyr Ile  Asp Asp Asn Gly Ile  Val Gln Ile Gly Val  Phe Asp Thr 
    1385                 1390                 1395             


Ser Asp  Gly Tyr Lys Tyr Phe  Ala Pro Ala Asn Thr  Val Asn Asp 
    1400                 1405                 1410             


Asn Ile  Tyr Gly Gln Ala Val  Glu Tyr Ser Gly Leu  Val Arg Val 
    1415                 1420                 1425             


Gly Glu  Asp Val Tyr Tyr Phe  Gly Glu Thr Tyr Thr  Ile Glu Thr 
    1430                 1435                 1440             


Gly Trp  Ile Tyr Asp Met Glu  Asn Glu Ser Asp Lys  Tyr Tyr Phe 
    1445                 1450                 1455             


Asn Pro  Glu Thr Lys Lys Ala  Cys Lys Gly Ile Asn  Leu Ile Asp 
    1460                 1465                 1470             


Asp Ile  Lys Tyr Tyr Phe Asp  Glu Lys Gly Ile Met  Arg Thr Gly 
    1475                 1480                 1485             


Leu Ile  Ser Phe Glu Asn Asn  Asn Tyr Tyr Phe Asn  Glu Asn Gly 
    1490                 1495                 1500             


Glu Met  Gln Phe Gly Tyr Ile  Asn Ile Glu Asp Lys  Met Phe Tyr 
    1505                 1510                 1515             


Phe Gly  Glu Asp Gly Val Met  Gln Ile Gly Val Phe  Asn Thr Pro 
    1520                 1525                 1530             


Asp Gly  Phe Lys Tyr Phe Ala  His Gln Asn Thr Leu  Asp Glu Asn 
    1535                 1540                 1545             


Phe Glu  Gly Glu Ser Ile Asn  Tyr Thr Gly Trp Leu  Asp Leu Asp 
    1550                 1555                 1560             


Glu Lys  Arg Tyr Tyr Phe Thr  Asp Glu Tyr Ile Ala  Ala Thr Gly 
    1565                 1570                 1575             


Ser Val  Ile Ile Asp Gly Glu  Glu Tyr Tyr Phe Asp  Pro Asp Thr 
    1580                 1585                 1590             


Ala Gln  Leu Val Ile Ser Glu  
    1595                 1600 


<210>  14
<211>  1600
<212>  PRT
<213>  Clostridium difficile

<400>  14

Ser Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro 
1               5                   10                  15      


Lys Glu Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser 
            20                  25                  30          


Thr Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu 
        35                  40                  45              


Leu Glu Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser 
    50                  55                  60                  


Asn Ile Asp Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser 
65                  70                  75                  80  


Leu Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile 
                85                  90                  95      


Glu Ser Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu 
            100                 105                 110         


Glu Glu Ser His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu 
        115                 120                 125             


Gly Phe Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe 
    130                 135                 140                 


Val Glu Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr 
145                 150                 155                 160 


Glu Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly 
                165                 170                 175     


Lys Leu Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr 
            180                 185                 190         


Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser 
        195                 200                 205             


Lys Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr 
    210                 215                 220                 


Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys 
225                 230                 235                 240 


Val Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu 
                245                 250                 255     


Pro Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly 
            260                 265                 270         


Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro 
        275                 280                 285             


Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val Asn 
    290                 295                 300                 


Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly Ile Ala 
305                 310                 315                 320 


Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile Ser Ala Gly 
                325                 330                 335     


Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu Arg Asp Lys Ala Thr 
            340                 345                 350         


Lys Val Val Asp Tyr Phe Ser His Ile Ser Leu Ala Glu Ser Glu Gly 
        355                 360                 365             


Ala Phe Thr Ser Leu Asp Asp Lys Ile Met Met Pro Gln Asp Asp Leu 
    370                 375                 380                 


Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Thr Leu Gly Lys 
385                 390                 395                 400 


Cys Glu Ile Trp Arg Met Glu Gly Gly Ser Gly His Thr Val Thr Asp 
                405                 410                 415     


Asp Ile Asp His Phe Phe Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro 
            420                 425                 430         


His Leu Ser Ile Tyr Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp 
        435                 440                 445             


Leu Ser Lys Asp Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe 
    450                 455                 460                 


Ala Trp Glu Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp 
465                 470                 475                 480 


Gly Thr Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe 
                485                 490                 495     


Tyr Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu 
            500                 505                 510         


Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn 
        515                 520                 525             


Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile Arg Glu 
    530                 535                 540                 


Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala Leu Ser 
545                 550                 555                 560 


Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu Asn Glu Asn Asp 
                565                 570                 575     


Thr Trp Val Ile Asp Val Asp Asn Val Val Arg Asp Val Thr Ile Glu 
            580                 585                 590         


Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu Asn Ile Leu Ser Lys 
        595                 600                 605             


Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu Asp Asn His Glu Ile Asn 
    610                 615                 620                 


Phe Ser Gly Thr Leu Asn Gly Gly Asn Gly Phe Val Ser Leu Thr Phe 
625                 630                 635                 640 


Ser Ile Leu Glu Gly Ile Asn Ala Val Ile Glu Val Asp Leu Leu Ser 
                645                 650                 655     


Lys Ser Tyr Lys Val Leu Ile Ser Gly Glu Leu Lys Thr Leu Met Ala 
            660                 665                 670         


Asn Ser Asn Ser Val Gln Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser 
        675                 680                 685             


Glu Leu Gln Lys Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys 
    690                 695                 700                 


Glu Asn Gly Phe Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser 
705                 710                 715                 720 


Glu Leu Ser Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser 
                725                 730                 735     


Lys Pro Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val 
            740                 745                 750         


Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys Asp 
        755                 760                 765             


Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn Thr Ile 
    770                 775                 780                 


Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala Glu Ile Leu 
785                 790                 795                 800 


Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp Ser Leu Met 
                805                 810                 815     


Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe Ile Asn Ser Leu 
            820                 825                 830         


Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr Asn Phe Ile Ile Ser Gly 
        835                 840                 845             


Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile Cys Asp Lys Asp Asn Asn 
    850                 855                 860                 


Ile Gln Pro Tyr Phe Ile Lys Phe Asn Thr Leu Glu Thr Lys Tyr Thr 
865                 870                 875                 880 


Leu Tyr Val Gly Asn Arg Gln Asn Met Ile Val Glu Pro Asn Tyr Asp 
                885                 890                 895     


Leu Asp Asp Ser Gly Asp Ile Ser Ser Thr Val Ile Asn Phe Ser Gln 
            900                 905                 910         


Lys Tyr Leu Tyr Gly Ile Asp Ser Cys Val Asn Lys Val Ile Ile Ser 
        915                 920                 925             


Pro Asn Ile Tyr Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala 
    930                 935                 940                 


Asn Asn Thr Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser 
945                 950                 955                 960 


Glu Lys Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp 
                965                 970                 975     


Ser Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn 
            980                 985                 990         


Lys Val Ser Gln Val Lys Ile Arg  Phe Thr Asn Val Phe  Lys Gly Asn 
        995                 1000                 1005             


Thr Ile  Ser Asp Lys Ile Ser  Phe Asn Phe Ser Asp  Lys Gln Asp 
    1010                 1015                 1020             


Val Ser  Ile Asn Lys Val Ile  Ser Thr Phe Thr Pro  Ser Tyr Tyr 
    1025                 1030                 1035             


Val Glu  Gly Leu Leu Asn Tyr  Asp Leu Gly Leu Ile  Ser Leu Tyr 
    1040                 1045                 1050             


Asn Glu  Lys Phe Tyr Ile Asn  Asn Phe Gly Met Met  Val Ser Gly 
    1055                 1060                 1065             


Leu Val  Tyr Ile Asn Asp Ser  Leu Tyr Tyr Phe Lys  Pro Pro Ile 
    1070                 1075                 1080             


Lys Asn  Leu Ile Thr Gly Phe  Thr Thr Ile Gly Asp  Asp Lys Tyr 
    1085                 1090                 1095             


Tyr Phe  Asn Pro Asp Asn Gly  Gly Ala Ala Ser Val  Gly Glu Thr 
    1100                 1105                 1110             


Ile Ile  Asp Gly Lys Asn Tyr  Tyr Phe Ser Gln Asn  Gly Val Leu 
    1115                 1120                 1125             


Gln Thr  Gly Val Phe Ser Thr  Glu Asp Gly Phe Lys  Tyr Phe Ala 
    1130                 1135                 1140             


Pro Ala  Asp Thr Leu Asp Glu  Asn Leu Glu Gly Glu  Ala Ile Asp 
    1145                 1150                 1155             


Phe Thr  Gly Lys Leu Thr Ile  Asp Glu Asn Val Tyr  Tyr Phe Gly 
    1160                 1165                 1170             


Asp Asn  Tyr Arg Ala Ala Ile  Glu Trp Gln Thr Leu  Asp Asp Glu 
    1175                 1180                 1185             


Val Tyr  Tyr Phe Ser Thr Asp  Thr Gly Arg Ala Phe  Lys Gly Leu 
    1190                 1195                 1200             


Asn Gln  Ile Gly Asp Asp Lys  Phe Tyr Phe Asn Ser  Asp Gly Ile 
    1205                 1210                 1215             


Met Gln  Lys Gly Phe Val Asn  Ile Asn Asp Lys Thr  Phe Tyr Phe 
    1220                 1225                 1230             


Asp Asp  Ser Gly Val Met Lys  Ser Gly Tyr Thr Glu  Ile Asp Gly 
    1235                 1240                 1245             


Lys Tyr  Phe Tyr Phe Ala Glu  Asn Gly Glu Met Gln  Ile Gly Val 
    1250                 1255                 1260             


Phe Asn  Thr Ala Asp Gly Phe  Lys Tyr Phe Ala His  His Asp Glu 
    1265                 1270                 1275             


Asp Leu  Gly Asn Glu Glu Gly  Glu Ala Leu Ser Tyr  Ser Gly Ile 
    1280                 1285                 1290             


Leu Asn  Phe Asn Asn Lys Ile  Tyr Tyr Phe Asp Asp  Ser Phe Thr 
    1295                 1300                 1305             


Ala Val  Val Gly Trp Lys Asp  Leu Glu Asp Gly Ser  Lys Tyr Tyr 
    1310                 1315                 1320             


Phe Asp  Glu Asp Thr Ala Glu  Ala Tyr Ile Gly Ile  Ser Ile Ile 
    1325                 1330                 1335             


Asn Asp  Gly Lys Tyr Tyr Phe  Asn Asp Ser Gly Ile  Met Gln Ile 
    1340                 1345                 1350             


Gly Phe  Val Thr Ile Asn Asn  Glu Val Phe Tyr Phe  Ser Asp Ser 
    1355                 1360                 1365             


Gly Ile  Val Glu Ser Gly Met  Gln Asn Ile Asp Asp  Asn Tyr Phe 
    1370                 1375                 1380             


Tyr Ile  Asp Glu Asn Gly Leu  Val Gln Ile Gly Val  Phe Asp Thr 
    1385                 1390                 1395             


Ser Asp  Gly Tyr Lys Tyr Phe  Ala Pro Ala Asn Thr  Val Asn Asp 
    1400                 1405                 1410             


Asn Ile  Tyr Gly Gln Ala Val  Glu Tyr Ser Gly Leu  Val Arg Val 
    1415                 1420                 1425             


Gly Glu  Asp Val Tyr Tyr Phe  Gly Glu Thr Tyr Thr  Ile Glu Thr 
    1430                 1435                 1440             


Gly Trp  Ile Tyr Asp Met Glu  Asn Glu Ser Asp Lys  Tyr Tyr Phe 
    1445                 1450                 1455             


Asp Pro  Glu Thr Lys Lys Ala  Tyr Lys Gly Ile Asn  Val Ile Asp 
    1460                 1465                 1470             


Asp Ile  Lys Tyr Tyr Phe Asp  Glu Asn Gly Ile Met  Arg Thr Gly 
    1475                 1480                 1485             


Leu Ile  Thr Phe Glu Asp Asn  His Tyr Tyr Phe Asn  Glu Asp Gly 
    1490                 1495                 1500             


Ile Met  Gln Tyr Gly Tyr Leu  Asn Ile Glu Asp Lys  Thr Phe Tyr 
    1505                 1510                 1515             


Phe Ser  Glu Asp Gly Ile Met  Gln Ile Gly Val Phe  Asn Thr Pro 
    1520                 1525                 1530             


Asp Gly  Phe Lys Tyr Phe Ala  His Gln Asn Thr Leu  Asp Glu Asn 
    1535                 1540                 1545             


Phe Glu  Gly Glu Ser Ile Asn  Tyr Thr Gly Trp Leu  Asp Leu Asp 
    1550                 1555                 1560             


Glu Lys  Arg Tyr Tyr Phe Thr  Asp Glu Tyr Ile Ala  Ala Thr Gly 
    1565                 1570                 1575             


Ser Val  Ile Ile Asp Gly Glu  Glu Tyr Tyr Phe Asp  Pro Asp Thr 
    1580                 1585                 1590             


Ala Gln  Leu Val Ile Ser Glu  
    1595                 1600 


<210>  15
<211>  1756
<212>  PRT
<213>  Clostridium difficile

<400>  15

Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn 
1               5                   10                  15      


Ser Ser Lys Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln 
            20                  25                  30          


Val Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala 
        35                  40                  45              


Ala Lys Val Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp 
    50                  55                  60                  


Leu Leu Pro Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile 
65                  70                  75                  80  


Asp Gly Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser 
                85                  90                  95      


Asp Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala 
            100                 105                 110         


Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly 
        115                 120                 125             


Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile Ser 
    130                 135                 140                 


Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg Asp Lys 
145                 150                 155                 160 


Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu Val Glu Thr 
                165                 170                 175     


Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met Met Pro Gln Asp 
            180                 185                 190         


Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Val Leu 
        195                 200                 205             


Gly Lys Cys Glu Ile Trp Arg Met Glu Gly Gly Ser Gly His Thr Val 
    210                 215                 220                 


Thr Asp Asp Ile Asp His Phe Phe Ser Ala Pro Ser Ile Thr Tyr Arg 
225                 230                 235                 240 


Glu Pro His Leu Ser Ile Tyr Asp Val Leu Glu Val Gln Lys Glu Glu 
                245                 250                 255     


Leu Asp Leu Ser Lys Asp Leu Met Val Leu Pro Asn Ala Pro Asn Arg 
            260                 265                 270         


Val Phe Ala Trp Glu Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu 
        275                 280                 285             


Asn Asp Gly Thr Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly 
    290                 295                 300                 


Glu Phe Tyr Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr 
305                 310                 315                 320 


Thr Leu Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp 
                325                 330                 335     


Ser Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile 
            340                 345                 350         


Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala 
        355                 360                 365             


Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser Glu 
    370                 375                 380                 


Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp Val Thr 
385                 390                 395                 400 


Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu Gly Ile Leu 
                405                 410                 415     


Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu Asn Ser His Glu 
            420                 425                 430         


Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn Gly Phe Val Ser Leu 
        435                 440                 445             


Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala Ile Ile Glu Val Asp Leu 
    450                 455                 460                 


Leu Ser Lys Ser Tyr Lys Leu Leu Ile Ser Gly Glu Leu Lys Ile Leu 
465                 470                 475                 480 


Met Leu Asn Ser Asn His Ile Gln Gln Lys Ile Asp Tyr Ile Gly Phe 
                485                 490                 495     


Asn Ser Glu Leu Gln Lys Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu 
            500                 505                 510         


Gly Lys Glu Asn Gly Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe 
        515                 520                 525             


Val Ser Glu Leu Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp 
    530                 535                 540                 


Asp Ser Lys Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val 
545                 550                 555                 560 


Lys Val Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu 
                565                 570                 575     


Lys Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys 
            580                 585                 590         


Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu 
        595                 600                 605             


Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp Ser 
    610                 615                 620                 


Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe Val Asn 
625                 630                 635                 640 


Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn Phe Ile Ile 
                645                 650                 655     


Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile Cys Asp Glu Asn 
            660                 665                 670         


Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn Thr Leu Glu Thr Asn 
        675                 680                 685             


Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn Met Ile Val Glu Pro Asn 
    690                 695                 700                 


Tyr Asp Leu Asp Asp Ser Gly Asp Ile Ser Ser Thr Val Ile Asn Phe 
705                 710                 715                 720 


Ser Gln Lys Tyr Leu Tyr Gly Ile Asp Ser Cys Val Asn Lys Val Val 
                725                 730                 735     


Ile Ser Pro Asn Ile Tyr Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr 
            740                 745                 750         


Glu Thr Asn Asn Thr Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr 
        755                 760                 765             


Ile Asn Glu Lys Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr 
    770                 775                 780                 


Val Trp Ser Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu 
785                 790                 795                 800 


Glu Asn Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys 
                805                 810                 815     


Asp Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln 
            820                 825                 830         


Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr 
        835                 840                 845             


Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr Asn 
    850                 855                 860                 


Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly Leu Ile 
865                 870                 875                 880 


Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val Asn Asn Leu 
                885                 890                 895     


Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile 
            900                 905                 910         


Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile Asn Gly Lys His 
        915                 920                 925             


Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly Val Phe Lys Gly 
    930                 935                 940                 


Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Gln Asn Asn Asn 
945                 950                 955                 960 


Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn 
                965                 970                 975     


Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp 
            980                 985                 990         


Arg Ile Ile Asn Asn Glu Lys Tyr  Tyr Phe Asn Pro Asn  Asn Ala Ile 
        995                 1000                 1005             


Ala Ala  Val Gly Leu Gln Val  Ile Asp Asn Asn Lys  Tyr Tyr Phe 
    1010                 1015                 1020             


Asn Pro  Asp Thr Ala Ile Ile  Ser Lys Gly Trp Gln  Thr Val Asn 
    1025                 1030                 1035             


Gly Ser  Arg Tyr Tyr Phe Asp  Thr Asp Thr Ala Ile  Ala Phe Asn 
    1040                 1045                 1050             


Gly Tyr  Lys Thr Ile Asp Gly  Lys His Phe Tyr Phe  Asp Ser Asp 
    1055                 1060                 1065             


Cys Val  Val Lys Ile Gly Val  Phe Ser Thr Ser Asn  Gly Phe Glu 
    1070                 1075                 1080             


Tyr Phe  Ala Pro Ala Asn Thr  Tyr Asn Asn Asn Ile  Glu Gly Gln 
    1085                 1090                 1095             


Ala Ile  Val Tyr Gln Ser Lys  Phe Leu Thr Leu Asn  Gly Lys Lys 
    1100                 1105                 1110             


Tyr Tyr  Phe Asp Asn Asn Ser  Lys Ala Val Thr Gly  Trp Gln Thr 
    1115                 1120                 1125             


Ile Asp  Ser Lys Lys Tyr Tyr  Phe Asn Thr Asn Thr  Ala Glu Ala 
    1130                 1135                 1140             


Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn 
    1145                 1150                 1155             


Thr Asn  Thr Ala Glu Ala Ala  Thr Gly Trp Gln Thr  Ile Asp Gly 
    1160                 1165                 1170             


Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ala Ile Ala  Ser Thr Gly 
    1175                 1180                 1185             


Tyr Thr  Ile Ile Asn Gly Lys  His Phe Tyr Phe Asn  Thr Asp Gly 
    1190                 1195                 1200             


Ile Met  Gln Ile Gly Val Phe  Lys Gly Pro Asn Gly  Phe Glu Tyr 
    1205                 1210                 1215             


Phe Ala  Pro Ala Asn Thr Asp  Ala Asn Asn Ile Glu  Gly Gln Ala 
    1220                 1225                 1230             


Ile Leu  Tyr Gln Asn Glu Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr 
    1235                 1240                 1245             


Tyr Phe  Gly Ser Asp Ser Lys  Ala Val Thr Gly Trp  Arg Ile Ile 
    1250                 1255                 1260             


Asn Asn  Lys Lys Tyr Tyr Phe  Asn Pro Asn Asn Ala  Ile Ala Ala 
    1265                 1270                 1275             


Ile His  Leu Cys Thr Ile Asn  Asn Asp Lys Tyr Tyr  Phe Ser Tyr 
    1280                 1285                 1290             


Asp Gly  Ile Leu Gln Asn Gly  Tyr Ile Thr Ile Glu  Arg Asn Asn 
    1295                 1300                 1305             


Phe Tyr  Phe Asp Ala Asn Asn  Glu Ser Lys Met Val  Thr Gly Val 
    1310                 1315                 1320             


Phe Lys  Gly Pro Asn Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr 
    1325                 1330                 1335             


His Asn  Asn Asn Ile Glu Gly  Gln Ala Ile Val Tyr  Gln Asn Lys 
    1340                 1345                 1350             


Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr Phe Asp  Asn Asp Ser 
    1355                 1360                 1365             


Lys Ala  Val Thr Gly Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr 
    1370                 1375                 1380             


Phe Asn  Leu Asn Thr Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile 
    1385                 1390                 1395             


Asp Gly  Lys Lys Tyr Tyr Phe  Asn Leu Asn Thr Ala  Glu Ala Ala 
    1400                 1405                 1410             


Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr 
    1415                 1420                 1425             


Asn Thr  Phe Ile Ala Ser Thr  Gly Tyr Thr Ser Ile  Asn Gly Lys 
    1430                 1435                 1440             


His Phe  Tyr Phe Asn Thr Asp  Gly Ile Met Gln Ile  Gly Val Phe 
    1445                 1450                 1455             


Lys Gly  Pro Asn Gly Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr His 
    1460                 1465                 1470             


Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Leu Tyr Gln  Asn Lys Phe 
    1475                 1480                 1485             


Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe Gly Ser  Asp Ser Lys 
    1490                 1495                 1500             


Ala Val  Thr Gly Leu Arg Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe 
    1505                 1510                 1515             


Asn Thr  Asn Thr Ala Val Ala  Val Thr Gly Trp Gln  Thr Ile Asn 
    1520                 1525                 1530             


Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr Ser Ile  Ala Ser Thr 
    1535                 1540                 1545             


Gly Tyr  Thr Ile Ile Ser Gly  Lys His Phe Tyr Phe  Asn Thr Asp 
    1550                 1555                 1560             


Gly Ile  Met Gln Ile Gly Val  Phe Lys Gly Pro Asp  Gly Phe Glu 
    1565                 1570                 1575             


Tyr Phe  Ala Pro Ala Asn Thr  Asp Ala Asn Asn Ile  Glu Gly Gln 
    1580                 1585                 1590             


Ala Ile  Arg Tyr Gln Asn Arg  Phe Leu Tyr Leu His  Asp Asn Ile 
    1595                 1600                 1605             


Tyr Tyr  Phe Gly Asn Asn Ser  Lys Ala Ala Thr Gly  Trp Val Thr 
    1610                 1615                 1620             


Ile Asp  Gly Asn Arg Tyr Tyr  Phe Glu Pro Asn Thr  Ala Met Gly 
    1625                 1630                 1635             


Ala Asn  Gly Tyr Lys Thr Ile  Asp Asn Lys Asn Phe  Tyr Phe Arg 
    1640                 1645                 1650             


Asn Gly  Leu Pro Gln Ile Gly  Val Phe Lys Gly Ser  Asn Gly Phe 
    1655                 1660                 1665             


Glu Tyr  Phe Ala Pro Ala Asn  Thr Asp Ala Asn Asn  Ile Glu Gly 
    1670                 1675                 1680             


Gln Ala  Ile Arg Tyr Gln Asn  Arg Phe Leu His Leu  Leu Gly Lys 
    1685                 1690                 1695             


Ile Tyr  Tyr Phe Gly Asn Asn  Ser Lys Ala Val Thr  Gly Trp Gln 
    1700                 1705                 1710             


Thr Ile  Asn Gly Lys Val Tyr  Tyr Phe Met Pro Asp  Thr Ala Met 
    1715                 1720                 1725             


Ala Ala  Ala Gly Gly Leu Phe  Glu Ile Asp Gly Val  Ile Tyr Phe 
    1730                 1735                 1740             


Phe Gly  Val Asp Gly Val Lys  Ala Pro Gly Ile Tyr  Gly 
    1745                 1750                 1755     


<210>  16
<211>  1595
<212>  PRT
<213>  Clostridium difficile

<400>  16

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile 
1               5                   10                  15      


Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser 
            20                  25                  30          


Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro 
        35                  40                  45              


Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser 
    50                  55                  60                  


Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile 
65                  70                  75                  80  


Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu 
                85                  90                  95      


Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp 
            100                 105                 110         


Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr 
        115                 120                 125             


Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val 
    130                 135                 140                 


Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys 
145                 150                 155                 160 


Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn 
                165                 170                 175     


Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu 
            180                 185                 190         


Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys 
        195                 200                 205             


Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala 
    210                 215                 220                 


Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu 
225                 230                 235                 240 


Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu Pro 
                245                 250                 255     


Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp Gly Ile 
            260                 265                 270         


Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His Asp Pro Leu 
        275                 280                 285             


Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala Ile Asn Met 
    290                 295                 300                 


Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly Ile Gly Ala 
305                 310                 315                 320 


Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser Ala Gly Ile 
                325                 330                 335     


Pro Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys Ala Thr Ser 
            340                 345                 350         


Val Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Lys Tyr Gly Pro 
        355                 360                 365             


Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu Val 
    370                 375                 380                 


Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys 
385                 390                 395                 400 


Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn 
                405                 410                 415     


Ile Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser 
            420                 425                 430         


Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe 
        435                 440                 445             


Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp 
    450                 455                 460                 


Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly 
465                 470                 475                 480 


Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr 
                485                 490                 495     


Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys Pro 
            500                 505                 510         


Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp Thr Arg 
        515                 520                 525             


Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg Asn Lys Leu 
    530                 535                 540                 


Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu Ser 
545                 550                 555                 560 


Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp Asp Leu Trp 
                565                 570                 575     


Ile Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn Gly 
            580                 585                 590         


Thr Ile Lys Lys Gly Lys Leu Ile Lys Asp Val Leu Ser Lys Ile Asp 
        595                 600                 605             


Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser 
    610                 615                 620                 


Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu 
625                 630                 635                 640 


Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser 
                645                 650                 655     


Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu 
            660                 665                 670         


Ser Asn Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn 
        675                 680                 685             


Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala 
    690                 695                 700                 


Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser 
705                 710                 715                 720 


Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn Ser 
                725                 730                 735     


Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp Ile 
            740                 745                 750         


Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser 
        755                 760                 765             


Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val Asn 
    770                 775                 780                 


Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val 
785                 790                 795                 800 


Lys Asn Ser Asp Gly His His Asn Thr Ser Asn Phe Met Asn Leu Phe 
                805                 810                 815     


Leu Asp Asn Ile Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile Asn 
            820                 825                 830         


Phe Val Ile Asp Lys Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu Gly 
        835                 840                 845             


Tyr Val Glu Phe Ile Cys Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe 
    850                 855                 860                 


Gly Glu Trp Lys Thr Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn 
865                 870                 875                 880 


Gly Arg Asn Val Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu 
                885                 890                 895     


Asp Ile Ser Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile 
            900                 905                 910         


Asp Arg Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser 
        915                 920                 925             


Leu Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu 
    930                 935                 940                 


Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn 
945                 950                 955                 960 


Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser Asp 
                965                 970                 975     


Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu Gln 
            980                 985                 990         


Lys Ile Arg Ile Lys Gly Ile Leu  Ser Asn Thr Gln Ser  Phe Asn Lys 
        995                 1000                 1005             


Met Ser  Ile Asp Phe Lys Asp  Ile Lys Lys Leu Ser  Leu Gly Tyr 
    1010                 1015                 1020             


Ile Met  Ser Asn Phe Lys Ser  Phe Asn Ser Glu Asn  Glu Leu Asp 
    1025                 1030                 1035             


Arg Asp  His Leu Gly Phe Lys  Ile Ile Asp Asn Lys  Thr Tyr Tyr 
    1040                 1045                 1050             


Tyr Asp  Glu Asp Ser Lys Leu  Val Lys Gly Leu Ile  Asn Ile Asn 
    1055                 1060                 1065             


Asn Ser  Leu Phe Tyr Phe Asp  Pro Ile Glu Phe Asn  Leu Ile Thr 
    1070                 1075                 1080             


Gly Phe  Val Thr Val Gly Asp  Asp Lys Tyr Tyr Phe  Asn Pro Ile 
    1085                 1090                 1095             


Asn Gly  Gly Ala Ala Ser Ile  Gly Glu Thr Ile Ile  Asp Asp Lys 
    1100                 1105                 1110             


Asn Tyr  Tyr Phe Asn Gln Ser  Gly Val Leu Gln Thr  Gly Val Phe 
    1115                 1120                 1125             


Ser Thr  Glu Asp Gly Phe Lys  Tyr Phe Ala Pro Ala  Asn Thr Leu 
    1130                 1135                 1140             


Asp Glu  Asn Leu Glu Gly Glu  Ala Ile Asp Phe Thr  Gly Lys Leu 
    1145                 1150                 1155             


Ile Ile  Asp Glu Asn Ile Tyr  Tyr Phe Asp Asp Asn  Tyr Arg Gly 
    1160                 1165                 1170             


Ala Val  Glu Trp Lys Glu Leu  Asp Gly Glu Met His  Tyr Phe Ser 
    1175                 1180                 1185             


Pro Glu  Thr Gly Lys Ala Phe  Lys Gly Leu Asn Gln  Ile Gly Asp 
    1190                 1195                 1200             


Tyr Lys  Tyr Tyr Phe Asn Ser  Asp Gly Val Met Gln  Lys Gly Phe 
    1205                 1210                 1215             


Val Ser  Ile Asn Asp Asn Lys  His Tyr Phe Asp Asp  Ser Gly Val 
    1220                 1225                 1230             


Met Lys  Val Gly Tyr Thr Glu  Ile Asp Gly Lys His  Phe Tyr Phe 
    1235                 1240                 1245             


Ala Glu  Asn Gly Glu Met Gln  Ile Gly Val Phe Asn  Thr Glu Asp 
    1250                 1255                 1260             


Gly Phe  Lys Tyr Phe Ala His  His Asn Glu Asp Leu  Gly Asn Glu 
    1265                 1270                 1275             


Glu Gly  Glu Glu Ile Ser Tyr  Ser Gly Ile Leu Asn  Phe Asn Asn 
    1280                 1285                 1290             


Lys Ile  Tyr Tyr Phe Asp Asp  Ser Phe Thr Ala Val  Val Gly Trp 
    1295                 1300                 1305             


Lys Asp  Leu Glu Asp Gly Ser  Lys Tyr Tyr Phe Asp  Glu Asp Thr 
    1310                 1315                 1320             


Ala Glu  Ala Tyr Ile Gly Leu  Ser Leu Ile Asn Asp  Gly Gln Tyr 
    1325                 1330                 1335             


Tyr Phe  Asn Asp Asp Gly Ile  Met Gln Val Gly Phe  Val Thr Ile 
    1340                 1345                 1350             


Asn Asp  Lys Val Phe Tyr Phe  Ser Asp Ser Gly Ile  Ile Glu Ser 
    1355                 1360                 1365             


Gly Val  Gln Asn Ile Asp Asp  Asn Tyr Phe Tyr Ile  Asp Asp Asn 
    1370                 1375                 1380             


Gly Ile  Val Gln Ile Gly Val  Phe Asp Thr Ser Asp  Gly Tyr Lys 
    1385                 1390                 1395             


Tyr Phe  Ala Pro Ala Asn Thr  Val Asn Asp Asn Ile  Tyr Gly Gln 
    1400                 1405                 1410             


Ala Val  Glu Tyr Ser Gly Leu  Val Arg Val Gly Glu  Asp Val Tyr 
    1415                 1420                 1425             


Tyr Phe  Gly Glu Thr Tyr Thr  Ile Glu Thr Gly Trp  Ile Tyr Asp 
    1430                 1435                 1440             


Met Glu  Asn Glu Ser Asp Lys  Tyr Tyr Phe Asn Pro  Glu Thr Lys 
    1445                 1450                 1455             


Lys Ala  Cys Lys Gly Ile Asn  Leu Ile Asp Asp Ile  Lys Tyr Tyr 
    1460                 1465                 1470             


Phe Asp  Glu Lys Gly Ile Met  Arg Thr Gly Leu Ile  Ser Phe Glu 
    1475                 1480                 1485             


Asn Asn  Asn Tyr Tyr Phe Asn  Glu Asn Gly Glu Met  Gln Phe Gly 
    1490                 1495                 1500             


Tyr Ile  Asn Ile Glu Asp Lys  Met Phe Tyr Phe Gly  Glu Asp Gly 
    1505                 1510                 1515             


Val Met  Gln Ile Gly Val Phe  Asn Thr Pro Asp Gly  Phe Lys Tyr 
    1520                 1525                 1530             


Phe Ala  His Gln Asn Thr Leu  Asp Glu Asn Phe Glu  Gly Glu Ser 
    1535                 1540                 1545             


Ile Asn  Tyr Thr Gly Trp Leu  Asp Leu Asp Glu Lys  Arg Tyr Tyr 
    1550                 1555                 1560             


Phe Thr  Asp Glu Tyr Ile Ala  Ala Thr Gly Ser Val  Ile Ile Asp 
    1565                 1570                 1575             


Gly Glu  Glu Tyr Tyr Phe Asp  Pro Asp Thr Ala Gln  Leu Val Ile 
    1580                 1585                 1590             


Ser Glu  
    1595 


<210>  17
<211>  1595
<212>  PRT
<213>  Clostridium difficile

<400>  17

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile 
1               5                   10                  15      


Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser 
            20                  25                  30          


Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro 
        35                  40                  45              


Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser 
    50                  55                  60                  


Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile 
65                  70                  75                  80  


Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu 
                85                  90                  95      


Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp 
            100                 105                 110         


Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr 
        115                 120                 125             


Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val 
    130                 135                 140                 


Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys 
145                 150                 155                 160 


Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn 
                165                 170                 175     


Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu 
            180                 185                 190         


Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys 
        195                 200                 205             


Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala 
    210                 215                 220                 


Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu 
225                 230                 235                 240 


Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu Pro 
                245                 250                 255     


Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp Gly Ile 
            260                 265                 270         


Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His Asp Pro Leu 
        275                 280                 285             


Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala Ile Asn Met 
    290                 295                 300                 


Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly Ile Gly Ala 
305                 310                 315                 320 


Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser Ala Gly Ile 
                325                 330                 335     


Pro Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys Ala Thr Ser 
            340                 345                 350         


Val Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Lys Tyr Gly Pro 
        355                 360                 365             


Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu Val 
    370                 375                 380                 


Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys 
385                 390                 395                 400 


Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn 
                405                 410                 415     


Ile Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser 
            420                 425                 430         


Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe 
        435                 440                 445             


Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp 
    450                 455                 460                 


Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly 
465                 470                 475                 480 


Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr 
                485                 490                 495     


Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys Pro 
            500                 505                 510         


Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp Thr Arg 
        515                 520                 525             


Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg Asn Lys Leu 
    530                 535                 540                 


Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu Ser 
545                 550                 555                 560 


Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp Asp Leu Trp 
                565                 570                 575     


Ile Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn Gly 
            580                 585                 590         


Thr Ile Lys Lys Gly Lys Leu Ile Lys Asp Val Leu Ser Lys Ile Asp 
        595                 600                 605             


Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser 
    610                 615                 620                 


Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu 
625                 630                 635                 640 


Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser 
                645                 650                 655     


Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu 
            660                 665                 670         


Ser Asn Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn 
        675                 680                 685             


Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala 
    690                 695                 700                 


Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser 
705                 710                 715                 720 


Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn Ser 
                725                 730                 735     


Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp Ile 
            740                 745                 750         


Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser 
        755                 760                 765             


Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val Asn 
    770                 775                 780                 


Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val 
785                 790                 795                 800 


Lys Asn Ser Asp Gly His His Asn Thr Ser Asn Phe Met Asn Leu Phe 
                805                 810                 815     


Leu Asp Asn Ile Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile Asn 
            820                 825                 830         


Phe Val Ile Asp Lys Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu Gly 
        835                 840                 845             


Tyr Val Glu Phe Ile Cys Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe 
    850                 855                 860                 


Gly Glu Trp Lys Thr Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn 
865                 870                 875                 880 


Gly Arg Asn Val Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu 
                885                 890                 895     


Asp Ile Ser Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile 
            900                 905                 910         


Asp Arg Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser 
        915                 920                 925             


Leu Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu 
    930                 935                 940                 


Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn 
945                 950                 955                 960 


Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser Asp 
                965                 970                 975     


Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu Gln 
            980                 985                 990         


Lys Ile Arg Ile Lys Gly Ile Leu  Ser Asn Thr Gln Ser  Phe Asn Lys 
        995                 1000                 1005             


Met Ser  Ile Asp Phe Lys Asp  Ile Lys Lys Leu Ser  Leu Gly Tyr 
    1010                 1015                 1020             


Ile Met  Ser Asn Phe Lys Ser  Phe Asn Ser Glu Asn  Glu Leu Asp 
    1025                 1030                 1035             


Arg Asp  His Leu Gly Phe Lys  Ile Ile Asp Asn Lys  Thr Tyr Tyr 
    1040                 1045                 1050             


Tyr Asp  Glu Asp Ser Lys Leu  Val Lys Gly Leu Ile  Asn Ile Asn 
    1055                 1060                 1065             


Asn Ser  Leu Phe Tyr Phe Asp  Pro Ile Glu Phe Asn  Leu Ile Thr 
    1070                 1075                 1080             


Gly Phe  Thr Thr Ile Gly Asp  Asp Lys Tyr Tyr Phe  Asn Pro Asp 
    1085                 1090                 1095             


Asn Gly  Gly Ala Ala Ser Val  Gly Glu Thr Ile Ile  Asp Gly Lys 
    1100                 1105                 1110             


Asn Tyr  Tyr Phe Ser Gln Asn  Gly Val Leu Gln Thr  Gly Val Phe 
    1115                 1120                 1125             


Ser Thr  Glu Asp Gly Phe Lys  Tyr Phe Ala Pro Ala  Asp Thr Leu 
    1130                 1135                 1140             


Asp Glu  Asn Leu Glu Gly Glu  Ala Ile Asp Phe Thr  Gly Lys Leu 
    1145                 1150                 1155             


Thr Ile  Asp Glu Asn Val Tyr  Tyr Phe Gly Asp Asn  Tyr Arg Ala 
    1160                 1165                 1170             


Ala Ile  Glu Trp Gln Thr Leu  Asp Asp Glu Val Tyr  Tyr Phe Ser 
    1175                 1180                 1185             


Thr Asp  Thr Gly Arg Ala Phe  Lys Gly Leu Asn Gln  Ile Gly Asp 
    1190                 1195                 1200             


Asp Lys  Phe Tyr Phe Asn Ser  Asp Gly Ile Met Gln  Lys Gly Phe 
    1205                 1210                 1215             


Val Asn  Ile Asn Asp Lys Thr  Phe Tyr Phe Asp Asp  Ser Gly Val 
    1220                 1225                 1230             


Met Lys  Ser Gly Tyr Thr Glu  Ile Asp Gly Lys Tyr  Phe Tyr Phe 
    1235                 1240                 1245             


Ala Glu  Asn Gly Glu Met Gln  Ile Gly Val Phe Asn  Thr Ala Asp 
    1250                 1255                 1260             


Gly Phe  Lys Tyr Phe Ala His  His Asp Glu Asp Leu  Gly Asn Glu 
    1265                 1270                 1275             


Glu Gly  Glu Ala Leu Ser Tyr  Ser Gly Ile Leu Asn  Phe Asn Asn 
    1280                 1285                 1290             


Lys Ile  Tyr Tyr Phe Asp Asp  Ser Phe Thr Ala Val  Val Gly Trp 
    1295                 1300                 1305             


Lys Asp  Leu Glu Asp Gly Ser  Lys Tyr Tyr Phe Asp  Glu Asp Thr 
    1310                 1315                 1320             


Ala Glu  Ala Tyr Ile Gly Ile  Ser Ile Ile Asn Asp  Gly Lys Tyr 
    1325                 1330                 1335             


Tyr Phe  Asn Asp Ser Gly Ile  Met Gln Ile Gly Phe  Val Thr Ile 
    1340                 1345                 1350             


Asn Asn  Glu Val Phe Tyr Phe  Ser Asp Ser Gly Ile  Val Glu Ser 
    1355                 1360                 1365             


Gly Met  Gln Asn Ile Asp Asp  Asn Tyr Phe Tyr Ile  Asp Glu Asn 
    1370                 1375                 1380             


Gly Leu  Val Gln Ile Gly Val  Phe Asp Thr Ser Asp  Gly Tyr Lys 
    1385                 1390                 1395             


Tyr Phe  Ala Pro Ala Asn Thr  Val Asn Asp Asn Ile  Tyr Gly Gln 
    1400                 1405                 1410             


Ala Val  Glu Tyr Ser Gly Leu  Val Arg Val Gly Glu  Asp Val Tyr 
    1415                 1420                 1425             


Tyr Phe  Gly Glu Thr Tyr Thr  Ile Glu Thr Gly Trp  Ile Tyr Asp 
    1430                 1435                 1440             


Met Glu  Asn Glu Ser Asp Lys  Tyr Tyr Phe Asp Pro  Glu Thr Lys 
    1445                 1450                 1455             


Lys Ala  Tyr Lys Gly Ile Asn  Val Ile Asp Asp Ile  Lys Tyr Tyr 
    1460                 1465                 1470             


Phe Asp  Glu Asn Gly Ile Met  Arg Thr Gly Leu Ile  Thr Phe Glu 
    1475                 1480                 1485             


Asp Asn  His Tyr Tyr Phe Asn  Glu Asp Gly Ile Met  Gln Tyr Gly 
    1490                 1495                 1500             


Tyr Leu  Asn Ile Glu Asp Lys  Thr Phe Tyr Phe Ser  Glu Asp Gly 
    1505                 1510                 1515             


Ile Met  Gln Ile Gly Val Phe  Asn Thr Pro Asp Gly  Phe Lys Tyr 
    1520                 1525                 1530             


Phe Ala  His Gln Asn Thr Leu  Asp Glu Asn Phe Glu  Gly Glu Ser 
    1535                 1540                 1545             


Ile Asn  Tyr Thr Gly Trp Leu  Asp Leu Asp Glu Lys  Arg Tyr Tyr 
    1550                 1555                 1560             


Phe Thr  Asp Glu Tyr Ile Ala  Ala Thr Gly Ser Val  Ile Ile Asp 
    1565                 1570                 1575             


Gly Glu  Glu Tyr Tyr Phe Asp  Pro Asp Thr Ala Gln  Leu Val Ile 
    1580                 1585                 1590             


Ser Glu  
    1595 


<210>  18
<211>  2493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  18

His His His His His His Ser His Met Ala Ser Asn Lys Glu Ile Leu 
1               5                   10                  15      


Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu Pro Arg Glu Lys 
            20                  25                  30          


Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala Thr Lys Lys Lys 
        35                  40                  45              


Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp Arg Lys Ser Gly 
    50                  55                  60                  


Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp Glu Val Thr Gln 
65                  70                  75                  80  


Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr Glu Asp Glu Ser 
                85                  90                  95      


Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu Ser Val Thr Phe 
            100                 105                 110         


Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile Val Gln Lys Val 
        115                 120                 125             


Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe Arg Glu His Glu 
    130                 135                 140                 


Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn Arg Asp Asn Ile 
145                 150                 155                 160 


Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile Leu Arg Glu Asp 
                165                 170                 175     


Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg Val Arg Gly Val 
            180                 185                 190         


Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln Leu Phe Val Thr 
        195                 200                 205             


Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg Ile Glu Val Pro 
    210                 215                 220                 


Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala Ala Arg Asp Pro 
225                 230                 235                 240 


Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp Lys Arg Ile Asp 
                245                 250                 255     


Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg Val Gln Ala Val 
            260                 265                 270         


Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val Leu Trp Asp Asp 
        275                 280                 285             


Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro Ala Asp Val Ala 
    290                 295                 300                 


Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp Ile Ala Val Glu 
305                 310                 315                 320 


Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly Gln Asn Val Arg 
                325                 330                 335     


Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val Met Thr Val Asp 
            340                 345                 350         


Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala Ala Ile Asp Thr 
        355                 360                 365             


Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala Thr Val Leu Val 
    370                 375                 380                 


Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr Val Pro Met Lys 
385                 390                 395                 400 


Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr Val Glu Ala Leu 
                405                 410                 415     


Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala Gln Ala Gln Glu 
            420                 425                 430         


Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu Leu Asn Leu Glu 
        435                 440                 445             


Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala Arg Gly Val Cys 
    450                 455                 460                 


Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp Leu Ala Asp Ile 
465                 470                 475                 480 


Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile Met Ala Ala Arg 
                485                 490                 495     


Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala Leu Val Pro Arg 
            500                 505                 510         


Gly Ser Val Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro 
        515                 520                 525             


Phe Thr Met Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe 
    530                 535                 540                 


Asp Ser Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly 
545                 550                 555                 560 


Leu Ala Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser 
                565                 570                 575     


Val Ser Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile 
            580                 585                 590         


Glu Ser Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val 
        595                 600                 605             


Lys Asn Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn 
    610                 615                 620                 


Leu Leu Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn 
625                 630                 635                 640 


Asn Leu Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn 
                645                 650                 655     


Asn Ser Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser 
            660                 665                 670         


Val Tyr Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His 
        675                 680                 685             


Ile Thr Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val 
    690                 695                 700                 


Asn Gly Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val 
705                 710                 715                 720 


Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser 
                725                 730                 735     


Ser Asn Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln 
            740                 745                 750         


Leu Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser 
        755                 760                 765             


Ile Gln Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn 
    770                 775                 780                 


Val Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu 
785                 790                 795                 800 


Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His 
                805                 810                 815     


Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala 
            820                 825                 830         


Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly 
        835                 840                 845             


Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser 
    850                 855                 860                 


Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys 
865                 870                 875                 880 


Ala Thr Ser Val Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Lys 
                885                 890                 895     


Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp 
            900                 905                 910         


Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu 
        915                 920                 925             


Gly Thr Cys Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val 
    930                 935                 940                 


Thr Gly Asn Ile Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His 
945                 950                 955                 960 


Ile Pro Ser Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn 
                965                 970                 975     


Leu Asp Phe Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg 
            980                 985                 990         


Val Phe Trp Trp Glu Thr Gly Ala  Val Pro Gly Leu Arg  Ser Leu Glu 
        995                 1000                 1005             


Asn Asp  Gly Thr Arg Leu Leu  Asp Ser Ile Arg Asp  Leu Tyr Pro 
    1010                 1015                 1020             


Gly Lys  Phe Tyr Trp Arg Phe  Tyr Ala Phe Phe Asp  Tyr Ala Ile 
    1025                 1030                 1035             


Thr Thr  Leu Lys Pro Val Tyr  Glu Asp Thr Asn Ile  Lys Ile Lys 
    1040                 1045                 1050             


Leu Asp  Lys Asp Thr Arg Asn  Phe Ile Met Pro Thr  Ile Thr Thr 
    1055                 1060                 1065             


Asn Glu  Ile Arg Asn Lys Leu  Ser Tyr Ser Phe Asp  Gly Ala Gly 
    1070                 1075                 1080             


Gly Thr  Tyr Ser Leu Leu Leu  Ser Ser Tyr Pro Ile  Ser Thr Asn 
    1085                 1090                 1095             


Ile Asn  Leu Ser Lys Asp Asp  Leu Trp Ile Phe Asn  Ile Asp Asn 
    1100                 1105                 1110             


Glu Val  Arg Glu Ile Ser Ile  Glu Asn Gly Thr Ile  Lys Lys Gly 
    1115                 1120                 1125             


Lys Leu  Ile Lys Asp Val Leu  Ser Lys Ile Asp Ile  Asn Lys Asn 
    1130                 1135                 1140             


Lys Leu  Ile Ile Gly Asn Gln  Thr Ile Asp Phe Ser  Gly Asp Ile 
    1145                 1150                 1155             


Asp Asn  Lys Asp Arg Tyr Ile  Phe Leu Thr Cys Glu  Leu Asp Asp 
    1160                 1165                 1170             


Lys Ile  Ser Leu Ile Ile Glu  Ile Asn Leu Val Ala  Lys Ser Tyr 
    1175                 1180                 1185             


Ser Leu  Leu Leu Ser Gly Asp  Lys Asn Tyr Leu Ile  Ser Asn Leu 
    1190                 1195                 1200             


Ser Asn  Ile Ile Glu Lys Ile  Asn Thr Leu Gly Leu  Asp Ser Lys 
    1205                 1210                 1215             


Asn Ile  Ala Tyr Asn Tyr Thr  Asp Glu Ser Asn Asn  Lys Tyr Phe 
    1220                 1225                 1230             


Gly Ala  Ile Ser Lys Thr Ser  Gln Lys Ser Ile Ile  His Tyr Lys 
    1235                 1240                 1245             


Lys Asp  Ser Lys Asn Ile Leu  Glu Phe Tyr Asn Asp  Ser Thr Leu 
    1250                 1255                 1260             


Glu Phe  Asn Ser Lys Asp Phe  Ile Ala Glu Asp Ile  Asn Val Phe 
    1265                 1270                 1275             


Met Lys  Asp Asp Ile Asn Thr  Ile Thr Gly Lys Tyr  Tyr Val Asp 
    1280                 1285                 1290             


Asn Asn  Thr Asp Lys Ser Ile  Asp Phe Ser Ile Ser  Leu Val Ser 
    1295                 1300                 1305             


Lys Asn  Gln Val Lys Val Asn  Gly Leu Tyr Leu Asn  Glu Ser Val 
    1310                 1315                 1320             


Tyr Ser  Ser Tyr Leu Asp Phe  Val Lys Asn Ser Asp  Gly His His 
    1325                 1330                 1335             


Asn Thr  Ser Asn Phe Met Asn  Leu Phe Leu Asp Asn  Ile Ser Phe 
    1340                 1345                 1350             


Trp Lys  Leu Phe Gly Phe Glu  Asn Ile Asn Phe Val  Ile Asp Lys 
    1355                 1360                 1365             


Tyr Phe  Thr Leu Val Gly Lys  Thr Asn Leu Gly Tyr  Val Glu Phe 
    1370                 1375                 1380             


Ile Cys  Asp Asn Asn Lys Asn  Ile Asp Ile Tyr Phe  Gly Glu Trp 
    1385                 1390                 1395             


Lys Thr  Ser Ser Ser Lys Ser  Thr Ile Phe Ser Gly  Asn Gly Arg 
    1400                 1405                 1410             


Asn Val  Val Val Glu Pro Ile  Tyr Asn Pro Asp Thr  Gly Glu Asp 
    1415                 1420                 1425             


Ile Ser  Thr Ser Leu Asp Phe  Ser Tyr Glu Pro Leu  Tyr Gly Ile 
    1430                 1435                 1440             


Asp Arg  Tyr Ile Asn Lys Val  Leu Ile Ala Pro Asp  Leu Tyr Thr 
    1445                 1450                 1455             


Ser Leu  Ile Asn Ile Asn Thr  Asn Tyr Tyr Ser Asn  Glu Tyr Tyr 
    1460                 1465                 1470             


Pro Glu  Ile Ile Val Leu Asn  Pro Asn Thr Phe His  Lys Lys Val 
    1475                 1480                 1485             


Asn Ile  Asn Leu Asp Ser Ser  Ser Phe Glu Tyr Lys  Trp Ser Thr 
    1490                 1495                 1500             


Glu Gly  Ser Asp Phe Ile Leu  Val Arg Tyr Leu Glu  Glu Ser Asn 
    1505                 1510                 1515             


Lys Lys  Ile Leu Gln Lys Ile  Arg Ile Lys Gly Ile  Leu Ser Asn 
    1520                 1525                 1530             


Thr Gln  Ser Phe Asn Lys Met  Ser Ile Asp Phe Lys  Asp Ile Lys 
    1535                 1540                 1545             


Lys Leu  Ser Leu Gly Tyr Ile  Met Ser Asn Phe Lys  Ser Phe Asn 
    1550                 1555                 1560             


Ser Glu  Asn Glu Leu Asp Arg  Asp His Leu Gly Phe  Lys Ile Ile 
    1565                 1570                 1575             


Asp Asn  Lys Thr Tyr Tyr Tyr  Asp Glu Asp Ser Lys  Leu Val Lys 
    1580                 1585                 1590             


Gly Leu  Ile Asn Ile Asn Asn  Ser Leu Phe Tyr Phe  Asp Pro Ile 
    1595                 1600                 1605             


Glu Phe  Asn Leu Val Thr Gly  Trp Gln Thr Ile Asn  Gly Lys Lys 
    1610                 1615                 1620             


Tyr Tyr  Phe Asp Ile Asn Thr  Gly Ala Ala Leu Ile  Ser Tyr Lys 
    1625                 1630                 1635             


Ile Ile  Asn Gly Lys His Phe  Tyr Phe Asn Asn Asp  Gly Val Met 
    1640                 1645                 1650             


Gln Leu  Gly Val Phe Lys Gly  Pro Asp Gly Phe Glu  Tyr Phe Ala 
    1655                 1660                 1665             


Pro Ala  Asn Thr Gln Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Val 
    1670                 1675                 1680             


Tyr Gln  Ser Lys Phe Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe 
    1685                 1690                 1695             


Asp Asn  Asp Ser Lys Ala Val  Thr Gly Trp Arg Ile  Ile Asn Asn 
    1700                 1705                 1710             


Glu Lys  Tyr Tyr Phe Asn Pro  Asn Asn Ala Ile Ala  Ala Val Gly 
    1715                 1720                 1725             


Leu Gln  Val Ile Asp Asn Asn  Lys Tyr Tyr Phe Asn  Pro Asp Thr 
    1730                 1735                 1740             


Ala Ile  Ile Ser Lys Gly Trp  Gln Thr Val Asn Gly  Ser Arg Tyr 
    1745                 1750                 1755             


Tyr Phe  Asp Thr Asp Thr Ala  Ile Ala Phe Asn Gly  Tyr Lys Thr 
    1760                 1765                 1770             


Ile Asp  Gly Lys His Phe Tyr  Phe Asp Ser Asp Cys  Val Val Lys 
    1775                 1780                 1785             


Ile Gly  Val Phe Ser Thr Ser  Asn Gly Phe Glu Tyr  Phe Ala Pro 
    1790                 1795                 1800             


Ala Asn  Thr Tyr Asn Asn Asn  Ile Glu Gly Gln Ala  Ile Val Tyr 
    1805                 1810                 1815             


Gln Ser  Lys Phe Leu Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Asp 
    1820                 1825                 1830             


Asn Asn  Ser Lys Ala Val Thr  Gly Trp Gln Thr Ile  Asp Ser Lys 
    1835                 1840                 1845             


Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Glu Ala Ala  Thr Gly Trp 
    1850                 1855                 1860             


Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ala 
    1865                 1870                 1875             


Glu Ala  Ala Thr Gly Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr 
    1880                 1885                 1890             


Phe Asn  Thr Asn Thr Ala Ile  Ala Ser Thr Gly Tyr  Thr Ile Ile 
    1895                 1900                 1905             


Asn Gly  Lys His Phe Tyr Phe  Asn Thr Asp Gly Ile  Met Gln Ile 
    1910                 1915                 1920             


Gly Val  Phe Lys Gly Pro Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala 
    1925                 1930                 1935             


Asn Thr  Asp Ala Asn Asn Ile  Glu Gly Gln Ala Ile  Leu Tyr Gln 
    1940                 1945                 1950             


Asn Glu  Phe Leu Thr Leu Asn  Gly Lys Lys Tyr Tyr  Phe Gly Ser 
    1955                 1960                 1965             


Asp Ser  Lys Ala Val Thr Gly  Trp Arg Ile Ile Asn  Asn Lys Lys 
    1970                 1975                 1980             


Tyr Tyr  Phe Asn Pro Asn Asn  Ala Ile Ala Ala Ile  His Leu Cys 
    1985                 1990                 1995             


Thr Ile  Asn Asn Asp Lys Tyr  Tyr Phe Ser Tyr Asp  Gly Ile Leu 
    2000                 2005                 2010             


Gln Asn  Gly Tyr Ile Thr Ile  Glu Arg Asn Asn Phe  Tyr Phe Asp 
    2015                 2020                 2025             


Ala Asn  Asn Glu Ser Lys Met  Val Thr Gly Val Phe  Lys Gly Pro 
    2030                 2035                 2040             


Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn Thr His  Asn Asn Asn 
    2045                 2050                 2055             


Ile Glu  Gly Gln Ala Ile Val  Tyr Gln Asn Lys Phe  Leu Thr Leu 
    2060                 2065                 2070             


Asn Gly  Lys Lys Tyr Tyr Phe  Asp Asn Asp Ser Lys  Ala Val Thr 
    2075                 2080                 2085             


Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr Tyr Phe  Asn Leu Asn 
    2090                 2095                 2100             


Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys 
    2105                 2110                 2115             


Tyr Tyr  Phe Asn Leu Asn Thr  Ala Glu Ala Ala Thr  Gly Trp Gln 
    2120                 2125                 2130             


Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn Thr Asn  Thr Phe Ile 
    2135                 2140                 2145             


Ala Ser  Thr Gly Tyr Thr Ser  Ile Asn Gly Lys His  Phe Tyr Phe 
    2150                 2155                 2160             


Asn Thr  Asp Gly Ile Met Gln  Ile Gly Val Phe Lys  Gly Pro Asn 
    2165                 2170                 2175             


Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr His Asn  Asn Asn Ile 
    2180                 2185                 2190             


Glu Gly  Gln Ala Ile Leu Tyr  Gln Asn Lys Phe Leu  Thr Leu Asn 
    2195                 2200                 2205             


Gly Lys  Lys Tyr Tyr Phe Gly  Ser Asp Ser Lys Ala  Val Thr Gly 
    2210                 2215                 2220             


Leu Arg  Thr Ile Asp Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr 
    2225                 2230                 2235             


Ala Val  Ala Val Thr Gly Trp  Gln Thr Ile Asn Gly  Lys Lys Tyr 
    2240                 2245                 2250             


Tyr Phe  Asn Thr Asn Thr Ser  Ile Ala Ser Thr Gly  Tyr Thr Ile 
    2255                 2260                 2265             


Ile Ser  Gly Lys His Phe Tyr  Phe Asn Thr Asp Gly  Ile Met Gln 
    2270                 2275                 2280             


Ile Gly  Val Phe Lys Gly Pro  Asp Gly Phe Glu Tyr  Phe Ala Pro 
    2285                 2290                 2295             


Ala Asn  Thr Asp Ala Asn Asn  Ile Glu Gly Gln Ala  Ile Arg Tyr 
    2300                 2305                 2310             


Gln Asn  Arg Phe Leu Tyr Leu  His Asp Asn Ile Tyr  Tyr Phe Gly 
    2315                 2320                 2325             


Asn Asn  Ser Lys Ala Ala Thr  Gly Trp Val Thr Ile  Asp Gly Asn 
    2330                 2335                 2340             


Arg Tyr  Tyr Phe Glu Pro Asn  Thr Ala Met Gly Ala  Asn Gly Tyr 
    2345                 2350                 2355             


Lys Thr  Ile Asp Asn Lys Asn  Phe Tyr Phe Arg Asn  Gly Leu Pro 
    2360                 2365                 2370             


Gln Ile  Gly Val Phe Lys Gly  Ser Asn Gly Phe Glu  Tyr Phe Ala 
    2375                 2380                 2385             


Pro Ala  Asn Thr Asp Ala Asn  Asn Ile Glu Gly Gln  Ala Ile Arg 
    2390                 2395                 2400             


Tyr Gln  Asn Arg Phe Leu His  Leu Leu Gly Lys Ile  Tyr Tyr Phe 
    2405                 2410                 2415             


Gly Asn  Asn Ser Lys Ala Val  Thr Gly Trp Gln Thr  Ile Asn Gly 
    2420                 2425                 2430             


Lys Val  Tyr Tyr Phe Met Pro  Asp Thr Ala Met Ala  Ala Ala Gly 
    2435                 2440                 2445             


Gly Leu  Phe Glu Ile Asp Gly  Val Ile Tyr Phe Phe  Gly Val Asp 
    2450                 2455                 2460             


Gly Val  Lys Ala Pro Gly Ile  Tyr Gly Gly Gly Ser  Gly Gly Ser 
    2465                 2470                 2475             


Leu Val  Pro Arg Gly Ser Gly  Gly Ser His His His  His His His 
    2480                 2485                 2490             


<210>  19
<211>  2472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  19

His His His His His His Ser His Met Ala Ser Asn Lys Glu Ile Leu 
1               5                   10                  15      


Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu Pro Arg Glu Lys 
            20                  25                  30          


Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala Thr Lys Lys Lys 
        35                  40                  45              


Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp Arg Lys Ser Gly 
    50                  55                  60                  


Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp Glu Val Thr Gln 
65                  70                  75                  80  


Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr Glu Asp Glu Ser 
                85                  90                  95      


Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu Ser Val Thr Phe 
            100                 105                 110         


Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile Val Gln Lys Val 
        115                 120                 125             


Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe Arg Glu His Glu 
    130                 135                 140                 


Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn Arg Asp Asn Ile 
145                 150                 155                 160 


Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile Leu Arg Glu Asp 
                165                 170                 175     


Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg Val Arg Gly Val 
            180                 185                 190         


Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln Leu Phe Val Thr 
        195                 200                 205             


Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg Ile Glu Val Pro 
    210                 215                 220                 


Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala Ala Arg Asp Pro 
225                 230                 235                 240 


Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp Lys Arg Ile Asp 
                245                 250                 255     


Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg Val Gln Ala Val 
            260                 265                 270         


Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val Leu Trp Asp Asp 
        275                 280                 285             


Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro Ala Asp Val Ala 
    290                 295                 300                 


Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp Ile Ala Val Glu 
305                 310                 315                 320 


Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly Gln Asn Val Arg 
                325                 330                 335     


Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val Met Thr Val Asp 
            340                 345                 350         


Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala Ala Ile Asp Thr 
        355                 360                 365             


Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala Thr Val Leu Val 
    370                 375                 380                 


Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr Val Pro Met Lys 
385                 390                 395                 400 


Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr Val Glu Ala Leu 
                405                 410                 415     


Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala Gln Ala Gln Glu 
            420                 425                 430         


Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu Leu Asn Leu Glu 
        435                 440                 445             


Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala Arg Gly Val Cys 
    450                 455                 460                 


Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp Leu Ala Asp Ile 
465                 470                 475                 480 


Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile Met Ala Ala Arg 
                485                 490                 495     


Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala Leu Val Pro Arg 
            500                 505                 510         


Gly Ser Val Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro 
        515                 520                 525             


Phe Thr Met Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe 
    530                 535                 540                 


Asp Ser Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly 
545                 550                 555                 560 


Leu Ala Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser 
                565                 570                 575     


Val Ser Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile 
            580                 585                 590         


Glu Ser Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val 
        595                 600                 605             


Lys Asn Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn 
    610                 615                 620                 


Leu Leu Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn 
625                 630                 635                 640 


Asn Leu Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn 
                645                 650                 655     


Asn Ser Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser 
            660                 665                 670         


Val Tyr Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His 
        675                 680                 685             


Ile Thr Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val 
    690                 695                 700                 


Asn Gly Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val 
705                 710                 715                 720 


Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser 
                725                 730                 735     


Ser Asn Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln 
            740                 745                 750         


Leu Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser 
        755                 760                 765             


Ile Gln Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn 
    770                 775                 780                 


Val Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu 
785                 790                 795                 800 


Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His 
                805                 810                 815     


Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala 
            820                 825                 830         


Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly 
        835                 840                 845             


Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser 
    850                 855                 860                 


Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys 
865                 870                 875                 880 


Ala Thr Ser Val Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Lys 
                885                 890                 895     


Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp 
            900                 905                 910         


Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu 
        915                 920                 925             


Gly Thr Cys Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val 
    930                 935                 940                 


Thr Gly Asn Ile Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His 
945                 950                 955                 960 


Ile Pro Ser Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn 
                965                 970                 975     


Leu Asp Phe Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg 
            980                 985                 990         


Val Phe Trp Trp Glu Thr Gly Ala  Val Pro Gly Leu Arg  Ser Leu Glu 
        995                 1000                 1005             


Asn Asp  Gly Thr Arg Leu Leu  Asp Ser Ile Arg Asp  Leu Tyr Pro 
    1010                 1015                 1020             


Gly Lys  Phe Tyr Trp Arg Phe  Tyr Ala Phe Phe Asp  Tyr Ala Ile 
    1025                 1030                 1035             


Thr Thr  Leu Lys Pro Val Tyr  Glu Asp Thr Asn Ile  Lys Ile Lys 
    1040                 1045                 1050             


Leu Asp  Lys Asp Thr Arg Asn  Phe Ile Met Pro Thr  Ile Thr Thr 
    1055                 1060                 1065             


Asn Glu  Ile Arg Asn Lys Leu  Ser Tyr Ser Phe Asp  Gly Ala Gly 
    1070                 1075                 1080             


Gly Thr  Tyr Ser Leu Leu Leu  Ser Ser Tyr Pro Ile  Ser Thr Asn 
    1085                 1090                 1095             


Ile Asn  Leu Ser Lys Asp Asp  Leu Trp Ile Phe Asn  Ile Asp Asn 
    1100                 1105                 1110             


Glu Val  Arg Glu Ile Ser Ile  Glu Asn Gly Thr Ile  Lys Lys Gly 
    1115                 1120                 1125             


Lys Leu  Ile Lys Asp Val Leu  Ser Lys Ile Asp Ile  Asn Lys Asn 
    1130                 1135                 1140             


Lys Leu  Ile Ile Gly Asn Gln  Thr Ile Asp Phe Ser  Gly Asp Ile 
    1145                 1150                 1155             


Asp Asn  Lys Asp Arg Tyr Ile  Phe Leu Thr Cys Glu  Leu Asp Asp 
    1160                 1165                 1170             


Lys Ile  Ser Leu Ile Ile Glu  Ile Asn Leu Val Ala  Lys Ser Tyr 
    1175                 1180                 1185             


Ser Leu  Leu Leu Ser Gly Asp  Lys Asn Tyr Leu Ile  Ser Asn Leu 
    1190                 1195                 1200             


Ser Asn  Ile Ile Glu Lys Ile  Asn Thr Leu Gly Leu  Asp Ser Lys 
    1205                 1210                 1215             


Asn Ile  Ala Tyr Asn Tyr Thr  Asp Glu Ser Asn Asn  Lys Tyr Phe 
    1220                 1225                 1230             


Gly Ala  Ile Ser Lys Thr Ser  Gln Lys Ser Ile Ile  His Tyr Lys 
    1235                 1240                 1245             


Lys Asp  Ser Lys Asn Ile Leu  Glu Phe Tyr Asn Asp  Ser Thr Leu 
    1250                 1255                 1260             


Glu Phe  Asn Ser Lys Asp Phe  Ile Ala Glu Asp Ile  Asn Val Phe 
    1265                 1270                 1275             


Met Lys  Asp Asp Ile Asn Thr  Ile Thr Gly Lys Tyr  Tyr Val Asp 
    1280                 1285                 1290             


Asn Asn  Thr Asp Lys Ser Ile  Asp Phe Ser Ile Ser  Leu Val Ser 
    1295                 1300                 1305             


Lys Asn  Gln Val Lys Val Asn  Gly Leu Tyr Leu Asn  Glu Ser Val 
    1310                 1315                 1320             


Tyr Ser  Ser Tyr Leu Asp Phe  Val Lys Asn Ser Asp  Gly His His 
    1325                 1330                 1335             


Asn Thr  Ser Asn Phe Met Asn  Leu Phe Leu Asp Asn  Ile Ser Phe 
    1340                 1345                 1350             


Trp Lys  Leu Phe Gly Phe Glu  Asn Ile Asn Phe Val  Ile Asp Lys 
    1355                 1360                 1365             


Tyr Phe  Thr Leu Val Gly Lys  Thr Asn Leu Gly Tyr  Val Glu Phe 
    1370                 1375                 1380             


Ile Cys  Asp Asn Asn Lys Asn  Ile Asp Ile Tyr Phe  Gly Glu Trp 
    1385                 1390                 1395             


Lys Thr  Ser Ser Ser Lys Ser  Thr Ile Phe Ser Gly  Asn Gly Arg 
    1400                 1405                 1410             


Asn Val  Val Val Glu Pro Ile  Tyr Asn Pro Asp Thr  Gly Glu Asp 
    1415                 1420                 1425             


Ile Ser  Thr Ser Leu Asp Phe  Ser Tyr Glu Pro Leu  Tyr Gly Ile 
    1430                 1435                 1440             


Asp Arg  Tyr Ile Asn Lys Val  Leu Ile Ala Pro Asp  Leu Tyr Thr 
    1445                 1450                 1455             


Ser Leu  Ile Asn Ile Asn Thr  Asn Tyr Tyr Ser Asn  Glu Tyr Tyr 
    1460                 1465                 1470             


Pro Glu  Ile Ile Val Leu Asn  Pro Asn Thr Phe His  Lys Lys Val 
    1475                 1480                 1485             


Asn Ile  Asn Leu Asp Ser Ser  Ser Phe Glu Tyr Lys  Trp Ser Thr 
    1490                 1495                 1500             


Glu Gly  Ser Asp Phe Ile Leu  Val Arg Tyr Leu Glu  Glu Ser Asn 
    1505                 1510                 1515             


Lys Lys  Ile Leu Gln Lys Ile  Arg Ile Lys Gly Ile  Leu Ser Asn 
    1520                 1525                 1530             


Thr Gln  Ser Phe Asn Lys Met  Ser Ile Asp Phe Lys  Asp Ile Lys 
    1535                 1540                 1545             


Lys Leu  Ser Leu Gly Tyr Ile  Met Ser Asn Phe Lys  Ser Phe Asn 
    1550                 1555                 1560             


Ser Glu  Asn Glu Leu Asp Arg  Asp His Leu Gly Phe  Lys Ile Ile 
    1565                 1570                 1575             


Asp Asn  Lys Thr Tyr Tyr Tyr  Asp Glu Asp Ser Lys  Leu Val Lys 
    1580                 1585                 1590             


Gly Leu  Ile Asn Ile Asn Asn  Ser Leu Phe Tyr Phe  Asp Pro Ile 
    1595                 1600                 1605             


Glu Phe  Asn Leu Val Thr Gly  Trp Gln Thr Ile Asn  Gly Lys Lys 
    1610                 1615                 1620             


Tyr Tyr  Phe Asp Ile Asn Thr  Gly Ala Ala Leu Ile  Ser Tyr Lys 
    1625                 1630                 1635             


Ile Ile  Asn Gly Lys His Phe  Tyr Phe Asn Asn Asp  Gly Val Met 
    1640                 1645                 1650             


Gln Leu  Gly Val Phe Lys Gly  Pro Asp Gly Phe Glu  Tyr Phe Ala 
    1655                 1660                 1665             


Pro Ala  Asn Thr Gln Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Val 
    1670                 1675                 1680             


Tyr Gln  Ser Lys Phe Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe 
    1685                 1690                 1695             


Asp Asn  Asp Ser Lys Ala Val  Thr Gly Trp Arg Ile  Ile Asn Asn 
    1700                 1705                 1710             


Glu Lys  Tyr Tyr Phe Asn Pro  Asn Asn Ala Ile Ala  Ala Val Gly 
    1715                 1720                 1725             


Leu Gln  Val Ile Asp Asn Asn  Lys Tyr Tyr Phe Asn  Pro Asp Thr 
    1730                 1735                 1740             


Ala Ile  Ile Ser Lys Gly Trp  Gln Thr Val Asn Gly  Ser Arg Tyr 
    1745                 1750                 1755             


Tyr Phe  Asp Thr Asp Thr Ala  Ile Ala Phe Asn Gly  Tyr Lys Thr 
    1760                 1765                 1770             


Ile Asp  Gly Lys His Phe Tyr  Phe Asp Ser Asp Cys  Val Val Lys 
    1775                 1780                 1785             


Ile Gly  Val Phe Ser Thr Ser  Asn Gly Phe Glu Tyr  Phe Ala Pro 
    1790                 1795                 1800             


Ala Asn  Thr Tyr Asn Asn Asn  Ile Glu Gly Gln Ala  Ile Val Tyr 
    1805                 1810                 1815             


Gln Ser  Lys Phe Leu Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Asp 
    1820                 1825                 1830             


Asn Asn  Ser Lys Ala Val Thr  Gly Trp Gln Thr Ile  Asp Ser Lys 
    1835                 1840                 1845             


Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Glu Ala Ala  Thr Gly Trp 
    1850                 1855                 1860             


Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ala 
    1865                 1870                 1875             


Glu Ala  Ala Thr Gly Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr 
    1880                 1885                 1890             


Phe Asn  Thr Asn Thr Ala Ile  Ala Ser Thr Gly Tyr  Thr Ile Ile 
    1895                 1900                 1905             


Asn Gly  Lys His Phe Tyr Phe  Asn Thr Asp Gly Ile  Met Gln Ile 
    1910                 1915                 1920             


Gly Val  Phe Lys Gly Pro Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala 
    1925                 1930                 1935             


Asn Thr  Asp Ala Asn Asn Ile  Glu Gly Gln Ala Ile  Leu Tyr Gln 
    1940                 1945                 1950             


Asn Glu  Phe Leu Thr Leu Asn  Gly Lys Lys Tyr Tyr  Phe Gly Ser 
    1955                 1960                 1965             


Asp Ser  Lys Ala Val Thr Gly  Trp Arg Ile Ile Asn  Asn Lys Lys 
    1970                 1975                 1980             


Tyr Tyr  Phe Asn Pro Asn Asn  Ala Ile Ala Ala Ile  His Leu Cys 
    1985                 1990                 1995             


Thr Ile  Asn Asn Asp Lys Tyr  Tyr Phe Ser Tyr Asp  Gly Ile Leu 
    2000                 2005                 2010             


Gln Asn  Gly Tyr Ile Thr Ile  Glu Arg Asn Asn Phe  Tyr Phe Asp 
    2015                 2020                 2025             


Ala Asn  Asn Glu Ser Lys Met  Val Thr Gly Val Phe  Lys Gly Pro 
    2030                 2035                 2040             


Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn Thr His  Asn Asn Asn 
    2045                 2050                 2055             


Ile Glu  Gly Gln Ala Ile Val  Tyr Gln Asn Lys Phe  Leu Thr Leu 
    2060                 2065                 2070             


Asn Gly  Lys Lys Tyr Tyr Phe  Asp Asn Asp Ser Lys  Ala Val Thr 
    2075                 2080                 2085             


Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr Tyr Phe  Asn Leu Asn 
    2090                 2095                 2100             


Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys 
    2105                 2110                 2115             


Tyr Tyr  Phe Asn Leu Asn Thr  Ala Glu Ala Ala Thr  Gly Trp Gln 
    2120                 2125                 2130             


Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn Thr Asn  Thr Phe Ile 
    2135                 2140                 2145             


Ala Ser  Thr Gly Tyr Thr Ser  Ile Asn Gly Lys His  Phe Tyr Phe 
    2150                 2155                 2160             


Asn Thr  Asp Gly Ile Met Gln  Ile Gly Val Phe Lys  Gly Pro Asn 
    2165                 2170                 2175             


Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr His Asn  Asn Asn Ile 
    2180                 2185                 2190             


Glu Gly  Gln Ala Ile Leu Tyr  Gln Asn Lys Phe Leu  Thr Leu Asn 
    2195                 2200                 2205             


Gly Lys  Lys Tyr Tyr Phe Gly  Ser Asp Ser Lys Ala  Val Thr Gly 
    2210                 2215                 2220             


Leu Arg  Thr Ile Asp Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr 
    2225                 2230                 2235             


Ala Val  Ala Val Thr Gly Trp  Gln Thr Ile Asn Gly  Lys Lys Tyr 
    2240                 2245                 2250             


Tyr Phe  Asn Thr Asn Thr Ser  Ile Ala Ser Thr Gly  Tyr Thr Ile 
    2255                 2260                 2265             


Ile Ser  Gly Lys His Phe Tyr  Phe Asn Thr Asp Gly  Ile Met Gln 
    2270                 2275                 2280             


Ile Gly  Val Phe Lys Gly Pro  Asp Gly Phe Glu Tyr  Phe Ala Pro 
    2285                 2290                 2295             


Ala Asn  Thr Asp Ala Asn Asn  Ile Glu Gly Gln Ala  Ile Arg Tyr 
    2300                 2305                 2310             


Gln Asn  Arg Phe Leu Tyr Leu  His Asp Asn Ile Tyr  Tyr Phe Gly 
    2315                 2320                 2325             


Asn Asn  Ser Lys Ala Ala Thr  Gly Trp Val Thr Ile  Asp Gly Asn 
    2330                 2335                 2340             


Arg Tyr  Tyr Phe Glu Pro Asn  Thr Ala Met Gly Ala  Asn Gly Tyr 
    2345                 2350                 2355             


Lys Thr  Ile Asp Asn Lys Asn  Phe Tyr Phe Arg Asn  Gly Leu Pro 
    2360                 2365                 2370             


Gln Ile  Gly Val Phe Lys Gly  Ser Asn Gly Phe Glu  Tyr Phe Ala 
    2375                 2380                 2385             


Pro Ala  Asn Thr Asp Ala Asn  Asn Ile Glu Gly Gln  Ala Ile Arg 
    2390                 2395                 2400             


Tyr Gln  Asn Arg Phe Leu His  Leu Leu Gly Lys Ile  Tyr Tyr Phe 
    2405                 2410                 2415             


Gly Asn  Asn Ser Lys Ala Val  Thr Gly Trp Gln Thr  Ile Asn Gly 
    2420                 2425                 2430             


Lys Val  Tyr Tyr Phe Met Pro  Asp Thr Ala Met Ala  Ala Ala Gly 
    2435                 2440                 2445             


Gly Leu  Phe Glu Ile Asp Gly  Val Ile Tyr Phe Phe  Gly Val Asp 
    2450                 2455                 2460             


Gly Val  Lys Ala Pro Gly Ile  Tyr Gly 
    2465                 2470         


<210>  20
<211>  2084
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  20

His His His His His His Ser His Met Ala Ser Asp Lys Ile Ile His 
1               5                   10                  15      


Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp Gly Ala 
            20                  25                  30          


Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys Met Ile 
        35                  40                  45              


Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys Leu Thr 
    50                  55                  60                  


Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro Lys Tyr 
65                  70                  75                  80  


Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly Glu Val 
                85                  90                  95      


Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys Glu Phe 
            100                 105                 110         


Leu Asp Ala Asn Leu Ala Arg Ala Leu Val Pro Arg Gly Ser Val Thr 
        115                 120                 125             


Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro Phe Thr Met Ile 
    130                 135                 140                 


Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile Asp 
145                 150                 155                 160 


Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser Ile 
                165                 170                 175     


Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro Asp 
            180                 185                 190         


Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser Ile 
        195                 200                 205             


Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile Ile 
    210                 215                 220                 


His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu Asn 
225                 230                 235                 240 


Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp Glu 
                245                 250                 255     


Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr Tyr 
            260                 265                 270         


Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val Glu 
        275                 280                 285             


Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys Glu 
    290                 295                 300                 


Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn Leu 
305                 310                 315                 320 


Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu Asn 
                325                 330                 335     


Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys Asp 
            340                 345                 350         


Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala Gln 
        355                 360                 365             


Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu Val 
    370                 375                 380                 


Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu Pro Thr 
385                 390                 395                 400 


Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp Gly Ile Asn 
                405                 410                 415     


Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His Asp Pro Leu Leu 
            420                 425                 430         


Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala Ile Asn Met Ser 
        435                 440                 445             


Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly Ile Gly Ala Glu 
    450                 455                 460                 


Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser Ala Gly Ile Pro 
465                 470                 475                 480 


Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys Ala Thr Ser Val 
                485                 490                 495     


Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu 
            500                 505                 510         


Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile 
        515                 520                 525             


Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn 
    530                 535                 540                 


Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile 
545                 550                 555                 560 


Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu 
                565                 570                 575     


Ser Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser 
            580                 585                 590         


Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp 
        595                 600                 605             


Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr 
    610                 615                 620                 


Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr Trp 
625                 630                 635                 640 


Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys Pro Val 
                645                 650                 655     


Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp Thr Arg Asn 
            660                 665                 670         


Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg Asn Lys Leu Ser 
        675                 680                 685             


Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu Ser Ser 
    690                 695                 700                 


Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp Asp Leu Trp Ile 
705                 710                 715                 720 


Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn Gly Thr 
                725                 730                 735     


Ile Lys Lys Gly Lys Leu Ile Lys Asp Val Leu Ser Lys Ile Asp Ile 
            740                 745                 750         


Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly 
        755                 760                 765             


Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp 
    770                 775                 780                 


Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr 
785                 790                 795                 800 


Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser 
                805                 810                 815     


Asn Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile 
            820                 825                 830         


Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile 
        835                 840                 845             


Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser Lys 
    850                 855                 860                 


Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn Ser Lys 
865                 870                 875                 880 


Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp Ile Asn 
                885                 890                 895     


Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser Ile 
            900                 905                 910         


Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val Asn Gly 
        915                 920                 925             


Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val Lys 
    930                 935                 940                 


Asn Ser Asp Gly His His Asn Thr Ser Asn Phe Met Asn Leu Phe Leu 
945                 950                 955                 960 


Asp Asn Ile Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile Asn Phe 
                965                 970                 975     


Val Ile Asp Lys Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr 
            980                 985                 990         


Val Glu Phe Ile Cys Asp Asn Asn  Lys Asn Ile Asp Ile  Tyr Phe Gly 
        995                 1000                 1005             


Glu Trp  Lys Thr Ser Ser Ser  Lys Ser Thr Ile Phe  Ser Gly Asn 
    1010                 1015                 1020             


Gly Arg  Asn Val Val Val Glu  Pro Ile Tyr Asn Pro  Asp Thr Gly 
    1025                 1030                 1035             


Glu Asp  Ile Ser Thr Ser Leu  Asp Phe Ser Tyr Glu  Pro Leu Tyr 
    1040                 1045                 1050             


Gly Ile  Asp Arg Tyr Ile Asn  Lys Val Leu Ile Ala  Pro Asp Leu 
    1055                 1060                 1065             


Tyr Thr  Ser Leu Ile Asn Ile  Asn Thr Asn Tyr Tyr  Ser Asn Glu 
    1070                 1075                 1080             


Tyr Tyr  Pro Glu Ile Ile Val  Leu Asn Pro Asn Thr  Phe His Lys 
    1085                 1090                 1095             


Lys Val  Asn Ile Asn Leu Asp  Ser Ser Ser Phe Glu  Tyr Lys Trp 
    1100                 1105                 1110             


Ser Thr  Glu Gly Ser Asp Phe  Ile Leu Val Arg Tyr  Leu Glu Glu 
    1115                 1120                 1125             


Ser Asn  Lys Lys Ile Leu Gln  Lys Ile Arg Ile Lys  Gly Ile Leu 
    1130                 1135                 1140             


Ser Asn  Thr Gln Ser Phe Asn  Lys Met Ser Ile Asp  Phe Lys Asp 
    1145                 1150                 1155             


Ile Lys  Lys Leu Ser Leu Gly  Tyr Ile Met Ser Asn  Phe Lys Ser 
    1160                 1165                 1170             


Phe Asn  Ser Glu Asn Glu Leu  Asp Arg Asp His Leu  Gly Phe Lys 
    1175                 1180                 1185             


Ile Ile  Asp Asn Lys Thr Tyr  Tyr Tyr Asp Glu Asp  Ser Lys Leu 
    1190                 1195                 1200             


Val Lys  Gly Leu Ile Asn Ile  Asn Asn Ser Leu Phe  Tyr Phe Asp 
    1205                 1210                 1215             


Pro Ile  Glu Phe Asn Leu Val  Thr Gly Trp Gln Thr  Ile Asn Gly 
    1220                 1225                 1230             


Lys Lys  Tyr Tyr Phe Asp Ile  Asn Thr Gly Ala Ala  Leu Ile Ser 
    1235                 1240                 1245             


Tyr Lys  Ile Ile Asn Gly Lys  His Phe Tyr Phe Asn  Asn Asp Gly 
    1250                 1255                 1260             


Val Met  Gln Leu Gly Val Phe  Lys Gly Pro Asp Gly  Phe Glu Tyr 
    1265                 1270                 1275             


Phe Ala  Pro Ala Asn Thr Gln  Asn Asn Asn Ile Glu  Gly Gln Ala 
    1280                 1285                 1290             


Ile Val  Tyr Gln Ser Lys Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr 
    1295                 1300                 1305             


Tyr Phe  Asp Asn Asp Ser Lys  Ala Val Thr Gly Trp  Arg Ile Ile 
    1310                 1315                 1320             


Asn Asn  Glu Lys Tyr Tyr Phe  Asn Pro Asn Asn Ala  Ile Ala Ala 
    1325                 1330                 1335             


Val Gly  Leu Gln Val Ile Asp  Asn Asn Lys Tyr Tyr  Phe Asn Pro 
    1340                 1345                 1350             


Asp Thr  Ala Ile Ile Ser Lys  Gly Trp Gln Thr Val  Asn Gly Ser 
    1355                 1360                 1365             


Arg Tyr  Tyr Phe Asp Thr Asp  Thr Ala Ile Ala Phe  Asn Gly Tyr 
    1370                 1375                 1380             


Lys Thr  Ile Asp Gly Lys His  Phe Tyr Phe Asp Ser  Asp Cys Val 
    1385                 1390                 1395             


Val Lys  Ile Gly Val Phe Ser  Thr Ser Asn Gly Phe  Glu Tyr Phe 
    1400                 1405                 1410             


Ala Pro  Ala Asn Thr Tyr Asn  Asn Asn Ile Glu Gly  Gln Ala Ile 
    1415                 1420                 1425             


Val Tyr  Gln Ser Lys Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr 
    1430                 1435                 1440             


Phe Asp  Asn Asn Ser Lys Ala  Val Thr Gly Trp Gln  Thr Ile Asp 
    1445                 1450                 1455             


Ser Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr Ala Glu  Ala Ala Thr 
    1460                 1465                 1470             


Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn 
    1475                 1480                 1485             


Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys 
    1490                 1495                 1500             


Tyr Tyr  Phe Asn Thr Asn Thr  Ala Ile Ala Ser Thr  Gly Tyr Thr 
    1505                 1510                 1515             


Ile Ile  Asn Gly Lys His Phe  Tyr Phe Asn Thr Asp  Gly Ile Met 
    1520                 1525                 1530             


Gln Ile  Gly Val Phe Lys Gly  Pro Asn Gly Phe Glu  Tyr Phe Ala 
    1535                 1540                 1545             


Pro Ala  Asn Thr Asp Ala Asn  Asn Ile Glu Gly Gln  Ala Ile Leu 
    1550                 1555                 1560             


Tyr Gln  Asn Glu Phe Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe 
    1565                 1570                 1575             


Gly Ser  Asp Ser Lys Ala Val  Thr Gly Trp Arg Ile  Ile Asn Asn 
    1580                 1585                 1590             


Lys Lys  Tyr Tyr Phe Asn Pro  Asn Asn Ala Ile Ala  Ala Ile His 
    1595                 1600                 1605             


Leu Cys  Thr Ile Asn Asn Asp  Lys Tyr Tyr Phe Ser  Tyr Asp Gly 
    1610                 1615                 1620             


Ile Leu  Gln Asn Gly Tyr Ile  Thr Ile Glu Arg Asn  Asn Phe Tyr 
    1625                 1630                 1635             


Phe Asp  Ala Asn Asn Glu Ser  Lys Met Val Thr Gly  Val Phe Lys 
    1640                 1645                 1650             


Gly Pro  Asn Gly Phe Glu Tyr  Phe Ala Pro Ala Asn  Thr His Asn 
    1655                 1660                 1665             


Asn Asn  Ile Glu Gly Gln Ala  Ile Val Tyr Gln Asn  Lys Phe Leu 
    1670                 1675                 1680             


Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Asp Asn Asp  Ser Lys Ala 
    1685                 1690                 1695             


Val Thr  Gly Trp Gln Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn 
    1700                 1705                 1710             


Leu Asn  Thr Ala Glu Ala Ala  Thr Gly Trp Gln Thr  Ile Asp Gly 
    1715                 1720                 1725             


Lys Lys  Tyr Tyr Phe Asn Leu  Asn Thr Ala Glu Ala  Ala Thr Gly 
    1730                 1735                 1740             


Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr 
    1745                 1750                 1755             


Phe Ile  Ala Ser Thr Gly Tyr  Thr Ser Ile Asn Gly  Lys His Phe 
    1760                 1765                 1770             


Tyr Phe  Asn Thr Asp Gly Ile  Met Gln Ile Gly Val  Phe Lys Gly 
    1775                 1780                 1785             


Pro Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  His Asn Asn 
    1790                 1795                 1800             


Asn Ile  Glu Gly Gln Ala Ile  Leu Tyr Gln Asn Lys  Phe Leu Thr 
    1805                 1810                 1815             


Leu Asn  Gly Lys Lys Tyr Tyr  Phe Gly Ser Asp Ser  Lys Ala Val 
    1820                 1825                 1830             


Thr Gly  Leu Arg Thr Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr 
    1835                 1840                 1845             


Asn Thr  Ala Val Ala Val Thr  Gly Trp Gln Thr Ile  Asn Gly Lys 
    1850                 1855                 1860             


Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ser Ile Ala Ser  Thr Gly Tyr 
    1865                 1870                 1875             


Thr Ile  Ile Ser Gly Lys His  Phe Tyr Phe Asn Thr  Asp Gly Ile 
    1880                 1885                 1890             


Met Gln  Ile Gly Val Phe Lys  Gly Pro Asp Gly Phe  Glu Tyr Phe 
    1895                 1900                 1905             


Ala Pro  Ala Asn Thr Asp Ala  Asn Asn Ile Glu Gly  Gln Ala Ile 
    1910                 1915                 1920             


Arg Tyr  Gln Asn Arg Phe Leu  Tyr Leu His Asp Asn  Ile Tyr Tyr 
    1925                 1930                 1935             


Phe Gly  Asn Asn Ser Lys Ala  Ala Thr Gly Trp Val  Thr Ile Asp 
    1940                 1945                 1950             


Gly Asn  Arg Tyr Tyr Phe Glu  Pro Asn Thr Ala Met  Gly Ala Asn 
    1955                 1960                 1965             


Gly Tyr  Lys Thr Ile Asp Asn  Lys Asn Phe Tyr Phe  Arg Asn Gly 
    1970                 1975                 1980             


Leu Pro  Gln Ile Gly Val Phe  Lys Gly Ser Asn Gly  Phe Glu Tyr 
    1985                 1990                 1995             


Phe Ala  Pro Ala Asn Thr Asp  Ala Asn Asn Ile Glu  Gly Gln Ala 
    2000                 2005                 2010             


Ile Arg  Tyr Gln Asn Arg Phe  Leu His Leu Leu Gly  Lys Ile Tyr 
    2015                 2020                 2025             


Tyr Phe  Gly Asn Asn Ser Lys  Ala Val Thr Gly Trp  Gln Thr Ile 
    2030                 2035                 2040             


Asn Gly  Lys Val Tyr Tyr Phe  Met Pro Asp Thr Ala  Met Ala Ala 
    2045                 2050                 2055             


Ala Gly  Gly Leu Phe Glu Ile  Asp Gly Val Ile Tyr  Phe Phe Gly 
    2060                 2065                 2070             


Val Asp  Gly Val Lys Ala Pro  Gly Ile Tyr Gly 
    2075                 2080                 


<210>  21
<211>  1723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  21

His His His His His His Ser His Met Ala Ser Asp Lys Ile Ile His 
1               5                   10                  15      


Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp Gly Ala 
            20                  25                  30          


Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys Met Ile 
        35                  40                  45              


Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys Leu Thr 
    50                  55                  60                  


Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro Lys Tyr 
65                  70                  75                  80  


Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly Glu Val 
                85                  90                  95      


Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys Glu Phe 
            100                 105                 110         


Leu Asp Ala Asn Leu Ala Arg Ala Leu Val Pro Arg Gly Ser Val Thr 
        115                 120                 125             


Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro Phe Thr Met Glu 
    130                 135                 140                 


Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu Val 
145                 150                 155                 160 


Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser 
                165                 170                 175     


Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met Glu Gly Gly Ser Gly 
            180                 185                 190         


His Thr Val Thr Gly Asn Ile Asp His Phe Phe Ser Ser Pro Ser Ile 
        195                 200                 205             


Ser Ser His Ile Pro Ser Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu 
    210                 215                 220                 


Thr Glu Asn Leu Asp Phe Ser Lys Lys Ile Met Met Leu Pro Asn Ala 
225                 230                 235                 240 


Pro Ser Arg Val Phe Trp Trp Glu Thr Gly Ala Val Pro Gly Leu Arg 
                245                 250                 255     


Ser Leu Glu Asn Asp Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu 
            260                 265                 270         


Tyr Pro Gly Lys Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala 
        275                 280                 285             


Ile Thr Thr Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys 
    290                 295                 300                 


Leu Asp Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr 
                325                 330                 335     


Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu 
            340                 345                 350         


Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg Glu 
        355                 360                 365             


Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile Lys Asp 
    370                 375                 380                 


Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn 
385                 390                 395                 400 


Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile 
                405                 410                 415     


Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile 
            420                 425                 430         


Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn 
        435                 440                 445             


Tyr Leu Ile Ser Asn Leu Ser Asn Ile Ile Glu Lys Ile Asn Thr Leu 
    450                 455                 460                 


Gly Leu Asp Ser Lys Asn Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn 
465                 470                 475                 480 


Asn Lys Tyr Phe Gly Ala Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile 
                485                 490                 495     


His Tyr Lys Lys Asp Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser 
            500                 505                 510         


Thr Leu Glu Phe Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val 
        515                 520                 525             


Phe Met Lys Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp 
    530                 535                 540                 


Asn Asn Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys 
545                 550                 555                 560 


Asn Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser 
                565                 570                 575     


Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser 
            580                 585                 590         


Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu Phe 
        595                 600                 605             


Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr Leu Val 
    610                 615                 620                 


Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp Asn Asn Lys 
625                 630                 635                 640 


Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser Ser Ser Lys Ser 
                645                 650                 655     


Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val Val Glu Pro Ile Tyr 
            660                 665                 670         


Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr Ser Leu Asp Phe Ser Tyr 
        675                 680                 685             


Glu Pro Leu Tyr Gly Ile Asp Arg Tyr Ile Asn Lys Val Leu Ile Ala 
    690                 695                 700                 


Pro Asp Leu Tyr Thr Ser Leu Ile Asn Ile Asn Thr Asn Tyr Tyr Ser 
705                 710                 715                 720 


Asn Glu Tyr Tyr Pro Glu Ile Ile Val Leu Asn Pro Asn Thr Phe His 
                725                 730                 735     


Lys Lys Val Asn Ile Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp 
            740                 745                 750         


Ser Thr Glu Gly Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser 
        755                 760                 765             


Asn Lys Lys Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn 
    770                 775                 780                 


Thr Gln Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys 
785                 790                 795                 800 


Leu Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu 
                805                 810                 815     


Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys 
            820                 825                 830         


Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile Asn 
        835                 840                 845             


Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn Leu Val 
    850                 855                 860                 


Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile Asn 
865                 870                 875                 880 


Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile Asn Gly Lys His Phe 
                885                 890                 895     


Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly Val Phe Lys Gly Pro 
            900                 905                 910         


Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Gln Asn Asn Asn Ile 
        915                 920                 925             


Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly 
    930                 935                 940                 


Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Arg 
945                 950                 955                 960 


Ile Ile Asn Asn Glu Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala 
                965                 970                 975     


Ala Val Gly Leu Gln Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro 
            980                 985                 990         


Asp Thr Ala Ile Ile Ser Lys Gly  Trp Gln Thr Val Asn  Gly Ser Arg 
        995                 1000                 1005             


Tyr Tyr  Phe Asp Thr Asp Thr  Ala Ile Ala Phe Asn  Gly Tyr Lys 
    1010                 1015                 1020             


Thr Ile  Asp Gly Lys His Phe  Tyr Phe Asp Ser Asp  Cys Val Val 
    1025                 1030                 1035             


Lys Ile  Gly Val Phe Ser Thr  Ser Asn Gly Phe Glu  Tyr Phe Ala 
    1040                 1045                 1050             


Pro Ala  Asn Thr Tyr Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Val 
    1055                 1060                 1065             


Tyr Gln  Ser Lys Phe Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe 
    1070                 1075                 1080             


Asp Asn  Asn Ser Lys Ala Val  Thr Gly Trp Gln Thr  Ile Asp Ser 
    1085                 1090                 1095             


Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ala Glu Ala  Ala Thr Gly 
    1100                 1105                 1110             


Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr 
    1115                 1120                 1125             


Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr 
    1130                 1135                 1140             


Tyr Phe  Asn Thr Asn Thr Ala  Ile Ala Ser Thr Gly  Tyr Thr Ile 
    1145                 1150                 1155             


Ile Asn  Gly Lys His Phe Tyr  Phe Asn Thr Asp Gly  Ile Met Gln 
    1160                 1165                 1170             


Ile Gly  Val Phe Lys Gly Pro  Asn Gly Phe Glu Tyr  Phe Ala Pro 
    1175                 1180                 1185             


Ala Asn  Thr Asp Ala Asn Asn  Ile Glu Gly Gln Ala  Ile Leu Tyr 
    1190                 1195                 1200             


Gln Asn  Glu Phe Leu Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Gly 
    1205                 1210                 1215             


Ser Asp  Ser Lys Ala Val Thr  Gly Trp Arg Ile Ile  Asn Asn Lys 
    1220                 1225                 1230             


Lys Tyr  Tyr Phe Asn Pro Asn  Asn Ala Ile Ala Ala  Ile His Leu 
    1235                 1240                 1245             


Cys Thr  Ile Asn Asn Asp Lys  Tyr Tyr Phe Ser Tyr  Asp Gly Ile 
    1250                 1255                 1260             


Leu Gln  Asn Gly Tyr Ile Thr  Ile Glu Arg Asn Asn  Phe Tyr Phe 
    1265                 1270                 1275             


Asp Ala  Asn Asn Glu Ser Lys  Met Val Thr Gly Val  Phe Lys Gly 
    1280                 1285                 1290             


Pro Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  His Asn Asn 
    1295                 1300                 1305             


Asn Ile  Glu Gly Gln Ala Ile  Val Tyr Gln Asn Lys  Phe Leu Thr 
    1310                 1315                 1320             


Leu Asn  Gly Lys Lys Tyr Tyr  Phe Asp Asn Asp Ser  Lys Ala Val 
    1325                 1330                 1335             


Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Leu 
    1340                 1345                 1350             


Asn Thr  Ala Glu Ala Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys 
    1355                 1360                 1365             


Lys Tyr  Tyr Phe Asn Leu Asn  Thr Ala Glu Ala Ala  Thr Gly Trp 
    1370                 1375                 1380             


Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Phe 
    1385                 1390                 1395             


Ile Ala  Ser Thr Gly Tyr Thr  Ser Ile Asn Gly Lys  His Phe Tyr 
    1400                 1405                 1410             


Phe Asn  Thr Asp Gly Ile Met  Gln Ile Gly Val Phe  Lys Gly Pro 
    1415                 1420                 1425             


Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn Thr His  Asn Asn Asn 
    1430                 1435                 1440             


Ile Glu  Gly Gln Ala Ile Leu  Tyr Gln Asn Lys Phe  Leu Thr Leu 
    1445                 1450                 1455             


Asn Gly  Lys Lys Tyr Tyr Phe  Gly Ser Asp Ser Lys  Ala Val Thr 
    1460                 1465                 1470             


Gly Leu  Arg Thr Ile Asp Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn 
    1475                 1480                 1485             


Thr Ala  Val Ala Val Thr Gly  Trp Gln Thr Ile Asn  Gly Lys Lys 
    1490                 1495                 1500             


Tyr Tyr  Phe Asn Thr Asn Thr  Ser Ile Ala Ser Thr  Gly Tyr Thr 
    1505                 1510                 1515             


Ile Ile  Ser Gly Lys His Phe  Tyr Phe Asn Thr Asp  Gly Ile Met 
    1520                 1525                 1530             


Gln Ile  Gly Val Phe Lys Gly  Pro Asp Gly Phe Glu  Tyr Phe Ala 
    1535                 1540                 1545             


Pro Ala  Asn Thr Asp Ala Asn  Asn Ile Glu Gly Gln  Ala Ile Arg 
    1550                 1555                 1560             


Tyr Gln  Asn Arg Phe Leu Tyr  Leu His Asp Asn Ile  Tyr Tyr Phe 
    1565                 1570                 1575             


Gly Asn  Asn Ser Lys Ala Ala  Thr Gly Trp Val Thr  Ile Asp Gly 
    1580                 1585                 1590             


Asn Arg  Tyr Tyr Phe Glu Pro  Asn Thr Ala Met Gly  Ala Asn Gly 
    1595                 1600                 1605             


Tyr Lys  Thr Ile Asp Asn Lys  Asn Phe Tyr Phe Arg  Asn Gly Leu 
    1610                 1615                 1620             


Pro Gln  Ile Gly Val Phe Lys  Gly Ser Asn Gly Phe  Glu Tyr Phe 
    1625                 1630                 1635             


Ala Pro  Ala Asn Thr Asp Ala  Asn Asn Ile Glu Gly  Gln Ala Ile 
    1640                 1645                 1650             


Arg Tyr  Gln Asn Arg Phe Leu  His Leu Leu Gly Lys  Ile Tyr Tyr 
    1655                 1660                 1665             


Phe Gly  Asn Asn Ser Lys Ala  Val Thr Gly Trp Gln  Thr Ile Asn 
    1670                 1675                 1680             


Gly Lys  Val Tyr Tyr Phe Met  Pro Asp Thr Ala Met  Ala Ala Ala 
    1685                 1690                 1695             


Gly Gly  Leu Phe Glu Ile Asp  Gly Val Ile Tyr Phe  Phe Gly Val 
    1700                 1705                 1710             


Asp Gly  Val Lys Ala Pro Gly  Ile Tyr Gly 
    1715                 1720             


<210>  22
<211>  2111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  22

His His His His His His Ser His Met Ala Ser Asn Lys Glu Ile Leu 
1               5                   10                  15      


Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu Pro Arg Glu Lys 
            20                  25                  30          


Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala Thr Lys Lys Lys 
        35                  40                  45              


Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp Arg Lys Ser Gly 
    50                  55                  60                  


Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp Glu Val Thr Gln 
65                  70                  75                  80  


Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr Glu Asp Glu Ser 
                85                  90                  95      


Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu Ser Val Thr Phe 
            100                 105                 110         


Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile Val Gln Lys Val 
        115                 120                 125             


Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe Arg Glu His Glu 
    130                 135                 140                 


Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn Arg Asp Asn Ile 
145                 150                 155                 160 


Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile Leu Arg Glu Asp 
                165                 170                 175     


Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg Val Arg Gly Val 
            180                 185                 190         


Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln Leu Phe Val Thr 
        195                 200                 205             


Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg Ile Glu Val Pro 
    210                 215                 220                 


Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala Ala Arg Asp Pro 
225                 230                 235                 240 


Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp Lys Arg Ile Asp 
                245                 250                 255     


Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg Val Gln Ala Val 
            260                 265                 270         


Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val Leu Trp Asp Asp 
        275                 280                 285             


Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro Ala Asp Val Ala 
    290                 295                 300                 


Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp Ile Ala Val Glu 
305                 310                 315                 320 


Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly Gln Asn Val Arg 
                325                 330                 335     


Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val Met Thr Val Asp 
            340                 345                 350         


Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala Ala Ile Asp Thr 
        355                 360                 365             


Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala Thr Val Leu Val 
    370                 375                 380                 


Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr Val Pro Met Lys 
385                 390                 395                 400 


Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr Val Glu Ala Leu 
                405                 410                 415     


Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala Gln Ala Gln Glu 
            420                 425                 430         


Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu Leu Asn Leu Glu 
        435                 440                 445             


Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala Arg Gly Val Cys 
    450                 455                 460                 


Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp Leu Ala Asp Ile 
465                 470                 475                 480 


Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile Met Ala Ala Arg 
                485                 490                 495     


Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala Leu Val Pro Arg 
            500                 505                 510         


Gly Ser Val Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro 
        515                 520                 525             


Phe Thr Met Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp 
    530                 535                 540                 


Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe 
545                 550                 555                 560 


Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met Glu 
                565                 570                 575     


Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe Phe Ser 
            580                 585                 590         


Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile Tyr Ser Ala 
        595                 600                 605             


Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys Lys Ile Met Met 
    610                 615                 620                 


Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp Glu Thr Gly Ala Val 
625                 630                 635                 640 


Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Arg Leu Leu Asp Ser 
                645                 650                 655     


Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr Trp Arg Phe Tyr Ala Phe 
            660                 665                 670         


Phe Asp Tyr Ala Ile Thr Thr Leu Lys Pro Val Tyr Glu Asp Thr Asn 
        675                 680                 685             


Ile Lys Ile Lys Leu Asp Lys Asp Thr Arg Asn Phe Ile Met Pro Thr 
    690                 695                 700                 


Ile Thr Thr Asn Glu Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly 
705                 710                 715                 720 


Ala Gly Gly Thr Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr 
                725                 730                 735     


Asn Ile Asn Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn 
            740                 745                 750         


Glu Val Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys 
        755                 760                 765             


Leu Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu 
    770                 775                 780                 


Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys 
785                 790                 795                 800 


Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser Leu 
                805                 810                 815     


Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu Leu Ser 
            820                 825                 830         


Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Ile Ile Glu Lys 
        835                 840                 845             


Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala Tyr Asn Tyr Thr 
    850                 855                 860                 


Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile Ser Lys Thr Ser Gln 
865                 870                 875                 880 


Lys Ser Ile Ile His Tyr Lys Lys Asp Ser Lys Asn Ile Leu Glu Phe 
                885                 890                 895     


Tyr Asn Asp Ser Thr Leu Glu Phe Asn Ser Lys Asp Phe Ile Ala Glu 
            900                 905                 910         


Asp Ile Asn Val Phe Met Lys Asp Asp Ile Asn Thr Ile Thr Gly Lys 
        915                 920                 925             


Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser 
    930                 935                 940                 


Leu Val Ser Lys Asn Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu 
945                 950                 955                 960 


Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His 
                965                 970                 975     


His Asn Thr Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe 
            980                 985                 990         


Trp Lys Leu Phe Gly Phe Glu Asn  Ile Asn Phe Val Ile  Asp Lys Tyr 
        995                 1000                 1005             


Phe Thr  Leu Val Gly Lys Thr  Asn Leu Gly Tyr Val  Glu Phe Ile 
    1010                 1015                 1020             


Cys Asp  Asn Asn Lys Asn Ile  Asp Ile Tyr Phe Gly  Glu Trp Lys 
    1025                 1030                 1035             


Thr Ser  Ser Ser Lys Ser Thr  Ile Phe Ser Gly Asn  Gly Arg Asn 
    1040                 1045                 1050             


Val Val  Val Glu Pro Ile Tyr  Asn Pro Asp Thr Gly  Glu Asp Ile 
    1055                 1060                 1065             


Ser Thr  Ser Leu Asp Phe Ser  Tyr Glu Pro Leu Tyr  Gly Ile Asp 
    1070                 1075                 1080             


Arg Tyr  Ile Asn Lys Val Leu  Ile Ala Pro Asp Leu  Tyr Thr Ser 
    1085                 1090                 1095             


Leu Ile  Asn Ile Asn Thr Asn  Tyr Tyr Ser Asn Glu  Tyr Tyr Pro 
    1100                 1105                 1110             


Glu Ile  Ile Val Leu Asn Pro  Asn Thr Phe His Lys  Lys Val Asn 
    1115                 1120                 1125             


Ile Asn  Leu Asp Ser Ser Ser  Phe Glu Tyr Lys Trp  Ser Thr Glu 
    1130                 1135                 1140             


Gly Ser  Asp Phe Ile Leu Val  Arg Tyr Leu Glu Glu  Ser Asn Lys 
    1145                 1150                 1155             


Lys Ile  Leu Gln Lys Ile Arg  Ile Lys Gly Ile Leu  Ser Asn Thr 
    1160                 1165                 1170             


Gln Ser  Phe Asn Lys Met Ser  Ile Asp Phe Lys Asp  Ile Lys Lys 
    1175                 1180                 1185             


Leu Ser  Leu Gly Tyr Ile Met  Ser Asn Phe Lys Ser  Phe Asn Ser 
    1190                 1195                 1200             


Glu Asn  Glu Leu Asp Arg Asp  His Leu Gly Phe Lys  Ile Ile Asp 
    1205                 1210                 1215             


Asn Lys  Thr Tyr Tyr Tyr Asp  Glu Asp Ser Lys Leu  Val Lys Gly 
    1220                 1225                 1230             


Leu Ile  Asn Ile Asn Asn Ser  Leu Phe Tyr Phe Asp  Pro Ile Glu 
    1235                 1240                 1245             


Phe Asn  Leu Val Thr Gly Trp  Gln Thr Ile Asn Gly  Lys Lys Tyr 
    1250                 1255                 1260             


Tyr Phe  Asp Ile Asn Thr Gly  Ala Ala Leu Ile Ser  Tyr Lys Ile 
    1265                 1270                 1275             


Ile Asn  Gly Lys His Phe Tyr  Phe Asn Asn Asp Gly  Val Met Gln 
    1280                 1285                 1290             


Leu Gly  Val Phe Lys Gly Pro  Asp Gly Phe Glu Tyr  Phe Ala Pro 
    1295                 1300                 1305             


Ala Asn  Thr Gln Asn Asn Asn  Ile Glu Gly Gln Ala  Ile Val Tyr 
    1310                 1315                 1320             


Gln Ser  Lys Phe Leu Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Asp 
    1325                 1330                 1335             


Asn Asp  Ser Lys Ala Val Thr  Gly Trp Arg Ile Ile  Asn Asn Glu 
    1340                 1345                 1350             


Lys Tyr  Tyr Phe Asn Pro Asn  Asn Ala Ile Ala Ala  Val Gly Leu 
    1355                 1360                 1365             


Gln Val  Ile Asp Asn Asn Lys  Tyr Tyr Phe Asn Pro  Asp Thr Ala 
    1370                 1375                 1380             


Ile Ile  Ser Lys Gly Trp Gln  Thr Val Asn Gly Ser  Arg Tyr Tyr 
    1385                 1390                 1395             


Phe Asp  Thr Asp Thr Ala Ile  Ala Phe Asn Gly Tyr  Lys Thr Ile 
    1400                 1405                 1410             


Asp Gly  Lys His Phe Tyr Phe  Asp Ser Asp Cys Val  Val Lys Ile 
    1415                 1420                 1425             


Gly Val  Phe Ser Thr Ser Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala 
    1430                 1435                 1440             


Asn Thr  Tyr Asn Asn Asn Ile  Glu Gly Gln Ala Ile  Val Tyr Gln 
    1445                 1450                 1455             


Ser Lys  Phe Leu Thr Leu Asn  Gly Lys Lys Tyr Tyr  Phe Asp Asn 
    1460                 1465                 1470             


Asn Ser  Lys Ala Val Thr Gly  Trp Gln Thr Ile Asp  Ser Lys Lys 
    1475                 1480                 1485             


Tyr Tyr  Phe Asn Thr Asn Thr  Ala Glu Ala Ala Thr  Gly Trp Gln 
    1490                 1495                 1500             


Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Glu 
    1505                 1510                 1515             


Ala Ala  Thr Gly Trp Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe 
    1520                 1525                 1530             


Asn Thr  Asn Thr Ala Ile Ala  Ser Thr Gly Tyr Thr  Ile Ile Asn 
    1535                 1540                 1545             


Gly Lys  His Phe Tyr Phe Asn  Thr Asp Gly Ile Met  Gln Ile Gly 
    1550                 1555                 1560             


Val Phe  Lys Gly Pro Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn 
    1565                 1570                 1575             


Thr Asp  Ala Asn Asn Ile Glu  Gly Gln Ala Ile Leu  Tyr Gln Asn 
    1580                 1585                 1590             


Glu Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr Tyr Phe  Gly Ser Asp 
    1595                 1600                 1605             


Ser Lys  Ala Val Thr Gly Trp  Arg Ile Ile Asn Asn  Lys Lys Tyr 
    1610                 1615                 1620             


Tyr Phe  Asn Pro Asn Asn Ala  Ile Ala Ala Ile His  Leu Cys Thr 
    1625                 1630                 1635             


Ile Asn  Asn Asp Lys Tyr Tyr  Phe Ser Tyr Asp Gly  Ile Leu Gln 
    1640                 1645                 1650             


Asn Gly  Tyr Ile Thr Ile Glu  Arg Asn Asn Phe Tyr  Phe Asp Ala 
    1655                 1660                 1665             


Asn Asn  Glu Ser Lys Met Val  Thr Gly Val Phe Lys  Gly Pro Asn 
    1670                 1675                 1680             


Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr His Asn  Asn Asn Ile 
    1685                 1690                 1695             


Glu Gly  Gln Ala Ile Val Tyr  Gln Asn Lys Phe Leu  Thr Leu Asn 
    1700                 1705                 1710             


Gly Lys  Lys Tyr Tyr Phe Asp  Asn Asp Ser Lys Ala  Val Thr Gly 
    1715                 1720                 1725             


Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr Phe Asn  Leu Asn Thr 
    1730                 1735                 1740             


Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr 
    1745                 1750                 1755             


Tyr Phe  Asn Leu Asn Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr 
    1760                 1765                 1770             


Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr Asn Thr  Phe Ile Ala 
    1775                 1780                 1785             


Ser Thr  Gly Tyr Thr Ser Ile  Asn Gly Lys His Phe  Tyr Phe Asn 
    1790                 1795                 1800             


Thr Asp  Gly Ile Met Gln Ile  Gly Val Phe Lys Gly  Pro Asn Gly 
    1805                 1810                 1815             


Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr His Asn Asn  Asn Ile Glu 
    1820                 1825                 1830             


Gly Gln  Ala Ile Leu Tyr Gln  Asn Lys Phe Leu Thr  Leu Asn Gly 
    1835                 1840                 1845             


Lys Lys  Tyr Tyr Phe Gly Ser  Asp Ser Lys Ala Val  Thr Gly Leu 
    1850                 1855                 1860             


Arg Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ala 
    1865                 1870                 1875             


Val Ala  Val Thr Gly Trp Gln  Thr Ile Asn Gly Lys  Lys Tyr Tyr 
    1880                 1885                 1890             


Phe Asn  Thr Asn Thr Ser Ile  Ala Ser Thr Gly Tyr  Thr Ile Ile 
    1895                 1900                 1905             


Ser Gly  Lys His Phe Tyr Phe  Asn Thr Asp Gly Ile  Met Gln Ile 
    1910                 1915                 1920             


Gly Val  Phe Lys Gly Pro Asp  Gly Phe Glu Tyr Phe  Ala Pro Ala 
    1925                 1930                 1935             


Asn Thr  Asp Ala Asn Asn Ile  Glu Gly Gln Ala Ile  Arg Tyr Gln 
    1940                 1945                 1950             


Asn Arg  Phe Leu Tyr Leu His  Asp Asn Ile Tyr Tyr  Phe Gly Asn 
    1955                 1960                 1965             


Asn Ser  Lys Ala Ala Thr Gly  Trp Val Thr Ile Asp  Gly Asn Arg 
    1970                 1975                 1980             


Tyr Tyr  Phe Glu Pro Asn Thr  Ala Met Gly Ala Asn  Gly Tyr Lys 
    1985                 1990                 1995             


Thr Ile  Asp Asn Lys Asn Phe  Tyr Phe Arg Asn Gly  Leu Pro Gln 
    2000                 2005                 2010             


Ile Gly  Val Phe Lys Gly Ser  Asn Gly Phe Glu Tyr  Phe Ala Pro 
    2015                 2020                 2025             


Ala Asn  Thr Asp Ala Asn Asn  Ile Glu Gly Gln Ala  Ile Arg Tyr 
    2030                 2035                 2040             


Gln Asn  Arg Phe Leu His Leu  Leu Gly Lys Ile Tyr  Tyr Phe Gly 
    2045                 2050                 2055             


Asn Asn  Ser Lys Ala Val Thr  Gly Trp Gln Thr Ile  Asn Gly Lys 
    2060                 2065                 2070             


Val Tyr  Tyr Phe Met Pro Asp  Thr Ala Met Ala Ala  Ala Gly Gly 
    2075                 2080                 2085             


Leu Phe  Glu Ile Asp Gly Val  Ile Tyr Phe Phe Gly  Val Asp Gly 
    2090                 2095                 2100             


Val Lys  Ala Pro Gly Ile Tyr  Gly 
    2105                 2110     


<210>  23
<211>  2138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  23

His His His His His His Ser His Met Ala Ser Asn Lys Glu Ile Leu 
1               5                   10                  15      


Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu Pro Arg Glu Lys 
            20                  25                  30          


Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala Thr Lys Lys Lys 
        35                  40                  45              


Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp Arg Lys Ser Gly 
    50                  55                  60                  


Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp Glu Val Thr Gln 
65                  70                  75                  80  


Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr Glu Asp Glu Ser 
                85                  90                  95      


Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu Ser Val Thr Phe 
            100                 105                 110         


Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile Val Gln Lys Val 
        115                 120                 125             


Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe Arg Glu His Glu 
    130                 135                 140                 


Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn Arg Asp Asn Ile 
145                 150                 155                 160 


Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile Leu Arg Glu Asp 
                165                 170                 175     


Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg Val Arg Gly Val 
            180                 185                 190         


Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln Leu Phe Val Thr 
        195                 200                 205             


Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg Ile Glu Val Pro 
    210                 215                 220                 


Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala Ala Arg Asp Pro 
225                 230                 235                 240 


Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp Lys Arg Ile Asp 
                245                 250                 255     


Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg Val Gln Ala Val 
            260                 265                 270         


Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val Leu Trp Asp Asp 
        275                 280                 285             


Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro Ala Asp Val Ala 
    290                 295                 300                 


Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp Ile Ala Val Glu 
305                 310                 315                 320 


Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly Gln Asn Val Arg 
                325                 330                 335     


Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val Met Thr Val Asp 
            340                 345                 350         


Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala Ala Ile Asp Thr 
        355                 360                 365             


Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala Thr Val Leu Val 
    370                 375                 380                 


Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr Val Pro Met Lys 
385                 390                 395                 400 


Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr Val Glu Ala Leu 
                405                 410                 415     


Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala Gln Ala Gln Glu 
            420                 425                 430         


Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu Leu Asn Leu Glu 
        435                 440                 445             


Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala Arg Gly Val Cys 
    450                 455                 460                 


Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp Leu Ala Asp Ile 
465                 470                 475                 480 


Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile Met Ala Ala Arg 
                485                 490                 495     


Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala Leu Val Pro Arg 
            500                 505                 510         


Gly Ser Val Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro 
        515                 520                 525             


Phe Thr Met Ser Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser 
    530                 535                 540                 


Phe Asn Pro Lys Glu Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro 
545                 550                 555                 560 


Glu Leu Ser Thr Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser 
                565                 570                 575     


Asp Ile Glu Leu Glu Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn 
            580                 585                 590         


Val Ile Ser Asn Ile Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu 
        595                 600                 605             


Ala Lys Asn Leu Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe 
    610                 615                 620                 


Lys Leu Ile Glu Ser Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln 
625                 630                 635                 640 


Asn Glu Leu Glu Asp Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu 
                645                 650                 655     


Thr Asp Glu Gly Phe Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu 
            660                 665                 670         


Ser Ile Phe Val Glu Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn 
        675                 680                 685             


His Ile Thr Glu Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr 
    690                 695                 700                 


Val Asn Gly Lys Leu Val Lys Lys Val Asn Leu Asp Thr Thr His Glu 
705                 710                 715                 720 


Val Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr 
                725                 730                 735     


Asn Ser Ser Lys Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val 
            740                 745                 750         


Gln Val Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp 
        755                 760                 765             


Ala Ala Lys Val Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile 
    770                 775                 780                 


Asp Leu Leu Pro Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile 
785                 790                 795                 800 


Ile Asp Gly Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr 
                805                 810                 815     


Ser Asp Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met 
            820                 825                 830         


Ala Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu 
        835                 840                 845             


Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile 
    850                 855                 860                 


Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg Asp 
865                 870                 875                 880 


Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu Val Glu 
                885                 890                 895     


Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met Met Pro Gln 
            900                 905                 910         


Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Val 
        915                 920                 925             


Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly Gly Ser Gly His Thr 
    930                 935                 940                 


Val Thr Asp Asp Ile Asp His Phe Phe Ser Ala Pro Ser Ile Thr Tyr 
945                 950                 955                 960 


Arg Glu Pro His Leu Ser Ile Tyr Asp Val Leu Glu Val Gln Lys Glu 
                965                 970                 975     


Glu Leu Asp Leu Ser Lys Asp Leu Met Val Leu Pro Asn Ala Pro Asn 
            980                 985                 990         


Arg Val Phe Ala Trp Glu Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu 
        995                 1000                 1005             


Glu Asn  Asp Gly Thr Lys Leu  Leu Asp Arg Ile Arg  Asp Asn Tyr 
    1010                 1015                 1020             


Glu Gly  Glu Phe Tyr Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala 
    1025                 1030                 1035             


Leu Ile  Thr Thr Leu Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg 
    1040                 1045                 1050             


Ile Asn  Leu Asp Ser Asn Thr  Arg Ser Phe Ile Val  Pro Ile Ile 
    1055                 1060                 1065             


Thr Thr  Glu Tyr Ile Arg Glu  Lys Leu Ser Tyr Ser  Phe Tyr Gly 
    1070                 1075                 1080             


Ser Gly  Gly Thr Tyr Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Gly 
    1085                 1090                 1095             


Ile Asn  Ile Glu Leu Ser Glu  Ser Asp Val Trp Ile  Ile Asp Val 
    1100                 1105                 1110             


Asp Asn  Val Val Arg Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys 
    1115                 1120                 1125             


Lys Gly  Asp Leu Ile Glu Gly  Ile Leu Ser Thr Leu  Ser Ile Glu 
    1130                 1135                 1140             


Glu Asn  Lys Ile Ile Leu Asn  Ser His Glu Ile Asn  Phe Ser Gly 
    1145                 1150                 1155             


Glu Val  Asn Gly Ser Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile 
    1160                 1165                 1170             


Leu Glu  Gly Ile Asn Ala Ile  Ile Glu Val Asp Leu  Leu Ser Lys 
    1175                 1180                 1185             


Ser Tyr  Lys Leu Leu Ile Ser  Gly Glu Leu Lys Ile  Leu Met Leu 
    1190                 1195                 1200             


Asn Ser  Asn His Ile Gln Gln  Lys Ile Asp Tyr Ile  Gly Phe Asn 
    1205                 1210                 1215             


Ser Glu  Leu Gln Lys Asn Ile  Pro Tyr Ser Phe Val  Asp Ser Glu 
    1220                 1225                 1230             


Gly Lys  Glu Asn Gly Phe Ile  Asn Gly Ser Thr Lys  Glu Gly Leu 
    1235                 1240                 1245             


Phe Val  Ser Glu Leu Pro Asp  Val Val Leu Ile Ser  Lys Val Tyr 
    1250                 1255                 1260             


Met Asp  Asp Ser Lys Pro Ser  Phe Gly Tyr Tyr Ser  Asn Asn Leu 
    1265                 1270                 1275             


Lys Asp  Val Lys Val Ile Thr  Lys Asp Asn Val Asn  Ile Leu Thr 
    1280                 1285                 1290             


Gly Tyr  Tyr Leu Lys Asp Asp  Ile Lys Ile Ser Leu  Ser Leu Thr 
    1295                 1300                 1305             


Leu Gln  Asp Glu Lys Thr Ile  Lys Leu Asn Ser Val  His Leu Asp 
    1310                 1315                 1320             


Glu Ser  Gly Val Ala Glu Ile  Leu Lys Phe Met Asn  Arg Lys Gly 
    1325                 1330                 1335             


Asn Thr  Asn Thr Ser Asp Ser  Leu Met Ser Phe Leu  Glu Ser Met 
    1340                 1345                 1350             


Asn Ile  Lys Ser Ile Phe Val  Asn Phe Leu Gln Ser  Asn Ile Lys 
    1355                 1360                 1365             


Phe Ile  Leu Asp Ala Asn Phe  Ile Ile Ser Gly Thr  Thr Ser Ile 
    1370                 1375                 1380             


Gly Gln  Phe Glu Phe Ile Cys  Asp Glu Asn Asp Asn  Ile Gln Pro 
    1385                 1390                 1395             


Tyr Phe  Ile Lys Phe Asn Thr  Leu Glu Thr Asn Tyr  Thr Leu Tyr 
    1400                 1405                 1410             


Val Gly  Asn Arg Gln Asn Met  Ile Val Glu Pro Asn  Tyr Asp Leu 
    1415                 1420                 1425             


Asp Asp  Ser Gly Asp Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln 
    1430                 1435                 1440             


Lys Tyr  Leu Tyr Gly Ile Asp  Ser Cys Val Asn Lys  Val Val Ile 
    1445                 1450                 1455             


Ser Pro  Asn Ile Tyr Thr Asp  Glu Ile Asn Ile Thr  Pro Val Tyr 
    1460                 1465                 1470             


Glu Thr  Asn Asn Thr Tyr Pro  Glu Val Ile Val Leu  Asp Ala Asn 
    1475                 1480                 1485             


Tyr Ile  Asn Glu Lys Ile Asn  Val Asn Ile Asn Asp  Leu Ser Ile 
    1490                 1495                 1500             


Arg Tyr  Val Trp Ser Asn Asp  Gly Asn Asp Phe Ile  Leu Met Ser 
    1505                 1510                 1515             


Thr Ser  Glu Glu Asn Lys Val  Ser Gln Val Lys Ile  Arg Phe Val 
    1520                 1525                 1530             


Asn Val  Phe Lys Asp Lys Thr  Leu Ala Asn Lys Leu  Ser Phe Asn 
    1535                 1540                 1545             


Phe Ser  Asp Lys Gln Asp Val  Pro Val Ser Glu Ile  Ile Leu Ser 
    1550                 1555                 1560             


Phe Thr  Pro Ser Tyr Tyr Glu  Asp Gly Leu Ile Gly  Tyr Asp Leu 
    1565                 1570                 1575             


Gly Leu  Val Ser Leu Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe 
    1580                 1585                 1590             


Gly Met  Met Val Ser Gly Leu  Ile Tyr Ile Asn Asp  Ser Leu Tyr 
    1595                 1600                 1605             


Tyr Phe  Lys Pro Pro Val Asn  Asn Leu Ile Thr Gly  Phe Val Thr 
    1610                 1615                 1620             


Val Gly  Asp Asp Lys Tyr Tyr  Phe Asn Pro Ile Asn  Gly Gly Ala 
    1625                 1630                 1635             


Ala Ser  Ile Gly Glu Thr Ile  Ile Asp Asp Lys Asn  Tyr Tyr Phe 
    1640                 1645                 1650             


Asn Gln  Ser Gly Val Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp 
    1655                 1660                 1665             


Gly Phe  Lys Tyr Phe Ala Pro  Ala Asn Thr Leu Asp  Glu Asn Leu 
    1670                 1675                 1680             


Glu Gly  Glu Ala Ile Asp Phe  Thr Gly Lys Leu Ile  Ile Asp Glu 
    1685                 1690                 1695             


Asn Ile  Tyr Tyr Phe Asp Asp  Asn Tyr Arg Gly Ala  Val Glu Trp 
    1700                 1705                 1710             


Lys Glu  Leu Asp Gly Glu Met  His Tyr Phe Ser Pro  Glu Thr Gly 
    1715                 1720                 1725             


Lys Ala  Phe Lys Gly Leu Asn  Gln Ile Gly Asp Tyr  Lys Tyr Tyr 
    1730                 1735                 1740             


Phe Asn  Ser Asp Gly Val Met  Gln Lys Gly Phe Val  Ser Ile Asn 
    1745                 1750                 1755             


Asp Asn  Lys His Tyr Phe Asp  Asp Ser Gly Val Met  Lys Val Gly 
    1760                 1765                 1770             


Tyr Thr  Glu Ile Asp Gly Lys  His Phe Tyr Phe Ala  Glu Asn Gly 
    1775                 1780                 1785             


Glu Met  Gln Ile Gly Val Phe  Asn Thr Glu Asp Gly  Phe Lys Tyr 
    1790                 1795                 1800             


Phe Ala  His His Asn Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Glu 
    1805                 1810                 1815             


Ile Ser  Tyr Ser Gly Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr 
    1820                 1825                 1830             


Phe Asp  Asp Ser Phe Thr Ala  Val Val Gly Trp Lys  Asp Leu Glu 
    1835                 1840                 1845             


Asp Gly  Ser Lys Tyr Tyr Phe  Asp Glu Asp Thr Ala  Glu Ala Tyr 
    1850                 1855                 1860             


Ile Gly  Leu Ser Leu Ile Asn  Asp Gly Gln Tyr Tyr  Phe Asn Asp 
    1865                 1870                 1875             


Asp Gly  Ile Met Gln Val Gly  Phe Val Thr Ile Asn  Asp Lys Val 
    1880                 1885                 1890             


Phe Tyr  Phe Ser Asp Ser Gly  Ile Ile Glu Ser Gly  Val Gln Asn 
    1895                 1900                 1905             


Ile Asp  Asp Asn Tyr Phe Tyr  Ile Asp Asp Asn Gly  Ile Val Gln 
    1910                 1915                 1920             


Ile Gly  Val Phe Asp Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro 
    1925                 1930                 1935             


Ala Asn  Thr Val Asn Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr 
    1940                 1945                 1950             


Ser Gly  Leu Val Arg Val Gly  Glu Asp Val Tyr Tyr  Phe Gly Glu 
    1955                 1960                 1965             


Thr Tyr  Thr Ile Glu Thr Gly  Trp Ile Tyr Asp Met  Glu Asn Glu 
    1970                 1975                 1980             


Ser Asp  Lys Tyr Tyr Phe Asn  Pro Glu Thr Lys Lys  Ala Cys Lys 
    1985                 1990                 1995             


Gly Ile  Asn Leu Ile Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Lys 
    2000                 2005                 2010             


Gly Ile  Met Arg Thr Gly Leu  Ile Ser Phe Glu Asn  Asn Asn Tyr 
    2015                 2020                 2025             


Tyr Phe  Asn Glu Asn Gly Glu  Met Gln Phe Gly Tyr  Ile Asn Ile 
    2030                 2035                 2040             


Glu Asp  Lys Met Phe Tyr Phe  Gly Glu Asp Gly Val  Met Gln Ile 
    2045                 2050                 2055             


Gly Val  Phe Asn Thr Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln 
    2060                 2065                 2070             


Asn Thr  Leu Asp Glu Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr 
    2075                 2080                 2085             


Gly Trp  Leu Asp Leu Asp Glu  Lys Arg Tyr Tyr Phe  Thr Asp Glu 
    2090                 2095                 2100             


Tyr Ile  Ala Ala Thr Gly Ser  Val Ile Ile Asp Gly  Glu Glu Tyr 
    2105                 2110                 2115             


Tyr Phe  Asp Pro Asp Thr Ala  Gln Leu Val Ile Ser  Glu Gly His 
    2120                 2125                 2130             


His His  His His His 
    2135             


<210>  24
<211>  2131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  24

His His His His His His Ser His Met Ala Ser Asn Lys Glu Ile Leu 
1               5                   10                  15      


Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu Pro Arg Glu Lys 
            20                  25                  30          


Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala Thr Lys Lys Lys 
        35                  40                  45              


Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp Arg Lys Ser Gly 
    50                  55                  60                  


Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp Glu Val Thr Gln 
65                  70                  75                  80  


Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr Glu Asp Glu Ser 
                85                  90                  95      


Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu Ser Val Thr Phe 
            100                 105                 110         


Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile Val Gln Lys Val 
        115                 120                 125             


Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe Arg Glu His Glu 
    130                 135                 140                 


Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn Arg Asp Asn Ile 
145                 150                 155                 160 


Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile Leu Arg Glu Asp 
                165                 170                 175     


Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg Val Arg Gly Val 
            180                 185                 190         


Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln Leu Phe Val Thr 
        195                 200                 205             


Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg Ile Glu Val Pro 
    210                 215                 220                 


Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala Ala Arg Asp Pro 
225                 230                 235                 240 


Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp Lys Arg Ile Asp 
                245                 250                 255     


Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg Val Gln Ala Val 
            260                 265                 270         


Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val Leu Trp Asp Asp 
        275                 280                 285             


Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro Ala Asp Val Ala 
    290                 295                 300                 


Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp Ile Ala Val Glu 
305                 310                 315                 320 


Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly Gln Asn Val Arg 
                325                 330                 335     


Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val Met Thr Val Asp 
            340                 345                 350         


Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala Ala Ile Asp Thr 
        355                 360                 365             


Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala Thr Val Leu Val 
    370                 375                 380                 


Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr Val Pro Met Lys 
385                 390                 395                 400 


Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr Val Glu Ala Leu 
                405                 410                 415     


Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala Gln Ala Gln Glu 
            420                 425                 430         


Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu Leu Asn Leu Glu 
        435                 440                 445             


Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala Arg Gly Val Cys 
    450                 455                 460                 


Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp Leu Ala Asp Ile 
465                 470                 475                 480 


Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile Met Ala Ala Arg 
                485                 490                 495     


Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala Leu Val Pro Arg 
            500                 505                 510         


Gly Ser Val Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro 
        515                 520                 525             


Phe Thr Met Ser Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser 
    530                 535                 540                 


Phe Asn Pro Lys Glu Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro 
545                 550                 555                 560 


Glu Leu Ser Thr Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser 
                565                 570                 575     


Asp Ile Glu Leu Glu Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn 
            580                 585                 590         


Val Ile Ser Asn Ile Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu 
        595                 600                 605             


Ala Lys Asn Leu Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe 
    610                 615                 620                 


Lys Leu Ile Glu Ser Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln 
625                 630                 635                 640 


Asn Glu Leu Glu Asp Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu 
                645                 650                 655     


Thr Asp Glu Gly Phe Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu 
            660                 665                 670         


Ser Ile Phe Val Glu Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn 
        675                 680                 685             


His Ile Thr Glu Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr 
    690                 695                 700                 


Val Asn Gly Lys Leu Val Lys Lys Val Asn Leu Asp Thr Thr His Glu 
705                 710                 715                 720 


Val Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr 
                725                 730                 735     


Asn Ser Ser Lys Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val 
            740                 745                 750         


Gln Val Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp 
        755                 760                 765             


Ala Ala Lys Val Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile 
    770                 775                 780                 


Asp Leu Leu Pro Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile 
785                 790                 795                 800 


Ile Asp Gly Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr 
                805                 810                 815     


Ser Asp Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met 
            820                 825                 830         


Ala Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu 
        835                 840                 845             


Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile 
    850                 855                 860                 


Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg Asp 
865                 870                 875                 880 


Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu Val Glu 
                885                 890                 895     


Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met Met Pro Gln 
            900                 905                 910         


Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Val 
        915                 920                 925             


Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly Gly Ser Gly His Thr 
    930                 935                 940                 


Val Thr Asp Asp Ile Asp His Phe Phe Ser Ala Pro Ser Ile Thr Tyr 
945                 950                 955                 960 


Arg Glu Pro His Leu Ser Ile Tyr Asp Val Leu Glu Val Gln Lys Glu 
                965                 970                 975     


Glu Leu Asp Leu Ser Lys Asp Leu Met Val Leu Pro Asn Ala Pro Asn 
            980                 985                 990         


Arg Val Phe Ala Trp Glu Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu 
        995                 1000                 1005             


Glu Asn  Asp Gly Thr Lys Leu  Leu Asp Arg Ile Arg  Asp Asn Tyr 
    1010                 1015                 1020             


Glu Gly  Glu Phe Tyr Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala 
    1025                 1030                 1035             


Leu Ile  Thr Thr Leu Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg 
    1040                 1045                 1050             


Ile Asn  Leu Asp Ser Asn Thr  Arg Ser Phe Ile Val  Pro Ile Ile 
    1055                 1060                 1065             


Thr Thr  Glu Tyr Ile Arg Glu  Lys Leu Ser Tyr Ser  Phe Tyr Gly 
    1070                 1075                 1080             


Ser Gly  Gly Thr Tyr Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Gly 
    1085                 1090                 1095             


Ile Asn  Ile Glu Leu Ser Glu  Ser Asp Val Trp Ile  Ile Asp Val 
    1100                 1105                 1110             


Asp Asn  Val Val Arg Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys 
    1115                 1120                 1125             


Lys Gly  Asp Leu Ile Glu Gly  Ile Leu Ser Thr Leu  Ser Ile Glu 
    1130                 1135                 1140             


Glu Asn  Lys Ile Ile Leu Asn  Ser His Glu Ile Asn  Phe Ser Gly 
    1145                 1150                 1155             


Glu Val  Asn Gly Ser Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile 
    1160                 1165                 1170             


Leu Glu  Gly Ile Asn Ala Ile  Ile Glu Val Asp Leu  Leu Ser Lys 
    1175                 1180                 1185             


Ser Tyr  Lys Leu Leu Ile Ser  Gly Glu Leu Lys Ile  Leu Met Leu 
    1190                 1195                 1200             


Asn Ser  Asn His Ile Gln Gln  Lys Ile Asp Tyr Ile  Gly Phe Asn 
    1205                 1210                 1215             


Ser Glu  Leu Gln Lys Asn Ile  Pro Tyr Ser Phe Val  Asp Ser Glu 
    1220                 1225                 1230             


Gly Lys  Glu Asn Gly Phe Ile  Asn Gly Ser Thr Lys  Glu Gly Leu 
    1235                 1240                 1245             


Phe Val  Ser Glu Leu Pro Asp  Val Val Leu Ile Ser  Lys Val Tyr 
    1250                 1255                 1260             


Met Asp  Asp Ser Lys Pro Ser  Phe Gly Tyr Tyr Ser  Asn Asn Leu 
    1265                 1270                 1275             


Lys Asp  Val Lys Val Ile Thr  Lys Asp Asn Val Asn  Ile Leu Thr 
    1280                 1285                 1290             


Gly Tyr  Tyr Leu Lys Asp Asp  Ile Lys Ile Ser Leu  Ser Leu Thr 
    1295                 1300                 1305             


Leu Gln  Asp Glu Lys Thr Ile  Lys Leu Asn Ser Val  His Leu Asp 
    1310                 1315                 1320             


Glu Ser  Gly Val Ala Glu Ile  Leu Lys Phe Met Asn  Arg Lys Gly 
    1325                 1330                 1335             


Asn Thr  Asn Thr Ser Asp Ser  Leu Met Ser Phe Leu  Glu Ser Met 
    1340                 1345                 1350             


Asn Ile  Lys Ser Ile Phe Val  Asn Phe Leu Gln Ser  Asn Ile Lys 
    1355                 1360                 1365             


Phe Ile  Leu Asp Ala Asn Phe  Ile Ile Ser Gly Thr  Thr Ser Ile 
    1370                 1375                 1380             


Gly Gln  Phe Glu Phe Ile Cys  Asp Glu Asn Asp Asn  Ile Gln Pro 
    1385                 1390                 1395             


Tyr Phe  Ile Lys Phe Asn Thr  Leu Glu Thr Asn Tyr  Thr Leu Tyr 
    1400                 1405                 1410             


Val Gly  Asn Arg Gln Asn Met  Ile Val Glu Pro Asn  Tyr Asp Leu 
    1415                 1420                 1425             


Asp Asp  Ser Gly Asp Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln 
    1430                 1435                 1440             


Lys Tyr  Leu Tyr Gly Ile Asp  Ser Cys Val Asn Lys  Val Val Ile 
    1445                 1450                 1455             


Ser Pro  Asn Ile Tyr Thr Asp  Glu Ile Asn Ile Thr  Pro Val Tyr 
    1460                 1465                 1470             


Glu Thr  Asn Asn Thr Tyr Pro  Glu Val Ile Val Leu  Asp Ala Asn 
    1475                 1480                 1485             


Tyr Ile  Asn Glu Lys Ile Asn  Val Asn Ile Asn Asp  Leu Ser Ile 
    1490                 1495                 1500             


Arg Tyr  Val Trp Ser Asn Asp  Gly Asn Asp Phe Ile  Leu Met Ser 
    1505                 1510                 1515             


Thr Ser  Glu Glu Asn Lys Val  Ser Gln Val Lys Ile  Arg Phe Val 
    1520                 1525                 1530             


Asn Val  Phe Lys Asp Lys Thr  Leu Ala Asn Lys Leu  Ser Phe Asn 
    1535                 1540                 1545             


Phe Ser  Asp Lys Gln Asp Val  Pro Val Ser Glu Ile  Ile Leu Ser 
    1550                 1555                 1560             


Phe Thr  Pro Ser Tyr Tyr Glu  Asp Gly Leu Ile Gly  Tyr Asp Leu 
    1565                 1570                 1575             


Gly Leu  Val Ser Leu Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe 
    1580                 1585                 1590             


Gly Met  Met Val Ser Gly Leu  Ile Tyr Ile Asn Asp  Ser Leu Tyr 
    1595                 1600                 1605             


Tyr Phe  Lys Pro Pro Val Asn  Asn Leu Ile Thr Gly  Phe Val Thr 
    1610                 1615                 1620             


Val Gly  Asp Asp Lys Tyr Tyr  Phe Asn Pro Ile Asn  Gly Gly Ala 
    1625                 1630                 1635             


Ala Ser  Ile Gly Glu Thr Ile  Ile Asp Asp Lys Asn  Tyr Tyr Phe 
    1640                 1645                 1650             


Asn Gln  Ser Gly Val Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp 
    1655                 1660                 1665             


Gly Phe  Lys Tyr Phe Ala Pro  Ala Asn Thr Leu Asp  Glu Asn Leu 
    1670                 1675                 1680             


Glu Gly  Glu Ala Ile Asp Phe  Thr Gly Lys Leu Ile  Ile Asp Glu 
    1685                 1690                 1695             


Asn Ile  Tyr Tyr Phe Asp Asp  Asn Tyr Arg Gly Ala  Val Glu Trp 
    1700                 1705                 1710             


Lys Glu  Leu Asp Gly Glu Met  His Tyr Phe Ser Pro  Glu Thr Gly 
    1715                 1720                 1725             


Lys Ala  Phe Lys Gly Leu Asn  Gln Ile Gly Asp Tyr  Lys Tyr Tyr 
    1730                 1735                 1740             


Phe Asn  Ser Asp Gly Val Met  Gln Lys Gly Phe Val  Ser Ile Asn 
    1745                 1750                 1755             


Asp Asn  Lys His Tyr Phe Asp  Asp Ser Gly Val Met  Lys Val Gly 
    1760                 1765                 1770             


Tyr Thr  Glu Ile Asp Gly Lys  His Phe Tyr Phe Ala  Glu Asn Gly 
    1775                 1780                 1785             


Glu Met  Gln Ile Gly Val Phe  Asn Thr Glu Asp Gly  Phe Lys Tyr 
    1790                 1795                 1800             


Phe Ala  His His Asn Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Glu 
    1805                 1810                 1815             


Ile Ser  Tyr Ser Gly Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr 
    1820                 1825                 1830             


Phe Asp  Asp Ser Phe Thr Ala  Val Val Gly Trp Lys  Asp Leu Glu 
    1835                 1840                 1845             


Asp Gly  Ser Lys Tyr Tyr Phe  Asp Glu Asp Thr Ala  Glu Ala Tyr 
    1850                 1855                 1860             


Ile Gly  Leu Ser Leu Ile Asn  Asp Gly Gln Tyr Tyr  Phe Asn Asp 
    1865                 1870                 1875             


Asp Gly  Ile Met Gln Val Gly  Phe Val Thr Ile Asn  Asp Lys Val 
    1880                 1885                 1890             


Phe Tyr  Phe Ser Asp Ser Gly  Ile Ile Glu Ser Gly  Val Gln Asn 
    1895                 1900                 1905             


Ile Asp  Asp Asn Tyr Phe Tyr  Ile Asp Asp Asn Gly  Ile Val Gln 
    1910                 1915                 1920             


Ile Gly  Val Phe Asp Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro 
    1925                 1930                 1935             


Ala Asn  Thr Val Asn Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr 
    1940                 1945                 1950             


Ser Gly  Leu Val Arg Val Gly  Glu Asp Val Tyr Tyr  Phe Gly Glu 
    1955                 1960                 1965             


Thr Tyr  Thr Ile Glu Thr Gly  Trp Ile Tyr Asp Met  Glu Asn Glu 
    1970                 1975                 1980             


Ser Asp  Lys Tyr Tyr Phe Asn  Pro Glu Thr Lys Lys  Ala Cys Lys 
    1985                 1990                 1995             


Gly Ile  Asn Leu Ile Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Lys 
    2000                 2005                 2010             


Gly Ile  Met Arg Thr Gly Leu  Ile Ser Phe Glu Asn  Asn Asn Tyr 
    2015                 2020                 2025             


Tyr Phe  Asn Glu Asn Gly Glu  Met Gln Phe Gly Tyr  Ile Asn Ile 
    2030                 2035                 2040             


Glu Asp  Lys Met Phe Tyr Phe  Gly Glu Asp Gly Val  Met Gln Ile 
    2045                 2050                 2055             


Gly Val  Phe Asn Thr Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln 
    2060                 2065                 2070             


Asn Thr  Leu Asp Glu Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr 
    2075                 2080                 2085             


Gly Trp  Leu Asp Leu Asp Glu  Lys Arg Tyr Tyr Phe  Thr Asp Glu 
    2090                 2095                 2100             


Tyr Ile  Ala Ala Thr Gly Ser  Val Ile Ile Asp Gly  Glu Glu Tyr 
    2105                 2110                 2115             


Tyr Phe  Asp Pro Asp Thr Ala  Gln Leu Val Ile Ser  Glu 
    2120                 2125                 2130     


<210>  25
<211>  1743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  25

His His His His His His Ser His Met Ala Ser Asp Lys Ile Ile His 
1               5                   10                  15      


Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp Gly Ala 
            20                  25                  30          


Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys Met Ile 
        35                  40                  45              


Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys Leu Thr 
    50                  55                  60                  


Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro Lys Tyr 
65                  70                  75                  80  


Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly Glu Val 
                85                  90                  95      


Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys Glu Phe 
            100                 105                 110         


Leu Asp Ala Asn Leu Ala Arg Ala Leu Val Pro Arg Gly Ser Val Thr 
        115                 120                 125             


Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro Phe Thr Met Ser 
    130                 135                 140                 


Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys 
145                 150                 155                 160 


Glu Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr 
                165                 170                 175     


Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu 
            180                 185                 190         


Glu Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn 
        195                 200                 205             


Ile Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu 
    210                 215                 220                 


Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu 
225                 230                 235                 240 


Ser Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu 
                245                 250                 255     


Asp Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly 
            260                 265                 270         


Phe Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val 
        275                 280                 285             


Glu Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu 
    290                 295                 300                 


Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys 
305                 310                 315                 320 


Leu Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu 
                325                 330                 335     


Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys 
            340                 345                 350         


Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala 
        355                 360                 365             


Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val 
    370                 375                 380                 


Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro 
385                 390                 395                 400 


Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val 
                405                 410                 415     


Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro Leu 
            420                 425                 430         


Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val Asn Leu 
        435                 440                 445             


Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly Ile Ala Ser 
    450                 455                 460                 


Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile Ser Ala Gly Ile 
465                 470                 475                 480 


Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg Asp Lys Ala Thr Lys 
                485                 490                 495     


Val Val Asp Tyr Phe Lys His Val Ser Leu Val Glu Thr Glu Gly Val 
            500                 505                 510         


Phe Thr Leu Leu Asp Asp Lys Ile Met Met Pro Gln Asp Asp Leu Val 
        515                 520                 525             


Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Val Leu Gly Lys Cys 
    530                 535                 540                 


Glu Ile Trp Arg Met Glu Gly Gly Ser Gly His Thr Val Thr Asp Asp 
545                 550                 555                 560 


Ile Asp His Phe Phe Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His 
                565                 570                 575     


Leu Ser Ile Tyr Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu 
            580                 585                 590         


Ser Lys Asp Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala 
        595                 600                 605             


Trp Glu Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly 
    610                 615                 620                 


Thr Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr 
625                 630                 635                 640 


Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys 
                645                 650                 655     


Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn Thr 
            660                 665                 670         


Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg Glu Lys 
        675                 680                 685             


Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala Leu Ser Leu 
    690                 695                 700                 


Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser Glu Ser Asp Val 
705                 710                 715                 720 


Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp Val Thr Ile Glu Ser 
                725                 730                 735     


Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu Gly Ile Leu Ser Thr Leu 
            740                 745                 750         


Ser Ile Glu Glu Asn Lys Ile Ile Leu Asn Ser His Glu Ile Asn Phe 
        755                 760                 765             


Ser Gly Glu Val Asn Gly Ser Asn Gly Phe Val Ser Leu Thr Phe Ser 
    770                 775                 780                 


Ile Leu Glu Gly Ile Asn Ala Ile Ile Glu Val Asp Leu Leu Ser Lys 
785                 790                 795                 800 


Ser Tyr Lys Leu Leu Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn 
                805                 810                 815     


Ser Asn His Ile Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu 
            820                 825                 830         


Leu Gln Lys Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu 
        835                 840                 845             


Asn Gly Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu 
    850                 855                 860                 


Leu Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys 
865                 870                 875                 880 


Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile 
                885                 890                 895     


Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp Asp 
            900                 905                 910         


Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr Ile Lys 
        915                 920                 925             


Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu Ile Leu Lys 
    930                 935                 940                 


Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp Ser Leu Met Ser 
945                 950                 955                 960 


Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe Val Asn Phe Leu Gln 
                965                 970                 975     


Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn Phe Ile Ile Ser Gly Thr 
            980                 985                 990         


Thr Ser Ile Gly Gln Phe Glu Phe  Ile Cys Asp Glu Asn  Asp Asn Ile 
        995                 1000                 1005             


Gln Pro  Tyr Phe Ile Lys Phe  Asn Thr Leu Glu Thr  Asn Tyr Thr 
    1010                 1015                 1020             


Leu Tyr  Val Gly Asn Arg Gln  Asn Met Ile Val Glu  Pro Asn Tyr 
    1025                 1030                 1035             


Asp Leu  Asp Asp Ser Gly Asp  Ile Ser Ser Thr Val  Ile Asn Phe 
    1040                 1045                 1050             


Ser Gln  Lys Tyr Leu Tyr Gly  Ile Asp Ser Cys Val  Asn Lys Val 
    1055                 1060                 1065             


Val Ile  Ser Pro Asn Ile Tyr  Thr Asp Glu Ile Asn  Ile Thr Pro 
    1070                 1075                 1080             


Val Tyr  Glu Thr Asn Asn Thr  Tyr Pro Glu Val Ile  Val Leu Asp 
    1085                 1090                 1095             


Ala Asn  Tyr Ile Asn Glu Lys  Ile Asn Val Asn Ile  Asn Asp Leu 
    1100                 1105                 1110             


Ser Ile  Arg Tyr Val Trp Ser  Asn Asp Gly Asn Asp  Phe Ile Leu 
    1115                 1120                 1125             


Met Ser  Thr Ser Glu Glu Asn  Lys Val Ser Gln Val  Lys Ile Arg 
    1130                 1135                 1140             


Phe Val  Asn Val Phe Lys Asp  Lys Thr Leu Ala Asn  Lys Leu Ser 
    1145                 1150                 1155             


Phe Asn  Phe Ser Asp Lys Gln  Asp Val Pro Val Ser  Glu Ile Ile 
    1160                 1165                 1170             


Leu Ser  Phe Thr Pro Ser Tyr  Tyr Glu Asp Gly Leu  Ile Gly Tyr 
    1175                 1180                 1185             


Asp Leu  Gly Leu Val Ser Leu  Tyr Asn Glu Lys Phe  Tyr Ile Asn 
    1190                 1195                 1200             


Asn Phe  Gly Met Met Val Ser  Gly Leu Ile Tyr Ile  Asn Asp Ser 
    1205                 1210                 1215             


Leu Tyr  Tyr Phe Lys Pro Pro  Val Asn Asn Leu Ile  Thr Gly Phe 
    1220                 1225                 1230             


Val Thr  Val Gly Asp Asp Lys  Tyr Tyr Phe Asn Pro  Ile Asn Gly 
    1235                 1240                 1245             


Gly Ala  Ala Ser Ile Gly Glu  Thr Ile Ile Asp Asp  Lys Asn Tyr 
    1250                 1255                 1260             


Tyr Phe  Asn Gln Ser Gly Val  Leu Gln Thr Gly Val  Phe Ser Thr 
    1265                 1270                 1275             


Glu Asp  Gly Phe Lys Tyr Phe  Ala Pro Ala Asn Thr  Leu Asp Glu 
    1280                 1285                 1290             


Asn Leu  Glu Gly Glu Ala Ile  Asp Phe Thr Gly Lys  Leu Ile Ile 
    1295                 1300                 1305             


Asp Glu  Asn Ile Tyr Tyr Phe  Asp Asp Asn Tyr Arg  Gly Ala Val 
    1310                 1315                 1320             


Glu Trp  Lys Glu Leu Asp Gly  Glu Met His Tyr Phe  Ser Pro Glu 
    1325                 1330                 1335             


Thr Gly  Lys Ala Phe Lys Gly  Leu Asn Gln Ile Gly  Asp Tyr Lys 
    1340                 1345                 1350             


Tyr Tyr  Phe Asn Ser Asp Gly  Val Met Gln Lys Gly  Phe Val Ser 
    1355                 1360                 1365             


Ile Asn  Asp Asn Lys His Tyr  Phe Asp Asp Ser Gly  Val Met Lys 
    1370                 1375                 1380             


Val Gly  Tyr Thr Glu Ile Asp  Gly Lys His Phe Tyr  Phe Ala Glu 
    1385                 1390                 1395             


Asn Gly  Glu Met Gln Ile Gly  Val Phe Asn Thr Glu  Asp Gly Phe 
    1400                 1405                 1410             


Lys Tyr  Phe Ala His His Asn  Glu Asp Leu Gly Asn  Glu Glu Gly 
    1415                 1420                 1425             


Glu Glu  Ile Ser Tyr Ser Gly  Ile Leu Asn Phe Asn  Asn Lys Ile 
    1430                 1435                 1440             


Tyr Tyr  Phe Asp Asp Ser Phe  Thr Ala Val Val Gly  Trp Lys Asp 
    1445                 1450                 1455             


Leu Glu  Asp Gly Ser Lys Tyr  Tyr Phe Asp Glu Asp  Thr Ala Glu 
    1460                 1465                 1470             


Ala Tyr  Ile Gly Leu Ser Leu  Ile Asn Asp Gly Gln  Tyr Tyr Phe 
    1475                 1480                 1485             


Asn Asp  Asp Gly Ile Met Gln  Val Gly Phe Val Thr  Ile Asn Asp 
    1490                 1495                 1500             


Lys Val  Phe Tyr Phe Ser Asp  Ser Gly Ile Ile Glu  Ser Gly Val 
    1505                 1510                 1515             


Gln Asn  Ile Asp Asp Asn Tyr  Phe Tyr Ile Asp Asp  Asn Gly Ile 
    1520                 1525                 1530             


Val Gln  Ile Gly Val Phe Asp  Thr Ser Asp Gly Tyr  Lys Tyr Phe 
    1535                 1540                 1545             


Ala Pro  Ala Asn Thr Val Asn  Asp Asn Ile Tyr Gly  Gln Ala Val 
    1550                 1555                 1560             


Glu Tyr  Ser Gly Leu Val Arg  Val Gly Glu Asp Val  Tyr Tyr Phe 
    1565                 1570                 1575             


Gly Glu  Thr Tyr Thr Ile Glu  Thr Gly Trp Ile Tyr  Asp Met Glu 
    1580                 1585                 1590             


Asn Glu  Ser Asp Lys Tyr Tyr  Phe Asn Pro Glu Thr  Lys Lys Ala 
    1595                 1600                 1605             


Cys Lys  Gly Ile Asn Leu Ile  Asp Asp Ile Lys Tyr  Tyr Phe Asp 
    1610                 1615                 1620             


Glu Lys  Gly Ile Met Arg Thr  Gly Leu Ile Ser Phe  Glu Asn Asn 
    1625                 1630                 1635             


Asn Tyr  Tyr Phe Asn Glu Asn  Gly Glu Met Gln Phe  Gly Tyr Ile 
    1640                 1645                 1650             


Asn Ile  Glu Asp Lys Met Phe  Tyr Phe Gly Glu Asp  Gly Val Met 
    1655                 1660                 1665             


Gln Ile  Gly Val Phe Asn Thr  Pro Asp Gly Phe Lys  Tyr Phe Ala 
    1670                 1675                 1680             


His Gln  Asn Thr Leu Asp Glu  Asn Phe Glu Gly Glu  Ser Ile Asn 
    1685                 1690                 1695             


Tyr Thr  Gly Trp Leu Asp Leu  Asp Glu Lys Arg Tyr  Tyr Phe Thr 
    1700                 1705                 1710             


Asp Glu  Tyr Ile Ala Ala Thr  Gly Ser Val Ile Ile  Asp Gly Glu 
    1715                 1720                 1725             


Glu Tyr  Tyr Phe Asp Pro Asp  Thr Ala Gln Leu Val  Ile Ser Glu 
    1730                 1735                 1740             


<210>  26
<211>  1751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  26

His His His His His His Ser His Met Ala Ser Asn Lys Glu Ile Leu 
1               5                   10                  15      


Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu Pro Arg Glu Lys 
            20                  25                  30          


Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala Thr Lys Lys Lys 
        35                  40                  45              


Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp Arg Lys Ser Gly 
    50                  55                  60                  


Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp Glu Val Thr Gln 
65                  70                  75                  80  


Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr Glu Asp Glu Ser 
                85                  90                  95      


Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu Ser Val Thr Phe 
            100                 105                 110         


Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile Val Gln Lys Val 
        115                 120                 125             


Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe Arg Glu His Glu 
    130                 135                 140                 


Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn Arg Asp Asn Ile 
145                 150                 155                 160 


Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile Leu Arg Glu Asp 
                165                 170                 175     


Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg Val Arg Gly Val 
            180                 185                 190         


Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln Leu Phe Val Thr 
        195                 200                 205             


Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg Ile Glu Val Pro 
    210                 215                 220                 


Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala Ala Arg Asp Pro 
225                 230                 235                 240 


Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp Lys Arg Ile Asp 
                245                 250                 255     


Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg Val Gln Ala Val 
            260                 265                 270         


Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val Leu Trp Asp Asp 
        275                 280                 285             


Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro Ala Asp Val Ala 
    290                 295                 300                 


Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp Ile Ala Val Glu 
305                 310                 315                 320 


Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly Gln Asn Val Arg 
                325                 330                 335     


Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val Met Thr Val Asp 
            340                 345                 350         


Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala Ala Ile Asp Thr 
        355                 360                 365             


Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala Thr Val Leu Val 
    370                 375                 380                 


Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr Val Pro Met Lys 
385                 390                 395                 400 


Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr Val Glu Ala Leu 
                405                 410                 415     


Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala Gln Ala Gln Glu 
            420                 425                 430         


Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu Leu Asn Leu Glu 
        435                 440                 445             


Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala Arg Gly Val Cys 
    450                 455                 460                 


Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp Leu Ala Asp Ile 
465                 470                 475                 480 


Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile Met Ala Ala Arg 
                485                 490                 495     


Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala Leu Val Pro Arg 
            500                 505                 510         


Gly Ser Val Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Gly Gly 
        515                 520                 525             


Ser Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn 
    530                 535                 540                 


Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly Gly 
545                 550                 555                 560 


Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser Ala Pro 
                565                 570                 575     


Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp Val Leu Glu 
            580                 585                 590         


Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu Met Val Leu Pro 
        595                 600                 605             


Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr Gly Trp Thr Pro Gly 
    610                 615                 620                 


Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys Leu Leu Asp Arg Ile Arg 
625                 630                 635                 640 


Asp Asn Tyr Glu Gly Glu Phe Tyr Trp Arg Tyr Phe Ala Phe Ile Ala 
                645                 650                 655     


Asp Ala Leu Ile Thr Thr Leu Lys Pro Arg Tyr Glu Asp Thr Asn Ile 
            660                 665                 670         


Arg Ile Asn Leu Asp Ser Asn Thr Arg Ser Phe Ile Val Pro Ile Ile 
        675                 680                 685             


Thr Thr Glu Tyr Ile Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser 
    690                 695                 700                 


Gly Gly Thr Tyr Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn 
705                 710                 715                 720 


Ile Glu Leu Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val 
                725                 730                 735     


Val Arg Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu 
            740                 745                 750         


Ile Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile 
        755                 760                 765             


Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn 
    770                 775                 780                 


Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala Ile 
785                 790                 795                 800 


Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile Ser Gly 
                805                 810                 815     


Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln Gln Lys Ile 
            820                 825                 830         


Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn Ile Pro Tyr Ser 
        835                 840                 845             


Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe Ile Asn Gly Ser Thr 
    850                 855                 860                 


Lys Glu Gly Leu Phe Val Ser Glu Leu Pro Asp Val Val Leu Ile Ser 
865                 870                 875                 880 


Lys Val Tyr Met Asp Asp Ser Lys Pro Ser Phe Gly Tyr Tyr Ser Asn 
                885                 890                 895     


Asn Leu Lys Asp Val Lys Val Ile Thr Lys Asp Asn Val Asn Ile Leu 
            900                 905                 910         


Thr Gly Tyr Tyr Leu Lys Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr 
        915                 920                 925             


Leu Gln Asp Glu Lys Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu 
    930                 935                 940                 


Ser Gly Val Ala Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr 
945                 950                 955                 960 


Asn Thr Ser Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys 
                965                 970                 975     


Ser Ile Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp 
            980                 985                 990         


Ala Asn Phe Ile Ile Ser Gly Thr  Thr Ser Ile Gly Gln  Phe Glu Phe 
        995                 1000                 1005             


Ile Cys  Asp Glu Asn Asp Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe 
    1010                 1015                 1020             


Asn Thr  Leu Glu Thr Asn Tyr  Thr Leu Tyr Val Gly  Asn Arg Gln 
    1025                 1030                 1035             


Asn Met  Ile Val Glu Pro Asn  Tyr Asp Leu Asp Asp  Ser Gly Asp 
    1040                 1045                 1050             


Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly 
    1055                 1060                 1065             


Ile Asp  Ser Cys Val Asn Lys  Val Val Ile Ser Pro  Asn Ile Tyr 
    1070                 1075                 1080             


Thr Asp  Glu Ile Asn Ile Thr  Pro Val Tyr Glu Thr  Asn Asn Thr 
    1085                 1090                 1095             


Tyr Pro  Glu Val Ile Val Leu  Asp Ala Asn Tyr Ile  Asn Glu Lys 
    1100                 1105                 1110             


Ile Asn  Val Asn Ile Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser 
    1115                 1120                 1125             


Asn Asp  Gly Asn Asp Phe Ile  Leu Met Ser Thr Ser  Glu Glu Asn 
    1130                 1135                 1140             


Lys Val  Ser Gln Val Lys Ile  Arg Phe Val Asn Val  Phe Lys Asp 
    1145                 1150                 1155             


Lys Thr  Leu Ala Asn Lys Leu  Ser Phe Asn Phe Ser  Asp Lys Gln 
    1160                 1165                 1170             


Asp Val  Pro Val Ser Glu Ile  Ile Leu Ser Phe Thr  Pro Ser Tyr 
    1175                 1180                 1185             


Tyr Glu  Asp Gly Leu Ile Gly  Tyr Asp Leu Gly Leu  Val Ser Leu 
    1190                 1195                 1200             


Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser 
    1205                 1210                 1215             


Gly Leu  Ile Tyr Ile Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro 
    1220                 1225                 1230             


Val Asn  Asn Leu Ile Thr Gly  Phe Val Thr Val Gly  Asp Asp Lys 
    1235                 1240                 1245             


Tyr Tyr  Phe Asn Pro Ile Asn  Gly Gly Ala Ala Ser  Ile Gly Glu 
    1250                 1255                 1260             


Thr Ile  Ile Asp Asp Lys Asn  Tyr Tyr Phe Asn Gln  Ser Gly Val 
    1265                 1270                 1275             


Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1280                 1285                 1290             


Ala Pro  Ala Asn Thr Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile 
    1295                 1300                 1305             


Asp Phe  Thr Gly Lys Leu Ile  Ile Asp Glu Asn Ile  Tyr Tyr Phe 
    1310                 1315                 1320             


Asp Asp  Asn Tyr Arg Gly Ala  Val Glu Trp Lys Glu  Leu Asp Gly 
    1325                 1330                 1335             


Glu Met  His Tyr Phe Ser Pro  Glu Thr Gly Lys Ala  Phe Lys Gly 
    1340                 1345                 1350             


Leu Asn  Gln Ile Gly Asp Tyr  Lys Tyr Tyr Phe Asn  Ser Asp Gly 
    1355                 1360                 1365             


Val Met  Gln Lys Gly Phe Val  Ser Ile Asn Asp Asn  Lys His Tyr 
    1370                 1375                 1380             


Phe Asp  Asp Ser Gly Val Met  Lys Val Gly Tyr Thr  Glu Ile Asp 
    1385                 1390                 1395             


Gly Lys  His Phe Tyr Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly 
    1400                 1405                 1410             


Val Phe  Asn Thr Glu Asp Gly  Phe Lys Tyr Phe Ala  His His Asn 
    1415                 1420                 1425             


Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Glu Ile Ser  Tyr Ser Gly 
    1430                 1435                 1440             


Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe 
    1445                 1450                 1455             


Thr Ala  Val Val Gly Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr 
    1460                 1465                 1470             


Tyr Phe  Asp Glu Asp Thr Ala  Glu Ala Tyr Ile Gly  Leu Ser Leu 
    1475                 1480                 1485             


Ile Asn  Asp Gly Gln Tyr Tyr  Phe Asn Asp Asp Gly  Ile Met Gln 
    1490                 1495                 1500             


Val Gly  Phe Val Thr Ile Asn  Asp Lys Val Phe Tyr  Phe Ser Asp 
    1505                 1510                 1515             


Ser Gly  Ile Ile Glu Ser Gly  Val Gln Asn Ile Asp  Asp Asn Tyr 
    1520                 1525                 1530             


Phe Tyr  Ile Asp Asp Asn Gly  Ile Val Gln Ile Gly  Val Phe Asp 
    1535                 1540                 1545             


Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn 
    1550                 1555                 1560             


Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr Ser Gly  Leu Val Arg 
    1565                 1570                 1575             


Val Gly  Glu Asp Val Tyr Tyr  Phe Gly Glu Thr Tyr  Thr Ile Glu 
    1580                 1585                 1590             


Thr Gly  Trp Ile Tyr Asp Met  Glu Asn Glu Ser Asp  Lys Tyr Tyr 
    1595                 1600                 1605             


Phe Asn  Pro Glu Thr Lys Lys  Ala Cys Lys Gly Ile  Asn Leu Ile 
    1610                 1615                 1620             


Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Lys Gly Ile  Met Arg Thr 
    1625                 1630                 1635             


Gly Leu  Ile Ser Phe Glu Asn  Asn Asn Tyr Tyr Phe  Asn Glu Asn 
    1640                 1645                 1650             


Gly Glu  Met Gln Phe Gly Tyr  Ile Asn Ile Glu Asp  Lys Met Phe 
    1655                 1660                 1665             


Tyr Phe  Gly Glu Asp Gly Val  Met Gln Ile Gly Val  Phe Asn Thr 
    1670                 1675                 1680             


Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln Asn Thr  Leu Asp Glu 
    1685                 1690                 1695             


Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu 
    1700                 1705                 1710             


Asp Glu  Lys Arg Tyr Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr 
    1715                 1720                 1725             


Gly Ser  Val Ile Ile Asp Gly  Glu Glu Tyr Tyr Phe  Asp Pro Asp 
    1730                 1735                 1740             


Thr Ala  Gln Leu Val Ile Ser  Glu 
    1745                 1750     


<210>  27
<211>  1363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  27

His His His His His His Ser His Met Ala Ser Asp Lys Ile Ile His 
1               5                   10                  15      


Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp Gly Ala 
            20                  25                  30          


Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys Met Ile 
        35                  40                  45              


Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys Leu Thr 
    50                  55                  60                  


Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro Lys Tyr 
65                  70                  75                  80  


Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly Glu Val 
                85                  90                  95      


Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys Glu Phe 
            100                 105                 110         


Leu Asp Ala Asn Leu Ala Arg Ala Leu Val Pro Arg Gly Ser Val Thr 
        115                 120                 125             


Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Gly Gly Ser Met Pro Gln 
    130                 135                 140                 


Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Val 
145                 150                 155                 160 


Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly Gly Ser Gly His Thr 
                165                 170                 175     


Val Thr Asp Asp Ile Asp His Phe Phe Ser Ala Pro Ser Ile Thr Tyr 
            180                 185                 190         


Arg Glu Pro His Leu Ser Ile Tyr Asp Val Leu Glu Val Gln Lys Glu 
        195                 200                 205             


Glu Leu Asp Leu Ser Lys Asp Leu Met Val Leu Pro Asn Ala Pro Asn 
    210                 215                 220                 


Arg Val Phe Ala Trp Glu Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu 
225                 230                 235                 240 


Glu Asn Asp Gly Thr Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu 
                245                 250                 255     


Gly Glu Phe Tyr Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile 
            260                 265                 270         


Thr Thr Leu Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu 
        275                 280                 285             


Asp Ser Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr 
    290                 295                 300                 


Ile Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr 
305                 310                 315                 320 


Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser 
                325                 330                 335     


Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp Val 
            340                 345                 350         


Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu Gly Ile 
        355                 360                 365             


Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu Asn Ser His 
    370                 375                 380                 


Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn Gly Phe Val Ser 
385                 390                 395                 400 


Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala Ile Ile Glu Val Asp 
                405                 410                 415     


Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile Ser Gly Glu Leu Lys Ile 
            420                 425                 430         


Leu Met Leu Asn Ser Asn His Ile Gln Gln Lys Ile Asp Tyr Ile Gly 
        435                 440                 445             


Phe Asn Ser Glu Leu Gln Lys Asn Ile Pro Tyr Ser Phe Val Asp Ser 
    450                 455                 460                 


Glu Gly Lys Glu Asn Gly Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu 
465                 470                 475                 480 


Phe Val Ser Glu Leu Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met 
                485                 490                 495     


Asp Asp Ser Lys Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp 
            500                 505                 510         


Val Lys Val Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr 
        515                 520                 525             


Leu Lys Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu 
    530                 535                 540                 


Lys Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala 
545                 550                 555                 560 


Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp 
                565                 570                 575     


Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe Val 
            580                 585                 590         


Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn Phe Ile 
        595                 600                 605             


Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile Cys Asp Glu 
    610                 615                 620                 


Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn Thr Leu Glu Thr 
625                 630                 635                 640 


Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn Met Ile Val Glu Pro 
                645                 650                 655     


Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile Ser Ser Thr Val Ile Asn 
            660                 665                 670         


Phe Ser Gln Lys Tyr Leu Tyr Gly Ile Asp Ser Cys Val Asn Lys Val 
        675                 680                 685             


Val Ile Ser Pro Asn Ile Tyr Thr Asp Glu Ile Asn Ile Thr Pro Val 
    690                 695                 700                 


Tyr Glu Thr Asn Asn Thr Tyr Pro Glu Val Ile Val Leu Asp Ala Asn 
705                 710                 715                 720 


Tyr Ile Asn Glu Lys Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg 
                725                 730                 735     


Tyr Val Trp Ser Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser 
            740                 745                 750         


Glu Glu Asn Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe 
        755                 760                 765             


Lys Asp Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys 
    770                 775                 780                 


Gln Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr 
785                 790                 795                 800 


Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr 
                805                 810                 815     


Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly Leu 
            820                 825                 830         


Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val Asn Asn 
        835                 840                 845             


Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr Tyr Phe Asn 
    850                 855                 860                 


Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr Ile Ile Asp Asp 
865                 870                 875                 880 


Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu Gln Thr Gly Val Phe 
                885                 890                 895     


Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asn Thr Leu Asp 
            900                 905                 910         


Glu Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys Leu Ile Ile 
        915                 920                 925             


Asp Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr Arg Gly Ala Val Glu 
    930                 935                 940                 


Trp Lys Glu Leu Asp Gly Glu Met His Tyr Phe Ser Pro Glu Thr Gly 
945                 950                 955                 960 


Lys Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe 
                965                 970                 975     


Asn Ser Asp Gly Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn 
            980                 985                 990         


Lys His Tyr Phe Asp Asp Ser Gly  Val Met Lys Val Gly  Tyr Thr Glu 
        995                 1000                 1005             


Ile Asp  Gly Lys His Phe Tyr  Phe Ala Glu Asn Gly  Glu Met Gln 
    1010                 1015                 1020             


Ile Gly  Val Phe Asn Thr Glu  Asp Gly Phe Lys Tyr  Phe Ala His 
    1025                 1030                 1035             


His Asn  Glu Asp Leu Gly Asn  Glu Glu Gly Glu Glu  Ile Ser Tyr 
    1040                 1045                 1050             


Ser Gly  Ile Leu Asn Phe Asn  Asn Lys Ile Tyr Tyr  Phe Asp Asp 
    1055                 1060                 1065             


Ser Phe  Thr Ala Val Val Gly  Trp Lys Asp Leu Glu  Asp Gly Ser 
    1070                 1075                 1080             


Lys Tyr  Tyr Phe Asp Glu Asp  Thr Ala Glu Ala Tyr  Ile Gly Leu 
    1085                 1090                 1095             


Ser Leu  Ile Asn Asp Gly Gln  Tyr Tyr Phe Asn Asp  Asp Gly Ile 
    1100                 1105                 1110             


Met Gln  Val Gly Phe Val Thr  Ile Asn Asp Lys Val  Phe Tyr Phe 
    1115                 1120                 1125             


Ser Asp  Ser Gly Ile Ile Glu  Ser Gly Val Gln Asn  Ile Asp Asp 
    1130                 1135                 1140             


Asn Tyr  Phe Tyr Ile Asp Asp  Asn Gly Ile Val Gln  Ile Gly Val 
    1145                 1150                 1155             


Phe Asp  Thr Ser Asp Gly Tyr  Lys Tyr Phe Ala Pro  Ala Asn Thr 
    1160                 1165                 1170             


Val Asn  Asp Asn Ile Tyr Gly  Gln Ala Val Glu Tyr  Ser Gly Leu 
    1175                 1180                 1185             


Val Arg  Val Gly Glu Asp Val  Tyr Tyr Phe Gly Glu  Thr Tyr Thr 
    1190                 1195                 1200             


Ile Glu  Thr Gly Trp Ile Tyr  Asp Met Glu Asn Glu  Ser Asp Lys 
    1205                 1210                 1215             


Tyr Tyr  Phe Asn Pro Glu Thr  Lys Lys Ala Cys Lys  Gly Ile Asn 
    1220                 1225                 1230             


Leu Ile  Asp Asp Ile Lys Tyr  Tyr Phe Asp Glu Lys  Gly Ile Met 
    1235                 1240                 1245             


Arg Thr  Gly Leu Ile Ser Phe  Glu Asn Asn Asn Tyr  Tyr Phe Asn 
    1250                 1255                 1260             


Glu Asn  Gly Glu Met Gln Phe  Gly Tyr Ile Asn Ile  Glu Asp Lys 
    1265                 1270                 1275             


Met Phe  Tyr Phe Gly Glu Asp  Gly Val Met Gln Ile  Gly Val Phe 
    1280                 1285                 1290             


Asn Thr  Pro Asp Gly Phe Lys  Tyr Phe Ala His Gln  Asn Thr Leu 
    1295                 1300                 1305             


Asp Glu  Asn Phe Glu Gly Glu  Ser Ile Asn Tyr Thr  Gly Trp Leu 
    1310                 1315                 1320             


Asp Leu  Asp Glu Lys Arg Tyr  Tyr Phe Thr Asp Glu  Tyr Ile Ala 
    1325                 1330                 1335             


Ala Thr  Gly Ser Val Ile Ile  Asp Gly Glu Glu Tyr  Tyr Phe Asp 
    1340                 1345                 1350             


Pro Asp  Thr Ala Gln Leu Val  Ile Ser Glu 
    1355                 1360             


<210>  28
<211>  2504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  28

His His His His His His His His His Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Ser His Met Ala Ser Asn Lys Glu Ile Leu 
        35                  40                  45              


Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu Pro Arg Glu Lys 
    50                  55                  60                  


Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala Thr Lys Lys Lys 
65                  70                  75                  80  


Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp Arg Lys Ser Gly 
                85                  90                  95      


Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp Glu Val Thr Gln 
            100                 105                 110         


Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr Glu Asp Glu Ser 
        115                 120                 125             


Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu Ser Val Thr Phe 
    130                 135                 140                 


Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile Val Gln Lys Val 
145                 150                 155                 160 


Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe Arg Glu His Glu 
                165                 170                 175     


Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn Arg Asp Asn Ile 
            180                 185                 190         


Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile Leu Arg Glu Asp 
        195                 200                 205             


Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg Val Arg Gly Val 
    210                 215                 220                 


Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln Leu Phe Val Thr 
225                 230                 235                 240 


Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg Ile Glu Val Pro 
                245                 250                 255     


Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala Ala Arg Asp Pro 
            260                 265                 270         


Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp Lys Arg Ile Asp 
        275                 280                 285             


Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg Val Gln Ala Val 
    290                 295                 300                 


Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val Leu Trp Asp Asp 
305                 310                 315                 320 


Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro Ala Asp Val Ala 
                325                 330                 335     


Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp Ile Ala Val Glu 
            340                 345                 350         


Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly Gln Asn Val Arg 
        355                 360                 365             


Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val Met Thr Val Asp 
    370                 375                 380                 


Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala Ala Ile Asp Thr 
385                 390                 395                 400 


Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala Thr Val Leu Val 
                405                 410                 415     


Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr Val Pro Met Lys 
            420                 425                 430         


Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr Val Glu Ala Leu 
        435                 440                 445             


Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala Gln Ala Gln Glu 
    450                 455                 460                 


Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu Leu Asn Leu Glu 
465                 470                 475                 480 


Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala Arg Gly Val Cys 
                485                 490                 495     


Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp Leu Ala Asp Ile 
            500                 505                 510         


Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile Met Ala Ala Arg 
        515                 520                 525             


Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala Leu Val Pro Arg 
    530                 535                 540                 


Gly Ser Val Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro 
545                 550                 555                 560 


Phe Thr Met Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe 
                565                 570                 575     


Asp Ser Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly 
            580                 585                 590         


Leu Ala Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser 
        595                 600                 605             


Val Ser Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile 
    610                 615                 620                 


Glu Ser Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val 
625                 630                 635                 640 


Lys Asn Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn 
                645                 650                 655     


Leu Leu Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn 
            660                 665                 670         


Asn Leu Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn 
        675                 680                 685             


Asn Ser Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser 
    690                 695                 700                 


Val Tyr Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His 
705                 710                 715                 720 


Ile Thr Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val 
                725                 730                 735     


Asn Gly Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val 
            740                 745                 750         


Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser 
        755                 760                 765             


Ser Asn Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln 
    770                 775                 780                 


Leu Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser 
785                 790                 795                 800 


Ile Gln Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn 
                805                 810                 815     


Val Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu 
            820                 825                 830         


Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His 
        835                 840                 845             


Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala 
    850                 855                 860                 


Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly 
865                 870                 875                 880 


Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser 
                885                 890                 895     


Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys 
            900                 905                 910         


Ala Thr Ser Val Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Lys 
        915                 920                 925             


Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp 
    930                 935                 940                 


Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu 
945                 950                 955                 960 


Gly Thr Cys Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val 
                965                 970                 975     


Thr Gly Asn Ile Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His 
            980                 985                 990         


Ile Pro Ser Leu Ser Ile Tyr Ser  Ala Ile Gly Ile Glu  Thr Glu Asn 
        995                 1000                 1005             


Leu Asp  Phe Ser Lys Lys Ile  Met Met Leu Pro Asn  Ala Pro Ser 
    1010                 1015                 1020             


Arg Val  Phe Trp Trp Glu Thr  Gly Ala Val Pro Gly  Leu Arg Ser 
    1025                 1030                 1035             


Leu Glu  Asn Asp Gly Thr Arg  Leu Leu Asp Ser Ile  Arg Asp Leu 
    1040                 1045                 1050             


Tyr Pro  Gly Lys Phe Tyr Trp  Arg Phe Tyr Ala Phe  Phe Asp Tyr 
    1055                 1060                 1065             


Ala Ile  Thr Thr Leu Lys Pro  Val Tyr Glu Asp Thr  Asn Ile Lys 
    1070                 1075                 1080             


Ile Lys  Leu Asp Lys Asp Thr  Arg Asn Phe Ile Met  Pro Thr Ile 
    1085                 1090                 1095             


Thr Thr  Asn Glu Ile Arg Asn  Lys Leu Ser Tyr Ser  Phe Asp Gly 
    1100                 1105                 1110             


Ala Gly  Gly Thr Tyr Ser Leu  Leu Leu Ser Ser Tyr  Pro Ile Ser 
    1115                 1120                 1125             


Thr Asn  Ile Asn Leu Ser Lys  Asp Asp Leu Trp Ile  Phe Asn Ile 
    1130                 1135                 1140             


Asp Asn  Glu Val Arg Glu Ile  Ser Ile Glu Asn Gly  Thr Ile Lys 
    1145                 1150                 1155             


Lys Gly  Lys Leu Ile Lys Asp  Val Leu Ser Lys Ile  Asp Ile Asn 
    1160                 1165                 1170             


Lys Asn  Lys Leu Ile Ile Gly  Asn Gln Thr Ile Asp  Phe Ser Gly 
    1175                 1180                 1185             


Asp Ile  Asp Asn Lys Asp Arg  Tyr Ile Phe Leu Thr  Cys Glu Leu 
    1190                 1195                 1200             


Asp Asp  Lys Ile Ser Leu Ile  Ile Glu Ile Asn Leu  Val Ala Lys 
    1205                 1210                 1215             


Ser Tyr  Ser Leu Leu Leu Ser  Gly Asp Lys Asn Tyr  Leu Ile Ser 
    1220                 1225                 1230             


Asn Leu  Ser Asn Ile Ile Glu  Lys Ile Asn Thr Leu  Gly Leu Asp 
    1235                 1240                 1245             


Ser Lys  Asn Ile Ala Tyr Asn  Tyr Thr Asp Glu Ser  Asn Asn Lys 
    1250                 1255                 1260             


Tyr Phe  Gly Ala Ile Ser Lys  Thr Ser Gln Lys Ser  Ile Ile His 
    1265                 1270                 1275             


Tyr Lys  Lys Asp Ser Lys Asn  Ile Leu Glu Phe Tyr  Asn Asp Ser 
    1280                 1285                 1290             


Thr Leu  Glu Phe Asn Ser Lys  Asp Phe Ile Ala Glu  Asp Ile Asn 
    1295                 1300                 1305             


Val Phe  Met Lys Asp Asp Ile  Asn Thr Ile Thr Gly  Lys Tyr Tyr 
    1310                 1315                 1320             


Val Asp  Asn Asn Thr Asp Lys  Ser Ile Asp Phe Ser  Ile Ser Leu 
    1325                 1330                 1335             


Val Ser  Lys Asn Gln Val Lys  Val Asn Gly Leu Tyr  Leu Asn Glu 
    1340                 1345                 1350             


Ser Val  Tyr Ser Ser Tyr Leu  Asp Phe Val Lys Asn  Ser Asp Gly 
    1355                 1360                 1365             


His His  Asn Thr Ser Asn Phe  Met Asn Leu Phe Leu  Asp Asn Ile 
    1370                 1375                 1380             


Ser Phe  Trp Lys Leu Phe Gly  Phe Glu Asn Ile Asn  Phe Val Ile 
    1385                 1390                 1395             


Asp Lys  Tyr Phe Thr Leu Val  Gly Lys Thr Asn Leu  Gly Tyr Val 
    1400                 1405                 1410             


Glu Phe  Ile Cys Asp Asn Asn  Lys Asn Ile Asp Ile  Tyr Phe Gly 
    1415                 1420                 1425             


Glu Trp  Lys Thr Ser Ser Ser  Lys Ser Thr Ile Phe  Ser Gly Asn 
    1430                 1435                 1440             


Gly Arg  Asn Val Val Val Glu  Pro Ile Tyr Asn Pro  Asp Thr Gly 
    1445                 1450                 1455             


Glu Asp  Ile Ser Thr Ser Leu  Asp Phe Ser Tyr Glu  Pro Leu Tyr 
    1460                 1465                 1470             


Gly Ile  Asp Arg Tyr Ile Asn  Lys Val Leu Ile Ala  Pro Asp Leu 
    1475                 1480                 1485             


Tyr Thr  Ser Leu Ile Asn Ile  Asn Thr Asn Tyr Tyr  Ser Asn Glu 
    1490                 1495                 1500             


Tyr Tyr  Pro Glu Ile Ile Val  Leu Asn Pro Asn Thr  Phe His Lys 
    1505                 1510                 1515             


Lys Val  Asn Ile Asn Leu Asp  Ser Ser Ser Phe Glu  Tyr Lys Trp 
    1520                 1525                 1530             


Ser Thr  Glu Gly Ser Asp Phe  Ile Leu Val Arg Tyr  Leu Glu Glu 
    1535                 1540                 1545             


Ser Asn  Lys Lys Ile Leu Gln  Lys Ile Arg Ile Lys  Gly Ile Leu 
    1550                 1555                 1560             


Ser Asn  Thr Gln Ser Phe Asn  Lys Met Ser Ile Asp  Phe Lys Asp 
    1565                 1570                 1575             


Ile Lys  Lys Leu Ser Leu Gly  Tyr Ile Met Ser Asn  Phe Lys Ser 
    1580                 1585                 1590             


Phe Asn  Ser Glu Asn Glu Leu  Asp Arg Asp His Leu  Gly Phe Lys 
    1595                 1600                 1605             


Ile Ile  Asp Asn Lys Thr Tyr  Tyr Tyr Asp Glu Asp  Ser Lys Leu 
    1610                 1615                 1620             


Val Lys  Gly Leu Ile Asn Ile  Asn Asn Ser Leu Phe  Tyr Phe Asp 
    1625                 1630                 1635             


Pro Ile  Glu Phe Asn Leu Val  Thr Gly Trp Gln Thr  Ile Asn Gly 
    1640                 1645                 1650             


Lys Lys  Tyr Tyr Phe Asp Ile  Asn Thr Gly Ala Ala  Leu Ile Ser 
    1655                 1660                 1665             


Tyr Lys  Ile Ile Asn Gly Lys  His Phe Tyr Phe Asn  Asn Asp Gly 
    1670                 1675                 1680             


Val Met  Gln Leu Gly Val Phe  Lys Gly Pro Asp Gly  Phe Glu Tyr 
    1685                 1690                 1695             


Phe Ala  Pro Ala Asn Thr Gln  Asn Asn Asn Ile Glu  Gly Gln Ala 
    1700                 1705                 1710             


Ile Val  Tyr Gln Ser Lys Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr 
    1715                 1720                 1725             


Tyr Phe  Asp Asn Asp Ser Lys  Ala Val Thr Gly Trp  Arg Ile Ile 
    1730                 1735                 1740             


Asn Asn  Glu Lys Tyr Tyr Phe  Asn Pro Asn Asn Ala  Ile Ala Ala 
    1745                 1750                 1755             


Val Gly  Leu Gln Val Ile Asp  Asn Asn Lys Tyr Tyr  Phe Asn Pro 
    1760                 1765                 1770             


Asp Thr  Ala Ile Ile Ser Lys  Gly Trp Gln Thr Val  Asn Gly Ser 
    1775                 1780                 1785             


Arg Tyr  Tyr Phe Asp Thr Asp  Thr Ala Ile Ala Phe  Asn Gly Tyr 
    1790                 1795                 1800             


Lys Thr  Ile Asp Gly Lys His  Phe Tyr Phe Asp Ser  Asp Cys Val 
    1805                 1810                 1815             


Val Lys  Ile Gly Val Phe Ser  Thr Ser Asn Gly Phe  Glu Tyr Phe 
    1820                 1825                 1830             


Ala Pro  Ala Asn Thr Tyr Asn  Asn Asn Ile Glu Gly  Gln Ala Ile 
    1835                 1840                 1845             


Val Tyr  Gln Ser Lys Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr 
    1850                 1855                 1860             


Phe Asp  Asn Asn Ser Lys Ala  Val Thr Gly Trp Gln  Thr Ile Asp 
    1865                 1870                 1875             


Ser Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr Ala Glu  Ala Ala Thr 
    1880                 1885                 1890             


Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn 
    1895                 1900                 1905             


Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys 
    1910                 1915                 1920             


Tyr Tyr  Phe Asn Thr Asn Thr  Ala Ile Ala Ser Thr  Gly Tyr Thr 
    1925                 1930                 1935             


Ile Ile  Asn Gly Lys His Phe  Tyr Phe Asn Thr Asp  Gly Ile Met 
    1940                 1945                 1950             


Gln Ile  Gly Val Phe Lys Gly  Pro Asn Gly Phe Glu  Tyr Phe Ala 
    1955                 1960                 1965             


Pro Ala  Asn Thr Asp Ala Asn  Asn Ile Glu Gly Gln  Ala Ile Leu 
    1970                 1975                 1980             


Tyr Gln  Asn Glu Phe Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe 
    1985                 1990                 1995             


Gly Ser  Asp Ser Lys Ala Val  Thr Gly Trp Arg Ile  Ile Asn Asn 
    2000                 2005                 2010             


Lys Lys  Tyr Tyr Phe Asn Pro  Asn Asn Ala Ile Ala  Ala Ile His 
    2015                 2020                 2025             


Leu Cys  Thr Ile Asn Asn Asp  Lys Tyr Tyr Phe Ser  Tyr Asp Gly 
    2030                 2035                 2040             


Ile Leu  Gln Asn Gly Tyr Ile  Thr Ile Glu Arg Asn  Asn Phe Tyr 
    2045                 2050                 2055             


Phe Asp  Ala Asn Asn Glu Ser  Lys Met Val Thr Gly  Val Phe Lys 
    2060                 2065                 2070             


Gly Pro  Asn Gly Phe Glu Tyr  Phe Ala Pro Ala Asn  Thr His Asn 
    2075                 2080                 2085             


Asn Asn  Ile Glu Gly Gln Ala  Ile Val Tyr Gln Asn  Lys Phe Leu 
    2090                 2095                 2100             


Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Asp Asn Asp  Ser Lys Ala 
    2105                 2110                 2115             


Val Thr  Gly Trp Gln Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn 
    2120                 2125                 2130             


Leu Asn  Thr Ala Glu Ala Ala  Thr Gly Trp Gln Thr  Ile Asp Gly 
    2135                 2140                 2145             


Lys Lys  Tyr Tyr Phe Asn Leu  Asn Thr Ala Glu Ala  Ala Thr Gly 
    2150                 2155                 2160             


Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr 
    2165                 2170                 2175             


Phe Ile  Ala Ser Thr Gly Tyr  Thr Ser Ile Asn Gly  Lys His Phe 
    2180                 2185                 2190             


Tyr Phe  Asn Thr Asp Gly Ile  Met Gln Ile Gly Val  Phe Lys Gly 
    2195                 2200                 2205             


Pro Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  His Asn Asn 
    2210                 2215                 2220             


Asn Ile  Glu Gly Gln Ala Ile  Leu Tyr Gln Asn Lys  Phe Leu Thr 
    2225                 2230                 2235             


Leu Asn  Gly Lys Lys Tyr Tyr  Phe Gly Ser Asp Ser  Lys Ala Val 
    2240                 2245                 2250             


Thr Gly  Leu Arg Thr Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr 
    2255                 2260                 2265             


Asn Thr  Ala Val Ala Val Thr  Gly Trp Gln Thr Ile  Asn Gly Lys 
    2270                 2275                 2280             


Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ser Ile Ala Ser  Thr Gly Tyr 
    2285                 2290                 2295             


Thr Ile  Ile Ser Gly Lys His  Phe Tyr Phe Asn Thr  Asp Gly Ile 
    2300                 2305                 2310             


Met Gln  Ile Gly Val Phe Lys  Gly Pro Asp Gly Phe  Glu Tyr Phe 
    2315                 2320                 2325             


Ala Pro  Ala Asn Thr Asp Ala  Asn Asn Ile Glu Gly  Gln Ala Ile 
    2330                 2335                 2340             


Arg Tyr  Gln Asn Arg Phe Leu  Tyr Leu His Asp Asn  Ile Tyr Tyr 
    2345                 2350                 2355             


Phe Gly  Asn Asn Ser Lys Ala  Ala Thr Gly Trp Val  Thr Ile Asp 
    2360                 2365                 2370             


Gly Asn  Arg Tyr Tyr Phe Glu  Pro Asn Thr Ala Met  Gly Ala Asn 
    2375                 2380                 2385             


Gly Tyr  Lys Thr Ile Asp Asn  Lys Asn Phe Tyr Phe  Arg Asn Gly 
    2390                 2395                 2400             


Leu Pro  Gln Ile Gly Val Phe  Lys Gly Ser Asn Gly  Phe Glu Tyr 
    2405                 2410                 2415             


Phe Ala  Pro Ala Asn Thr Asp  Ala Asn Asn Ile Glu  Gly Gln Ala 
    2420                 2425                 2430             


Ile Arg  Tyr Gln Asn Arg Phe  Leu His Leu Leu Gly  Lys Ile Tyr 
    2435                 2440                 2445             


Tyr Phe  Gly Asn Asn Ser Lys  Ala Val Thr Gly Trp  Gln Thr Ile 
    2450                 2455                 2460             


Asn Gly  Lys Val Tyr Tyr Phe  Met Pro Asp Thr Ala  Met Ala Ala 
    2465                 2470                 2475             


Ala Gly  Gly Leu Phe Glu Ile  Asp Gly Val Ile Tyr  Phe Phe Gly 
    2480                 2485                 2490             


Val Asp  Gly Val Lys Ala Pro  Gly Ile Tyr Gly 
    2495                 2500                 


<210>  29
<211>  2511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  29

His His His His His His His His His His Gly Gly Ser Leu Ala Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Ala Gly Gly Ser His Met 
        35                  40                  45              


Ala Ser Asn Lys Glu Ile Leu Ala Val Val Glu Ala Val Ser Asn Glu 
    50                  55                  60                  


Lys Ala Leu Pro Arg Glu Lys Ile Phe Glu Ala Leu Glu Ser Ala Leu 
65                  70                  75                  80  


Ala Thr Ala Thr Lys Lys Lys Tyr Glu Gln Glu Ile Asp Val Arg Val 
                85                  90                  95      


Gln Ile Asp Arg Lys Ser Gly Asp Phe Asp Thr Phe Arg Arg Trp Leu 
            100                 105                 110         


Val Val Asp Glu Val Thr Gln Pro Thr Lys Glu Ile Thr Leu Glu Ala 
        115                 120                 125             


Ala Arg Tyr Glu Asp Glu Ser Leu Asn Leu Gly Asp Tyr Val Glu Asp 
    130                 135                 140                 


Gln Ile Glu Ser Val Thr Phe Asp Arg Ile Thr Thr Gln Thr Ala Lys 
145                 150                 155                 160 


Gln Val Ile Val Gln Lys Val Arg Glu Ala Glu Arg Ala Met Val Val 
                165                 170                 175     


Asp Gln Phe Arg Glu His Glu Gly Glu Ile Ile Thr Gly Val Val Lys 
            180                 185                 190         


Lys Val Asn Arg Asp Asn Ile Ser Leu Asp Leu Gly Asn Asn Ala Glu 
        195                 200                 205             


Ala Val Ile Leu Arg Glu Asp Met Leu Pro Arg Glu Asn Phe Arg Pro 
    210                 215                 220                 


Gly Asp Arg Val Arg Gly Val Leu Tyr Ser Val Arg Pro Glu Ala Arg 
225                 230                 235                 240 


Gly Ala Gln Leu Phe Val Thr Arg Ser Lys Pro Glu Met Leu Ile Glu 
                245                 250                 255     


Leu Phe Arg Ile Glu Val Pro Glu Ile Gly Glu Glu Val Ile Glu Ile 
            260                 265                 270         


Lys Ala Ala Ala Arg Asp Pro Gly Ser Arg Ala Lys Ile Ala Val Lys 
        275                 280                 285             


Thr Asn Asp Lys Arg Ile Asp Pro Val Gly Ala Cys Val Gly Met Arg 
    290                 295                 300                 


Gly Ala Arg Val Gln Ala Val Ser Thr Glu Leu Gly Gly Glu Arg Ile 
305                 310                 315                 320 


Asp Ile Val Leu Trp Asp Asp Asn Pro Ala Gln Phe Val Ile Asn Ala 
                325                 330                 335     


Met Ala Pro Ala Asp Val Ala Ser Ile Val Val Asp Glu Asp Lys His 
            340                 345                 350         


Thr Met Asp Ile Ala Val Glu Ala Gly Asn Leu Ala Gln Ala Ile Gly 
        355                 360                 365             


Arg Asn Gly Gln Asn Val Arg Leu Ala Ser Gln Leu Ser Gly Trp Glu 
    370                 375                 380                 


Leu Asn Val Met Thr Val Asp Asp Leu Gln Ala Lys His Gln Ala Glu 
385                 390                 395                 400 


Ala His Ala Ala Ile Asp Thr Phe Thr Lys Tyr Leu Asp Ile Asp Glu 
                405                 410                 415     


Asp Phe Ala Thr Val Leu Val Glu Glu Gly Phe Ser Thr Leu Glu Glu 
            420                 425                 430         


Leu Ala Tyr Val Pro Met Lys Glu Leu Leu Glu Ile Glu Gly Leu Asp 
        435                 440                 445             


Glu Pro Thr Val Glu Ala Leu Arg Glu Arg Ala Lys Asn Ala Leu Ala 
    450                 455                 460                 


Thr Ile Ala Gln Ala Gln Glu Glu Ser Leu Gly Asp Asn Lys Pro Ala 
465                 470                 475                 480 


Asp Asp Leu Leu Asn Leu Glu Gly Val Asp Arg Asp Leu Ala Phe Lys 
                485                 490                 495     


Leu Ala Ala Arg Gly Val Cys Thr Leu Glu Asp Leu Ala Glu Gln Gly 
            500                 505                 510         


Ile Asp Asp Leu Ala Asp Ile Glu Gly Leu Thr Asp Glu Lys Ala Gly 
        515                 520                 525             


Ala Leu Ile Met Ala Ala Arg Asn Ile Cys Trp Phe Gly Asp Glu Ala 
    530                 535                 540                 


Ser Gly Ala Leu Val Pro Arg Gly Ser Val Thr Ser Leu Tyr Lys Lys 
545                 550                 555                 560 


Ala Gly Ser Ala Ala Ala Pro Phe Thr Met Ile Met Ser Asp Leu Ser 
                565                 570                 575     


Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile Asp Asn Lys Leu Lys Ala 
            580                 585                 590         


Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser Ile Ser Glu Asp Ile Lys 
        595                 600                 605             


Thr Leu Leu Leu Asp Ala Ser Val Ser Pro Asp Thr Lys Phe Ile Leu 
    610                 615                 620                 


Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser Ile Gly Asp Tyr Ile Tyr 
625                 630                 635                 640 


Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile Ile His Asn Ser Ile Asp 
                645                 650                 655     


Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu Asn Val Ser Asp Glu Leu 
            660                 665                 670         


Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp Glu Lys Tyr Leu Ile Ser 
        675                 680                 685             


Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr Tyr Ser Val Arg Phe Ile 
    690                 695                 700                 


Asn Lys Ser Asn Gly Glu Ser Val Tyr Val Glu Thr Glu Lys Glu Ile 
705                 710                 715                 720 


Phe Ser Lys Tyr Ser Glu His Ile Thr Lys Glu Ile Ser Thr Ile Lys 
                725                 730                 735     


Asn Ser Ile Ile Thr Asp Val Asn Gly Asn Leu Leu Asp Asn Ile Gln 
            740                 745                 750         


Leu Asp His Thr Ser Gln Val Asn Thr Leu Asn Ala Ala Phe Phe Ile 
        755                 760                 765             


Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys Asp Val Leu Asn Asp Leu 
    770                 775                 780                 


Ser Thr Ser Val Lys Val Gln Leu Tyr Ala Gln Leu Phe Ser Thr Gly 
785                 790                 795                 800 


Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu Val Asn Leu Ile Ser Asn 
                805                 810                 815     


Ala Val Asn Asp Thr Ile Asn Val Leu Pro Thr Ile Thr Glu Gly Ile 
            820                 825                 830         


Pro Ile Val Ser Thr Ile Leu Asp Gly Ile Asn Leu Gly Ala Ala Ile 
        835                 840                 845             


Lys Glu Leu Leu Asp Glu His Asp Pro Leu Leu Lys Lys Glu Leu Glu 
    850                 855                 860                 


Ala Lys Val Gly Val Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala 
865                 870                 875                 880 


Thr Val Ala Ser Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu 
                885                 890                 895     


Leu Pro Ile Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn 
            900                 905                 910         


Glu Leu Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn 
        915                 920                 925             


His Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp 
    930                 935                 940                 


Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe 
945                 950                 955                 960 


Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met Glu 
                965                 970                 975     


Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe Phe Ser 
            980                 985                 990         


Ser Pro Ser Ile Ser Ser His Ile  Pro Ser Leu Ser Ile  Tyr Ser Ala 
        995                 1000                 1005             


Ile Gly  Ile Glu Thr Glu Asn  Leu Asp Phe Ser Lys  Lys Ile Met 
    1010                 1015                 1020             


Met Leu  Pro Asn Ala Pro Ser  Arg Val Phe Trp Trp  Glu Thr Gly 
    1025                 1030                 1035             


Ala Val  Pro Gly Leu Arg Ser  Leu Glu Asn Asp Gly  Thr Arg Leu 
    1040                 1045                 1050             


Leu Asp  Ser Ile Arg Asp Leu  Tyr Pro Gly Lys Phe  Tyr Trp Arg 
    1055                 1060                 1065             


Phe Tyr  Ala Phe Phe Asp Tyr  Ala Ile Thr Thr Leu  Lys Pro Val 
    1070                 1075                 1080             


Tyr Glu  Asp Thr Asn Ile Lys  Ile Lys Leu Asp Lys  Asp Thr Arg 
    1085                 1090                 1095             


Asn Phe  Ile Met Pro Thr Ile  Thr Thr Asn Glu Ile  Arg Asn Lys 
    1100                 1105                 1110             


Leu Ser  Tyr Ser Phe Asp Gly  Ala Gly Gly Thr Tyr  Ser Leu Leu 
    1115                 1120                 1125             


Leu Ser  Ser Tyr Pro Ile Ser  Thr Asn Ile Asn Leu  Ser Lys Asp 
    1130                 1135                 1140             


Asp Leu  Trp Ile Phe Asn Ile  Asp Asn Glu Val Arg  Glu Ile Ser 
    1145                 1150                 1155             


Ile Glu  Asn Gly Thr Ile Lys  Lys Gly Lys Leu Ile  Lys Asp Val 
    1160                 1165                 1170             


Leu Ser  Lys Ile Asp Ile Asn  Lys Asn Lys Leu Ile  Ile Gly Asn 
    1175                 1180                 1185             


Gln Thr  Ile Asp Phe Ser Gly  Asp Ile Asp Asn Lys  Asp Arg Tyr 
    1190                 1195                 1200             


Ile Phe  Leu Thr Cys Glu Leu  Asp Asp Lys Ile Ser  Leu Ile Ile 
    1205                 1210                 1215             


Glu Ile  Asn Leu Val Ala Lys  Ser Tyr Ser Leu Leu  Leu Ser Gly 
    1220                 1225                 1230             


Asp Lys  Asn Tyr Leu Ile Ser  Asn Leu Ser Asn Ile  Ile Glu Lys 
    1235                 1240                 1245             


Ile Asn  Thr Leu Gly Leu Asp  Ser Lys Asn Ile Ala  Tyr Asn Tyr 
    1250                 1255                 1260             


Thr Asp  Glu Ser Asn Asn Lys  Tyr Phe Gly Ala Ile  Ser Lys Thr 
    1265                 1270                 1275             


Ser Gln  Lys Ser Ile Ile His  Tyr Lys Lys Asp Ser  Lys Asn Ile 
    1280                 1285                 1290             


Leu Glu  Phe Tyr Asn Asp Ser  Thr Leu Glu Phe Asn  Ser Lys Asp 
    1295                 1300                 1305             


Phe Ile  Ala Glu Asp Ile Asn  Val Phe Met Lys Asp  Asp Ile Asn 
    1310                 1315                 1320             


Thr Ile  Thr Gly Lys Tyr Tyr  Val Asp Asn Asn Thr  Asp Lys Ser 
    1325                 1330                 1335             


Ile Asp  Phe Ser Ile Ser Leu  Val Ser Lys Asn Gln  Val Lys Val 
    1340                 1345                 1350             


Asn Gly  Leu Tyr Leu Asn Glu  Ser Val Tyr Ser Ser  Tyr Leu Asp 
    1355                 1360                 1365             


Phe Val  Lys Asn Ser Asp Gly  His His Asn Thr Ser  Asn Phe Met 
    1370                 1375                 1380             


Asn Leu  Phe Leu Asp Asn Ile  Ser Phe Trp Lys Leu  Phe Gly Phe 
    1385                 1390                 1395             


Glu Asn  Ile Asn Phe Val Ile  Asp Lys Tyr Phe Thr  Leu Val Gly 
    1400                 1405                 1410             


Lys Thr  Asn Leu Gly Tyr Val  Glu Phe Ile Cys Asp  Asn Asn Lys 
    1415                 1420                 1425             


Asn Ile  Asp Ile Tyr Phe Gly  Glu Trp Lys Thr Ser  Ser Ser Lys 
    1430                 1435                 1440             


Ser Thr  Ile Phe Ser Gly Asn  Gly Arg Asn Val Val  Val Glu Pro 
    1445                 1450                 1455             


Ile Tyr  Asn Pro Asp Thr Gly  Glu Asp Ile Ser Thr  Ser Leu Asp 
    1460                 1465                 1470             


Phe Ser  Tyr Glu Pro Leu Tyr  Gly Ile Asp Arg Tyr  Ile Asn Lys 
    1475                 1480                 1485             


Val Leu  Ile Ala Pro Asp Leu  Tyr Thr Ser Leu Ile  Asn Ile Asn 
    1490                 1495                 1500             


Thr Asn  Tyr Tyr Ser Asn Glu  Tyr Tyr Pro Glu Ile  Ile Val Leu 
    1505                 1510                 1515             


Asn Pro  Asn Thr Phe His Lys  Lys Val Asn Ile Asn  Leu Asp Ser 
    1520                 1525                 1530             


Ser Ser  Phe Glu Tyr Lys Trp  Ser Thr Glu Gly Ser  Asp Phe Ile 
    1535                 1540                 1545             


Leu Val  Arg Tyr Leu Glu Glu  Ser Asn Lys Lys Ile  Leu Gln Lys 
    1550                 1555                 1560             


Ile Arg  Ile Lys Gly Ile Leu  Ser Asn Thr Gln Ser  Phe Asn Lys 
    1565                 1570                 1575             


Met Ser  Ile Asp Phe Lys Asp  Ile Lys Lys Leu Ser  Leu Gly Tyr 
    1580                 1585                 1590             


Ile Met  Ser Asn Phe Lys Ser  Phe Asn Ser Glu Asn  Glu Leu Asp 
    1595                 1600                 1605             


Arg Asp  His Leu Gly Phe Lys  Ile Ile Asp Asn Lys  Thr Tyr Tyr 
    1610                 1615                 1620             


Tyr Asp  Glu Asp Ser Lys Leu  Val Lys Gly Leu Ile  Asn Ile Asn 
    1625                 1630                 1635             


Asn Ser  Leu Phe Tyr Phe Asp  Pro Ile Glu Phe Asn  Leu Val Thr 
    1640                 1645                 1650             


Gly Trp  Gln Thr Ile Asn Gly  Lys Lys Tyr Tyr Phe  Asp Ile Asn 
    1655                 1660                 1665             


Thr Gly  Ala Ala Leu Ile Ser  Tyr Lys Ile Ile Asn  Gly Lys His 
    1670                 1675                 1680             


Phe Tyr  Phe Asn Asn Asp Gly  Val Met Gln Leu Gly  Val Phe Lys 
    1685                 1690                 1695             


Gly Pro  Asp Gly Phe Glu Tyr  Phe Ala Pro Ala Asn  Thr Gln Asn 
    1700                 1705                 1710             


Asn Asn  Ile Glu Gly Gln Ala  Ile Val Tyr Gln Ser  Lys Phe Leu 
    1715                 1720                 1725             


Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Asp Asn Asp  Ser Lys Ala 
    1730                 1735                 1740             


Val Thr  Gly Trp Arg Ile Ile  Asn Asn Glu Lys Tyr  Tyr Phe Asn 
    1745                 1750                 1755             


Pro Asn  Asn Ala Ile Ala Ala  Val Gly Leu Gln Val  Ile Asp Asn 
    1760                 1765                 1770             


Asn Lys  Tyr Tyr Phe Asn Pro  Asp Thr Ala Ile Ile  Ser Lys Gly 
    1775                 1780                 1785             


Trp Gln  Thr Val Asn Gly Ser  Arg Tyr Tyr Phe Asp  Thr Asp Thr 
    1790                 1795                 1800             


Ala Ile  Ala Phe Asn Gly Tyr  Lys Thr Ile Asp Gly  Lys His Phe 
    1805                 1810                 1815             


Tyr Phe  Asp Ser Asp Cys Val  Val Lys Ile Gly Val  Phe Ser Thr 
    1820                 1825                 1830             


Ser Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  Tyr Asn Asn 
    1835                 1840                 1845             


Asn Ile  Glu Gly Gln Ala Ile  Val Tyr Gln Ser Lys  Phe Leu Thr 
    1850                 1855                 1860             


Leu Asn  Gly Lys Lys Tyr Tyr  Phe Asp Asn Asn Ser  Lys Ala Val 
    1865                 1870                 1875             


Thr Gly  Trp Gln Thr Ile Asp  Ser Lys Lys Tyr Tyr  Phe Asn Thr 
    1880                 1885                 1890             


Asn Thr  Ala Glu Ala Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys 
    1895                 1900                 1905             


Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Glu Ala Ala  Thr Gly Trp 
    1910                 1915                 1920             


Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ala 
    1925                 1930                 1935             


Ile Ala  Ser Thr Gly Tyr Thr  Ile Ile Asn Gly Lys  His Phe Tyr 
    1940                 1945                 1950             


Phe Asn  Thr Asp Gly Ile Met  Gln Ile Gly Val Phe  Lys Gly Pro 
    1955                 1960                 1965             


Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn Thr Asp  Ala Asn Asn 
    1970                 1975                 1980             


Ile Glu  Gly Gln Ala Ile Leu  Tyr Gln Asn Glu Phe  Leu Thr Leu 
    1985                 1990                 1995             


Asn Gly  Lys Lys Tyr Tyr Phe  Gly Ser Asp Ser Lys  Ala Val Thr 
    2000                 2005                 2010             


Gly Trp  Arg Ile Ile Asn Asn  Lys Lys Tyr Tyr Phe  Asn Pro Asn 
    2015                 2020                 2025             


Asn Ala  Ile Ala Ala Ile His  Leu Cys Thr Ile Asn  Asn Asp Lys 
    2030                 2035                 2040             


Tyr Tyr  Phe Ser Tyr Asp Gly  Ile Leu Gln Asn Gly  Tyr Ile Thr 
    2045                 2050                 2055             


Ile Glu  Arg Asn Asn Phe Tyr  Phe Asp Ala Asn Asn  Glu Ser Lys 
    2060                 2065                 2070             


Met Val  Thr Gly Val Phe Lys  Gly Pro Asn Gly Phe  Glu Tyr Phe 
    2075                 2080                 2085             


Ala Pro  Ala Asn Thr His Asn  Asn Asn Ile Glu Gly  Gln Ala Ile 
    2090                 2095                 2100             


Val Tyr  Gln Asn Lys Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr 
    2105                 2110                 2115             


Phe Asp  Asn Asp Ser Lys Ala  Val Thr Gly Trp Gln  Thr Ile Asp 
    2120                 2125                 2130             


Gly Lys  Lys Tyr Tyr Phe Asn  Leu Asn Thr Ala Glu  Ala Ala Thr 
    2135                 2140                 2145             


Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr Tyr Phe  Asn Leu Asn 
    2150                 2155                 2160             


Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys 
    2165                 2170                 2175             


Tyr Tyr  Phe Asn Thr Asn Thr  Phe Ile Ala Ser Thr  Gly Tyr Thr 
    2180                 2185                 2190             


Ser Ile  Asn Gly Lys His Phe  Tyr Phe Asn Thr Asp  Gly Ile Met 
    2195                 2200                 2205             


Gln Ile  Gly Val Phe Lys Gly  Pro Asn Gly Phe Glu  Tyr Phe Ala 
    2210                 2215                 2220             


Pro Ala  Asn Thr His Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Leu 
    2225                 2230                 2235             


Tyr Gln  Asn Lys Phe Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe 
    2240                 2245                 2250             


Gly Ser  Asp Ser Lys Ala Val  Thr Gly Leu Arg Thr  Ile Asp Gly 
    2255                 2260                 2265             


Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ala Val Ala  Val Thr Gly 
    2270                 2275                 2280             


Trp Gln  Thr Ile Asn Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr 
    2285                 2290                 2295             


Ser Ile  Ala Ser Thr Gly Tyr  Thr Ile Ile Ser Gly  Lys His Phe 
    2300                 2305                 2310             


Tyr Phe  Asn Thr Asp Gly Ile  Met Gln Ile Gly Val  Phe Lys Gly 
    2315                 2320                 2325             


Pro Asp  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  Asp Ala Asn 
    2330                 2335                 2340             


Asn Ile  Glu Gly Gln Ala Ile  Arg Tyr Gln Asn Arg  Phe Leu Tyr 
    2345                 2350                 2355             


Leu His  Asp Asn Ile Tyr Tyr  Phe Gly Asn Asn Ser  Lys Ala Ala 
    2360                 2365                 2370             


Thr Gly  Trp Val Thr Ile Asp  Gly Asn Arg Tyr Tyr  Phe Glu Pro 
    2375                 2380                 2385             


Asn Thr  Ala Met Gly Ala Asn  Gly Tyr Lys Thr Ile  Asp Asn Lys 
    2390                 2395                 2400             


Asn Phe  Tyr Phe Arg Asn Gly  Leu Pro Gln Ile Gly  Val Phe Lys 
    2405                 2410                 2415             


Gly Ser  Asn Gly Phe Glu Tyr  Phe Ala Pro Ala Asn  Thr Asp Ala 
    2420                 2425                 2430             


Asn Asn  Ile Glu Gly Gln Ala  Ile Arg Tyr Gln Asn  Arg Phe Leu 
    2435                 2440                 2445             


His Leu  Leu Gly Lys Ile Tyr  Tyr Phe Gly Asn Asn  Ser Lys Ala 
    2450                 2455                 2460             


Val Thr  Gly Trp Gln Thr Ile  Asn Gly Lys Val Tyr  Tyr Phe Met 
    2465                 2470                 2475             


Pro Asp  Thr Ala Met Ala Ala  Ala Gly Gly Leu Phe  Glu Ile Asp 
    2480                 2485                 2490             


Gly Val  Ile Tyr Phe Phe Gly  Val Asp Gly Val Lys  Ala Pro Gly 
    2495                 2500                 2505             


Ile Tyr  Gly 
    2510     


<210>  30
<211>  2492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  30

His His His His His His Ser His Met Ala Ser Asn Lys Glu Ile Leu 
1               5                   10                  15      


Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu Pro Arg Glu Lys 
            20                  25                  30          


Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala Thr Lys Lys Lys 
        35                  40                  45              


Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp Arg Lys Ser Gly 
    50                  55                  60                  


Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp Glu Val Thr Gln 
65                  70                  75                  80  


Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr Glu Asp Glu Ser 
                85                  90                  95      


Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu Ser Val Thr Phe 
            100                 105                 110         


Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile Val Gln Lys Val 
        115                 120                 125             


Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe Arg Glu His Glu 
    130                 135                 140                 


Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn Arg Asp Asn Ile 
145                 150                 155                 160 


Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile Leu Arg Glu Asp 
                165                 170                 175     


Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg Val Arg Gly Val 
            180                 185                 190         


Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln Leu Phe Val Thr 
        195                 200                 205             


Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg Ile Glu Val Pro 
    210                 215                 220                 


Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala Ala Arg Asp Pro 
225                 230                 235                 240 


Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp Lys Arg Ile Asp 
                245                 250                 255     


Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg Val Gln Ala Val 
            260                 265                 270         


Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val Leu Trp Asp Asp 
        275                 280                 285             


Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro Ala Asp Val Ala 
    290                 295                 300                 


Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp Ile Ala Val Glu 
305                 310                 315                 320 


Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly Gln Asn Val Arg 
                325                 330                 335     


Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val Met Thr Val Asp 
            340                 345                 350         


Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala Ala Ile Asp Thr 
        355                 360                 365             


Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala Thr Val Leu Val 
    370                 375                 380                 


Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr Val Pro Met Lys 
385                 390                 395                 400 


Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr Val Glu Ala Leu 
                405                 410                 415     


Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala Gln Ala Gln Glu 
            420                 425                 430         


Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu Leu Asn Leu Glu 
        435                 440                 445             


Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala Arg Gly Val Cys 
    450                 455                 460                 


Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp Leu Ala Asp Ile 
465                 470                 475                 480 


Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile Met Ala Ala Arg 
                485                 490                 495     


Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala Leu Gly Gly Ser 
            500                 505                 510         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        515                 520                 525             


Gly Ser Gly Gly Ser Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Ser 
    530                 535                 540                 


Ala Ala Ala Pro Phe Thr Met Ile Met Ser Asp Leu Ser Ser Lys Glu 
545                 550                 555                 560 


Tyr Ile Phe Phe Asp Ser Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys 
                565                 570                 575     


Asn Ile Pro Gly Leu Ala Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu 
            580                 585                 590         


Leu Asp Ala Ser Val Ser Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu 
        595                 600                 605             


Lys Leu Asn Ile Glu Ser Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys 
    610                 615                 620                 


Leu Glu Pro Val Lys Asn Ile Ile His Asn Ser Ile Asp Asp Leu Ile 
625                 630                 635                 640 


Asp Glu Phe Asn Leu Leu Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu 
                645                 650                 655     


Lys Lys Leu Asn Asn Leu Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp 
            660                 665                 670         


Ile Ser Lys Asn Asn Ser Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser 
        675                 680                 685             


Asn Gly Glu Ser Val Tyr Val Glu Thr Glu Lys Glu Ile Phe Ser Lys 
    690                 695                 700                 


Tyr Ser Glu His Ile Thr Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile 
705                 710                 715                 720 


Ile Thr Asp Val Asn Gly Asn Leu Leu Asp Asn Ile Gln Leu Asp His 
                725                 730                 735     


Thr Ser Gln Val Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu 
            740                 745                 750         


Ile Asp Tyr Ser Ser Asn Lys Asp Val Leu Asn Asp Leu Ser Thr Ser 
        755                 760                 765             


Val Lys Val Gln Leu Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr 
    770                 775                 780                 


Ile Tyr Asp Ser Ile Gln Leu Val Asn Leu Ile Ser Asn Ala Val Asn 
785                 790                 795                 800 


Asp Thr Ile Asn Val Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val 
                805                 810                 815     


Ser Thr Ile Leu Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu 
            820                 825                 830         


Leu Asp Glu His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val 
        835                 840                 845             


Gly Val Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala 
    850                 855                 860                 


Ser Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile 
865                 870                 875                 880 


Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile 
                885                 890                 895     


Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His Leu Ser 
            900                 905                 910         


Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu 
        915                 920                 925             


Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn 
    930                 935                 940                 


Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met Glu Gly Gly Ser 
945                 950                 955                 960 


Gly His Thr Val Thr Gly Asn Ile Asp His Phe Phe Ser Ser Pro Ser 
                965                 970                 975     


Ile Ser Ser His Ile Pro Ser Leu Ser Ile Tyr Ser Ala Ile Gly Ile 
            980                 985                 990         


Glu Thr Glu Asn Leu Asp Phe Ser  Lys Lys Ile Met Met  Leu Pro Asn 
        995                 1000                 1005             


Ala Pro  Ser Arg Val Phe Trp  Trp Glu Thr Gly Ala  Val Pro Gly 
    1010                 1015                 1020             


Leu Arg  Ser Leu Glu Asn Asp  Gly Thr Arg Leu Leu  Asp Ser Ile 
    1025                 1030                 1035             


Arg Asp  Leu Tyr Pro Gly Lys  Phe Tyr Trp Arg Phe  Tyr Ala Phe 
    1040                 1045                 1050             


Phe Asp  Tyr Ala Ile Thr Thr  Leu Lys Pro Val Tyr  Glu Asp Thr 
    1055                 1060                 1065             


Asn Ile  Lys Ile Lys Leu Asp  Lys Asp Thr Arg Asn  Phe Ile Met 
    1070                 1075                 1080             


Pro Thr  Ile Thr Thr Asn Glu  Ile Arg Asn Lys Leu  Ser Tyr Ser 
    1085                 1090                 1095             


Phe Asp  Gly Ala Gly Gly Thr  Tyr Ser Leu Leu Leu  Ser Ser Tyr 
    1100                 1105                 1110             


Pro Ile  Ser Thr Asn Ile Asn  Leu Ser Lys Asp Asp  Leu Trp Ile 
    1115                 1120                 1125             


Phe Asn  Ile Asp Asn Glu Val  Arg Glu Ile Ser Ile  Glu Asn Gly 
    1130                 1135                 1140             


Thr Ile  Lys Lys Gly Lys Leu  Ile Lys Asp Val Leu  Ser Lys Ile 
    1145                 1150                 1155             


Asp Ile  Asn Lys Asn Lys Leu  Ile Ile Gly Asn Gln  Thr Ile Asp 
    1160                 1165                 1170             


Phe Ser  Gly Asp Ile Asp Asn  Lys Asp Arg Tyr Ile  Phe Leu Thr 
    1175                 1180                 1185             


Cys Glu  Leu Asp Asp Lys Ile  Ser Leu Ile Ile Glu  Ile Asn Leu 
    1190                 1195                 1200             


Val Ala  Lys Ser Tyr Ser Leu  Leu Leu Ser Gly Asp  Lys Asn Tyr 
    1205                 1210                 1215             


Leu Ile  Ser Asn Leu Ser Asn  Ile Ile Glu Lys Ile  Asn Thr Leu 
    1220                 1225                 1230             


Gly Leu  Asp Ser Lys Asn Ile  Ala Tyr Asn Tyr Thr  Asp Glu Ser 
    1235                 1240                 1245             


Asn Asn  Lys Tyr Phe Gly Ala  Ile Ser Lys Thr Ser  Gln Lys Ser 
    1250                 1255                 1260             


Ile Ile  His Tyr Lys Lys Asp  Ser Lys Asn Ile Leu  Glu Phe Tyr 
    1265                 1270                 1275             


Asn Asp  Ser Thr Leu Glu Phe  Asn Ser Lys Asp Phe  Ile Ala Glu 
    1280                 1285                 1290             


Asp Ile  Asn Val Phe Met Lys  Asp Asp Ile Asn Thr  Ile Thr Gly 
    1295                 1300                 1305             


Lys Tyr  Tyr Val Asp Asn Asn  Thr Asp Lys Ser Ile  Asp Phe Ser 
    1310                 1315                 1320             


Ile Ser  Leu Val Ser Lys Asn  Gln Val Lys Val Asn  Gly Leu Tyr 
    1325                 1330                 1335             


Leu Asn  Glu Ser Val Tyr Ser  Ser Tyr Leu Asp Phe  Val Lys Asn 
    1340                 1345                 1350             


Ser Asp  Gly His His Asn Thr  Ser Asn Phe Met Asn  Leu Phe Leu 
    1355                 1360                 1365             


Asp Asn  Ile Ser Phe Trp Lys  Leu Phe Gly Phe Glu  Asn Ile Asn 
    1370                 1375                 1380             


Phe Val  Ile Asp Lys Tyr Phe  Thr Leu Val Gly Lys  Thr Asn Leu 
    1385                 1390                 1395             


Gly Tyr  Val Glu Phe Ile Cys  Asp Asn Asn Lys Asn  Ile Asp Ile 
    1400                 1405                 1410             


Tyr Phe  Gly Glu Trp Lys Thr  Ser Ser Ser Lys Ser  Thr Ile Phe 
    1415                 1420                 1425             


Ser Gly  Asn Gly Arg Asn Val  Val Val Glu Pro Ile  Tyr Asn Pro 
    1430                 1435                 1440             


Asp Thr  Gly Glu Asp Ile Ser  Thr Ser Leu Asp Phe  Ser Tyr Glu 
    1445                 1450                 1455             


Pro Leu  Tyr Gly Ile Asp Arg  Tyr Ile Asn Lys Val  Leu Ile Ala 
    1460                 1465                 1470             


Pro Asp  Leu Tyr Thr Ser Leu  Ile Asn Ile Asn Thr  Asn Tyr Tyr 
    1475                 1480                 1485             


Ser Asn  Glu Tyr Tyr Pro Glu  Ile Ile Val Leu Asn  Pro Asn Thr 
    1490                 1495                 1500             


Phe His  Lys Lys Val Asn Ile  Asn Leu Asp Ser Ser  Ser Phe Glu 
    1505                 1510                 1515             


Tyr Lys  Trp Ser Thr Glu Gly  Ser Asp Phe Ile Leu  Val Arg Tyr 
    1520                 1525                 1530             


Leu Glu  Glu Ser Asn Lys Lys  Ile Leu Gln Lys Ile  Arg Ile Lys 
    1535                 1540                 1545             


Gly Ile  Leu Ser Asn Thr Gln  Ser Phe Asn Lys Met  Ser Ile Asp 
    1550                 1555                 1560             


Phe Lys  Asp Ile Lys Lys Leu  Ser Leu Gly Tyr Ile  Met Ser Asn 
    1565                 1570                 1575             


Phe Lys  Ser Phe Asn Ser Glu  Asn Glu Leu Asp Arg  Asp His Leu 
    1580                 1585                 1590             


Gly Phe  Lys Ile Ile Asp Asn  Lys Thr Tyr Tyr Tyr  Asp Glu Asp 
    1595                 1600                 1605             


Ser Lys  Leu Val Lys Gly Leu  Ile Asn Ile Asn Asn  Ser Leu Phe 
    1610                 1615                 1620             


Tyr Phe  Asp Pro Ile Glu Phe  Asn Leu Val Thr Gly  Trp Gln Thr 
    1625                 1630                 1635             


Ile Asn  Gly Lys Lys Tyr Tyr  Phe Asp Ile Asn Thr  Gly Ala Ala 
    1640                 1645                 1650             


Leu Ile  Ser Tyr Lys Ile Ile  Asn Gly Lys His Phe  Tyr Phe Asn 
    1655                 1660                 1665             


Asn Asp  Gly Val Met Gln Leu  Gly Val Phe Lys Gly  Pro Asp Gly 
    1670                 1675                 1680             


Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr Gln Asn Asn  Asn Ile Glu 
    1685                 1690                 1695             


Gly Gln  Ala Ile Val Tyr Gln  Ser Lys Phe Leu Thr  Leu Asn Gly 
    1700                 1705                 1710             


Lys Lys  Tyr Tyr Phe Asp Asn  Asp Ser Lys Ala Val  Thr Gly Trp 
    1715                 1720                 1725             


Arg Ile  Ile Asn Asn Glu Lys  Tyr Tyr Phe Asn Pro  Asn Asn Ala 
    1730                 1735                 1740             


Ile Ala  Ala Val Gly Leu Gln  Val Ile Asp Asn Asn  Lys Tyr Tyr 
    1745                 1750                 1755             


Phe Asn  Pro Asp Thr Ala Ile  Ile Ser Lys Gly Trp  Gln Thr Val 
    1760                 1765                 1770             


Asn Gly  Ser Arg Tyr Tyr Phe  Asp Thr Asp Thr Ala  Ile Ala Phe 
    1775                 1780                 1785             


Asn Gly  Tyr Lys Thr Ile Asp  Gly Lys His Phe Tyr  Phe Asp Ser 
    1790                 1795                 1800             


Asp Cys  Val Val Lys Ile Gly  Val Phe Ser Thr Ser  Asn Gly Phe 
    1805                 1810                 1815             


Glu Tyr  Phe Ala Pro Ala Asn  Thr Tyr Asn Asn Asn  Ile Glu Gly 
    1820                 1825                 1830             


Gln Ala  Ile Val Tyr Gln Ser  Lys Phe Leu Thr Leu  Asn Gly Lys 
    1835                 1840                 1845             


Lys Tyr  Tyr Phe Asp Asn Asn  Ser Lys Ala Val Thr  Gly Trp Gln 
    1850                 1855                 1860             


Thr Ile  Asp Ser Lys Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Glu 
    1865                 1870                 1875             


Ala Ala  Thr Gly Trp Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe 
    1880                 1885                 1890             


Asn Thr  Asn Thr Ala Glu Ala  Ala Thr Gly Trp Gln  Thr Ile Asp 
    1895                 1900                 1905             


Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr Ala Ile  Ala Ser Thr 
    1910                 1915                 1920             


Gly Tyr  Thr Ile Ile Asn Gly  Lys His Phe Tyr Phe  Asn Thr Asp 
    1925                 1930                 1935             


Gly Ile  Met Gln Ile Gly Val  Phe Lys Gly Pro Asn  Gly Phe Glu 
    1940                 1945                 1950             


Tyr Phe  Ala Pro Ala Asn Thr  Asp Ala Asn Asn Ile  Glu Gly Gln 
    1955                 1960                 1965             


Ala Ile  Leu Tyr Gln Asn Glu  Phe Leu Thr Leu Asn  Gly Lys Lys 
    1970                 1975                 1980             


Tyr Tyr  Phe Gly Ser Asp Ser  Lys Ala Val Thr Gly  Trp Arg Ile 
    1985                 1990                 1995             


Ile Asn  Asn Lys Lys Tyr Tyr  Phe Asn Pro Asn Asn  Ala Ile Ala 
    2000                 2005                 2010             


Ala Ile  His Leu Cys Thr Ile  Asn Asn Asp Lys Tyr  Tyr Phe Ser 
    2015                 2020                 2025             


Tyr Asp  Gly Ile Leu Gln Asn  Gly Tyr Ile Thr Ile  Glu Arg Asn 
    2030                 2035                 2040             


Asn Phe  Tyr Phe Asp Ala Asn  Asn Glu Ser Lys Met  Val Thr Gly 
    2045                 2050                 2055             


Val Phe  Lys Gly Pro Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn 
    2060                 2065                 2070             


Thr His  Asn Asn Asn Ile Glu  Gly Gln Ala Ile Val  Tyr Gln Asn 
    2075                 2080                 2085             


Lys Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr Tyr Phe  Asp Asn Asp 
    2090                 2095                 2100             


Ser Lys  Ala Val Thr Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr 
    2105                 2110                 2115             


Tyr Phe  Asn Leu Asn Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr 
    2120                 2125                 2130             


Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Leu Asn Thr  Ala Glu Ala 
    2135                 2140                 2145             


Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn 
    2150                 2155                 2160             


Thr Asn  Thr Phe Ile Ala Ser  Thr Gly Tyr Thr Ser  Ile Asn Gly 
    2165                 2170                 2175             


Lys His  Phe Tyr Phe Asn Thr  Asp Gly Ile Met Gln  Ile Gly Val 
    2180                 2185                 2190             


Phe Lys  Gly Pro Asn Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr 
    2195                 2200                 2205             


His Asn  Asn Asn Ile Glu Gly  Gln Ala Ile Leu Tyr  Gln Asn Lys 
    2210                 2215                 2220             


Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr Phe Gly  Ser Asp Ser 
    2225                 2230                 2235             


Lys Ala  Val Thr Gly Leu Arg  Thr Ile Asp Gly Lys  Lys Tyr Tyr 
    2240                 2245                 2250             


Phe Asn  Thr Asn Thr Ala Val  Ala Val Thr Gly Trp  Gln Thr Ile 
    2255                 2260                 2265             


Asn Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn Thr Ser  Ile Ala Ser 
    2270                 2275                 2280             


Thr Gly  Tyr Thr Ile Ile Ser  Gly Lys His Phe Tyr  Phe Asn Thr 
    2285                 2290                 2295             


Asp Gly  Ile Met Gln Ile Gly  Val Phe Lys Gly Pro  Asp Gly Phe 
    2300                 2305                 2310             


Glu Tyr  Phe Ala Pro Ala Asn  Thr Asp Ala Asn Asn  Ile Glu Gly 
    2315                 2320                 2325             


Gln Ala  Ile Arg Tyr Gln Asn  Arg Phe Leu Tyr Leu  His Asp Asn 
    2330                 2335                 2340             


Ile Tyr  Tyr Phe Gly Asn Asn  Ser Lys Ala Ala Thr  Gly Trp Val 
    2345                 2350                 2355             


Thr Ile  Asp Gly Asn Arg Tyr  Tyr Phe Glu Pro Asn  Thr Ala Met 
    2360                 2365                 2370             


Gly Ala  Asn Gly Tyr Lys Thr  Ile Asp Asn Lys Asn  Phe Tyr Phe 
    2375                 2380                 2385             


Arg Asn  Gly Leu Pro Gln Ile  Gly Val Phe Lys Gly  Ser Asn Gly 
    2390                 2395                 2400             


Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr Asp Ala Asn  Asn Ile Glu 
    2405                 2410                 2415             


Gly Gln  Ala Ile Arg Tyr Gln  Asn Arg Phe Leu His  Leu Leu Gly 
    2420                 2425                 2430             


Lys Ile  Tyr Tyr Phe Gly Asn  Asn Ser Lys Ala Val  Thr Gly Trp 
    2435                 2440                 2445             


Gln Thr  Ile Asn Gly Lys Val  Tyr Tyr Phe Met Pro  Asp Thr Ala 
    2450                 2455                 2460             


Met Ala  Ala Ala Gly Gly Leu  Phe Glu Ile Asp Gly  Val Ile Tyr 
    2465                 2470                 2475             


Phe Phe  Gly Val Asp Gly Val  Lys Ala Pro Gly Ile  Tyr Gly 
    2480                 2485                 2490         


<210>  31
<211>  2498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  31

His His His His His His Ser His Met Ala Ser Asn Lys Glu Ile Leu 
1               5                   10                  15      


Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu Pro Arg Glu Lys 
            20                  25                  30          


Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala Thr Lys Lys Lys 
        35                  40                  45              


Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp Arg Lys Ser Gly 
    50                  55                  60                  


Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp Glu Val Thr Gln 
65                  70                  75                  80  


Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr Glu Asp Glu Ser 
                85                  90                  95      


Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu Ser Val Thr Phe 
            100                 105                 110         


Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile Val Gln Lys Val 
        115                 120                 125             


Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe Arg Glu His Glu 
    130                 135                 140                 


Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn Arg Asp Asn Ile 
145                 150                 155                 160 


Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile Leu Arg Glu Asp 
                165                 170                 175     


Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg Val Arg Gly Val 
            180                 185                 190         


Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln Leu Phe Val Thr 
        195                 200                 205             


Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg Ile Glu Val Pro 
    210                 215                 220                 


Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala Ala Arg Asp Pro 
225                 230                 235                 240 


Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp Lys Arg Ile Asp 
                245                 250                 255     


Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg Val Gln Ala Val 
            260                 265                 270         


Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val Leu Trp Asp Asp 
        275                 280                 285             


Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro Ala Asp Val Ala 
    290                 295                 300                 


Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp Ile Ala Val Glu 
305                 310                 315                 320 


Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly Gln Asn Val Arg 
                325                 330                 335     


Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val Met Thr Val Asp 
            340                 345                 350         


Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala Ala Ile Asp Thr 
        355                 360                 365             


Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala Thr Val Leu Val 
    370                 375                 380                 


Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr Val Pro Met Lys 
385                 390                 395                 400 


Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr Val Glu Ala Leu 
                405                 410                 415     


Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala Gln Ala Gln Glu 
            420                 425                 430         


Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu Leu Asn Leu Glu 
        435                 440                 445             


Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala Arg Gly Val Cys 
    450                 455                 460                 


Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp Leu Ala Asp Ile 
465                 470                 475                 480 


Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile Met Ala Ala Arg 
                485                 490                 495     


Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala Leu Leu Ala Glu 
            500                 505                 510         


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
        515                 520                 525             


Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Ala Gly Gly Ser Leu Val 
    530                 535                 540                 


Pro Arg Gly Ser Gly Ser Ala Ala Ala Pro Phe Thr Met Ile Met Ser 
545                 550                 555                 560 


Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile Asp Asn Lys 
                565                 570                 575     


Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser Ile Ser Glu 
            580                 585                 590         


Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro Asp Thr Lys 
        595                 600                 605             


Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser Ile Gly Asp 
    610                 615                 620                 


Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile Ile His Asn 
625                 630                 635                 640 


Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu Asn Val Ser 
                645                 650                 655     


Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp Glu Lys Tyr 
            660                 665                 670         


Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr Tyr Ser Val 
        675                 680                 685             


Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val Glu Thr Glu 
    690                 695                 700                 


Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys Glu Ile Ser 
705                 710                 715                 720 


Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn Leu Leu Asp 
                725                 730                 735     


Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu Asn Ala Ala 
            740                 745                 750         


Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys Asp Val Leu 
        755                 760                 765             


Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala Gln Leu Phe 
    770                 775                 780                 


Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu Val Asn Leu 
785                 790                 795                 800 


Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu Pro Thr Ile Thr 
                805                 810                 815     


Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp Gly Ile Asn Leu Gly 
            820                 825                 830         


Ala Ala Ile Lys Glu Leu Leu Asp Glu His Asp Pro Leu Leu Lys Lys 
        835                 840                 845             


Glu Leu Glu Ala Lys Val Gly Val Leu Ala Ile Asn Met Ser Leu Ser 
    850                 855                 860                 


Ile Ala Ala Thr Val Ala Ser Ile Val Gly Ile Gly Ala Glu Val Thr 
865                 870                 875                 880 


Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu 
                885                 890                 895     


Val Asn Asn Glu Leu Ile Leu His Asp Lys Ala Thr Ser Val Val Asn 
            900                 905                 910         


Tyr Phe Asn His Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr 
        915                 920                 925             


Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu 
    930                 935                 940                 


Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu 
945                 950                 955                 960 


Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His 
                965                 970                 975     


Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile 
            980                 985                 990         


Tyr Ser Ala Ile Gly Ile Glu Thr  Glu Asn Leu Asp Phe  Ser Lys Lys 
        995                 1000                 1005             


Ile Met  Met Leu Pro Asn Ala  Pro Ser Arg Val Phe  Trp Trp Glu 
    1010                 1015                 1020             


Thr Gly  Ala Val Pro Gly Leu  Arg Ser Leu Glu Asn  Asp Gly Thr 
    1025                 1030                 1035             


Arg Leu  Leu Asp Ser Ile Arg  Asp Leu Tyr Pro Gly  Lys Phe Tyr 
    1040                 1045                 1050             


Trp Arg  Phe Tyr Ala Phe Phe  Asp Tyr Ala Ile Thr  Thr Leu Lys 
    1055                 1060                 1065             


Pro Val  Tyr Glu Asp Thr Asn  Ile Lys Ile Lys Leu  Asp Lys Asp 
    1070                 1075                 1080             


Thr Arg  Asn Phe Ile Met Pro  Thr Ile Thr Thr Asn  Glu Ile Arg 
    1085                 1090                 1095             


Asn Lys  Leu Ser Tyr Ser Phe  Asp Gly Ala Gly Gly  Thr Tyr Ser 
    1100                 1105                 1110             


Leu Leu  Leu Ser Ser Tyr Pro  Ile Ser Thr Asn Ile  Asn Leu Ser 
    1115                 1120                 1125             


Lys Asp  Asp Leu Trp Ile Phe  Asn Ile Asp Asn Glu  Val Arg Glu 
    1130                 1135                 1140             


Ile Ser  Ile Glu Asn Gly Thr  Ile Lys Lys Gly Lys  Leu Ile Lys 
    1145                 1150                 1155             


Asp Val  Leu Ser Lys Ile Asp  Ile Asn Lys Asn Lys  Leu Ile Ile 
    1160                 1165                 1170             


Gly Asn  Gln Thr Ile Asp Phe  Ser Gly Asp Ile Asp  Asn Lys Asp 
    1175                 1180                 1185             


Arg Tyr  Ile Phe Leu Thr Cys  Glu Leu Asp Asp Lys  Ile Ser Leu 
    1190                 1195                 1200             


Ile Ile  Glu Ile Asn Leu Val  Ala Lys Ser Tyr Ser  Leu Leu Leu 
    1205                 1210                 1215             


Ser Gly  Asp Lys Asn Tyr Leu  Ile Ser Asn Leu Ser  Asn Ile Ile 
    1220                 1225                 1230             


Glu Lys  Ile Asn Thr Leu Gly  Leu Asp Ser Lys Asn  Ile Ala Tyr 
    1235                 1240                 1245             


Asn Tyr  Thr Asp Glu Ser Asn  Asn Lys Tyr Phe Gly  Ala Ile Ser 
    1250                 1255                 1260             


Lys Thr  Ser Gln Lys Ser Ile  Ile His Tyr Lys Lys  Asp Ser Lys 
    1265                 1270                 1275             


Asn Ile  Leu Glu Phe Tyr Asn  Asp Ser Thr Leu Glu  Phe Asn Ser 
    1280                 1285                 1290             


Lys Asp  Phe Ile Ala Glu Asp  Ile Asn Val Phe Met  Lys Asp Asp 
    1295                 1300                 1305             


Ile Asn  Thr Ile Thr Gly Lys  Tyr Tyr Val Asp Asn  Asn Thr Asp 
    1310                 1315                 1320             


Lys Ser  Ile Asp Phe Ser Ile  Ser Leu Val Ser Lys  Asn Gln Val 
    1325                 1330                 1335             


Lys Val  Asn Gly Leu Tyr Leu  Asn Glu Ser Val Tyr  Ser Ser Tyr 
    1340                 1345                 1350             


Leu Asp  Phe Val Lys Asn Ser  Asp Gly His His Asn  Thr Ser Asn 
    1355                 1360                 1365             


Phe Met  Asn Leu Phe Leu Asp  Asn Ile Ser Phe Trp  Lys Leu Phe 
    1370                 1375                 1380             


Gly Phe  Glu Asn Ile Asn Phe  Val Ile Asp Lys Tyr  Phe Thr Leu 
    1385                 1390                 1395             


Val Gly  Lys Thr Asn Leu Gly  Tyr Val Glu Phe Ile  Cys Asp Asn 
    1400                 1405                 1410             


Asn Lys  Asn Ile Asp Ile Tyr  Phe Gly Glu Trp Lys  Thr Ser Ser 
    1415                 1420                 1425             


Ser Lys  Ser Thr Ile Phe Ser  Gly Asn Gly Arg Asn  Val Val Val 
    1430                 1435                 1440             


Glu Pro  Ile Tyr Asn Pro Asp  Thr Gly Glu Asp Ile  Ser Thr Ser 
    1445                 1450                 1455             


Leu Asp  Phe Ser Tyr Glu Pro  Leu Tyr Gly Ile Asp  Arg Tyr Ile 
    1460                 1465                 1470             


Asn Lys  Val Leu Ile Ala Pro  Asp Leu Tyr Thr Ser  Leu Ile Asn 
    1475                 1480                 1485             


Ile Asn  Thr Asn Tyr Tyr Ser  Asn Glu Tyr Tyr Pro  Glu Ile Ile 
    1490                 1495                 1500             


Val Leu  Asn Pro Asn Thr Phe  His Lys Lys Val Asn  Ile Asn Leu 
    1505                 1510                 1515             


Asp Ser  Ser Ser Phe Glu Tyr  Lys Trp Ser Thr Glu  Gly Ser Asp 
    1520                 1525                 1530             


Phe Ile  Leu Val Arg Tyr Leu  Glu Glu Ser Asn Lys  Lys Ile Leu 
    1535                 1540                 1545             


Gln Lys  Ile Arg Ile Lys Gly  Ile Leu Ser Asn Thr  Gln Ser Phe 
    1550                 1555                 1560             


Asn Lys  Met Ser Ile Asp Phe  Lys Asp Ile Lys Lys  Leu Ser Leu 
    1565                 1570                 1575             


Gly Tyr  Ile Met Ser Asn Phe  Lys Ser Phe Asn Ser  Glu Asn Glu 
    1580                 1585                 1590             


Leu Asp  Arg Asp His Leu Gly  Phe Lys Ile Ile Asp  Asn Lys Thr 
    1595                 1600                 1605             


Tyr Tyr  Tyr Asp Glu Asp Ser  Lys Leu Val Lys Gly  Leu Ile Asn 
    1610                 1615                 1620             


Ile Asn  Asn Ser Leu Phe Tyr  Phe Asp Pro Ile Glu  Phe Asn Leu 
    1625                 1630                 1635             


Val Thr  Gly Trp Gln Thr Ile  Asn Gly Lys Lys Tyr  Tyr Phe Asp 
    1640                 1645                 1650             


Ile Asn  Thr Gly Ala Ala Leu  Ile Ser Tyr Lys Ile  Ile Asn Gly 
    1655                 1660                 1665             


Lys His  Phe Tyr Phe Asn Asn  Asp Gly Val Met Gln  Leu Gly Val 
    1670                 1675                 1680             


Phe Lys  Gly Pro Asp Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr 
    1685                 1690                 1695             


Gln Asn  Asn Asn Ile Glu Gly  Gln Ala Ile Val Tyr  Gln Ser Lys 
    1700                 1705                 1710             


Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr Phe Asp  Asn Asp Ser 
    1715                 1720                 1725             


Lys Ala  Val Thr Gly Trp Arg  Ile Ile Asn Asn Glu  Lys Tyr Tyr 
    1730                 1735                 1740             


Phe Asn  Pro Asn Asn Ala Ile  Ala Ala Val Gly Leu  Gln Val Ile 
    1745                 1750                 1755             


Asp Asn  Asn Lys Tyr Tyr Phe  Asn Pro Asp Thr Ala  Ile Ile Ser 
    1760                 1765                 1770             


Lys Gly  Trp Gln Thr Val Asn  Gly Ser Arg Tyr Tyr  Phe Asp Thr 
    1775                 1780                 1785             


Asp Thr  Ala Ile Ala Phe Asn  Gly Tyr Lys Thr Ile  Asp Gly Lys 
    1790                 1795                 1800             


His Phe  Tyr Phe Asp Ser Asp  Cys Val Val Lys Ile  Gly Val Phe 
    1805                 1810                 1815             


Ser Thr  Ser Asn Gly Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr Tyr 
    1820                 1825                 1830             


Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Val Tyr Gln  Ser Lys Phe 
    1835                 1840                 1845             


Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe Asp Asn  Asn Ser Lys 
    1850                 1855                 1860             


Ala Val  Thr Gly Trp Gln Thr  Ile Asp Ser Lys Lys  Tyr Tyr Phe 
    1865                 1870                 1875             


Asn Thr  Asn Thr Ala Glu Ala  Ala Thr Gly Trp Gln  Thr Ile Asp 
    1880                 1885                 1890             


Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr Ala Glu  Ala Ala Thr 
    1895                 1900                 1905             


Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn 
    1910                 1915                 1920             


Thr Ala  Ile Ala Ser Thr Gly  Tyr Thr Ile Ile Asn  Gly Lys His 
    1925                 1930                 1935             


Phe Tyr  Phe Asn Thr Asp Gly  Ile Met Gln Ile Gly  Val Phe Lys 
    1940                 1945                 1950             


Gly Pro  Asn Gly Phe Glu Tyr  Phe Ala Pro Ala Asn  Thr Asp Ala 
    1955                 1960                 1965             


Asn Asn  Ile Glu Gly Gln Ala  Ile Leu Tyr Gln Asn  Glu Phe Leu 
    1970                 1975                 1980             


Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Gly Ser Asp  Ser Lys Ala 
    1985                 1990                 1995             


Val Thr  Gly Trp Arg Ile Ile  Asn Asn Lys Lys Tyr  Tyr Phe Asn 
    2000                 2005                 2010             


Pro Asn  Asn Ala Ile Ala Ala  Ile His Leu Cys Thr  Ile Asn Asn 
    2015                 2020                 2025             


Asp Lys  Tyr Tyr Phe Ser Tyr  Asp Gly Ile Leu Gln  Asn Gly Tyr 
    2030                 2035                 2040             


Ile Thr  Ile Glu Arg Asn Asn  Phe Tyr Phe Asp Ala  Asn Asn Glu 
    2045                 2050                 2055             


Ser Lys  Met Val Thr Gly Val  Phe Lys Gly Pro Asn  Gly Phe Glu 
    2060                 2065                 2070             


Tyr Phe  Ala Pro Ala Asn Thr  His Asn Asn Asn Ile  Glu Gly Gln 
    2075                 2080                 2085             


Ala Ile  Val Tyr Gln Asn Lys  Phe Leu Thr Leu Asn  Gly Lys Lys 
    2090                 2095                 2100             


Tyr Tyr  Phe Asp Asn Asp Ser  Lys Ala Val Thr Gly  Trp Gln Thr 
    2105                 2110                 2115             


Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Leu Asn Thr  Ala Glu Ala 
    2120                 2125                 2130             


Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn 
    2135                 2140                 2145             


Leu Asn  Thr Ala Glu Ala Ala  Thr Gly Trp Gln Thr  Ile Asp Gly 
    2150                 2155                 2160             


Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Phe Ile Ala  Ser Thr Gly 
    2165                 2170                 2175             


Tyr Thr  Ser Ile Asn Gly Lys  His Phe Tyr Phe Asn  Thr Asp Gly 
    2180                 2185                 2190             


Ile Met  Gln Ile Gly Val Phe  Lys Gly Pro Asn Gly  Phe Glu Tyr 
    2195                 2200                 2205             


Phe Ala  Pro Ala Asn Thr His  Asn Asn Asn Ile Glu  Gly Gln Ala 
    2210                 2215                 2220             


Ile Leu  Tyr Gln Asn Lys Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr 
    2225                 2230                 2235             


Tyr Phe  Gly Ser Asp Ser Lys  Ala Val Thr Gly Leu  Arg Thr Ile 
    2240                 2245                 2250             


Asp Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn Thr Ala  Val Ala Val 
    2255                 2260                 2265             


Thr Gly  Trp Gln Thr Ile Asn  Gly Lys Lys Tyr Tyr  Phe Asn Thr 
    2270                 2275                 2280             


Asn Thr  Ser Ile Ala Ser Thr  Gly Tyr Thr Ile Ile  Ser Gly Lys 
    2285                 2290                 2295             


His Phe  Tyr Phe Asn Thr Asp  Gly Ile Met Gln Ile  Gly Val Phe 
    2300                 2305                 2310             


Lys Gly  Pro Asp Gly Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr Asp 
    2315                 2320                 2325             


Ala Asn  Asn Ile Glu Gly Gln  Ala Ile Arg Tyr Gln  Asn Arg Phe 
    2330                 2335                 2340             


Leu Tyr  Leu His Asp Asn Ile  Tyr Tyr Phe Gly Asn  Asn Ser Lys 
    2345                 2350                 2355             


Ala Ala  Thr Gly Trp Val Thr  Ile Asp Gly Asn Arg  Tyr Tyr Phe 
    2360                 2365                 2370             


Glu Pro  Asn Thr Ala Met Gly  Ala Asn Gly Tyr Lys  Thr Ile Asp 
    2375                 2380                 2385             


Asn Lys  Asn Phe Tyr Phe Arg  Asn Gly Leu Pro Gln  Ile Gly Val 
    2390                 2395                 2400             


Phe Lys  Gly Ser Asn Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr 
    2405                 2410                 2415             


Asp Ala  Asn Asn Ile Glu Gly  Gln Ala Ile Arg Tyr  Gln Asn Arg 
    2420                 2425                 2430             


Phe Leu  His Leu Leu Gly Lys  Ile Tyr Tyr Phe Gly  Asn Asn Ser 
    2435                 2440                 2445             


Lys Ala  Val Thr Gly Trp Gln  Thr Ile Asn Gly Lys  Val Tyr Tyr 
    2450                 2455                 2460             


Phe Met  Pro Asp Thr Ala Met  Ala Ala Ala Gly Gly  Leu Phe Glu 
    2465                 2470                 2475             


Ile Asp  Gly Val Ile Tyr Phe  Phe Gly Val Asp Gly  Val Lys Ala 
    2480                 2485                 2490             


Pro Gly  Ile Tyr Gly 
    2495             


<210>  32
<211>  2143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  32

His His His His His His His His His Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Ser His Met Ala Ser Asn Lys Glu Ile Leu 
        35                  40                  45              


Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu Pro Arg Glu Lys 
    50                  55                  60                  


Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala Thr Lys Lys Lys 
65                  70                  75                  80  


Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp Arg Lys Ser Gly 
                85                  90                  95      


Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp Glu Val Thr Gln 
            100                 105                 110         


Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr Glu Asp Glu Ser 
        115                 120                 125             


Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu Ser Val Thr Phe 
    130                 135                 140                 


Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile Val Gln Lys Val 
145                 150                 155                 160 


Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe Arg Glu His Glu 
                165                 170                 175     


Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn Arg Asp Asn Ile 
            180                 185                 190         


Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile Leu Arg Glu Asp 
        195                 200                 205             


Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg Val Arg Gly Val 
    210                 215                 220                 


Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln Leu Phe Val Thr 
225                 230                 235                 240 


Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg Ile Glu Val Pro 
                245                 250                 255     


Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala Ala Arg Asp Pro 
            260                 265                 270         


Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp Lys Arg Ile Asp 
        275                 280                 285             


Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg Val Gln Ala Val 
    290                 295                 300                 


Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val Leu Trp Asp Asp 
305                 310                 315                 320 


Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro Ala Asp Val Ala 
                325                 330                 335     


Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp Ile Ala Val Glu 
            340                 345                 350         


Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly Gln Asn Val Arg 
        355                 360                 365             


Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val Met Thr Val Asp 
    370                 375                 380                 


Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala Ala Ile Asp Thr 
385                 390                 395                 400 


Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala Thr Val Leu Val 
                405                 410                 415     


Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr Val Pro Met Lys 
            420                 425                 430         


Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr Val Glu Ala Leu 
        435                 440                 445             


Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala Gln Ala Gln Glu 
    450                 455                 460                 


Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu Leu Asn Leu Glu 
465                 470                 475                 480 


Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala Arg Gly Val Cys 
                485                 490                 495     


Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp Leu Ala Asp Ile 
            500                 505                 510         


Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile Met Ala Ala Arg 
        515                 520                 525             


Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala Leu Val Pro Arg 
    530                 535                 540                 


Gly Ser Val Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro 
545                 550                 555                 560 


Phe Thr Met Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp 
                565                 570                 575     


Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe 
            580                 585                 590         


Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met Glu 
        595                 600                 605             


Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe Phe Ser 
    610                 615                 620                 


Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile Tyr Ser Ala 
625                 630                 635                 640 


Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys Lys Ile Met Met 
                645                 650                 655     


Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp Glu Thr Gly Ala Val 
            660                 665                 670         


Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Arg Leu Leu Asp Ser 
        675                 680                 685             


Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr Trp Arg Phe Tyr Ala Phe 
    690                 695                 700                 


Phe Asp Tyr Ala Ile Thr Thr Leu Lys Pro Val Tyr Glu Asp Thr Asn 
705                 710                 715                 720 


Ile Lys Ile Lys Leu Asp Lys Asp Thr Arg Asn Phe Ile Met Pro Thr 
                725                 730                 735     


Ile Thr Thr Asn Glu Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly 
            740                 745                 750         


Ala Gly Gly Thr Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr 
        755                 760                 765             


Asn Ile Asn Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn 
    770                 775                 780                 


Glu Val Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys 
785                 790                 795                 800 


Leu Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu 
                805                 810                 815     


Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys 
            820                 825                 830         


Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser Leu 
        835                 840                 845             


Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu Leu Ser 
    850                 855                 860                 


Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Ile Ile Glu Lys 
865                 870                 875                 880 


Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala Tyr Asn Tyr Thr 
                885                 890                 895     


Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile Ser Lys Thr Ser Gln 
            900                 905                 910         


Lys Ser Ile Ile His Tyr Lys Lys Asp Ser Lys Asn Ile Leu Glu Phe 
        915                 920                 925             


Tyr Asn Asp Ser Thr Leu Glu Phe Asn Ser Lys Asp Phe Ile Ala Glu 
    930                 935                 940                 


Asp Ile Asn Val Phe Met Lys Asp Asp Ile Asn Thr Ile Thr Gly Lys 
945                 950                 955                 960 


Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser 
                965                 970                 975     


Leu Val Ser Lys Asn Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu 
            980                 985                 990         


Ser Val Tyr Ser Ser Tyr Leu Asp  Phe Val Lys Asn Ser  Asp Gly His 
        995                 1000                 1005             


His Asn  Thr Ser Asn Phe Met  Asn Leu Phe Leu Asp  Asn Ile Ser 
    1010                 1015                 1020             


Phe Trp  Lys Leu Phe Gly Phe  Glu Asn Ile Asn Phe  Val Ile Asp 
    1025                 1030                 1035             


Lys Tyr  Phe Thr Leu Val Gly  Lys Thr Asn Leu Gly  Tyr Val Glu 
    1040                 1045                 1050             


Phe Ile  Cys Asp Asn Asn Lys  Asn Ile Asp Ile Tyr  Phe Gly Glu 
    1055                 1060                 1065             


Trp Lys  Thr Ser Ser Ser Lys  Ser Thr Ile Phe Ser  Gly Asn Gly 
    1070                 1075                 1080             


Arg Asn  Val Val Val Glu Pro  Ile Tyr Asn Pro Asp  Thr Gly Glu 
    1085                 1090                 1095             


Asp Ile  Ser Thr Ser Leu Asp  Phe Ser Tyr Glu Pro  Leu Tyr Gly 
    1100                 1105                 1110             


Ile Asp  Arg Tyr Ile Asn Lys  Val Leu Ile Ala Pro  Asp Leu Tyr 
    1115                 1120                 1125             


Thr Ser  Leu Ile Asn Ile Asn  Thr Asn Tyr Tyr Ser  Asn Glu Tyr 
    1130                 1135                 1140             


Tyr Pro  Glu Ile Ile Val Leu  Asn Pro Asn Thr Phe  His Lys Lys 
    1145                 1150                 1155             


Val Asn  Ile Asn Leu Asp Ser  Ser Ser Phe Glu Tyr  Lys Trp Ser 
    1160                 1165                 1170             


Thr Glu  Gly Ser Asp Phe Ile  Leu Val Arg Tyr Leu  Glu Glu Ser 
    1175                 1180                 1185             


Asn Lys  Lys Ile Leu Gln Lys  Ile Arg Ile Lys Gly  Ile Leu Ser 
    1190                 1195                 1200             


Asn Thr  Gln Ser Phe Asn Lys  Met Ser Ile Asp Phe  Lys Asp Ile 
    1205                 1210                 1215             


Lys Lys  Leu Ser Leu Gly Tyr  Ile Met Ser Asn Phe  Lys Ser Phe 
    1220                 1225                 1230             


Asn Ser  Glu Asn Glu Leu Asp  Arg Asp His Leu Gly  Phe Lys Ile 
    1235                 1240                 1245             


Ile Asp  Asn Lys Thr Tyr Tyr  Tyr Asp Glu Asp Ser  Lys Leu Val 
    1250                 1255                 1260             


Lys Gly  Leu Ile Asn Ile Asn  Asn Ser Leu Phe Tyr  Phe Asp Pro 
    1265                 1270                 1275             


Ile Glu  Phe Asn Leu Val Thr  Gly Trp Gln Thr Ile  Asn Gly Lys 
    1280                 1285                 1290             


Lys Tyr  Tyr Phe Asp Ile Asn  Thr Gly Ala Ala Leu  Ile Ser Tyr 
    1295                 1300                 1305             


Lys Ile  Ile Asn Gly Lys His  Phe Tyr Phe Asn Asn  Asp Gly Val 
    1310                 1315                 1320             


Met Gln  Leu Gly Val Phe Lys  Gly Pro Asp Gly Phe  Glu Tyr Phe 
    1325                 1330                 1335             


Ala Pro  Ala Asn Thr Gln Asn  Asn Asn Ile Glu Gly  Gln Ala Ile 
    1340                 1345                 1350             


Val Tyr  Gln Ser Lys Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr 
    1355                 1360                 1365             


Phe Asp  Asn Asp Ser Lys Ala  Val Thr Gly Trp Arg  Ile Ile Asn 
    1370                 1375                 1380             


Asn Glu  Lys Tyr Tyr Phe Asn  Pro Asn Asn Ala Ile  Ala Ala Val 
    1385                 1390                 1395             


Gly Leu  Gln Val Ile Asp Asn  Asn Lys Tyr Tyr Phe  Asn Pro Asp 
    1400                 1405                 1410             


Thr Ala  Ile Ile Ser Lys Gly  Trp Gln Thr Val Asn  Gly Ser Arg 
    1415                 1420                 1425             


Tyr Tyr  Phe Asp Thr Asp Thr  Ala Ile Ala Phe Asn  Gly Tyr Lys 
    1430                 1435                 1440             


Thr Ile  Asp Gly Lys His Phe  Tyr Phe Asp Ser Asp  Cys Val Val 
    1445                 1450                 1455             


Lys Ile  Gly Val Phe Ser Thr  Ser Asn Gly Phe Glu  Tyr Phe Ala 
    1460                 1465                 1470             


Pro Ala  Asn Thr Tyr Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Val 
    1475                 1480                 1485             


Tyr Gln  Ser Lys Phe Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe 
    1490                 1495                 1500             


Asp Asn  Asn Ser Lys Ala Val  Thr Gly Trp Gln Thr  Ile Asp Ser 
    1505                 1510                 1515             


Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ala Glu Ala  Ala Thr Gly 
    1520                 1525                 1530             


Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr 
    1535                 1540                 1545             


Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr 
    1550                 1555                 1560             


Tyr Phe  Asn Thr Asn Thr Ala  Ile Ala Ser Thr Gly  Tyr Thr Ile 
    1565                 1570                 1575             


Ile Asn  Gly Lys His Phe Tyr  Phe Asn Thr Asp Gly  Ile Met Gln 
    1580                 1585                 1590             


Ile Gly  Val Phe Lys Gly Pro  Asn Gly Phe Glu Tyr  Phe Ala Pro 
    1595                 1600                 1605             


Ala Asn  Thr Asp Ala Asn Asn  Ile Glu Gly Gln Ala  Ile Leu Tyr 
    1610                 1615                 1620             


Gln Asn  Glu Phe Leu Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Gly 
    1625                 1630                 1635             


Ser Asp  Ser Lys Ala Val Thr  Gly Trp Arg Ile Ile  Asn Asn Lys 
    1640                 1645                 1650             


Lys Tyr  Tyr Phe Asn Pro Asn  Asn Ala Ile Ala Ala  Ile His Leu 
    1655                 1660                 1665             


Cys Thr  Ile Asn Asn Asp Lys  Tyr Tyr Phe Ser Tyr  Asp Gly Ile 
    1670                 1675                 1680             


Leu Gln  Asn Gly Tyr Ile Thr  Ile Glu Arg Asn Asn  Phe Tyr Phe 
    1685                 1690                 1695             


Asp Ala  Asn Asn Glu Ser Lys  Met Val Thr Gly Val  Phe Lys Gly 
    1700                 1705                 1710             


Pro Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  His Asn Asn 
    1715                 1720                 1725             


Asn Ile  Glu Gly Gln Ala Ile  Val Tyr Gln Asn Lys  Phe Leu Thr 
    1730                 1735                 1740             


Leu Asn  Gly Lys Lys Tyr Tyr  Phe Asp Asn Asp Ser  Lys Ala Val 
    1745                 1750                 1755             


Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Leu 
    1760                 1765                 1770             


Asn Thr  Ala Glu Ala Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys 
    1775                 1780                 1785             


Lys Tyr  Tyr Phe Asn Leu Asn  Thr Ala Glu Ala Ala  Thr Gly Trp 
    1790                 1795                 1800             


Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Phe 
    1805                 1810                 1815             


Ile Ala  Ser Thr Gly Tyr Thr  Ser Ile Asn Gly Lys  His Phe Tyr 
    1820                 1825                 1830             


Phe Asn  Thr Asp Gly Ile Met  Gln Ile Gly Val Phe  Lys Gly Pro 
    1835                 1840                 1845             


Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn Thr His  Asn Asn Asn 
    1850                 1855                 1860             


Ile Glu  Gly Gln Ala Ile Leu  Tyr Gln Asn Lys Phe  Leu Thr Leu 
    1865                 1870                 1875             


Asn Gly  Lys Lys Tyr Tyr Phe  Gly Ser Asp Ser Lys  Ala Val Thr 
    1880                 1885                 1890             


Gly Leu  Arg Thr Ile Asp Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn 
    1895                 1900                 1905             


Thr Ala  Val Ala Val Thr Gly  Trp Gln Thr Ile Asn  Gly Lys Lys 
    1910                 1915                 1920             


Tyr Tyr  Phe Asn Thr Asn Thr  Ser Ile Ala Ser Thr  Gly Tyr Thr 
    1925                 1930                 1935             


Ile Ile  Ser Gly Lys His Phe  Tyr Phe Asn Thr Asp  Gly Ile Met 
    1940                 1945                 1950             


Gln Ile  Gly Val Phe Lys Gly  Pro Asp Gly Phe Glu  Tyr Phe Ala 
    1955                 1960                 1965             


Pro Ala  Asn Thr Asp Ala Asn  Asn Ile Glu Gly Gln  Ala Ile Arg 
    1970                 1975                 1980             


Tyr Gln  Asn Arg Phe Leu Tyr  Leu His Asp Asn Ile  Tyr Tyr Phe 
    1985                 1990                 1995             


Gly Asn  Asn Ser Lys Ala Ala  Thr Gly Trp Val Thr  Ile Asp Gly 
    2000                 2005                 2010             


Asn Arg  Tyr Tyr Phe Glu Pro  Asn Thr Ala Met Gly  Ala Asn Gly 
    2015                 2020                 2025             


Tyr Lys  Thr Ile Asp Asn Lys  Asn Phe Tyr Phe Arg  Asn Gly Leu 
    2030                 2035                 2040             


Pro Gln  Ile Gly Val Phe Lys  Gly Ser Asn Gly Phe  Glu Tyr Phe 
    2045                 2050                 2055             


Ala Pro  Ala Asn Thr Asp Ala  Asn Asn Ile Glu Gly  Gln Ala Ile 
    2060                 2065                 2070             


Arg Tyr  Gln Asn Arg Phe Leu  His Leu Leu Gly Lys  Ile Tyr Tyr 
    2075                 2080                 2085             


Phe Gly  Asn Asn Ser Lys Ala  Val Thr Gly Trp Gln  Thr Ile Asn 
    2090                 2095                 2100             


Gly Lys  Val Tyr Tyr Phe Met  Pro Asp Thr Ala Met  Ala Ala Ala 
    2105                 2110                 2115             


Gly Gly  Leu Phe Glu Ile Asp  Gly Val Ile Tyr Phe  Phe Gly Val 
    2120                 2125                 2130             


Asp Gly  Val Lys Ala Pro Gly  Ile Tyr Gly 
    2135                 2140             


<210>  33
<211>  2150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  33

His His His His His His His His His His Gly Gly Ser Leu Ala Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Ala Gly Gly Ser His Met 
        35                  40                  45              


Ala Ser Asn Lys Glu Ile Leu Ala Val Val Glu Ala Val Ser Asn Glu 
    50                  55                  60                  


Lys Ala Leu Pro Arg Glu Lys Ile Phe Glu Ala Leu Glu Ser Ala Leu 
65                  70                  75                  80  


Ala Thr Ala Thr Lys Lys Lys Tyr Glu Gln Glu Ile Asp Val Arg Val 
                85                  90                  95      


Gln Ile Asp Arg Lys Ser Gly Asp Phe Asp Thr Phe Arg Arg Trp Leu 
            100                 105                 110         


Val Val Asp Glu Val Thr Gln Pro Thr Lys Glu Ile Thr Leu Glu Ala 
        115                 120                 125             


Ala Arg Tyr Glu Asp Glu Ser Leu Asn Leu Gly Asp Tyr Val Glu Asp 
    130                 135                 140                 


Gln Ile Glu Ser Val Thr Phe Asp Arg Ile Thr Thr Gln Thr Ala Lys 
145                 150                 155                 160 


Gln Val Ile Val Gln Lys Val Arg Glu Ala Glu Arg Ala Met Val Val 
                165                 170                 175     


Asp Gln Phe Arg Glu His Glu Gly Glu Ile Ile Thr Gly Val Val Lys 
            180                 185                 190         


Lys Val Asn Arg Asp Asn Ile Ser Leu Asp Leu Gly Asn Asn Ala Glu 
        195                 200                 205             


Ala Val Ile Leu Arg Glu Asp Met Leu Pro Arg Glu Asn Phe Arg Pro 
    210                 215                 220                 


Gly Asp Arg Val Arg Gly Val Leu Tyr Ser Val Arg Pro Glu Ala Arg 
225                 230                 235                 240 


Gly Ala Gln Leu Phe Val Thr Arg Ser Lys Pro Glu Met Leu Ile Glu 
                245                 250                 255     


Leu Phe Arg Ile Glu Val Pro Glu Ile Gly Glu Glu Val Ile Glu Ile 
            260                 265                 270         


Lys Ala Ala Ala Arg Asp Pro Gly Ser Arg Ala Lys Ile Ala Val Lys 
        275                 280                 285             


Thr Asn Asp Lys Arg Ile Asp Pro Val Gly Ala Cys Val Gly Met Arg 
    290                 295                 300                 


Gly Ala Arg Val Gln Ala Val Ser Thr Glu Leu Gly Gly Glu Arg Ile 
305                 310                 315                 320 


Asp Ile Val Leu Trp Asp Asp Asn Pro Ala Gln Phe Val Ile Asn Ala 
                325                 330                 335     


Met Ala Pro Ala Asp Val Ala Ser Ile Val Val Asp Glu Asp Lys His 
            340                 345                 350         


Thr Met Asp Ile Ala Val Glu Ala Gly Asn Leu Ala Gln Ala Ile Gly 
        355                 360                 365             


Arg Asn Gly Gln Asn Val Arg Leu Ala Ser Gln Leu Ser Gly Trp Glu 
    370                 375                 380                 


Leu Asn Val Met Thr Val Asp Asp Leu Gln Ala Lys His Gln Ala Glu 
385                 390                 395                 400 


Ala His Ala Ala Ile Asp Thr Phe Thr Lys Tyr Leu Asp Ile Asp Glu 
                405                 410                 415     


Asp Phe Ala Thr Val Leu Val Glu Glu Gly Phe Ser Thr Leu Glu Glu 
            420                 425                 430         


Leu Ala Tyr Val Pro Met Lys Glu Leu Leu Glu Ile Glu Gly Leu Asp 
        435                 440                 445             


Glu Pro Thr Val Glu Ala Leu Arg Glu Arg Ala Lys Asn Ala Leu Ala 
    450                 455                 460                 


Thr Ile Ala Gln Ala Gln Glu Glu Ser Leu Gly Asp Asn Lys Pro Ala 
465                 470                 475                 480 


Asp Asp Leu Leu Asn Leu Glu Gly Val Asp Arg Asp Leu Ala Phe Lys 
                485                 490                 495     


Leu Ala Ala Arg Gly Val Cys Thr Leu Glu Asp Leu Ala Glu Gln Gly 
            500                 505                 510         


Ile Asp Asp Leu Ala Asp Ile Glu Gly Leu Thr Asp Glu Lys Ala Gly 
        515                 520                 525             


Ala Leu Ile Met Ala Ala Arg Asn Ile Cys Trp Phe Gly Asp Glu Ala 
    530                 535                 540                 


Ser Gly Ala Leu Val Pro Arg Gly Ser Val Thr Ser Leu Tyr Lys Lys 
545                 550                 555                 560 


Ala Gly Ser Ala Ala Ala Pro Phe Thr Met Glu Ser Lys Lys Tyr Gly 
                565                 570                 575     


Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu 
            580                 585                 590         


Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr 
        595                 600                 605             


Cys Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly 
    610                 615                 620                 


Asn Ile Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro 
625                 630                 635                 640 


Ser Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp 
                645                 650                 655     


Phe Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe 
            660                 665                 670         


Trp Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp 
        675                 680                 685             


Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe 
    690                 695                 700                 


Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys 
705                 710                 715                 720 


Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp Thr 
                725                 730                 735     


Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg Asn Lys 
            740                 745                 750         


Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu 
        755                 760                 765             


Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp Asp Leu 
    770                 775                 780                 


Trp Ile Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn 
785                 790                 795                 800 


Gly Thr Ile Lys Lys Gly Lys Leu Ile Lys Asp Val Leu Ser Lys Ile 
                805                 810                 815     


Asp Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe 
            820                 825                 830         


Ser Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu 
        835                 840                 845             


Leu Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys 
    850                 855                 860                 


Ser Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn 
865                 870                 875                 880 


Leu Ser Asn Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys 
                885                 890                 895     


Asn Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly 
            900                 905                 910         


Ala Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp 
        915                 920                 925             


Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn 
    930                 935                 940                 


Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp 
945                 950                 955                 960 


Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys 
                965                 970                 975     


Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val 
            980                 985                 990         


Asn Gly Leu Tyr Leu Asn Glu Ser  Val Tyr Ser Ser Tyr  Leu Asp Phe 
        995                 1000                 1005             


Val Lys  Asn Ser Asp Gly His  His Asn Thr Ser Asn  Phe Met Asn 
    1010                 1015                 1020             


Leu Phe  Leu Asp Asn Ile Ser  Phe Trp Lys Leu Phe  Gly Phe Glu 
    1025                 1030                 1035             


Asn Ile  Asn Phe Val Ile Asp  Lys Tyr Phe Thr Leu  Val Gly Lys 
    1040                 1045                 1050             


Thr Asn  Leu Gly Tyr Val Glu  Phe Ile Cys Asp Asn  Asn Lys Asn 
    1055                 1060                 1065             


Ile Asp  Ile Tyr Phe Gly Glu  Trp Lys Thr Ser Ser  Ser Lys Ser 
    1070                 1075                 1080             


Thr Ile  Phe Ser Gly Asn Gly  Arg Asn Val Val Val  Glu Pro Ile 
    1085                 1090                 1095             


Tyr Asn  Pro Asp Thr Gly Glu  Asp Ile Ser Thr Ser  Leu Asp Phe 
    1100                 1105                 1110             


Ser Tyr  Glu Pro Leu Tyr Gly  Ile Asp Arg Tyr Ile  Asn Lys Val 
    1115                 1120                 1125             


Leu Ile  Ala Pro Asp Leu Tyr  Thr Ser Leu Ile Asn  Ile Asn Thr 
    1130                 1135                 1140             


Asn Tyr  Tyr Ser Asn Glu Tyr  Tyr Pro Glu Ile Ile  Val Leu Asn 
    1145                 1150                 1155             


Pro Asn  Thr Phe His Lys Lys  Val Asn Ile Asn Leu  Asp Ser Ser 
    1160                 1165                 1170             


Ser Phe  Glu Tyr Lys Trp Ser  Thr Glu Gly Ser Asp  Phe Ile Leu 
    1175                 1180                 1185             


Val Arg  Tyr Leu Glu Glu Ser  Asn Lys Lys Ile Leu  Gln Lys Ile 
    1190                 1195                 1200             


Arg Ile  Lys Gly Ile Leu Ser  Asn Thr Gln Ser Phe  Asn Lys Met 
    1205                 1210                 1215             


Ser Ile  Asp Phe Lys Asp Ile  Lys Lys Leu Ser Leu  Gly Tyr Ile 
    1220                 1225                 1230             


Met Ser  Asn Phe Lys Ser Phe  Asn Ser Glu Asn Glu  Leu Asp Arg 
    1235                 1240                 1245             


Asp His  Leu Gly Phe Lys Ile  Ile Asp Asn Lys Thr  Tyr Tyr Tyr 
    1250                 1255                 1260             


Asp Glu  Asp Ser Lys Leu Val  Lys Gly Leu Ile Asn  Ile Asn Asn 
    1265                 1270                 1275             


Ser Leu  Phe Tyr Phe Asp Pro  Ile Glu Phe Asn Leu  Val Thr Gly 
    1280                 1285                 1290             


Trp Gln  Thr Ile Asn Gly Lys  Lys Tyr Tyr Phe Asp  Ile Asn Thr 
    1295                 1300                 1305             


Gly Ala  Ala Leu Ile Ser Tyr  Lys Ile Ile Asn Gly  Lys His Phe 
    1310                 1315                 1320             


Tyr Phe  Asn Asn Asp Gly Val  Met Gln Leu Gly Val  Phe Lys Gly 
    1325                 1330                 1335             


Pro Asp  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  Gln Asn Asn 
    1340                 1345                 1350             


Asn Ile  Glu Gly Gln Ala Ile  Val Tyr Gln Ser Lys  Phe Leu Thr 
    1355                 1360                 1365             


Leu Asn  Gly Lys Lys Tyr Tyr  Phe Asp Asn Asp Ser  Lys Ala Val 
    1370                 1375                 1380             


Thr Gly  Trp Arg Ile Ile Asn  Asn Glu Lys Tyr Tyr  Phe Asn Pro 
    1385                 1390                 1395             


Asn Asn  Ala Ile Ala Ala Val  Gly Leu Gln Val Ile  Asp Asn Asn 
    1400                 1405                 1410             


Lys Tyr  Tyr Phe Asn Pro Asp  Thr Ala Ile Ile Ser  Lys Gly Trp 
    1415                 1420                 1425             


Gln Thr  Val Asn Gly Ser Arg  Tyr Tyr Phe Asp Thr  Asp Thr Ala 
    1430                 1435                 1440             


Ile Ala  Phe Asn Gly Tyr Lys  Thr Ile Asp Gly Lys  His Phe Tyr 
    1445                 1450                 1455             


Phe Asp  Ser Asp Cys Val Val  Lys Ile Gly Val Phe  Ser Thr Ser 
    1460                 1465                 1470             


Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn Thr Tyr  Asn Asn Asn 
    1475                 1480                 1485             


Ile Glu  Gly Gln Ala Ile Val  Tyr Gln Ser Lys Phe  Leu Thr Leu 
    1490                 1495                 1500             


Asn Gly  Lys Lys Tyr Tyr Phe  Asp Asn Asn Ser Lys  Ala Val Thr 
    1505                 1510                 1515             


Gly Trp  Gln Thr Ile Asp Ser  Lys Lys Tyr Tyr Phe  Asn Thr Asn 
    1520                 1525                 1530             


Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys 
    1535                 1540                 1545             


Tyr Tyr  Phe Asn Thr Asn Thr  Ala Glu Ala Ala Thr  Gly Trp Gln 
    1550                 1555                 1560             


Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Ile 
    1565                 1570                 1575             


Ala Ser  Thr Gly Tyr Thr Ile  Ile Asn Gly Lys His  Phe Tyr Phe 
    1580                 1585                 1590             


Asn Thr  Asp Gly Ile Met Gln  Ile Gly Val Phe Lys  Gly Pro Asn 
    1595                 1600                 1605             


Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr Asp Ala  Asn Asn Ile 
    1610                 1615                 1620             


Glu Gly  Gln Ala Ile Leu Tyr  Gln Asn Glu Phe Leu  Thr Leu Asn 
    1625                 1630                 1635             


Gly Lys  Lys Tyr Tyr Phe Gly  Ser Asp Ser Lys Ala  Val Thr Gly 
    1640                 1645                 1650             


Trp Arg  Ile Ile Asn Asn Lys  Lys Tyr Tyr Phe Asn  Pro Asn Asn 
    1655                 1660                 1665             


Ala Ile  Ala Ala Ile His Leu  Cys Thr Ile Asn Asn  Asp Lys Tyr 
    1670                 1675                 1680             


Tyr Phe  Ser Tyr Asp Gly Ile  Leu Gln Asn Gly Tyr  Ile Thr Ile 
    1685                 1690                 1695             


Glu Arg  Asn Asn Phe Tyr Phe  Asp Ala Asn Asn Glu  Ser Lys Met 
    1700                 1705                 1710             


Val Thr  Gly Val Phe Lys Gly  Pro Asn Gly Phe Glu  Tyr Phe Ala 
    1715                 1720                 1725             


Pro Ala  Asn Thr His Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Val 
    1730                 1735                 1740             


Tyr Gln  Asn Lys Phe Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe 
    1745                 1750                 1755             


Asp Asn  Asp Ser Lys Ala Val  Thr Gly Trp Gln Thr  Ile Asp Gly 
    1760                 1765                 1770             


Lys Lys  Tyr Tyr Phe Asn Leu  Asn Thr Ala Glu Ala  Ala Thr Gly 
    1775                 1780                 1785             


Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr Phe Asn  Leu Asn Thr 
    1790                 1795                 1800             


Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr 
    1805                 1810                 1815             


Tyr Phe  Asn Thr Asn Thr Phe  Ile Ala Ser Thr Gly  Tyr Thr Ser 
    1820                 1825                 1830             


Ile Asn  Gly Lys His Phe Tyr  Phe Asn Thr Asp Gly  Ile Met Gln 
    1835                 1840                 1845             


Ile Gly  Val Phe Lys Gly Pro  Asn Gly Phe Glu Tyr  Phe Ala Pro 
    1850                 1855                 1860             


Ala Asn  Thr His Asn Asn Asn  Ile Glu Gly Gln Ala  Ile Leu Tyr 
    1865                 1870                 1875             


Gln Asn  Lys Phe Leu Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Gly 
    1880                 1885                 1890             


Ser Asp  Ser Lys Ala Val Thr  Gly Leu Arg Thr Ile  Asp Gly Lys 
    1895                 1900                 1905             


Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Val Ala Val  Thr Gly Trp 
    1910                 1915                 1920             


Gln Thr  Ile Asn Gly Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ser 
    1925                 1930                 1935             


Ile Ala  Ser Thr Gly Tyr Thr  Ile Ile Ser Gly Lys  His Phe Tyr 
    1940                 1945                 1950             


Phe Asn  Thr Asp Gly Ile Met  Gln Ile Gly Val Phe  Lys Gly Pro 
    1955                 1960                 1965             


Asp Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn Thr Asp  Ala Asn Asn 
    1970                 1975                 1980             


Ile Glu  Gly Gln Ala Ile Arg  Tyr Gln Asn Arg Phe  Leu Tyr Leu 
    1985                 1990                 1995             


His Asp  Asn Ile Tyr Tyr Phe  Gly Asn Asn Ser Lys  Ala Ala Thr 
    2000                 2005                 2010             


Gly Trp  Val Thr Ile Asp Gly  Asn Arg Tyr Tyr Phe  Glu Pro Asn 
    2015                 2020                 2025             


Thr Ala  Met Gly Ala Asn Gly  Tyr Lys Thr Ile Asp  Asn Lys Asn 
    2030                 2035                 2040             


Phe Tyr  Phe Arg Asn Gly Leu  Pro Gln Ile Gly Val  Phe Lys Gly 
    2045                 2050                 2055             


Ser Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  Asp Ala Asn 
    2060                 2065                 2070             


Asn Ile  Glu Gly Gln Ala Ile  Arg Tyr Gln Asn Arg  Phe Leu His 
    2075                 2080                 2085             


Leu Leu  Gly Lys Ile Tyr Tyr  Phe Gly Asn Asn Ser  Lys Ala Val 
    2090                 2095                 2100             


Thr Gly  Trp Gln Thr Ile Asn  Gly Lys Val Tyr Tyr  Phe Met Pro 
    2105                 2110                 2115             


Asp Thr  Ala Met Ala Ala Ala  Gly Gly Leu Phe Glu  Ile Asp Gly 
    2120                 2125                 2130             


Val Ile  Tyr Phe Phe Gly Val  Asp Gly Val Lys Ala  Pro Gly Ile 
    2135                 2140                 2145             


Tyr Gly  
    2150 


<210>  34
<211>  2131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  34

His His His His His His Ser His Met Ala Ser Asn Lys Glu Ile Leu 
1               5                   10                  15      


Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu Pro Arg Glu Lys 
            20                  25                  30          


Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala Thr Lys Lys Lys 
        35                  40                  45              


Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp Arg Lys Ser Gly 
    50                  55                  60                  


Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp Glu Val Thr Gln 
65                  70                  75                  80  


Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr Glu Asp Glu Ser 
                85                  90                  95      


Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu Ser Val Thr Phe 
            100                 105                 110         


Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile Val Gln Lys Val 
        115                 120                 125             


Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe Arg Glu His Glu 
    130                 135                 140                 


Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn Arg Asp Asn Ile 
145                 150                 155                 160 


Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile Leu Arg Glu Asp 
                165                 170                 175     


Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg Val Arg Gly Val 
            180                 185                 190         


Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln Leu Phe Val Thr 
        195                 200                 205             


Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg Ile Glu Val Pro 
    210                 215                 220                 


Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala Ala Arg Asp Pro 
225                 230                 235                 240 


Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp Lys Arg Ile Asp 
                245                 250                 255     


Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg Val Gln Ala Val 
            260                 265                 270         


Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val Leu Trp Asp Asp 
        275                 280                 285             


Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro Ala Asp Val Ala 
    290                 295                 300                 


Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp Ile Ala Val Glu 
305                 310                 315                 320 


Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly Gln Asn Val Arg 
                325                 330                 335     


Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val Met Thr Val Asp 
            340                 345                 350         


Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala Ala Ile Asp Thr 
        355                 360                 365             


Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala Thr Val Leu Val 
    370                 375                 380                 


Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr Val Pro Met Lys 
385                 390                 395                 400 


Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr Val Glu Ala Leu 
                405                 410                 415     


Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala Gln Ala Gln Glu 
            420                 425                 430         


Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu Leu Asn Leu Glu 
        435                 440                 445             


Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala Arg Gly Val Cys 
    450                 455                 460                 


Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp Leu Ala Asp Ile 
465                 470                 475                 480 


Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile Met Ala Ala Arg 
                485                 490                 495     


Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala Leu Gly Gly Ser 
            500                 505                 510         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        515                 520                 525             


Gly Ser Gly Gly Ser Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Ser 
    530                 535                 540                 


Ala Ala Ala Pro Phe Thr Met Glu Ser Lys Lys Tyr Gly Pro Leu Lys 
545                 550                 555                 560 


Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser 
                565                 570                 575     


Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile 
            580                 585                 590         


Leu Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp 
        595                 600                 605             


His Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser 
    610                 615                 620                 


Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys 
625                 630                 635                 640 


Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp Glu 
                645                 650                 655     


Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Arg 
            660                 665                 670         


Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr Trp Arg 
        675                 680                 685             


Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys Pro Val Tyr 
    690                 695                 700                 


Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp Thr Arg Asn Phe 
705                 710                 715                 720 


Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg Asn Lys Leu Ser Tyr 
                725                 730                 735     


Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu Ser Ser Tyr 
            740                 745                 750         


Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp Asp Leu Trp Ile Phe 
        755                 760                 765             


Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile 
    770                 775                 780                 


Lys Lys Gly Lys Leu Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn 
785                 790                 795                 800 


Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp 
                805                 810                 815     


Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp 
            820                 825                 830         


Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser 
        835                 840                 845             


Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn 
    850                 855                 860                 


Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala 
865                 870                 875                 880 


Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile Ser 
                885                 890                 895     


Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser Lys Asn 
            900                 905                 910         


Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn Ser Lys Asp 
        915                 920                 925             


Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp Ile Asn Thr 
    930                 935                 940                 


Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser Ile Asp 
945                 950                 955                 960 


Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val Asn Gly Leu 
                965                 970                 975     


Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val Lys Asn 
            980                 985                 990         


Ser Asp Gly His His Asn Thr Ser  Asn Phe Met Asn Leu  Phe Leu Asp 
        995                 1000                 1005             


Asn Ile  Ser Phe Trp Lys Leu  Phe Gly Phe Glu Asn  Ile Asn Phe 
    1010                 1015                 1020             


Val Ile  Asp Lys Tyr Phe Thr  Leu Val Gly Lys Thr  Asn Leu Gly 
    1025                 1030                 1035             


Tyr Val  Glu Phe Ile Cys Asp  Asn Asn Lys Asn Ile  Asp Ile Tyr 
    1040                 1045                 1050             


Phe Gly  Glu Trp Lys Thr Ser  Ser Ser Lys Ser Thr  Ile Phe Ser 
    1055                 1060                 1065             


Gly Asn  Gly Arg Asn Val Val  Val Glu Pro Ile Tyr  Asn Pro Asp 
    1070                 1075                 1080             


Thr Gly  Glu Asp Ile Ser Thr  Ser Leu Asp Phe Ser  Tyr Glu Pro 
    1085                 1090                 1095             


Leu Tyr  Gly Ile Asp Arg Tyr  Ile Asn Lys Val Leu  Ile Ala Pro 
    1100                 1105                 1110             


Asp Leu  Tyr Thr Ser Leu Ile  Asn Ile Asn Thr Asn  Tyr Tyr Ser 
    1115                 1120                 1125             


Asn Glu  Tyr Tyr Pro Glu Ile  Ile Val Leu Asn Pro  Asn Thr Phe 
    1130                 1135                 1140             


His Lys  Lys Val Asn Ile Asn  Leu Asp Ser Ser Ser  Phe Glu Tyr 
    1145                 1150                 1155             


Lys Trp  Ser Thr Glu Gly Ser  Asp Phe Ile Leu Val  Arg Tyr Leu 
    1160                 1165                 1170             


Glu Glu  Ser Asn Lys Lys Ile  Leu Gln Lys Ile Arg  Ile Lys Gly 
    1175                 1180                 1185             


Ile Leu  Ser Asn Thr Gln Ser  Phe Asn Lys Met Ser  Ile Asp Phe 
    1190                 1195                 1200             


Lys Asp  Ile Lys Lys Leu Ser  Leu Gly Tyr Ile Met  Ser Asn Phe 
    1205                 1210                 1215             


Lys Ser  Phe Asn Ser Glu Asn  Glu Leu Asp Arg Asp  His Leu Gly 
    1220                 1225                 1230             


Phe Lys  Ile Ile Asp Asn Lys  Thr Tyr Tyr Tyr Asp  Glu Asp Ser 
    1235                 1240                 1245             


Lys Leu  Val Lys Gly Leu Ile  Asn Ile Asn Asn Ser  Leu Phe Tyr 
    1250                 1255                 1260             


Phe Asp  Pro Ile Glu Phe Asn  Leu Val Thr Gly Trp  Gln Thr Ile 
    1265                 1270                 1275             


Asn Gly  Lys Lys Tyr Tyr Phe  Asp Ile Asn Thr Gly  Ala Ala Leu 
    1280                 1285                 1290             


Ile Ser  Tyr Lys Ile Ile Asn  Gly Lys His Phe Tyr  Phe Asn Asn 
    1295                 1300                 1305             


Asp Gly  Val Met Gln Leu Gly  Val Phe Lys Gly Pro  Asp Gly Phe 
    1310                 1315                 1320             


Glu Tyr  Phe Ala Pro Ala Asn  Thr Gln Asn Asn Asn  Ile Glu Gly 
    1325                 1330                 1335             


Gln Ala  Ile Val Tyr Gln Ser  Lys Phe Leu Thr Leu  Asn Gly Lys 
    1340                 1345                 1350             


Lys Tyr  Tyr Phe Asp Asn Asp  Ser Lys Ala Val Thr  Gly Trp Arg 
    1355                 1360                 1365             


Ile Ile  Asn Asn Glu Lys Tyr  Tyr Phe Asn Pro Asn  Asn Ala Ile 
    1370                 1375                 1380             


Ala Ala  Val Gly Leu Gln Val  Ile Asp Asn Asn Lys  Tyr Tyr Phe 
    1385                 1390                 1395             


Asn Pro  Asp Thr Ala Ile Ile  Ser Lys Gly Trp Gln  Thr Val Asn 
    1400                 1405                 1410             


Gly Ser  Arg Tyr Tyr Phe Asp  Thr Asp Thr Ala Ile  Ala Phe Asn 
    1415                 1420                 1425             


Gly Tyr  Lys Thr Ile Asp Gly  Lys His Phe Tyr Phe  Asp Ser Asp 
    1430                 1435                 1440             


Cys Val  Val Lys Ile Gly Val  Phe Ser Thr Ser Asn  Gly Phe Glu 
    1445                 1450                 1455             


Tyr Phe  Ala Pro Ala Asn Thr  Tyr Asn Asn Asn Ile  Glu Gly Gln 
    1460                 1465                 1470             


Ala Ile  Val Tyr Gln Ser Lys  Phe Leu Thr Leu Asn  Gly Lys Lys 
    1475                 1480                 1485             


Tyr Tyr  Phe Asp Asn Asn Ser  Lys Ala Val Thr Gly  Trp Gln Thr 
    1490                 1495                 1500             


Ile Asp  Ser Lys Lys Tyr Tyr  Phe Asn Thr Asn Thr  Ala Glu Ala 
    1505                 1510                 1515             


Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn 
    1520                 1525                 1530             


Thr Asn  Thr Ala Glu Ala Ala  Thr Gly Trp Gln Thr  Ile Asp Gly 
    1535                 1540                 1545             


Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ala Ile Ala  Ser Thr Gly 
    1550                 1555                 1560             


Tyr Thr  Ile Ile Asn Gly Lys  His Phe Tyr Phe Asn  Thr Asp Gly 
    1565                 1570                 1575             


Ile Met  Gln Ile Gly Val Phe  Lys Gly Pro Asn Gly  Phe Glu Tyr 
    1580                 1585                 1590             


Phe Ala  Pro Ala Asn Thr Asp  Ala Asn Asn Ile Glu  Gly Gln Ala 
    1595                 1600                 1605             


Ile Leu  Tyr Gln Asn Glu Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr 
    1610                 1615                 1620             


Tyr Phe  Gly Ser Asp Ser Lys  Ala Val Thr Gly Trp  Arg Ile Ile 
    1625                 1630                 1635             


Asn Asn  Lys Lys Tyr Tyr Phe  Asn Pro Asn Asn Ala  Ile Ala Ala 
    1640                 1645                 1650             


Ile His  Leu Cys Thr Ile Asn  Asn Asp Lys Tyr Tyr  Phe Ser Tyr 
    1655                 1660                 1665             


Asp Gly  Ile Leu Gln Asn Gly  Tyr Ile Thr Ile Glu  Arg Asn Asn 
    1670                 1675                 1680             


Phe Tyr  Phe Asp Ala Asn Asn  Glu Ser Lys Met Val  Thr Gly Val 
    1685                 1690                 1695             


Phe Lys  Gly Pro Asn Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr 
    1700                 1705                 1710             


His Asn  Asn Asn Ile Glu Gly  Gln Ala Ile Val Tyr  Gln Asn Lys 
    1715                 1720                 1725             


Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr Phe Asp  Asn Asp Ser 
    1730                 1735                 1740             


Lys Ala  Val Thr Gly Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr 
    1745                 1750                 1755             


Phe Asn  Leu Asn Thr Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile 
    1760                 1765                 1770             


Asp Gly  Lys Lys Tyr Tyr Phe  Asn Leu Asn Thr Ala  Glu Ala Ala 
    1775                 1780                 1785             


Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr 
    1790                 1795                 1800             


Asn Thr  Phe Ile Ala Ser Thr  Gly Tyr Thr Ser Ile  Asn Gly Lys 
    1805                 1810                 1815             


His Phe  Tyr Phe Asn Thr Asp  Gly Ile Met Gln Ile  Gly Val Phe 
    1820                 1825                 1830             


Lys Gly  Pro Asn Gly Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr His 
    1835                 1840                 1845             


Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Leu Tyr Gln  Asn Lys Phe 
    1850                 1855                 1860             


Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe Gly Ser  Asp Ser Lys 
    1865                 1870                 1875             


Ala Val  Thr Gly Leu Arg Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe 
    1880                 1885                 1890             


Asn Thr  Asn Thr Ala Val Ala  Val Thr Gly Trp Gln  Thr Ile Asn 
    1895                 1900                 1905             


Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr Ser Ile  Ala Ser Thr 
    1910                 1915                 1920             


Gly Tyr  Thr Ile Ile Ser Gly  Lys His Phe Tyr Phe  Asn Thr Asp 
    1925                 1930                 1935             


Gly Ile  Met Gln Ile Gly Val  Phe Lys Gly Pro Asp  Gly Phe Glu 
    1940                 1945                 1950             


Tyr Phe  Ala Pro Ala Asn Thr  Asp Ala Asn Asn Ile  Glu Gly Gln 
    1955                 1960                 1965             


Ala Ile  Arg Tyr Gln Asn Arg  Phe Leu Tyr Leu His  Asp Asn Ile 
    1970                 1975                 1980             


Tyr Tyr  Phe Gly Asn Asn Ser  Lys Ala Ala Thr Gly  Trp Val Thr 
    1985                 1990                 1995             


Ile Asp  Gly Asn Arg Tyr Tyr  Phe Glu Pro Asn Thr  Ala Met Gly 
    2000                 2005                 2010             


Ala Asn  Gly Tyr Lys Thr Ile  Asp Asn Lys Asn Phe  Tyr Phe Arg 
    2015                 2020                 2025             


Asn Gly  Leu Pro Gln Ile Gly  Val Phe Lys Gly Ser  Asn Gly Phe 
    2030                 2035                 2040             


Glu Tyr  Phe Ala Pro Ala Asn  Thr Asp Ala Asn Asn  Ile Glu Gly 
    2045                 2050                 2055             


Gln Ala  Ile Arg Tyr Gln Asn  Arg Phe Leu His Leu  Leu Gly Lys 
    2060                 2065                 2070             


Ile Tyr  Tyr Phe Gly Asn Asn  Ser Lys Ala Val Thr  Gly Trp Gln 
    2075                 2080                 2085             


Thr Ile  Asn Gly Lys Val Tyr  Tyr Phe Met Pro Asp  Thr Ala Met 
    2090                 2095                 2100             


Ala Ala  Ala Gly Gly Leu Phe  Glu Ile Asp Gly Val  Ile Tyr Phe 
    2105                 2110                 2115             


Phe Gly  Val Asp Gly Val Lys  Ala Pro Gly Ile Tyr  Gly 
    2120                 2125                 2130     


<210>  35
<211>  2137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  35

His His His His His His Ser His Met Ala Ser Asn Lys Glu Ile Leu 
1               5                   10                  15      


Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu Pro Arg Glu Lys 
            20                  25                  30          


Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala Thr Lys Lys Lys 
        35                  40                  45              


Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp Arg Lys Ser Gly 
    50                  55                  60                  


Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp Glu Val Thr Gln 
65                  70                  75                  80  


Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr Glu Asp Glu Ser 
                85                  90                  95      


Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu Ser Val Thr Phe 
            100                 105                 110         


Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile Val Gln Lys Val 
        115                 120                 125             


Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe Arg Glu His Glu 
    130                 135                 140                 


Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn Arg Asp Asn Ile 
145                 150                 155                 160 


Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile Leu Arg Glu Asp 
                165                 170                 175     


Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg Val Arg Gly Val 
            180                 185                 190         


Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln Leu Phe Val Thr 
        195                 200                 205             


Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg Ile Glu Val Pro 
    210                 215                 220                 


Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala Ala Arg Asp Pro 
225                 230                 235                 240 


Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp Lys Arg Ile Asp 
                245                 250                 255     


Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg Val Gln Ala Val 
            260                 265                 270         


Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val Leu Trp Asp Asp 
        275                 280                 285             


Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro Ala Asp Val Ala 
    290                 295                 300                 


Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp Ile Ala Val Glu 
305                 310                 315                 320 


Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly Gln Asn Val Arg 
                325                 330                 335     


Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val Met Thr Val Asp 
            340                 345                 350         


Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala Ala Ile Asp Thr 
        355                 360                 365             


Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala Thr Val Leu Val 
    370                 375                 380                 


Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr Val Pro Met Lys 
385                 390                 395                 400 


Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr Val Glu Ala Leu 
                405                 410                 415     


Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala Gln Ala Gln Glu 
            420                 425                 430         


Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu Leu Asn Leu Glu 
        435                 440                 445             


Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala Arg Gly Val Cys 
    450                 455                 460                 


Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp Leu Ala Asp Ile 
465                 470                 475                 480 


Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile Met Ala Ala Arg 
                485                 490                 495     


Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala Leu Leu Ala Glu 
            500                 505                 510         


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
        515                 520                 525             


Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Ala Gly Gly Ser Leu Val 
    530                 535                 540                 


Pro Arg Gly Ser Gly Ser Ala Ala Ala Pro Phe Thr Met Glu Ser Lys 
545                 550                 555                 560 


Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile 
                565                 570                 575     


Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys 
            580                 585                 590         


Leu Gly Thr Cys Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr 
        595                 600                 605             


Val Thr Gly Asn Ile Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser 
    610                 615                 620                 


His Ile Pro Ser Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu 
625                 630                 635                 640 


Asn Leu Asp Phe Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser 
                645                 650                 655     


Arg Val Phe Trp Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu 
            660                 665                 670         


Glu Asn Asp Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro 
        675                 680                 685             


Gly Lys Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr 
    690                 695                 700                 


Thr Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp 
705                 710                 715                 720 


Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile 
                725                 730                 735     


Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser 
            740                 745                 750         


Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys 
        755                 760                 765             


Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser 
    770                 775                 780                 


Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile Lys Asp Val Leu 
785                 790                 795                 800 


Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr 
                805                 810                 815     


Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu 
            820                 825                 830         


Thr Cys Glu Leu Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu 
        835                 840                 845             


Val Ala Lys Ser Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu 
    850                 855                 860                 


Ile Ser Asn Leu Ser Asn Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu 
865                 870                 875                 880 


Asp Ser Lys Asn Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys 
                885                 890                 895     


Tyr Phe Gly Ala Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr 
            900                 905                 910         


Lys Lys Asp Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu 
        915                 920                 925             


Glu Phe Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met 
    930                 935                 940                 


Lys Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn 
945                 950                 955                 960 


Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln 
                965                 970                 975     


Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr 
            980                 985                 990         


Leu Asp Phe Val Lys Asn Ser Asp  Gly His His Asn Thr  Ser Asn Phe 
        995                 1000                 1005             


Met Asn  Leu Phe Leu Asp Asn  Ile Ser Phe Trp Lys  Leu Phe Gly 
    1010                 1015                 1020             


Phe Glu  Asn Ile Asn Phe Val  Ile Asp Lys Tyr Phe  Thr Leu Val 
    1025                 1030                 1035             


Gly Lys  Thr Asn Leu Gly Tyr  Val Glu Phe Ile Cys  Asp Asn Asn 
    1040                 1045                 1050             


Lys Asn  Ile Asp Ile Tyr Phe  Gly Glu Trp Lys Thr  Ser Ser Ser 
    1055                 1060                 1065             


Lys Ser  Thr Ile Phe Ser Gly  Asn Gly Arg Asn Val  Val Val Glu 
    1070                 1075                 1080             


Pro Ile  Tyr Asn Pro Asp Thr  Gly Glu Asp Ile Ser  Thr Ser Leu 
    1085                 1090                 1095             


Asp Phe  Ser Tyr Glu Pro Leu  Tyr Gly Ile Asp Arg  Tyr Ile Asn 
    1100                 1105                 1110             


Lys Val  Leu Ile Ala Pro Asp  Leu Tyr Thr Ser Leu  Ile Asn Ile 
    1115                 1120                 1125             


Asn Thr  Asn Tyr Tyr Ser Asn  Glu Tyr Tyr Pro Glu  Ile Ile Val 
    1130                 1135                 1140             


Leu Asn  Pro Asn Thr Phe His  Lys Lys Val Asn Ile  Asn Leu Asp 
    1145                 1150                 1155             


Ser Ser  Ser Phe Glu Tyr Lys  Trp Ser Thr Glu Gly  Ser Asp Phe 
    1160                 1165                 1170             


Ile Leu  Val Arg Tyr Leu Glu  Glu Ser Asn Lys Lys  Ile Leu Gln 
    1175                 1180                 1185             


Lys Ile  Arg Ile Lys Gly Ile  Leu Ser Asn Thr Gln  Ser Phe Asn 
    1190                 1195                 1200             


Lys Met  Ser Ile Asp Phe Lys  Asp Ile Lys Lys Leu  Ser Leu Gly 
    1205                 1210                 1215             


Tyr Ile  Met Ser Asn Phe Lys  Ser Phe Asn Ser Glu  Asn Glu Leu 
    1220                 1225                 1230             


Asp Arg  Asp His Leu Gly Phe  Lys Ile Ile Asp Asn  Lys Thr Tyr 
    1235                 1240                 1245             


Tyr Tyr  Asp Glu Asp Ser Lys  Leu Val Lys Gly Leu  Ile Asn Ile 
    1250                 1255                 1260             


Asn Asn  Ser Leu Phe Tyr Phe  Asp Pro Ile Glu Phe  Asn Leu Val 
    1265                 1270                 1275             


Thr Gly  Trp Gln Thr Ile Asn  Gly Lys Lys Tyr Tyr  Phe Asp Ile 
    1280                 1285                 1290             


Asn Thr  Gly Ala Ala Leu Ile  Ser Tyr Lys Ile Ile  Asn Gly Lys 
    1295                 1300                 1305             


His Phe  Tyr Phe Asn Asn Asp  Gly Val Met Gln Leu  Gly Val Phe 
    1310                 1315                 1320             


Lys Gly  Pro Asp Gly Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr Gln 
    1325                 1330                 1335             


Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Val Tyr Gln  Ser Lys Phe 
    1340                 1345                 1350             


Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe Asp Asn  Asp Ser Lys 
    1355                 1360                 1365             


Ala Val  Thr Gly Trp Arg Ile  Ile Asn Asn Glu Lys  Tyr Tyr Phe 
    1370                 1375                 1380             


Asn Pro  Asn Asn Ala Ile Ala  Ala Val Gly Leu Gln  Val Ile Asp 
    1385                 1390                 1395             


Asn Asn  Lys Tyr Tyr Phe Asn  Pro Asp Thr Ala Ile  Ile Ser Lys 
    1400                 1405                 1410             


Gly Trp  Gln Thr Val Asn Gly  Ser Arg Tyr Tyr Phe  Asp Thr Asp 
    1415                 1420                 1425             


Thr Ala  Ile Ala Phe Asn Gly  Tyr Lys Thr Ile Asp  Gly Lys His 
    1430                 1435                 1440             


Phe Tyr  Phe Asp Ser Asp Cys  Val Val Lys Ile Gly  Val Phe Ser 
    1445                 1450                 1455             


Thr Ser  Asn Gly Phe Glu Tyr  Phe Ala Pro Ala Asn  Thr Tyr Asn 
    1460                 1465                 1470             


Asn Asn  Ile Glu Gly Gln Ala  Ile Val Tyr Gln Ser  Lys Phe Leu 
    1475                 1480                 1485             


Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Asp Asn Asn  Ser Lys Ala 
    1490                 1495                 1500             


Val Thr  Gly Trp Gln Thr Ile  Asp Ser Lys Lys Tyr  Tyr Phe Asn 
    1505                 1510                 1515             


Thr Asn  Thr Ala Glu Ala Ala  Thr Gly Trp Gln Thr  Ile Asp Gly 
    1520                 1525                 1530             


Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ala Glu Ala  Ala Thr Gly 
    1535                 1540                 1545             


Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr 
    1550                 1555                 1560             


Ala Ile  Ala Ser Thr Gly Tyr  Thr Ile Ile Asn Gly  Lys His Phe 
    1565                 1570                 1575             


Tyr Phe  Asn Thr Asp Gly Ile  Met Gln Ile Gly Val  Phe Lys Gly 
    1580                 1585                 1590             


Pro Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  Asp Ala Asn 
    1595                 1600                 1605             


Asn Ile  Glu Gly Gln Ala Ile  Leu Tyr Gln Asn Glu  Phe Leu Thr 
    1610                 1615                 1620             


Leu Asn  Gly Lys Lys Tyr Tyr  Phe Gly Ser Asp Ser  Lys Ala Val 
    1625                 1630                 1635             


Thr Gly  Trp Arg Ile Ile Asn  Asn Lys Lys Tyr Tyr  Phe Asn Pro 
    1640                 1645                 1650             


Asn Asn  Ala Ile Ala Ala Ile  His Leu Cys Thr Ile  Asn Asn Asp 
    1655                 1660                 1665             


Lys Tyr  Tyr Phe Ser Tyr Asp  Gly Ile Leu Gln Asn  Gly Tyr Ile 
    1670                 1675                 1680             


Thr Ile  Glu Arg Asn Asn Phe  Tyr Phe Asp Ala Asn  Asn Glu Ser 
    1685                 1690                 1695             


Lys Met  Val Thr Gly Val Phe  Lys Gly Pro Asn Gly  Phe Glu Tyr 
    1700                 1705                 1710             


Phe Ala  Pro Ala Asn Thr His  Asn Asn Asn Ile Glu  Gly Gln Ala 
    1715                 1720                 1725             


Ile Val  Tyr Gln Asn Lys Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr 
    1730                 1735                 1740             


Tyr Phe  Asp Asn Asp Ser Lys  Ala Val Thr Gly Trp  Gln Thr Ile 
    1745                 1750                 1755             


Asp Gly  Lys Lys Tyr Tyr Phe  Asn Leu Asn Thr Ala  Glu Ala Ala 
    1760                 1765                 1770             


Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Leu 
    1775                 1780                 1785             


Asn Thr  Ala Glu Ala Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys 
    1790                 1795                 1800             


Lys Tyr  Tyr Phe Asn Thr Asn  Thr Phe Ile Ala Ser  Thr Gly Tyr 
    1805                 1810                 1815             


Thr Ser  Ile Asn Gly Lys His  Phe Tyr Phe Asn Thr  Asp Gly Ile 
    1820                 1825                 1830             


Met Gln  Ile Gly Val Phe Lys  Gly Pro Asn Gly Phe  Glu Tyr Phe 
    1835                 1840                 1845             


Ala Pro  Ala Asn Thr His Asn  Asn Asn Ile Glu Gly  Gln Ala Ile 
    1850                 1855                 1860             


Leu Tyr  Gln Asn Lys Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr 
    1865                 1870                 1875             


Phe Gly  Ser Asp Ser Lys Ala  Val Thr Gly Leu Arg  Thr Ile Asp 
    1880                 1885                 1890             


Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr Ala Val  Ala Val Thr 
    1895                 1900                 1905             


Gly Trp  Gln Thr Ile Asn Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn 
    1910                 1915                 1920             


Thr Ser  Ile Ala Ser Thr Gly  Tyr Thr Ile Ile Ser  Gly Lys His 
    1925                 1930                 1935             


Phe Tyr  Phe Asn Thr Asp Gly  Ile Met Gln Ile Gly  Val Phe Lys 
    1940                 1945                 1950             


Gly Pro  Asp Gly Phe Glu Tyr  Phe Ala Pro Ala Asn  Thr Asp Ala 
    1955                 1960                 1965             


Asn Asn  Ile Glu Gly Gln Ala  Ile Arg Tyr Gln Asn  Arg Phe Leu 
    1970                 1975                 1980             


Tyr Leu  His Asp Asn Ile Tyr  Tyr Phe Gly Asn Asn  Ser Lys Ala 
    1985                 1990                 1995             


Ala Thr  Gly Trp Val Thr Ile  Asp Gly Asn Arg Tyr  Tyr Phe Glu 
    2000                 2005                 2010             


Pro Asn  Thr Ala Met Gly Ala  Asn Gly Tyr Lys Thr  Ile Asp Asn 
    2015                 2020                 2025             


Lys Asn  Phe Tyr Phe Arg Asn  Gly Leu Pro Gln Ile  Gly Val Phe 
    2030                 2035                 2040             


Lys Gly  Ser Asn Gly Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr Asp 
    2045                 2050                 2055             


Ala Asn  Asn Ile Glu Gly Gln  Ala Ile Arg Tyr Gln  Asn Arg Phe 
    2060                 2065                 2070             


Leu His  Leu Leu Gly Lys Ile  Tyr Tyr Phe Gly Asn  Asn Ser Lys 
    2075                 2080                 2085             


Ala Val  Thr Gly Trp Gln Thr  Ile Asn Gly Lys Val  Tyr Tyr Phe 
    2090                 2095                 2100             


Met Pro  Asp Thr Ala Met Ala  Ala Ala Gly Gly Leu  Phe Glu Ile 
    2105                 2110                 2115             


Asp Gly  Val Ile Tyr Phe Phe  Gly Val Asp Gly Val  Lys Ala Pro 
    2120                 2125                 2130             


Gly Ile  Tyr Gly 
    2135         


<210>  36
<211>  2116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  36

His His His His His His His His His Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Ser His Met Ala Ser Asp Lys Ile Ile His 
        35                  40                  45              


Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp Gly Ala 
    50                  55                  60                  


Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys Met Ile 
65                  70                  75                  80  


Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys Leu Thr 
                85                  90                  95      


Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro Lys Tyr 
            100                 105                 110         


Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly Glu Val 
        115                 120                 125             


Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys Glu Phe 
    130                 135                 140                 


Leu Asp Ala Asn Leu Ala Arg Ala Leu Val Pro Arg Gly Ser Val Thr 
145                 150                 155                 160 


Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro Phe Thr Met Ile 
                165                 170                 175     


Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile Asp 
            180                 185                 190         


Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser Ile 
        195                 200                 205             


Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro Asp 
    210                 215                 220                 


Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser Ile 
225                 230                 235                 240 


Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile Ile 
                245                 250                 255     


His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu Asn 
            260                 265                 270         


Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp Glu 
        275                 280                 285             


Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr Tyr 
    290                 295                 300                 


Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val Glu 
305                 310                 315                 320 


Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys Glu 
                325                 330                 335     


Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn Leu 
            340                 345                 350         


Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu Asn 
        355                 360                 365             


Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys Asp 
    370                 375                 380                 


Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala Gln 
385                 390                 395                 400 


Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu Val 
                405                 410                 415     


Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu Pro Thr 
            420                 425                 430         


Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp Gly Ile Asn 
        435                 440                 445             


Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His Asp Pro Leu Leu 
    450                 455                 460                 


Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala Ile Asn Met Ser 
465                 470                 475                 480 


Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly Ile Gly Ala Glu 
                485                 490                 495     


Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser Ala Gly Ile Pro 
            500                 505                 510         


Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys Ala Thr Ser Val 
        515                 520                 525             


Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu 
    530                 535                 540                 


Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile 
545                 550                 555                 560 


Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn 
                565                 570                 575     


Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile 
            580                 585                 590         


Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu 
        595                 600                 605             


Ser Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser 
    610                 615                 620                 


Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp 
625                 630                 635                 640 


Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr 
                645                 650                 655     


Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr Trp 
            660                 665                 670         


Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys Pro Val 
        675                 680                 685             


Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp Thr Arg Asn 
    690                 695                 700                 


Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg Asn Lys Leu Ser 
705                 710                 715                 720 


Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu Ser Ser 
                725                 730                 735     


Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp Asp Leu Trp Ile 
            740                 745                 750         


Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn Gly Thr 
        755                 760                 765             


Ile Lys Lys Gly Lys Leu Ile Lys Asp Val Leu Ser Lys Ile Asp Ile 
    770                 775                 780                 


Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly 
785                 790                 795                 800 


Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp 
                805                 810                 815     


Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr 
            820                 825                 830         


Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser 
        835                 840                 845             


Asn Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile 
    850                 855                 860                 


Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile 
865                 870                 875                 880 


Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser Lys 
                885                 890                 895     


Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn Ser Lys 
            900                 905                 910         


Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp Ile Asn 
        915                 920                 925             


Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser Ile 
    930                 935                 940                 


Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val Asn Gly 
945                 950                 955                 960 


Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val Lys 
                965                 970                 975     


Asn Ser Asp Gly His His Asn Thr Ser Asn Phe Met Asn Leu Phe Leu 
            980                 985                 990         


Asp Asn Ile Ser Phe Trp Lys Leu  Phe Gly Phe Glu Asn  Ile Asn Phe 
        995                 1000                 1005             


Val Ile  Asp Lys Tyr Phe Thr  Leu Val Gly Lys Thr  Asn Leu Gly 
    1010                 1015                 1020             


Tyr Val  Glu Phe Ile Cys Asp  Asn Asn Lys Asn Ile  Asp Ile Tyr 
    1025                 1030                 1035             


Phe Gly  Glu Trp Lys Thr Ser  Ser Ser Lys Ser Thr  Ile Phe Ser 
    1040                 1045                 1050             


Gly Asn  Gly Arg Asn Val Val  Val Glu Pro Ile Tyr  Asn Pro Asp 
    1055                 1060                 1065             


Thr Gly  Glu Asp Ile Ser Thr  Ser Leu Asp Phe Ser  Tyr Glu Pro 
    1070                 1075                 1080             


Leu Tyr  Gly Ile Asp Arg Tyr  Ile Asn Lys Val Leu  Ile Ala Pro 
    1085                 1090                 1095             


Asp Leu  Tyr Thr Ser Leu Ile  Asn Ile Asn Thr Asn  Tyr Tyr Ser 
    1100                 1105                 1110             


Asn Glu  Tyr Tyr Pro Glu Ile  Ile Val Leu Asn Pro  Asn Thr Phe 
    1115                 1120                 1125             


His Lys  Lys Val Asn Ile Asn  Leu Asp Ser Ser Ser  Phe Glu Tyr 
    1130                 1135                 1140             


Lys Trp  Ser Thr Glu Gly Ser  Asp Phe Ile Leu Val  Arg Tyr Leu 
    1145                 1150                 1155             


Glu Glu  Ser Asn Lys Lys Ile  Leu Gln Lys Ile Arg  Ile Lys Gly 
    1160                 1165                 1170             


Ile Leu  Ser Asn Thr Gln Ser  Phe Asn Lys Met Ser  Ile Asp Phe 
    1175                 1180                 1185             


Lys Asp  Ile Lys Lys Leu Ser  Leu Gly Tyr Ile Met  Ser Asn Phe 
    1190                 1195                 1200             


Lys Ser  Phe Asn Ser Glu Asn  Glu Leu Asp Arg Asp  His Leu Gly 
    1205                 1210                 1215             


Phe Lys  Ile Ile Asp Asn Lys  Thr Tyr Tyr Tyr Asp  Glu Asp Ser 
    1220                 1225                 1230             


Lys Leu  Val Lys Gly Leu Ile  Asn Ile Asn Asn Ser  Leu Phe Tyr 
    1235                 1240                 1245             


Phe Asp  Pro Ile Glu Phe Asn  Leu Val Thr Gly Trp  Gln Thr Ile 
    1250                 1255                 1260             


Asn Gly  Lys Lys Tyr Tyr Phe  Asp Ile Asn Thr Gly  Ala Ala Leu 
    1265                 1270                 1275             


Ile Ser  Tyr Lys Ile Ile Asn  Gly Lys His Phe Tyr  Phe Asn Asn 
    1280                 1285                 1290             


Asp Gly  Val Met Gln Leu Gly  Val Phe Lys Gly Pro  Asp Gly Phe 
    1295                 1300                 1305             


Glu Tyr  Phe Ala Pro Ala Asn  Thr Gln Asn Asn Asn  Ile Glu Gly 
    1310                 1315                 1320             


Gln Ala  Ile Val Tyr Gln Ser  Lys Phe Leu Thr Leu  Asn Gly Lys 
    1325                 1330                 1335             


Lys Tyr  Tyr Phe Asp Asn Asp  Ser Lys Ala Val Thr  Gly Trp Arg 
    1340                 1345                 1350             


Ile Ile  Asn Asn Glu Lys Tyr  Tyr Phe Asn Pro Asn  Asn Ala Ile 
    1355                 1360                 1365             


Ala Ala  Val Gly Leu Gln Val  Ile Asp Asn Asn Lys  Tyr Tyr Phe 
    1370                 1375                 1380             


Asn Pro  Asp Thr Ala Ile Ile  Ser Lys Gly Trp Gln  Thr Val Asn 
    1385                 1390                 1395             


Gly Ser  Arg Tyr Tyr Phe Asp  Thr Asp Thr Ala Ile  Ala Phe Asn 
    1400                 1405                 1410             


Gly Tyr  Lys Thr Ile Asp Gly  Lys His Phe Tyr Phe  Asp Ser Asp 
    1415                 1420                 1425             


Cys Val  Val Lys Ile Gly Val  Phe Ser Thr Ser Asn  Gly Phe Glu 
    1430                 1435                 1440             


Tyr Phe  Ala Pro Ala Asn Thr  Tyr Asn Asn Asn Ile  Glu Gly Gln 
    1445                 1450                 1455             


Ala Ile  Val Tyr Gln Ser Lys  Phe Leu Thr Leu Asn  Gly Lys Lys 
    1460                 1465                 1470             


Tyr Tyr  Phe Asp Asn Asn Ser  Lys Ala Val Thr Gly  Trp Gln Thr 
    1475                 1480                 1485             


Ile Asp  Ser Lys Lys Tyr Tyr  Phe Asn Thr Asn Thr  Ala Glu Ala 
    1490                 1495                 1500             


Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn 
    1505                 1510                 1515             


Thr Asn  Thr Ala Glu Ala Ala  Thr Gly Trp Gln Thr  Ile Asp Gly 
    1520                 1525                 1530             


Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ala Ile Ala  Ser Thr Gly 
    1535                 1540                 1545             


Tyr Thr  Ile Ile Asn Gly Lys  His Phe Tyr Phe Asn  Thr Asp Gly 
    1550                 1555                 1560             


Ile Met  Gln Ile Gly Val Phe  Lys Gly Pro Asn Gly  Phe Glu Tyr 
    1565                 1570                 1575             


Phe Ala  Pro Ala Asn Thr Asp  Ala Asn Asn Ile Glu  Gly Gln Ala 
    1580                 1585                 1590             


Ile Leu  Tyr Gln Asn Glu Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr 
    1595                 1600                 1605             


Tyr Phe  Gly Ser Asp Ser Lys  Ala Val Thr Gly Trp  Arg Ile Ile 
    1610                 1615                 1620             


Asn Asn  Lys Lys Tyr Tyr Phe  Asn Pro Asn Asn Ala  Ile Ala Ala 
    1625                 1630                 1635             


Ile His  Leu Cys Thr Ile Asn  Asn Asp Lys Tyr Tyr  Phe Ser Tyr 
    1640                 1645                 1650             


Asp Gly  Ile Leu Gln Asn Gly  Tyr Ile Thr Ile Glu  Arg Asn Asn 
    1655                 1660                 1665             


Phe Tyr  Phe Asp Ala Asn Asn  Glu Ser Lys Met Val  Thr Gly Val 
    1670                 1675                 1680             


Phe Lys  Gly Pro Asn Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr 
    1685                 1690                 1695             


His Asn  Asn Asn Ile Glu Gly  Gln Ala Ile Val Tyr  Gln Asn Lys 
    1700                 1705                 1710             


Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr Phe Asp  Asn Asp Ser 
    1715                 1720                 1725             


Lys Ala  Val Thr Gly Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr 
    1730                 1735                 1740             


Phe Asn  Leu Asn Thr Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile 
    1745                 1750                 1755             


Asp Gly  Lys Lys Tyr Tyr Phe  Asn Leu Asn Thr Ala  Glu Ala Ala 
    1760                 1765                 1770             


Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr 
    1775                 1780                 1785             


Asn Thr  Phe Ile Ala Ser Thr  Gly Tyr Thr Ser Ile  Asn Gly Lys 
    1790                 1795                 1800             


His Phe  Tyr Phe Asn Thr Asp  Gly Ile Met Gln Ile  Gly Val Phe 
    1805                 1810                 1815             


Lys Gly  Pro Asn Gly Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr His 
    1820                 1825                 1830             


Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Leu Tyr Gln  Asn Lys Phe 
    1835                 1840                 1845             


Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe Gly Ser  Asp Ser Lys 
    1850                 1855                 1860             


Ala Val  Thr Gly Leu Arg Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe 
    1865                 1870                 1875             


Asn Thr  Asn Thr Ala Val Ala  Val Thr Gly Trp Gln  Thr Ile Asn 
    1880                 1885                 1890             


Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr Ser Ile  Ala Ser Thr 
    1895                 1900                 1905             


Gly Tyr  Thr Ile Ile Ser Gly  Lys His Phe Tyr Phe  Asn Thr Asp 
    1910                 1915                 1920             


Gly Ile  Met Gln Ile Gly Val  Phe Lys Gly Pro Asp  Gly Phe Glu 
    1925                 1930                 1935             


Tyr Phe  Ala Pro Ala Asn Thr  Asp Ala Asn Asn Ile  Glu Gly Gln 
    1940                 1945                 1950             


Ala Ile  Arg Tyr Gln Asn Arg  Phe Leu Tyr Leu His  Asp Asn Ile 
    1955                 1960                 1965             


Tyr Tyr  Phe Gly Asn Asn Ser  Lys Ala Ala Thr Gly  Trp Val Thr 
    1970                 1975                 1980             


Ile Asp  Gly Asn Arg Tyr Tyr  Phe Glu Pro Asn Thr  Ala Met Gly 
    1985                 1990                 1995             


Ala Asn  Gly Tyr Lys Thr Ile  Asp Asn Lys Asn Phe  Tyr Phe Arg 
    2000                 2005                 2010             


Asn Gly  Leu Pro Gln Ile Gly  Val Phe Lys Gly Ser  Asn Gly Phe 
    2015                 2020                 2025             


Glu Tyr  Phe Ala Pro Ala Asn  Thr Asp Ala Asn Asn  Ile Glu Gly 
    2030                 2035                 2040             


Gln Ala  Ile Arg Tyr Gln Asn  Arg Phe Leu His Leu  Leu Gly Lys 
    2045                 2050                 2055             


Ile Tyr  Tyr Phe Gly Asn Asn  Ser Lys Ala Val Thr  Gly Trp Gln 
    2060                 2065                 2070             


Thr Ile  Asn Gly Lys Val Tyr  Tyr Phe Met Pro Asp  Thr Ala Met 
    2075                 2080                 2085             


Ala Ala  Ala Gly Gly Leu Phe  Glu Ile Asp Gly Val  Ile Tyr Phe 
    2090                 2095                 2100             


Phe Gly  Val Asp Gly Val Lys  Ala Pro Gly Ile Tyr  Gly 
    2105                 2110                 2115     


<210>  37
<211>  2123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  37

His His His His His His His His His His Gly Gly Ser Leu Ala Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Ala Gly Gly Ser His Met 
        35                  40                  45              


Ala Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
    50                  55                  60                  


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
65                  70                  75                  80  


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
                85                  90                  95      


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
            100                 105                 110         


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
        115                 120                 125             


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
    130                 135                 140                 


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Arg Ala Leu 
145                 150                 155                 160 


Val Pro Arg Gly Ser Val Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala 
                165                 170                 175     


Ala Ala Pro Phe Thr Met Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr 
            180                 185                 190         


Ile Phe Phe Asp Ser Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn 
        195                 200                 205             


Ile Pro Gly Leu Ala Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu 
    210                 215                 220                 


Asp Ala Ser Val Ser Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys 
225                 230                 235                 240 


Leu Asn Ile Glu Ser Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu 
                245                 250                 255     


Glu Pro Val Lys Asn Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp 
            260                 265                 270         


Glu Phe Asn Leu Leu Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys 
        275                 280                 285             


Lys Leu Asn Asn Leu Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile 
    290                 295                 300                 


Ser Lys Asn Asn Ser Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn 
305                 310                 315                 320 


Gly Glu Ser Val Tyr Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr 
                325                 330                 335     


Ser Glu His Ile Thr Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile 
            340                 345                 350         


Thr Asp Val Asn Gly Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr 
        355                 360                 365             


Ser Gln Val Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile 
    370                 375                 380                 


Asp Tyr Ser Ser Asn Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val 
385                 390                 395                 400 


Lys Val Gln Leu Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile 
                405                 410                 415     


Tyr Asp Ser Ile Gln Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp 
            420                 425                 430         


Thr Ile Asn Val Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser 
        435                 440                 445             


Thr Ile Leu Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu 
    450                 455                 460                 


Asp Glu His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly 
465                 470                 475                 480 


Val Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser 
                485                 490                 495     


Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala 
            500                 505                 510         


Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu 
        515                 520                 525             


His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His Leu Ser Glu 
    530                 535                 540                 


Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu Val 
545                 550                 555                 560 


Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser 
                565                 570                 575     


Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met Glu Gly Gly Ser Gly 
            580                 585                 590         


His Thr Val Thr Gly Asn Ile Asp His Phe Phe Ser Ser Pro Ser Ile 
        595                 600                 605             


Ser Ser His Ile Pro Ser Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu 
    610                 615                 620                 


Thr Glu Asn Leu Asp Phe Ser Lys Lys Ile Met Met Leu Pro Asn Ala 
625                 630                 635                 640 


Pro Ser Arg Val Phe Trp Trp Glu Thr Gly Ala Val Pro Gly Leu Arg 
                645                 650                 655     


Ser Leu Glu Asn Asp Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu 
            660                 665                 670         


Tyr Pro Gly Lys Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala 
        675                 680                 685             


Ile Thr Thr Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys 
    690                 695                 700                 


Leu Asp Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn 
705                 710                 715                 720 


Glu Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr 
                725                 730                 735     


Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu 
            740                 745                 750         


Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg Glu 
        755                 760                 765             


Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile Lys Asp 
    770                 775                 780                 


Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn 
785                 790                 795                 800 


Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile 
                805                 810                 815     


Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile 
            820                 825                 830         


Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn 
        835                 840                 845             


Tyr Leu Ile Ser Asn Leu Ser Asn Ile Ile Glu Lys Ile Asn Thr Leu 
    850                 855                 860                 


Gly Leu Asp Ser Lys Asn Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn 
865                 870                 875                 880 


Asn Lys Tyr Phe Gly Ala Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile 
                885                 890                 895     


His Tyr Lys Lys Asp Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser 
            900                 905                 910         


Thr Leu Glu Phe Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val 
        915                 920                 925             


Phe Met Lys Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp 
    930                 935                 940                 


Asn Asn Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys 
945                 950                 955                 960 


Asn Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser 
                965                 970                 975     


Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser 
            980                 985                 990         


Asn Phe Met Asn Leu Phe Leu Asp  Asn Ile Ser Phe Trp  Lys Leu Phe 
        995                 1000                 1005             


Gly Phe  Glu Asn Ile Asn Phe  Val Ile Asp Lys Tyr  Phe Thr Leu 
    1010                 1015                 1020             


Val Gly  Lys Thr Asn Leu Gly  Tyr Val Glu Phe Ile  Cys Asp Asn 
    1025                 1030                 1035             


Asn Lys  Asn Ile Asp Ile Tyr  Phe Gly Glu Trp Lys  Thr Ser Ser 
    1040                 1045                 1050             


Ser Lys  Ser Thr Ile Phe Ser  Gly Asn Gly Arg Asn  Val Val Val 
    1055                 1060                 1065             


Glu Pro  Ile Tyr Asn Pro Asp  Thr Gly Glu Asp Ile  Ser Thr Ser 
    1070                 1075                 1080             


Leu Asp  Phe Ser Tyr Glu Pro  Leu Tyr Gly Ile Asp  Arg Tyr Ile 
    1085                 1090                 1095             


Asn Lys  Val Leu Ile Ala Pro  Asp Leu Tyr Thr Ser  Leu Ile Asn 
    1100                 1105                 1110             


Ile Asn  Thr Asn Tyr Tyr Ser  Asn Glu Tyr Tyr Pro  Glu Ile Ile 
    1115                 1120                 1125             


Val Leu  Asn Pro Asn Thr Phe  His Lys Lys Val Asn  Ile Asn Leu 
    1130                 1135                 1140             


Asp Ser  Ser Ser Phe Glu Tyr  Lys Trp Ser Thr Glu  Gly Ser Asp 
    1145                 1150                 1155             


Phe Ile  Leu Val Arg Tyr Leu  Glu Glu Ser Asn Lys  Lys Ile Leu 
    1160                 1165                 1170             


Gln Lys  Ile Arg Ile Lys Gly  Ile Leu Ser Asn Thr  Gln Ser Phe 
    1175                 1180                 1185             


Asn Lys  Met Ser Ile Asp Phe  Lys Asp Ile Lys Lys  Leu Ser Leu 
    1190                 1195                 1200             


Gly Tyr  Ile Met Ser Asn Phe  Lys Ser Phe Asn Ser  Glu Asn Glu 
    1205                 1210                 1215             


Leu Asp  Arg Asp His Leu Gly  Phe Lys Ile Ile Asp  Asn Lys Thr 
    1220                 1225                 1230             


Tyr Tyr  Tyr Asp Glu Asp Ser  Lys Leu Val Lys Gly  Leu Ile Asn 
    1235                 1240                 1245             


Ile Asn  Asn Ser Leu Phe Tyr  Phe Asp Pro Ile Glu  Phe Asn Leu 
    1250                 1255                 1260             


Val Thr  Gly Trp Gln Thr Ile  Asn Gly Lys Lys Tyr  Tyr Phe Asp 
    1265                 1270                 1275             


Ile Asn  Thr Gly Ala Ala Leu  Ile Ser Tyr Lys Ile  Ile Asn Gly 
    1280                 1285                 1290             


Lys His  Phe Tyr Phe Asn Asn  Asp Gly Val Met Gln  Leu Gly Val 
    1295                 1300                 1305             


Phe Lys  Gly Pro Asp Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr 
    1310                 1315                 1320             


Gln Asn  Asn Asn Ile Glu Gly  Gln Ala Ile Val Tyr  Gln Ser Lys 
    1325                 1330                 1335             


Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr Phe Asp  Asn Asp Ser 
    1340                 1345                 1350             


Lys Ala  Val Thr Gly Trp Arg  Ile Ile Asn Asn Glu  Lys Tyr Tyr 
    1355                 1360                 1365             


Phe Asn  Pro Asn Asn Ala Ile  Ala Ala Val Gly Leu  Gln Val Ile 
    1370                 1375                 1380             


Asp Asn  Asn Lys Tyr Tyr Phe  Asn Pro Asp Thr Ala  Ile Ile Ser 
    1385                 1390                 1395             


Lys Gly  Trp Gln Thr Val Asn  Gly Ser Arg Tyr Tyr  Phe Asp Thr 
    1400                 1405                 1410             


Asp Thr  Ala Ile Ala Phe Asn  Gly Tyr Lys Thr Ile  Asp Gly Lys 
    1415                 1420                 1425             


His Phe  Tyr Phe Asp Ser Asp  Cys Val Val Lys Ile  Gly Val Phe 
    1430                 1435                 1440             


Ser Thr  Ser Asn Gly Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr Tyr 
    1445                 1450                 1455             


Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Val Tyr Gln  Ser Lys Phe 
    1460                 1465                 1470             


Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe Asp Asn  Asn Ser Lys 
    1475                 1480                 1485             


Ala Val  Thr Gly Trp Gln Thr  Ile Asp Ser Lys Lys  Tyr Tyr Phe 
    1490                 1495                 1500             


Asn Thr  Asn Thr Ala Glu Ala  Ala Thr Gly Trp Gln  Thr Ile Asp 
    1505                 1510                 1515             


Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr Ala Glu  Ala Ala Thr 
    1520                 1525                 1530             


Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn 
    1535                 1540                 1545             


Thr Ala  Ile Ala Ser Thr Gly  Tyr Thr Ile Ile Asn  Gly Lys His 
    1550                 1555                 1560             


Phe Tyr  Phe Asn Thr Asp Gly  Ile Met Gln Ile Gly  Val Phe Lys 
    1565                 1570                 1575             


Gly Pro  Asn Gly Phe Glu Tyr  Phe Ala Pro Ala Asn  Thr Asp Ala 
    1580                 1585                 1590             


Asn Asn  Ile Glu Gly Gln Ala  Ile Leu Tyr Gln Asn  Glu Phe Leu 
    1595                 1600                 1605             


Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Gly Ser Asp  Ser Lys Ala 
    1610                 1615                 1620             


Val Thr  Gly Trp Arg Ile Ile  Asn Asn Lys Lys Tyr  Tyr Phe Asn 
    1625                 1630                 1635             


Pro Asn  Asn Ala Ile Ala Ala  Ile His Leu Cys Thr  Ile Asn Asn 
    1640                 1645                 1650             


Asp Lys  Tyr Tyr Phe Ser Tyr  Asp Gly Ile Leu Gln  Asn Gly Tyr 
    1655                 1660                 1665             


Ile Thr  Ile Glu Arg Asn Asn  Phe Tyr Phe Asp Ala  Asn Asn Glu 
    1670                 1675                 1680             


Ser Lys  Met Val Thr Gly Val  Phe Lys Gly Pro Asn  Gly Phe Glu 
    1685                 1690                 1695             


Tyr Phe  Ala Pro Ala Asn Thr  His Asn Asn Asn Ile  Glu Gly Gln 
    1700                 1705                 1710             


Ala Ile  Val Tyr Gln Asn Lys  Phe Leu Thr Leu Asn  Gly Lys Lys 
    1715                 1720                 1725             


Tyr Tyr  Phe Asp Asn Asp Ser  Lys Ala Val Thr Gly  Trp Gln Thr 
    1730                 1735                 1740             


Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Leu Asn Thr  Ala Glu Ala 
    1745                 1750                 1755             


Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn 
    1760                 1765                 1770             


Leu Asn  Thr Ala Glu Ala Ala  Thr Gly Trp Gln Thr  Ile Asp Gly 
    1775                 1780                 1785             


Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Phe Ile Ala  Ser Thr Gly 
    1790                 1795                 1800             


Tyr Thr  Ser Ile Asn Gly Lys  His Phe Tyr Phe Asn  Thr Asp Gly 
    1805                 1810                 1815             


Ile Met  Gln Ile Gly Val Phe  Lys Gly Pro Asn Gly  Phe Glu Tyr 
    1820                 1825                 1830             


Phe Ala  Pro Ala Asn Thr His  Asn Asn Asn Ile Glu  Gly Gln Ala 
    1835                 1840                 1845             


Ile Leu  Tyr Gln Asn Lys Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr 
    1850                 1855                 1860             


Tyr Phe  Gly Ser Asp Ser Lys  Ala Val Thr Gly Leu  Arg Thr Ile 
    1865                 1870                 1875             


Asp Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn Thr Ala  Val Ala Val 
    1880                 1885                 1890             


Thr Gly  Trp Gln Thr Ile Asn  Gly Lys Lys Tyr Tyr  Phe Asn Thr 
    1895                 1900                 1905             


Asn Thr  Ser Ile Ala Ser Thr  Gly Tyr Thr Ile Ile  Ser Gly Lys 
    1910                 1915                 1920             


His Phe  Tyr Phe Asn Thr Asp  Gly Ile Met Gln Ile  Gly Val Phe 
    1925                 1930                 1935             


Lys Gly  Pro Asp Gly Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr Asp 
    1940                 1945                 1950             


Ala Asn  Asn Ile Glu Gly Gln  Ala Ile Arg Tyr Gln  Asn Arg Phe 
    1955                 1960                 1965             


Leu Tyr  Leu His Asp Asn Ile  Tyr Tyr Phe Gly Asn  Asn Ser Lys 
    1970                 1975                 1980             


Ala Ala  Thr Gly Trp Val Thr  Ile Asp Gly Asn Arg  Tyr Tyr Phe 
    1985                 1990                 1995             


Glu Pro  Asn Thr Ala Met Gly  Ala Asn Gly Tyr Lys  Thr Ile Asp 
    2000                 2005                 2010             


Asn Lys  Asn Phe Tyr Phe Arg  Asn Gly Leu Pro Gln  Ile Gly Val 
    2015                 2020                 2025             


Phe Lys  Gly Ser Asn Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr 
    2030                 2035                 2040             


Asp Ala  Asn Asn Ile Glu Gly  Gln Ala Ile Arg Tyr  Gln Asn Arg 
    2045                 2050                 2055             


Phe Leu  His Leu Leu Gly Lys  Ile Tyr Tyr Phe Gly  Asn Asn Ser 
    2060                 2065                 2070             


Lys Ala  Val Thr Gly Trp Gln  Thr Ile Asn Gly Lys  Val Tyr Tyr 
    2075                 2080                 2085             


Phe Met  Pro Asp Thr Ala Met  Ala Ala Ala Gly Gly  Leu Phe Glu 
    2090                 2095                 2100             


Ile Asp  Gly Val Ile Tyr Phe  Phe Gly Val Asp Gly  Val Lys Ala 
    2105                 2110                 2115             


Pro Gly  Ile Tyr Gly 
    2120             


<210>  38
<211>  2104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  38

His His His His His His Ser His Met Ala Ser Asp Lys Ile Ile His 
1               5                   10                  15      


Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp Gly Ala 
            20                  25                  30          


Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys Met Ile 
        35                  40                  45              


Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys Leu Thr 
    50                  55                  60                  


Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro Lys Tyr 
65                  70                  75                  80  


Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly Glu Val 
                85                  90                  95      


Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys Glu Phe 
            100                 105                 110         


Leu Asp Ala Asn Leu Ala Arg Ala Leu Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Ser Ala Ala Ala Pro 
145                 150                 155                 160 


Phe Thr Met Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe 
                165                 170                 175     


Asp Ser Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly 
            180                 185                 190         


Leu Ala Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser 
        195                 200                 205             


Val Ser Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile 
    210                 215                 220                 


Glu Ser Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val 
225                 230                 235                 240 


Lys Asn Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn 
                245                 250                 255     


Leu Leu Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn 
            260                 265                 270         


Asn Leu Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn 
        275                 280                 285             


Asn Ser Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser 
    290                 295                 300                 


Val Tyr Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His 
305                 310                 315                 320 


Ile Thr Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val 
                325                 330                 335     


Asn Gly Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val 
            340                 345                 350         


Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser 
        355                 360                 365             


Ser Asn Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln 
    370                 375                 380                 


Leu Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser 
385                 390                 395                 400 


Ile Gln Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn 
                405                 410                 415     


Val Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu 
            420                 425                 430         


Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His 
        435                 440                 445             


Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala 
    450                 455                 460                 


Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly 
465                 470                 475                 480 


Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser 
                485                 490                 495     


Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys 
            500                 505                 510         


Ala Thr Ser Val Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Lys 
        515                 520                 525             


Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp 
    530                 535                 540                 


Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu 
545                 550                 555                 560 


Gly Thr Cys Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val 
                565                 570                 575     


Thr Gly Asn Ile Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His 
            580                 585                 590         


Ile Pro Ser Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn 
        595                 600                 605             


Leu Asp Phe Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg 
    610                 615                 620                 


Val Phe Trp Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu 
625                 630                 635                 640 


Asn Asp Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly 
                645                 650                 655     


Lys Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr 
            660                 665                 670         


Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys 
        675                 680                 685             


Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg 
    690                 695                 700                 


Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu 
705                 710                 715                 720 


Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp 
                725                 730                 735     


Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile 
            740                 745                 750         


Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile Lys Asp Val Leu Ser 
        755                 760                 765             


Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile 
    770                 775                 780                 


Asp Phe Ser Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr 
785                 790                 795                 800 


Cys Glu Leu Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val 
                805                 810                 815     


Ala Lys Ser Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile 
            820                 825                 830         


Ser Asn Leu Ser Asn Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp 
        835                 840                 845             


Ser Lys Asn Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr 
    850                 855                 860                 


Phe Gly Ala Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys 
865                 870                 875                 880 


Lys Asp Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu 
                885                 890                 895     


Phe Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys 
            900                 905                 910         


Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr 
        915                 920                 925             


Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val 
    930                 935                 940                 


Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu 
945                 950                 955                 960 


Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser Asn Phe Met 
                965                 970                 975     


Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu Phe Gly Phe Glu 
            980                 985                 990         


Asn Ile Asn Phe Val Ile Asp Lys  Tyr Phe Thr Leu Val  Gly Lys Thr 
        995                 1000                 1005             


Asn Leu  Gly Tyr Val Glu Phe  Ile Cys Asp Asn Asn  Lys Asn Ile 
    1010                 1015                 1020             


Asp Ile  Tyr Phe Gly Glu Trp  Lys Thr Ser Ser Ser  Lys Ser Thr 
    1025                 1030                 1035             


Ile Phe  Ser Gly Asn Gly Arg  Asn Val Val Val Glu  Pro Ile Tyr 
    1040                 1045                 1050             


Asn Pro  Asp Thr Gly Glu Asp  Ile Ser Thr Ser Leu  Asp Phe Ser 
    1055                 1060                 1065             


Tyr Glu  Pro Leu Tyr Gly Ile  Asp Arg Tyr Ile Asn  Lys Val Leu 
    1070                 1075                 1080             


Ile Ala  Pro Asp Leu Tyr Thr  Ser Leu Ile Asn Ile  Asn Thr Asn 
    1085                 1090                 1095             


Tyr Tyr  Ser Asn Glu Tyr Tyr  Pro Glu Ile Ile Val  Leu Asn Pro 
    1100                 1105                 1110             


Asn Thr  Phe His Lys Lys Val  Asn Ile Asn Leu Asp  Ser Ser Ser 
    1115                 1120                 1125             


Phe Glu  Tyr Lys Trp Ser Thr  Glu Gly Ser Asp Phe  Ile Leu Val 
    1130                 1135                 1140             


Arg Tyr  Leu Glu Glu Ser Asn  Lys Lys Ile Leu Gln  Lys Ile Arg 
    1145                 1150                 1155             


Ile Lys  Gly Ile Leu Ser Asn  Thr Gln Ser Phe Asn  Lys Met Ser 
    1160                 1165                 1170             


Ile Asp  Phe Lys Asp Ile Lys  Lys Leu Ser Leu Gly  Tyr Ile Met 
    1175                 1180                 1185             


Ser Asn  Phe Lys Ser Phe Asn  Ser Glu Asn Glu Leu  Asp Arg Asp 
    1190                 1195                 1200             


His Leu  Gly Phe Lys Ile Ile  Asp Asn Lys Thr Tyr  Tyr Tyr Asp 
    1205                 1210                 1215             


Glu Asp  Ser Lys Leu Val Lys  Gly Leu Ile Asn Ile  Asn Asn Ser 
    1220                 1225                 1230             


Leu Phe  Tyr Phe Asp Pro Ile  Glu Phe Asn Leu Val  Thr Gly Trp 
    1235                 1240                 1245             


Gln Thr  Ile Asn Gly Lys Lys  Tyr Tyr Phe Asp Ile  Asn Thr Gly 
    1250                 1255                 1260             


Ala Ala  Leu Ile Ser Tyr Lys  Ile Ile Asn Gly Lys  His Phe Tyr 
    1265                 1270                 1275             


Phe Asn  Asn Asp Gly Val Met  Gln Leu Gly Val Phe  Lys Gly Pro 
    1280                 1285                 1290             


Asp Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn Thr Gln  Asn Asn Asn 
    1295                 1300                 1305             


Ile Glu  Gly Gln Ala Ile Val  Tyr Gln Ser Lys Phe  Leu Thr Leu 
    1310                 1315                 1320             


Asn Gly  Lys Lys Tyr Tyr Phe  Asp Asn Asp Ser Lys  Ala Val Thr 
    1325                 1330                 1335             


Gly Trp  Arg Ile Ile Asn Asn  Glu Lys Tyr Tyr Phe  Asn Pro Asn 
    1340                 1345                 1350             


Asn Ala  Ile Ala Ala Val Gly  Leu Gln Val Ile Asp  Asn Asn Lys 
    1355                 1360                 1365             


Tyr Tyr  Phe Asn Pro Asp Thr  Ala Ile Ile Ser Lys  Gly Trp Gln 
    1370                 1375                 1380             


Thr Val  Asn Gly Ser Arg Tyr  Tyr Phe Asp Thr Asp  Thr Ala Ile 
    1385                 1390                 1395             


Ala Phe  Asn Gly Tyr Lys Thr  Ile Asp Gly Lys His  Phe Tyr Phe 
    1400                 1405                 1410             


Asp Ser  Asp Cys Val Val Lys  Ile Gly Val Phe Ser  Thr Ser Asn 
    1415                 1420                 1425             


Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr Tyr Asn  Asn Asn Ile 
    1430                 1435                 1440             


Glu Gly  Gln Ala Ile Val Tyr  Gln Ser Lys Phe Leu  Thr Leu Asn 
    1445                 1450                 1455             


Gly Lys  Lys Tyr Tyr Phe Asp  Asn Asn Ser Lys Ala  Val Thr Gly 
    1460                 1465                 1470             


Trp Gln  Thr Ile Asp Ser Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr 
    1475                 1480                 1485             


Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr 
    1490                 1495                 1500             


Tyr Phe  Asn Thr Asn Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr 
    1505                 1510                 1515             


Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr Asn Thr  Ala Ile Ala 
    1520                 1525                 1530             


Ser Thr  Gly Tyr Thr Ile Ile  Asn Gly Lys His Phe  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Asp  Gly Ile Met Gln Ile  Gly Val Phe Lys Gly  Pro Asn Gly 
    1550                 1555                 1560             


Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr Asp Ala Asn  Asn Ile Glu 
    1565                 1570                 1575             


Gly Gln  Ala Ile Leu Tyr Gln  Asn Glu Phe Leu Thr  Leu Asn Gly 
    1580                 1585                 1590             


Lys Lys  Tyr Tyr Phe Gly Ser  Asp Ser Lys Ala Val  Thr Gly Trp 
    1595                 1600                 1605             


Arg Ile  Ile Asn Asn Lys Lys  Tyr Tyr Phe Asn Pro  Asn Asn Ala 
    1610                 1615                 1620             


Ile Ala  Ala Ile His Leu Cys  Thr Ile Asn Asn Asp  Lys Tyr Tyr 
    1625                 1630                 1635             


Phe Ser  Tyr Asp Gly Ile Leu  Gln Asn Gly Tyr Ile  Thr Ile Glu 
    1640                 1645                 1650             


Arg Asn  Asn Phe Tyr Phe Asp  Ala Asn Asn Glu Ser  Lys Met Val 
    1655                 1660                 1665             


Thr Gly  Val Phe Lys Gly Pro  Asn Gly Phe Glu Tyr  Phe Ala Pro 
    1670                 1675                 1680             


Ala Asn  Thr His Asn Asn Asn  Ile Glu Gly Gln Ala  Ile Val Tyr 
    1685                 1690                 1695             


Gln Asn  Lys Phe Leu Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Asp 
    1700                 1705                 1710             


Asn Asp  Ser Lys Ala Val Thr  Gly Trp Gln Thr Ile  Asp Gly Lys 
    1715                 1720                 1725             


Lys Tyr  Tyr Phe Asn Leu Asn  Thr Ala Glu Ala Ala  Thr Gly Trp 
    1730                 1735                 1740             


Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe Asn Leu  Asn Thr Ala 
    1745                 1750                 1755             


Glu Ala  Ala Thr Gly Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr 
    1760                 1765                 1770             


Phe Asn  Thr Asn Thr Phe Ile  Ala Ser Thr Gly Tyr  Thr Ser Ile 
    1775                 1780                 1785             


Asn Gly  Lys His Phe Tyr Phe  Asn Thr Asp Gly Ile  Met Gln Ile 
    1790                 1795                 1800             


Gly Val  Phe Lys Gly Pro Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala 
    1805                 1810                 1815             


Asn Thr  His Asn Asn Asn Ile  Glu Gly Gln Ala Ile  Leu Tyr Gln 
    1820                 1825                 1830             


Asn Lys  Phe Leu Thr Leu Asn  Gly Lys Lys Tyr Tyr  Phe Gly Ser 
    1835                 1840                 1845             


Asp Ser  Lys Ala Val Thr Gly  Leu Arg Thr Ile Asp  Gly Lys Lys 
    1850                 1855                 1860             


Tyr Tyr  Phe Asn Thr Asn Thr  Ala Val Ala Val Thr  Gly Trp Gln 
    1865                 1870                 1875             


Thr Ile  Asn Gly Lys Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ser Ile 
    1880                 1885                 1890             


Ala Ser  Thr Gly Tyr Thr Ile  Ile Ser Gly Lys His  Phe Tyr Phe 
    1895                 1900                 1905             


Asn Thr  Asp Gly Ile Met Gln  Ile Gly Val Phe Lys  Gly Pro Asp 
    1910                 1915                 1920             


Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr Asp Ala  Asn Asn Ile 
    1925                 1930                 1935             


Glu Gly  Gln Ala Ile Arg Tyr  Gln Asn Arg Phe Leu  Tyr Leu His 
    1940                 1945                 1950             


Asp Asn  Ile Tyr Tyr Phe Gly  Asn Asn Ser Lys Ala  Ala Thr Gly 
    1955                 1960                 1965             


Trp Val  Thr Ile Asp Gly Asn  Arg Tyr Tyr Phe Glu  Pro Asn Thr 
    1970                 1975                 1980             


Ala Met  Gly Ala Asn Gly Tyr  Lys Thr Ile Asp Asn  Lys Asn Phe 
    1985                 1990                 1995             


Tyr Phe  Arg Asn Gly Leu Pro  Gln Ile Gly Val Phe  Lys Gly Ser 
    2000                 2005                 2010             


Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn Thr Asp  Ala Asn Asn 
    2015                 2020                 2025             


Ile Glu  Gly Gln Ala Ile Arg  Tyr Gln Asn Arg Phe  Leu His Leu 
    2030                 2035                 2040             


Leu Gly  Lys Ile Tyr Tyr Phe  Gly Asn Asn Ser Lys  Ala Val Thr 
    2045                 2050                 2055             


Gly Trp  Gln Thr Ile Asn Gly  Lys Val Tyr Tyr Phe  Met Pro Asp 
    2060                 2065                 2070             


Thr Ala  Met Ala Ala Ala Gly  Gly Leu Phe Glu Ile  Asp Gly Val 
    2075                 2080                 2085             


Ile Tyr  Phe Phe Gly Val Asp  Gly Val Lys Ala Pro  Gly Ile Tyr 
    2090                 2095                 2100             


Gly 
    


<210>  39
<211>  2110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  39

His His His His His His Ser His Met Ala Ser Asp Lys Ile Ile His 
1               5                   10                  15      


Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp Gly Ala 
            20                  25                  30          


Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys Met Ile 
        35                  40                  45              


Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys Leu Thr 
    50                  55                  60                  


Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro Lys Tyr 
65                  70                  75                  80  


Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly Glu Val 
                85                  90                  95      


Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys Glu Phe 
            100                 105                 110         


Leu Asp Ala Asn Leu Ala Arg Ala Leu Leu Ala Glu Ala Ala Ala Lys 
        115                 120                 125             


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
    130                 135                 140                 


Ala Ala Ala Lys Ala Ala Ala Gly Gly Ser Leu Val Pro Arg Gly Ser 
145                 150                 155                 160 


Gly Ser Ala Ala Ala Pro Phe Thr Met Ile Met Ser Asp Leu Ser Ser 
                165                 170                 175     


Lys Glu Tyr Ile Phe Phe Asp Ser Ile Asp Asn Lys Leu Lys Ala Lys 
            180                 185                 190         


Ser Lys Asn Ile Pro Gly Leu Ala Ser Ile Ser Glu Asp Ile Lys Thr 
        195                 200                 205             


Leu Leu Leu Asp Ala Ser Val Ser Pro Asp Thr Lys Phe Ile Leu Asn 
    210                 215                 220                 


Asn Leu Lys Leu Asn Ile Glu Ser Ser Ile Gly Asp Tyr Ile Tyr Tyr 
225                 230                 235                 240 


Glu Lys Leu Glu Pro Val Lys Asn Ile Ile His Asn Ser Ile Asp Asp 
                245                 250                 255     


Leu Ile Asp Glu Phe Asn Leu Leu Glu Asn Val Ser Asp Glu Leu Tyr 
            260                 265                 270         


Glu Leu Lys Lys Leu Asn Asn Leu Asp Glu Lys Tyr Leu Ile Ser Phe 
        275                 280                 285             


Glu Asp Ile Ser Lys Asn Asn Ser Thr Tyr Ser Val Arg Phe Ile Asn 
    290                 295                 300                 


Lys Ser Asn Gly Glu Ser Val Tyr Val Glu Thr Glu Lys Glu Ile Phe 
305                 310                 315                 320 


Ser Lys Tyr Ser Glu His Ile Thr Lys Glu Ile Ser Thr Ile Lys Asn 
                325                 330                 335     


Ser Ile Ile Thr Asp Val Asn Gly Asn Leu Leu Asp Asn Ile Gln Leu 
            340                 345                 350         


Asp His Thr Ser Gln Val Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln 
        355                 360                 365             


Ser Leu Ile Asp Tyr Ser Ser Asn Lys Asp Val Leu Asn Asp Leu Ser 
    370                 375                 380                 


Thr Ser Val Lys Val Gln Leu Tyr Ala Gln Leu Phe Ser Thr Gly Leu 
385                 390                 395                 400 


Asn Thr Ile Tyr Asp Ser Ile Gln Leu Val Asn Leu Ile Ser Asn Ala 
                405                 410                 415     


Val Asn Asp Thr Ile Asn Val Leu Pro Thr Ile Thr Glu Gly Ile Pro 
            420                 425                 430         


Ile Val Ser Thr Ile Leu Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys 
        435                 440                 445             


Glu Leu Leu Asp Glu His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala 
    450                 455                 460                 


Lys Val Gly Val Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr 
465                 470                 475                 480 


Val Ala Ser Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu 
                485                 490                 495     


Pro Ile Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu 
            500                 505                 510         


Leu Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His 
        515                 520                 525             


Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys 
    530                 535                 540                 


Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn 
545                 550                 555                 560 


Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met Glu Gly 
                565                 570                 575     


Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe Phe Ser Ser 
            580                 585                 590         


Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile Tyr Ser Ala Ile 
        595                 600                 605             


Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys Lys Ile Met Met Leu 
    610                 615                 620                 


Pro Asn Ala Pro Ser Arg Val Phe Trp Trp Glu Thr Gly Ala Val Pro 
625                 630                 635                 640 


Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Arg Leu Leu Asp Ser Ile 
                645                 650                 655     


Arg Asp Leu Tyr Pro Gly Lys Phe Tyr Trp Arg Phe Tyr Ala Phe Phe 
            660                 665                 670         


Asp Tyr Ala Ile Thr Thr Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile 
        675                 680                 685             


Lys Ile Lys Leu Asp Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile 
    690                 695                 700                 


Thr Thr Asn Glu Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala 
705                 710                 715                 720 


Gly Gly Thr Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn 
                725                 730                 735     


Ile Asn Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu 
            740                 745                 750         


Val Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu 
        755                 760                 765             


Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile 
    770                 775                 780                 


Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys Asp 
785                 790                 795                 800 


Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser Leu Ile 
                805                 810                 815     


Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu Leu Ser Gly 
            820                 825                 830         


Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Ile Ile Glu Lys Ile 
        835                 840                 845             


Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala Tyr Asn Tyr Thr Asp 
    850                 855                 860                 


Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile Ser Lys Thr Ser Gln Lys 
865                 870                 875                 880 


Ser Ile Ile His Tyr Lys Lys Asp Ser Lys Asn Ile Leu Glu Phe Tyr 
                885                 890                 895     


Asn Asp Ser Thr Leu Glu Phe Asn Ser Lys Asp Phe Ile Ala Glu Asp 
            900                 905                 910         


Ile Asn Val Phe Met Lys Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr 
        915                 920                 925             


Tyr Val Asp Asn Asn Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu 
    930                 935                 940                 


Val Ser Lys Asn Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser 
945                 950                 955                 960 


Val Tyr Ser Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His 
                965                 970                 975     


Asn Thr Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp 
            980                 985                 990         


Lys Leu Phe Gly Phe Glu Asn Ile  Asn Phe Val Ile Asp  Lys Tyr Phe 
        995                 1000                 1005             


Thr Leu  Val Gly Lys Thr Asn  Leu Gly Tyr Val Glu  Phe Ile Cys 
    1010                 1015                 1020             


Asp Asn  Asn Lys Asn Ile Asp  Ile Tyr Phe Gly Glu  Trp Lys Thr 
    1025                 1030                 1035             


Ser Ser  Ser Lys Ser Thr Ile  Phe Ser Gly Asn Gly  Arg Asn Val 
    1040                 1045                 1050             


Val Val  Glu Pro Ile Tyr Asn  Pro Asp Thr Gly Glu  Asp Ile Ser 
    1055                 1060                 1065             


Thr Ser  Leu Asp Phe Ser Tyr  Glu Pro Leu Tyr Gly  Ile Asp Arg 
    1070                 1075                 1080             


Tyr Ile  Asn Lys Val Leu Ile  Ala Pro Asp Leu Tyr  Thr Ser Leu 
    1085                 1090                 1095             


Ile Asn  Ile Asn Thr Asn Tyr  Tyr Ser Asn Glu Tyr  Tyr Pro Glu 
    1100                 1105                 1110             


Ile Ile  Val Leu Asn Pro Asn  Thr Phe His Lys Lys  Val Asn Ile 
    1115                 1120                 1125             


Asn Leu  Asp Ser Ser Ser Phe  Glu Tyr Lys Trp Ser  Thr Glu Gly 
    1130                 1135                 1140             


Ser Asp  Phe Ile Leu Val Arg  Tyr Leu Glu Glu Ser  Asn Lys Lys 
    1145                 1150                 1155             


Ile Leu  Gln Lys Ile Arg Ile  Lys Gly Ile Leu Ser  Asn Thr Gln 
    1160                 1165                 1170             


Ser Phe  Asn Lys Met Ser Ile  Asp Phe Lys Asp Ile  Lys Lys Leu 
    1175                 1180                 1185             


Ser Leu  Gly Tyr Ile Met Ser  Asn Phe Lys Ser Phe  Asn Ser Glu 
    1190                 1195                 1200             


Asn Glu  Leu Asp Arg Asp His  Leu Gly Phe Lys Ile  Ile Asp Asn 
    1205                 1210                 1215             


Lys Thr  Tyr Tyr Tyr Asp Glu  Asp Ser Lys Leu Val  Lys Gly Leu 
    1220                 1225                 1230             


Ile Asn  Ile Asn Asn Ser Leu  Phe Tyr Phe Asp Pro  Ile Glu Phe 
    1235                 1240                 1245             


Asn Leu  Val Thr Gly Trp Gln  Thr Ile Asn Gly Lys  Lys Tyr Tyr 
    1250                 1255                 1260             


Phe Asp  Ile Asn Thr Gly Ala  Ala Leu Ile Ser Tyr  Lys Ile Ile 
    1265                 1270                 1275             


Asn Gly  Lys His Phe Tyr Phe  Asn Asn Asp Gly Val  Met Gln Leu 
    1280                 1285                 1290             


Gly Val  Phe Lys Gly Pro Asp  Gly Phe Glu Tyr Phe  Ala Pro Ala 
    1295                 1300                 1305             


Asn Thr  Gln Asn Asn Asn Ile  Glu Gly Gln Ala Ile  Val Tyr Gln 
    1310                 1315                 1320             


Ser Lys  Phe Leu Thr Leu Asn  Gly Lys Lys Tyr Tyr  Phe Asp Asn 
    1325                 1330                 1335             


Asp Ser  Lys Ala Val Thr Gly  Trp Arg Ile Ile Asn  Asn Glu Lys 
    1340                 1345                 1350             


Tyr Tyr  Phe Asn Pro Asn Asn  Ala Ile Ala Ala Val  Gly Leu Gln 
    1355                 1360                 1365             


Val Ile  Asp Asn Asn Lys Tyr  Tyr Phe Asn Pro Asp  Thr Ala Ile 
    1370                 1375                 1380             


Ile Ser  Lys Gly Trp Gln Thr  Val Asn Gly Ser Arg  Tyr Tyr Phe 
    1385                 1390                 1395             


Asp Thr  Asp Thr Ala Ile Ala  Phe Asn Gly Tyr Lys  Thr Ile Asp 
    1400                 1405                 1410             


Gly Lys  His Phe Tyr Phe Asp  Ser Asp Cys Val Val  Lys Ile Gly 
    1415                 1420                 1425             


Val Phe  Ser Thr Ser Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn 
    1430                 1435                 1440             


Thr Tyr  Asn Asn Asn Ile Glu  Gly Gln Ala Ile Val  Tyr Gln Ser 
    1445                 1450                 1455             


Lys Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr Tyr Phe  Asp Asn Asn 
    1460                 1465                 1470             


Ser Lys  Ala Val Thr Gly Trp  Gln Thr Ile Asp Ser  Lys Lys Tyr 
    1475                 1480                 1485             


Tyr Phe  Asn Thr Asn Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr 
    1490                 1495                 1500             


Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr Asn Thr  Ala Glu Ala 
    1505                 1510                 1515             


Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn 
    1520                 1525                 1530             


Thr Asn  Thr Ala Ile Ala Ser  Thr Gly Tyr Thr Ile  Ile Asn Gly 
    1535                 1540                 1545             


Lys His  Phe Tyr Phe Asn Thr  Asp Gly Ile Met Gln  Ile Gly Val 
    1550                 1555                 1560             


Phe Lys  Gly Pro Asn Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr 
    1565                 1570                 1575             


Asp Ala  Asn Asn Ile Glu Gly  Gln Ala Ile Leu Tyr  Gln Asn Glu 
    1580                 1585                 1590             


Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr Phe Gly  Ser Asp Ser 
    1595                 1600                 1605             


Lys Ala  Val Thr Gly Trp Arg  Ile Ile Asn Asn Lys  Lys Tyr Tyr 
    1610                 1615                 1620             


Phe Asn  Pro Asn Asn Ala Ile  Ala Ala Ile His Leu  Cys Thr Ile 
    1625                 1630                 1635             


Asn Asn  Asp Lys Tyr Tyr Phe  Ser Tyr Asp Gly Ile  Leu Gln Asn 
    1640                 1645                 1650             


Gly Tyr  Ile Thr Ile Glu Arg  Asn Asn Phe Tyr Phe  Asp Ala Asn 
    1655                 1660                 1665             


Asn Glu  Ser Lys Met Val Thr  Gly Val Phe Lys Gly  Pro Asn Gly 
    1670                 1675                 1680             


Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr His Asn Asn  Asn Ile Glu 
    1685                 1690                 1695             


Gly Gln  Ala Ile Val Tyr Gln  Asn Lys Phe Leu Thr  Leu Asn Gly 
    1700                 1705                 1710             


Lys Lys  Tyr Tyr Phe Asp Asn  Asp Ser Lys Ala Val  Thr Gly Trp 
    1715                 1720                 1725             


Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe Asn Leu  Asn Thr Ala 
    1730                 1735                 1740             


Glu Ala  Ala Thr Gly Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr 
    1745                 1750                 1755             


Phe Asn  Leu Asn Thr Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile 
    1760                 1765                 1770             


Asp Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn Thr Phe  Ile Ala Ser 
    1775                 1780                 1785             


Thr Gly  Tyr Thr Ser Ile Asn  Gly Lys His Phe Tyr  Phe Asn Thr 
    1790                 1795                 1800             


Asp Gly  Ile Met Gln Ile Gly  Val Phe Lys Gly Pro  Asn Gly Phe 
    1805                 1810                 1815             


Glu Tyr  Phe Ala Pro Ala Asn  Thr His Asn Asn Asn  Ile Glu Gly 
    1820                 1825                 1830             


Gln Ala  Ile Leu Tyr Gln Asn  Lys Phe Leu Thr Leu  Asn Gly Lys 
    1835                 1840                 1845             


Lys Tyr  Tyr Phe Gly Ser Asp  Ser Lys Ala Val Thr  Gly Leu Arg 
    1850                 1855                 1860             


Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Val 
    1865                 1870                 1875             


Ala Val  Thr Gly Trp Gln Thr  Ile Asn Gly Lys Lys  Tyr Tyr Phe 
    1880                 1885                 1890             


Asn Thr  Asn Thr Ser Ile Ala  Ser Thr Gly Tyr Thr  Ile Ile Ser 
    1895                 1900                 1905             


Gly Lys  His Phe Tyr Phe Asn  Thr Asp Gly Ile Met  Gln Ile Gly 
    1910                 1915                 1920             


Val Phe  Lys Gly Pro Asp Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn 
    1925                 1930                 1935             


Thr Asp  Ala Asn Asn Ile Glu  Gly Gln Ala Ile Arg  Tyr Gln Asn 
    1940                 1945                 1950             


Arg Phe  Leu Tyr Leu His Asp  Asn Ile Tyr Tyr Phe  Gly Asn Asn 
    1955                 1960                 1965             


Ser Lys  Ala Ala Thr Gly Trp  Val Thr Ile Asp Gly  Asn Arg Tyr 
    1970                 1975                 1980             


Tyr Phe  Glu Pro Asn Thr Ala  Met Gly Ala Asn Gly  Tyr Lys Thr 
    1985                 1990                 1995             


Ile Asp  Asn Lys Asn Phe Tyr  Phe Arg Asn Gly Leu  Pro Gln Ile 
    2000                 2005                 2010             


Gly Val  Phe Lys Gly Ser Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala 
    2015                 2020                 2025             


Asn Thr  Asp Ala Asn Asn Ile  Glu Gly Gln Ala Ile  Arg Tyr Gln 
    2030                 2035                 2040             


Asn Arg  Phe Leu His Leu Leu  Gly Lys Ile Tyr Tyr  Phe Gly Asn 
    2045                 2050                 2055             


Asn Ser  Lys Ala Val Thr Gly  Trp Gln Thr Ile Asn  Gly Lys Val 
    2060                 2065                 2070             


Tyr Tyr  Phe Met Pro Asp Thr  Ala Met Ala Ala Ala  Gly Gly Leu 
    2075                 2080                 2085             


Phe Glu  Ile Asp Gly Val Ile  Tyr Phe Phe Gly Val  Asp Gly Val 
    2090                 2095                 2100             


Lys Ala  Pro Gly Ile Tyr Gly  
    2105                 2110 


<210>  40
<211>  1755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  40

His His His His His His His His His Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Ser His Met Ala Ser Asp Lys Ile Ile His 
        35                  40                  45              


Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp Gly Ala 
    50                  55                  60                  


Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys Met Ile 
65                  70                  75                  80  


Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys Leu Thr 
                85                  90                  95      


Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro Lys Tyr 
            100                 105                 110         


Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly Glu Val 
        115                 120                 125             


Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys Glu Phe 
    130                 135                 140                 


Leu Asp Ala Asn Leu Ala Arg Ala Leu Val Pro Arg Gly Ser Val Thr 
145                 150                 155                 160 


Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro Phe Thr Met Glu 
                165                 170                 175     


Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu Val 
            180                 185                 190         


Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser 
        195                 200                 205             


Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met Glu Gly Gly Ser Gly 
    210                 215                 220                 


His Thr Val Thr Gly Asn Ile Asp His Phe Phe Ser Ser Pro Ser Ile 
225                 230                 235                 240 


Ser Ser His Ile Pro Ser Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu 
                245                 250                 255     


Thr Glu Asn Leu Asp Phe Ser Lys Lys Ile Met Met Leu Pro Asn Ala 
            260                 265                 270         


Pro Ser Arg Val Phe Trp Trp Glu Thr Gly Ala Val Pro Gly Leu Arg 
        275                 280                 285             


Ser Leu Glu Asn Asp Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu 
    290                 295                 300                 


Tyr Pro Gly Lys Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala 
305                 310                 315                 320 


Ile Thr Thr Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys 
                325                 330                 335     


Leu Asp Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn 
            340                 345                 350         


Glu Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr 
        355                 360                 365             


Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu 
    370                 375                 380                 


Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg Glu 
385                 390                 395                 400 


Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile Lys Asp 
                405                 410                 415     


Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn 
            420                 425                 430         


Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile 
        435                 440                 445             


Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile 
    450                 455                 460                 


Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn 
465                 470                 475                 480 


Tyr Leu Ile Ser Asn Leu Ser Asn Ile Ile Glu Lys Ile Asn Thr Leu 
                485                 490                 495     


Gly Leu Asp Ser Lys Asn Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn 
            500                 505                 510         


Asn Lys Tyr Phe Gly Ala Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile 
        515                 520                 525             


His Tyr Lys Lys Asp Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser 
    530                 535                 540                 


Thr Leu Glu Phe Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val 
545                 550                 555                 560 


Phe Met Lys Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp 
                565                 570                 575     


Asn Asn Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys 
            580                 585                 590         


Asn Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser 
        595                 600                 605             


Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser 
    610                 615                 620                 


Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu Phe 
625                 630                 635                 640 


Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr Leu Val 
                645                 650                 655     


Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp Asn Asn Lys 
            660                 665                 670         


Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser Ser Ser Lys Ser 
        675                 680                 685             


Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val Val Glu Pro Ile Tyr 
    690                 695                 700                 


Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr Ser Leu Asp Phe Ser Tyr 
705                 710                 715                 720 


Glu Pro Leu Tyr Gly Ile Asp Arg Tyr Ile Asn Lys Val Leu Ile Ala 
                725                 730                 735     


Pro Asp Leu Tyr Thr Ser Leu Ile Asn Ile Asn Thr Asn Tyr Tyr Ser 
            740                 745                 750         


Asn Glu Tyr Tyr Pro Glu Ile Ile Val Leu Asn Pro Asn Thr Phe His 
        755                 760                 765             


Lys Lys Val Asn Ile Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp 
    770                 775                 780                 


Ser Thr Glu Gly Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser 
785                 790                 795                 800 


Asn Lys Lys Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn 
                805                 810                 815     


Thr Gln Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys 
            820                 825                 830         


Leu Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu 
        835                 840                 845             


Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys 
    850                 855                 860                 


Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile Asn 
865                 870                 875                 880 


Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn Leu Val 
                885                 890                 895     


Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile Asn 
            900                 905                 910         


Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile Asn Gly Lys His Phe 
        915                 920                 925             


Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly Val Phe Lys Gly Pro 
    930                 935                 940                 


Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Gln Asn Asn Asn Ile 
945                 950                 955                 960 


Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly 
                965                 970                 975     


Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Arg 
            980                 985                 990         


Ile Ile Asn Asn Glu Lys Tyr Tyr  Phe Asn Pro Asn Asn  Ala Ile Ala 
        995                 1000                 1005             


Ala Val  Gly Leu Gln Val Ile  Asp Asn Asn Lys Tyr  Tyr Phe Asn 
    1010                 1015                 1020             


Pro Asp  Thr Ala Ile Ile Ser  Lys Gly Trp Gln Thr  Val Asn Gly 
    1025                 1030                 1035             


Ser Arg  Tyr Tyr Phe Asp Thr  Asp Thr Ala Ile Ala  Phe Asn Gly 
    1040                 1045                 1050             


Tyr Lys  Thr Ile Asp Gly Lys  His Phe Tyr Phe Asp  Ser Asp Cys 
    1055                 1060                 1065             


Val Val  Lys Ile Gly Val Phe  Ser Thr Ser Asn Gly  Phe Glu Tyr 
    1070                 1075                 1080             


Phe Ala  Pro Ala Asn Thr Tyr  Asn Asn Asn Ile Glu  Gly Gln Ala 
    1085                 1090                 1095             


Ile Val  Tyr Gln Ser Lys Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr 
    1100                 1105                 1110             


Tyr Phe  Asp Asn Asn Ser Lys  Ala Val Thr Gly Trp  Gln Thr Ile 
    1115                 1120                 1125             


Asp Ser  Lys Lys Tyr Tyr Phe  Asn Thr Asn Thr Ala  Glu Ala Ala 
    1130                 1135                 1140             


Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr 
    1145                 1150                 1155             


Asn Thr  Ala Glu Ala Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys 
    1160                 1165                 1170             


Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ala Ile Ala Ser  Thr Gly Tyr 
    1175                 1180                 1185             


Thr Ile  Ile Asn Gly Lys His  Phe Tyr Phe Asn Thr  Asp Gly Ile 
    1190                 1195                 1200             


Met Gln  Ile Gly Val Phe Lys  Gly Pro Asn Gly Phe  Glu Tyr Phe 
    1205                 1210                 1215             


Ala Pro  Ala Asn Thr Asp Ala  Asn Asn Ile Glu Gly  Gln Ala Ile 
    1220                 1225                 1230             


Leu Tyr  Gln Asn Glu Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr 
    1235                 1240                 1245             


Phe Gly  Ser Asp Ser Lys Ala  Val Thr Gly Trp Arg  Ile Ile Asn 
    1250                 1255                 1260             


Asn Lys  Lys Tyr Tyr Phe Asn  Pro Asn Asn Ala Ile  Ala Ala Ile 
    1265                 1270                 1275             


His Leu  Cys Thr Ile Asn Asn  Asp Lys Tyr Tyr Phe  Ser Tyr Asp 
    1280                 1285                 1290             


Gly Ile  Leu Gln Asn Gly Tyr  Ile Thr Ile Glu Arg  Asn Asn Phe 
    1295                 1300                 1305             


Tyr Phe  Asp Ala Asn Asn Glu  Ser Lys Met Val Thr  Gly Val Phe 
    1310                 1315                 1320             


Lys Gly  Pro Asn Gly Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr His 
    1325                 1330                 1335             


Asn Asn  Asn Ile Glu Gly Gln  Ala Ile Val Tyr Gln  Asn Lys Phe 
    1340                 1345                 1350             


Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe Asp Asn  Asp Ser Lys 
    1355                 1360                 1365             


Ala Val  Thr Gly Trp Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe 
    1370                 1375                 1380             


Asn Leu  Asn Thr Ala Glu Ala  Ala Thr Gly Trp Gln  Thr Ile Asp 
    1385                 1390                 1395             


Gly Lys  Lys Tyr Tyr Phe Asn  Leu Asn Thr Ala Glu  Ala Ala Thr 
    1400                 1405                 1410             


Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn 
    1415                 1420                 1425             


Thr Phe  Ile Ala Ser Thr Gly  Tyr Thr Ser Ile Asn  Gly Lys His 
    1430                 1435                 1440             


Phe Tyr  Phe Asn Thr Asp Gly  Ile Met Gln Ile Gly  Val Phe Lys 
    1445                 1450                 1455             


Gly Pro  Asn Gly Phe Glu Tyr  Phe Ala Pro Ala Asn  Thr His Asn 
    1460                 1465                 1470             


Asn Asn  Ile Glu Gly Gln Ala  Ile Leu Tyr Gln Asn  Lys Phe Leu 
    1475                 1480                 1485             


Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Gly Ser Asp  Ser Lys Ala 
    1490                 1495                 1500             


Val Thr  Gly Leu Arg Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn 
    1505                 1510                 1515             


Thr Asn  Thr Ala Val Ala Val  Thr Gly Trp Gln Thr  Ile Asn Gly 
    1520                 1525                 1530             


Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ser Ile Ala  Ser Thr Gly 
    1535                 1540                 1545             


Tyr Thr  Ile Ile Ser Gly Lys  His Phe Tyr Phe Asn  Thr Asp Gly 
    1550                 1555                 1560             


Ile Met  Gln Ile Gly Val Phe  Lys Gly Pro Asp Gly  Phe Glu Tyr 
    1565                 1570                 1575             


Phe Ala  Pro Ala Asn Thr Asp  Ala Asn Asn Ile Glu  Gly Gln Ala 
    1580                 1585                 1590             


Ile Arg  Tyr Gln Asn Arg Phe  Leu Tyr Leu His Asp  Asn Ile Tyr 
    1595                 1600                 1605             


Tyr Phe  Gly Asn Asn Ser Lys  Ala Ala Thr Gly Trp  Val Thr Ile 
    1610                 1615                 1620             


Asp Gly  Asn Arg Tyr Tyr Phe  Glu Pro Asn Thr Ala  Met Gly Ala 
    1625                 1630                 1635             


Asn Gly  Tyr Lys Thr Ile Asp  Asn Lys Asn Phe Tyr  Phe Arg Asn 
    1640                 1645                 1650             


Gly Leu  Pro Gln Ile Gly Val  Phe Lys Gly Ser Asn  Gly Phe Glu 
    1655                 1660                 1665             


Tyr Phe  Ala Pro Ala Asn Thr  Asp Ala Asn Asn Ile  Glu Gly Gln 
    1670                 1675                 1680             


Ala Ile  Arg Tyr Gln Asn Arg  Phe Leu His Leu Leu  Gly Lys Ile 
    1685                 1690                 1695             


Tyr Tyr  Phe Gly Asn Asn Ser  Lys Ala Val Thr Gly  Trp Gln Thr 
    1700                 1705                 1710             


Ile Asn  Gly Lys Val Tyr Tyr  Phe Met Pro Asp Thr  Ala Met Ala 
    1715                 1720                 1725             


Ala Ala  Gly Gly Leu Phe Glu  Ile Asp Gly Val Ile  Tyr Phe Phe 
    1730                 1735                 1740             


Gly Val  Asp Gly Val Lys Ala  Pro Gly Ile Tyr Gly  
    1745                 1750                 1755 


<210>  41
<211>  1762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  41

His His His His His His His His His His Gly Gly Ser Leu Ala Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Ala Gly Gly Ser His Met 
        35                  40                  45              


Ala Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
    50                  55                  60                  


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
65                  70                  75                  80  


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
                85                  90                  95      


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
            100                 105                 110         


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
        115                 120                 125             


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
    130                 135                 140                 


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Arg Ala Leu 
145                 150                 155                 160 


Val Pro Arg Gly Ser Val Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala 
                165                 170                 175     


Ala Ala Pro Phe Thr Met Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr 
            180                 185                 190         


Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu 
        195                 200                 205             


Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu 
    210                 215                 220                 


Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His 
225                 230                 235                 240 


Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile 
                245                 250                 255     


Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys Lys 
            260                 265                 270         


Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp Glu Thr 
        275                 280                 285             


Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Arg Leu 
    290                 295                 300                 


Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr Trp Arg Phe 
305                 310                 315                 320 


Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys Pro Val Tyr Glu 
                325                 330                 335     


Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp Thr Arg Asn Phe Ile 
            340                 345                 350         


Met Pro Thr Ile Thr Thr Asn Glu Ile Arg Asn Lys Leu Ser Tyr Ser 
        355                 360                 365             


Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu Ser Ser Tyr Pro 
    370                 375                 380                 


Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn 
385                 390                 395                 400 


Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys 
                405                 410                 415     


Lys Gly Lys Leu Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys 
            420                 425                 430         


Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile 
        435                 440                 445             


Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys 
    450                 455                 460                 


Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu 
465                 470                 475                 480 


Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Ile 
                485                 490                 495     


Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala Tyr 
            500                 505                 510         


Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile Ser Lys 
        515                 520                 525             


Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser Lys Asn Ile 
    530                 535                 540                 


Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn Ser Lys Asp Phe 
545                 550                 555                 560 


Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp Ile Asn Thr Ile 
                565                 570                 575     


Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser Ile Asp Phe 
            580                 585                 590         


Ser Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val Asn Gly Leu Tyr 
        595                 600                 605             


Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val Lys Asn Ser 
    610                 615                 620                 


Asp Gly His His Asn Thr Ser Asn Phe Met Asn Leu Phe Leu Asp Asn 
625                 630                 635                 640 


Ile Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile 
                645                 650                 655     


Asp Lys Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu 
            660                 665                 670         


Phe Ile Cys Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp 
        675                 680                 685             


Lys Thr Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn 
    690                 695                 700                 


Val Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser 
705                 710                 715                 720 


Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr 
                725                 730                 735     


Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile Asn 
            740                 745                 750         


Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile Ile Val 
        755                 760                 765             


Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn Leu Asp Ser 
    770                 775                 780                 


Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser Asp Phe Ile Leu 
785                 790                 795                 800 


Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu Gln Lys Ile Arg 
                805                 810                 815     


Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser Phe Asn Lys Met Ser Ile 
            820                 825                 830         


Asp Phe Lys Asp Ile Lys Lys Leu Ser Leu Gly Tyr Ile Met Ser Asn 
        835                 840                 845             


Phe Lys Ser Phe Asn Ser Glu Asn Glu Leu Asp Arg Asp His Leu Gly 
    850                 855                 860                 


Phe Lys Ile Ile Asp Asn Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys 
865                 870                 875                 880 


Leu Val Lys Gly Leu Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp 
                885                 890                 895     


Pro Ile Glu Phe Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys 
            900                 905                 910         


Lys Tyr Tyr Phe Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys 
        915                 920                 925             


Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln 
    930                 935                 940                 


Leu Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala 
945                 950                 955                 960 


Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser 
                965                 970                 975     


Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser 
            980                 985                 990         


Lys Ala Val Thr Gly Trp Arg Ile  Ile Asn Asn Glu Lys  Tyr Tyr Phe 
        995                 1000                 1005             


Asn Pro  Asn Asn Ala Ile Ala  Ala Val Gly Leu Gln  Val Ile Asp 
    1010                 1015                 1020             


Asn Asn  Lys Tyr Tyr Phe Asn  Pro Asp Thr Ala Ile  Ile Ser Lys 
    1025                 1030                 1035             


Gly Trp  Gln Thr Val Asn Gly  Ser Arg Tyr Tyr Phe  Asp Thr Asp 
    1040                 1045                 1050             


Thr Ala  Ile Ala Phe Asn Gly  Tyr Lys Thr Ile Asp  Gly Lys His 
    1055                 1060                 1065             


Phe Tyr  Phe Asp Ser Asp Cys  Val Val Lys Ile Gly  Val Phe Ser 
    1070                 1075                 1080             


Thr Ser  Asn Gly Phe Glu Tyr  Phe Ala Pro Ala Asn  Thr Tyr Asn 
    1085                 1090                 1095             


Asn Asn  Ile Glu Gly Gln Ala  Ile Val Tyr Gln Ser  Lys Phe Leu 
    1100                 1105                 1110             


Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Asp Asn Asn  Ser Lys Ala 
    1115                 1120                 1125             


Val Thr  Gly Trp Gln Thr Ile  Asp Ser Lys Lys Tyr  Tyr Phe Asn 
    1130                 1135                 1140             


Thr Asn  Thr Ala Glu Ala Ala  Thr Gly Trp Gln Thr  Ile Asp Gly 
    1145                 1150                 1155             


Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ala Glu Ala  Ala Thr Gly 
    1160                 1165                 1170             


Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr 
    1175                 1180                 1185             


Ala Ile  Ala Ser Thr Gly Tyr  Thr Ile Ile Asn Gly  Lys His Phe 
    1190                 1195                 1200             


Tyr Phe  Asn Thr Asp Gly Ile  Met Gln Ile Gly Val  Phe Lys Gly 
    1205                 1210                 1215             


Pro Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  Asp Ala Asn 
    1220                 1225                 1230             


Asn Ile  Glu Gly Gln Ala Ile  Leu Tyr Gln Asn Glu  Phe Leu Thr 
    1235                 1240                 1245             


Leu Asn  Gly Lys Lys Tyr Tyr  Phe Gly Ser Asp Ser  Lys Ala Val 
    1250                 1255                 1260             


Thr Gly  Trp Arg Ile Ile Asn  Asn Lys Lys Tyr Tyr  Phe Asn Pro 
    1265                 1270                 1275             


Asn Asn  Ala Ile Ala Ala Ile  His Leu Cys Thr Ile  Asn Asn Asp 
    1280                 1285                 1290             


Lys Tyr  Tyr Phe Ser Tyr Asp  Gly Ile Leu Gln Asn  Gly Tyr Ile 
    1295                 1300                 1305             


Thr Ile  Glu Arg Asn Asn Phe  Tyr Phe Asp Ala Asn  Asn Glu Ser 
    1310                 1315                 1320             


Lys Met  Val Thr Gly Val Phe  Lys Gly Pro Asn Gly  Phe Glu Tyr 
    1325                 1330                 1335             


Phe Ala  Pro Ala Asn Thr His  Asn Asn Asn Ile Glu  Gly Gln Ala 
    1340                 1345                 1350             


Ile Val  Tyr Gln Asn Lys Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr 
    1355                 1360                 1365             


Tyr Phe  Asp Asn Asp Ser Lys  Ala Val Thr Gly Trp  Gln Thr Ile 
    1370                 1375                 1380             


Asp Gly  Lys Lys Tyr Tyr Phe  Asn Leu Asn Thr Ala  Glu Ala Ala 
    1385                 1390                 1395             


Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Leu 
    1400                 1405                 1410             


Asn Thr  Ala Glu Ala Ala Thr  Gly Trp Gln Thr Ile  Asp Gly Lys 
    1415                 1420                 1425             


Lys Tyr  Tyr Phe Asn Thr Asn  Thr Phe Ile Ala Ser  Thr Gly Tyr 
    1430                 1435                 1440             


Thr Ser  Ile Asn Gly Lys His  Phe Tyr Phe Asn Thr  Asp Gly Ile 
    1445                 1450                 1455             


Met Gln  Ile Gly Val Phe Lys  Gly Pro Asn Gly Phe  Glu Tyr Phe 
    1460                 1465                 1470             


Ala Pro  Ala Asn Thr His Asn  Asn Asn Ile Glu Gly  Gln Ala Ile 
    1475                 1480                 1485             


Leu Tyr  Gln Asn Lys Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr 
    1490                 1495                 1500             


Phe Gly  Ser Asp Ser Lys Ala  Val Thr Gly Leu Arg  Thr Ile Asp 
    1505                 1510                 1515             


Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr Ala Val  Ala Val Thr 
    1520                 1525                 1530             


Gly Trp  Gln Thr Ile Asn Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn 
    1535                 1540                 1545             


Thr Ser  Ile Ala Ser Thr Gly  Tyr Thr Ile Ile Ser  Gly Lys His 
    1550                 1555                 1560             


Phe Tyr  Phe Asn Thr Asp Gly  Ile Met Gln Ile Gly  Val Phe Lys 
    1565                 1570                 1575             


Gly Pro  Asp Gly Phe Glu Tyr  Phe Ala Pro Ala Asn  Thr Asp Ala 
    1580                 1585                 1590             


Asn Asn  Ile Glu Gly Gln Ala  Ile Arg Tyr Gln Asn  Arg Phe Leu 
    1595                 1600                 1605             


Tyr Leu  His Asp Asn Ile Tyr  Tyr Phe Gly Asn Asn  Ser Lys Ala 
    1610                 1615                 1620             


Ala Thr  Gly Trp Val Thr Ile  Asp Gly Asn Arg Tyr  Tyr Phe Glu 
    1625                 1630                 1635             


Pro Asn  Thr Ala Met Gly Ala  Asn Gly Tyr Lys Thr  Ile Asp Asn 
    1640                 1645                 1650             


Lys Asn  Phe Tyr Phe Arg Asn  Gly Leu Pro Gln Ile  Gly Val Phe 
    1655                 1660                 1665             


Lys Gly  Ser Asn Gly Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr Asp 
    1670                 1675                 1680             


Ala Asn  Asn Ile Glu Gly Gln  Ala Ile Arg Tyr Gln  Asn Arg Phe 
    1685                 1690                 1695             


Leu His  Leu Leu Gly Lys Ile  Tyr Tyr Phe Gly Asn  Asn Ser Lys 
    1700                 1705                 1710             


Ala Val  Thr Gly Trp Gln Thr  Ile Asn Gly Lys Val  Tyr Tyr Phe 
    1715                 1720                 1725             


Met Pro  Asp Thr Ala Met Ala  Ala Ala Gly Gly Leu  Phe Glu Ile 
    1730                 1735                 1740             


Asp Gly  Val Ile Tyr Phe Phe  Gly Val Asp Gly Val  Lys Ala Pro 
    1745                 1750                 1755             


Gly Ile  Tyr Gly 
    1760         


<210>  42
<211>  1743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  42

His His His His His His Ser His Met Ala Ser Asp Lys Ile Ile His 
1               5                   10                  15      


Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp Gly Ala 
            20                  25                  30          


Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys Met Ile 
        35                  40                  45              


Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys Leu Thr 
    50                  55                  60                  


Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro Lys Tyr 
65                  70                  75                  80  


Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly Glu Val 
                85                  90                  95      


Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys Glu Phe 
            100                 105                 110         


Leu Asp Ala Asn Leu Ala Arg Ala Leu Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Ser Ala Ala Ala Pro 
145                 150                 155                 160 


Phe Thr Met Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp 
                165                 170                 175     


Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe 
            180                 185                 190         


Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met Glu 
        195                 200                 205             


Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe Phe Ser 
    210                 215                 220                 


Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile Tyr Ser Ala 
225                 230                 235                 240 


Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys Lys Ile Met Met 
                245                 250                 255     


Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp Glu Thr Gly Ala Val 
            260                 265                 270         


Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Arg Leu Leu Asp Ser 
        275                 280                 285             


Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr Trp Arg Phe Tyr Ala Phe 
    290                 295                 300                 


Phe Asp Tyr Ala Ile Thr Thr Leu Lys Pro Val Tyr Glu Asp Thr Asn 
305                 310                 315                 320 


Ile Lys Ile Lys Leu Asp Lys Asp Thr Arg Asn Phe Ile Met Pro Thr 
                325                 330                 335     


Ile Thr Thr Asn Glu Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly 
            340                 345                 350         


Ala Gly Gly Thr Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr 
        355                 360                 365             


Asn Ile Asn Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn 
    370                 375                 380                 


Glu Val Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys 
385                 390                 395                 400 


Leu Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu 
                405                 410                 415     


Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys 
            420                 425                 430         


Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser Leu 
        435                 440                 445             


Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu Leu Ser 
    450                 455                 460                 


Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Ile Ile Glu Lys 
465                 470                 475                 480 


Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala Tyr Asn Tyr Thr 
                485                 490                 495     


Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile Ser Lys Thr Ser Gln 
            500                 505                 510         


Lys Ser Ile Ile His Tyr Lys Lys Asp Ser Lys Asn Ile Leu Glu Phe 
        515                 520                 525             


Tyr Asn Asp Ser Thr Leu Glu Phe Asn Ser Lys Asp Phe Ile Ala Glu 
    530                 535                 540                 


Asp Ile Asn Val Phe Met Lys Asp Asp Ile Asn Thr Ile Thr Gly Lys 
545                 550                 555                 560 


Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser 
                565                 570                 575     


Leu Val Ser Lys Asn Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu 
            580                 585                 590         


Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His 
        595                 600                 605             


His Asn Thr Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe 
    610                 615                 620                 


Trp Lys Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr 
625                 630                 635                 640 


Phe Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys 
                645                 650                 655     


Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser 
            660                 665                 670         


Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val Val 
        675                 680                 685             


Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr Ser Leu 
    690                 695                 700                 


Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr Ile Asn Lys 
705                 710                 715                 720 


Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile Asn Ile Asn Thr 
                725                 730                 735     


Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile Ile Val Leu Asn Pro 
            740                 745                 750         


Asn Thr Phe His Lys Lys Val Asn Ile Asn Leu Asp Ser Ser Ser Phe 
        755                 760                 765             


Glu Tyr Lys Trp Ser Thr Glu Gly Ser Asp Phe Ile Leu Val Arg Tyr 
    770                 775                 780                 


Leu Glu Glu Ser Asn Lys Lys Ile Leu Gln Lys Ile Arg Ile Lys Gly 
785                 790                 795                 800 


Ile Leu Ser Asn Thr Gln Ser Phe Asn Lys Met Ser Ile Asp Phe Lys 
                805                 810                 815     


Asp Ile Lys Lys Leu Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser 
            820                 825                 830         


Phe Asn Ser Glu Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile 
        835                 840                 845             


Ile Asp Asn Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys 
    850                 855                 860                 


Gly Leu Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu 
865                 870                 875                 880 


Phe Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr 
                885                 890                 895     


Phe Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile Asn 
            900                 905                 910         


Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly Val 
        915                 920                 925             


Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Gln 
    930                 935                 940                 


Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu 
945                 950                 955                 960 


Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val 
                965                 970                 975     


Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr Tyr Phe Asn Pro Asn 
            980                 985                 990         


Asn Ala Ile Ala Ala Val Gly Leu  Gln Val Ile Asp Asn  Asn Lys Tyr 
        995                 1000                 1005             


Tyr Phe  Asn Pro Asp Thr Ala  Ile Ile Ser Lys Gly  Trp Gln Thr 
    1010                 1015                 1020             


Val Asn  Gly Ser Arg Tyr Tyr  Phe Asp Thr Asp Thr  Ala Ile Ala 
    1025                 1030                 1035             


Phe Asn  Gly Tyr Lys Thr Ile  Asp Gly Lys His Phe  Tyr Phe Asp 
    1040                 1045                 1050             


Ser Asp  Cys Val Val Lys Ile  Gly Val Phe Ser Thr  Ser Asn Gly 
    1055                 1060                 1065             


Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr Tyr Asn Asn  Asn Ile Glu 
    1070                 1075                 1080             


Gly Gln  Ala Ile Val Tyr Gln  Ser Lys Phe Leu Thr  Leu Asn Gly 
    1085                 1090                 1095             


Lys Lys  Tyr Tyr Phe Asp Asn  Asn Ser Lys Ala Val  Thr Gly Trp 
    1100                 1105                 1110             


Gln Thr  Ile Asp Ser Lys Lys  Tyr Tyr Phe Asn Thr  Asn Thr Ala 
    1115                 1120                 1125             


Glu Ala  Ala Thr Gly Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr 
    1130                 1135                 1140             


Phe Asn  Thr Asn Thr Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile 
    1145                 1150                 1155             


Asp Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn Thr Ala  Ile Ala Ser 
    1160                 1165                 1170             


Thr Gly  Tyr Thr Ile Ile Asn  Gly Lys His Phe Tyr  Phe Asn Thr 
    1175                 1180                 1185             


Asp Gly  Ile Met Gln Ile Gly  Val Phe Lys Gly Pro  Asn Gly Phe 
    1190                 1195                 1200             


Glu Tyr  Phe Ala Pro Ala Asn  Thr Asp Ala Asn Asn  Ile Glu Gly 
    1205                 1210                 1215             


Gln Ala  Ile Leu Tyr Gln Asn  Glu Phe Leu Thr Leu  Asn Gly Lys 
    1220                 1225                 1230             


Lys Tyr  Tyr Phe Gly Ser Asp  Ser Lys Ala Val Thr  Gly Trp Arg 
    1235                 1240                 1245             


Ile Ile  Asn Asn Lys Lys Tyr  Tyr Phe Asn Pro Asn  Asn Ala Ile 
    1250                 1255                 1260             


Ala Ala  Ile His Leu Cys Thr  Ile Asn Asn Asp Lys  Tyr Tyr Phe 
    1265                 1270                 1275             


Ser Tyr  Asp Gly Ile Leu Gln  Asn Gly Tyr Ile Thr  Ile Glu Arg 
    1280                 1285                 1290             


Asn Asn  Phe Tyr Phe Asp Ala  Asn Asn Glu Ser Lys  Met Val Thr 
    1295                 1300                 1305             


Gly Val  Phe Lys Gly Pro Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala 
    1310                 1315                 1320             


Asn Thr  His Asn Asn Asn Ile  Glu Gly Gln Ala Ile  Val Tyr Gln 
    1325                 1330                 1335             


Asn Lys  Phe Leu Thr Leu Asn  Gly Lys Lys Tyr Tyr  Phe Asp Asn 
    1340                 1345                 1350             


Asp Ser  Lys Ala Val Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys 
    1355                 1360                 1365             


Tyr Tyr  Phe Asn Leu Asn Thr  Ala Glu Ala Ala Thr  Gly Trp Gln 
    1370                 1375                 1380             


Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn Leu Asn  Thr Ala Glu 
    1385                 1390                 1395             


Ala Ala  Thr Gly Trp Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe 
    1400                 1405                 1410             


Asn Thr  Asn Thr Phe Ile Ala  Ser Thr Gly Tyr Thr  Ser Ile Asn 
    1415                 1420                 1425             


Gly Lys  His Phe Tyr Phe Asn  Thr Asp Gly Ile Met  Gln Ile Gly 
    1430                 1435                 1440             


Val Phe  Lys Gly Pro Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn 
    1445                 1450                 1455             


Thr His  Asn Asn Asn Ile Glu  Gly Gln Ala Ile Leu  Tyr Gln Asn 
    1460                 1465                 1470             


Lys Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr Tyr Phe  Gly Ser Asp 
    1475                 1480                 1485             


Ser Lys  Ala Val Thr Gly Leu  Arg Thr Ile Asp Gly  Lys Lys Tyr 
    1490                 1495                 1500             


Tyr Phe  Asn Thr Asn Thr Ala  Val Ala Val Thr Gly  Trp Gln Thr 
    1505                 1510                 1515             


Ile Asn  Gly Lys Lys Tyr Tyr  Phe Asn Thr Asn Thr  Ser Ile Ala 
    1520                 1525                 1530             


Ser Thr  Gly Tyr Thr Ile Ile  Ser Gly Lys His Phe  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Asp  Gly Ile Met Gln Ile  Gly Val Phe Lys Gly  Pro Asp Gly 
    1550                 1555                 1560             


Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr Asp Ala Asn  Asn Ile Glu 
    1565                 1570                 1575             


Gly Gln  Ala Ile Arg Tyr Gln  Asn Arg Phe Leu Tyr  Leu His Asp 
    1580                 1585                 1590             


Asn Ile  Tyr Tyr Phe Gly Asn  Asn Ser Lys Ala Ala  Thr Gly Trp 
    1595                 1600                 1605             


Val Thr  Ile Asp Gly Asn Arg  Tyr Tyr Phe Glu Pro  Asn Thr Ala 
    1610                 1615                 1620             


Met Gly  Ala Asn Gly Tyr Lys  Thr Ile Asp Asn Lys  Asn Phe Tyr 
    1625                 1630                 1635             


Phe Arg  Asn Gly Leu Pro Gln  Ile Gly Val Phe Lys  Gly Ser Asn 
    1640                 1645                 1650             


Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr Asp Ala  Asn Asn Ile 
    1655                 1660                 1665             


Glu Gly  Gln Ala Ile Arg Tyr  Gln Asn Arg Phe Leu  His Leu Leu 
    1670                 1675                 1680             


Gly Lys  Ile Tyr Tyr Phe Gly  Asn Asn Ser Lys Ala  Val Thr Gly 
    1685                 1690                 1695             


Trp Gln  Thr Ile Asn Gly Lys  Val Tyr Tyr Phe Met  Pro Asp Thr 
    1700                 1705                 1710             


Ala Met  Ala Ala Ala Gly Gly  Leu Phe Glu Ile Asp  Gly Val Ile 
    1715                 1720                 1725             


Tyr Phe  Phe Gly Val Asp Gly  Val Lys Ala Pro Gly  Ile Tyr Gly 
    1730                 1735                 1740             


<210>  43
<211>  1749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  43

His His His His His His Ser His Met Ala Ser Asp Lys Ile Ile His 
1               5                   10                  15      


Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp Gly Ala 
            20                  25                  30          


Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys Met Ile 
        35                  40                  45              


Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys Leu Thr 
    50                  55                  60                  


Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro Lys Tyr 
65                  70                  75                  80  


Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly Glu Val 
                85                  90                  95      


Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys Glu Phe 
            100                 105                 110         


Leu Asp Ala Asn Leu Ala Arg Ala Leu Leu Ala Glu Ala Ala Ala Lys 
        115                 120                 125             


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
    130                 135                 140                 


Ala Ala Ala Lys Ala Ala Ala Gly Gly Ser Leu Val Pro Arg Gly Ser 
145                 150                 155                 160 


Gly Ser Ala Ala Ala Pro Phe Thr Met Glu Ser Lys Lys Tyr Gly Pro 
                165                 170                 175     


Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu Val 
            180                 185                 190         


Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys 
        195                 200                 205             


Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn 
    210                 215                 220                 


Ile Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser 
225                 230                 235                 240 


Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe 
                245                 250                 255     


Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp 
            260                 265                 270         


Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly 
        275                 280                 285             


Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr 
    290                 295                 300                 


Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys Pro 
305                 310                 315                 320 


Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp Thr Arg 
                325                 330                 335     


Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg Asn Lys Leu 
            340                 345                 350         


Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu Ser 
        355                 360                 365             


Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp Asp Leu Trp 
    370                 375                 380                 


Ile Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn Gly 
385                 390                 395                 400 


Thr Ile Lys Lys Gly Lys Leu Ile Lys Asp Val Leu Ser Lys Ile Asp 
                405                 410                 415     


Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser 
            420                 425                 430         


Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu 
        435                 440                 445             


Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser 
    450                 455                 460                 


Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu 
465                 470                 475                 480 


Ser Asn Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn 
                485                 490                 495     


Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala 
            500                 505                 510         


Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser 
        515                 520                 525             


Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn Ser 
    530                 535                 540                 


Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp Ile 
545                 550                 555                 560 


Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser 
                565                 570                 575     


Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val Asn 
            580                 585                 590         


Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val 
        595                 600                 605             


Lys Asn Ser Asp Gly His His Asn Thr Ser Asn Phe Met Asn Leu Phe 
    610                 615                 620                 


Leu Asp Asn Ile Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile Asn 
625                 630                 635                 640 


Phe Val Ile Asp Lys Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu Gly 
                645                 650                 655     


Tyr Val Glu Phe Ile Cys Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe 
            660                 665                 670         


Gly Glu Trp Lys Thr Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn 
        675                 680                 685             


Gly Arg Asn Val Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu 
    690                 695                 700                 


Asp Ile Ser Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile 
705                 710                 715                 720 


Asp Arg Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser 
                725                 730                 735     


Leu Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu 
            740                 745                 750         


Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn 
        755                 760                 765             


Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser Asp 
    770                 775                 780                 


Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu Gln 
785                 790                 795                 800 


Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser Phe Asn Lys 
                805                 810                 815     


Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser Leu Gly Tyr Ile 
            820                 825                 830         


Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn Glu Leu Asp Arg Asp 
        835                 840                 845             


His Leu Gly Phe Lys Ile Ile Asp Asn Lys Thr Tyr Tyr Tyr Asp Glu 
    850                 855                 860                 


Asp Ser Lys Leu Val Lys Gly Leu Ile Asn Ile Asn Asn Ser Leu Phe 
865                 870                 875                 880 


Tyr Phe Asp Pro Ile Glu Phe Asn Leu Val Thr Gly Trp Gln Thr Ile 
                885                 890                 895     


Asn Gly Lys Lys Tyr Tyr Phe Asp Ile Asn Thr Gly Ala Ala Leu Ile 
            900                 905                 910         


Ser Tyr Lys Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly 
        915                 920                 925             


Val Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe 
    930                 935                 940                 


Ala Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val 
945                 950                 955                 960 


Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp 
                965                 970                 975     


Asn Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys 
            980                 985                 990         


Tyr Tyr Phe Asn Pro Asn Asn Ala  Ile Ala Ala Val Gly  Leu Gln Val 
        995                 1000                 1005             


Ile Asp  Asn Asn Lys Tyr Tyr  Phe Asn Pro Asp Thr  Ala Ile Ile 
    1010                 1015                 1020             


Ser Lys  Gly Trp Gln Thr Val  Asn Gly Ser Arg Tyr  Tyr Phe Asp 
    1025                 1030                 1035             


Thr Asp  Thr Ala Ile Ala Phe  Asn Gly Tyr Lys Thr  Ile Asp Gly 
    1040                 1045                 1050             


Lys His  Phe Tyr Phe Asp Ser  Asp Cys Val Val Lys  Ile Gly Val 
    1055                 1060                 1065             


Phe Ser  Thr Ser Asn Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr 
    1070                 1075                 1080             


Tyr Asn  Asn Asn Ile Glu Gly  Gln Ala Ile Val Tyr  Gln Ser Lys 
    1085                 1090                 1095             


Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr Phe Asp  Asn Asn Ser 
    1100                 1105                 1110             


Lys Ala  Val Thr Gly Trp Gln  Thr Ile Asp Ser Lys  Lys Tyr Tyr 
    1115                 1120                 1125             


Phe Asn  Thr Asn Thr Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile 
    1130                 1135                 1140             


Asp Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn Thr Ala  Glu Ala Ala 
    1145                 1150                 1155             


Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr 
    1160                 1165                 1170             


Asn Thr  Ala Ile Ala Ser Thr  Gly Tyr Thr Ile Ile  Asn Gly Lys 
    1175                 1180                 1185             


His Phe  Tyr Phe Asn Thr Asp  Gly Ile Met Gln Ile  Gly Val Phe 
    1190                 1195                 1200             


Lys Gly  Pro Asn Gly Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr Asp 
    1205                 1210                 1215             


Ala Asn  Asn Ile Glu Gly Gln  Ala Ile Leu Tyr Gln  Asn Glu Phe 
    1220                 1225                 1230             


Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe Gly Ser  Asp Ser Lys 
    1235                 1240                 1245             


Ala Val  Thr Gly Trp Arg Ile  Ile Asn Asn Lys Lys  Tyr Tyr Phe 
    1250                 1255                 1260             


Asn Pro  Asn Asn Ala Ile Ala  Ala Ile His Leu Cys  Thr Ile Asn 
    1265                 1270                 1275             


Asn Asp  Lys Tyr Tyr Phe Ser  Tyr Asp Gly Ile Leu  Gln Asn Gly 
    1280                 1285                 1290             


Tyr Ile  Thr Ile Glu Arg Asn  Asn Phe Tyr Phe Asp  Ala Asn Asn 
    1295                 1300                 1305             


Glu Ser  Lys Met Val Thr Gly  Val Phe Lys Gly Pro  Asn Gly Phe 
    1310                 1315                 1320             


Glu Tyr  Phe Ala Pro Ala Asn  Thr His Asn Asn Asn  Ile Glu Gly 
    1325                 1330                 1335             


Gln Ala  Ile Val Tyr Gln Asn  Lys Phe Leu Thr Leu  Asn Gly Lys 
    1340                 1345                 1350             


Lys Tyr  Tyr Phe Asp Asn Asp  Ser Lys Ala Val Thr  Gly Trp Gln 
    1355                 1360                 1365             


Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn Leu Asn  Thr Ala Glu 
    1370                 1375                 1380             


Ala Ala  Thr Gly Trp Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe 
    1385                 1390                 1395             


Asn Leu  Asn Thr Ala Glu Ala  Ala Thr Gly Trp Gln  Thr Ile Asp 
    1400                 1405                 1410             


Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr Phe Ile  Ala Ser Thr 
    1415                 1420                 1425             


Gly Tyr  Thr Ser Ile Asn Gly  Lys His Phe Tyr Phe  Asn Thr Asp 
    1430                 1435                 1440             


Gly Ile  Met Gln Ile Gly Val  Phe Lys Gly Pro Asn  Gly Phe Glu 
    1445                 1450                 1455             


Tyr Phe  Ala Pro Ala Asn Thr  His Asn Asn Asn Ile  Glu Gly Gln 
    1460                 1465                 1470             


Ala Ile  Leu Tyr Gln Asn Lys  Phe Leu Thr Leu Asn  Gly Lys Lys 
    1475                 1480                 1485             


Tyr Tyr  Phe Gly Ser Asp Ser  Lys Ala Val Thr Gly  Leu Arg Thr 
    1490                 1495                 1500             


Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr Asn Thr  Ala Val Ala 
    1505                 1510                 1515             


Val Thr  Gly Trp Gln Thr Ile  Asn Gly Lys Lys Tyr  Tyr Phe Asn 
    1520                 1525                 1530             


Thr Asn  Thr Ser Ile Ala Ser  Thr Gly Tyr Thr Ile  Ile Ser Gly 
    1535                 1540                 1545             


Lys His  Phe Tyr Phe Asn Thr  Asp Gly Ile Met Gln  Ile Gly Val 
    1550                 1555                 1560             


Phe Lys  Gly Pro Asp Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr 
    1565                 1570                 1575             


Asp Ala  Asn Asn Ile Glu Gly  Gln Ala Ile Arg Tyr  Gln Asn Arg 
    1580                 1585                 1590             


Phe Leu  Tyr Leu His Asp Asn  Ile Tyr Tyr Phe Gly  Asn Asn Ser 
    1595                 1600                 1605             


Lys Ala  Ala Thr Gly Trp Val  Thr Ile Asp Gly Asn  Arg Tyr Tyr 
    1610                 1615                 1620             


Phe Glu  Pro Asn Thr Ala Met  Gly Ala Asn Gly Tyr  Lys Thr Ile 
    1625                 1630                 1635             


Asp Asn  Lys Asn Phe Tyr Phe  Arg Asn Gly Leu Pro  Gln Ile Gly 
    1640                 1645                 1650             


Val Phe  Lys Gly Ser Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn 
    1655                 1660                 1665             


Thr Asp  Ala Asn Asn Ile Glu  Gly Gln Ala Ile Arg  Tyr Gln Asn 
    1670                 1675                 1680             


Arg Phe  Leu His Leu Leu Gly  Lys Ile Tyr Tyr Phe  Gly Asn Asn 
    1685                 1690                 1695             


Ser Lys  Ala Val Thr Gly Trp  Gln Thr Ile Asn Gly  Lys Val Tyr 
    1700                 1705                 1710             


Tyr Phe  Met Pro Asp Thr Ala  Met Ala Ala Ala Gly  Gly Leu Phe 
    1715                 1720                 1725             


Glu Ile  Asp Gly Val Ile Tyr  Phe Phe Gly Val Asp  Gly Val Lys 
    1730                 1735                 1740             


Ala Pro  Gly Ile Tyr Gly 
    1745                 


<210>  44
<211>  2163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  44

His His His His His His His His His Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Ser His Met Ala Ser Asn Lys Glu Ile Leu 
        35                  40                  45              


Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu Pro Arg Glu Lys 
    50                  55                  60                  


Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala Thr Lys Lys Lys 
65                  70                  75                  80  


Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp Arg Lys Ser Gly 
                85                  90                  95      


Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp Glu Val Thr Gln 
            100                 105                 110         


Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr Glu Asp Glu Ser 
        115                 120                 125             


Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu Ser Val Thr Phe 
    130                 135                 140                 


Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile Val Gln Lys Val 
145                 150                 155                 160 


Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe Arg Glu His Glu 
                165                 170                 175     


Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn Arg Asp Asn Ile 
            180                 185                 190         


Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile Leu Arg Glu Asp 
        195                 200                 205             


Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg Val Arg Gly Val 
    210                 215                 220                 


Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln Leu Phe Val Thr 
225                 230                 235                 240 


Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg Ile Glu Val Pro 
                245                 250                 255     


Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala Ala Arg Asp Pro 
            260                 265                 270         


Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp Lys Arg Ile Asp 
        275                 280                 285             


Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg Val Gln Ala Val 
    290                 295                 300                 


Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val Leu Trp Asp Asp 
305                 310                 315                 320 


Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro Ala Asp Val Ala 
                325                 330                 335     


Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp Ile Ala Val Glu 
            340                 345                 350         


Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly Gln Asn Val Arg 
        355                 360                 365             


Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val Met Thr Val Asp 
    370                 375                 380                 


Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala Ala Ile Asp Thr 
385                 390                 395                 400 


Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala Thr Val Leu Val 
                405                 410                 415     


Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr Val Pro Met Lys 
            420                 425                 430         


Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr Val Glu Ala Leu 
        435                 440                 445             


Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala Gln Ala Gln Glu 
    450                 455                 460                 


Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu Leu Asn Leu Glu 
465                 470                 475                 480 


Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala Arg Gly Val Cys 
                485                 490                 495     


Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp Leu Ala Asp Ile 
            500                 505                 510         


Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile Met Ala Ala Arg 
        515                 520                 525             


Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala Leu Val Pro Arg 
    530                 535                 540                 


Gly Ser Val Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro 
545                 550                 555                 560 


Phe Thr Met Ser Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser 
                565                 570                 575     


Phe Asn Pro Lys Glu Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro 
            580                 585                 590         


Glu Leu Ser Thr Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser 
        595                 600                 605             


Asp Ile Glu Leu Glu Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn 
    610                 615                 620                 


Val Ile Ser Asn Ile Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu 
625                 630                 635                 640 


Ala Lys Asn Leu Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe 
                645                 650                 655     


Lys Leu Ile Glu Ser Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln 
            660                 665                 670         


Asn Glu Leu Glu Asp Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu 
        675                 680                 685             


Thr Asp Glu Gly Phe Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu 
    690                 695                 700                 


Ser Ile Phe Val Glu Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn 
705                 710                 715                 720 


His Ile Thr Glu Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr 
                725                 730                 735     


Val Asn Gly Lys Leu Val Lys Lys Val Asn Leu Asp Thr Thr His Glu 
            740                 745                 750         


Val Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr 
        755                 760                 765             


Asn Ser Ser Lys Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val 
    770                 775                 780                 


Gln Val Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp 
785                 790                 795                 800 


Ala Ala Lys Val Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile 
                805                 810                 815     


Asp Leu Leu Pro Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile 
            820                 825                 830         


Ile Asp Gly Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr 
        835                 840                 845             


Ser Asp Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met 
    850                 855                 860                 


Ala Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu 
865                 870                 875                 880 


Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile 
                885                 890                 895     


Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg Asp 
            900                 905                 910         


Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu Val Glu 
        915                 920                 925             


Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met Met Pro Gln 
    930                 935                 940                 


Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Val 
945                 950                 955                 960 


Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly Gly Ser Gly His Thr 
                965                 970                 975     


Val Thr Asp Asp Ile Asp His Phe Phe Ser Ala Pro Ser Ile Thr Tyr 
            980                 985                 990         


Arg Glu Pro His Leu Ser Ile Tyr  Asp Val Leu Glu Val  Gln Lys Glu 
        995                 1000                 1005             


Glu Leu  Asp Leu Ser Lys Asp  Leu Met Val Leu Pro  Asn Ala Pro 
    1010                 1015                 1020             


Asn Arg  Val Phe Ala Trp Glu  Thr Gly Trp Thr Pro  Gly Leu Arg 
    1025                 1030                 1035             


Ser Leu  Glu Asn Asp Gly Thr  Lys Leu Leu Asp Arg  Ile Arg Asp 
    1040                 1045                 1050             


Asn Tyr  Glu Gly Glu Phe Tyr  Trp Arg Tyr Phe Ala  Phe Ile Ala 
    1055                 1060                 1065             


Asp Ala  Leu Ile Thr Thr Leu  Lys Pro Arg Tyr Glu  Asp Thr Asn 
    1070                 1075                 1080             


Ile Arg  Ile Asn Leu Asp Ser  Asn Thr Arg Ser Phe  Ile Val Pro 
    1085                 1090                 1095             


Ile Ile  Thr Thr Glu Tyr Ile  Arg Glu Lys Leu Ser  Tyr Ser Phe 
    1100                 1105                 1110             


Tyr Gly  Ser Gly Gly Thr Tyr  Ala Leu Ser Leu Ser  Gln Tyr Asn 
    1115                 1120                 1125             


Met Gly  Ile Asn Ile Glu Leu  Ser Glu Ser Asp Val  Trp Ile Ile 
    1130                 1135                 1140             


Asp Val  Asp Asn Val Val Arg  Asp Val Thr Ile Glu  Ser Asp Lys 
    1145                 1150                 1155             


Ile Lys  Lys Gly Asp Leu Ile  Glu Gly Ile Leu Ser  Thr Leu Ser 
    1160                 1165                 1170             


Ile Glu  Glu Asn Lys Ile Ile  Leu Asn Ser His Glu  Ile Asn Phe 
    1175                 1180                 1185             


Ser Gly  Glu Val Asn Gly Ser  Asn Gly Phe Val Ser  Leu Thr Phe 
    1190                 1195                 1200             


Ser Ile  Leu Glu Gly Ile Asn  Ala Ile Ile Glu Val  Asp Leu Leu 
    1205                 1210                 1215             


Ser Lys  Ser Tyr Lys Leu Leu  Ile Ser Gly Glu Leu  Lys Ile Leu 
    1220                 1225                 1230             


Met Leu  Asn Ser Asn His Ile  Gln Gln Lys Ile Asp  Tyr Ile Gly 
    1235                 1240                 1245             


Phe Asn  Ser Glu Leu Gln Lys  Asn Ile Pro Tyr Ser  Phe Val Asp 
    1250                 1255                 1260             


Ser Glu  Gly Lys Glu Asn Gly  Phe Ile Asn Gly Ser  Thr Lys Glu 
    1265                 1270                 1275             


Gly Leu  Phe Val Ser Glu Leu  Pro Asp Val Val Leu  Ile Ser Lys 
    1280                 1285                 1290             


Val Tyr  Met Asp Asp Ser Lys  Pro Ser Phe Gly Tyr  Tyr Ser Asn 
    1295                 1300                 1305             


Asn Leu  Lys Asp Val Lys Val  Ile Thr Lys Asp Asn  Val Asn Ile 
    1310                 1315                 1320             


Leu Thr  Gly Tyr Tyr Leu Lys  Asp Asp Ile Lys Ile  Ser Leu Ser 
    1325                 1330                 1335             


Leu Thr  Leu Gln Asp Glu Lys  Thr Ile Lys Leu Asn  Ser Val His 
    1340                 1345                 1350             


Leu Asp  Glu Ser Gly Val Ala  Glu Ile Leu Lys Phe  Met Asn Arg 
    1355                 1360                 1365             


Lys Gly  Asn Thr Asn Thr Ser  Asp Ser Leu Met Ser  Phe Leu Glu 
    1370                 1375                 1380             


Ser Met  Asn Ile Lys Ser Ile  Phe Val Asn Phe Leu  Gln Ser Asn 
    1385                 1390                 1395             


Ile Lys  Phe Ile Leu Asp Ala  Asn Phe Ile Ile Ser  Gly Thr Thr 
    1400                 1405                 1410             


Ser Ile  Gly Gln Phe Glu Phe  Ile Cys Asp Glu Asn  Asp Asn Ile 
    1415                 1420                 1425             


Gln Pro  Tyr Phe Ile Lys Phe  Asn Thr Leu Glu Thr  Asn Tyr Thr 
    1430                 1435                 1440             


Leu Tyr  Val Gly Asn Arg Gln  Asn Met Ile Val Glu  Pro Asn Tyr 
    1445                 1450                 1455             


Asp Leu  Asp Asp Ser Gly Asp  Ile Ser Ser Thr Val  Ile Asn Phe 
    1460                 1465                 1470             


Ser Gln  Lys Tyr Leu Tyr Gly  Ile Asp Ser Cys Val  Asn Lys Val 
    1475                 1480                 1485             


Val Ile  Ser Pro Asn Ile Tyr  Thr Asp Glu Ile Asn  Ile Thr Pro 
    1490                 1495                 1500             


Val Tyr  Glu Thr Asn Asn Thr  Tyr Pro Glu Val Ile  Val Leu Asp 
    1505                 1510                 1515             


Ala Asn  Tyr Ile Asn Glu Lys  Ile Asn Val Asn Ile  Asn Asp Leu 
    1520                 1525                 1530             


Ser Ile  Arg Tyr Val Trp Ser  Asn Asp Gly Asn Asp  Phe Ile Leu 
    1535                 1540                 1545             


Met Ser  Thr Ser Glu Glu Asn  Lys Val Ser Gln Val  Lys Ile Arg 
    1550                 1555                 1560             


Phe Val  Asn Val Phe Lys Asp  Lys Thr Leu Ala Asn  Lys Leu Ser 
    1565                 1570                 1575             


Phe Asn  Phe Ser Asp Lys Gln  Asp Val Pro Val Ser  Glu Ile Ile 
    1580                 1585                 1590             


Leu Ser  Phe Thr Pro Ser Tyr  Tyr Glu Asp Gly Leu  Ile Gly Tyr 
    1595                 1600                 1605             


Asp Leu  Gly Leu Val Ser Leu  Tyr Asn Glu Lys Phe  Tyr Ile Asn 
    1610                 1615                 1620             


Asn Phe  Gly Met Met Val Ser  Gly Leu Ile Tyr Ile  Asn Asp Ser 
    1625                 1630                 1635             


Leu Tyr  Tyr Phe Lys Pro Pro  Val Asn Asn Leu Ile  Thr Gly Phe 
    1640                 1645                 1650             


Val Thr  Val Gly Asp Asp Lys  Tyr Tyr Phe Asn Pro  Ile Asn Gly 
    1655                 1660                 1665             


Gly Ala  Ala Ser Ile Gly Glu  Thr Ile Ile Asp Asp  Lys Asn Tyr 
    1670                 1675                 1680             


Tyr Phe  Asn Gln Ser Gly Val  Leu Gln Thr Gly Val  Phe Ser Thr 
    1685                 1690                 1695             


Glu Asp  Gly Phe Lys Tyr Phe  Ala Pro Ala Asn Thr  Leu Asp Glu 
    1700                 1705                 1710             


Asn Leu  Glu Gly Glu Ala Ile  Asp Phe Thr Gly Lys  Leu Ile Ile 
    1715                 1720                 1725             


Asp Glu  Asn Ile Tyr Tyr Phe  Asp Asp Asn Tyr Arg  Gly Ala Val 
    1730                 1735                 1740             


Glu Trp  Lys Glu Leu Asp Gly  Glu Met His Tyr Phe  Ser Pro Glu 
    1745                 1750                 1755             


Thr Gly  Lys Ala Phe Lys Gly  Leu Asn Gln Ile Gly  Asp Tyr Lys 
    1760                 1765                 1770             


Tyr Tyr  Phe Asn Ser Asp Gly  Val Met Gln Lys Gly  Phe Val Ser 
    1775                 1780                 1785             


Ile Asn  Asp Asn Lys His Tyr  Phe Asp Asp Ser Gly  Val Met Lys 
    1790                 1795                 1800             


Val Gly  Tyr Thr Glu Ile Asp  Gly Lys His Phe Tyr  Phe Ala Glu 
    1805                 1810                 1815             


Asn Gly  Glu Met Gln Ile Gly  Val Phe Asn Thr Glu  Asp Gly Phe 
    1820                 1825                 1830             


Lys Tyr  Phe Ala His His Asn  Glu Asp Leu Gly Asn  Glu Glu Gly 
    1835                 1840                 1845             


Glu Glu  Ile Ser Tyr Ser Gly  Ile Leu Asn Phe Asn  Asn Lys Ile 
    1850                 1855                 1860             


Tyr Tyr  Phe Asp Asp Ser Phe  Thr Ala Val Val Gly  Trp Lys Asp 
    1865                 1870                 1875             


Leu Glu  Asp Gly Ser Lys Tyr  Tyr Phe Asp Glu Asp  Thr Ala Glu 
    1880                 1885                 1890             


Ala Tyr  Ile Gly Leu Ser Leu  Ile Asn Asp Gly Gln  Tyr Tyr Phe 
    1895                 1900                 1905             


Asn Asp  Asp Gly Ile Met Gln  Val Gly Phe Val Thr  Ile Asn Asp 
    1910                 1915                 1920             


Lys Val  Phe Tyr Phe Ser Asp  Ser Gly Ile Ile Glu  Ser Gly Val 
    1925                 1930                 1935             


Gln Asn  Ile Asp Asp Asn Tyr  Phe Tyr Ile Asp Asp  Asn Gly Ile 
    1940                 1945                 1950             


Val Gln  Ile Gly Val Phe Asp  Thr Ser Asp Gly Tyr  Lys Tyr Phe 
    1955                 1960                 1965             


Ala Pro  Ala Asn Thr Val Asn  Asp Asn Ile Tyr Gly  Gln Ala Val 
    1970                 1975                 1980             


Glu Tyr  Ser Gly Leu Val Arg  Val Gly Glu Asp Val  Tyr Tyr Phe 
    1985                 1990                 1995             


Gly Glu  Thr Tyr Thr Ile Glu  Thr Gly Trp Ile Tyr  Asp Met Glu 
    2000                 2005                 2010             


Asn Glu  Ser Asp Lys Tyr Tyr  Phe Asn Pro Glu Thr  Lys Lys Ala 
    2015                 2020                 2025             


Cys Lys  Gly Ile Asn Leu Ile  Asp Asp Ile Lys Tyr  Tyr Phe Asp 
    2030                 2035                 2040             


Glu Lys  Gly Ile Met Arg Thr  Gly Leu Ile Ser Phe  Glu Asn Asn 
    2045                 2050                 2055             


Asn Tyr  Tyr Phe Asn Glu Asn  Gly Glu Met Gln Phe  Gly Tyr Ile 
    2060                 2065                 2070             


Asn Ile  Glu Asp Lys Met Phe  Tyr Phe Gly Glu Asp  Gly Val Met 
    2075                 2080                 2085             


Gln Ile  Gly Val Phe Asn Thr  Pro Asp Gly Phe Lys  Tyr Phe Ala 
    2090                 2095                 2100             


His Gln  Asn Thr Leu Asp Glu  Asn Phe Glu Gly Glu  Ser Ile Asn 
    2105                 2110                 2115             


Tyr Thr  Gly Trp Leu Asp Leu  Asp Glu Lys Arg Tyr  Tyr Phe Thr 
    2120                 2125                 2130             


Asp Glu  Tyr Ile Ala Ala Thr  Gly Ser Val Ile Ile  Asp Gly Glu 
    2135                 2140                 2145             


Glu Tyr  Tyr Phe Asp Pro Asp  Thr Ala Gln Leu Val  Ile Ser Glu 
    2150                 2155                 2160             


<210>  45
<211>  2151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  45

His His His His His His Ser His Met Ala Ser Asn Lys Glu Ile Leu 
1               5                   10                  15      


Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu Pro Arg Glu Lys 
            20                  25                  30          


Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala Thr Lys Lys Lys 
        35                  40                  45              


Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp Arg Lys Ser Gly 
    50                  55                  60                  


Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp Glu Val Thr Gln 
65                  70                  75                  80  


Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr Glu Asp Glu Ser 
                85                  90                  95      


Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu Ser Val Thr Phe 
            100                 105                 110         


Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile Val Gln Lys Val 
        115                 120                 125             


Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe Arg Glu His Glu 
    130                 135                 140                 


Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn Arg Asp Asn Ile 
145                 150                 155                 160 


Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile Leu Arg Glu Asp 
                165                 170                 175     


Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg Val Arg Gly Val 
            180                 185                 190         


Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln Leu Phe Val Thr 
        195                 200                 205             


Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg Ile Glu Val Pro 
    210                 215                 220                 


Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala Ala Arg Asp Pro 
225                 230                 235                 240 


Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp Lys Arg Ile Asp 
                245                 250                 255     


Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg Val Gln Ala Val 
            260                 265                 270         


Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val Leu Trp Asp Asp 
        275                 280                 285             


Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro Ala Asp Val Ala 
    290                 295                 300                 


Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp Ile Ala Val Glu 
305                 310                 315                 320 


Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly Gln Asn Val Arg 
                325                 330                 335     


Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val Met Thr Val Asp 
            340                 345                 350         


Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala Ala Ile Asp Thr 
        355                 360                 365             


Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala Thr Val Leu Val 
    370                 375                 380                 


Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr Val Pro Met Lys 
385                 390                 395                 400 


Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr Val Glu Ala Leu 
                405                 410                 415     


Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala Gln Ala Gln Glu 
            420                 425                 430         


Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu Leu Asn Leu Glu 
        435                 440                 445             


Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala Arg Gly Val Cys 
    450                 455                 460                 


Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp Leu Ala Asp Ile 
465                 470                 475                 480 


Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile Met Ala Ala Arg 
                485                 490                 495     


Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala Leu Gly Gly Ser 
            500                 505                 510         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        515                 520                 525             


Gly Ser Gly Gly Ser Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Ser 
    530                 535                 540                 


Ala Ala Ala Pro Phe Thr Met Ser Ile Ile Lys Asp Ile Ser Ser Lys 
545                 550                 555                 560 


Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn Lys Ile Thr Val Lys Ser 
                565                 570                 575     


Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu Gln Glu Ile Arg Asn Asn 
            580                 585                 590         


Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu Lys Val Met Leu Thr Glu 
        595                 600                 605             


Cys Glu Ile Asn Val Ile Ser Asn Ile Asp Thr Gln Ile Val Glu Glu 
    610                 615                 620                 


Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser Asp Ser Ile Asn Tyr Ile 
625                 630                 635                 640 


Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile Ser Asp Ala Leu Cys Asp 
                645                 650                 655     


Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser His Phe Ile Ser Phe Glu 
            660                 665                 670         


Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser Ile Arg Phe Ile Asn Lys 
        675                 680                 685             


Glu Thr Gly Glu Ser Ile Phe Val Glu Thr Glu Lys Thr Ile Phe Ser 
    690                 695                 700                 


Glu Tyr Ala Asn His Ile Thr Glu Glu Ile Ser Lys Ile Lys Gly Thr 
705                 710                 715                 720 


Ile Phe Asp Thr Val Asn Gly Lys Leu Val Lys Lys Val Asn Leu Asp 
                725                 730                 735     


Thr Thr His Glu Val Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser 
            740                 745                 750         


Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser Leu Ser Asn Leu Ser Val 
        755                 760                 765             


Ala Met Lys Val Gln Val Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn 
    770                 775                 780                 


Thr Ile Thr Asp Ala Ala Lys Val Val Glu Leu Val Ser Thr Ala Leu 
785                 790                 795                 800 


Asp Glu Thr Ile Asp Leu Leu Pro Thr Leu Ser Glu Gly Leu Pro Ile 
                805                 810                 815     


Ile Ala Thr Ile Ile Asp Gly Val Ser Leu Gly Ala Ala Ile Lys Glu 
            820                 825                 830         


Leu Ser Glu Thr Ser Asp Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys 
        835                 840                 845             


Ile Gly Ile Met Ala Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile 
    850                 855                 860                 


Thr Ser Ser Leu Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro 
865                 870                 875                 880 


Leu Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu 
                885                 890                 895     


Val Leu Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val 
            900                 905                 910         


Ser Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile 
        915                 920                 925             


Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn 
    930                 935                 940                 


Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly Gly 
945                 950                 955                 960 


Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser Ala Pro 
                965                 970                 975     


Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp Val Leu Glu 
            980                 985                 990         


Val Gln Lys Glu Glu Leu Asp Leu  Ser Lys Asp Leu Met  Val Leu Pro 
        995                 1000                 1005             


Asn Ala  Pro Asn Arg Val Phe  Ala Trp Glu Thr Gly  Trp Thr Pro 
    1010                 1015                 1020             


Gly Leu  Arg Ser Leu Glu Asn  Asp Gly Thr Lys Leu  Leu Asp Arg 
    1025                 1030                 1035             


Ile Arg  Asp Asn Tyr Glu Gly  Glu Phe Tyr Trp Arg  Tyr Phe Ala 
    1040                 1045                 1050             


Phe Ile  Ala Asp Ala Leu Ile  Thr Thr Leu Lys Pro  Arg Tyr Glu 
    1055                 1060                 1065             


Asp Thr  Asn Ile Arg Ile Asn  Leu Asp Ser Asn Thr  Arg Ser Phe 
    1070                 1075                 1080             


Ile Val  Pro Ile Ile Thr Thr  Glu Tyr Ile Arg Glu  Lys Leu Ser 
    1085                 1090                 1095             


Tyr Ser  Phe Tyr Gly Ser Gly  Gly Thr Tyr Ala Leu  Ser Leu Ser 
    1100                 1105                 1110             


Gln Tyr  Asn Met Gly Ile Asn  Ile Glu Leu Ser Glu  Ser Asp Val 
    1115                 1120                 1125             


Trp Ile  Ile Asp Val Asp Asn  Val Val Arg Asp Val  Thr Ile Glu 
    1130                 1135                 1140             


Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile Glu Gly  Ile Leu Ser 
    1145                 1150                 1155             


Thr Leu  Ser Ile Glu Glu Asn  Lys Ile Ile Leu Asn  Ser His Glu 
    1160                 1165                 1170             


Ile Asn  Phe Ser Gly Glu Val  Asn Gly Ser Asn Gly  Phe Val Ser 
    1175                 1180                 1185             


Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn Ala Ile  Ile Glu Val 
    1190                 1195                 1200             


Asp Leu  Leu Ser Lys Ser Tyr  Lys Leu Leu Ile Ser  Gly Glu Leu 
    1205                 1210                 1215             


Lys Ile  Leu Met Leu Asn Ser  Asn His Ile Gln Gln  Lys Ile Asp 
    1220                 1225                 1230             


Tyr Ile  Gly Phe Asn Ser Glu  Leu Gln Lys Asn Ile  Pro Tyr Ser 
    1235                 1240                 1245             


Phe Val  Asp Ser Glu Gly Lys  Glu Asn Gly Phe Ile  Asn Gly Ser 
    1250                 1255                 1260             


Thr Lys  Glu Gly Leu Phe Val  Ser Glu Leu Pro Asp  Val Val Leu 
    1265                 1270                 1275             


Ile Ser  Lys Val Tyr Met Asp  Asp Ser Lys Pro Ser  Phe Gly Tyr 
    1280                 1285                 1290             


Tyr Ser  Asn Asn Leu Lys Asp  Val Lys Val Ile Thr  Lys Asp Asn 
    1295                 1300                 1305             


Val Asn  Ile Leu Thr Gly Tyr  Tyr Leu Lys Asp Asp  Ile Lys Ile 
    1310                 1315                 1320             


Ser Leu  Ser Leu Thr Leu Gln  Asp Glu Lys Thr Ile  Lys Leu Asn 
    1325                 1330                 1335             


Ser Val  His Leu Asp Glu Ser  Gly Val Ala Glu Ile  Leu Lys Phe 
    1340                 1345                 1350             


Met Asn  Arg Lys Gly Asn Thr  Asn Thr Ser Asp Ser  Leu Met Ser 
    1355                 1360                 1365             


Phe Leu  Glu Ser Met Asn Ile  Lys Ser Ile Phe Val  Asn Phe Leu 
    1370                 1375                 1380             


Gln Ser  Asn Ile Lys Phe Ile  Leu Asp Ala Asn Phe  Ile Ile Ser 
    1385                 1390                 1395             


Gly Thr  Thr Ser Ile Gly Gln  Phe Glu Phe Ile Cys  Asp Glu Asn 
    1400                 1405                 1410             


Asp Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe Asn Thr  Leu Glu Thr 
    1415                 1420                 1425             


Asn Tyr  Thr Leu Tyr Val Gly  Asn Arg Gln Asn Met  Ile Val Glu 
    1430                 1435                 1440             


Pro Asn  Tyr Asp Leu Asp Asp  Ser Gly Asp Ile Ser  Ser Thr Val 
    1445                 1450                 1455             


Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly Ile Asp  Ser Cys Val 
    1460                 1465                 1470             


Asn Lys  Val Val Ile Ser Pro  Asn Ile Tyr Thr Asp  Glu Ile Asn 
    1475                 1480                 1485             


Ile Thr  Pro Val Tyr Glu Thr  Asn Asn Thr Tyr Pro  Glu Val Ile 
    1490                 1495                 1500             


Val Leu  Asp Ala Asn Tyr Ile  Asn Glu Lys Ile Asn  Val Asn Ile 
    1505                 1510                 1515             


Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser Asn Asp  Gly Asn Asp 
    1520                 1525                 1530             


Phe Ile  Leu Met Ser Thr Ser  Glu Glu Asn Lys Val  Ser Gln Val 
    1535                 1540                 1545             


Lys Ile  Arg Phe Val Asn Val  Phe Lys Asp Lys Thr  Leu Ala Asn 
    1550                 1555                 1560             


Lys Leu  Ser Phe Asn Phe Ser  Asp Lys Gln Asp Val  Pro Val Ser 
    1565                 1570                 1575             


Glu Ile  Ile Leu Ser Phe Thr  Pro Ser Tyr Tyr Glu  Asp Gly Leu 
    1580                 1585                 1590             


Ile Gly  Tyr Asp Leu Gly Leu  Val Ser Leu Tyr Asn  Glu Lys Phe 
    1595                 1600                 1605             


Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser Gly Leu  Ile Tyr Ile 
    1610                 1615                 1620             


Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro Val Asn  Asn Leu Ile 
    1625                 1630                 1635             


Thr Gly  Phe Val Thr Val Gly  Asp Asp Lys Tyr Tyr  Phe Asn Pro 
    1640                 1645                 1650             


Ile Asn  Gly Gly Ala Ala Ser  Ile Gly Glu Thr Ile  Ile Asp Asp 
    1655                 1660                 1665             


Lys Asn  Tyr Tyr Phe Asn Gln  Ser Gly Val Leu Gln  Thr Gly Val 
    1670                 1675                 1680             


Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe Ala Pro  Ala Asn Thr 
    1685                 1690                 1695             


Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile Asp Phe  Thr Gly Lys 
    1700                 1705                 1710             


Leu Ile  Ile Asp Glu Asn Ile  Tyr Tyr Phe Asp Asp  Asn Tyr Arg 
    1715                 1720                 1725             


Gly Ala  Val Glu Trp Lys Glu  Leu Asp Gly Glu Met  His Tyr Phe 
    1730                 1735                 1740             


Ser Pro  Glu Thr Gly Lys Ala  Phe Lys Gly Leu Asn  Gln Ile Gly 
    1745                 1750                 1755             


Asp Tyr  Lys Tyr Tyr Phe Asn  Ser Asp Gly Val Met  Gln Lys Gly 
    1760                 1765                 1770             


Phe Val  Ser Ile Asn Asp Asn  Lys His Tyr Phe Asp  Asp Ser Gly 
    1775                 1780                 1785             


Val Met  Lys Val Gly Tyr Thr  Glu Ile Asp Gly Lys  His Phe Tyr 
    1790                 1795                 1800             


Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly Val Phe  Asn Thr Glu 
    1805                 1810                 1815             


Asp Gly  Phe Lys Tyr Phe Ala  His His Asn Glu Asp  Leu Gly Asn 
    1820                 1825                 1830             


Glu Glu  Gly Glu Glu Ile Ser  Tyr Ser Gly Ile Leu  Asn Phe Asn 
    1835                 1840                 1845             


Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe Thr Ala  Val Val Gly 
    1850                 1855                 1860             


Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr Tyr Phe  Asp Glu Asp 
    1865                 1870                 1875             


Thr Ala  Glu Ala Tyr Ile Gly  Leu Ser Leu Ile Asn  Asp Gly Gln 
    1880                 1885                 1890             


Tyr Tyr  Phe Asn Asp Asp Gly  Ile Met Gln Val Gly  Phe Val Thr 
    1895                 1900                 1905             


Ile Asn  Asp Lys Val Phe Tyr  Phe Ser Asp Ser Gly  Ile Ile Glu 
    1910                 1915                 1920             


Ser Gly  Val Gln Asn Ile Asp  Asp Asn Tyr Phe Tyr  Ile Asp Asp 
    1925                 1930                 1935             


Asn Gly  Ile Val Gln Ile Gly  Val Phe Asp Thr Ser  Asp Gly Tyr 
    1940                 1945                 1950             


Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn Asp Asn  Ile Tyr Gly 
    1955                 1960                 1965             


Gln Ala  Val Glu Tyr Ser Gly  Leu Val Arg Val Gly  Glu Asp Val 
    1970                 1975                 1980             


Tyr Tyr  Phe Gly Glu Thr Tyr  Thr Ile Glu Thr Gly  Trp Ile Tyr 
    1985                 1990                 1995             


Asp Met  Glu Asn Glu Ser Asp  Lys Tyr Tyr Phe Asn  Pro Glu Thr 
    2000                 2005                 2010             


Lys Lys  Ala Cys Lys Gly Ile  Asn Leu Ile Asp Asp  Ile Lys Tyr 
    2015                 2020                 2025             


Tyr Phe  Asp Glu Lys Gly Ile  Met Arg Thr Gly Leu  Ile Ser Phe 
    2030                 2035                 2040             


Glu Asn  Asn Asn Tyr Tyr Phe  Asn Glu Asn Gly Glu  Met Gln Phe 
    2045                 2050                 2055             


Gly Tyr  Ile Asn Ile Glu Asp  Lys Met Phe Tyr Phe  Gly Glu Asp 
    2060                 2065                 2070             


Gly Val  Met Gln Ile Gly Val  Phe Asn Thr Pro Asp  Gly Phe Lys 
    2075                 2080                 2085             


Tyr Phe  Ala His Gln Asn Thr  Leu Asp Glu Asn Phe  Glu Gly Glu 
    2090                 2095                 2100             


Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu Asp Glu  Lys Arg Tyr 
    2105                 2110                 2115             


Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr Gly Ser  Val Ile Ile 
    2120                 2125                 2130             


Asp Gly  Glu Glu Tyr Tyr Phe  Asp Pro Asp Thr Ala  Gln Leu Val 
    2135                 2140                 2145             


Ile Ser  Glu 
    2150     


<210>  46
<211>  2170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  46

His His His His His His His His His His Gly Gly Ser Leu Ala Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Ala Gly Gly Ser His Met 
        35                  40                  45              


Ala Ser Asn Lys Glu Ile Leu Ala Val Val Glu Ala Val Ser Asn Glu 
    50                  55                  60                  


Lys Ala Leu Pro Arg Glu Lys Ile Phe Glu Ala Leu Glu Ser Ala Leu 
65                  70                  75                  80  


Ala Thr Ala Thr Lys Lys Lys Tyr Glu Gln Glu Ile Asp Val Arg Val 
                85                  90                  95      


Gln Ile Asp Arg Lys Ser Gly Asp Phe Asp Thr Phe Arg Arg Trp Leu 
            100                 105                 110         


Val Val Asp Glu Val Thr Gln Pro Thr Lys Glu Ile Thr Leu Glu Ala 
        115                 120                 125             


Ala Arg Tyr Glu Asp Glu Ser Leu Asn Leu Gly Asp Tyr Val Glu Asp 
    130                 135                 140                 


Gln Ile Glu Ser Val Thr Phe Asp Arg Ile Thr Thr Gln Thr Ala Lys 
145                 150                 155                 160 


Gln Val Ile Val Gln Lys Val Arg Glu Ala Glu Arg Ala Met Val Val 
                165                 170                 175     


Asp Gln Phe Arg Glu His Glu Gly Glu Ile Ile Thr Gly Val Val Lys 
            180                 185                 190         


Lys Val Asn Arg Asp Asn Ile Ser Leu Asp Leu Gly Asn Asn Ala Glu 
        195                 200                 205             


Ala Val Ile Leu Arg Glu Asp Met Leu Pro Arg Glu Asn Phe Arg Pro 
    210                 215                 220                 


Gly Asp Arg Val Arg Gly Val Leu Tyr Ser Val Arg Pro Glu Ala Arg 
225                 230                 235                 240 


Gly Ala Gln Leu Phe Val Thr Arg Ser Lys Pro Glu Met Leu Ile Glu 
                245                 250                 255     


Leu Phe Arg Ile Glu Val Pro Glu Ile Gly Glu Glu Val Ile Glu Ile 
            260                 265                 270         


Lys Ala Ala Ala Arg Asp Pro Gly Ser Arg Ala Lys Ile Ala Val Lys 
        275                 280                 285             


Thr Asn Asp Lys Arg Ile Asp Pro Val Gly Ala Cys Val Gly Met Arg 
    290                 295                 300                 


Gly Ala Arg Val Gln Ala Val Ser Thr Glu Leu Gly Gly Glu Arg Ile 
305                 310                 315                 320 


Asp Ile Val Leu Trp Asp Asp Asn Pro Ala Gln Phe Val Ile Asn Ala 
                325                 330                 335     


Met Ala Pro Ala Asp Val Ala Ser Ile Val Val Asp Glu Asp Lys His 
            340                 345                 350         


Thr Met Asp Ile Ala Val Glu Ala Gly Asn Leu Ala Gln Ala Ile Gly 
        355                 360                 365             


Arg Asn Gly Gln Asn Val Arg Leu Ala Ser Gln Leu Ser Gly Trp Glu 
    370                 375                 380                 


Leu Asn Val Met Thr Val Asp Asp Leu Gln Ala Lys His Gln Ala Glu 
385                 390                 395                 400 


Ala His Ala Ala Ile Asp Thr Phe Thr Lys Tyr Leu Asp Ile Asp Glu 
                405                 410                 415     


Asp Phe Ala Thr Val Leu Val Glu Glu Gly Phe Ser Thr Leu Glu Glu 
            420                 425                 430         


Leu Ala Tyr Val Pro Met Lys Glu Leu Leu Glu Ile Glu Gly Leu Asp 
        435                 440                 445             


Glu Pro Thr Val Glu Ala Leu Arg Glu Arg Ala Lys Asn Ala Leu Ala 
    450                 455                 460                 


Thr Ile Ala Gln Ala Gln Glu Glu Ser Leu Gly Asp Asn Lys Pro Ala 
465                 470                 475                 480 


Asp Asp Leu Leu Asn Leu Glu Gly Val Asp Arg Asp Leu Ala Phe Lys 
                485                 490                 495     


Leu Ala Ala Arg Gly Val Cys Thr Leu Glu Asp Leu Ala Glu Gln Gly 
            500                 505                 510         


Ile Asp Asp Leu Ala Asp Ile Glu Gly Leu Thr Asp Glu Lys Ala Gly 
        515                 520                 525             


Ala Leu Ile Met Ala Ala Arg Asn Ile Cys Trp Phe Gly Asp Glu Ala 
    530                 535                 540                 


Ser Gly Ala Leu Val Pro Arg Gly Ser Val Thr Ser Leu Tyr Lys Lys 
545                 550                 555                 560 


Ala Gly Ser Ala Ala Ala Pro Phe Thr Met Ser Ile Ile Lys Asp Ile 
                565                 570                 575     


Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn Lys Ile Thr 
            580                 585                 590         


Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu Gln Glu Ile 
        595                 600                 605             


Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu Lys Val Met 
    610                 615                 620                 


Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp Thr Gln Ile 
625                 630                 635                 640 


Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser Asp Ser Ile 
                645                 650                 655     


Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile Ser Asp Ala 
            660                 665                 670         


Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser His Phe Ile 
        675                 680                 685             


Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser Ile Arg Phe 
    690                 695                 700                 


Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr Glu Lys Thr 
705                 710                 715                 720 


Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile Ser Lys Ile 
                725                 730                 735     


Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val Lys Lys Val 
            740                 745                 750         


Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala Ala Phe Phe 
        755                 760                 765             


Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser Leu Ser Asn 
    770                 775                 780                 


Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu Phe Ser Thr 
785                 790                 795                 800 


Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu Leu Val Ser 
                805                 810                 815     


Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr Leu Ser Glu Gly 
            820                 825                 830         


Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val Ser Leu Gly Ala Ala 
        835                 840                 845             


Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro Leu Leu Arg Gln Glu Ile 
    850                 855                 860                 


Glu Ala Lys Ile Gly Ile Met Ala Val Asn Leu Thr Thr Ala Thr Thr 
865                 870                 875                 880 


Ala Ile Ile Thr Ser Ser Leu Gly Ile Ala Ser Gly Phe Ser Ile Leu 
                885                 890                 895     


Leu Val Pro Leu Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn 
            900                 905                 910         


Asn Glu Leu Val Leu Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe 
        915                 920                 925             


Lys His Val Ser Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp 
    930                 935                 940                 


Asp Lys Ile Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp 
945                 950                 955                 960 


Phe Asn Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met 
                965                 970                 975     


Glu Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe 
            980                 985                 990         


Ser Ala Pro Ser Ile Thr Tyr Arg  Glu Pro His Leu Ser  Ile Tyr Asp 
        995                 1000                 1005             


Val Leu  Glu Val Gln Lys Glu  Glu Leu Asp Leu Ser  Lys Asp Leu 
    1010                 1015                 1020             


Met Val  Leu Pro Asn Ala Pro  Asn Arg Val Phe Ala  Trp Glu Thr 
    1025                 1030                 1035             


Gly Trp  Thr Pro Gly Leu Arg  Ser Leu Glu Asn Asp  Gly Thr Lys 
    1040                 1045                 1050             


Leu Leu  Asp Arg Ile Arg Asp  Asn Tyr Glu Gly Glu  Phe Tyr Trp 
    1055                 1060                 1065             


Arg Tyr  Phe Ala Phe Ile Ala  Asp Ala Leu Ile Thr  Thr Leu Lys 
    1070                 1075                 1080             


Pro Arg  Tyr Glu Asp Thr Asn  Ile Arg Ile Asn Leu  Asp Ser Asn 
    1085                 1090                 1095             


Thr Arg  Ser Phe Ile Val Pro  Ile Ile Thr Thr Glu  Tyr Ile Arg 
    1100                 1105                 1110             


Glu Lys  Leu Ser Tyr Ser Phe  Tyr Gly Ser Gly Gly  Thr Tyr Ala 
    1115                 1120                 1125             


Leu Ser  Leu Ser Gln Tyr Asn  Met Gly Ile Asn Ile  Glu Leu Ser 
    1130                 1135                 1140             


Glu Ser  Asp Val Trp Ile Ile  Asp Val Asp Asn Val  Val Arg Asp 
    1145                 1150                 1155             


Val Thr  Ile Glu Ser Asp Lys  Ile Lys Lys Gly Asp  Leu Ile Glu 
    1160                 1165                 1170             


Gly Ile  Leu Ser Thr Leu Ser  Ile Glu Glu Asn Lys  Ile Ile Leu 
    1175                 1180                 1185             


Asn Ser  His Glu Ile Asn Phe  Ser Gly Glu Val Asn  Gly Ser Asn 
    1190                 1195                 1200             


Gly Phe  Val Ser Leu Thr Phe  Ser Ile Leu Glu Gly  Ile Asn Ala 
    1205                 1210                 1215             


Ile Ile  Glu Val Asp Leu Leu  Ser Lys Ser Tyr Lys  Leu Leu Ile 
    1220                 1225                 1230             


Ser Gly  Glu Leu Lys Ile Leu  Met Leu Asn Ser Asn  His Ile Gln 
    1235                 1240                 1245             


Gln Lys  Ile Asp Tyr Ile Gly  Phe Asn Ser Glu Leu  Gln Lys Asn 
    1250                 1255                 1260             


Ile Pro  Tyr Ser Phe Val Asp  Ser Glu Gly Lys Glu  Asn Gly Phe 
    1265                 1270                 1275             


Ile Asn  Gly Ser Thr Lys Glu  Gly Leu Phe Val Ser  Glu Leu Pro 
    1280                 1285                 1290             


Asp Val  Val Leu Ile Ser Lys  Val Tyr Met Asp Asp  Ser Lys Pro 
    1295                 1300                 1305             


Ser Phe  Gly Tyr Tyr Ser Asn  Asn Leu Lys Asp Val  Lys Val Ile 
    1310                 1315                 1320             


Thr Lys  Asp Asn Val Asn Ile  Leu Thr Gly Tyr Tyr  Leu Lys Asp 
    1325                 1330                 1335             


Asp Ile  Lys Ile Ser Leu Ser  Leu Thr Leu Gln Asp  Glu Lys Thr 
    1340                 1345                 1350             


Ile Lys  Leu Asn Ser Val His  Leu Asp Glu Ser Gly  Val Ala Glu 
    1355                 1360                 1365             


Ile Leu  Lys Phe Met Asn Arg  Lys Gly Asn Thr Asn  Thr Ser Asp 
    1370                 1375                 1380             


Ser Leu  Met Ser Phe Leu Glu  Ser Met Asn Ile Lys  Ser Ile Phe 
    1385                 1390                 1395             


Val Asn  Phe Leu Gln Ser Asn  Ile Lys Phe Ile Leu  Asp Ala Asn 
    1400                 1405                 1410             


Phe Ile  Ile Ser Gly Thr Thr  Ser Ile Gly Gln Phe  Glu Phe Ile 
    1415                 1420                 1425             


Cys Asp  Glu Asn Asp Asn Ile  Gln Pro Tyr Phe Ile  Lys Phe Asn 
    1430                 1435                 1440             


Thr Leu  Glu Thr Asn Tyr Thr  Leu Tyr Val Gly Asn  Arg Gln Asn 
    1445                 1450                 1455             


Met Ile  Val Glu Pro Asn Tyr  Asp Leu Asp Asp Ser  Gly Asp Ile 
    1460                 1465                 1470             


Ser Ser  Thr Val Ile Asn Phe  Ser Gln Lys Tyr Leu  Tyr Gly Ile 
    1475                 1480                 1485             


Asp Ser  Cys Val Asn Lys Val  Val Ile Ser Pro Asn  Ile Tyr Thr 
    1490                 1495                 1500             


Asp Glu  Ile Asn Ile Thr Pro  Val Tyr Glu Thr Asn  Asn Thr Tyr 
    1505                 1510                 1515             


Pro Glu  Val Ile Val Leu Asp  Ala Asn Tyr Ile Asn  Glu Lys Ile 
    1520                 1525                 1530             


Asn Val  Asn Ile Asn Asp Leu  Ser Ile Arg Tyr Val  Trp Ser Asn 
    1535                 1540                 1545             


Asp Gly  Asn Asp Phe Ile Leu  Met Ser Thr Ser Glu  Glu Asn Lys 
    1550                 1555                 1560             


Val Ser  Gln Val Lys Ile Arg  Phe Val Asn Val Phe  Lys Asp Lys 
    1565                 1570                 1575             


Thr Leu  Ala Asn Lys Leu Ser  Phe Asn Phe Ser Asp  Lys Gln Asp 
    1580                 1585                 1590             


Val Pro  Val Ser Glu Ile Ile  Leu Ser Phe Thr Pro  Ser Tyr Tyr 
    1595                 1600                 1605             


Glu Asp  Gly Leu Ile Gly Tyr  Asp Leu Gly Leu Val  Ser Leu Tyr 
    1610                 1615                 1620             


Asn Glu  Lys Phe Tyr Ile Asn  Asn Phe Gly Met Met  Val Ser Gly 
    1625                 1630                 1635             


Leu Ile  Tyr Ile Asn Asp Ser  Leu Tyr Tyr Phe Lys  Pro Pro Val 
    1640                 1645                 1650             


Asn Asn  Leu Ile Thr Gly Phe  Val Thr Val Gly Asp  Asp Lys Tyr 
    1655                 1660                 1665             


Tyr Phe  Asn Pro Ile Asn Gly  Gly Ala Ala Ser Ile  Gly Glu Thr 
    1670                 1675                 1680             


Ile Ile  Asp Asp Lys Asn Tyr  Tyr Phe Asn Gln Ser  Gly Val Leu 
    1685                 1690                 1695             


Gln Thr  Gly Val Phe Ser Thr  Glu Asp Gly Phe Lys  Tyr Phe Ala 
    1700                 1705                 1710             


Pro Ala  Asn Thr Leu Asp Glu  Asn Leu Glu Gly Glu  Ala Ile Asp 
    1715                 1720                 1725             


Phe Thr  Gly Lys Leu Ile Ile  Asp Glu Asn Ile Tyr  Tyr Phe Asp 
    1730                 1735                 1740             


Asp Asn  Tyr Arg Gly Ala Val  Glu Trp Lys Glu Leu  Asp Gly Glu 
    1745                 1750                 1755             


Met His  Tyr Phe Ser Pro Glu  Thr Gly Lys Ala Phe  Lys Gly Leu 
    1760                 1765                 1770             


Asn Gln  Ile Gly Asp Tyr Lys  Tyr Tyr Phe Asn Ser  Asp Gly Val 
    1775                 1780                 1785             


Met Gln  Lys Gly Phe Val Ser  Ile Asn Asp Asn Lys  His Tyr Phe 
    1790                 1795                 1800             


Asp Asp  Ser Gly Val Met Lys  Val Gly Tyr Thr Glu  Ile Asp Gly 
    1805                 1810                 1815             


Lys His  Phe Tyr Phe Ala Glu  Asn Gly Glu Met Gln  Ile Gly Val 
    1820                 1825                 1830             


Phe Asn  Thr Glu Asp Gly Phe  Lys Tyr Phe Ala His  His Asn Glu 
    1835                 1840                 1845             


Asp Leu  Gly Asn Glu Glu Gly  Glu Glu Ile Ser Tyr  Ser Gly Ile 
    1850                 1855                 1860             


Leu Asn  Phe Asn Asn Lys Ile  Tyr Tyr Phe Asp Asp  Ser Phe Thr 
    1865                 1870                 1875             


Ala Val  Val Gly Trp Lys Asp  Leu Glu Asp Gly Ser  Lys Tyr Tyr 
    1880                 1885                 1890             


Phe Asp  Glu Asp Thr Ala Glu  Ala Tyr Ile Gly Leu  Ser Leu Ile 
    1895                 1900                 1905             


Asn Asp  Gly Gln Tyr Tyr Phe  Asn Asp Asp Gly Ile  Met Gln Val 
    1910                 1915                 1920             


Gly Phe  Val Thr Ile Asn Asp  Lys Val Phe Tyr Phe  Ser Asp Ser 
    1925                 1930                 1935             


Gly Ile  Ile Glu Ser Gly Val  Gln Asn Ile Asp Asp  Asn Tyr Phe 
    1940                 1945                 1950             


Tyr Ile  Asp Asp Asn Gly Ile  Val Gln Ile Gly Val  Phe Asp Thr 
    1955                 1960                 1965             


Ser Asp  Gly Tyr Lys Tyr Phe  Ala Pro Ala Asn Thr  Val Asn Asp 
    1970                 1975                 1980             


Asn Ile  Tyr Gly Gln Ala Val  Glu Tyr Ser Gly Leu  Val Arg Val 
    1985                 1990                 1995             


Gly Glu  Asp Val Tyr Tyr Phe  Gly Glu Thr Tyr Thr  Ile Glu Thr 
    2000                 2005                 2010             


Gly Trp  Ile Tyr Asp Met Glu  Asn Glu Ser Asp Lys  Tyr Tyr Phe 
    2015                 2020                 2025             


Asn Pro  Glu Thr Lys Lys Ala  Cys Lys Gly Ile Asn  Leu Ile Asp 
    2030                 2035                 2040             


Asp Ile  Lys Tyr Tyr Phe Asp  Glu Lys Gly Ile Met  Arg Thr Gly 
    2045                 2050                 2055             


Leu Ile  Ser Phe Glu Asn Asn  Asn Tyr Tyr Phe Asn  Glu Asn Gly 
    2060                 2065                 2070             


Glu Met  Gln Phe Gly Tyr Ile  Asn Ile Glu Asp Lys  Met Phe Tyr 
    2075                 2080                 2085             


Phe Gly  Glu Asp Gly Val Met  Gln Ile Gly Val Phe  Asn Thr Pro 
    2090                 2095                 2100             


Asp Gly  Phe Lys Tyr Phe Ala  His Gln Asn Thr Leu  Asp Glu Asn 
    2105                 2110                 2115             


Phe Glu  Gly Glu Ser Ile Asn  Tyr Thr Gly Trp Leu  Asp Leu Asp 
    2120                 2125                 2130             


Glu Lys  Arg Tyr Tyr Phe Thr  Asp Glu Tyr Ile Ala  Ala Thr Gly 
    2135                 2140                 2145             


Ser Val  Ile Ile Asp Gly Glu  Glu Tyr Tyr Phe Asp  Pro Asp Thr 
    2150                 2155                 2160             


Ala Gln  Leu Val Ile Ser Glu  
    2165                 2170 


<210>  47
<211>  2157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  47

His His His His His His Ser His Met Ala Ser Asn Lys Glu Ile Leu 
1               5                   10                  15      


Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu Pro Arg Glu Lys 
            20                  25                  30          


Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala Thr Lys Lys Lys 
        35                  40                  45              


Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp Arg Lys Ser Gly 
    50                  55                  60                  


Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp Glu Val Thr Gln 
65                  70                  75                  80  


Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr Glu Asp Glu Ser 
                85                  90                  95      


Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu Ser Val Thr Phe 
            100                 105                 110         


Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile Val Gln Lys Val 
        115                 120                 125             


Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe Arg Glu His Glu 
    130                 135                 140                 


Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn Arg Asp Asn Ile 
145                 150                 155                 160 


Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile Leu Arg Glu Asp 
                165                 170                 175     


Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg Val Arg Gly Val 
            180                 185                 190         


Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln Leu Phe Val Thr 
        195                 200                 205             


Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg Ile Glu Val Pro 
    210                 215                 220                 


Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala Ala Arg Asp Pro 
225                 230                 235                 240 


Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp Lys Arg Ile Asp 
                245                 250                 255     


Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg Val Gln Ala Val 
            260                 265                 270         


Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val Leu Trp Asp Asp 
        275                 280                 285             


Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro Ala Asp Val Ala 
    290                 295                 300                 


Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp Ile Ala Val Glu 
305                 310                 315                 320 


Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly Gln Asn Val Arg 
                325                 330                 335     


Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val Met Thr Val Asp 
            340                 345                 350         


Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala Ala Ile Asp Thr 
        355                 360                 365             


Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala Thr Val Leu Val 
    370                 375                 380                 


Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr Val Pro Met Lys 
385                 390                 395                 400 


Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr Val Glu Ala Leu 
                405                 410                 415     


Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala Gln Ala Gln Glu 
            420                 425                 430         


Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu Leu Asn Leu Glu 
        435                 440                 445             


Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala Arg Gly Val Cys 
    450                 455                 460                 


Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp Leu Ala Asp Ile 
465                 470                 475                 480 


Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile Met Ala Ala Arg 
                485                 490                 495     


Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala Leu Leu Ala Glu 
            500                 505                 510         


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
        515                 520                 525             


Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Ala Gly Gly Ser Leu Val 
    530                 535                 540                 


Pro Arg Gly Ser Gly Ser Ala Ala Ala Pro Phe Thr Met Ser Ile Ile 
545                 550                 555                 560 


Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn 
                565                 570                 575     


Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu 
            580                 585                 590         


Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu 
        595                 600                 605             


Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp 
    610                 615                 620                 


Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser 
625                 630                 635                 640 


Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile 
                645                 650                 655     


Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser 
            660                 665                 670         


His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser 
        675                 680                 685             


Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr 
    690                 695                 700                 


Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile 
705                 710                 715                 720 


Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val 
                725                 730                 735     


Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala 
            740                 745                 750         


Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser 
        755                 760                 765             


Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu 
    770                 775                 780                 


Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu 
785                 790                 795                 800 


Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr Leu 
                805                 810                 815     


Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val Ser Leu 
            820                 825                 830         


Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro Leu Leu Arg 
        835                 840                 845             


Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val Asn Leu Thr Thr 
    850                 855                 860                 


Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly Ile Ala Ser Gly Phe 
865                 870                 875                 880 


Ser Ile Leu Leu Val Pro Leu Ala Gly Ile Ser Ala Gly Ile Pro Ser 
                885                 890                 895     


Leu Val Asn Asn Glu Leu Val Leu Arg Asp Lys Ala Thr Lys Val Val 
            900                 905                 910         


Asp Tyr Phe Lys His Val Ser Leu Val Glu Thr Glu Gly Val Phe Thr 
        915                 920                 925             


Leu Leu Asp Asp Lys Ile Met Met Pro Gln Asp Asp Leu Val Ile Ser 
    930                 935                 940                 


Glu Ile Asp Phe Asn Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile 
945                 950                 955                 960 


Trp Arg Met Glu Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp 
                965                 970                 975     


His Phe Phe Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser 
            980                 985                 990         


Ile Tyr Asp Val Leu Glu Val Gln  Lys Glu Glu Leu Asp  Leu Ser Lys 
        995                 1000                 1005             


Asp Leu  Met Val Leu Pro Asn  Ala Pro Asn Arg Val  Phe Ala Trp 
    1010                 1015                 1020             


Glu Thr  Gly Trp Thr Pro Gly  Leu Arg Ser Leu Glu  Asn Asp Gly 
    1025                 1030                 1035             


Thr Lys  Leu Leu Asp Arg Ile  Arg Asp Asn Tyr Glu  Gly Glu Phe 
    1040                 1045                 1050             


Tyr Trp  Arg Tyr Phe Ala Phe  Ile Ala Asp Ala Leu  Ile Thr Thr 
    1055                 1060                 1065             


Leu Lys  Pro Arg Tyr Glu Asp  Thr Asn Ile Arg Ile  Asn Leu Asp 
    1070                 1075                 1080             


Ser Asn  Thr Arg Ser Phe Ile  Val Pro Ile Ile Thr  Thr Glu Tyr 
    1085                 1090                 1095             


Ile Arg  Glu Lys Leu Ser Tyr  Ser Phe Tyr Gly Ser  Gly Gly Thr 
    1100                 1105                 1110             


Tyr Ala  Leu Ser Leu Ser Gln  Tyr Asn Met Gly Ile  Asn Ile Glu 
    1115                 1120                 1125             


Leu Ser  Glu Ser Asp Val Trp  Ile Ile Asp Val Asp  Asn Val Val 
    1130                 1135                 1140             


Arg Asp  Val Thr Ile Glu Ser  Asp Lys Ile Lys Lys  Gly Asp Leu 
    1145                 1150                 1155             


Ile Glu  Gly Ile Leu Ser Thr  Leu Ser Ile Glu Glu  Asn Lys Ile 
    1160                 1165                 1170             


Ile Leu  Asn Ser His Glu Ile  Asn Phe Ser Gly Glu  Val Asn Gly 
    1175                 1180                 1185             


Ser Asn  Gly Phe Val Ser Leu  Thr Phe Ser Ile Leu  Glu Gly Ile 
    1190                 1195                 1200             


Asn Ala  Ile Ile Glu Val Asp  Leu Leu Ser Lys Ser  Tyr Lys Leu 
    1205                 1210                 1215             


Leu Ile  Ser Gly Glu Leu Lys  Ile Leu Met Leu Asn  Ser Asn His 
    1220                 1225                 1230             


Ile Gln  Gln Lys Ile Asp Tyr  Ile Gly Phe Asn Ser  Glu Leu Gln 
    1235                 1240                 1245             


Lys Asn  Ile Pro Tyr Ser Phe  Val Asp Ser Glu Gly  Lys Glu Asn 
    1250                 1255                 1260             


Gly Phe  Ile Asn Gly Ser Thr  Lys Glu Gly Leu Phe  Val Ser Glu 
    1265                 1270                 1275             


Leu Pro  Asp Val Val Leu Ile  Ser Lys Val Tyr Met  Asp Asp Ser 
    1280                 1285                 1290             


Lys Pro  Ser Phe Gly Tyr Tyr  Ser Asn Asn Leu Lys  Asp Val Lys 
    1295                 1300                 1305             


Val Ile  Thr Lys Asp Asn Val  Asn Ile Leu Thr Gly  Tyr Tyr Leu 
    1310                 1315                 1320             


Lys Asp  Asp Ile Lys Ile Ser  Leu Ser Leu Thr Leu  Gln Asp Glu 
    1325                 1330                 1335             


Lys Thr  Ile Lys Leu Asn Ser  Val His Leu Asp Glu  Ser Gly Val 
    1340                 1345                 1350             


Ala Glu  Ile Leu Lys Phe Met  Asn Arg Lys Gly Asn  Thr Asn Thr 
    1355                 1360                 1365             


Ser Asp  Ser Leu Met Ser Phe  Leu Glu Ser Met Asn  Ile Lys Ser 
    1370                 1375                 1380             


Ile Phe  Val Asn Phe Leu Gln  Ser Asn Ile Lys Phe  Ile Leu Asp 
    1385                 1390                 1395             


Ala Asn  Phe Ile Ile Ser Gly  Thr Thr Ser Ile Gly  Gln Phe Glu 
    1400                 1405                 1410             


Phe Ile  Cys Asp Glu Asn Asp  Asn Ile Gln Pro Tyr  Phe Ile Lys 
    1415                 1420                 1425             


Phe Asn  Thr Leu Glu Thr Asn  Tyr Thr Leu Tyr Val  Gly Asn Arg 
    1430                 1435                 1440             


Gln Asn  Met Ile Val Glu Pro  Asn Tyr Asp Leu Asp  Asp Ser Gly 
    1445                 1450                 1455             


Asp Ile  Ser Ser Thr Val Ile  Asn Phe Ser Gln Lys  Tyr Leu Tyr 
    1460                 1465                 1470             


Gly Ile  Asp Ser Cys Val Asn  Lys Val Val Ile Ser  Pro Asn Ile 
    1475                 1480                 1485             


Tyr Thr  Asp Glu Ile Asn Ile  Thr Pro Val Tyr Glu  Thr Asn Asn 
    1490                 1495                 1500             


Thr Tyr  Pro Glu Val Ile Val  Leu Asp Ala Asn Tyr  Ile Asn Glu 
    1505                 1510                 1515             


Lys Ile  Asn Val Asn Ile Asn  Asp Leu Ser Ile Arg  Tyr Val Trp 
    1520                 1525                 1530             


Ser Asn  Asp Gly Asn Asp Phe  Ile Leu Met Ser Thr  Ser Glu Glu 
    1535                 1540                 1545             


Asn Lys  Val Ser Gln Val Lys  Ile Arg Phe Val Asn  Val Phe Lys 
    1550                 1555                 1560             


Asp Lys  Thr Leu Ala Asn Lys  Leu Ser Phe Asn Phe  Ser Asp Lys 
    1565                 1570                 1575             


Gln Asp  Val Pro Val Ser Glu  Ile Ile Leu Ser Phe  Thr Pro Ser 
    1580                 1585                 1590             


Tyr Tyr  Glu Asp Gly Leu Ile  Gly Tyr Asp Leu Gly  Leu Val Ser 
    1595                 1600                 1605             


Leu Tyr  Asn Glu Lys Phe Tyr  Ile Asn Asn Phe Gly  Met Met Val 
    1610                 1615                 1620             


Ser Gly  Leu Ile Tyr Ile Asn  Asp Ser Leu Tyr Tyr  Phe Lys Pro 
    1625                 1630                 1635             


Pro Val  Asn Asn Leu Ile Thr  Gly Phe Val Thr Val  Gly Asp Asp 
    1640                 1645                 1650             


Lys Tyr  Tyr Phe Asn Pro Ile  Asn Gly Gly Ala Ala  Ser Ile Gly 
    1655                 1660                 1665             


Glu Thr  Ile Ile Asp Asp Lys  Asn Tyr Tyr Phe Asn  Gln Ser Gly 
    1670                 1675                 1680             


Val Leu  Gln Thr Gly Val Phe  Ser Thr Glu Asp Gly  Phe Lys Tyr 
    1685                 1690                 1695             


Phe Ala  Pro Ala Asn Thr Leu  Asp Glu Asn Leu Glu  Gly Glu Ala 
    1700                 1705                 1710             


Ile Asp  Phe Thr Gly Lys Leu  Ile Ile Asp Glu Asn  Ile Tyr Tyr 
    1715                 1720                 1725             


Phe Asp  Asp Asn Tyr Arg Gly  Ala Val Glu Trp Lys  Glu Leu Asp 
    1730                 1735                 1740             


Gly Glu  Met His Tyr Phe Ser  Pro Glu Thr Gly Lys  Ala Phe Lys 
    1745                 1750                 1755             


Gly Leu  Asn Gln Ile Gly Asp  Tyr Lys Tyr Tyr Phe  Asn Ser Asp 
    1760                 1765                 1770             


Gly Val  Met Gln Lys Gly Phe  Val Ser Ile Asn Asp  Asn Lys His 
    1775                 1780                 1785             


Tyr Phe  Asp Asp Ser Gly Val  Met Lys Val Gly Tyr  Thr Glu Ile 
    1790                 1795                 1800             


Asp Gly  Lys His Phe Tyr Phe  Ala Glu Asn Gly Glu  Met Gln Ile 
    1805                 1810                 1815             


Gly Val  Phe Asn Thr Glu Asp  Gly Phe Lys Tyr Phe  Ala His His 
    1820                 1825                 1830             


Asn Glu  Asp Leu Gly Asn Glu  Glu Gly Glu Glu Ile  Ser Tyr Ser 
    1835                 1840                 1845             


Gly Ile  Leu Asn Phe Asn Asn  Lys Ile Tyr Tyr Phe  Asp Asp Ser 
    1850                 1855                 1860             


Phe Thr  Ala Val Val Gly Trp  Lys Asp Leu Glu Asp  Gly Ser Lys 
    1865                 1870                 1875             


Tyr Tyr  Phe Asp Glu Asp Thr  Ala Glu Ala Tyr Ile  Gly Leu Ser 
    1880                 1885                 1890             


Leu Ile  Asn Asp Gly Gln Tyr  Tyr Phe Asn Asp Asp  Gly Ile Met 
    1895                 1900                 1905             


Gln Val  Gly Phe Val Thr Ile  Asn Asp Lys Val Phe  Tyr Phe Ser 
    1910                 1915                 1920             


Asp Ser  Gly Ile Ile Glu Ser  Gly Val Gln Asn Ile  Asp Asp Asn 
    1925                 1930                 1935             


Tyr Phe  Tyr Ile Asp Asp Asn  Gly Ile Val Gln Ile  Gly Val Phe 
    1940                 1945                 1950             


Asp Thr  Ser Asp Gly Tyr Lys  Tyr Phe Ala Pro Ala  Asn Thr Val 
    1955                 1960                 1965             


Asn Asp  Asn Ile Tyr Gly Gln  Ala Val Glu Tyr Ser  Gly Leu Val 
    1970                 1975                 1980             


Arg Val  Gly Glu Asp Val Tyr  Tyr Phe Gly Glu Thr  Tyr Thr Ile 
    1985                 1990                 1995             


Glu Thr  Gly Trp Ile Tyr Asp  Met Glu Asn Glu Ser  Asp Lys Tyr 
    2000                 2005                 2010             


Tyr Phe  Asn Pro Glu Thr Lys  Lys Ala Cys Lys Gly  Ile Asn Leu 
    2015                 2020                 2025             


Ile Asp  Asp Ile Lys Tyr Tyr  Phe Asp Glu Lys Gly  Ile Met Arg 
    2030                 2035                 2040             


Thr Gly  Leu Ile Ser Phe Glu  Asn Asn Asn Tyr Tyr  Phe Asn Glu 
    2045                 2050                 2055             


Asn Gly  Glu Met Gln Phe Gly  Tyr Ile Asn Ile Glu  Asp Lys Met 
    2060                 2065                 2070             


Phe Tyr  Phe Gly Glu Asp Gly  Val Met Gln Ile Gly  Val Phe Asn 
    2075                 2080                 2085             


Thr Pro  Asp Gly Phe Lys Tyr  Phe Ala His Gln Asn  Thr Leu Asp 
    2090                 2095                 2100             


Glu Asn  Phe Glu Gly Glu Ser  Ile Asn Tyr Thr Gly  Trp Leu Asp 
    2105                 2110                 2115             


Leu Asp  Glu Lys Arg Tyr Tyr  Phe Thr Asp Glu Tyr  Ile Ala Ala 
    2120                 2125                 2130             


Thr Gly  Ser Val Ile Ile Asp  Gly Glu Glu Tyr Tyr  Phe Asp Pro 
    2135                 2140                 2145             


Asp Thr  Ala Gln Leu Val Ile  Ser Glu 
    2150                 2155         


<210>  48
<211>  1776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  48

His His His His His His His His His His Gly Gly Ser Gly Gly Ser 
1               5                   10                  15      


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
            20                  25                  30          


Gly Ser Gly Gly Ser Gly Gly Ser His Met Ala Ser Asp Lys Ile Ile 
        35                  40                  45              


His Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp Gly 
    50                  55                  60                  


Ala Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys Met 
65                  70                  75                  80  


Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys Leu 
                85                  90                  95      


Thr Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro Lys 
            100                 105                 110         


Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly Glu 
        115                 120                 125             


Val Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys Glu 
    130                 135                 140                 


Phe Leu Asp Ala Asn Leu Ala Arg Ala Leu Val Pro Arg Gly Ser Val 
145                 150                 155                 160 


Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Ala Pro Phe Thr Met 
                165                 170                 175     


Ser Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro 
            180                 185                 190         


Lys Glu Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser 
        195                 200                 205             


Thr Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu 
    210                 215                 220                 


Leu Glu Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser 
225                 230                 235                 240 


Asn Ile Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn 
                245                 250                 255     


Leu Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile 
            260                 265                 270         


Glu Ser Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu 
        275                 280                 285             


Glu Asp Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu 
    290                 295                 300                 


Gly Phe Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe 
305                 310                 315                 320 


Val Glu Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr 
                325                 330                 335     


Glu Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly 
            340                 345                 350         


Lys Leu Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr 
        355                 360                 365             


Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser 
    370                 375                 380                 


Lys Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr 
385                 390                 395                 400 


Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys 
                405                 410                 415     


Val Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu 
            420                 425                 430         


Pro Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly 
        435                 440                 445             


Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro 
    450                 455                 460                 


Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val Asn 
465                 470                 475                 480 


Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly Ile Ala 
                485                 490                 495     


Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile Ser Ala Gly 
            500                 505                 510         


Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg Asp Lys Ala Thr 
        515                 520                 525             


Lys Val Val Asp Tyr Phe Lys His Val Ser Leu Val Glu Thr Glu Gly 
    530                 535                 540                 


Val Phe Thr Leu Leu Asp Asp Lys Ile Met Met Pro Gln Asp Asp Leu 
545                 550                 555                 560 


Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Val Leu Gly Lys 
                565                 570                 575     


Cys Glu Ile Trp Arg Met Glu Gly Gly Ser Gly His Thr Val Thr Asp 
            580                 585                 590         


Asp Ile Asp His Phe Phe Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro 
        595                 600                 605             


His Leu Ser Ile Tyr Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp 
    610                 615                 620                 


Leu Ser Lys Asp Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe 
625                 630                 635                 640 


Ala Trp Glu Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp 
                645                 650                 655     


Gly Thr Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe 
            660                 665                 670         


Tyr Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu 
        675                 680                 685             


Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn 
    690                 695                 700                 


Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg Glu 
705                 710                 715                 720 


Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala Leu Ser 
                725                 730                 735     


Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser Glu Ser Asp 
            740                 745                 750         


Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp Val Thr Ile Glu 
        755                 760                 765             


Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu Gly Ile Leu Ser Thr 
    770                 775                 780                 


Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu Asn Ser His Glu Ile Asn 
785                 790                 795                 800 


Phe Ser Gly Glu Val Asn Gly Ser Asn Gly Phe Val Ser Leu Thr Phe 
                805                 810                 815     


Ser Ile Leu Glu Gly Ile Asn Ala Ile Ile Glu Val Asp Leu Leu Ser 
            820                 825                 830         


Lys Ser Tyr Lys Leu Leu Ile Ser Gly Glu Leu Lys Ile Leu Met Leu 
        835                 840                 845             


Asn Ser Asn His Ile Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser 
    850                 855                 860                 


Glu Leu Gln Lys Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys 
865                 870                 875                 880 


Glu Asn Gly Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser 
                885                 890                 895     


Glu Leu Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser 
            900                 905                 910         


Lys Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val 
        915                 920                 925             


Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp 
    930                 935                 940                 


Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr Ile 
945                 950                 955                 960 


Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu Ile Leu 
                965                 970                 975     


Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp Ser Leu Met 
            980                 985                 990         


Ser Phe Leu Glu Ser Met Asn Ile  Lys Ser Ile Phe Val  Asn Phe Leu 
        995                 1000                 1005             


Gln Ser  Asn Ile Lys Phe Ile  Leu Asp Ala Asn Phe  Ile Ile Ser 
    1010                 1015                 1020             


Gly Thr  Thr Ser Ile Gly Gln  Phe Glu Phe Ile Cys  Asp Glu Asn 
    1025                 1030                 1035             


Asp Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe Asn Thr  Leu Glu Thr 
    1040                 1045                 1050             


Asn Tyr  Thr Leu Tyr Val Gly  Asn Arg Gln Asn Met  Ile Val Glu 
    1055                 1060                 1065             


Pro Asn  Tyr Asp Leu Asp Asp  Ser Gly Asp Ile Ser  Ser Thr Val 
    1070                 1075                 1080             


Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly Ile Asp  Ser Cys Val 
    1085                 1090                 1095             


Asn Lys  Val Val Ile Ser Pro  Asn Ile Tyr Thr Asp  Glu Ile Asn 
    1100                 1105                 1110             


Ile Thr  Pro Val Tyr Glu Thr  Asn Asn Thr Tyr Pro  Glu Val Ile 
    1115                 1120                 1125             


Val Leu  Asp Ala Asn Tyr Ile  Asn Glu Lys Ile Asn  Val Asn Ile 
    1130                 1135                 1140             


Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser Asn Asp  Gly Asn Asp 
    1145                 1150                 1155             


Phe Ile  Leu Met Ser Thr Ser  Glu Glu Asn Lys Val  Ser Gln Val 
    1160                 1165                 1170             


Lys Ile  Arg Phe Val Asn Val  Phe Lys Asp Lys Thr  Leu Ala Asn 
    1175                 1180                 1185             


Lys Leu  Ser Phe Asn Phe Ser  Asp Lys Gln Asp Val  Pro Val Ser 
    1190                 1195                 1200             


Glu Ile  Ile Leu Ser Phe Thr  Pro Ser Tyr Tyr Glu  Asp Gly Leu 
    1205                 1210                 1215             


Ile Gly  Tyr Asp Leu Gly Leu  Val Ser Leu Tyr Asn  Glu Lys Phe 
    1220                 1225                 1230             


Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser Gly Leu  Ile Tyr Ile 
    1235                 1240                 1245             


Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro Val Asn  Asn Leu Ile 
    1250                 1255                 1260             


Thr Gly  Phe Val Thr Val Gly  Asp Asp Lys Tyr Tyr  Phe Asn Pro 
    1265                 1270                 1275             


Ile Asn  Gly Gly Ala Ala Ser  Ile Gly Glu Thr Ile  Ile Asp Asp 
    1280                 1285                 1290             


Lys Asn  Tyr Tyr Phe Asn Gln  Ser Gly Val Leu Gln  Thr Gly Val 
    1295                 1300                 1305             


Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe Ala Pro  Ala Asn Thr 
    1310                 1315                 1320             


Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile Asp Phe  Thr Gly Lys 
    1325                 1330                 1335             


Leu Ile  Ile Asp Glu Asn Ile  Tyr Tyr Phe Asp Asp  Asn Tyr Arg 
    1340                 1345                 1350             


Gly Ala  Val Glu Trp Lys Glu  Leu Asp Gly Glu Met  His Tyr Phe 
    1355                 1360                 1365             


Ser Pro  Glu Thr Gly Lys Ala  Phe Lys Gly Leu Asn  Gln Ile Gly 
    1370                 1375                 1380             


Asp Tyr  Lys Tyr Tyr Phe Asn  Ser Asp Gly Val Met  Gln Lys Gly 
    1385                 1390                 1395             


Phe Val  Ser Ile Asn Asp Asn  Lys His Tyr Phe Asp  Asp Ser Gly 
    1400                 1405                 1410             


Val Met  Lys Val Gly Tyr Thr  Glu Ile Asp Gly Lys  His Phe Tyr 
    1415                 1420                 1425             


Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly Val Phe  Asn Thr Glu 
    1430                 1435                 1440             


Asp Gly  Phe Lys Tyr Phe Ala  His His Asn Glu Asp  Leu Gly Asn 
    1445                 1450                 1455             


Glu Glu  Gly Glu Glu Ile Ser  Tyr Ser Gly Ile Leu  Asn Phe Asn 
    1460                 1465                 1470             


Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe Thr Ala  Val Val Gly 
    1475                 1480                 1485             


Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr Tyr Phe  Asp Glu Asp 
    1490                 1495                 1500             


Thr Ala  Glu Ala Tyr Ile Gly  Leu Ser Leu Ile Asn  Asp Gly Gln 
    1505                 1510                 1515             


Tyr Tyr  Phe Asn Asp Asp Gly  Ile Met Gln Val Gly  Phe Val Thr 
    1520                 1525                 1530             


Ile Asn  Asp Lys Val Phe Tyr  Phe Ser Asp Ser Gly  Ile Ile Glu 
    1535                 1540                 1545             


Ser Gly  Val Gln Asn Ile Asp  Asp Asn Tyr Phe Tyr  Ile Asp Asp 
    1550                 1555                 1560             


Asn Gly  Ile Val Gln Ile Gly  Val Phe Asp Thr Ser  Asp Gly Tyr 
    1565                 1570                 1575             


Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn Asp Asn  Ile Tyr Gly 
    1580                 1585                 1590             


Gln Ala  Val Glu Tyr Ser Gly  Leu Val Arg Val Gly  Glu Asp Val 
    1595                 1600                 1605             


Tyr Tyr  Phe Gly Glu Thr Tyr  Thr Ile Glu Thr Gly  Trp Ile Tyr 
    1610                 1615                 1620             


Asp Met  Glu Asn Glu Ser Asp  Lys Tyr Tyr Phe Asn  Pro Glu Thr 
    1625                 1630                 1635             


Lys Lys  Ala Cys Lys Gly Ile  Asn Leu Ile Asp Asp  Ile Lys Tyr 
    1640                 1645                 1650             


Tyr Phe  Asp Glu Lys Gly Ile  Met Arg Thr Gly Leu  Ile Ser Phe 
    1655                 1660                 1665             


Glu Asn  Asn Asn Tyr Tyr Phe  Asn Glu Asn Gly Glu  Met Gln Phe 
    1670                 1675                 1680             


Gly Tyr  Ile Asn Ile Glu Asp  Lys Met Phe Tyr Phe  Gly Glu Asp 
    1685                 1690                 1695             


Gly Val  Met Gln Ile Gly Val  Phe Asn Thr Pro Asp  Gly Phe Lys 
    1700                 1705                 1710             


Tyr Phe  Ala His Gln Asn Thr  Leu Asp Glu Asn Phe  Glu Gly Glu 
    1715                 1720                 1725             


Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu Asp Glu  Lys Arg Tyr 
    1730                 1735                 1740             


Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr Gly Ser  Val Ile Ile 
    1745                 1750                 1755             


Asp Gly  Glu Glu Tyr Tyr Phe  Asp Pro Asp Thr Ala  Gln Leu Val 
    1760                 1765                 1770             


Ile Ser  Glu 
    1775     


<210>  49
<211>  1763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  49

His His His His His His Ser His Met Ala Ser Asp Lys Ile Ile His 
1               5                   10                  15      


Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp Gly Ala 
            20                  25                  30          


Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys Met Ile 
        35                  40                  45              


Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys Leu Thr 
    50                  55                  60                  


Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro Lys Tyr 
65                  70                  75                  80  


Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly Glu Val 
                85                  90                  95      


Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys Glu Phe 
            100                 105                 110         


Leu Asp Ala Asn Leu Ala Arg Ala Leu Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Ser Ala Ala Ala Pro 
145                 150                 155                 160 


Phe Thr Met Ser Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser 
                165                 170                 175     


Phe Asn Pro Lys Glu Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro 
            180                 185                 190         


Glu Leu Ser Thr Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser 
        195                 200                 205             


Asp Ile Glu Leu Glu Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn 
    210                 215                 220                 


Val Ile Ser Asn Ile Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu 
225                 230                 235                 240 


Ala Lys Asn Leu Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe 
                245                 250                 255     


Lys Leu Ile Glu Ser Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln 
            260                 265                 270         


Asn Glu Leu Glu Asp Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu 
        275                 280                 285             


Thr Asp Glu Gly Phe Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu 
    290                 295                 300                 


Ser Ile Phe Val Glu Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn 
305                 310                 315                 320 


His Ile Thr Glu Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr 
                325                 330                 335     


Val Asn Gly Lys Leu Val Lys Lys Val Asn Leu Asp Thr Thr His Glu 
            340                 345                 350         


Val Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr 
        355                 360                 365             


Asn Ser Ser Lys Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val 
    370                 375                 380                 


Gln Val Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp 
385                 390                 395                 400 


Ala Ala Lys Val Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile 
                405                 410                 415     


Asp Leu Leu Pro Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile 
            420                 425                 430         


Ile Asp Gly Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr 
        435                 440                 445             


Ser Asp Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met 
    450                 455                 460                 


Ala Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu 
465                 470                 475                 480 


Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile 
                485                 490                 495     


Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg Asp 
            500                 505                 510         


Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu Val Glu 
        515                 520                 525             


Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met Met Pro Gln 
    530                 535                 540                 


Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Val 
545                 550                 555                 560 


Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly Gly Ser Gly His Thr 
                565                 570                 575     


Val Thr Asp Asp Ile Asp His Phe Phe Ser Ala Pro Ser Ile Thr Tyr 
            580                 585                 590         


Arg Glu Pro His Leu Ser Ile Tyr Asp Val Leu Glu Val Gln Lys Glu 
        595                 600                 605             


Glu Leu Asp Leu Ser Lys Asp Leu Met Val Leu Pro Asn Ala Pro Asn 
    610                 615                 620                 


Arg Val Phe Ala Trp Glu Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu 
625                 630                 635                 640 


Glu Asn Asp Gly Thr Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu 
                645                 650                 655     


Gly Glu Phe Tyr Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile 
            660                 665                 670         


Thr Thr Leu Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu 
        675                 680                 685             


Asp Ser Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr 
    690                 695                 700                 


Ile Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr 
705                 710                 715                 720 


Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser 
                725                 730                 735     


Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp Val 
            740                 745                 750         


Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu Gly Ile 
        755                 760                 765             


Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu Asn Ser His 
    770                 775                 780                 


Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn Gly Phe Val Ser 
785                 790                 795                 800 


Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala Ile Ile Glu Val Asp 
                805                 810                 815     


Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile Ser Gly Glu Leu Lys Ile 
            820                 825                 830         


Leu Met Leu Asn Ser Asn His Ile Gln Gln Lys Ile Asp Tyr Ile Gly 
        835                 840                 845             


Phe Asn Ser Glu Leu Gln Lys Asn Ile Pro Tyr Ser Phe Val Asp Ser 
    850                 855                 860                 


Glu Gly Lys Glu Asn Gly Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu 
865                 870                 875                 880 


Phe Val Ser Glu Leu Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met 
                885                 890                 895     


Asp Asp Ser Lys Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp 
            900                 905                 910         


Val Lys Val Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr 
        915                 920                 925             


Leu Lys Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu 
    930                 935                 940                 


Lys Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala 
945                 950                 955                 960 


Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp 
                965                 970                 975     


Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe Val 
            980                 985                 990         


Asn Phe Leu Gln Ser Asn Ile Lys  Phe Ile Leu Asp Ala  Asn Phe Ile 
        995                 1000                 1005             


Ile Ser  Gly Thr Thr Ser Ile  Gly Gln Phe Glu Phe  Ile Cys Asp 
    1010                 1015                 1020             


Glu Asn  Asp Asn Ile Gln Pro  Tyr Phe Ile Lys Phe  Asn Thr Leu 
    1025                 1030                 1035             


Glu Thr  Asn Tyr Thr Leu Tyr  Val Gly Asn Arg Gln  Asn Met Ile 
    1040                 1045                 1050             


Val Glu  Pro Asn Tyr Asp Leu  Asp Asp Ser Gly Asp  Ile Ser Ser 
    1055                 1060                 1065             


Thr Val  Ile Asn Phe Ser Gln  Lys Tyr Leu Tyr Gly  Ile Asp Ser 
    1070                 1075                 1080             


Cys Val  Asn Lys Val Val Ile  Ser Pro Asn Ile Tyr  Thr Asp Glu 
    1085                 1090                 1095             


Ile Asn  Ile Thr Pro Val Tyr  Glu Thr Asn Asn Thr  Tyr Pro Glu 
    1100                 1105                 1110             


Val Ile  Val Leu Asp Ala Asn  Tyr Ile Asn Glu Lys  Ile Asn Val 
    1115                 1120                 1125             


Asn Ile  Asn Asp Leu Ser Ile  Arg Tyr Val Trp Ser  Asn Asp Gly 
    1130                 1135                 1140             


Asn Asp  Phe Ile Leu Met Ser  Thr Ser Glu Glu Asn  Lys Val Ser 
    1145                 1150                 1155             


Gln Val  Lys Ile Arg Phe Val  Asn Val Phe Lys Asp  Lys Thr Leu 
    1160                 1165                 1170             


Ala Asn  Lys Leu Ser Phe Asn  Phe Ser Asp Lys Gln  Asp Val Pro 
    1175                 1180                 1185             


Val Ser  Glu Ile Ile Leu Ser  Phe Thr Pro Ser Tyr  Tyr Glu Asp 
    1190                 1195                 1200             


Gly Leu  Ile Gly Tyr Asp Leu  Gly Leu Val Ser Leu  Tyr Asn Glu 
    1205                 1210                 1215             


Lys Phe  Tyr Ile Asn Asn Phe  Gly Met Met Val Ser  Gly Leu Ile 
    1220                 1225                 1230             


Tyr Ile  Asn Asp Ser Leu Tyr  Tyr Phe Lys Pro Pro  Val Asn Asn 
    1235                 1240                 1245             


Leu Ile  Thr Gly Phe Val Thr  Val Gly Asp Asp Lys  Tyr Tyr Phe 
    1250                 1255                 1260             


Asn Pro  Ile Asn Gly Gly Ala  Ala Ser Ile Gly Glu  Thr Ile Ile 
    1265                 1270                 1275             


Asp Asp  Lys Asn Tyr Tyr Phe  Asn Gln Ser Gly Val  Leu Gln Thr 
    1280                 1285                 1290             


Gly Val  Phe Ser Thr Glu Asp  Gly Phe Lys Tyr Phe  Ala Pro Ala 
    1295                 1300                 1305             


Asn Thr  Leu Asp Glu Asn Leu  Glu Gly Glu Ala Ile  Asp Phe Thr 
    1310                 1315                 1320             


Gly Lys  Leu Ile Ile Asp Glu  Asn Ile Tyr Tyr Phe  Asp Asp Asn 
    1325                 1330                 1335             


Tyr Arg  Gly Ala Val Glu Trp  Lys Glu Leu Asp Gly  Glu Met His 
    1340                 1345                 1350             


Tyr Phe  Ser Pro Glu Thr Gly  Lys Ala Phe Lys Gly  Leu Asn Gln 
    1355                 1360                 1365             


Ile Gly  Asp Tyr Lys Tyr Tyr  Phe Asn Ser Asp Gly  Val Met Gln 
    1370                 1375                 1380             


Lys Gly  Phe Val Ser Ile Asn  Asp Asn Lys His Tyr  Phe Asp Asp 
    1385                 1390                 1395             


Ser Gly  Val Met Lys Val Gly  Tyr Thr Glu Ile Asp  Gly Lys His 
    1400                 1405                 1410             


Phe Tyr  Phe Ala Glu Asn Gly  Glu Met Gln Ile Gly  Val Phe Asn 
    1415                 1420                 1425             


Thr Glu  Asp Gly Phe Lys Tyr  Phe Ala His His Asn  Glu Asp Leu 
    1430                 1435                 1440             


Gly Asn  Glu Glu Gly Glu Glu  Ile Ser Tyr Ser Gly  Ile Leu Asn 
    1445                 1450                 1455             


Phe Asn  Asn Lys Ile Tyr Tyr  Phe Asp Asp Ser Phe  Thr Ala Val 
    1460                 1465                 1470             


Val Gly  Trp Lys Asp Leu Glu  Asp Gly Ser Lys Tyr  Tyr Phe Asp 
    1475                 1480                 1485             


Glu Asp  Thr Ala Glu Ala Tyr  Ile Gly Leu Ser Leu  Ile Asn Asp 
    1490                 1495                 1500             


Gly Gln  Tyr Tyr Phe Asn Asp  Asp Gly Ile Met Gln  Val Gly Phe 
    1505                 1510                 1515             


Val Thr  Ile Asn Asp Lys Val  Phe Tyr Phe Ser Asp  Ser Gly Ile 
    1520                 1525                 1530             


Ile Glu  Ser Gly Val Gln Asn  Ile Asp Asp Asn Tyr  Phe Tyr Ile 
    1535                 1540                 1545             


Asp Asp  Asn Gly Ile Val Gln  Ile Gly Val Phe Asp  Thr Ser Asp 
    1550                 1555                 1560             


Gly Tyr  Lys Tyr Phe Ala Pro  Ala Asn Thr Val Asn  Asp Asn Ile 
    1565                 1570                 1575             


Tyr Gly  Gln Ala Val Glu Tyr  Ser Gly Leu Val Arg  Val Gly Glu 
    1580                 1585                 1590             


Asp Val  Tyr Tyr Phe Gly Glu  Thr Tyr Thr Ile Glu  Thr Gly Trp 
    1595                 1600                 1605             


Ile Tyr  Asp Met Glu Asn Glu  Ser Asp Lys Tyr Tyr  Phe Asn Pro 
    1610                 1615                 1620             


Glu Thr  Lys Lys Ala Cys Lys  Gly Ile Asn Leu Ile  Asp Asp Ile 
    1625                 1630                 1635             


Lys Tyr  Tyr Phe Asp Glu Lys  Gly Ile Met Arg Thr  Gly Leu Ile 
    1640                 1645                 1650             


Ser Phe  Glu Asn Asn Asn Tyr  Tyr Phe Asn Glu Asn  Gly Glu Met 
    1655                 1660                 1665             


Gln Phe  Gly Tyr Ile Asn Ile  Glu Asp Lys Met Phe  Tyr Phe Gly 
    1670                 1675                 1680             


Glu Asp  Gly Val Met Gln Ile  Gly Val Phe Asn Thr  Pro Asp Gly 
    1685                 1690                 1695             


Phe Lys  Tyr Phe Ala His Gln  Asn Thr Leu Asp Glu  Asn Phe Glu 
    1700                 1705                 1710             


Gly Glu  Ser Ile Asn Tyr Thr  Gly Trp Leu Asp Leu  Asp Glu Lys 
    1715                 1720                 1725             


Arg Tyr  Tyr Phe Thr Asp Glu  Tyr Ile Ala Ala Thr  Gly Ser Val 
    1730                 1735                 1740             


Ile Ile  Asp Gly Glu Glu Tyr  Tyr Phe Asp Pro Asp  Thr Ala Gln 
    1745                 1750                 1755             


Leu Val  Ile Ser Glu 
    1760             


<210>  50
<211>  1782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  50

His His His His His His His His His His Gly Gly Ser Leu Ala Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Ala Gly Gly Ser His Met 
        35                  40                  45              


Ala Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
    50                  55                  60                  


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
65                  70                  75                  80  


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
                85                  90                  95      


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
            100                 105                 110         


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
        115                 120                 125             


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
    130                 135                 140                 


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Arg Ala Leu 
145                 150                 155                 160 


Val Pro Arg Gly Ser Val Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala 
                165                 170                 175     


Ala Ala Pro Phe Thr Met Ser Ile Ile Lys Asp Ile Ser Ser Lys Glu 
            180                 185                 190         


Tyr Ile Ser Phe Asn Pro Lys Glu Asn Lys Ile Thr Val Lys Ser Lys 
        195                 200                 205             


Asn Leu Pro Glu Leu Ser Thr Leu Leu Gln Glu Ile Arg Asn Asn Ser 
    210                 215                 220                 


Asn Ser Ser Asp Ile Glu Leu Glu Glu Lys Val Met Leu Thr Glu Cys 
225                 230                 235                 240 


Glu Ile Asn Val Ile Ser Asn Ile Asp Thr Gln Ile Val Glu Glu Arg 
                245                 250                 255     


Ile Glu Glu Ala Lys Asn Leu Thr Ser Asp Ser Ile Asn Tyr Ile Lys 
            260                 265                 270         


Asp Glu Phe Lys Leu Ile Glu Ser Ile Ser Asp Ala Leu Cys Asp Leu 
        275                 280                 285             


Lys Gln Gln Asn Glu Leu Glu Asp Ser His Phe Ile Ser Phe Glu Asp 
    290                 295                 300                 


Ile Ser Glu Thr Asp Glu Gly Phe Ser Ile Arg Phe Ile Asn Lys Glu 
305                 310                 315                 320 


Thr Gly Glu Ser Ile Phe Val Glu Thr Glu Lys Thr Ile Phe Ser Glu 
                325                 330                 335     


Tyr Ala Asn His Ile Thr Glu Glu Ile Ser Lys Ile Lys Gly Thr Ile 
            340                 345                 350         


Phe Asp Thr Val Asn Gly Lys Leu Val Lys Lys Val Asn Leu Asp Thr 
        355                 360                 365             


Thr His Glu Val Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu 
    370                 375                 380                 


Ile Glu Tyr Asn Ser Ser Lys Glu Ser Leu Ser Asn Leu Ser Val Ala 
385                 390                 395                 400 


Met Lys Val Gln Val Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr 
                405                 410                 415     


Ile Thr Asp Ala Ala Lys Val Val Glu Leu Val Ser Thr Ala Leu Asp 
            420                 425                 430         


Glu Thr Ile Asp Leu Leu Pro Thr Leu Ser Glu Gly Leu Pro Ile Ile 
        435                 440                 445             


Ala Thr Ile Ile Asp Gly Val Ser Leu Gly Ala Ala Ile Lys Glu Leu 
    450                 455                 460                 


Ser Glu Thr Ser Asp Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile 
465                 470                 475                 480 


Gly Ile Met Ala Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr 
                485                 490                 495     


Ser Ser Leu Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu 
            500                 505                 510         


Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val 
        515                 520                 525             


Leu Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser 
    530                 535                 540                 


Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met 
545                 550                 555                 560 


Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn 
                565                 570                 575     


Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly Gly Ser 
            580                 585                 590         


Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser Ala Pro Ser 
        595                 600                 605             


Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp Val Leu Glu Val 
    610                 615                 620                 


Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu Met Val Leu Pro Asn 
625                 630                 635                 640 


Ala Pro Asn Arg Val Phe Ala Trp Glu Thr Gly Trp Thr Pro Gly Leu 
                645                 650                 655     


Arg Ser Leu Glu Asn Asp Gly Thr Lys Leu Leu Asp Arg Ile Arg Asp 
            660                 665                 670         


Asn Tyr Glu Gly Glu Phe Tyr Trp Arg Tyr Phe Ala Phe Ile Ala Asp 
        675                 680                 685             


Ala Leu Ile Thr Thr Leu Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg 
    690                 695                 700                 


Ile Asn Leu Asp Ser Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr 
705                 710                 715                 720 


Thr Glu Tyr Ile Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly 
                725                 730                 735     


Gly Thr Tyr Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile 
            740                 745                 750         


Glu Leu Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val 
        755                 760                 765             


Arg Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile 
    770                 775                 780                 


Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu 
785                 790                 795                 800 


Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn Gly 
                805                 810                 815     


Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala Ile Ile 
            820                 825                 830         


Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile Ser Gly Glu 
        835                 840                 845             


Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln Gln Lys Ile Asp 
    850                 855                 860                 


Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn Ile Pro Tyr Ser Phe 
865                 870                 875                 880 


Val Asp Ser Glu Gly Lys Glu Asn Gly Phe Ile Asn Gly Ser Thr Lys 
                885                 890                 895     


Glu Gly Leu Phe Val Ser Glu Leu Pro Asp Val Val Leu Ile Ser Lys 
            900                 905                 910         


Val Tyr Met Asp Asp Ser Lys Pro Ser Phe Gly Tyr Tyr Ser Asn Asn 
        915                 920                 925             


Leu Lys Asp Val Lys Val Ile Thr Lys Asp Asn Val Asn Ile Leu Thr 
    930                 935                 940                 


Gly Tyr Tyr Leu Lys Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu 
945                 950                 955                 960 


Gln Asp Glu Lys Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser 
                965                 970                 975     


Gly Val Ala Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn 
            980                 985                 990         


Thr Ser Asp Ser Leu Met Ser Phe  Leu Glu Ser Met Asn  Ile Lys Ser 
        995                 1000                 1005             


Ile Phe  Val Asn Phe Leu Gln  Ser Asn Ile Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Ala Asn  Phe Ile Ile Ser Gly  Thr Thr Ser Ile Gly  Gln Phe Glu 
    1025                 1030                 1035             


Phe Ile  Cys Asp Glu Asn Asp  Asn Ile Gln Pro Tyr  Phe Ile Lys 
    1040                 1045                 1050             


Phe Asn  Thr Leu Glu Thr Asn  Tyr Thr Leu Tyr Val  Gly Asn Arg 
    1055                 1060                 1065             


Gln Asn  Met Ile Val Glu Pro  Asn Tyr Asp Leu Asp  Asp Ser Gly 
    1070                 1075                 1080             


Asp Ile  Ser Ser Thr Val Ile  Asn Phe Ser Gln Lys  Tyr Leu Tyr 
    1085                 1090                 1095             


Gly Ile  Asp Ser Cys Val Asn  Lys Val Val Ile Ser  Pro Asn Ile 
    1100                 1105                 1110             


Tyr Thr  Asp Glu Ile Asn Ile  Thr Pro Val Tyr Glu  Thr Asn Asn 
    1115                 1120                 1125             


Thr Tyr  Pro Glu Val Ile Val  Leu Asp Ala Asn Tyr  Ile Asn Glu 
    1130                 1135                 1140             


Lys Ile  Asn Val Asn Ile Asn  Asp Leu Ser Ile Arg  Tyr Val Trp 
    1145                 1150                 1155             


Ser Asn  Asp Gly Asn Asp Phe  Ile Leu Met Ser Thr  Ser Glu Glu 
    1160                 1165                 1170             


Asn Lys  Val Ser Gln Val Lys  Ile Arg Phe Val Asn  Val Phe Lys 
    1175                 1180                 1185             


Asp Lys  Thr Leu Ala Asn Lys  Leu Ser Phe Asn Phe  Ser Asp Lys 
    1190                 1195                 1200             


Gln Asp  Val Pro Val Ser Glu  Ile Ile Leu Ser Phe  Thr Pro Ser 
    1205                 1210                 1215             


Tyr Tyr  Glu Asp Gly Leu Ile  Gly Tyr Asp Leu Gly  Leu Val Ser 
    1220                 1225                 1230             


Leu Tyr  Asn Glu Lys Phe Tyr  Ile Asn Asn Phe Gly  Met Met Val 
    1235                 1240                 1245             


Ser Gly  Leu Ile Tyr Ile Asn  Asp Ser Leu Tyr Tyr  Phe Lys Pro 
    1250                 1255                 1260             


Pro Val  Asn Asn Leu Ile Thr  Gly Phe Val Thr Val  Gly Asp Asp 
    1265                 1270                 1275             


Lys Tyr  Tyr Phe Asn Pro Ile  Asn Gly Gly Ala Ala  Ser Ile Gly 
    1280                 1285                 1290             


Glu Thr  Ile Ile Asp Asp Lys  Asn Tyr Tyr Phe Asn  Gln Ser Gly 
    1295                 1300                 1305             


Val Leu  Gln Thr Gly Val Phe  Ser Thr Glu Asp Gly  Phe Lys Tyr 
    1310                 1315                 1320             


Phe Ala  Pro Ala Asn Thr Leu  Asp Glu Asn Leu Glu  Gly Glu Ala 
    1325                 1330                 1335             


Ile Asp  Phe Thr Gly Lys Leu  Ile Ile Asp Glu Asn  Ile Tyr Tyr 
    1340                 1345                 1350             


Phe Asp  Asp Asn Tyr Arg Gly  Ala Val Glu Trp Lys  Glu Leu Asp 
    1355                 1360                 1365             


Gly Glu  Met His Tyr Phe Ser  Pro Glu Thr Gly Lys  Ala Phe Lys 
    1370                 1375                 1380             


Gly Leu  Asn Gln Ile Gly Asp  Tyr Lys Tyr Tyr Phe  Asn Ser Asp 
    1385                 1390                 1395             


Gly Val  Met Gln Lys Gly Phe  Val Ser Ile Asn Asp  Asn Lys His 
    1400                 1405                 1410             


Tyr Phe  Asp Asp Ser Gly Val  Met Lys Val Gly Tyr  Thr Glu Ile 
    1415                 1420                 1425             


Asp Gly  Lys His Phe Tyr Phe  Ala Glu Asn Gly Glu  Met Gln Ile 
    1430                 1435                 1440             


Gly Val  Phe Asn Thr Glu Asp  Gly Phe Lys Tyr Phe  Ala His His 
    1445                 1450                 1455             


Asn Glu  Asp Leu Gly Asn Glu  Glu Gly Glu Glu Ile  Ser Tyr Ser 
    1460                 1465                 1470             


Gly Ile  Leu Asn Phe Asn Asn  Lys Ile Tyr Tyr Phe  Asp Asp Ser 
    1475                 1480                 1485             


Phe Thr  Ala Val Val Gly Trp  Lys Asp Leu Glu Asp  Gly Ser Lys 
    1490                 1495                 1500             


Tyr Tyr  Phe Asp Glu Asp Thr  Ala Glu Ala Tyr Ile  Gly Leu Ser 
    1505                 1510                 1515             


Leu Ile  Asn Asp Gly Gln Tyr  Tyr Phe Asn Asp Asp  Gly Ile Met 
    1520                 1525                 1530             


Gln Val  Gly Phe Val Thr Ile  Asn Asp Lys Val Phe  Tyr Phe Ser 
    1535                 1540                 1545             


Asp Ser  Gly Ile Ile Glu Ser  Gly Val Gln Asn Ile  Asp Asp Asn 
    1550                 1555                 1560             


Tyr Phe  Tyr Ile Asp Asp Asn  Gly Ile Val Gln Ile  Gly Val Phe 
    1565                 1570                 1575             


Asp Thr  Ser Asp Gly Tyr Lys  Tyr Phe Ala Pro Ala  Asn Thr Val 
    1580                 1585                 1590             


Asn Asp  Asn Ile Tyr Gly Gln  Ala Val Glu Tyr Ser  Gly Leu Val 
    1595                 1600                 1605             


Arg Val  Gly Glu Asp Val Tyr  Tyr Phe Gly Glu Thr  Tyr Thr Ile 
    1610                 1615                 1620             


Glu Thr  Gly Trp Ile Tyr Asp  Met Glu Asn Glu Ser  Asp Lys Tyr 
    1625                 1630                 1635             


Tyr Phe  Asn Pro Glu Thr Lys  Lys Ala Cys Lys Gly  Ile Asn Leu 
    1640                 1645                 1650             


Ile Asp  Asp Ile Lys Tyr Tyr  Phe Asp Glu Lys Gly  Ile Met Arg 
    1655                 1660                 1665             


Thr Gly  Leu Ile Ser Phe Glu  Asn Asn Asn Tyr Tyr  Phe Asn Glu 
    1670                 1675                 1680             


Asn Gly  Glu Met Gln Phe Gly  Tyr Ile Asn Ile Glu  Asp Lys Met 
    1685                 1690                 1695             


Phe Tyr  Phe Gly Glu Asp Gly  Val Met Gln Ile Gly  Val Phe Asn 
    1700                 1705                 1710             


Thr Pro  Asp Gly Phe Lys Tyr  Phe Ala His Gln Asn  Thr Leu Asp 
    1715                 1720                 1725             


Glu Asn  Phe Glu Gly Glu Ser  Ile Asn Tyr Thr Gly  Trp Leu Asp 
    1730                 1735                 1740             


Leu Asp  Glu Lys Arg Tyr Tyr  Phe Thr Asp Glu Tyr  Ile Ala Ala 
    1745                 1750                 1755             


Thr Gly  Ser Val Ile Ile Asp  Gly Glu Glu Tyr Tyr  Phe Asp Pro 
    1760                 1765                 1770             


Asp Thr  Ala Gln Leu Val Ile  Ser Glu 
    1775                 1780         


<210>  51
<211>  1769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  51

His His His His His His Ser His Met Ala Ser Asp Lys Ile Ile His 
1               5                   10                  15      


Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp Gly Ala 
            20                  25                  30          


Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys Met Ile 
        35                  40                  45              


Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys Leu Thr 
    50                  55                  60                  


Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro Lys Tyr 
65                  70                  75                  80  


Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly Glu Val 
                85                  90                  95      


Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys Glu Phe 
            100                 105                 110         


Leu Asp Ala Asn Leu Ala Arg Ala Leu Leu Ala Glu Ala Ala Ala Lys 
        115                 120                 125             


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
    130                 135                 140                 


Ala Ala Ala Lys Ala Ala Ala Gly Gly Ser Leu Val Pro Arg Gly Ser 
145                 150                 155                 160 


Gly Ser Ala Ala Ala Pro Phe Thr Met Ser Ile Ile Lys Asp Ile Ser 
                165                 170                 175     


Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn Lys Ile Thr Val 
            180                 185                 190         


Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu Gln Glu Ile Arg 
        195                 200                 205             


Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu Lys Val Met Leu 
    210                 215                 220                 


Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp Thr Gln Ile Val 
225                 230                 235                 240 


Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser Asp Ser Ile Asn 
                245                 250                 255     


Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile Ser Asp Ala Leu 
            260                 265                 270         


Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser His Phe Ile Ser 
        275                 280                 285             


Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser Ile Arg Phe Ile 
    290                 295                 300                 


Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr Glu Lys Thr Ile 
305                 310                 315                 320 


Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile Ser Lys Ile Lys 
                325                 330                 335     


Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val Lys Lys Val Asn 
            340                 345                 350         


Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala Ala Phe Phe Ile 
        355                 360                 365             


Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser Leu Ser Asn Leu 
    370                 375                 380                 


Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu Phe Ser Thr Gly 
385                 390                 395                 400 


Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu Leu Val Ser Thr 
                405                 410                 415     


Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr Leu Ser Glu Gly Leu 
            420                 425                 430         


Pro Ile Ile Ala Thr Ile Ile Asp Gly Val Ser Leu Gly Ala Ala Ile 
        435                 440                 445             


Lys Glu Leu Ser Glu Thr Ser Asp Pro Leu Leu Arg Gln Glu Ile Glu 
    450                 455                 460                 


Ala Lys Ile Gly Ile Met Ala Val Asn Leu Thr Thr Ala Thr Thr Ala 
465                 470                 475                 480 


Ile Ile Thr Ser Ser Leu Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu 
                485                 490                 495     


Val Pro Leu Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn 
            500                 505                 510         


Glu Leu Val Leu Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys 
        515                 520                 525             


His Val Ser Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp 
    530                 535                 540                 


Lys Ile Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe 
545                 550                 555                 560 


Asn Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu 
                565                 570                 575     


Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser 
            580                 585                 590         


Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp Val 
        595                 600                 605             


Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu Met Val 
    610                 615                 620                 


Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr Gly Trp Thr 
625                 630                 635                 640 


Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys Leu Leu Asp Arg 
                645                 650                 655     


Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp Arg Tyr Phe Ala Phe 
            660                 665                 670         


Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys Pro Arg Tyr Glu Asp Thr 
        675                 680                 685             


Asn Ile Arg Ile Asn Leu Asp Ser Asn Thr Arg Ser Phe Ile Val Pro 
    690                 695                 700                 


Ile Ile Thr Thr Glu Tyr Ile Arg Glu Lys Leu Ser Tyr Ser Phe Tyr 
705                 710                 715                 720 


Gly Ser Gly Gly Thr Tyr Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly 
                725                 730                 735     


Ile Asn Ile Glu Leu Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp 
            740                 745                 750         


Asn Val Val Arg Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly 
        755                 760                 765             


Asp Leu Ile Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys 
    770                 775                 780                 


Ile Ile Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly 
785                 790                 795                 800 


Ser Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn 
                805                 810                 815     


Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile 
            820                 825                 830         


Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln Gln 
        835                 840                 845             


Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn Ile Pro 
    850                 855                 860                 


Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe Ile Asn Gly 
865                 870                 875                 880 


Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro Asp Val Val Leu 
                885                 890                 895     


Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro Ser Phe Gly Tyr Tyr 
            900                 905                 910         


Ser Asn Asn Leu Lys Asp Val Lys Val Ile Thr Lys Asp Asn Val Asn 
        915                 920                 925             


Ile Leu Thr Gly Tyr Tyr Leu Lys Asp Asp Ile Lys Ile Ser Leu Ser 
    930                 935                 940                 


Leu Thr Leu Gln Asp Glu Lys Thr Ile Lys Leu Asn Ser Val His Leu 
945                 950                 955                 960 


Asp Glu Ser Gly Val Ala Glu Ile Leu Lys Phe Met Asn Arg Lys Gly 
                965                 970                 975     


Asn Thr Asn Thr Ser Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn 
            980                 985                 990         


Ile Lys Ser Ile Phe Val Asn Phe  Leu Gln Ser Asn Ile  Lys Phe Ile 
        995                 1000                 1005             


Leu Asp  Ala Asn Phe Ile Ile  Ser Gly Thr Thr Ser  Ile Gly Gln 
    1010                 1015                 1020             


Phe Glu  Phe Ile Cys Asp Glu  Asn Asp Asn Ile Gln  Pro Tyr Phe 
    1025                 1030                 1035             


Ile Lys  Phe Asn Thr Leu Glu  Thr Asn Tyr Thr Leu  Tyr Val Gly 
    1040                 1045                 1050             


Asn Arg  Gln Asn Met Ile Val  Glu Pro Asn Tyr Asp  Leu Asp Asp 
    1055                 1060                 1065             


Ser Gly  Asp Ile Ser Ser Thr  Val Ile Asn Phe Ser  Gln Lys Tyr 
    1070                 1075                 1080             


Leu Tyr  Gly Ile Asp Ser Cys  Val Asn Lys Val Val  Ile Ser Pro 
    1085                 1090                 1095             


Asn Ile  Tyr Thr Asp Glu Ile  Asn Ile Thr Pro Val  Tyr Glu Thr 
    1100                 1105                 1110             


Asn Asn  Thr Tyr Pro Glu Val  Ile Val Leu Asp Ala  Asn Tyr Ile 
    1115                 1120                 1125             


Asn Glu  Lys Ile Asn Val Asn  Ile Asn Asp Leu Ser  Ile Arg Tyr 
    1130                 1135                 1140             


Val Trp  Ser Asn Asp Gly Asn  Asp Phe Ile Leu Met  Ser Thr Ser 
    1145                 1150                 1155             


Glu Glu  Asn Lys Val Ser Gln  Val Lys Ile Arg Phe  Val Asn Val 
    1160                 1165                 1170             


Phe Lys  Asp Lys Thr Leu Ala  Asn Lys Leu Ser Phe  Asn Phe Ser 
    1175                 1180                 1185             


Asp Lys  Gln Asp Val Pro Val  Ser Glu Ile Ile Leu  Ser Phe Thr 
    1190                 1195                 1200             


Pro Ser  Tyr Tyr Glu Asp Gly  Leu Ile Gly Tyr Asp  Leu Gly Leu 
    1205                 1210                 1215             


Val Ser  Leu Tyr Asn Glu Lys  Phe Tyr Ile Asn Asn  Phe Gly Met 
    1220                 1225                 1230             


Met Val  Ser Gly Leu Ile Tyr  Ile Asn Asp Ser Leu  Tyr Tyr Phe 
    1235                 1240                 1245             


Lys Pro  Pro Val Asn Asn Leu  Ile Thr Gly Phe Val  Thr Val Gly 
    1250                 1255                 1260             


Asp Asp  Lys Tyr Tyr Phe Asn  Pro Ile Asn Gly Gly  Ala Ala Ser 
    1265                 1270                 1275             


Ile Gly  Glu Thr Ile Ile Asp  Asp Lys Asn Tyr Tyr  Phe Asn Gln 
    1280                 1285                 1290             


Ser Gly  Val Leu Gln Thr Gly  Val Phe Ser Thr Glu  Asp Gly Phe 
    1295                 1300                 1305             


Lys Tyr  Phe Ala Pro Ala Asn  Thr Leu Asp Glu Asn  Leu Glu Gly 
    1310                 1315                 1320             


Glu Ala  Ile Asp Phe Thr Gly  Lys Leu Ile Ile Asp  Glu Asn Ile 
    1325                 1330                 1335             


Tyr Tyr  Phe Asp Asp Asn Tyr  Arg Gly Ala Val Glu  Trp Lys Glu 
    1340                 1345                 1350             


Leu Asp  Gly Glu Met His Tyr  Phe Ser Pro Glu Thr  Gly Lys Ala 
    1355                 1360                 1365             


Phe Lys  Gly Leu Asn Gln Ile  Gly Asp Tyr Lys Tyr  Tyr Phe Asn 
    1370                 1375                 1380             


Ser Asp  Gly Val Met Gln Lys  Gly Phe Val Ser Ile  Asn Asp Asn 
    1385                 1390                 1395             


Lys His  Tyr Phe Asp Asp Ser  Gly Val Met Lys Val  Gly Tyr Thr 
    1400                 1405                 1410             


Glu Ile  Asp Gly Lys His Phe  Tyr Phe Ala Glu Asn  Gly Glu Met 
    1415                 1420                 1425             


Gln Ile  Gly Val Phe Asn Thr  Glu Asp Gly Phe Lys  Tyr Phe Ala 
    1430                 1435                 1440             


His His  Asn Glu Asp Leu Gly  Asn Glu Glu Gly Glu  Glu Ile Ser 
    1445                 1450                 1455             


Tyr Ser  Gly Ile Leu Asn Phe  Asn Asn Lys Ile Tyr  Tyr Phe Asp 
    1460                 1465                 1470             


Asp Ser  Phe Thr Ala Val Val  Gly Trp Lys Asp Leu  Glu Asp Gly 
    1475                 1480                 1485             


Ser Lys  Tyr Tyr Phe Asp Glu  Asp Thr Ala Glu Ala  Tyr Ile Gly 
    1490                 1495                 1500             


Leu Ser  Leu Ile Asn Asp Gly  Gln Tyr Tyr Phe Asn  Asp Asp Gly 
    1505                 1510                 1515             


Ile Met  Gln Val Gly Phe Val  Thr Ile Asn Asp Lys  Val Phe Tyr 
    1520                 1525                 1530             


Phe Ser  Asp Ser Gly Ile Ile  Glu Ser Gly Val Gln  Asn Ile Asp 
    1535                 1540                 1545             


Asp Asn  Tyr Phe Tyr Ile Asp  Asp Asn Gly Ile Val  Gln Ile Gly 
    1550                 1555                 1560             


Val Phe  Asp Thr Ser Asp Gly  Tyr Lys Tyr Phe Ala  Pro Ala Asn 
    1565                 1570                 1575             


Thr Val  Asn Asp Asn Ile Tyr  Gly Gln Ala Val Glu  Tyr Ser Gly 
    1580                 1585                 1590             


Leu Val  Arg Val Gly Glu Asp  Val Tyr Tyr Phe Gly  Glu Thr Tyr 
    1595                 1600                 1605             


Thr Ile  Glu Thr Gly Trp Ile  Tyr Asp Met Glu Asn  Glu Ser Asp 
    1610                 1615                 1620             


Lys Tyr  Tyr Phe Asn Pro Glu  Thr Lys Lys Ala Cys  Lys Gly Ile 
    1625                 1630                 1635             


Asn Leu  Ile Asp Asp Ile Lys  Tyr Tyr Phe Asp Glu  Lys Gly Ile 
    1640                 1645                 1650             


Met Arg  Thr Gly Leu Ile Ser  Phe Glu Asn Asn Asn  Tyr Tyr Phe 
    1655                 1660                 1665             


Asn Glu  Asn Gly Glu Met Gln  Phe Gly Tyr Ile Asn  Ile Glu Asp 
    1670                 1675                 1680             


Lys Met  Phe Tyr Phe Gly Glu  Asp Gly Val Met Gln  Ile Gly Val 
    1685                 1690                 1695             


Phe Asn  Thr Pro Asp Gly Phe  Lys Tyr Phe Ala His  Gln Asn Thr 
    1700                 1705                 1710             


Leu Asp  Glu Asn Phe Glu Gly  Glu Ser Ile Asn Tyr  Thr Gly Trp 
    1715                 1720                 1725             


Leu Asp  Leu Asp Glu Lys Arg  Tyr Tyr Phe Thr Asp  Glu Tyr Ile 
    1730                 1735                 1740             


Ala Ala  Thr Gly Ser Val Ile  Ile Asp Gly Glu Glu  Tyr Tyr Phe 
    1745                 1750                 1755             


Asp Pro  Asp Thr Ala Gln Leu  Val Ile Ser Glu 
    1760                 1765                 


<210>  52
<211>  1402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  52

His His His His His His His His His His Gly Gly Ser Leu Ala Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Ala Gly Gly Ser His Met 
        35                  40                  45              


Ala Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
    50                  55                  60                  


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
65                  70                  75                  80  


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
                85                  90                  95      


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
            100                 105                 110         


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
        115                 120                 125             


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
    130                 135                 140                 


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Arg Ala Leu 
145                 150                 155                 160 


Val Pro Arg Gly Ser Val Thr Ser Leu Tyr Lys Lys Ala Gly Ser Ala 
                165                 170                 175     


Ala Gly Gly Ser Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp 
            180                 185                 190         


Phe Asn Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met 
        195                 200                 205             


Glu Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe 
    210                 215                 220                 


Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp 
225                 230                 235                 240 


Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu Met 
                245                 250                 255     


Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr Gly Trp 
            260                 265                 270         


Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys Leu Leu Asp 
        275                 280                 285             


Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp Arg Tyr Phe Ala 
    290                 295                 300                 


Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys Pro Arg Tyr Glu Asp 
305                 310                 315                 320 


Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn Thr Arg Ser Phe Ile Val 
                325                 330                 335     


Pro Ile Ile Thr Thr Glu Tyr Ile Arg Glu Lys Leu Ser Tyr Ser Phe 
            340                 345                 350         


Tyr Gly Ser Gly Gly Thr Tyr Ala Leu Ser Leu Ser Gln Tyr Asn Met 
        355                 360                 365             


Gly Ile Asn Ile Glu Leu Ser Glu Ser Asp Val Trp Ile Ile Asp Val 
    370                 375                 380                 


Asp Asn Val Val Arg Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys 
385                 390                 395                 400 


Gly Asp Leu Ile Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn 
                405                 410                 415     


Lys Ile Ile Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn 
            420                 425                 430         


Gly Ser Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile 
        435                 440                 445             


Asn Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu 
    450                 455                 460                 


Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln 
465                 470                 475                 480 


Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn Ile 
                485                 490                 495     


Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe Ile Asn 
            500                 505                 510         


Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro Asp Val Val 
        515                 520                 525             


Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro Ser Phe Gly Tyr 
    530                 535                 540                 


Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile Thr Lys Asp Asn Val 
545                 550                 555                 560 


Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp Asp Ile Lys Ile Ser Leu 
                565                 570                 575     


Ser Leu Thr Leu Gln Asp Glu Lys Thr Ile Lys Leu Asn Ser Val His 
            580                 585                 590         


Leu Asp Glu Ser Gly Val Ala Glu Ile Leu Lys Phe Met Asn Arg Lys 
        595                 600                 605             


Gly Asn Thr Asn Thr Ser Asp Ser Leu Met Ser Phe Leu Glu Ser Met 
    610                 615                 620                 


Asn Ile Lys Ser Ile Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe 
625                 630                 635                 640 


Ile Leu Asp Ala Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln 
                645                 650                 655     


Phe Glu Phe Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile 
            660                 665                 670         


Lys Phe Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg 
        675                 680                 685             


Gln Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp 
    690                 695                 700                 


Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile 
705                 710                 715                 720 


Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr Asp 
                725                 730                 735     


Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr Pro Glu 
            740                 745                 750         


Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile Asn Val Asn 
        755                 760                 765             


Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn Asp Gly Asn Asp 
    770                 775                 780                 


Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys 
785                 790                 795                 800 


Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu 
                805                 810                 815     


Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile 
            820                 825                 830         


Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp 
        835                 840                 845             


Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe 
    850                 855                 860                 


Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr 
865                 870                 875                 880 


Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly 
                885                 890                 895     


Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile 
            900                 905                 910         


Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly 
        915                 920                 925             


Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe 
    930                 935                 940                 


Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp 
945                 950                 955                 960 


Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp 
                965                 970                 975     


Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His 
            980                 985                 990         


Tyr Phe Ser Pro Glu Thr Gly Lys  Ala Phe Lys Gly Leu  Asn Gln Ile 
        995                 1000                 1005             


Gly Asp  Tyr Lys Tyr Tyr Phe  Asn Ser Asp Gly Val  Met Gln Lys 
    1010                 1015                 1020             


Gly Phe  Val Ser Ile Asn Asp  Asn Lys His Tyr Phe  Asp Asp Ser 
    1025                 1030                 1035             


Gly Val  Met Lys Val Gly Tyr  Thr Glu Ile Asp Gly  Lys His Phe 
    1040                 1045                 1050             


Tyr Phe  Ala Glu Asn Gly Glu  Met Gln Ile Gly Val  Phe Asn Thr 
    1055                 1060                 1065             


Glu Asp  Gly Phe Lys Tyr Phe  Ala His His Asn Glu  Asp Leu Gly 
    1070                 1075                 1080             


Asn Glu  Glu Gly Glu Glu Ile  Ser Tyr Ser Gly Ile  Leu Asn Phe 
    1085                 1090                 1095             


Asn Asn  Lys Ile Tyr Tyr Phe  Asp Asp Ser Phe Thr  Ala Val Val 
    1100                 1105                 1110             


Gly Trp  Lys Asp Leu Glu Asp  Gly Ser Lys Tyr Tyr  Phe Asp Glu 
    1115                 1120                 1125             


Asp Thr  Ala Glu Ala Tyr Ile  Gly Leu Ser Leu Ile  Asn Asp Gly 
    1130                 1135                 1140             


Gln Tyr  Tyr Phe Asn Asp Asp  Gly Ile Met Gln Val  Gly Phe Val 
    1145                 1150                 1155             


Thr Ile  Asn Asp Lys Val Phe  Tyr Phe Ser Asp Ser  Gly Ile Ile 
    1160                 1165                 1170             


Glu Ser  Gly Val Gln Asn Ile  Asp Asp Asn Tyr Phe  Tyr Ile Asp 
    1175                 1180                 1185             


Asp Asn  Gly Ile Val Gln Ile  Gly Val Phe Asp Thr  Ser Asp Gly 
    1190                 1195                 1200             


Tyr Lys  Tyr Phe Ala Pro Ala  Asn Thr Val Asn Asp  Asn Ile Tyr 
    1205                 1210                 1215             


Gly Gln  Ala Val Glu Tyr Ser  Gly Leu Val Arg Val  Gly Glu Asp 
    1220                 1225                 1230             


Val Tyr  Tyr Phe Gly Glu Thr  Tyr Thr Ile Glu Thr  Gly Trp Ile 
    1235                 1240                 1245             


Tyr Asp  Met Glu Asn Glu Ser  Asp Lys Tyr Tyr Phe  Asn Pro Glu 
    1250                 1255                 1260             


Thr Lys  Lys Ala Cys Lys Gly  Ile Asn Leu Ile Asp  Asp Ile Lys 
    1265                 1270                 1275             


Tyr Tyr  Phe Asp Glu Lys Gly  Ile Met Arg Thr Gly  Leu Ile Ser 
    1280                 1285                 1290             


Phe Glu  Asn Asn Asn Tyr Tyr  Phe Asn Glu Asn Gly  Glu Met Gln 
    1295                 1300                 1305             


Phe Gly  Tyr Ile Asn Ile Glu  Asp Lys Met Phe Tyr  Phe Gly Glu 
    1310                 1315                 1320             


Asp Gly  Val Met Gln Ile Gly  Val Phe Asn Thr Pro  Asp Gly Phe 
    1325                 1330                 1335             


Lys Tyr  Phe Ala His Gln Asn  Thr Leu Asp Glu Asn  Phe Glu Gly 
    1340                 1345                 1350             


Glu Ser  Ile Asn Tyr Thr Gly  Trp Leu Asp Leu Asp  Glu Lys Arg 
    1355                 1360                 1365             


Tyr Tyr  Phe Thr Asp Glu Tyr  Ile Ala Ala Thr Gly  Ser Val Ile 
    1370                 1375                 1380             


Ile Asp  Gly Glu Glu Tyr Tyr  Phe Asp Pro Asp Thr  Ala Gln Leu 
    1385                 1390                 1395             


Val Ile  Ser Glu 
    1400         


<210>  53
<211>  1389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  53

His His His His His His Ser His Met Ala Ser Asp Lys Ile Ile His 
1               5                   10                  15      


Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp Gly Ala 
            20                  25                  30          


Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys Met Ile 
        35                  40                  45              


Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys Leu Thr 
    50                  55                  60                  


Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro Lys Tyr 
65                  70                  75                  80  


Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly Glu Val 
                85                  90                  95      


Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys Glu Phe 
            100                 105                 110         


Leu Asp Ala Asn Leu Ala Arg Ala Leu Leu Ala Glu Ala Ala Ala Lys 
        115                 120                 125             


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
    130                 135                 140                 


Ala Ala Ala Lys Ala Ala Ala Gly Gly Ser Leu Val Pro Arg Gly Ser 
145                 150                 155                 160 


Gly Ser Ala Ala Gly Gly Ser Met Pro Gln Asp Asp Leu Val Ile Ser 
                165                 170                 175     


Glu Ile Asp Phe Asn Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile 
            180                 185                 190         


Trp Arg Met Glu Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp 
        195                 200                 205             


His Phe Phe Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser 
    210                 215                 220                 


Ile Tyr Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys 
225                 230                 235                 240 


Asp Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu 
                245                 250                 255     


Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys 
            260                 265                 270         


Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp Arg 
        275                 280                 285             


Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys Pro Arg 
    290                 295                 300                 


Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn Thr Arg Ser 
305                 310                 315                 320 


Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg Glu Lys Leu Ser 
                325                 330                 335     


Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala Leu Ser Leu Ser Gln 
            340                 345                 350         


Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser Glu Ser Asp Val Trp Ile 
        355                 360                 365             


Ile Asp Val Asp Asn Val Val Arg Asp Val Thr Ile Glu Ser Asp Lys 
    370                 375                 380                 


Ile Lys Lys Gly Asp Leu Ile Glu Gly Ile Leu Ser Thr Leu Ser Ile 
385                 390                 395                 400 


Glu Glu Asn Lys Ile Ile Leu Asn Ser His Glu Ile Asn Phe Ser Gly 
                405                 410                 415     


Glu Val Asn Gly Ser Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu 
            420                 425                 430         


Glu Gly Ile Asn Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr 
        435                 440                 445             


Lys Leu Leu Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn 
    450                 455                 460                 


His Ile Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln 
465                 470                 475                 480 


Lys Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly 
                485                 490                 495     


Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro 
            500                 505                 510         


Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro Ser 
        515                 520                 525             


Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile Thr Lys 
    530                 535                 540                 


Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp Asp Ile Lys 
545                 550                 555                 560 


Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr Ile Lys Leu Asn 
                565                 570                 575     


Ser Val His Leu Asp Glu Ser Gly Val Ala Glu Ile Leu Lys Phe Met 
            580                 585                 590         


Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp Ser Leu Met Ser Phe Leu 
        595                 600                 605             


Glu Ser Met Asn Ile Lys Ser Ile Phe Val Asn Phe Leu Gln Ser Asn 
    610                 615                 620                 


Ile Lys Phe Ile Leu Asp Ala Asn Phe Ile Ile Ser Gly Thr Thr Ser 
625                 630                 635                 640 


Ile Gly Gln Phe Glu Phe Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro 
                645                 650                 655     


Tyr Phe Ile Lys Phe Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val 
            660                 665                 670         


Gly Asn Arg Gln Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp 
        675                 680                 685             


Ser Gly Asp Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu 
    690                 695                 700                 


Tyr Gly Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile 
705                 710                 715                 720 


Tyr Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr 
                725                 730                 735     


Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile 
            740                 745                 750         


Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn Asp 
        755                 760                 765             


Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser 
    770                 775                 780                 


Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala 
785                 790                 795                 800 


Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser 
                805                 810                 815     


Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile 
            820                 825                 830         


Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile 
        835                 840                 845             


Asn Asn Phe Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser 
    850                 855                 860                 


Leu Tyr Tyr Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val 
865                 870                 875                 880 


Thr Val Gly Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala 
                885                 890                 895     


Ala Ser Ile Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn 
            900                 905                 910         


Gln Ser Gly Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe 
        915                 920                 925             


Lys Tyr Phe Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu 
    930                 935                 940                 


Ala Ile Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr 
945                 950                 955                 960 


Phe Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly 
                965                 970                 975     


Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu 
            980                 985                 990         


Asn Gln Ile Gly Asp Tyr Lys Tyr  Tyr Phe Asn Ser Asp  Gly Val Met 
        995                 1000                 1005             


Gln Lys  Gly Phe Val Ser Ile  Asn Asp Asn Lys His  Tyr Phe Asp 
    1010                 1015                 1020             


Asp Ser  Gly Val Met Lys Val  Gly Tyr Thr Glu Ile  Asp Gly Lys 
    1025                 1030                 1035             


His Phe  Tyr Phe Ala Glu Asn  Gly Glu Met Gln Ile  Gly Val Phe 
    1040                 1045                 1050             


Asn Thr  Glu Asp Gly Phe Lys  Tyr Phe Ala His His  Asn Glu Asp 
    1055                 1060                 1065             


Leu Gly  Asn Glu Glu Gly Glu  Glu Ile Ser Tyr Ser  Gly Ile Leu 
    1070                 1075                 1080             


Asn Phe  Asn Asn Lys Ile Tyr  Tyr Phe Asp Asp Ser  Phe Thr Ala 
    1085                 1090                 1095             


Val Val  Gly Trp Lys Asp Leu  Glu Asp Gly Ser Lys  Tyr Tyr Phe 
    1100                 1105                 1110             


Asp Glu  Asp Thr Ala Glu Ala  Tyr Ile Gly Leu Ser  Leu Ile Asn 
    1115                 1120                 1125             


Asp Gly  Gln Tyr Tyr Phe Asn  Asp Asp Gly Ile Met  Gln Val Gly 
    1130                 1135                 1140             


Phe Val  Thr Ile Asn Asp Lys  Val Phe Tyr Phe Ser  Asp Ser Gly 
    1145                 1150                 1155             


Ile Ile  Glu Ser Gly Val Gln  Asn Ile Asp Asp Asn  Tyr Phe Tyr 
    1160                 1165                 1170             


Ile Asp  Asp Asn Gly Ile Val  Gln Ile Gly Val Phe  Asp Thr Ser 
    1175                 1180                 1185             


Asp Gly  Tyr Lys Tyr Phe Ala  Pro Ala Asn Thr Val  Asn Asp Asn 
    1190                 1195                 1200             


Ile Tyr  Gly Gln Ala Val Glu  Tyr Ser Gly Leu Val  Arg Val Gly 
    1205                 1210                 1215             


Glu Asp  Val Tyr Tyr Phe Gly  Glu Thr Tyr Thr Ile  Glu Thr Gly 
    1220                 1225                 1230             


Trp Ile  Tyr Asp Met Glu Asn  Glu Ser Asp Lys Tyr  Tyr Phe Asn 
    1235                 1240                 1245             


Pro Glu  Thr Lys Lys Ala Cys  Lys Gly Ile Asn Leu  Ile Asp Asp 
    1250                 1255                 1260             


Ile Lys  Tyr Tyr Phe Asp Glu  Lys Gly Ile Met Arg  Thr Gly Leu 
    1265                 1270                 1275             


Ile Ser  Phe Glu Asn Asn Asn  Tyr Tyr Phe Asn Glu  Asn Gly Glu 
    1280                 1285                 1290             


Met Gln  Phe Gly Tyr Ile Asn  Ile Glu Asp Lys Met  Phe Tyr Phe 
    1295                 1300                 1305             


Gly Glu  Asp Gly Val Met Gln  Ile Gly Val Phe Asn  Thr Pro Asp 
    1310                 1315                 1320             


Gly Phe  Lys Tyr Phe Ala His  Gln Asn Thr Leu Asp  Glu Asn Phe 
    1325                 1330                 1335             


Glu Gly  Glu Ser Ile Asn Tyr  Thr Gly Trp Leu Asp  Leu Asp Glu 
    1340                 1345                 1350             


Lys Arg  Tyr Tyr Phe Thr Asp  Glu Tyr Ile Ala Ala  Thr Gly Ser 
    1355                 1360                 1365             


Val Ile  Ile Asp Gly Glu Glu  Tyr Tyr Phe Asp Pro  Asp Thr Ala 
    1370                 1375                 1380             


Gln Leu  Val Ile Ser Glu 
    1385                 


<210>  54
<211>  1395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  54

His His His His His His His His His Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Ser His Met Ala Ser Asp Lys Ile Ile His 
        35                  40                  45              


Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp Gly Ala 
    50                  55                  60                  


Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys Met Ile 
65                  70                  75                  80  


Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys Leu Thr 
                85                  90                  95      


Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro Lys Tyr 
            100                 105                 110         


Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly Glu Val 
        115                 120                 125             


Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys Glu Phe 
    130                 135                 140                 


Leu Asp Ala Asn Leu Ala Arg Ala Leu Val Pro Arg Gly Ser Val Thr 
145                 150                 155                 160 


Ser Leu Tyr Lys Lys Ala Gly Ser Ala Ala Gly Gly Ser Met Pro Gln 
                165                 170                 175     


Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Val 
            180                 185                 190         


Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly Gly Ser Gly His Thr 
        195                 200                 205             


Val Thr Asp Asp Ile Asp His Phe Phe Ser Ala Pro Ser Ile Thr Tyr 
    210                 215                 220                 


Arg Glu Pro His Leu Ser Ile Tyr Asp Val Leu Glu Val Gln Lys Glu 
225                 230                 235                 240 


Glu Leu Asp Leu Ser Lys Asp Leu Met Val Leu Pro Asn Ala Pro Asn 
                245                 250                 255     


Arg Val Phe Ala Trp Glu Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu 
            260                 265                 270         


Glu Asn Asp Gly Thr Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu 
        275                 280                 285             


Gly Glu Phe Tyr Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile 
    290                 295                 300                 


Thr Thr Leu Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu 
305                 310                 315                 320 


Asp Ser Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr 
                325                 330                 335     


Ile Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr 
            340                 345                 350         


Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser 
        355                 360                 365             


Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp Val 
    370                 375                 380                 


Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu Gly Ile 
385                 390                 395                 400 


Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu Asn Ser His 
                405                 410                 415     


Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn Gly Phe Val Ser 
            420                 425                 430         


Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala Ile Ile Glu Val Asp 
        435                 440                 445             


Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile Ser Gly Glu Leu Lys Ile 
    450                 455                 460                 


Leu Met Leu Asn Ser Asn His Ile Gln Gln Lys Ile Asp Tyr Ile Gly 
465                 470                 475                 480 


Phe Asn Ser Glu Leu Gln Lys Asn Ile Pro Tyr Ser Phe Val Asp Ser 
                485                 490                 495     


Glu Gly Lys Glu Asn Gly Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu 
            500                 505                 510         


Phe Val Ser Glu Leu Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met 
        515                 520                 525             


Asp Asp Ser Lys Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp 
    530                 535                 540                 


Val Lys Val Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr 
545                 550                 555                 560 


Leu Lys Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu 
                565                 570                 575     


Lys Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala 
            580                 585                 590         


Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp 
        595                 600                 605             


Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe Val 
    610                 615                 620                 


Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn Phe Ile 
625                 630                 635                 640 


Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile Cys Asp Glu 
                645                 650                 655     


Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn Thr Leu Glu Thr 
            660                 665                 670         


Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn Met Ile Val Glu Pro 
        675                 680                 685             


Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile Ser Ser Thr Val Ile Asn 
    690                 695                 700                 


Phe Ser Gln Lys Tyr Leu Tyr Gly Ile Asp Ser Cys Val Asn Lys Val 
705                 710                 715                 720 


Val Ile Ser Pro Asn Ile Tyr Thr Asp Glu Ile Asn Ile Thr Pro Val 
                725                 730                 735     


Tyr Glu Thr Asn Asn Thr Tyr Pro Glu Val Ile Val Leu Asp Ala Asn 
            740                 745                 750         


Tyr Ile Asn Glu Lys Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg 
        755                 760                 765             


Tyr Val Trp Ser Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser 
    770                 775                 780                 


Glu Glu Asn Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe 
785                 790                 795                 800 


Lys Asp Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys 
                805                 810                 815     


Gln Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr 
            820                 825                 830         


Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr 
        835                 840                 845             


Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly Leu 
    850                 855                 860                 


Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val Asn Asn 
865                 870                 875                 880 


Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr Tyr Phe Asn 
                885                 890                 895     


Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr Ile Ile Asp Asp 
            900                 905                 910         


Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu Gln Thr Gly Val Phe 
        915                 920                 925             


Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asn Thr Leu Asp 
    930                 935                 940                 


Glu Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys Leu Ile Ile 
945                 950                 955                 960 


Asp Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr Arg Gly Ala Val Glu 
                965                 970                 975     


Trp Lys Glu Leu Asp Gly Glu Met His Tyr Phe Ser Pro Glu Thr Gly 
            980                 985                 990         


Lys Ala Phe Lys Gly Leu Asn Gln  Ile Gly Asp Tyr Lys  Tyr Tyr Phe 
        995                 1000                 1005             


Asn Ser  Asp Gly Val Met Gln  Lys Gly Phe Val Ser  Ile Asn Asp 
    1010                 1015                 1020             


Asn Lys  His Tyr Phe Asp Asp  Ser Gly Val Met Lys  Val Gly Tyr 
    1025                 1030                 1035             


Thr Glu  Ile Asp Gly Lys His  Phe Tyr Phe Ala Glu  Asn Gly Glu 
    1040                 1045                 1050             


Met Gln  Ile Gly Val Phe Asn  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1055                 1060                 1065             


Ala His  His Asn Glu Asp Leu  Gly Asn Glu Glu Gly  Glu Glu Ile 
    1070                 1075                 1080             


Ser Tyr  Ser Gly Ile Leu Asn  Phe Asn Asn Lys Ile  Tyr Tyr Phe 
    1085                 1090                 1095             


Asp Asp  Ser Phe Thr Ala Val  Val Gly Trp Lys Asp  Leu Glu Asp 
    1100                 1105                 1110             


Gly Ser  Lys Tyr Tyr Phe Asp  Glu Asp Thr Ala Glu  Ala Tyr Ile 
    1115                 1120                 1125             


Gly Leu  Ser Leu Ile Asn Asp  Gly Gln Tyr Tyr Phe  Asn Asp Asp 
    1130                 1135                 1140             


Gly Ile  Met Gln Val Gly Phe  Val Thr Ile Asn Asp  Lys Val Phe 
    1145                 1150                 1155             


Tyr Phe  Ser Asp Ser Gly Ile  Ile Glu Ser Gly Val  Gln Asn Ile 
    1160                 1165                 1170             


Asp Asp  Asn Tyr Phe Tyr Ile  Asp Asp Asn Gly Ile  Val Gln Ile 
    1175                 1180                 1185             


Gly Val  Phe Asp Thr Ser Asp  Gly Tyr Lys Tyr Phe  Ala Pro Ala 
    1190                 1195                 1200             


Asn Thr  Val Asn Asp Asn Ile  Tyr Gly Gln Ala Val  Glu Tyr Ser 
    1205                 1210                 1215             


Gly Leu  Val Arg Val Gly Glu  Asp Val Tyr Tyr Phe  Gly Glu Thr 
    1220                 1225                 1230             


Tyr Thr  Ile Glu Thr Gly Trp  Ile Tyr Asp Met Glu  Asn Glu Ser 
    1235                 1240                 1245             


Asp Lys  Tyr Tyr Phe Asn Pro  Glu Thr Lys Lys Ala  Cys Lys Gly 
    1250                 1255                 1260             


Ile Asn  Leu Ile Asp Asp Ile  Lys Tyr Tyr Phe Asp  Glu Lys Gly 
    1265                 1270                 1275             


Ile Met  Arg Thr Gly Leu Ile  Ser Phe Glu Asn Asn  Asn Tyr Tyr 
    1280                 1285                 1290             


Phe Asn  Glu Asn Gly Glu Met  Gln Phe Gly Tyr Ile  Asn Ile Glu 
    1295                 1300                 1305             


Asp Lys  Met Phe Tyr Phe Gly  Glu Asp Gly Val Met  Gln Ile Gly 
    1310                 1315                 1320             


Val Phe  Asn Thr Pro Asp Gly  Phe Lys Tyr Phe Ala  His Gln Asn 
    1325                 1330                 1335             


Thr Leu  Asp Glu Asn Phe Glu  Gly Glu Ser Ile Asn  Tyr Thr Gly 
    1340                 1345                 1350             


Trp Leu  Asp Leu Asp Glu Lys  Arg Tyr Tyr Phe Thr  Asp Glu Tyr 
    1355                 1360                 1365             


Ile Ala  Ala Thr Gly Ser Val  Ile Ile Asp Gly Glu  Glu Tyr Tyr 
    1370                 1375                 1380             


Phe Asp  Pro Asp Thr Ala Gln  Leu Val Ile Ser Glu  
    1385                 1390                 1395 


<210>  55
<211>  1383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  55

His His His His His His Ser His Met Ala Ser Asp Lys Ile Ile His 
1               5                   10                  15      


Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp Gly Ala 
            20                  25                  30          


Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys Met Ile 
        35                  40                  45              


Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys Leu Thr 
    50                  55                  60                  


Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro Lys Tyr 
65                  70                  75                  80  


Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly Glu Val 
                85                  90                  95      


Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys Glu Phe 
            100                 105                 110         


Leu Asp Ala Asn Leu Ala Arg Ala Leu Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Ser Ala Ala Gly Gly 
145                 150                 155                 160 


Ser Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn 
                165                 170                 175     


Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly Gly 
            180                 185                 190         


Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser Ala Pro 
        195                 200                 205             


Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp Val Leu Glu 
    210                 215                 220                 


Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu Met Val Leu Pro 
225                 230                 235                 240 


Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr Gly Trp Thr Pro Gly 
                245                 250                 255     


Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys Leu Leu Asp Arg Ile Arg 
            260                 265                 270         


Asp Asn Tyr Glu Gly Glu Phe Tyr Trp Arg Tyr Phe Ala Phe Ile Ala 
        275                 280                 285             


Asp Ala Leu Ile Thr Thr Leu Lys Pro Arg Tyr Glu Asp Thr Asn Ile 
    290                 295                 300                 


Arg Ile Asn Leu Asp Ser Asn Thr Arg Ser Phe Ile Val Pro Ile Ile 
305                 310                 315                 320 


Thr Thr Glu Tyr Ile Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser 
                325                 330                 335     


Gly Gly Thr Tyr Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn 
            340                 345                 350         


Ile Glu Leu Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val 
        355                 360                 365             


Val Arg Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu 
    370                 375                 380                 


Ile Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile 
385                 390                 395                 400 


Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn 
                405                 410                 415     


Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala Ile 
            420                 425                 430         


Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile Ser Gly 
        435                 440                 445             


Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln Gln Lys Ile 
    450                 455                 460                 


Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn Ile Pro Tyr Ser 
465                 470                 475                 480 


Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe Ile Asn Gly Ser Thr 
                485                 490                 495     


Lys Glu Gly Leu Phe Val Ser Glu Leu Pro Asp Val Val Leu Ile Ser 
            500                 505                 510         


Lys Val Tyr Met Asp Asp Ser Lys Pro Ser Phe Gly Tyr Tyr Ser Asn 
        515                 520                 525             


Asn Leu Lys Asp Val Lys Val Ile Thr Lys Asp Asn Val Asn Ile Leu 
    530                 535                 540                 


Thr Gly Tyr Tyr Leu Lys Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr 
545                 550                 555                 560 


Leu Gln Asp Glu Lys Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu 
                565                 570                 575     


Ser Gly Val Ala Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr 
            580                 585                 590         


Asn Thr Ser Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys 
        595                 600                 605             


Ser Ile Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp 
    610                 615                 620                 


Ala Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe 
625                 630                 635                 640 


Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn 
                645                 650                 655     


Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn Met 
            660                 665                 670         


Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile Ser Ser 
        675                 680                 685             


Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile Asp Ser Cys 
    690                 695                 700                 


Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr Asp Glu Ile Asn 
705                 710                 715                 720 


Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr Pro Glu Val Ile Val 
                725                 730                 735     


Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile Asn Val Asn Ile Asn Asp 
            740                 745                 750         


Leu Ser Ile Arg Tyr Val Trp Ser Asn Asp Gly Asn Asp Phe Ile Leu 
        755                 760                 765             


Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys Ile Arg Phe 
    770                 775                 780                 


Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn 
785                 790                 795                 800 


Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe 
                805                 810                 815     


Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu 
            820                 825                 830         


Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met 
        835                 840                 845             


Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro 
    850                 855                 860                 


Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys 
865                 870                 875                 880 


Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr 
                885                 890                 895     


Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu Gln 
            900                 905                 910         


Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala 
        915                 920                 925             


Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly 
    930                 935                 940                 


Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr Arg 
945                 950                 955                 960 


Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His Tyr Phe Ser 
                965                 970                 975     


Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp Tyr 
            980                 985                 990         


Lys Tyr Tyr Phe Asn Ser Asp Gly  Val Met Gln Lys Gly  Phe Val Ser 
        995                 1000                 1005             


Ile Asn  Asp Asn Lys His Tyr  Phe Asp Asp Ser Gly  Val Met Lys 
    1010                 1015                 1020             


Val Gly  Tyr Thr Glu Ile Asp  Gly Lys His Phe Tyr  Phe Ala Glu 
    1025                 1030                 1035             


Asn Gly  Glu Met Gln Ile Gly  Val Phe Asn Thr Glu  Asp Gly Phe 
    1040                 1045                 1050             


Lys Tyr  Phe Ala His His Asn  Glu Asp Leu Gly Asn  Glu Glu Gly 
    1055                 1060                 1065             


Glu Glu  Ile Ser Tyr Ser Gly  Ile Leu Asn Phe Asn  Asn Lys Ile 
    1070                 1075                 1080             


Tyr Tyr  Phe Asp Asp Ser Phe  Thr Ala Val Val Gly  Trp Lys Asp 
    1085                 1090                 1095             


Leu Glu  Asp Gly Ser Lys Tyr  Tyr Phe Asp Glu Asp  Thr Ala Glu 
    1100                 1105                 1110             


Ala Tyr  Ile Gly Leu Ser Leu  Ile Asn Asp Gly Gln  Tyr Tyr Phe 
    1115                 1120                 1125             


Asn Asp  Asp Gly Ile Met Gln  Val Gly Phe Val Thr  Ile Asn Asp 
    1130                 1135                 1140             


Lys Val  Phe Tyr Phe Ser Asp  Ser Gly Ile Ile Glu  Ser Gly Val 
    1145                 1150                 1155             


Gln Asn  Ile Asp Asp Asn Tyr  Phe Tyr Ile Asp Asp  Asn Gly Ile 
    1160                 1165                 1170             


Val Gln  Ile Gly Val Phe Asp  Thr Ser Asp Gly Tyr  Lys Tyr Phe 
    1175                 1180                 1185             


Ala Pro  Ala Asn Thr Val Asn  Asp Asn Ile Tyr Gly  Gln Ala Val 
    1190                 1195                 1200             


Glu Tyr  Ser Gly Leu Val Arg  Val Gly Glu Asp Val  Tyr Tyr Phe 
    1205                 1210                 1215             


Gly Glu  Thr Tyr Thr Ile Glu  Thr Gly Trp Ile Tyr  Asp Met Glu 
    1220                 1225                 1230             


Asn Glu  Ser Asp Lys Tyr Tyr  Phe Asn Pro Glu Thr  Lys Lys Ala 
    1235                 1240                 1245             


Cys Lys  Gly Ile Asn Leu Ile  Asp Asp Ile Lys Tyr  Tyr Phe Asp 
    1250                 1255                 1260             


Glu Lys  Gly Ile Met Arg Thr  Gly Leu Ile Ser Phe  Glu Asn Asn 
    1265                 1270                 1275             


Asn Tyr  Tyr Phe Asn Glu Asn  Gly Glu Met Gln Phe  Gly Tyr Ile 
    1280                 1285                 1290             


Asn Ile  Glu Asp Lys Met Phe  Tyr Phe Gly Glu Asp  Gly Val Met 
    1295                 1300                 1305             


Gln Ile  Gly Val Phe Asn Thr  Pro Asp Gly Phe Lys  Tyr Phe Ala 
    1310                 1315                 1320             


His Gln  Asn Thr Leu Asp Glu  Asn Phe Glu Gly Glu  Ser Ile Asn 
    1325                 1330                 1335             


Tyr Thr  Gly Trp Leu Asp Leu  Asp Glu Lys Arg Tyr  Tyr Phe Thr 
    1340                 1345                 1350             


Asp Glu  Tyr Ile Ala Ala Thr  Gly Ser Val Ile Ile  Asp Gly Glu 
    1355                 1360                 1365             


Glu Tyr  Tyr Phe Asp Pro Asp  Thr Ala Gln Leu Val  Ile Ser Glu 
    1370                 1375                 1380             


<210>  56
<211>  2317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  56

Met Gly Ser Ser His His His His His His Ser His Met Ala Ser Asn 
1               5                   10                  15      


Lys Glu Ile Leu Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu 
            20                  25                  30          


Pro Arg Glu Lys Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala 
        35                  40                  45              


Thr Lys Lys Lys Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp 
    50                  55                  60                  


Arg Lys Ser Gly Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp 
65                  70                  75                  80  


Glu Val Thr Gln Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr 
                85                  90                  95      


Glu Asp Glu Ser Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu 
            100                 105                 110         


Ser Val Thr Phe Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile 
        115                 120                 125             


Val Gln Lys Val Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe 
    130                 135                 140                 


Arg Glu His Glu Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn 
145                 150                 155                 160 


Arg Asp Asn Ile Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile 
                165                 170                 175     


Leu Arg Glu Asp Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg 
            180                 185                 190         


Val Arg Gly Val Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln 
        195                 200                 205             


Leu Phe Val Thr Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg 
    210                 215                 220                 


Ile Glu Val Pro Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala 
225                 230                 235                 240 


Ala Arg Asp Pro Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp 
                245                 250                 255     


Lys Arg Ile Asp Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg 
            260                 265                 270         


Val Gln Ala Val Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val 
        275                 280                 285             


Leu Trp Asp Asp Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro 
    290                 295                 300                 


Ala Asp Val Ala Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp 
305                 310                 315                 320 


Ile Ala Val Glu Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly 
                325                 330                 335     


Gln Asn Val Arg Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val 
            340                 345                 350         


Met Thr Val Asp Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala 
        355                 360                 365             


Ala Ile Asp Thr Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala 
    370                 375                 380                 


Thr Val Leu Val Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr 
385                 390                 395                 400 


Val Pro Met Lys Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr 
                405                 410                 415     


Val Glu Ala Leu Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala 
            420                 425                 430         


Gln Ala Gln Glu Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu 
        435                 440                 445             


Leu Asn Leu Glu Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala 
    450                 455                 460                 


Arg Gly Val Cys Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp 
465                 470                 475                 480 


Leu Ala Asp Ile Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile 
                485                 490                 495     


Met Ala Ala Arg Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala 
            500                 505                 510         


Leu Arg Thr Arg Val Lys Val Val Lys Asn Lys Ala Leu Ala Glu Gly 
        515                 520                 525             


Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr His Arg Ile Glu Asp 
    530                 535                 540                 


Val Val Asp Gly Arg Lys Pro Ile His Val Val Ala Ala Ala Lys Asp 
545                 550                 555                 560 


Gly Thr Leu His Ala Arg Pro Val Val Ser Trp Phe Asp Gln Gly Thr 
                565                 570                 575     


Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly Ala Ile Leu Trp Ala 
            580                 585                 590         


Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly Trp Arg Ala Ala Gly 
        595                 600                 605             


Glu Leu Arg Lys Gly Asp Arg Val Ala Gln Pro Arg Arg Phe Asp Gly 
    610                 615                 620                 


Phe Gly Asp Ser Ala Pro Ile Pro Ala Arg Val Gln Ala Leu Ala Asp 
625                 630                 635                 640 


Ala Leu Asp Asp Lys Phe Leu His Asp Met Leu Ala Glu Glu Leu Arg 
                645                 650                 655     


Tyr Ser Val Ile Arg Glu Val Leu Pro Thr Arg Arg Ala Arg Thr Phe 
            660                 665                 670         


Gly Leu Glu Val Glu Glu Leu His Thr Leu Val Ala Glu Gly Val Val 
        675                 680                 685             


Val His Asn Ser Ser Pro Pro Phe Lys Gln Ala Glu Phe Gly Ser Ala 
    690                 695                 700                 


Ala Ala Pro Phe Thr Met Ser Ile Ile Lys Asp Ile Ser Ser Lys Glu 
705                 710                 715                 720 


Tyr Ile Ser Phe Asn Pro Lys Glu Asn Lys Ile Thr Val Lys Ser Lys 
                725                 730                 735     


Asn Leu Pro Glu Leu Ser Thr Leu Leu Gln Glu Ile Arg Asn Asn Ser 
            740                 745                 750         


Asn Ser Ser Asp Ile Glu Leu Glu Glu Lys Val Met Leu Thr Glu Cys 
        755                 760                 765             


Glu Ile Asn Val Ile Ser Asn Ile Asp Thr Gln Ile Val Glu Glu Arg 
    770                 775                 780                 


Ile Glu Glu Ala Lys Asn Leu Thr Ser Asp Ser Ile Asn Tyr Ile Lys 
785                 790                 795                 800 


Asp Glu Phe Lys Leu Ile Glu Ser Ile Ser Asp Ala Leu Cys Asp Leu 
                805                 810                 815     


Lys Gln Gln Asn Glu Leu Glu Asp Ser His Phe Ile Ser Phe Glu Asp 
            820                 825                 830         


Ile Ser Glu Thr Asp Glu Gly Phe Ser Ile Arg Phe Ile Asn Lys Glu 
        835                 840                 845             


Thr Gly Glu Ser Ile Phe Val Glu Thr Glu Lys Thr Ile Phe Ser Glu 
    850                 855                 860                 


Tyr Ala Asn His Ile Thr Glu Glu Ile Ser Lys Ile Lys Gly Thr Ile 
865                 870                 875                 880 


Phe Asp Thr Val Asn Gly Lys Leu Val Lys Lys Val Asn Leu Asp Thr 
                885                 890                 895     


Thr His Glu Val Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu 
            900                 905                 910         


Ile Glu Tyr Asn Ser Ser Lys Glu Ser Leu Ser Asn Leu Ser Val Ala 
        915                 920                 925             


Met Lys Val Gln Val Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr 
    930                 935                 940                 


Ile Thr Asp Ala Ala Lys Val Val Glu Leu Val Ser Thr Ala Leu Asp 
945                 950                 955                 960 


Glu Thr Ile Asp Leu Leu Pro Thr Leu Ser Glu Gly Leu Pro Ile Ile 
                965                 970                 975     


Ala Thr Ile Ile Asp Gly Val Ser Leu Gly Ala Ala Ile Lys Glu Leu 
            980                 985                 990         


Ser Glu Thr Ser Asp Pro Leu Leu  Arg Gln Glu Ile Glu  Ala Lys Ile 
        995                 1000                 1005             


Gly Ile  Met Ala Val Asn Leu  Thr Thr Ala Thr Thr  Ala Ile Ile 
    1010                 1015                 1020             


Thr Ser  Ser Leu Gly Ile Ala  Ser Gly Phe Ser Ile  Leu Leu Val 
    1025                 1030                 1035             


Pro Leu  Ala Gly Ile Ser Ala  Gly Ile Pro Ser Leu  Val Asn Asn 
    1040                 1045                 1050             


Glu Leu  Val Leu Arg Asp Lys  Ala Thr Lys Val Val  Asp Tyr Phe 
    1055                 1060                 1065             


Lys His  Val Ser Leu Val Glu  Thr Glu Gly Val Phe  Thr Leu Leu 
    1070                 1075                 1080             


Asp Asp  Lys Ile Met Met Pro  Gln Asp Asp Leu Val  Ile Ser Glu 
    1085                 1090                 1095             


Ile Asp  Phe Asn Asn Asn Ser  Ile Val Leu Gly Lys  Cys Glu Ile 
    1100                 1105                 1110             


Trp Arg  Met Glu Gly Gly Ser  Gly His Thr Val Thr  Asp Asp Ile 
    1115                 1120                 1125             


Asp His  Phe Phe Ser Ala Pro  Ser Ile Thr Tyr Arg  Glu Pro His 
    1130                 1135                 1140             


Leu Ser  Ile Tyr Asp Val Leu  Glu Val Gln Lys Glu  Glu Leu Asp 
    1145                 1150                 1155             


Leu Ser  Lys Asp Leu Met Val  Leu Pro Asn Ala Pro  Asn Arg Val 
    1160                 1165                 1170             


Phe Ala  Trp Glu Thr Gly Trp  Thr Pro Gly Leu Arg  Ser Leu Glu 
    1175                 1180                 1185             


Asn Asp  Gly Thr Lys Leu Leu  Asp Arg Ile Arg Asp  Asn Tyr Glu 
    1190                 1195                 1200             


Gly Glu  Phe Tyr Trp Arg Tyr  Phe Ala Phe Ile Ala  Asp Ala Leu 
    1205                 1210                 1215             


Ile Thr  Thr Leu Lys Pro Arg  Tyr Glu Asp Thr Asn  Ile Arg Ile 
    1220                 1225                 1230             


Asn Leu  Asp Ser Asn Thr Arg  Ser Phe Ile Val Pro  Ile Ile Thr 
    1235                 1240                 1245             


Thr Glu  Tyr Ile Arg Glu Lys  Leu Ser Tyr Ser Phe  Tyr Gly Ser 
    1250                 1255                 1260             


Gly Gly  Thr Tyr Ala Leu Ser  Leu Ser Gln Tyr Asn  Met Gly Ile 
    1265                 1270                 1275             


Asn Ile  Glu Leu Ser Glu Ser  Asp Val Trp Ile Ile  Asp Val Asp 
    1280                 1285                 1290             


Asn Val  Val Arg Asp Val Thr  Ile Glu Ser Asp Lys  Ile Lys Lys 
    1295                 1300                 1305             


Gly Asp  Leu Ile Glu Gly Ile  Leu Ser Thr Leu Ser  Ile Glu Glu 
    1310                 1315                 1320             


Asn Lys  Ile Ile Leu Asn Ser  His Glu Ile Asn Phe  Ser Gly Glu 
    1325                 1330                 1335             


Val Asn  Gly Ser Asn Gly Phe  Val Ser Leu Thr Phe  Ser Ile Leu 
    1340                 1345                 1350             


Glu Gly  Ile Asn Ala Ile Ile  Glu Val Asp Leu Leu  Ser Lys Ser 
    1355                 1360                 1365             


Tyr Lys  Leu Leu Ile Ser Gly  Glu Leu Lys Ile Leu  Met Leu Asn 
    1370                 1375                 1380             


Ser Asn  His Ile Gln Gln Lys  Ile Asp Tyr Ile Gly  Phe Asn Ser 
    1385                 1390                 1395             


Glu Leu  Gln Lys Asn Ile Pro  Tyr Ser Phe Val Asp  Ser Glu Gly 
    1400                 1405                 1410             


Lys Glu  Asn Gly Phe Ile Asn  Gly Ser Thr Lys Glu  Gly Leu Phe 
    1415                 1420                 1425             


Val Ser  Glu Leu Pro Asp Val  Val Leu Ile Ser Lys  Val Tyr Met 
    1430                 1435                 1440             


Asp Asp  Ser Lys Pro Ser Phe  Gly Tyr Tyr Ser Asn  Asn Leu Lys 
    1445                 1450                 1455             


Asp Val  Lys Val Ile Thr Lys  Asp Asn Val Asn Ile  Leu Thr Gly 
    1460                 1465                 1470             


Tyr Tyr  Leu Lys Asp Asp Ile  Lys Ile Ser Leu Ser  Leu Thr Leu 
    1475                 1480                 1485             


Gln Asp  Glu Lys Thr Ile Lys  Leu Asn Ser Val His  Leu Asp Glu 
    1490                 1495                 1500             


Ser Gly  Val Ala Glu Ile Leu  Lys Phe Met Asn Arg  Lys Gly Asn 
    1505                 1510                 1515             


Thr Asn  Thr Ser Asp Ser Leu  Met Ser Phe Leu Glu  Ser Met Asn 
    1520                 1525                 1530             


Ile Lys  Ser Ile Phe Val Asn  Phe Leu Gln Ser Asn  Ile Lys Phe 
    1535                 1540                 1545             


Ile Leu  Asp Ala Asn Phe Ile  Ile Ser Gly Thr Thr  Ser Ile Gly 
    1550                 1555                 1560             


Gln Phe  Glu Phe Ile Cys Asp  Glu Asn Asp Asn Ile  Gln Pro Tyr 
    1565                 1570                 1575             


Phe Ile  Lys Phe Asn Thr Leu  Glu Thr Asn Tyr Thr  Leu Tyr Val 
    1580                 1585                 1590             


Gly Asn  Arg Gln Asn Met Ile  Val Glu Pro Asn Tyr  Asp Leu Asp 
    1595                 1600                 1605             


Asp Ser  Gly Asp Ile Ser Ser  Thr Val Ile Asn Phe  Ser Gln Lys 
    1610                 1615                 1620             


Tyr Leu  Tyr Gly Ile Asp Ser  Cys Val Asn Lys Val  Val Ile Ser 
    1625                 1630                 1635             


Pro Asn  Ile Tyr Thr Asp Glu  Ile Asn Ile Thr Pro  Val Tyr Glu 
    1640                 1645                 1650             


Thr Asn  Asn Thr Tyr Pro Glu  Val Ile Val Leu Asp  Ala Asn Tyr 
    1655                 1660                 1665             


Ile Asn  Glu Lys Ile Asn Val  Asn Ile Asn Asp Leu  Ser Ile Arg 
    1670                 1675                 1680             


Tyr Val  Trp Ser Asn Asp Gly  Asn Asp Phe Ile Leu  Met Ser Thr 
    1685                 1690                 1695             


Ser Glu  Glu Asn Lys Val Ser  Gln Val Lys Ile Arg  Phe Val Asn 
    1700                 1705                 1710             


Val Phe  Lys Asp Lys Thr Leu  Ala Asn Lys Leu Ser  Phe Asn Phe 
    1715                 1720                 1725             


Ser Asp  Lys Gln Asp Val Pro  Val Ser Glu Ile Ile  Leu Ser Phe 
    1730                 1735                 1740             


Thr Pro  Ser Tyr Tyr Glu Asp  Gly Leu Ile Gly Tyr  Asp Leu Gly 
    1745                 1750                 1755             


Leu Val  Ser Leu Tyr Asn Glu  Lys Phe Tyr Ile Asn  Asn Phe Gly 
    1760                 1765                 1770             


Met Met  Val Ser Gly Leu Ile  Tyr Ile Asn Asp Ser  Leu Tyr Tyr 
    1775                 1780                 1785             


Phe Lys  Pro Pro Val Asn Asn  Leu Ile Thr Gly Phe  Val Thr Val 
    1790                 1795                 1800             


Gly Asp  Asp Lys Tyr Tyr Phe  Asn Pro Ile Asn Gly  Gly Ala Ala 
    1805                 1810                 1815             


Ser Ile  Gly Glu Thr Ile Ile  Asp Asp Lys Asn Tyr  Tyr Phe Asn 
    1820                 1825                 1830             


Gln Ser  Gly Val Leu Gln Thr  Gly Val Phe Ser Thr  Glu Asp Gly 
    1835                 1840                 1845             


Phe Lys  Tyr Phe Ala Pro Ala  Asn Thr Leu Asp Glu  Asn Leu Glu 
    1850                 1855                 1860             


Gly Glu  Ala Ile Asp Phe Thr  Gly Lys Leu Ile Ile  Asp Glu Asn 
    1865                 1870                 1875             


Ile Tyr  Tyr Phe Asp Asp Asn  Tyr Arg Gly Ala Val  Glu Trp Lys 
    1880                 1885                 1890             


Glu Leu  Asp Gly Glu Met His  Tyr Phe Ser Pro Glu  Thr Gly Lys 
    1895                 1900                 1905             


Ala Phe  Lys Gly Leu Asn Gln  Ile Gly Asp Tyr Lys  Tyr Tyr Phe 
    1910                 1915                 1920             


Asn Ser  Asp Gly Val Met Gln  Lys Gly Phe Val Ser  Ile Asn Asp 
    1925                 1930                 1935             


Asn Lys  His Tyr Phe Asp Asp  Ser Gly Val Met Lys  Val Gly Tyr 
    1940                 1945                 1950             


Thr Glu  Ile Asp Gly Lys His  Phe Tyr Phe Ala Glu  Asn Gly Glu 
    1955                 1960                 1965             


Met Gln  Ile Gly Val Phe Asn  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1970                 1975                 1980             


Ala His  His Asn Glu Asp Leu  Gly Asn Glu Glu Gly  Glu Glu Ile 
    1985                 1990                 1995             


Ser Tyr  Ser Gly Ile Leu Asn  Phe Asn Asn Lys Ile  Tyr Tyr Phe 
    2000                 2005                 2010             


Asp Asp  Ser Phe Thr Ala Val  Val Gly Trp Lys Asp  Leu Glu Asp 
    2015                 2020                 2025             


Gly Ser  Lys Tyr Tyr Phe Asp  Glu Asp Thr Ala Glu  Ala Tyr Ile 
    2030                 2035                 2040             


Gly Leu  Ser Leu Ile Asn Asp  Gly Gln Tyr Tyr Phe  Asn Asp Asp 
    2045                 2050                 2055             


Gly Ile  Met Gln Val Gly Phe  Val Thr Ile Asn Asp  Lys Val Phe 
    2060                 2065                 2070             


Tyr Phe  Ser Asp Ser Gly Ile  Ile Glu Ser Gly Val  Gln Asn Ile 
    2075                 2080                 2085             


Asp Asp  Asn Tyr Phe Tyr Ile  Asp Asp Asn Gly Ile  Val Gln Ile 
    2090                 2095                 2100             


Gly Val  Phe Asp Thr Ser Asp  Gly Tyr Lys Tyr Phe  Ala Pro Ala 
    2105                 2110                 2115             


Asn Thr  Val Asn Asp Asn Ile  Tyr Gly Gln Ala Val  Glu Tyr Ser 
    2120                 2125                 2130             


Gly Leu  Val Arg Val Gly Glu  Asp Val Tyr Tyr Phe  Gly Glu Thr 
    2135                 2140                 2145             


Tyr Thr  Ile Glu Thr Gly Trp  Ile Tyr Asp Met Glu  Asn Glu Ser 
    2150                 2155                 2160             


Asp Lys  Tyr Tyr Phe Asn Pro  Glu Thr Lys Lys Ala  Cys Lys Gly 
    2165                 2170                 2175             


Ile Asn  Leu Ile Asp Asp Ile  Lys Tyr Tyr Phe Asp  Glu Lys Gly 
    2180                 2185                 2190             


Ile Met  Arg Thr Gly Leu Ile  Ser Phe Glu Asn Asn  Asn Tyr Tyr 
    2195                 2200                 2205             


Phe Asn  Glu Asn Gly Glu Met  Gln Phe Gly Tyr Ile  Asn Ile Glu 
    2210                 2215                 2220             


Asp Lys  Met Phe Tyr Phe Gly  Glu Asp Gly Val Met  Gln Ile Gly 
    2225                 2230                 2235             


Val Phe  Asn Thr Pro Asp Gly  Phe Lys Tyr Phe Ala  His Gln Asn 
    2240                 2245                 2250             


Thr Leu  Asp Glu Asn Phe Glu  Gly Glu Ser Ile Asn  Tyr Thr Gly 
    2255                 2260                 2265             


Trp Leu  Asp Leu Asp Glu Lys  Arg Tyr Tyr Phe Thr  Asp Glu Tyr 
    2270                 2275                 2280             


Ile Ala  Ala Thr Gly Ser Val  Ile Ile Asp Gly Glu  Glu Tyr Tyr 
    2285                 2290                 2295             


Phe Asp  Pro Asp Thr Ala Gln  Leu Val Ile Ser Glu  Gly His His 
    2300                 2305                 2310             


His His  His His 
    2315         


<210>  57
<211>  2321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  57

Met Gly Ser Ser His His His His His His Ser His Met Ala Ser Asn 
1               5                   10                  15      


Lys Glu Ile Leu Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu 
            20                  25                  30          


Pro Arg Glu Lys Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala 
        35                  40                  45              


Thr Lys Lys Lys Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp 
    50                  55                  60                  


Arg Lys Ser Gly Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp 
65                  70                  75                  80  


Glu Val Thr Gln Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr 
                85                  90                  95      


Glu Asp Glu Ser Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu 
            100                 105                 110         


Ser Val Thr Phe Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile 
        115                 120                 125             


Val Gln Lys Val Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe 
    130                 135                 140                 


Arg Glu His Glu Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn 
145                 150                 155                 160 


Arg Asp Asn Ile Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile 
                165                 170                 175     


Leu Arg Glu Asp Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg 
            180                 185                 190         


Val Arg Gly Val Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln 
        195                 200                 205             


Leu Phe Val Thr Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg 
    210                 215                 220                 


Ile Glu Val Pro Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala 
225                 230                 235                 240 


Ala Arg Asp Pro Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp 
                245                 250                 255     


Lys Arg Ile Asp Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg 
            260                 265                 270         


Val Gln Ala Val Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val 
        275                 280                 285             


Leu Trp Asp Asp Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro 
    290                 295                 300                 


Ala Asp Val Ala Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp 
305                 310                 315                 320 


Ile Ala Val Glu Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly 
                325                 330                 335     


Gln Asn Val Arg Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val 
            340                 345                 350         


Met Thr Val Asp Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala 
        355                 360                 365             


Ala Ile Asp Thr Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala 
    370                 375                 380                 


Thr Val Leu Val Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr 
385                 390                 395                 400 


Val Pro Met Lys Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr 
                405                 410                 415     


Val Glu Ala Leu Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala 
            420                 425                 430         


Gln Ala Gln Glu Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu 
        435                 440                 445             


Leu Asn Leu Glu Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala 
    450                 455                 460                 


Arg Gly Val Cys Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp 
465                 470                 475                 480 


Leu Ala Asp Ile Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile 
                485                 490                 495     


Met Ala Ala Arg Asn Ile Cys Trp Phe Gly Asp Glu Ala Ser Gly Ala 
            500                 505                 510         


Leu Glu Val Phe Gly Glu Phe Gly Ser Gly Lys Ala Phe Ala Arg Asp 
        515                 520                 525             


Thr Glu Val Tyr Tyr Glu Asn Asp Thr Val Pro His Met Glu Ser Ile 
    530                 535                 540                 


Glu Glu Met Tyr Ser Lys Tyr Ala Ser Met Asn Gly Glu Leu Pro Phe 
545                 550                 555                 560 


Asp Asn Gly Tyr Ala Val Pro Leu Asp Asn Val Phe Val Tyr Thr Leu 
                565                 570                 575     


Asp Ile Ala Ser Gly Glu Ile Lys Lys Thr Arg Ala Ser Tyr Ile Tyr 
            580                 585                 590         


Arg Glu Lys Val Glu Lys Leu Ile Glu Ile Lys Leu Ser Ser Gly Tyr 
        595                 600                 605             


Ser Leu Lys Val Thr Pro Ser His Pro Val Leu Leu Phe Arg Asp Gly 
    610                 615                 620                 


Leu Gln Trp Val Pro Ala Ala Glu Val Lys Pro Gly Asp Val Val Val 
625                 630                 635                 640 


Gly Val Arg Glu Glu Val Leu Arg Arg Arg Ile Ile Ser Lys Gly Glu 
                645                 650                 655     


Leu Glu Phe His Glu Val Ser Ser Val Arg Ile Ile Asp Tyr Asn Asn 
            660                 665                 670         


Trp Val Tyr Asp Leu Val Ile Pro Glu Thr His Asn Phe Ile Ala Pro 
        675                 680                 685             


Asn Gly Leu Val Leu His Asn Thr Gln Leu Ala His Thr Leu Ala Val 
    690                 695                 700                 


Met Gly Ser Ala Ala Ala Pro Phe Thr Met Ser Ile Ile Lys Asp Ile 
705                 710                 715                 720 


Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn Lys Ile Thr 
                725                 730                 735     


Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu Gln Glu Ile 
            740                 745                 750         


Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu Lys Val Met 
        755                 760                 765             


Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp Thr Gln Ile 
    770                 775                 780                 


Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser Asp Ser Ile 
785                 790                 795                 800 


Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile Ser Asp Ala 
                805                 810                 815     


Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser His Phe Ile 
            820                 825                 830         


Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser Ile Arg Phe 
        835                 840                 845             


Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr Glu Lys Thr 
    850                 855                 860                 


Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile Ser Lys Ile 
865                 870                 875                 880 


Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val Lys Lys Val 
                885                 890                 895     


Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala Ala Phe Phe 
            900                 905                 910         


Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser Leu Ser Asn 
        915                 920                 925             


Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu Phe Ser Thr 
    930                 935                 940                 


Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu Leu Val Ser 
945                 950                 955                 960 


Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr Leu Ser Glu Gly 
                965                 970                 975     


Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val Ser Leu Gly Ala Ala 
            980                 985                 990         


Ile Lys Glu Leu Ser Glu Thr Ser  Asp Pro Leu Leu Arg  Gln Glu Ile 
        995                 1000                 1005             


Glu Ala  Lys Ile Gly Ile Met  Ala Val Asn Leu Thr  Thr Ala Thr 
    1010                 1015                 1020             


Thr Ala  Ile Ile Thr Ser Ser  Leu Gly Ile Ala Ser  Gly Phe Ser 
    1025                 1030                 1035             


Ile Leu  Leu Val Pro Leu Ala  Gly Ile Ser Ala Gly  Ile Pro Ser 
    1040                 1045                 1050             


Leu Val  Asn Asn Glu Leu Val  Leu Arg Asp Lys Ala  Thr Lys Val 
    1055                 1060                 1065             


Val Asp  Tyr Phe Lys His Val  Ser Leu Val Glu Thr  Glu Gly Val 
    1070                 1075                 1080             


Phe Thr  Leu Leu Asp Asp Lys  Ile Met Met Pro Gln  Asp Asp Leu 
    1085                 1090                 1095             


Val Ile  Ser Glu Ile Asp Phe  Asn Asn Asn Ser Ile  Val Leu Gly 
    1100                 1105                 1110             


Lys Cys  Glu Ile Trp Arg Met  Glu Gly Gly Ser Gly  His Thr Val 
    1115                 1120                 1125             


Thr Asp  Asp Ile Asp His Phe  Phe Ser Ala Pro Ser  Ile Thr Tyr 
    1130                 1135                 1140             


Arg Glu  Pro His Leu Ser Ile  Tyr Asp Val Leu Glu  Val Gln Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Leu Ser Lys  Asp Leu Met Val Leu  Pro Asn Ala 
    1160                 1165                 1170             


Pro Asn  Arg Val Phe Ala Trp  Glu Thr Gly Trp Thr  Pro Gly Leu 
    1175                 1180                 1185             


Arg Ser  Leu Glu Asn Asp Gly  Thr Lys Leu Leu Asp  Arg Ile Arg 
    1190                 1195                 1200             


Asp Asn  Tyr Glu Gly Glu Phe  Tyr Trp Arg Tyr Phe  Ala Phe Ile 
    1205                 1210                 1215             


Ala Asp  Ala Leu Ile Thr Thr  Leu Lys Pro Arg Tyr  Glu Asp Thr 
    1220                 1225                 1230             


Asn Ile  Arg Ile Asn Leu Asp  Ser Asn Thr Arg Ser  Phe Ile Val 
    1235                 1240                 1245             


Pro Ile  Ile Thr Thr Glu Tyr  Ile Arg Glu Lys Leu  Ser Tyr Ser 
    1250                 1255                 1260             


Phe Tyr  Gly Ser Gly Gly Thr  Tyr Ala Leu Ser Leu  Ser Gln Tyr 
    1265                 1270                 1275             


Asn Met  Gly Ile Asn Ile Glu  Leu Ser Glu Ser Asp  Val Trp Ile 
    1280                 1285                 1290             


Ile Asp  Val Asp Asn Val Val  Arg Asp Val Thr Ile  Glu Ser Asp 
    1295                 1300                 1305             


Lys Ile  Lys Lys Gly Asp Leu  Ile Glu Gly Ile Leu  Ser Thr Leu 
    1310                 1315                 1320             


Ser Ile  Glu Glu Asn Lys Ile  Ile Leu Asn Ser His  Glu Ile Asn 
    1325                 1330                 1335             


Phe Ser  Gly Glu Val Asn Gly  Ser Asn Gly Phe Val  Ser Leu Thr 
    1340                 1345                 1350             


Phe Ser  Ile Leu Glu Gly Ile  Asn Ala Ile Ile Glu  Val Asp Leu 
    1355                 1360                 1365             


Leu Ser  Lys Ser Tyr Lys Leu  Leu Ile Ser Gly Glu  Leu Lys Ile 
    1370                 1375                 1380             


Leu Met  Leu Asn Ser Asn His  Ile Gln Gln Lys Ile  Asp Tyr Ile 
    1385                 1390                 1395             


Gly Phe  Asn Ser Glu Leu Gln  Lys Asn Ile Pro Tyr  Ser Phe Val 
    1400                 1405                 1410             


Asp Ser  Glu Gly Lys Glu Asn  Gly Phe Ile Asn Gly  Ser Thr Lys 
    1415                 1420                 1425             


Glu Gly  Leu Phe Val Ser Glu  Leu Pro Asp Val Val  Leu Ile Ser 
    1430                 1435                 1440             


Lys Val  Tyr Met Asp Asp Ser  Lys Pro Ser Phe Gly  Tyr Tyr Ser 
    1445                 1450                 1455             


Asn Asn  Leu Lys Asp Val Lys  Val Ile Thr Lys Asp  Asn Val Asn 
    1460                 1465                 1470             


Ile Leu  Thr Gly Tyr Tyr Leu  Lys Asp Asp Ile Lys  Ile Ser Leu 
    1475                 1480                 1485             


Ser Leu  Thr Leu Gln Asp Glu  Lys Thr Ile Lys Leu  Asn Ser Val 
    1490                 1495                 1500             


His Leu  Asp Glu Ser Gly Val  Ala Glu Ile Leu Lys  Phe Met Asn 
    1505                 1510                 1515             


Arg Lys  Gly Asn Thr Asn Thr  Ser Asp Ser Leu Met  Ser Phe Leu 
    1520                 1525                 1530             


Glu Ser  Met Asn Ile Lys Ser  Ile Phe Val Asn Phe  Leu Gln Ser 
    1535                 1540                 1545             


Asn Ile  Lys Phe Ile Leu Asp  Ala Asn Phe Ile Ile  Ser Gly Thr 
    1550                 1555                 1560             


Thr Ser  Ile Gly Gln Phe Glu  Phe Ile Cys Asp Glu  Asn Asp Asn 
    1565                 1570                 1575             


Ile Gln  Pro Tyr Phe Ile Lys  Phe Asn Thr Leu Glu  Thr Asn Tyr 
    1580                 1585                 1590             


Thr Leu  Tyr Val Gly Asn Arg  Gln Asn Met Ile Val  Glu Pro Asn 
    1595                 1600                 1605             


Tyr Asp  Leu Asp Asp Ser Gly  Asp Ile Ser Ser Thr  Val Ile Asn 
    1610                 1615                 1620             


Phe Ser  Gln Lys Tyr Leu Tyr  Gly Ile Asp Ser Cys  Val Asn Lys 
    1625                 1630                 1635             


Val Val  Ile Ser Pro Asn Ile  Tyr Thr Asp Glu Ile  Asn Ile Thr 
    1640                 1645                 1650             


Pro Val  Tyr Glu Thr Asn Asn  Thr Tyr Pro Glu Val  Ile Val Leu 
    1655                 1660                 1665             


Asp Ala  Asn Tyr Ile Asn Glu  Lys Ile Asn Val Asn  Ile Asn Asp 
    1670                 1675                 1680             


Leu Ser  Ile Arg Tyr Val Trp  Ser Asn Asp Gly Asn  Asp Phe Ile 
    1685                 1690                 1695             


Leu Met  Ser Thr Ser Glu Glu  Asn Lys Val Ser Gln  Val Lys Ile 
    1700                 1705                 1710             


Arg Phe  Val Asn Val Phe Lys  Asp Lys Thr Leu Ala  Asn Lys Leu 
    1715                 1720                 1725             


Ser Phe  Asn Phe Ser Asp Lys  Gln Asp Val Pro Val  Ser Glu Ile 
    1730                 1735                 1740             


Ile Leu  Ser Phe Thr Pro Ser  Tyr Tyr Glu Asp Gly  Leu Ile Gly 
    1745                 1750                 1755             


Tyr Asp  Leu Gly Leu Val Ser  Leu Tyr Asn Glu Lys  Phe Tyr Ile 
    1760                 1765                 1770             


Asn Asn  Phe Gly Met Met Val  Ser Gly Leu Ile Tyr  Ile Asn Asp 
    1775                 1780                 1785             


Ser Leu  Tyr Tyr Phe Lys Pro  Pro Val Asn Asn Leu  Ile Thr Gly 
    1790                 1795                 1800             


Phe Val  Thr Val Gly Asp Asp  Lys Tyr Tyr Phe Asn  Pro Ile Asn 
    1805                 1810                 1815             


Gly Gly  Ala Ala Ser Ile Gly  Glu Thr Ile Ile Asp  Asp Lys Asn 
    1820                 1825                 1830             


Tyr Tyr  Phe Asn Gln Ser Gly  Val Leu Gln Thr Gly  Val Phe Ser 
    1835                 1840                 1845             


Thr Glu  Asp Gly Phe Lys Tyr  Phe Ala Pro Ala Asn  Thr Leu Asp 
    1850                 1855                 1860             


Glu Asn  Leu Glu Gly Glu Ala  Ile Asp Phe Thr Gly  Lys Leu Ile 
    1865                 1870                 1875             


Ile Asp  Glu Asn Ile Tyr Tyr  Phe Asp Asp Asn Tyr  Arg Gly Ala 
    1880                 1885                 1890             


Val Glu  Trp Lys Glu Leu Asp  Gly Glu Met His Tyr  Phe Ser Pro 
    1895                 1900                 1905             


Glu Thr  Gly Lys Ala Phe Lys  Gly Leu Asn Gln Ile  Gly Asp Tyr 
    1910                 1915                 1920             


Lys Tyr  Tyr Phe Asn Ser Asp  Gly Val Met Gln Lys  Gly Phe Val 
    1925                 1930                 1935             


Ser Ile  Asn Asp Asn Lys His  Tyr Phe Asp Asp Ser  Gly Val Met 
    1940                 1945                 1950             


Lys Val  Gly Tyr Thr Glu Ile  Asp Gly Lys His Phe  Tyr Phe Ala 
    1955                 1960                 1965             


Glu Asn  Gly Glu Met Gln Ile  Gly Val Phe Asn Thr  Glu Asp Gly 
    1970                 1975                 1980             


Phe Lys  Tyr Phe Ala His His  Asn Glu Asp Leu Gly  Asn Glu Glu 
    1985                 1990                 1995             


Gly Glu  Glu Ile Ser Tyr Ser  Gly Ile Leu Asn Phe  Asn Asn Lys 
    2000                 2005                 2010             


Ile Tyr  Tyr Phe Asp Asp Ser  Phe Thr Ala Val Val  Gly Trp Lys 
    2015                 2020                 2025             


Asp Leu  Glu Asp Gly Ser Lys  Tyr Tyr Phe Asp Glu  Asp Thr Ala 
    2030                 2035                 2040             


Glu Ala  Tyr Ile Gly Leu Ser  Leu Ile Asn Asp Gly  Gln Tyr Tyr 
    2045                 2050                 2055             


Phe Asn  Asp Asp Gly Ile Met  Gln Val Gly Phe Val  Thr Ile Asn 
    2060                 2065                 2070             


Asp Lys  Val Phe Tyr Phe Ser  Asp Ser Gly Ile Ile  Glu Ser Gly 
    2075                 2080                 2085             


Val Gln  Asn Ile Asp Asp Asn  Tyr Phe Tyr Ile Asp  Asp Asn Gly 
    2090                 2095                 2100             


Ile Val  Gln Ile Gly Val Phe  Asp Thr Ser Asp Gly  Tyr Lys Tyr 
    2105                 2110                 2115             


Phe Ala  Pro Ala Asn Thr Val  Asn Asp Asn Ile Tyr  Gly Gln Ala 
    2120                 2125                 2130             


Val Glu  Tyr Ser Gly Leu Val  Arg Val Gly Glu Asp  Val Tyr Tyr 
    2135                 2140                 2145             


Phe Gly  Glu Thr Tyr Thr Ile  Glu Thr Gly Trp Ile  Tyr Asp Met 
    2150                 2155                 2160             


Glu Asn  Glu Ser Asp Lys Tyr  Tyr Phe Asn Pro Glu  Thr Lys Lys 
    2165                 2170                 2175             


Ala Cys  Lys Gly Ile Asn Leu  Ile Asp Asp Ile Lys  Tyr Tyr Phe 
    2180                 2185                 2190             


Asp Glu  Lys Gly Ile Met Arg  Thr Gly Leu Ile Ser  Phe Glu Asn 
    2195                 2200                 2205             


Asn Asn  Tyr Tyr Phe Asn Glu  Asn Gly Glu Met Gln  Phe Gly Tyr 
    2210                 2215                 2220             


Ile Asn  Ile Glu Asp Lys Met  Phe Tyr Phe Gly Glu  Asp Gly Val 
    2225                 2230                 2235             


Met Gln  Ile Gly Val Phe Asn  Thr Pro Asp Gly Phe  Lys Tyr Phe 
    2240                 2245                 2250             


Ala His  Gln Asn Thr Leu Asp  Glu Asn Phe Glu Gly  Glu Ser Ile 
    2255                 2260                 2265             


Asn Tyr  Thr Gly Trp Leu Asp  Leu Asp Glu Lys Arg  Tyr Tyr Phe 
    2270                 2275                 2280             


Thr Asp  Glu Tyr Ile Ala Ala  Thr Gly Ser Val Ile  Ile Asp Gly 
    2285                 2290                 2295             


Glu Glu  Tyr Tyr Phe Asp Pro  Asp Thr Ala Gln Leu  Val Ile Ser 
    2300                 2305                 2310             


Glu Gly  His His His His His  His 
    2315                 2320     


<210>  58
<211>  2099
<212>  PRT
<213>  Clostridium difficile

<400>  58

Met Gly Ser Ser His His His His His His Ser His Met Ala Ser Asp 
1               5                   10                  15      


Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys 
            20                  25                  30          


Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro 
        35                  40                  45              


Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln 
    50                  55                  60                  


Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr 
65                  70                  75                  80  


Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys 
                85                  90                  95      


Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln 
            100                 105                 110         


Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Arg Ala Leu Glu Val Leu 
        115                 120                 125             


Phe Gln Gly Pro Gly Gly Ser Ala Asp Ala Arg Ala Lys Ala Gln Phe 
    130                 135                 140                 


Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ala Gly Gly Ser Ile Met 
145                 150                 155                 160 


Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile Asp Asn 
                165                 170                 175     


Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser Ile Ser 
            180                 185                 190         


Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro Asp Thr 
        195                 200                 205             


Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser Ile Gly 
    210                 215                 220                 


Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile Ile His 
225                 230                 235                 240 


Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu Asn Val 
                245                 250                 255     


Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp Glu Lys 
            260                 265                 270         


Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr Tyr Ser 
        275                 280                 285             


Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val Glu Thr 
    290                 295                 300                 


Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys Glu Ile 
305                 310                 315                 320 


Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn Leu Leu 
                325                 330                 335     


Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu Asn Ala 
            340                 345                 350         


Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys Asp Val 
        355                 360                 365             


Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala Gln Leu 
    370                 375                 380                 


Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu Val Asn 
385                 390                 395                 400 


Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu Pro Thr Ile 
                405                 410                 415     


Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp Gly Ile Asn Leu 
            420                 425                 430         


Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His Asp Pro Leu Leu Lys 
        435                 440                 445             


Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala Ile Asn Met Ser Leu 
    450                 455                 460                 


Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly Ile Gly Ala Glu Val 
465                 470                 475                 480 


Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser Ala Gly Ile Pro Ser 
                485                 490                 495     


Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys Ala Thr Ser Val Val 
            500                 505                 510         


Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys 
        515                 520                 525             


Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser 
    530                 535                 540                 


Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile 
545                 550                 555                 560 


Leu Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp 
                565                 570                 575     


His Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser 
            580                 585                 590         


Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys 
        595                 600                 605             


Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp Glu 
    610                 615                 620                 


Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Arg 
625                 630                 635                 640 


Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr Trp Arg 
                645                 650                 655     


Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys Pro Val Tyr 
            660                 665                 670         


Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp Thr Arg Asn Phe 
        675                 680                 685             


Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg Asn Lys Leu Ser Tyr 
    690                 695                 700                 


Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu Ser Ser Tyr 
705                 710                 715                 720 


Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp Asp Leu Trp Ile Phe 
                725                 730                 735     


Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile 
            740                 745                 750         


Lys Lys Gly Lys Leu Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn 
        755                 760                 765             


Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp 
    770                 775                 780                 


Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp 
785                 790                 795                 800 


Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser 
                805                 810                 815     


Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn 
            820                 825                 830         


Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala 
        835                 840                 845             


Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile Ser 
    850                 855                 860                 


Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser Lys Asn 
865                 870                 875                 880 


Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn Ser Lys Asp 
                885                 890                 895     


Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp Ile Asn Thr 
            900                 905                 910         


Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser Ile Asp 
        915                 920                 925             


Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val Asn Gly Leu 
    930                 935                 940                 


Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val Lys Asn 
945                 950                 955                 960 


Ser Asp Gly His His Asn Thr Ser Asn Phe Met Asn Leu Phe Leu Asp 
                965                 970                 975     


Asn Ile Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile Asn Phe Val 
            980                 985                 990         


Ile Asp Lys Tyr Phe Thr Leu Val  Gly Lys Thr Asn Leu  Gly Tyr Val 
        995                 1000                 1005             


Glu Phe  Ile Cys Asp Asn Asn  Lys Asn Ile Asp Ile  Tyr Phe Gly 
    1010                 1015                 1020             


Glu Trp  Lys Thr Ser Ser Ser  Lys Ser Thr Ile Phe  Ser Gly Asn 
    1025                 1030                 1035             


Gly Arg  Asn Val Val Val Glu  Pro Ile Tyr Asn Pro  Asp Thr Gly 
    1040                 1045                 1050             


Glu Asp  Ile Ser Thr Ser Leu  Asp Phe Ser Tyr Glu  Pro Leu Tyr 
    1055                 1060                 1065             


Gly Ile  Asp Arg Tyr Ile Asn  Lys Val Leu Ile Ala  Pro Asp Leu 
    1070                 1075                 1080             


Tyr Thr  Ser Leu Ile Asn Ile  Asn Thr Asn Tyr Tyr  Ser Asn Glu 
    1085                 1090                 1095             


Tyr Tyr  Pro Glu Ile Ile Val  Leu Asn Pro Asn Thr  Phe His Lys 
    1100                 1105                 1110             


Lys Val  Asn Ile Asn Leu Asp  Ser Ser Ser Phe Glu  Tyr Lys Trp 
    1115                 1120                 1125             


Ser Thr  Glu Gly Ser Asp Phe  Ile Leu Val Arg Tyr  Leu Glu Glu 
    1130                 1135                 1140             


Ser Asn  Lys Lys Ile Leu Gln  Lys Ile Arg Ile Lys  Gly Ile Leu 
    1145                 1150                 1155             


Ser Asn  Thr Gln Ser Phe Asn  Lys Met Ser Ile Asp  Phe Lys Asp 
    1160                 1165                 1170             


Ile Lys  Lys Leu Ser Leu Gly  Tyr Ile Met Ser Asn  Phe Lys Ser 
    1175                 1180                 1185             


Phe Asn  Ser Glu Asn Glu Leu  Asp Arg Asp His Leu  Gly Phe Lys 
    1190                 1195                 1200             


Ile Ile  Asp Asn Lys Thr Tyr  Tyr Tyr Asp Glu Asp  Ser Lys Leu 
    1205                 1210                 1215             


Val Lys  Gly Leu Ile Asn Ile  Asn Asn Ser Leu Phe  Tyr Phe Asp 
    1220                 1225                 1230             


Pro Ile  Glu Phe Asn Leu Val  Thr Gly Trp Gln Thr  Ile Asn Gly 
    1235                 1240                 1245             


Lys Lys  Tyr Tyr Phe Asp Ile  Asn Thr Gly Ala Ala  Leu Ile Ser 
    1250                 1255                 1260             


Tyr Lys  Ile Ile Asn Gly Lys  His Phe Tyr Phe Asn  Asn Asp Gly 
    1265                 1270                 1275             


Val Met  Gln Leu Gly Val Phe  Lys Gly Pro Asp Gly  Phe Glu Tyr 
    1280                 1285                 1290             


Phe Ala  Pro Ala Asn Thr Gln  Asn Asn Asn Ile Glu  Gly Gln Ala 
    1295                 1300                 1305             


Ile Val  Tyr Gln Ser Lys Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr 
    1310                 1315                 1320             


Tyr Phe  Asp Asn Asp Ser Lys  Ala Val Thr Gly Trp  Arg Ile Ile 
    1325                 1330                 1335             


Asn Asn  Glu Lys Tyr Tyr Phe  Asn Pro Asn Asn Ala  Ile Ala Ala 
    1340                 1345                 1350             


Val Gly  Leu Gln Val Ile Asp  Asn Asn Lys Tyr Tyr  Phe Asn Pro 
    1355                 1360                 1365             


Asp Thr  Ala Ile Ile Ser Lys  Gly Trp Gln Thr Val  Asn Gly Ser 
    1370                 1375                 1380             


Arg Tyr  Tyr Phe Asp Thr Asp  Thr Ala Ile Ala Phe  Asn Gly Tyr 
    1385                 1390                 1395             


Lys Thr  Ile Asp Gly Lys His  Phe Tyr Phe Asp Ser  Asp Cys Val 
    1400                 1405                 1410             


Val Lys  Ile Gly Val Phe Ser  Thr Ser Asn Gly Phe  Glu Tyr Phe 
    1415                 1420                 1425             


Ala Pro  Ala Asn Thr Tyr Asn  Asn Asn Ile Glu Gly  Gln Ala Ile 
    1430                 1435                 1440             


Val Tyr  Gln Ser Lys Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr 
    1445                 1450                 1455             


Phe Asp  Asn Asn Ser Lys Ala  Val Thr Gly Trp Gln  Thr Ile Asp 
    1460                 1465                 1470             


Ser Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr Ala Glu  Ala Ala Thr 
    1475                 1480                 1485             


Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn 
    1490                 1495                 1500             


Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys 
    1505                 1510                 1515             


Tyr Tyr  Phe Asn Thr Asn Thr  Ala Ile Ala Ser Thr  Gly Tyr Thr 
    1520                 1525                 1530             


Ile Ile  Asn Gly Lys His Phe  Tyr Phe Asn Thr Asp  Gly Ile Met 
    1535                 1540                 1545             


Gln Ile  Gly Val Phe Lys Gly  Pro Asn Gly Phe Glu  Tyr Phe Ala 
    1550                 1555                 1560             


Pro Ala  Asn Thr Asp Ala Asn  Asn Ile Glu Gly Gln  Ala Ile Leu 
    1565                 1570                 1575             


Tyr Gln  Asn Glu Phe Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe 
    1580                 1585                 1590             


Gly Ser  Asp Ser Lys Ala Val  Thr Gly Trp Arg Ile  Ile Asn Asn 
    1595                 1600                 1605             


Lys Lys  Tyr Tyr Phe Asn Pro  Asn Asn Ala Ile Ala  Ala Ile His 
    1610                 1615                 1620             


Leu Cys  Thr Ile Asn Asn Asp  Lys Tyr Tyr Phe Ser  Tyr Asp Gly 
    1625                 1630                 1635             


Ile Leu  Gln Asn Gly Tyr Ile  Thr Ile Glu Arg Asn  Asn Phe Tyr 
    1640                 1645                 1650             


Phe Asp  Ala Asn Asn Glu Ser  Lys Met Val Thr Gly  Val Phe Lys 
    1655                 1660                 1665             


Gly Pro  Asn Gly Phe Glu Tyr  Phe Ala Pro Ala Asn  Thr His Asn 
    1670                 1675                 1680             


Asn Asn  Ile Glu Gly Gln Ala  Ile Val Tyr Gln Asn  Lys Phe Leu 
    1685                 1690                 1695             


Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Asp Asn Asp  Ser Lys Ala 
    1700                 1705                 1710             


Val Thr  Gly Trp Gln Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn 
    1715                 1720                 1725             


Leu Asn  Thr Ala Glu Ala Ala  Thr Gly Trp Gln Thr  Ile Asp Gly 
    1730                 1735                 1740             


Lys Lys  Tyr Tyr Phe Asn Leu  Asn Thr Ala Glu Ala  Ala Thr Gly 
    1745                 1750                 1755             


Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr 
    1760                 1765                 1770             


Phe Ile  Ala Ser Thr Gly Tyr  Thr Ser Ile Asn Gly  Lys His Phe 
    1775                 1780                 1785             


Tyr Phe  Asn Thr Asp Gly Ile  Met Gln Ile Gly Val  Phe Lys Gly 
    1790                 1795                 1800             


Pro Asn  Gly Phe Glu Tyr Phe  Ala Pro Ala Asn Thr  His Asn Asn 
    1805                 1810                 1815             


Asn Ile  Glu Gly Gln Ala Ile  Leu Tyr Gln Asn Lys  Phe Leu Thr 
    1820                 1825                 1830             


Leu Asn  Gly Lys Lys Tyr Tyr  Phe Gly Ser Asp Ser  Lys Ala Val 
    1835                 1840                 1845             


Thr Gly  Leu Arg Thr Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr 
    1850                 1855                 1860             


Asn Thr  Ala Val Ala Val Thr  Gly Trp Gln Thr Ile  Asn Gly Lys 
    1865                 1870                 1875             


Lys Tyr  Tyr Phe Asn Thr Asn  Thr Ser Ile Ala Ser  Thr Gly Tyr 
    1880                 1885                 1890             


Thr Ile  Ile Ser Gly Lys His  Phe Tyr Phe Asn Thr  Asp Gly Ile 
    1895                 1900                 1905             


Met Gln  Ile Gly Val Phe Lys  Gly Pro Asp Gly Phe  Glu Tyr Phe 
    1910                 1915                 1920             


Ala Pro  Ala Asn Thr Asp Ala  Asn Asn Ile Glu Gly  Gln Ala Ile 
    1925                 1930                 1935             


Arg Tyr  Gln Asn Arg Phe Leu  Tyr Leu His Asp Asn  Ile Tyr Tyr 
    1940                 1945                 1950             


Phe Gly  Asn Asn Ser Lys Ala  Ala Thr Gly Trp Val  Thr Ile Asp 
    1955                 1960                 1965             


Gly Asn  Arg Tyr Tyr Phe Glu  Pro Asn Thr Ala Met  Gly Ala Asn 
    1970                 1975                 1980             


Gly Tyr  Lys Thr Ile Asp Asn  Lys Asn Phe Tyr Phe  Arg Asn Gly 
    1985                 1990                 1995             


Leu Pro  Gln Ile Gly Val Phe  Lys Gly Ser Asn Gly  Phe Glu Tyr 
    2000                 2005                 2010             


Phe Ala  Pro Ala Asn Thr Asp  Ala Asn Asn Ile Glu  Gly Gln Ala 
    2015                 2020                 2025             


Ile Arg  Tyr Gln Asn Arg Phe  Leu His Leu Leu Gly  Lys Ile Tyr 
    2030                 2035                 2040             


Tyr Phe  Gly Asn Asn Ser Lys  Ala Val Thr Gly Trp  Gln Thr Ile 
    2045                 2050                 2055             


Asn Gly  Lys Val Tyr Tyr Phe  Met Pro Asp Thr Ala  Met Ala Ala 
    2060                 2065                 2070             


Ala Gly  Gly Leu Phe Glu Ile  Asp Gly Val Ile Tyr  Phe Phe Gly 
    2075                 2080                 2085             


Val Asp  Gly Val Lys Ala Pro  Gly Ile Tyr Gly 
    2090                 2095                 


<210>  59
<211>  1783
<212>  PRT
<213>  Clostridium difficile

<400>  59

Met Gly Ser Ser His His His His His His Ser His Met Ala Ser Asp 
1               5                   10                  15      


Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys 
            20                  25                  30          


Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro 
        35                  40                  45              


Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln 
    50                  55                  60                  


Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr 
65                  70                  75                  80  


Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys 
                85                  90                  95      


Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln 
            100                 105                 110         


Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Arg Ala Leu Val Pro Arg 
        115                 120                 125             


Gly Ser Gly Gly Ser Ala Asp Ala Arg Ala Lys Ala Gln Phe Glu Glu 
    130                 135                 140                 


Tyr Lys Arg Asn Tyr Phe Glu Gly Ala Gly Gly Ser Ala Ala Ala Pro 
145                 150                 155                 160 


Phe Thr Met Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe 
                165                 170                 175     


Asp Ser Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly 
            180                 185                 190         


Leu Ala Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser 
        195                 200                 205             


Val Ser Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile 
    210                 215                 220                 


Glu Ser Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val 
225                 230                 235                 240 


Lys Asn Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn 
                245                 250                 255     


Leu Leu Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn 
            260                 265                 270         


Asn Leu Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn 
        275                 280                 285             


Asn Ser Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser 
    290                 295                 300                 


Val Tyr Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His 
305                 310                 315                 320 


Ile Thr Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val 
                325                 330                 335     


Asn Gly Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val 
            340                 345                 350         


Asn Thr Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser 
        355                 360                 365             


Ser Asn Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln 
    370                 375                 380                 


Leu Tyr Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser 
385                 390                 395                 400 


Ile Gln Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn 
                405                 410                 415     


Val Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu 
            420                 425                 430         


Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His 
        435                 440                 445             


Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala 
    450                 455                 460                 


Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly 
465                 470                 475                 480 


Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser 
                485                 490                 495     


Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys 
            500                 505                 510         


Ala Thr Ser Val Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Lys 
        515                 520                 525             


Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp 
    530                 535                 540                 


Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu 
545                 550                 555                 560 


Gly Thr Cys Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val 
                565                 570                 575     


Thr Gly Asn Ile Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His 
            580                 585                 590         


Ile Pro Ser Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn 
        595                 600                 605             


Leu Asp Phe Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg 
    610                 615                 620                 


Val Phe Trp Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu 
625                 630                 635                 640 


Asn Asp Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly 
                645                 650                 655     


Lys Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr 
            660                 665                 670         


Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys 
        675                 680                 685             


Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg 
    690                 695                 700                 


Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu 
705                 710                 715                 720 


Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp 
                725                 730                 735     


Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile 
            740                 745                 750         


Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile Lys Asp Val Leu Ser 
        755                 760                 765             


Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile 
    770                 775                 780                 


Asp Phe Ser Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr 
785                 790                 795                 800 


Cys Glu Leu Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val 
                805                 810                 815     


Ala Lys Ser Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile 
            820                 825                 830         


Ser Asn Leu Ser Asn Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp 
        835                 840                 845             


Ser Lys Asn Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr 
    850                 855                 860                 


Phe Gly Ala Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys 
865                 870                 875                 880 


Lys Asp Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu 
                885                 890                 895     


Phe Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys 
            900                 905                 910         


Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr 
        915                 920                 925             


Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val 
    930                 935                 940                 


Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu 
945                 950                 955                 960 


Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser Asn Phe Met 
                965                 970                 975     


Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu Phe Gly Phe Glu 
            980                 985                 990         


Asn Ile Asn Phe Val Ile Asp Lys  Tyr Phe Thr Leu Val  Gly Lys Thr 
        995                 1000                 1005             


Asn Leu  Gly Tyr Val Glu Phe  Ile Cys Asp Asn Asn  Lys Asn Ile 
    1010                 1015                 1020             


Asp Ile  Tyr Phe Gly Glu Trp  Lys Thr Ser Ser Ser  Lys Ser Thr 
    1025                 1030                 1035             


Ile Phe  Ser Gly Asn Gly Arg  Asn Val Val Val Glu  Pro Ile Tyr 
    1040                 1045                 1050             


Asn Pro  Asp Thr Gly Glu Asp  Ile Ser Thr Ser Leu  Asp Phe Ser 
    1055                 1060                 1065             


Tyr Glu  Pro Leu Tyr Gly Ile  Asp Arg Tyr Ile Asn  Lys Val Leu 
    1070                 1075                 1080             


Ile Ala  Pro Asp Leu Tyr Thr  Ser Leu Ile Asn Ile  Asn Thr Asn 
    1085                 1090                 1095             


Tyr Tyr  Ser Asn Glu Tyr Tyr  Pro Glu Ile Ile Val  Leu Asn Pro 
    1100                 1105                 1110             


Asn Thr  Phe His Lys Lys Val  Asn Ile Asn Leu Asp  Ser Ser Ser 
    1115                 1120                 1125             


Phe Glu  Tyr Lys Trp Ser Thr  Glu Gly Ser Asp Phe  Ile Leu Val 
    1130                 1135                 1140             


Arg Tyr  Leu Glu Glu Ser Asn  Lys Lys Ile Leu Gln  Lys Ile Arg 
    1145                 1150                 1155             


Ile Lys  Gly Ile Leu Ser Asn  Thr Gln Ser Phe Asn  Lys Met Ser 
    1160                 1165                 1170             


Ile Asp  Phe Lys Asp Ile Lys  Lys Leu Ser Leu Gly  Tyr Ile Met 
    1175                 1180                 1185             


Ser Asn  Phe Lys Ser Phe Asn  Ser Glu Asn Glu Leu  Asp Arg Asp 
    1190                 1195                 1200             


His Leu  Gly Phe Lys Ile Ile  Asp Asn Lys Thr Tyr  Tyr Tyr Asp 
    1205                 1210                 1215             


Glu Asp  Ser Lys Leu Val Lys  Gly Leu Ile Asn Ile  Asn Asn Ser 
    1220                 1225                 1230             


Leu Phe  Tyr Phe Asp Pro Ile  Glu Phe Asn Leu Val  Thr Gly Trp 
    1235                 1240                 1245             


Gln Thr  Ile Asn Gly Lys Lys  Tyr Tyr Phe Asp Ile  Asn Thr Gly 
    1250                 1255                 1260             


Ala Ala  Leu Ile Ser Tyr Lys  Ile Ile Asn Gly Lys  His Phe Tyr 
    1265                 1270                 1275             


Phe Asn  Asn Asp Gly Val Met  Gln Leu Gly Val Phe  Lys Gly Pro 
    1280                 1285                 1290             


Asp Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn Thr Gln  Asn Asn Asn 
    1295                 1300                 1305             


Ile Glu  Gly Gln Ala Ile Val  Tyr Gln Ser Lys Phe  Leu Thr Leu 
    1310                 1315                 1320             


Asn Gly  Lys Lys Tyr Tyr Phe  Asp Asn Asp Ser Lys  Ala Val Thr 
    1325                 1330                 1335             


Gly Trp  Arg Ile Ile Asn Asn  Glu Lys Tyr Tyr Phe  Asn Pro Asn 
    1340                 1345                 1350             


Asn Ala  Ile Ala Ala Val Gly  Leu Gln Val Ile Asp  Asn Asn Lys 
    1355                 1360                 1365             


Tyr Tyr  Phe Asn Pro Asp Thr  Ala Ile Ile Ser Lys  Gly Trp Gln 
    1370                 1375                 1380             


Thr Val  Asn Gly Ser Arg Tyr  Tyr Phe Asp Thr Asp  Thr Ala Ile 
    1385                 1390                 1395             


Ala Phe  Asn Gly Tyr Lys Thr  Ile Asp Gly Lys His  Phe Tyr Phe 
    1400                 1405                 1410             


Asp Ser  Asp Cys Val Val Lys  Ile Gly Val Phe Ser  Thr Ser Asn 
    1415                 1420                 1425             


Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr Tyr Asn  Asn Asn Ile 
    1430                 1435                 1440             


Glu Gly  Gln Ala Ile Val Tyr  Gln Ser Lys Phe Leu  Thr Leu Asn 
    1445                 1450                 1455             


Gly Lys  Lys Tyr Tyr Phe Asp  Asn Asn Ser Lys Ala  Val Thr Gly 
    1460                 1465                 1470             


Trp Gln  Thr Ile Asp Ser Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr 
    1475                 1480                 1485             


Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile Asp Gly  Lys Lys Tyr 
    1490                 1495                 1500             


Tyr Phe  Asn Thr Asn Thr Ala  Glu Ala Ala Thr Gly  Trp Gln Thr 
    1505                 1510                 1515             


Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr Asn Thr  Ala Ile Ala 
    1520                 1525                 1530             


Ser Thr  Gly Tyr Thr Ile Ile  Asn Gly Lys His Phe  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Asp  Gly Ile Met Gln Ile  Gly Val Phe Lys Gly  Pro Asn Gly 
    1550                 1555                 1560             


Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr Asp Ala Asn  Asn Ile Glu 
    1565                 1570                 1575             


Gly Gln  Ala Ile Leu Tyr Gln  Asn Glu Phe Leu Thr  Leu Asn Gly 
    1580                 1585                 1590             


Lys Lys  Tyr Tyr Phe Gly Ser  Asp Ser Lys Ala Val  Thr Gly Trp 
    1595                 1600                 1605             


Arg Ile  Ile Asn Asn Lys Lys  Tyr Tyr Phe Asn Pro  Asn Asn Ala 
    1610                 1615                 1620             


Ile Ala  Ala Ile His Leu Cys  Thr Ile Asn Asn Asp  Lys Tyr Tyr 
    1625                 1630                 1635             


Phe Ser  Tyr Asp Gly Ile Leu  Gln Asn Gly Tyr Ile  Thr Ile Glu 
    1640                 1645                 1650             


Arg Asn  Asn Phe Tyr Phe Asp  Ala Asn Asn Glu Ser  Lys Met Val 
    1655                 1660                 1665             


Thr Gly  Val Phe Lys Gly Pro  Asn Gly Phe Glu Tyr  Phe Ala Pro 
    1670                 1675                 1680             


Ala Asn  Thr His Asn Asn Asn  Ile Glu Gly Gln Ala  Ile Val Tyr 
    1685                 1690                 1695             


Gln Asn  Lys Phe Leu Thr Leu  Asn Gly Lys Lys Tyr  Tyr Phe Asp 
    1700                 1705                 1710             


Asn Asp  Ser Lys Ala Val Thr  Gly Trp Gln Thr Ile  Asp Gly Lys 
    1715                 1720                 1725             


Lys Tyr  Tyr Phe Asn Leu Asn  Thr Ala Glu Ala Ala  Thr Gly Trp 
    1730                 1735                 1740             


Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe Asn Leu  Asn Thr Ala 
    1745                 1750                 1755             


Glu Ala  Ala Thr Gly Trp Gln  Thr Ile Asp Gly Lys  Lys Tyr Tyr 
    1760                 1765                 1770             


Phe Asn  Thr Asn Thr Phe Ile  Ala Ser Thr 
    1775                 1780             


<210>  60
<211>  31
<212>  PRT
<213>  Clostridium difficile

<400>  60

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn 
1               5                   10                  15      


Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser 
            20                  25                  30      


<210>  61
<211>  157
<212>  PRT
<213>  Clostridium difficile

<400>  61

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile 
1               5                   10                  15      


Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn Gly Lys His 
            20                  25                  30          


Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly Val Phe Lys Gly 
        35                  40                  45              


Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Gln Asn Asn Asn 
    50                  55                  60                  


Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn 
65                  70                  75                  80  


Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Trp 
                85                  90                  95      


Arg Ile Ile Asn Asn Glu Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile 
            100                 105                 110         


Ala Ala Val Gly Leu Gln Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn 
        115                 120                 125             


Pro Asp Thr Ala Ile Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser 
    130                 135                 140                 


Arg Tyr Tyr Phe Asp Thr Asp Thr Ala Ile Ala Phe Asn 
145                 150                 155         


<210>  62
<211>  31
<212>  PRT
<213>  Clostridium difficile

<400>  62

Gly Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn 
1               5                   10                  15      


Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser 
            20                  25                  30      


<210>  63
<211>  134
<212>  PRT
<213>  Clostridium difficile

<400>  63

Gly Tyr Lys Thr Ile Asp Gly Lys His Phe Tyr Phe Asp Ser Asp Cys 
1               5                   10                  15      


Val Val Lys Ile Gly Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe 
            20                  25                  30          


Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val 
        35                  40                  45              


Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp 
    50                  55                  60                  


Asn Asn Ser Lys Ala Val Thr Gly Leu Gln Thr Ile Asp Ser Lys Lys 
65                  70                  75                  80  


Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr 
                85                  90                  95      


Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala 
            100                 105                 110         


Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn 
        115                 120                 125             


Thr Ala Ile Ala Ser Thr 
    130                 


<210>  64
<211>  31
<212>  PRT
<213>  Clostridium difficile

<400>  64

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn 
1               5                   10                  15      


Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn 
            20                  25                  30      


<210>  65
<211>  112
<212>  PRT
<213>  Clostridium difficile

<400>  65

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly 
1               5                   10                  15      


Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe 
            20                  25                  30          


Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu 
        35                  40                  45              


Tyr Gln Asn Glu Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly 
    50                  55                  60                  


Ser Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys 
65                  70                  75                  80  


Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr 
                85                  90                  95      


Ile Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn 
            100                 105                 110         


<210>  66
<211>  31
<212>  PRT
<213>  Clostridium difficile

<400>  66

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn 
1               5                   10                  15      


Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn 
            20                  25                  30      


<210>  67
<211>  136
<212>  PRT
<213>  Clostridium difficile

<400>  67

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn 
1               5                   10                  15      


Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu 
            20                  25                  30          


Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala 
        35                  40                  45              


Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr 
    50                  55                  60                  


Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly 
65                  70                  75                  80  


Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp 
                85                  90                  95      


Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu 
            100                 105                 110         


Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn 
        115                 120                 125             


Thr Asn Thr Phe Ile Ala Ser Thr 
    130                 135     


<210>  68
<211>  31
<212>  PRT
<213>  Clostridium difficile

<400>  68

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn 
1               5                   10                  15      


Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn 
            20                  25                  30      


<210>  69
<211>  113
<212>  PRT
<213>  Clostridium difficile

<400>  69

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly 
1               5                   10                  15      


Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe 
            20                  25                  30          


Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu 
        35                  40                  45              


Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly 
    50                  55                  60                  


Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys 
65                  70                  75                  80  


Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr 
                85                  90                  95      


Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser 
            100                 105                 110         


Thr 
    


<210>  70
<211>  31
<212>  PRT
<213>  Clostridium difficile

<400>  70

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn 
1               5                   10                  15      


Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn 
            20                  25                  30      


<210>  71
<211>  92
<212>  PRT
<213>  Clostridium difficile

<400>  71

Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly 
1               5                   10                  15      


Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe 
            20                  25                  30          


Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg 
        35                  40                  45              


Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly 
    50                  55                  60                  


Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg 
65                  70                  75                  80  


Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn 
                85                  90          


<210>  72
<211>  31
<212>  PRT
<213>  Clostridium difficile

<400>  72

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn 
1               5                   10                  15      


Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn 
            20                  25                  30      


<210>  73
<211>  116
<212>  PRT
<213>  Clostridium difficile

<400>  73

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu 
1               5                   10                  15      


Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala 
            20                  25                  30          


Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr 
        35                  40                  45              


Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn 
    50                  55                  60                  


Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr 
65                  70                  75                  80  


Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu 
                85                  90                  95      


Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro 
            100                 105                 110         


Gly Ile Tyr Gly 
        115     


<210>  74
<211>  147
<212>  PRT
<213>  Clostridium difficile

<400>  74

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile 
1               5                   10                  15      


Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly 
            20                  25                  30          


Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe 
        35                  40                  45              


Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp 
    50                  55                  60                  


Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp 
65                  70                  75                  80  


Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His 
                85                  90                  95      


Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile 
            100                 105                 110         


Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly 
        115                 120                 125             


Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val 
    130                 135                 140                 


Met Lys Val 
145         


<210>  75
<211>  147
<212>  PRT
<213>  Clostridium difficile

<400>  75

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile 
1               5                   10                  15      


Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly 
            20                  25                  30          


Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe 
        35                  40                  45              


Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp 
    50                  55                  60                  


Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp 
65                  70                  75                  80  


Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His 
                85                  90                  95      


Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile 
            100                 105                 110         


Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly 
        115                 120                 125             


Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val 
    130                 135                 140                 


Met Lys Val 
145         


<210>  76
<211>  30
<212>  PRT
<213>  Clostridium difficile

<400>  76

Gly Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn 
1               5                   10                  15      


Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser 
            20                  25                  30  


<210>  77
<211>  132
<212>  PRT
<213>  Clostridium difficile

<400>  77

Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly 
1               5                   10                  15      


Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe 
            20                  25                  30          


Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser 
        35                  40                  45              


Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp 
    50                  55                  60                  


Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu 
                85                  90                  95      


Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val 
            100                 105                 110         


Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly 
        115                 120                 125             


Ile Ile Glu Ser 
    130         


<210>  78
<211>  30
<212>  PRT
<213>  Clostridium difficile

<400>  78

Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn 
1               5                   10                  15      


Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser 
            20                  25                  30  


<210>  79
<211>  134
<212>  PRT
<213>  Clostridium difficile

<400>  79

Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile Asp Asp Asn Gly 
1               5                   10                  15      


Ile Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe 
            20                  25                  30          


Ala Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu 
        35                  40                  45              


Tyr Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu 
    50                  55                  60                  


Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser 
65                  70                  75                  80  


Asp Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile 
                85                  90                  95      


Asn Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met 
            100                 105                 110         


Arg Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu 
        115                 120                 125             


Asn Gly Glu Met Gln Phe 
    130                 


<210>  80
<211>  30
<212>  PRT
<213>  Clostridium difficile

<400>  80

Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn 
1               5                   10                  15      


Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr 
            20                  25                  30  


<210>  81
<211>  93
<212>  PRT
<213>  Clostridium difficile

<400>  81

Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly 
1               5                   10                  15      


Val Met Gln Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe 
            20                  25                  30          


Ala His Gln Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn 
        35                  40                  45              


Tyr Thr Gly Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp 
    50                  55                  60                  


Glu Tyr Ile Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr 
65                  70                  75                  80  


Tyr Phe Asp Pro Asp Thr Ala Gln Leu Val Ile Ser Glu 
                85                  90              


