                         SEQUENCE LISTING

<110>  aTyr Pharma, Inc.
       Pangu Biopharma Limited 
       Leslie, Greene Ann
       Kyle, Chiang P.
       Hong, Fei
       Vasserot, Alain P.
       Lo, Wing-Sze
       Watkins, Jeffry D.
       Quinn, Cheryl L.
       Mendlein, John D.
     
 
<120>  INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY 
       COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TRYPTOPHANYL TRNA 
       SYNTHETASES

<130>  ATYR-088/01WO

<160>  230   

<170>  PatentIn version 3.5

<210>  1
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  1
aggaggtaaa acatatgcat catcatcatc atcacggtaa gcctatccct aaccctttgc       60

tcggtctcga ttctacg                                                      77


<210>  2
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  2
taatgactcg ag                                                           12


<210>  3
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Olignonucleotide

<400>  3
aggagataaa acatatg                                                      17


<210>  4
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  4
aggaggtaaa acat                                                         14


<210>  5
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  5
aggagataaa acat                                                         14


<210>  6
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  6
gaaggagata tacat                                                        15


<210>  7
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  7
ggtaagccta tccctaaccc tctcctcggt ctcgattcta cgcaccacca tcatcaccat       60

taatgactcg ag                                                           72


<210>  8
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  8
catatgcatc atcatcatca tcacggtaag cctatcccta accctctcct cggtctcgat       60

tctacgggat cc                                                           72


<210>  9
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  9
ctcgagtaat ga                                                           12


<210>  10
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Olignucleotide

<400>  10
catatgggat cc                                                           12


<210>  11
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  11
ctcgagggta agcctatccc taaccctctc ctcggtctcg attctacgca ccaccaccac       60

caccactaat ga                                                           72


<210>  12
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile 
1               5                   10                  15      


Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser 
            20                  25                  30          


Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met 
        35                  40                  45              


Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro 
    50                  55                  60                  


Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala 
65                  70                  75                  80  


Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys 
                85                  90                  95      


Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile 
            100                 105                 110         


Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro 
        115                 120                 125             


His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn 
    130                 135                 140                 


Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr 
145                 150                 155                 160 


Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro 
                165                 170                 175     


Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val 
            180                 185                 190         


Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu 
        195                 200                 205             


Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala 
    210                 215                 220                 


Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr 
225                 230                 235                 240 


Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys 
                245                 250                 255     


His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser 
            260                 265                 270         


Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser 
        275                 280                 285             


Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln 
    290                 295                 300                 


Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr 
305                 310                 315                 320 


Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His 
                325                 330                 335     


Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala 
            340                 345                 350         


Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile 
        355                 360                 365             


Lys Thr Lys Val Asn Lys His Ala Phe 
    370                 375         


<210>  13
<211>  1131
<212>  DNA
<213>  Homo sapiens

<400>  13
atgcccaaca gtgagcccgc atctctgctg gagctgttca acagcatcgc cacacaaggg       60

gagctcgtaa ggtccctcaa agcgggaaat gcgtcaaagg atgaaattga ttctgcagta      120

aagatgttgg tgtcattaaa aatgagctac aaagctgccg cgggggagga ttacaaggct      180

gactgtcctc cagggaaccc agcacctacc agtaatcatg gcccagatgc cacagaagct      240

gaagaggatt ttgtggaccc atggacagta cagacaagca gtgcaaaagg catagactac      300

gataagctca ttgttcggtt tggaagtagt aaaattgaca aagagctaat aaaccgaata      360

gagagagcca ccggccaaag accacaccac ttcctgcgca gaggcatctt cttctcacac      420

agagatatga atcaggttct tgatgcctat gaaaataaga agccatttta tctgtacacg      480

ggccggggcc cctcttctga agcaatgcat gtaggtcacc tcattccatt tattttcaca      540

aagtggctcc aggatgtatt taacgtgccc ttggtcatcc agatgacgga tgacgagaag      600

tatctgtgga aggacctgac cctggaccag gcctatagct atgctgtgga gaatgccaag      660

gacatcatcg cctgtggctt tgacatcaac aagactttca tattctctga cctggactac      720

atggggatga gctcaggttt ctacaaaaat gtggtgaaga ttcaaaagca tgttaccttc      780

aaccaagtga aaggcatttt cggcttcact gacagcgact gcattgggaa gatcagtttt      840

cctgccatcc aggctgctcc ctccttcagc aactcattcc cacagatctt ccgagacagg      900

acggatatcc agtgccttat cccatgtgcc attgaccagg atccttactt tagaatgaca      960

agggacgtcg cccccaggat cggctatcct aaaccagccc tgctgcactc caccttcttc     1020

ccagccctgc agggcgccca gaccaaaatg agtgccagcg accccaactc ctccatcttc     1080

ctcaccgaca cggccaagca gatcaaaacc aaggtcaata agcatgcgtt t              1131


<210>  14
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile 
1               5                   10                  15      


Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser 
            20                  25                  30          


Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met 
        35                  40                  45              


Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro 
    50                  55                  60                  


Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala 
65                  70                  75                  80  


Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys 
                85                  90                  95      


Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile 
            100                 105                 110         


Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro 
        115                 120                 125             


His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn 
    130                 135                 140                 


Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr 
145                 150                 155                 160 


Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro 
                165                 170                 175     


Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val 
            180                 185                 190         


Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu 
        195                 200                 205             


Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala 
    210                 215                 220                 


Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr 
225                 230                 235                 240 


Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys 
                245                 250                 255     


His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser 
            260                 265                 270         


Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser 
        275                 280                 285             


Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln 
    290                 295                 300                 


Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr 
305                 310                 315                 320 


Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His 
                325                 330                 335     


Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala 
            340                 345                 350         


Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys 
        355                 360                 365     


<210>  15
<211>  1098
<212>  DNA
<213>  Homo sapiens

<400>  15
atgcccaaca gtgagcccgc atctctgctg gagctgttca acagcatcgc cacacaaggg       60

gagctcgtaa ggtccctcaa agcgggaaat gcgtcaaagg atgaaattga ttctgcagta      120

aagatgttgg tgtcattaaa aatgagctac aaagctgccg cgggggagga ttacaaggct      180

gactgtcctc cagggaaccc agcacctacc agtaatcatg gcccagatgc cacagaagct      240

gaagaggatt ttgtggaccc atggacagta cagacaagca gtgcaaaagg catagactac      300

gataagctca ttgttcggtt tggaagtagt aaaattgaca aagagctaat aaaccgaata      360

gagagagcca ccggccaaag accacaccac ttcctgcgca gaggcatctt cttctcacac      420

agagatatga atcaggttct tgatgcctat gaaaataaga agccatttta tctgtacacg      480

ggccggggcc cctcttctga agcaatgcat gtaggtcacc tcattccatt tattttcaca      540

aagtggctcc aggatgtatt taacgtgccc ttggtcatcc agatgacgga tgacgagaag      600

tatctgtgga aggacctgac cctggaccag gcctatagct atgctgtgga gaatgccaag      660

gacatcatcg cctgtggctt tgacatcaac aagactttca tattctctga cctggactac      720

atggggatga gctcaggttt ctacaaaaat gtggtgaaga ttcaaaagca tgttaccttc      780

aaccaagtga aaggcatttt cggcttcact gacagcgact gcattgggaa gatcagtttt      840

cctgccatcc aggctgctcc ctccttcagc aactcattcc cacagatctt ccgagacagg      900

acggatatcc agtgccttat cccatgtgcc attgaccagg atccttactt tagaatgaca      960

agggacgtcg cccccaggat cggctatcct aaaccagccc tgctgcactc caccttcttc     1020

ccagccctgc agggcgccca gaccaaaatg agtgccagcg accccaactc ctccatcttc     1080

ctcaccgaca cggccaag                                                   1098


<210>  16
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile 
1               5                   10                  15      


Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser 
            20                  25                  30          


Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met 
        35                  40                  45              


Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro 
    50                  55                  60                  


Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala 
65                  70                  75                  80  


Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys 
                85                  90                  95      


Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile 
            100                 105                 110         


Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro 
        115                 120                 125             


His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn 
    130                 135                 140                 


Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr 
145                 150                 155                 160 


Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro 
                165                 170                 175     


Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val 
            180                 185                 190         


Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu 
        195                 200                 205             


Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala 
    210                 215                 220                 


Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr 
225                 230                 235                 240 


Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys 
                245                 250                 255     


<210>  17
<211>  768
<212>  DNA
<213>  Homo sapiens

<400>  17
atgcccaaca gtgagcccgc atctctgctg gagctgttca acagcatcgc cacacaaggg       60

gagctcgtaa ggtccctcaa agcgggaaat gcgtcaaagg atgaaattga ttctgcagta      120

aagatgttgg tgtcattaaa aatgagctac aaagctgccg cgggggagga ttacaaggct      180

gactgtcctc cagggaaccc agcacctacc agtaatcatg gcccagatgc cacagaagct      240

gaagaggatt ttgtggaccc atggacagta cagacaagca gtgcaaaagg catagactac      300

gataagctca ttgttcggtt tggaagtagt aaaattgaca aagagctaat aaaccgaata      360

gagagagcca ccggccaaag accacaccac ttcctgcgca gaggcatctt cttctcacac      420

agagatatga atcaggttct tgatgcctat gaaaataaga agccatttta tctgtacacg      480

ggccggggcc cctcttctga agcaatgcat gtaggtcacc tcattccatt tattttcaca      540

aagtggctcc aggatgtatt taacgtgccc ttggtcatcc agatgacgga tgacgagaag      600

tatctgtgga aggacctgac cctggaccag gcctatagct atgctgtgga gaatgccaag      660

gacatcatcg cctgtggctt tgacatcaac aagactttca tattctctga cctggactac      720

atggggatga gctcaggttt ctacaaaaat gtggtgaaga ttcaaaag                   768


<210>  18
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  18

Ala Gly Cys Pro Pro Gly Asn Pro Thr Ala Gly Arg 
1               5                   10          


<210>  19
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  19

Asn Cys Asp Ser Asp Ala Thr Lys 
1               5               


<210>  20
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  20

Ala Ser Glu Asp Phe Val Asp Pro Trp Thr Val Arg 
1               5                   10          


<210>  21
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  21

Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Gln Phe 
1               5                   10                  15      


Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala 
            20                  25                  30          


Thr Gly Gln Arg Pro His Arg Phe Leu Arg Arg Gly Ile Phe Phe Ser 
        35                  40                  45              


His Arg Asp Met Asn Gln Ile Leu Asp Ala Tyr Glu Asn Lys Lys Pro 
    50                  55                  60                  


Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Leu 
65                  70                  75                  80  


Gly His Leu Val Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe 
                85                  90                  95      


Asn Val Pro Leu Val Ile Gln Met Ser Asp Asp Glu Lys Tyr Leu Trp 
            100                 105                 110         


Lys 
    


<210>  22
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  22

Asp Leu Thr Leu Glu Gln Ala Tyr Ser Tyr Thr Val Glu Asn Ala Lys 
1               5                   10                  15      


<210>  23
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys 
1               5                   10      


<210>  24
<211>  46
<212>  PRT
<213>  Mus musculus

<400>  24

Thr Phe Ile Phe Ser Asp Leu Glu Tyr Met Gly Gln Ser Pro Gly Phe 
1               5                   10                  15      


Tyr Arg Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val 
            20                  25                  30          


Lys Gly Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys 
        35                  40                  45      


<210>  25
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  25

Ile Ser Phe Pro Ala Val Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe 
1               5                   10                  15      


Pro Lys 
        


<210>  26
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  26

Ala Gly Cys Pro Pro Gly Asn Pro Thr Ala Gly Arg Asn Cys Asp Ser 
1               5                   10                  15      


Asp Ala Thr Lys Ala Ser Glu Asp Phe Val Asp Pro Trp Thr Val Arg 
            20                  25                  30          


Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Gln Phe 
        35                  40                  45              


Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala 
    50                  55                  60                  


Thr Gly Gln Arg Pro His Arg Phe Leu Arg Arg Gly Ile Phe Phe Ser 
65                  70                  75                  80  


His Arg Asp Met Asn Gln Ile Leu Asp Ala Tyr Glu Asn Lys Lys Pro 
                85                  90                  95      


Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Leu 
            100                 105                 110         


Gly His Leu Val Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe 
        115                 120                 125             


Asn Val Pro Leu Val Ile Gln Met Ser Asp Asp Glu Lys Tyr Leu Trp 
    130                 135                 140                 


Lys Asp Leu Thr Leu Glu Gln Ala Tyr Ser Tyr Thr Val Glu Asn Ala 
145                 150                 155                 160 


Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe 
                165                 170                 175     


Ser Asp Leu Glu Tyr Met Gly Gln Ser Pro Gly Phe Tyr Arg Asn Val 
            180                 185                 190         


Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe 
        195                 200                 205             


Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Val 
    210                 215                 220                 


Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Lys 
225                 230                 235     


<210>  27
<211>  24
<212>  PRT
<213>  Mus musculus

<400>  27

Pro Ser Gly Glu Ser Cys Thr Ser Pro Leu Glu Leu Phe Asn Ser Ile 
1               5                   10                  15      


Ala Thr Gln Gly Glu Leu Val Arg 
            20                  


<210>  28
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  28

Ser Leu Lys 
1           


<210>  29
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  29

Ala Gly Asn Ala Pro Lys Asp Glu Ile Asp Ser Ala Val Lys 
1               5                   10                  


<210>  30
<211>  38
<212>  PRT
<213>  Mus musculus

<400>  30

Met Leu Leu Ser Leu Lys Met Ser Tyr Lys Ala Ala Met Gly Glu Glu 
1               5                   10                  15      


Tyr Lys Ala Gly Cys Pro Pro Gly Asn Pro Thr Ala Gly Arg Asn Cys 
            20                  25                  30          


Asp Ser Asp Ala Thr Lys 
        35              


<210>  31
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  31

Ala Ser Glu Asp Phe Val Asp Pro Trp Thr Val Arg 
1               5                   10          


<210>  32
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  32

Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Gln Phe 
1               5                   10                  15      


Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala 
            20                  25                  30          


Thr Gly Gln Arg Pro His Arg Phe Leu Arg Arg Gly Ile Phe Phe Ser 
        35                  40                  45              


His Arg Asp Met Asn Gln Ile Leu Asp Ala Tyr Glu Asn Lys Lys Pro 
    50                  55                  60                  


Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Leu 
65                  70                  75                  80  


Gly His Leu Val Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe 
                85                  90                  95      


Asn Val Pro Leu Val Ile Gln Met Ser Asp Asp Glu Lys Tyr Leu Trp 
            100                 105                 110         


Lys 
    


<210>  33
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  33

Asp Leu Thr Leu Glu Gln Ala Tyr Ser Tyr Thr Val Glu Asn Ala Lys 
1               5                   10                  15      


Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys 
            20                  25          


<210>  34
<211>  33
<212>  PRT
<213>  Mus musculus

<400>  34

Thr Phe Ile Phe Ser Asp Leu Glu Tyr Met Gly Gln Ser Pro Gly Phe 
1               5                   10                  15      


Tyr Arg Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val 
            20                  25                  30          


Lys 
    


<210>  35
<211>  31
<212>  PRT
<213>  Mus musculus

<400>  35

Gly Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe 
1               5                   10                  15      


Pro Ala Val Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Lys 
            20                  25                  30      


<210>  36
<211>  54
<212>  PRT
<213>  Mus musculus

<400>  36

Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile 
1               5                   10                  15      


Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile 
            20                  25                  30          


Gly His Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu 
        35                  40                  45              


Gln Gly Ala Gln Thr Lys 
    50                  


<210>  37
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  37

Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala 
1               5                   10                  15      


Lys 
    


<210>  38
<211>  366
<212>  PRT
<213>  Mus musculus

<400>  38

Pro Ser Gly Glu Ser Cys Thr Ser Pro Leu Glu Leu Phe Asn Ser Ile 
1               5                   10                  15      


Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Pro 
            20                  25                  30          


Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Leu Ser Leu Lys Met 
        35                  40                  45              


Ser Tyr Lys Ala Ala Met Gly Glu Glu Tyr Lys Ala Gly Cys Pro Pro 
    50                  55                  60                  


Gly Asn Pro Thr Ala Gly Arg Asn Cys Asp Ser Asp Ala Thr Lys Ala 
65                  70                  75                  80  


Ser Glu Asp Phe Val Asp Pro Trp Thr Val Arg Thr Ser Ser Ala Lys 
                85                  90                  95      


Gly Ile Asp Tyr Asp Lys Leu Ile Val Gln Phe Gly Ser Ser Lys Ile 
            100                 105                 110         


Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro 
        115                 120                 125             


His Arg Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn 
    130                 135                 140                 


Gln Ile Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr 
145                 150                 155                 160 


Gly Arg Gly Pro Ser Ser Glu Ala Met His Leu Gly His Leu Val Pro 
                165                 170                 175     


Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val 
            180                 185                 190         


Ile Gln Met Ser Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu 
        195                 200                 205             


Glu Gln Ala Tyr Ser Tyr Thr Val Glu Asn Ala Lys Asp Ile Ile Ala 
    210                 215                 220                 


Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Glu Tyr 
225                 230                 235                 240 


Met Gly Gln Ser Pro Gly Phe Tyr Arg Asn Val Val Lys Ile Gln Lys 
                245                 250                 255     


His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser 
            260                 265                 270         


Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Val Gln Ala Ala Pro Ser 
        275                 280                 285             


Phe Ser Asn Ser Phe Pro Lys Ile Phe Arg Asp Arg Thr Asp Ile Gln 
    290                 295                 300                 


Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr 
305                 310                 315                 320 


Arg Asp Val Ala Pro Arg Ile Gly His Pro Lys Pro Ala Leu Leu His 
                325                 330                 335     


Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala 
            340                 345                 350         


Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys 
        355                 360                 365     


<210>  39
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  39

Ala Gly Asn Ala Pro Lys Asp Glu Ile Asp Ser Ala Val Lys 
1               5                   10                  


<210>  40
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  40

Met Leu Leu Ser Leu Lys Met Ser Tyr Lys Ala Ala Met Gly Glu Glu 
1               5                   10                  15      


Tyr Lys 
        


<210>  41
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  41

Ala Gly Cys Pro Pro Gly Asn Pro Thr Ala Gly Arg 
1               5                   10          


<210>  42
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  42

Asn Cys Asp Ser Asp Ala Thr Lys 
1               5               


<210>  43
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  43

Ala Ser Glu Asp Phe Val Asp Pro Trp Thr Val Arg 
1               5                   10          


<210>  44
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  44

Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Gln Phe 
1               5                   10                  15      


Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala 
            20                  25                  30          


Thr Gly Gln Arg Pro His Arg Phe Leu Arg Arg Gly Ile Phe Phe Ser 
        35                  40                  45              


His Arg Asp Met Asn Gln Ile Leu Asp Ala Tyr Glu Asn Lys Lys Pro 
    50                  55                  60                  


Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Leu 
65                  70                  75                  80  


Gly His Leu Val Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe 
                85                  90                  95      


Asn Val Pro Leu Val Ile Gln Met Ser Asp Asp Glu Lys Tyr Leu Trp 
            100                 105                 110         


Lys 
    


<210>  45
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  45

Asp Leu Thr Leu Glu Gln Ala Tyr Ser Tyr Thr Val Glu Asn Ala Lys 
1               5                   10                  15      


<210>  46
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  46

Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys 
1               5                   10      


<210>  47
<211>  222
<212>  PRT
<213>  Mus musculus

<400>  47

Ala Gly Asn Ala Pro Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu 
1               5                   10                  15      


Leu Ser Leu Lys Met Ser Tyr Lys Ala Ala Met Gly Glu Glu Tyr Lys 
            20                  25                  30          


Ala Gly Cys Pro Pro Gly Asn Pro Thr Ala Gly Arg Asn Cys Asp Ser 
        35                  40                  45              


Asp Ala Thr Lys Ala Ser Glu Asp Phe Val Asp Pro Trp Thr Val Arg 
    50                  55                  60                  


Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Gln Phe 
65                  70                  75                  80  


Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala 
                85                  90                  95      


Thr Gly Gln Arg Pro His Arg Phe Leu Arg Arg Gly Ile Phe Phe Ser 
            100                 105                 110         


His Arg Asp Met Asn Gln Ile Leu Asp Ala Tyr Glu Asn Lys Lys Pro 
        115                 120                 125             


Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Leu 
    130                 135                 140                 


Gly His Leu Val Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe 
145                 150                 155                 160 


Asn Val Pro Leu Val Ile Gln Met Ser Asp Asp Glu Lys Tyr Leu Trp 
                165                 170                 175     


Lys Asp Leu Thr Leu Glu Gln Ala Tyr Ser Tyr Thr Val Glu Asn Ala 
            180                 185                 190         


Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe 
        195                 200                 205             


Ser Asp Leu Glu Tyr Met Gly Gln Ser Pro Gly Phe Tyr Arg 
    210                 215                 220         


<210>  48
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile 
1               5                   10                  15      


Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser 
            20                  25                  30          


Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met 
        35                  40                  45              


Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro 
    50                  55                  60                  


Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala 
65                  70                  75                  80  


Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys 
                85                  90                  95      


Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile 
            100                 105                 110         


Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro 
        115                 120                 125             


His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn 
    130                 135                 140                 


Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr 
145                 150                 155                 160 


Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro 
                165                 170                 175     


Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val 
            180                 185                 190         


Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu 
        195                 200                 205             


Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala 
    210                 215                 220                 


Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr 
225                 230                 235                 240 


Met Gly Glu Asp Gln Phe Ser Cys His Pro Gly Cys Ser Leu Leu Gln 
                245                 250                 255     


Gln Leu Ile Pro Thr Asp Leu Pro Arg Gln Asp Gly Tyr Pro Val Pro 
            260                 265                 270         


Tyr Pro Met Cys His 
        275         


<210>  49
<211>  834
<212>  DNA
<213>  Homo sapiens

<400>  49
atgcccaaca gtgagcccgc atctctgctg gagctgttca acagcatcgc cacacaaggg       60

gagctcgtaa ggtccctcaa agcgggaaat gcgtcaaagg atgaaattga ttctgcagta      120

aagatgttgg tgtcattaaa aatgagctac aaagctgccg cgggggagga ttacaaggct      180

gactgtcctc cagggaaccc agcacctacc agtaatcatg gcccagatgc cacagaagct      240

gaagaggatt ttgtggaccc atggacagta cagacaagca gtgcaaaagg catagactac      300

gataagctca ttgttcggtt tggaagtagt aaaattgaca aagagctaat aaaccgaata      360

gagagagcca ccggccaaag accacaccac ttcctgcgca gaggcatctt cttctcacac      420

agagatatga atcaggttct tgatgcctat gaaaataaga agccatttta tctgtacacg      480

ggccggggcc cctcttctga agcaatgcat gtaggtcacc tcattccatt tattttcaca      540

aagtggctcc aggatgtatt taacgtgccc ttggtcatcc agatgacgga tgacgagaag      600

tatctgtgga aggacctgac cctggaccag gcctatagct atgctgtgga gaatgccaag      660

gacatcatcg cctgtggctt tgacatcaac aagactttca tattctctga cctggactac      720

atgggggaag atcagttttc ctgccatcca ggctgctccc tccttcagca actcattccc      780

acagatcttc cgagacagga cggatatcca gtgccttatc ccatgtgcca ttga            834


<210>  50
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile 
1               5                   10                  15      


Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser 
            20                  25                  30          


Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met 
        35                  40                  45              


Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro 
    50                  55                  60                  


Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala 
65                  70                  75                  80  


Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys 
                85                  90                  95      


Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile 
            100                 105                 110         


Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro 
        115                 120                 125             


His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn 
    130                 135                 140                 


Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr 
145                 150                 155                 160 


Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro 
                165                 170                 175     


Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val 
            180                 185                 190         


Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu 
        195                 200                 205             


Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala 
    210                 215                 220                 


Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr 
225                 230                 235                 240 


Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys 
                245                 250                 255     


His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser 
            260                 265                 270         


Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser 
        275                 280                 285             


Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln 
    290                 295                 300                 


Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr 
305                 310                 315                 320 


Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His 
                325                 330                 335     


Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala 
            340                 345                 350         


Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile 
        355                 360                 365             


Lys Thr Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys 
    370                 375                 380                 


Lys Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala 
385                 390                 395                 400 


Arg Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro 
                405                 410                 415     


Arg Lys Leu Ser Phe Asp Phe Gln 
            420                 


<210>  51
<211>  1275
<212>  DNA
<213>  Homo sapiens

<400>  51
atgcccaaca gtgagcccgc atctctgctg gagctgttca acagcatcgc cacacaaggg       60

gagctcgtaa ggtccctcaa agcgggaaat gcgtcaaagg atgaaattga ttctgcagta      120

aagatgttgg tgtcattaaa aatgagctac aaagctgccg cgggggagga ttacaaggct      180

gactgtcctc cagggaaccc agcacctacc agtaatcatg gcccagatgc cacagaagct      240

gaagaggatt ttgtggaccc atggacagta cagacaagca gtgcaaaagg catagactac      300

gataagctca ttgttcggtt tggaagtagt aaaattgaca aagagctaat aaaccgaata      360

gagagagcca ccggccaaag accacaccac ttcctgcgca gaggcatctt cttctcacac      420

agagatatga atcaggttct tgatgcctat gaaaataaga agccatttta tctgtacacg      480

ggccggggcc cctcttctga agcaatgcat gtaggtcacc tcattccatt tattttcaca      540

aagtggctcc aggatgtatt taacgtgccc ttggtcatcc agatgacgga tgacgagaag      600

tatctgtgga aggacctgac cctggaccag gcctatagct atgctgtgga gaatgccaag      660

gacatcatcg cctgtggctt tgacatcaac aagactttca tattctctga cctggactac      720

atggggatga gctcaggttt ctacaaaaat gtggtgaaga ttcaaaagca tgttaccttc      780

aaccaagtga aaggcatttt cggcttcact gacagcgact gcattgggaa gatcagtttt      840

cctgccatcc aggctgctcc ctccttcagc aactcattcc cacagatctt ccgagacagg      900

acggatatcc agtgccttat cccatgtgcc attgaccagg atccttactt tagaatgaca      960

agggacgtcg cccccaggat cggctatcct aaaccagccc tgctgcactc caccttcttc     1020

ccagccctgc agggcgccca gaccaaaatg agtgccagcg accccaactc ctccatcttc     1080

ctcaccgaca cggccaagca gatcaaaacc aaggattaca ccagcggagc catgctcacc     1140

ggtgagctca agaaggcact catagaggtt ctgcagccct tgatcgcaga gcaccaggcc     1200

cggcgcaagg aggtcacgga tgagatagtg aaagagttca tgactccccg gaagctgtcc     1260

ttcgactttc agtag                                                      1275


<210>  52
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  52
tattctctga cctggactac atgggggaag atcagttttc ctgccatcca                  50


<210>  53
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  53

Phe Ser Asp Leu Asp Tyr Met Gly Glu Asp Gln Phe Ser Cys His Pro 
1               5                   10                  15      


<210>  54
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  54
cacggccaag cagatcaaaa ccaaggatta caccagcgga gccatgctca                  50


<210>  55
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  55

Thr Ala Lys Gln Ile Lys Thr Lys Asp Tyr Thr Ser Gly Ala Met Leu 
1               5                   10                  15      


<210>  56
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile 
1               5                   10                  15      


Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser 
            20                  25                  30          


Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met 
        35                  40                  45              


Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro 
    50                  55                  60                  


Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala 
65                  70                  75                  80  


Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys 
                85                  90                  95      


Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile 
            100                 105                 110         


Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro 
        115                 120                 125             


His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn 
    130                 135                 140                 


Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr 
145                 150                 155         


<210>  57
<211>  471
<212>  DNA
<213>  Homo sapiens

<400>  57
atgcccaaca gtgagcccgc atctctgctg gagctgttca acagcatcgc cacacaaggg       60

gagctcgtaa ggtccctcaa agcgggaaat gcgtcaaagg atgaaattga ttctgcagta      120

aagatgttgg tgtcattaaa aatgagctac aaagctgccg cgggggagga ttacaaggct      180

gactgtcctc cagggaaccc agcacctacc agtaatcatg gcccagatgc cacagaagct      240

gaagaggatt ttgtggaccc atggacagta cagacaagca gtgcaaaagg catagactac      300

gataagctca ttgttcggtt tggaagtagt aaaattgaca aagagctaat aaaccgaata      360

gagagagcca ccggccaaag accacaccac ttcctgcgca gaggcatctt cttctcacac      420

agagatatga atcaggttct tgatgcctat gaaaataaga agccatttta t               471


<210>  58
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with N-terminal 6xHis 
       affinity tag

<400>  58

Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu 
1               5                   10                  15      


Gly Leu Asp Ser Thr Gly Ser Pro Asn Ser Glu Pro Ala Ser Leu Leu 
            20                  25                  30          


Glu Leu Phe Asn Ser Ile Ala Thr Gln Gly Glu Leu Val Arg Ser Leu 
        35                  40                  45              


Lys Ala Gly Asn Ala Ser Lys Asp Glu Ile Asp Ser Ala Val Lys Met 
    50                  55                  60                  


Leu Val Ser Leu Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr 
65                  70                  75                  80  


Lys Ala Asp Cys Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly 
                85                  90                  95      


Pro Asp Ala Thr Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val 
            100                 105                 110         


Gln Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg 
        115                 120                 125             


Phe Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg 
    130                 135                 140                 


Ala Thr Gly Gln Arg Pro His His Phe Leu Arg Arg Gly Ile Phe Phe 
145                 150                 155                 160 


Ser His Arg Asp Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys 
                165                 170                 175     


Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His 
            180                 185                 190         


Val Gly His Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val 
        195                 200                 205             


Phe Asn Val Pro Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu 
    210                 215                 220                 


Trp Lys Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn 
225                 230                 235                 240 


Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile 
                245                 250                 255     


Phe Ser Asp Leu Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn 
            260                 265                 270         


Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile 
        275                 280                 285             


Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala 
    290                 295                 300                 


Ile Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg 
305                 310                 315                 320 


Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp 
                325                 330                 335     


Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro 
            340                 345                 350         


Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala 
        355                 360                 365             


Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr 
    370                 375                 380                 


Asp Thr Ala Lys Gln Ile Lys Thr Lys Val Asn Lys His Ala Phe Leu 
385                 390                 395                 400 


Glu 
    


<210>  59
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with C-terminal 6xHis 
       affinity tag

<400>  59

Met Gly Ser Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn 
1               5                   10                  15      


Ser Ile Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn 
            20                  25                  30          


Ala Ser Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu 
        35                  40                  45              


Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys 
    50                  55                  60                  


Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr 
65                  70                  75                  80  


Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser 
                85                  90                  95      


Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser 
            100                 105                 110         


Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln 
        115                 120                 125             


Arg Pro His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp 
    130                 135                 140                 


Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu 
145                 150                 155                 160 


Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu 
                165                 170                 175     


Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro 
            180                 185                 190         


Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu 
        195                 200                 205             


Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile 
    210                 215                 220                 


Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu 
225                 230                 235                 240 


Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile 
                245                 250                 255     


Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr 
            260                 265                 270         


Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala 
        275                 280                 285             


Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp 
    290                 295                 300                 


Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg 
305                 310                 315                 320 


Met Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu 
                325                 330                 335     


Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met 
            340                 345                 350         


Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys 
        355                 360                 365             


Gln Ile Lys Thr Lys Val Asn Lys His Ala Phe Leu Glu Gly Lys Pro 
    370                 375                 380                 


Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His 
385                 390                 395                 400 


His 
    


<210>  60
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with N-terminal 6xHis 
       affinity tag

<400>  60

Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu 
1               5                   10                  15      


Gly Leu Asp Ser Thr Gly Ser Pro Asn Ser Glu Pro Ala Ser Leu Leu 
            20                  25                  30          


Glu Leu Phe Asn Ser Ile Ala Thr Gln Gly Glu Leu Val Arg Ser Leu 
        35                  40                  45              


Lys Ala Gly Asn Ala Ser Lys Asp Glu Ile Asp Ser Ala Val Lys Met 
    50                  55                  60                  


Leu Val Ser Leu Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr 
65                  70                  75                  80  


Lys Ala Asp Cys Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly 
                85                  90                  95      


Pro Asp Ala Thr Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val 
            100                 105                 110         


Gln Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg 
        115                 120                 125             


Phe Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg 
    130                 135                 140                 


Ala Thr Gly Gln Arg Pro His His Phe Leu Arg Arg Gly Ile Phe Phe 
145                 150                 155                 160 


Ser His Arg Asp Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys 
                165                 170                 175     


Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His 
            180                 185                 190         


Val Gly His Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val 
        195                 200                 205             


Phe Asn Val Pro Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu 
    210                 215                 220                 


Trp Lys Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn 
225                 230                 235                 240 


Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile 
                245                 250                 255     


Phe Ser Asp Leu Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn 
            260                 265                 270         


Val Val Lys Ile Gln Lys Leu Glu 
        275                 280 


<210>  61
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with C-terminal 6xHis 
       affinity tag

<400>  61

Met Gly Ser Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn 
1               5                   10                  15      


Ser Ile Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn 
            20                  25                  30          


Ala Ser Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu 
        35                  40                  45              


Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys 
    50                  55                  60                  


Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr 
65                  70                  75                  80  


Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser 
                85                  90                  95      


Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser 
            100                 105                 110         


Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln 
        115                 120                 125             


Arg Pro His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp 
    130                 135                 140                 


Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu 
145                 150                 155                 160 


Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu 
                165                 170                 175     


Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro 
            180                 185                 190         


Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu 
        195                 200                 205             


Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile 
    210                 215                 220                 


Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu 
225                 230                 235                 240 


Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile 
                245                 250                 255     


Gln Lys Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp 
            260                 265                 270         


Ser Thr His His His His His His 
        275                 280 


<210>  62
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with N-terminal 6xHis 
       affinity tag

<400>  62

Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu 
1               5                   10                  15      


Gly Leu Asp Ser Thr Gly Ser Pro Asn Ser Glu Pro Ala Ser Leu Leu 
            20                  25                  30          


Glu Leu Phe Asn Ser Ile Ala Thr Gln Gly Glu Leu Val Arg Ser Leu 
        35                  40                  45              


Lys Ala Gly Asn Ala Ser Lys Asp Glu Ile Asp Ser Ala Val Lys Met 
    50                  55                  60                  


Leu Val Ser Leu Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr 
65                  70                  75                  80  


Lys Ala Asp Cys Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly 
                85                  90                  95      


Pro Asp Ala Thr Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val 
            100                 105                 110         


Gln Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg 
        115                 120                 125             


Phe Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg 
    130                 135                 140                 


Ala Thr Gly Gln Arg Pro His His Phe Leu Arg Arg Gly Ile Phe Phe 
145                 150                 155                 160 


Ser His Arg Asp Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys 
                165                 170                 175     


Pro Phe Tyr Leu Glu 
            180     


<210>  63
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with C-terminal 6xHis 
       affinity tag

<400>  63

Met Gly Ser Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn 
1               5                   10                  15      


Ser Ile Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn 
            20                  25                  30          


Ala Ser Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu 
        35                  40                  45              


Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys 
    50                  55                  60                  


Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr 
65                  70                  75                  80  


Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser 
                85                  90                  95      


Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser 
            100                 105                 110         


Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln 
        115                 120                 125             


Arg Pro His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp 
    130                 135                 140                 


Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu 
145                 150                 155                 160 


Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His 
                165                 170                 175     


His His His His His 
            180     


<210>  64
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with N-terminal 6xHis 
       affinity tag

<400>  64

Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu 
1               5                   10                  15      


Gly Leu Asp Ser Thr Gly Ser Pro Asn Ser Glu Pro Ala Ser Leu Leu 
            20                  25                  30          


Glu Leu Phe Asn Ser Ile Ala Thr Gln Gly Glu Leu Val Arg Ser Leu 
        35                  40                  45              


Lys Ala Gly Asn Ala Ser Lys Asp Glu Ile Asp Ser Ala Val Lys Met 
    50                  55                  60                  


Leu Val Ser Leu Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr 
65                  70                  75                  80  


Lys Ala Asp Cys Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly 
                85                  90                  95      


Pro Asp Ala Thr Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val 
            100                 105                 110         


Gln Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg 
        115                 120                 125             


Phe Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg 
    130                 135                 140                 


Ala Thr Gly Gln Arg Pro His His Phe Leu Arg Arg Gly Ile Phe Phe 
145                 150                 155                 160 


Ser His Arg Asp Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys 
                165                 170                 175     


Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His 
            180                 185                 190         


Val Gly His Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val 
        195                 200                 205             


Phe Asn Val Pro Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu 
    210                 215                 220                 


Trp Lys Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn 
225                 230                 235                 240 


Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile 
                245                 250                 255     


Phe Ser Asp Leu Asp Tyr Met Gly Glu Asp Gln Phe Ser Cys His Pro 
            260                 265                 270         


Gly Cys Ser Leu Leu Gln Gln Leu Ile Pro Thr Asp Leu Pro Arg Gln 
        275                 280                 285             


Asp Gly Tyr Pro Val Pro Tyr Pro Met Cys His Leu Glu 
    290                 295                 300     


<210>  65
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with C-terminal 6xHis 
       affinity tag

<400>  65

Met Gly Ser Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn 
1               5                   10                  15      


Ser Ile Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn 
            20                  25                  30          


Ala Ser Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu 
        35                  40                  45              


Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys 
    50                  55                  60                  


Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr 
65                  70                  75                  80  


Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser 
                85                  90                  95      


Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser 
            100                 105                 110         


Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln 
        115                 120                 125             


Arg Pro His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp 
    130                 135                 140                 


Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu 
145                 150                 155                 160 


Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu 
                165                 170                 175     


Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro 
            180                 185                 190         


Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu 
        195                 200                 205             


Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile 
    210                 215                 220                 


Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu 
225                 230                 235                 240 


Asp Tyr Met Gly Glu Asp Gln Phe Ser Cys His Pro Gly Cys Ser Leu 
                245                 250                 255     


Leu Gln Gln Leu Ile Pro Thr Asp Leu Pro Arg Gln Asp Gly Tyr Pro 
            260                 265                 270         


Val Pro Tyr Pro Met Cys His Leu Glu Gly Lys Pro Ile Pro Asn Pro 
        275                 280                 285             


Leu Leu Gly Leu Asp Ser Thr His His His His His His 
    290                 295                 300     


<210>  66
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with N-terminal 6xHis 
       affinity tag

<400>  66

Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu 
1               5                   10                  15      


Gly Leu Asp Ser Thr Gly Ser Pro Asn Ser Glu Pro Ala Ser Leu Leu 
            20                  25                  30          


Glu Leu Phe Asn Ser Ile Ala Thr Gln Gly Glu Leu Val Arg Ser Leu 
        35                  40                  45              


Lys Ala Gly Asn Ala Ser Lys Asp Glu Ile Asp Ser Ala Val Lys Met 
    50                  55                  60                  


Leu Val Ser Leu Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr 
65                  70                  75                  80  


Lys Ala Asp Cys Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly 
                85                  90                  95      


Pro Asp Ala Thr Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val 
            100                 105                 110         


Gln Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg 
        115                 120                 125             


Phe Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg 
    130                 135                 140                 


Ala Thr Gly Gln Arg Pro His His Phe Leu Arg Arg Gly Ile Phe Phe 
145                 150                 155                 160 


Ser His Arg Asp Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys 
                165                 170                 175     


Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His 
            180                 185                 190         


Val Gly His Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val 
        195                 200                 205             


Phe Asn Val Pro Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu 
    210                 215                 220                 


Trp Lys Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn 
225                 230                 235                 240 


Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile 
                245                 250                 255     


Phe Ser Asp Leu Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn 
            260                 265                 270         


Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile 
        275                 280                 285             


Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala 
    290                 295                 300                 


Ile Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg 
305                 310                 315                 320 


Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp 
                325                 330                 335     


Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro 
            340                 345                 350         


Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala 
        355                 360                 365             


Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr 
    370                 375                 380                 


Asp Thr Ala Lys Gln Ile Lys Thr Lys Asp Tyr Thr Ser Gly Ala Met 
385                 390                 395                 400 


Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu Val Leu Gln Pro Leu 
                405                 410                 415     


Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val Thr Asp Glu Ile Val 
            420                 425                 430         


Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln Leu Glu 
        435                 440                 445             


<210>  67
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with C-terminal 6xHis 
       affinity tag

<400>  67

Met Gly Ser Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn 
1               5                   10                  15      


Ser Ile Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn 
            20                  25                  30          


Ala Ser Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu 
        35                  40                  45              


Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys 
    50                  55                  60                  


Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr 
65                  70                  75                  80  


Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser 
                85                  90                  95      


Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser 
            100                 105                 110         


Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln 
        115                 120                 125             


Arg Pro His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp 
    130                 135                 140                 


Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu 
145                 150                 155                 160 


Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu 
                165                 170                 175     


Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro 
            180                 185                 190         


Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu 
        195                 200                 205             


Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile 
    210                 215                 220                 


Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu 
225                 230                 235                 240 


Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile 
                245                 250                 255     


Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr 
            260                 265                 270         


Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala 
        275                 280                 285             


Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp 
    290                 295                 300                 


Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg 
305                 310                 315                 320 


Met Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu 
                325                 330                 335     


Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met 
            340                 345                 350         


Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys 
        355                 360                 365             


Gln Ile Lys Thr Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu 
    370                 375                 380                 


Leu Lys Lys Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His 
385                 390                 395                 400 


Gln Ala Arg Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met 
                405                 410                 415     


Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln Leu Glu Gly Lys Pro Ile 
            420                 425                 430         


Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His 
        435                 440                 445             


<210>  68
<211>  1140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized tryptophanyl tRNA synthetase polynucleotide

<400>  68
ggatccccta acagtgagcc ggccagcctg ctggagctgt ttaacagcat tgccacccaa       60

ggcgaactgg tgcgcagcct gaaggcaggc aatgccagca aggacgaaat cgacagcgcc      120

gtgaagatgc tggttagcct gaagatgagc tacaaagccg ccgccggcga agactataag      180

gcagattgtc ctccgggcaa cccggcccct accagtaatc atggtccgga cgccacagaa      240

gcagaagaag acttcgtgga cccgtggacc gtgcagacaa gcagcgccaa gggcatcgac      300

tatgacaagc tgatcgtgcg ctttggcagc agcaagatcg acaaggagtt aatcaaccgc      360

atcgagcgcg caaccggcca acgcccgcat cacttcctgc gtcgcggcat cttctttagc      420

caccgcgata tgaaccaggt gctggacgcc tacgagaaca aaaagccgtt ctacttatac      480

accggccgcg gtccgagcag cgaagcaatg cacgtgggtc atctgatccc gttcatcttc      540

accaagtggc tgcaggacgt gttcaacgtg ccgctggtga tccaaatgac cgacgacgag      600

aaatacctgt ggaaggacct gacactggac caggcctaca gctacgccgt ggaaaatgcc      660

aaggacatca tcgcctgcgg ctttgatatt aacaagacct tcattttcag cgacctggac      720

tacatgggca tgagcagcgg cttttataag aacgtggtga aaattcaaaa acacgtgacc      780

tttaaccaag tgaagggcat cttcggcttc accgacagcg actgcatcgg caagatcagc      840

ttccctgcca ttcaggccgc cccgagcttc agcaacagct tccctcagat cttccgtgac      900

cgcaccgaca tccagtgcct gatcccgtgc gccatcgacc aggacccgta cttccgcatg      960

acccgcgacg ttgcccctcg cattggctac ccgaagcctg ccctgctgca cagtacattc     1020

ttcccggccc tgcagggcgc ccagacaaag atgagcgcca gcgacccgaa cagcagcatc     1080

ttcctgaccg acaccgccaa gcagatcaag accaaggtga acaagcacgc cttcctcgag     1140


<210>  69
<211>  777
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized tryptophanyl tRNA synthetase polynucleotide

<400>  69
ggatccccta acagtgagcc ggccagcctg ctggagctgt ttaacagcat tgccacccaa       60

ggcgaactgg tgcgcagcct gaaggcaggc aatgccagca aggacgaaat cgacagcgcc      120

gtgaagatgc tggttagcct gaagatgagc tacaaagccg ccgccggcga agactataag      180

gcagattgtc ctccgggcaa cccggcccct accagtaatc atggtccgga cgccacagaa      240

gcagaagaag acttcgtgga cccgtggacc gtgcagacaa gcagcgccaa gggcatcgac      300

tatgacaagc tgatcgtgcg ctttggcagc agcaagatcg acaaggagtt aatcaaccgc      360

atcgagcgcg caaccggcca acgcccgcat cacttcctgc gtcgcggcat cttctttagc      420

caccgcgata tgaaccaggt gctggacgcc tacgagaaca aaaagccgtt ctacttatac      480

accggccgcg gtccgagcag cgaagcaatg cacgtgggtc atctgatccc gttcatcttc      540

accaagtggc tgcaggacgt gttcaacgtg ccgctggtga tccaaatgac cgacgacgag      600

aaatacctgt ggaaggacct gacactggac caggcctaca gctacgccgt ggaaaatgcc      660

aaggacatca tcgcctgcgg ctttgatatt aacaagacct tcattttcag cgacctggac      720

tacatgggca tgagcagcgg cttttataag aacgtggtga aaattcaaaa actcgag         777


<210>  70
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized tryptophanyl tRNA synthetase polynucleotide

<400>  70
ggatccccta acagtgagcc ggccagcctg ctggagctgt ttaacagcat tgccacccaa       60

ggcgaactgg tgcgcagcct gaaggcaggc aatgccagca aggacgaaat cgacagcgcc      120

gtgaagatgc tggttagcct gaagatgagc tacaaagccg ccgccggcga agactataag      180

gcagattgtc ctccgggcaa cccggcccct accagtaatc atggtccgga cgccacagaa      240

gcagaagaag acttcgtgga cccgtggacc gtgcagacaa gcagcgccaa gggcatcgac      300

tatgacaagc tgatcgtgcg ctttggcagc agcaagatcg acaaggagtt aatcaaccgc      360

atcgagcgcg caaccggcca acgcccgcat cacttcctgc gtcgcggcat cttctttagc      420

caccgcgata tgaaccaggt gctggacgcc tacgagaaca aaaagccgtt ctacctcgag      480


<210>  71
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized tryptophanyl tRNA synthetase polynucleotide

<400>  71
ggatccccta acagtgagcc ggccagcctg ctggagctgt ttaacagcat tgccacccaa       60

ggcgaactgg tgcgcagcct gaaggcaggc aatgccagca aggacgaaat cgacagcgcc      120

gtgaagatgc tggttagcct gaagatgagc tacaaagccg ccgccggcga agactataag      180

gcagattgtc ctccgggcaa cccggcccct accagtaatc atggtccgga cgccacagaa      240

gcagaagaag acttcgtgga cccgtggacc gtgcagacaa gcagcgccaa gggcatcgac      300

tatgacaagc tgatcgtgcg ctttggcagc agcaagatcg acaaggagtt aatcaaccgc      360

atcgagcgcg caaccggcca acgcccgcat cacttcctgc gtcgcggcat cttctttagc      420

caccgcgata tgaaccaggt gctggacgcc tacgagaaca aaaagccgtt ctacttatac      480

accggccgcg gtccgagcag cgaagcaatg cacgtgggtc atctgatccc gttcatcttc      540

accaagtggc tgcaggacgt gttcaacgtg ccgctggtga tccaaatgac cgacgacgag      600

aaatacctgt ggaaggacct gacactggac caggcctaca gctacgccgt ggaaaatgcc      660

aaggacatca tcgcctgcgg ctttgatatt aacaagacct tcattttcag cgacctggac      720

tacatgggcg aggaccagtt cagctgccac ccgggttgca gtctgctgca gcagctgatc      780

ccgacagacc tgccgcgtca ggacggttac ccggttccgt acccgatgtg ccacctcgag      840


<210>  72
<211>  1281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized tryptophanyl tRNA synthetase polynucleotide

<400>  72
ggatccccta acagtgagcc ggccagcctg ctggagctgt ttaacagcat tgccacccaa       60

ggcgaactgg tgcgcagcct gaaggcaggc aatgccagca aggacgaaat cgacagcgcc      120

gtgaagatgc tggttagcct gaagatgagc tacaaagccg ccgccggcga agactataag      180

gcagattgtc ctccgggcaa cccggcccct accagtaatc atggtccgga cgccacagaa      240

gcagaagaag acttcgtgga cccgtggacc gtgcagacaa gcagcgccaa gggcatcgac      300

tatgacaagc tgatcgtgcg ctttggcagc agcaagatcg acaaggagtt aatcaaccgc      360

atcgagcgcg caaccggcca acgcccgcat cacttcctgc gtcgcggcat cttctttagc      420

caccgcgata tgaaccaggt gctggacgcc tacgagaaca aaaagccgtt ctacttatac      480

accggccgcg gtccgagcag cgaagcaatg cacgtgggtc atctgatccc gttcatcttc      540

accaagtggc tgcaggacgt gttcaacgtg ccgctggtga tccaaatgac cgacgacgag      600

aaatacctgt ggaaggacct gacactggac caggcctaca gctacgccgt ggaaaatgcc      660

aaggacatca tcgcctgcgg ctttgatatt aacaagacct tcattttcag cgacctggac      720

tacatgggca tgagcagcgg cttttataag aacgtggtga aaattcaaaa acacgtgaca      780

ttcaaccagg tgaaaggtat cttcggcttt accgacagcg actgcatcgg caagattagt      840

tttccggcca tccaggcagc ccctagcttt agcaacagct ttccgcagat cttccgcgac      900

cgtaccgaca tccagtgtct gatcccttgc gccatcgacc aggacccgta tttccgcatg      960

acccgtgacg tggcaccgcg tattggctac ccgaagccgg ccctgttaca cagtaccttc     1020

tttccggccc tgcaaggcgc ccagaccaag atgagcgcca gcgacccgaa cagtagcatc     1080

ttcctgaccg acaccgccaa gcagatcaag accaaagact acacaagcgg cgcaatgctg     1140

acaggcgagc tgaagaaggc cctgatcgag gttctgcagc cgctgattgc cgaacaccag     1200

gcccgtcgta aggaagttac agacgaaatc gttaaggagt tcatgacccc gcgtaagctg     1260

agcttcgact ttcagctcga g                                               1281


<210>  73
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  73

Asn Lys Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu 
1               5                   10                  15      


Ala Met His Val Gly His Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu 
            20                  25                  30          


Gln Asp Val Phe Asn Val Pro Leu Val Ile Gln Met Thr Asp Asp Glu 
        35                  40                  45              


Lys Tyr Leu Trp Lys Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala 
    50                  55                  60                  


Val Glu Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys 
65                  70                  75                  80  


Thr Phe Ile Phe Ser Asp Leu Asp Tyr Met Gly Met Ser Ser Gly Phe 
                85                  90                  95      


Tyr Lys Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val 
            100                 105                 110         


Lys Gly Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser 
        115                 120                 125             


Phe Pro Ala Ile Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln 
    130                 135                 140                 


Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile 
145                 150                 155                 160 


Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile 
                165                 170                 175     


Gly Tyr Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu 
            180                 185                 190         


Gln Gly Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile 
        195                 200                 205             


Phe Leu Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys Val Asn Lys His 
    210                 215                 220                 


Ala Phe Ser Gly Gly Arg Asp Thr Ile Glu Glu His Arg Gln Phe Gly 
225                 230                 235                 240 


Gly Asn Cys Asp Val Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu 
                245                 250                 255     


Glu Asp Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly 
            260                 265                 270         


Ala Met Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu Val Leu Gln 
        275                 280                 285             


Pro Leu Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val Thr Asp Glu 
    290                 295                 300                 


Ile Val Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln 
305                 310                 315                 320 


<210>  74
<211>  963
<212>  DNA
<213>  Homo sapiens

<400>  74
aataagaagc cattttatct gtacacgggc cggggcccct cttctgaagc aatgcatgta       60

ggtcacctca ttccatttat tttcacaaag tggctccagg atgtatttaa cgtgcccttg      120

gtcatccaga tgacggatga cgagaagtat ctgtggaagg acctgaccct ggaccaggcc      180

tatagctatg ctgtggagaa tgccaaggac atcatcgcct gtggctttga catcaacaag      240

actttcatat tctctgacct ggactacatg gggatgagct caggtttcta caaaaatgtg      300

gtgaagattc aaaagcatgt taccttcaac caagtgaaag gcattttcgg cttcactgac      360

agcgactgca ttgggaagat cagttttcct gccatccagg ctgctccctc cttcagcaac      420

tcattcccac agatcttccg agacaggacg gatatccagt gccttatccc atgtgccatt      480

gaccaggatc cttactttag aatgacaagg gacgtcgccc ccaggatcgg ctatcctaaa      540

ccagccctgc tgcactccac cttcttccca gccctgcagg gcgcccagac caaaatgagt      600

gccagcgacc ccaactcctc catcttcctc accgacacgg ccaagcagat caaaaccaag      660

gtcaataagc atgcgttttc tggagggaga gacaccatcg aggagcacag gcagtttggg      720

ggcaactgtg atgtggacgt gtctttcatg tacctgacct tcttcctcga ggacgacgac      780

aagctcgagc agatcaggaa ggattacacc agcggagcca tgctcaccgg tgagctcaag      840

aaggcactca tagaggttct gcagcccttg atcgcagagc accaggcccg gcgcaaggag      900

gtcacggatg agatagtgaa agagttcatg actccccgga agctgtcctt cgactttcag      960

tag                                                                    963


<210>  75
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  75

Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser Phe Ser Asn 
1               5                   10                  15      


Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile 
            20                  25                  30          


Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val 
        35                  40                  45              


Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His Ser Thr Phe 
    50                  55                  60                  


Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala Ser Asp Pro 
65                  70                  75                  80  


Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys 
                85                  90                  95      


Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile Glu Glu His 
            100                 105                 110         


Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe Met Tyr Leu 
        115                 120                 125             


Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp 
    130                 135                 140                 


Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile 
145                 150                 155                 160 


Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg Arg Lys Glu 
                165                 170                 175     


Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg Lys Leu Ser 
            180                 185                 190         


Phe Asp Phe Gln 
        195     


<210>  76
<211>  591
<212>  DNA
<213>  Homo sapiens

<400>  76
gggaagatca gttttcctgc catccaggct gctccctcct tcagcaactc attcccacag       60

atcttccgag acaggacgga tatccagtgc cttatcccat gtgccattga ccaggatcct      120

tactttagaa tgacaaggga cgtcgccccc aggatcggct atcctaaacc agccctgctg      180

cactccacct tcttcccagc cctgcagggc gcccagacca aaatgagtgc cagcgacccc      240

aactcctcca tcttcctcac cgacacggcc aagcagatca aaaccaaggt caataagcat      300

gcgttttctg gagggagaga caccatcgag gagcacaggc agtttggggg caactgtgat      360

gtggacgtgt ctttcatgta cctgaccttc ttcctcgagg acgacgacaa gctcgagcag      420

atcaggaagg attacaccag cggagccatg ctcaccggtg agctcaagaa ggcactcata      480

gaggttctgc agcccttgat cgcagagcac caggcccggc gcaaggaggt cacggatgag      540

atagtgaaag agttcatgac tccccggaag ctgtccttcg actttcagta g               591


<210>  77
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  77

Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile 
1               5                   10                  15      


Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile 
            20                  25                  30          


Gly Tyr Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu 
        35                  40                  45              


Gln Gly Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile 
    50                  55                  60                  


Phe Leu Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys Val Asn Lys His 
65                  70                  75                  80  


Ala Phe Ser Gly Gly Arg Asp Thr Ile Glu Glu His Arg Gln Phe Gly 
                85                  90                  95      


Gly Asn Cys Asp Val Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu 
            100                 105                 110         


Glu Asp Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly 
        115                 120                 125             


Ala Met Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu Val Leu Gln 
    130                 135                 140                 


Pro Leu Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val Thr Asp Glu 
145                 150                 155                 160 


Ile Val Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln 
                165                 170                 175     


<210>  78
<211>  531
<212>  DNA
<213>  Homo sapiens

<400>  78
atcttccgag acaggacgga tatccagtgc cttatcccat gtgccattga ccaggatcct       60

tactttagaa tgacaaggga cgtcgccccc aggatcggct atcctaaacc agccctgctg      120

cactccacct tcttcccagc cctgcagggc gcccagacca aaatgagtgc cagcgacccc      180

aactcctcca tcttcctcac cgacacggcc aagcagatca aaaccaaggt caataagcat      240

gcgttttctg gagggagaga caccatcgag gagcacaggc agtttggggg caactgtgat      300

gtggacgtgt ctttcatgta cctgaccttc ttcctcgagg acgacgacaa gctcgagcag      360

atcaggaagg attacaccag cggagccatg ctcaccggtg agctcaagaa ggcactcata      420

gaggttctgc agcccttgat cgcagagcac caggcccggc gcaaggaggt cacggatgag      480

atagtgaaag agttcatgac tccccggaag ctgtccttcg actttcagta g               531


<210>  79
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  79

Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro Gly Asn Pro Ala Pro Thr 
1               5                   10                  15      


Ser Asn His Gly Pro Asp Ala Thr Glu Ala Glu Glu Asp Phe Val Asp 
            20                  25                  30          


Pro Trp Thr Val Gln Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys 
        35                  40                  45              


Leu Ile Val Arg Phe Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn 
    50                  55                  60                  


Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro His His Phe Leu Arg Arg 
65                  70                  75                  80  


Gly Ile Phe Phe Ser His Arg Asp Met Asn Gln Val Leu Asp Ala Tyr 
                85                  90                  95      


Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser 
            100                 105                 110         


Glu Ala Met His Val Gly His Leu Ile Pro Phe Ile Phe Thr Lys Trp 
        115                 120                 125             


Leu Gln Asp Val Phe Asn Val Pro Leu Val Ile Gln Met Thr Asp Asp 
    130                 135                 140                 


Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr 
145                 150                 155                 160 


Ala Val Glu Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn 
                165                 170                 175     


Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr Met Gly Met Ser Ser Gly 
            180                 185                 190         


Phe Tyr Lys Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln 
        195                 200                 205             


Val Lys Gly Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile 
    210                 215                 220                 


Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro 
225                 230                 235                 240 


Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala 
                245                 250                 255     


Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg 
            260                 265                 270         


Ile Gly Tyr Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala 
        275                 280                 285             


Leu Gln Gly Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser 
    290                 295                 300                 


Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys Val Asn Lys 
305                 310                 315                 320 


His Ala Phe Ser Gly Gly Arg Asp Thr Ile Glu Glu His Arg Gln Phe 
                325                 330                 335     


Gly Gly Asn Cys Asp Val Asp Val Ser Phe Met Tyr Leu Thr Phe Phe 
            340                 345                 350         


Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser 
        355                 360                 365             


Gly Ala Met Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu Val Leu 
    370                 375                 380                 


Gln Pro Leu Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val Thr Asp 
385                 390                 395                 400 


Glu Ile Val Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe Asp Phe 
                405                 410                 415     


Gln 
    


<210>  80
<211>  1254
<212>  DNA
<213>  Homo sapiens

<400>  80
ggggaggatt acaaggctga ctgtcctcca gggaacccag cacctaccag taatcatggc       60

ccagatgcca cagaagctga agaggatttt gtggacccat ggacagtaca gacaagcagt      120

gcaaaaggca tagactacga taagctcatt gttcggtttg gaagtagtaa aattgacaaa      180

gagctaataa accgaataga gagagccacc ggccaaagac cacaccactt cctgcgcaga      240

ggcatcttct tctcacacag agatatgaat caggttcttg atgcctatga aaataagaag      300

ccattttatc tgtacacggg ccggggcccc tcttctgaag caatgcatgt aggtcacctc      360

attccattta ttttcacaaa gtggctccag gatgtattta acgtgccctt ggtcatccag      420

atgacggatg acgagaagta tctgtggaag gacctgaccc tggaccaggc ctatagctat      480

gctgtggaga atgccaagga catcatcgcc tgtggctttg acatcaacaa gactttcata      540

ttctctgacc tggactacat ggggatgagc tcaggtttct acaaaaatgt ggtgaagatt      600

caaaagcatg ttaccttcaa ccaagtgaaa ggcattttcg gcttcactga cagcgactgc      660

attgggaaga tcagttttcc tgccatccag gctgctccct ccttcagcaa ctcattccca      720

cagatcttcc gagacaggac ggatatccag tgccttatcc catgtgccat tgaccaggat      780

ccttacttta gaatgacaag ggacgtcgcc cccaggatcg gctatcctaa accagccctg      840

ctgcactcca ccttcttccc agccctgcag ggcgcccaga ccaaaatgag tgccagcgac      900

cccaactcct ccatcttcct caccgacacg gccaagcaga tcaaaaccaa ggtcaataag      960

catgcgtttt ctggagggag agacaccatc gaggagcaca ggcagtttgg gggcaactgt     1020

gatgtggacg tgtctttcat gtacctgacc ttcttcctcg aggacgacga caagctcgag     1080

cagatcagga aggattacac cagcggagcc atgctcaccg gtgagctcaa gaaggcactc     1140

atagaggttc tgcagccctt gatcgcagag caccaggccc ggcgcaagga ggtcacggat     1200

gagatagtga aagagttcat gactccccgg aagctgtcct tcgactttca gtag           1254


<210>  81
<211>  1167
<212>  DNA
<213>  Homo sapiens

<400>  81
tttgtggacc catggacagt acagacaagc agtgcaaaag gcatagacta cgataagctc       60

attgttcggt ttggaagtag taaaattgac aaagagctaa taaaccgaat agagagagcc      120

accggccaaa gaccacacca cttcctgcgc agaggcatct tcttctcaca cagagatatg      180

aatcaggttc ttgatgccta tgaaaataag aagccatttt atctgtacac gggccggggc      240

ccctcttctg aagcaatgca tgtaggtcac ctcattccat ttattttcac aaagtggctc      300

caggatgtat ttaacgtgcc cttggtcatc cagatgacgg atgacgagaa gtatctgtgg      360

aaggacctga ccctggacca ggcctatagc tatgctgtgg agaatgccaa ggacatcatc      420

gcctgtggct ttgacatcaa caagactttc atattctctg acctggacta catggggatg      480

agctcaggtt tctacaaaaa tgtggtgaag attcaaaagc atgttacctt caaccaagtg      540

aaaggcattt tcggcttcac tgacagcgac tgcattggga agatcagttt tcctgccatc      600

caggctgctc cctccttcag caactcattc ccacagatct tccgagacag gacggatatc      660

cagtgcctta tcccatgtgc cattgaccag gatccttact ttagaatgac aagggacgtc      720

gcccccagga tcggctatcc taaaccagcc ctgctgcact ccaccttctt cccagccctg      780

cagggcgccc agaccaaaat gagtgccagc gaccccaact cctccatctt cctcaccgac      840

acggccaagc agatcaaaac caaggtcaat aagcatgcgt tttctggagg gagagacacc      900

atcgaggagc acaggcagtt tgggggcaac tgtgatgtgg acgtgtcttt catgtacctg      960

accttcttcc tcgaggacga cgacaagctc gagcagatca ggaaggatta caccagcgga     1020

gccatgctca ccggtgagct caagaaggca ctcatagagg ttctgcagcc cttgatcgca     1080

gagcaccagg cccggcgcaa ggaggtcacg gatgagatag tgaaagagtt catgactccc     1140

cggaagctgt ccttcgactt tcagtag                                         1167


<210>  82
<211>  28
<212>  PRT
<213>  Mus musculus

<400>  82

Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met 
1               5                   10                  15      


His Leu Gly His Leu Val Pro Phe Ile Phe Thr Lys 
            20                  25              


<210>  83
<211>  23
<212>  PRT
<213>  Mus musculus

<400>  83

Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val Ile Gln Met Ser Asp 
1               5                   10                  15      


Asp Glu Lys Tyr Leu Trp Lys 
            20              


<210>  84
<211>  27
<212>  PRT
<213>  Mus musculus

<400>  84

Asp Leu Thr Leu Glu Gln Ala Tyr Ser Tyr Thr Val Glu Asn Ala Lys 
1               5                   10                  15      


Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys 
            20                  25          


<210>  85
<211>  46
<212>  PRT
<213>  Mus musculus

<400>  85

Thr Phe Ile Phe Ser Asp Leu Glu Tyr Met Gly Gln Ser Pro Gly Phe 
1               5                   10                  15      


Tyr Arg Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val 
            20                  25                  30          


Lys Gly Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys 
        35                  40                  45      


<210>  86
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  86

Ile Ser Phe Pro Ala Val Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe 
1               5                   10                  15      


Pro Lys 
        


<210>  87
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  87

Ile Phe Arg Asp Arg 
1               5   


<210>  88
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  88

Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr 
1               5                   10                  15      


Phe Arg 
        


<210>  89
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  89

Met Thr Arg Asp Val Ala Pro Arg Ile Gly His Pro Lys Pro Ala 
1               5                   10                  15  


<210>  90
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  90

Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys 
1               5                   10                  15      


<210>  91
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  91

Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala 
1               5                   10                  15      


Lys 
    


<210>  92
<211>  66
<212>  PRT
<213>  Mus musculus

<400>  92

Gln Ile Lys Ser Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp 
1               5                   10                  15      


Thr Val Glu Glu His Arg Gln Phe Gly Gly Asn Cys Glu Val Asp Val 
            20                  25                  30          


Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Arg Leu Glu 
        35                  40                  45              


Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu 
    50                  55                  60                  


Lys Lys 
65      


<210>  93
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  93

Thr Leu Ile Asp Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg 
1               5                   10                  15      


<210>  94
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  94

Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys 
1               5                   10      


<210>  95
<211>  32
<212>  PRT
<213>  Mus musculus

<400>  95

Thr Phe Ile Phe Ser Leu Glu Tyr Met Gly Gln Ser Pro Gly Phe Tyr 
1               5                   10                  15      


Arg Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys 
            20                  25                  30          


<210>  96
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  96

Gly Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys 
1               5                   10              


<210>  97
<211>  54
<212>  PRT
<213>  Mus musculus

<400>  97

Ile Ser Phe Pro Ala Val Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe 
1               5                   10                  15      


Pro Lys Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys 
            20                  25                  30          


Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro 
        35                  40                  45              


Arg Ile Gly His Pro Lys 
    50                  


<210>  98
<211>  35
<212>  PRT
<213>  Mus musculus

<400>  98

Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln 
1               5                   10                  15      


Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp 
            20                  25                  30          


Thr Ala Lys 
        35  


<210>  99
<211>  51
<212>  PRT
<213>  Mus musculus

<400>  99

Gln Ile Lys Ser Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp 
1               5                   10                  15      


Thr Val Glu Glu His Arg Gln Phe Gly Gly Asn Cys Glu Val Asp Val 
            20                  25                  30          


Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Arg Leu Glu 
        35                  40                  45              


Gln Ile Arg 
    50      


<210>  100
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  100

Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys 
1               5                   10                  15  


<210>  101
<211>  295
<212>  PRT
<213>  Mus musculus

<400>  101

Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met 
1               5                   10                  15      


His Leu Gly His Leu Val Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp 
            20                  25                  30          


Val Phe Asn Val Pro Leu Val Ile Gln Met Ser Asp Asp Glu Lys Tyr 
        35                  40                  45              


Leu Trp Lys Asp Leu Thr Leu Glu Gln Ala Tyr Ser Tyr Thr Val Glu 
    50                  55                  60                  


Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe 
65                  70                  75                  80  


Ile Phe Ser Asp Leu Glu Tyr Met Gly Gln Ser Pro Gly Phe Tyr Arg 
                85                  90                  95      


Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly 
            100                 105                 110         


Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro 
        115                 120                 125             


Ala Val Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Lys Ile Phe 
    130                 135                 140                 


Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln 
145                 150                 155                 160 


Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly His 
                165                 170                 175     


Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly 
            180                 185                 190         


Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu 
        195                 200                 205             


Thr Asp Thr Ala Lys Gln Ile Lys Ser Lys Val Asn Lys His Ala Phe 
    210                 215                 220                 


Ser Gly Gly Arg Asp Thr Val Glu Glu His Arg Gln Phe Gly Gly Asn 
225                 230                 235                 240 


Cys Glu Val Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp 
                245                 250                 255     


Asp Asp Arg Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met 
            260                 265                 270         


Leu Thr Gly Glu Leu Lys Lys Thr Leu Ile Asp Val Leu Gln Pro Leu 
        275                 280                 285             


Ile Ala Glu His Gln Ala Arg 
    290                 295 


<210>  102
<211>  211
<212>  PRT
<213>  Mus musculus

<400>  102

Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser 
1               5                   10                  15      


Leu Glu Tyr Met Gly Gln Ser Pro Gly Phe Tyr Arg Asn Val Val Lys 
            20                  25                  30          


Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe 
        35                  40                  45              


Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Val Gln Ala 
    50                  55                  60                  


Ala Pro Ser Phe Ser Asn Ser Phe Pro Lys Ile Phe Arg Asp Arg Thr 
65                  70                  75                  80  


Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe 
                85                  90                  95      


Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly His Pro Lys Pro Ala 
            100                 105                 110         


Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys 
        115                 120                 125             


Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala 
    130                 135                 140                 


Lys Gln Ile Lys Ser Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg 
145                 150                 155                 160 


Asp Thr Val Glu Glu His Arg Gln Phe Gly Gly Asn Cys Glu Val Asp 
                165                 170                 175     


Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Arg Leu 
            180                 185                 190         


Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu 
        195                 200                 205             


Leu Lys Lys 
    210     


<210>  103
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  103

Ile Ser Phe Pro Ala Val Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe 
1               5                   10                  15      


Pro Lys 
        


<210>  104
<211>  54
<212>  PRT
<213>  Mus musculus

<400>  104

Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile 
1               5                   10                  15      


Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile 
            20                  25                  30          


Gly His Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu 
        35                  40                  45              


Gln Gly Ala Gln Thr Lys 
    50                  


<210>  105
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  105

Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala 
1               5                   10                  15      


Lys 
    


<210>  106
<211>  89
<212>  PRT
<213>  Mus musculus

<400>  106

Ile Ser Phe Pro Ala Val Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe 
1               5                   10                  15      


Pro Lys Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys 
            20                  25                  30          


Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro 
        35                  40                  45              


Arg Ile Gly His Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro 
    50                  55                  60                  


Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser 
65                  70                  75                  80  


Ser Ile Phe Leu Thr Asp Thr Ala Lys 
                85                  


<210>  107
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  107

Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr 
1               5                   10                  15      


Phe Arg 
        


<210>  108
<211>  114
<212>  PRT
<213>  Mus musculus

<400>  108

Met Thr Arg Asp Val Ala Pro Arg Ile Gly His Pro Lys Pro Ala Leu 
1               5                   10                  15      


Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met 
            20                  25                  30          


Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys 
        35                  40                  45              


Gln Ile Lys Ser Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp 
    50                  55                  60                  


Thr Val Glu Glu His Arg Gln Phe Gly Gly Asn Cys Glu Val Asp Val 
65                  70                  75                  80  


Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Arg Leu Glu 
                85                  90                  95      


Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu 
            100                 105                 110         


Lys Lys 
        


<210>  109
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  109

Thr Leu Ile Asp Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg 
1               5                   10                  15      


<210>  110
<211>  148
<212>  PRT
<213>  Mus musculus

<400>  110

Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr 
1               5                   10                  15      


Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly His Pro Lys Pro 
            20                  25                  30          


Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr 
        35                  40                  45              


Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr 
    50                  55                  60                  


Ala Lys Gln Ile Lys Ser Lys Val Asn Lys His Ala Phe Ser Gly Gly 
65                  70                  75                  80  


Arg Asp Thr Val Glu Glu His Arg Gln Phe Gly Gly Asn Cys Glu Val 
                85                  90                  95      


Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Arg 
            100                 105                 110         


Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly 
        115                 120                 125             


Glu Leu Lys Lys Thr Leu Ile Asp Val Leu Gln Pro Leu Ile Ala Glu 
    130                 135                 140                 


His Gln Ala Arg 
145             


<210>  111
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  111

Ala Ser Glu Asp Phe Val Asp Pro Trp Thr Val Arg 
1               5                   10          


<210>  112
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  112

Thr Ser Ser Ala Lys 
1               5   


<210>  113
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  113

Gly Ile Asp Tyr Asp Lys Leu Ile Val Gln Phe Gly Ser Ser Lys 
1               5                   10                  15  


<210>  114
<211>  93
<212>  PRT
<213>  Mus musculus

<400>  114

Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg 
1               5                   10                  15      


Pro His Arg Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met 
            20                  25                  30          


Asn Gln Ile Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr 
        35                  40                  45              


Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Leu Gly His Leu Val 
    50                  55                  60                  


Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu 
65                  70                  75                  80  


Val Ile Gln Met Ser Asp Asp Glu Lys Tyr Leu Trp Lys 
                85                  90              


<210>  115
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  115

Asp Leu Thr Leu Glu Gln Ala Tyr Ser Tyr Thr Val Glu Asn Ala Lys 
1               5                   10                  15      


<210>  116
<211>  80
<212>  PRT
<213>  Mus musculus

<400>  116

Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser 
1               5                   10                  15      


Asp Leu Glu Tyr Met Gly Gln Ser Pro Gly Phe Tyr Arg Asn Val Val 
            20                  25                  30          


Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly 
        35                  40                  45              


Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Val Gln 
    50                  55                  60                  


Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Lys Ile Phe Arg Asp Arg 
65                  70                  75                  80  


<210>  117
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  117

Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr 
1               5                   10                  15      


Phe Arg 
        


<210>  118
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  118

Met Thr Arg Asp Val Ala Pro Arg Ile Gly His Pro Lys Pro Ala 
1               5                   10                  15  


<210>  119
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  119

Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys 
1               5                   10                  15      


<210>  120
<211>  83
<212>  PRT
<213>  Mus musculus

<400>  120

Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala 
1               5                   10                  15      


Lys Gln Ile Lys Ser Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg 
            20                  25                  30          


Asp Thr Val Glu Glu His Arg Gln Phe Gly Gly Asn Cys Glu Val Asp 
        35                  40                  45              


Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Arg Leu 
    50                  55                  60                  


Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu 
65                  70                  75                  80  


Leu Lys Lys 
            


<210>  121
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  121

Thr Leu Ile Asp Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg 
1               5                   10                  15      


<210>  122
<211>  369
<212>  PRT
<213>  Mus musculus

<400>  122

Ala Ser Glu Asp Phe Val Asp Pro Trp Thr Val Arg Thr Ser Ser Ala 
1               5                   10                  15      


Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Gln Phe Gly Ser Ser Lys 
            20                  25                  30          


Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg 
        35                  40                  45              


Pro His Arg Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met 
    50                  55                  60                  


Asn Gln Ile Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr 
65                  70                  75                  80  


Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Leu Gly His Leu Val 
                85                  90                  95      


Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu 
            100                 105                 110         


Val Ile Gln Met Ser Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr 
        115                 120                 125             


Leu Glu Gln Ala Tyr Ser Tyr Thr Val Glu Asn Ala Lys Asp Ile Ile 
    130                 135                 140                 


Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Glu 
145                 150                 155                 160 


Tyr Met Gly Gln Ser Pro Gly Phe Tyr Arg Asn Val Val Lys Ile Gln 
                165                 170                 175     


Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp 
            180                 185                 190         


Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Val Gln Ala Ala Pro 
        195                 200                 205             


Ser Phe Ser Asn Ser Phe Pro Lys Ile Phe Arg Asp Arg Thr Asp Ile 
    210                 215                 220                 


Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met 
225                 230                 235                 240 


Thr Arg Asp Val Ala Pro Arg Ile Gly His Pro Lys Pro Ala Leu Leu 
                245                 250                 255     


His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser 
            260                 265                 270         


Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln 
        275                 280                 285             


Ile Lys Ser Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr 
    290                 295                 300                 


Val Glu Glu His Arg Gln Phe Gly Gly Asn Cys Glu Val Asp Val Ser 
305                 310                 315                 320 


Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Arg Leu Glu Gln 
                325                 330                 335     


Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys 
            340                 345                 350         


Lys Thr Leu Ile Asp Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala 
        355                 360                 365             


Arg 
    


<210>  123
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  123

Gly Ile Asp Tyr Asp Lys Leu Ile Val Gln Phe Gly Ser Ser Lys 
1               5                   10                  15  


<210>  124
<211>  30
<212>  PRT
<213>  Mus musculus

<400>  124

Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg 
1               5                   10                  15      


Pro His Arg Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg 
            20                  25                  30  


<210>  125
<211>  21
<212>  PRT
<213>  Mus musculus

<400>  125

Asp Met Asn Gln Ile Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr 
1               5                   10                  15      


Leu Tyr Thr Gly Arg 
            20      


<210>  126
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  126

Gly Pro Ser Ser Glu Ala Met His Leu 
1               5                   


<210>  127
<211>  29
<212>  PRT
<213>  Mus musculus

<400>  127

Gly His Leu Val Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe 
1               5                   10                  15      


Asn Val Pro Leu Val Ile Gln Met Ser Asp Asp Glu Lys 
            20                  25                  


<210>  128
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  128

Tyr Leu Trp Lys 
1               


<210>  129
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  129

Asp Leu Thr Leu Glu Gln Ala Tyr Ser Tyr Thr Val Glu Asn Ala Lys 
1               5                   10                  15      


<210>  130
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  130

Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys 
1               5                   10      


<210>  131
<211>  46
<212>  PRT
<213>  Mus musculus

<400>  131

Thr Phe Ile Phe Ser Asp Leu Glu Tyr Met Gly Gln Ser Pro Gly Phe 
1               5                   10                  15      


Tyr Arg Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val 
            20                  25                  30          


Lys Gly Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys 
        35                  40                  45      


<210>  132
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  132

Ile Ser Phe Pro Ala Val Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe 
1               5                   10                  15      


Pro Lys 
        


<210>  133
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  133

Ile Phe Arg 
1           


<210>  134
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  134

Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp 
1               5                   10                  15      


Pro Tyr Phe Arg 
            20  


<210>  135
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  135

Met Thr Arg Asp Val Ala Pro Arg Ile Gly His Pro Lys Pro Ala 
1               5                   10                  15  


<210>  136
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  136

Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys 
1               5                   10                  15      


<210>  137
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  137

Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala 
1               5                   10                  15      


Lys 
    


<210>  138
<211>  22
<212>  PRT
<213>  Mus musculus

<400>  138

Gln Ile Lys Ser Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp 
1               5                   10                  15      


Thr Val Glu Glu His Arg 
            20          


<210>  139
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  139

Gln Phe Gly Gly Asn Cys Glu Val Asp Val Ser Phe Met Tyr 
1               5                   10                  


<210>  140
<211>  30
<212>  PRT
<213>  Mus musculus

<400>  140

Leu Thr Phe Phe Leu Glu Asp Asp Asp Arg Leu Glu Gln Ile Arg Lys 
1               5                   10                  15      


Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys 
            20                  25                  30  


<210>  141
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  141

Thr Leu Ile Asp Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg 
1               5                   10                  15      


<210>  142
<211>  352
<212>  PRT
<213>  Mus musculus

<400>  142

Gly Ile Asp Tyr Asp Lys Leu Ile Val Gln Phe Gly Ser Ser Lys Ile 
1               5                   10                  15      


Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro 
            20                  25                  30          


His Arg Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn 
        35                  40                  45              


Gln Ile Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr 
    50                  55                  60                  


Gly Arg Gly Pro Ser Ser Glu Ala Met His Leu Gly His Leu Val Pro 
65                  70                  75                  80  


Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val 
                85                  90                  95      


Ile Gln Met Ser Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu 
            100                 105                 110         


Glu Gln Ala Tyr Ser Tyr Thr Val Glu Asn Ala Lys Asp Ile Ile Ala 
        115                 120                 125             


Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Glu Tyr 
    130                 135                 140                 


Met Gly Gln Ser Pro Gly Phe Tyr Arg Asn Val Val Lys Ile Gln Lys 
145                 150                 155                 160 


His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser 
                165                 170                 175     


Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Val Gln Ala Ala Pro Ser 
            180                 185                 190         


Phe Ser Asn Ser Phe Pro Lys Ile Phe Arg Asp Arg Thr Asp Ile Gln 
        195                 200                 205             


Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr 
    210                 215                 220                 


Arg Asp Val Ala Pro Arg Ile Gly His Pro Lys Pro Ala Leu Leu His 
225                 230                 235                 240 


Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala 
                245                 250                 255     


Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile 
            260                 265                 270         


Lys Ser Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Val 
        275                 280                 285             


Glu Glu His Arg Gln Phe Gly Gly Asn Cys Glu Val Asp Val Ser Phe 
    290                 295                 300                 


Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Arg Leu Glu Gln Ile 
305                 310                 315                 320 


Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys 
                325                 330                 335     


Thr Leu Ile Asp Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg 
            340                 345                 350         


<210>  143
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  143

Gly Ile Asp Tyr Asp Lys Leu Ile Val Gln Phe Gly Ser Ser Lys 
1               5                   10                  15  


<210>  144
<211>  30
<212>  PRT
<213>  Mus musculus

<400>  144

Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg 
1               5                   10                  15      


Pro His Arg Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg 
            20                  25                  30  


<210>  145
<211>  21
<212>  PRT
<213>  Mus musculus

<400>  145

Asp Met Asn Gln Ile Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr 
1               5                   10                  15      


Leu Tyr Thr Gly Arg 
            20      


<210>  146
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  146

Gly Pro Ser Ser Glu Ala Met His Leu 
1               5                   


<210>  147
<211>  29
<212>  PRT
<213>  Mus musculus

<400>  147

Gly His Leu Val Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe 
1               5                   10                  15      


Asn Val Pro Leu Val Ile Gln Met Ser Asp Asp Glu Lys 
            20                  25                  


<210>  148
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  148

Tyr Leu Trp Lys 
1               


<210>  149
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  149

Asp Leu Thr Leu Glu Gln Ala Tyr Ser Tyr Thr Val Glu Asn Ala Lys 
1               5                   10                  15      


<210>  150
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  150

Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys 
1               5                   10      


<210>  151
<211>  46
<212>  PRT
<213>  Mus musculus

<400>  151

Thr Phe Ile Phe Ser Asp Leu Glu Tyr Met Gly Gln Ser Pro Gly Phe 
1               5                   10                  15      


Tyr Arg Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val 
            20                  25                  30          


Lys Gly Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys 
        35                  40                  45      


<210>  152
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  152

Ile Ser Phe Pro Ala Val Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe 
1               5                   10                  15      


Pro Lys 
        


<210>  153
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  153

Ile Phe Arg 
1           


<210>  154
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  154

Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp 
1               5                   10                  15      


Pro Tyr Phe Arg 
            20  


<210>  155
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  155

Met Thr Arg Asp Val Ala Pro Arg Ile Gly His Pro Lys Pro Ala 
1               5                   10                  15  


<210>  156
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  156

Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys 
1               5                   10                  15      


<210>  157
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  157

Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala 
1               5                   10                  15      


Lys 
    


<210>  158
<211>  22
<212>  PRT
<213>  Mus musculus

<400>  158

Gln Ile Lys Ser Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp 
1               5                   10                  15      


Thr Val Glu Glu His Arg 
            20          


<210>  159
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  159

Gln Phe Gly Gly Asn Cys Glu Val Asp Val Ser Phe Met Tyr 
1               5                   10                  


<210>  160
<211>  30
<212>  PRT
<213>  Mus musculus

<400>  160

Leu Thr Phe Phe Leu Glu Asp Asp Asp Arg Leu Glu Gln Ile Arg Lys 
1               5                   10                  15      


Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys 
            20                  25                  30  


<210>  161
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  161

Thr Leu Ile Asp Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg 
1               5                   10                  15      


<210>  162
<211>  295
<212>  PRT
<213>  Mus musculus

<400>  162

Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met 
1               5                   10                  15      


His Leu Gly His Leu Val Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp 
            20                  25                  30          


Val Phe Asn Val Pro Leu Val Ile Gln Met Ser Asp Asp Glu Lys Tyr 
        35                  40                  45              


Leu Trp Lys Asp Leu Thr Leu Glu Gln Ala Tyr Ser Tyr Thr Val Glu 
    50                  55                  60                  


Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe 
65                  70                  75                  80  


Ile Phe Ser Asp Leu Glu Tyr Met Gly Gln Ser Pro Gly Phe Tyr Arg 
                85                  90                  95      


Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly 
            100                 105                 110         


Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro 
        115                 120                 125             


Ala Val Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Lys Ile Phe 
    130                 135                 140                 


Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln 
145                 150                 155                 160 


Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly His 
                165                 170                 175     


Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly 
            180                 185                 190         


Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu 
        195                 200                 205             


Thr Asp Thr Ala Lys Gln Ile Lys Ser Lys Val Asn Lys His Ala Phe 
    210                 215                 220                 


Ser Gly Gly Arg Asp Thr Val Glu Glu His Arg Gln Phe Gly Gly Asn 
225                 230                 235                 240 


Cys Glu Val Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp 
                245                 250                 255     


Asp Asp Arg Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met 
            260                 265                 270         


Leu Thr Gly Glu Leu Lys Lys Thr Leu Ile Asp Val Leu Gln Pro Leu 
        275                 280                 285             


Ile Ala Glu His Gln Ala Arg 
    290                 295 


<210>  163
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  163

Met Leu Val Ser Leu Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp 
1               5                   10                  15      


Tyr Lys Ala Asp Cys Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His 
            20                  25                  30          


Gly Pro Asp Ala Thr Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr 
        35                  40                  45              


Val Gln Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Gly 
    50                  55                  60                  


Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser Phe Ser Asn Ser 
65                  70                  75                  80  


Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro 
                85                  90                  95      


Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala 
            100                 105                 110         


Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe 
        115                 120                 125             


Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn 
    130                 135                 140                 


Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys Val 
145                 150                 155                 160 


Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile Glu Glu His Arg 
                165                 170                 175     


Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe Met Tyr Leu Thr 
            180                 185                 190         


Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp Tyr 
        195                 200                 205             


Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu 
    210                 215                 220                 


Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val 
225                 230                 235                 240 


Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe 
                245                 250                 255     


Asp Phe Gln 
            


<210>  164
<211>  780
<212>  DNA
<213>  Homo sapiens

<400>  164
atgttggtgt cattaaaaat gagctacaaa gctgccgcgg gggaggatta caaggctgac       60

tgtcctccag ggaacccagc acctaccagt aatcatggcc cagatgccac agaagctgaa      120

gaggattttg tggacccatg gacagtacag acaagcagtg caaaaggcat agactacgat      180

aagctcattg ggaagatcag ttttcctgcc atccaggctg ctccctcctt cagcaactca      240

ttcccacaga tcttccgaga caggacggat atccagtgcc ttatcccatg tgccattgac      300

caggatcctt actttagaat gacaagggac gtcgccccca ggatcggcta tcctaaacca      360

gccctgctgc actccacctt cttcccagcc ctgcagggcg cccagaccaa aatgagtgcc      420

agcgacccca actcctccat cttcctcacc gacacggcca agcagatcaa aaccaaggtc      480

aataagcatg cgttttctgg agggagagac accatcgagg agcacaggca gtttgggggc      540

aactgtgatg tggacgtgtc tttcatgtac ctgaccttct tcctcgagga cgacgacaag      600

ctcgagcaga tcaggaagga ttacaccagc ggagccatgc tcaccggtga gctcaagaag      660

gcactcatag aggttctgca gcccttgatc gcagagcacc aggcccggcg caaggaggtc      720

acggatgaga tagtgaaaga gttcatgact ccccggaagc tgtccttcga ctttcagtag      780


<210>  165
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Leu Trp Arg Met Pro Arg Thr Ser Ser Pro Val Ala Leu Thr Ser 
1               5                   10                  15      


Thr Arg Leu Ser Tyr Ser Leu Thr Trp Thr Thr Trp Gly Lys Ile Ser 
            20                  25                  30          


Phe Pro Ala Ile Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln 
        35                  40                  45              


Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile 
    50                  55                  60                  


Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile 
65                  70                  75                  80  


Gly Tyr Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu 
                85                  90                  95      


Gln Gly Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile 
            100                 105                 110         


Phe Leu Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys Val Asn Lys His 
        115                 120                 125             


Ala Phe Ser Gly Gly Arg Asp Thr Ile Glu Glu His Arg Gln Phe Gly 
    130                 135                 140                 


Gly Asn Cys Asp Val Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu 
145                 150                 155                 160 


Glu Asp Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly 
                165                 170                 175     


Ala Met Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu Val Leu Gln 
            180                 185                 190         


Pro Leu Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val Thr Asp Glu 
        195                 200                 205             


Ile Val Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln 
    210                 215                 220                 


<210>  166
<211>  675
<212>  DNA
<213>  Homo sapiens

<400>  166
atgctgtgga gaatgccaag gacatcatcg cctgtggctt tgacatcaac aagactttca       60

tattctctga cctggactac atgggggaag atcagttttc ctgccatcca ggctgctccc      120

tccttcagca actcattccc acagatcttc cgagacagga cggatatcca gtgccttatc      180

ccatgtgcca ttgaccagga tccttacttt agaatgacaa gggacgtcgc ccccaggatc      240

ggctatccta aaccagccct gctgcactcc accttcttcc cagccctgca gggcgcccag      300

accaaaatga gtgccagcga ccccaactcc tccatcttcc tcaccgacac ggccaagcag      360

atcaaaacca aggtcaataa gcatgcgttt tctggaggga gagacaccat cgaggagcac      420

aggcagtttg ggggcaactg tgatgtggac gtgtctttca tgtacctgac cttcttcctc      480

gaggacgacg acaagctcga gcagatcagg aaggattaca ccagcggagc catgctcacc      540

ggtgagctca agaaggcact catagaggtt ctgcagccct tgatcgcaga gcaccaggcc      600

cggcgcaagg aggtcacgga tgagatagtg aaagagttca tgactccccg gaagctgtcc      660

ttcgactttc agtag                                                       675


<210>  167
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile 
1               5                   10                  15      


Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser 
            20                  25                  30          


Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met 
        35                  40                  45              


Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro 
    50                  55                  60                  


Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala 
65                  70                  75                  80  


Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys 
                85                  90                  95      


Gly Ile Asp Tyr Asp Lys Leu Ile Gly Lys Ile Ser Phe Pro Ala Ile 
            100                 105                 110         


Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp 
        115                 120                 125             


Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro 
    130                 135                 140                 


Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys 
145                 150                 155                 160 


Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln 
                165                 170                 175     


Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp 
            180                 185                 190         


Thr Ala Lys Gln Ile Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly 
        195                 200                 205             


Gly Arg Asp Thr Ile Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp 
    210                 215                 220                 


Val Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp 
225                 230                 235                 240 


Lys Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr 
                245                 250                 255     


Gly Glu Leu Lys Lys Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala 
            260                 265                 270         


Glu His Gln Ala Arg Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu 
        275                 280                 285             


Phe Met Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln 
    290                 295                 300 


<210>  168
<211>  903
<212>  DNA
<213>  Homo sapiens

<400>  168
atgcccaaca gtgagcccgc atctctgctg gagctgttca acagcatcgc cacacaaggg       60

gagctcgtaa ggtccctcaa agcgggaaat gcgtcaaagg atgaaattga ttctgcagta      120

aagatgttgg tgtcattaaa aatgagctac aaagctgccg cgggggagga ttacaaggct      180

gactgtcctc cagggaaccc agcacctacc agtaatcatg gcccagatgc cacagaagct      240

gaagaggatt ttgtggaccc atggacagta cagacaagca gtgcaaaagg catagactac      300

gataagctca ttgggaagat cagttttcct gccatccagg ctgctccctc cttcagcaac      360

tcattcccac agatcttccg agacaggacg gatatccagt gccttatccc atgtgccatt      420

gaccaggatc cttactttag aatgacaagg gacgtcgccc ccaggatcgg ctatcctaaa      480

ccagccctgc tgcactccac cttcttccca gccctgcagg gcgcccagac caaaatgagt      540

gccagcgacc ccaactcctc catcttcctc accgacacgg ccaagcagat caaaaccaag      600

gtcaataagc atgcgttttc tggagggaga gacaccatcg aggagcacag gcagtttggg      660

ggcaactgtg atgtggacgt gtctttcatg tacctgacct tcttcctcga ggacgacgac      720

aagctcgagc agatcaggaa ggattacacc agcggagcca tgctcaccgg tgagctcaag      780

aaggcactca tagaggttct gcagcccttg atcgcagagc accaggcccg gcgcaaggag      840

gtcacggatg agatagtgaa agagttcatg actccccgga agctgtcctt cgactttcag      900

tag                                                                    903


<210>  169
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Leu Val Ser Leu Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp 
1               5                   10                  15      


Tyr Lys Ala Asp Cys Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His 
            20                  25                  30          


Gly Pro Asp Ala Thr Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr 
        35                  40                  45              


Val Gln Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val 
    50                  55                  60                  


Arg Phe Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu 
65                  70                  75                  80  


Arg Ala Thr Gly Gln Arg Pro His His Phe Leu Arg Arg Gly Ile Phe 
                85                  90                  95      


Phe Ser His Arg Asp Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys 
            100                 105                 110         


Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met 
        115                 120                 125             


His Val Gly His Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp 
    130                 135                 140                 


Val Phe Asn Val Pro Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr 
145                 150                 155                 160 


Leu Trp Lys Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu 
                165                 170                 175     


Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe 
            180                 185                 190         


Ile Phe Ser Asp Leu Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys 
        195                 200                 205             


Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly 
    210                 215                 220                 


Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro 
225                 230                 235                 240 


Ala Ile Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe 
                245                 250                 255     


Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln 
            260                 265                 270         


Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr 
        275                 280                 285             


Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly 
    290                 295                 300                 


Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu 
305                 310                 315                 320 


Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys Asp Tyr Thr Ser Gly Ala 
                325                 330                 335     


Met Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu Val Leu Gln Pro 
            340                 345                 350         


Leu Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val Thr Asp Glu Ile 
        355                 360                 365             


Val Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln 
    370                 375                 380             


<210>  170
<211>  1152
<212>  DNA
<213>  Homo sapiens

<400>  170
atgttggtgt cattaaaaat gagctacaaa gctgccgcgg gggaggatta caaggctgac       60

tgtcctccag ggaacccagc acctaccagt aatcatggcc cagatgccac agaagctgaa      120

gaggattttg tggacccatg gacagtacag acaagcagtg caaaaggcat agactacgat      180

aagctcattg ttcggtttgg aagtagtaaa attgacaaag agctaataaa ccgaatagag      240

agagccaccg gccaaagacc acaccacttc ctgcgcagag gcatcttctt ctcacacaga      300

gatatgaatc aggttcttga tgcctatgaa aataagaagc cattttatct gtacacgggc      360

cggggcccct cttctgaagc aatgcatgta ggtcacctca ttccatttat tttcacaaag      420

tggctccagg atgtatttaa cgtgcccttg gtcatccaga tgacggatga cgagaagtat      480

ctgtggaagg acctgaccct ggaccaggcc tatagctatg ctgtggagaa tgccaaggac      540

atcatcgcct gtggctttga catcaacaag actttcatat tctctgacct ggactacatg      600

gggatgagct caggtttcta caaaaatgtg gtgaagattc aaaagcatgt taccttcaac      660

caagtgaaag gcattttcgg cttcactgac agcgactgca ttgggaagat cagttttcct      720

gccatccagg ctgctccctc cttcagcaac tcattcccac agatcttccg agacaggacg      780

gatatccagt gccttatccc atgtgccatt gaccaggatc cttactttag aatgacaagg      840

gacgtcgccc ccaggatcgg ctatcctaaa ccagccctgc tgcactccac cttcttccca      900

gccctgcagg gcgcccagac caaaatgagt gccagcgacc ccaactcctc catcttcctc      960

accgacacgg ccaagcagat caaaaccaag gattacacca gcggagccat gctcaccggt     1020

gagctcaaga aggcactcat agaggttctg cagcccttga tcgcagagca ccaggcccgg     1080

cgcaaggagg tcacggatga gatagtgaaa gagttcatga ctccccggaa gctgtccttc     1140

gactttcagt ag                                                         1152


<210>  171
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu 
1               5                   10                  15      


Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu 
            20                  25                  30          


Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro 
        35                  40                  45              


Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu 
    50                  55                  60                  


Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile 
65                  70                  75                  80  


Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu 
                85                  90                  95      


Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile 
            100                 105                 110         


Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr 
        115                 120                 125             


Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala 
    130                 135                 140                 


Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp 
145                 150                 155                 160 


Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg 
                165                 170                 175     


Met Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu 
            180                 185                 190         


Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met 
        195                 200                 205             


Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys 
    210                 215                 220                 


Gln Ile Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp 
225                 230                 235                 240 


Thr Ile Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val 
                245                 250                 255     


Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu 
            260                 265                 270         


Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu 
        275                 280                 285             


Lys Lys Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln 
    290                 295                 300                 


Ala Arg Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr 
305                 310                 315                 320 


Pro Arg Lys Leu Ser Phe Asp Phe Gln 
                325                 


<210>  172
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  172
atgaatcagg ttcttgatgc ctatgaaaat aagaagccat tttatctgta cacgggccgg       60

ggcccctctt ctgaagcaat gcatgtaggt cacctcattc catttatttt cacaaagtgg      120

ctccaggatg tatttaacgt gcccttggtc atccagatga cggatgacga gaagtatctg      180

tggaaggacc tgaccctgga ccaggcctat agctatgctg tggagaatgc caaggacatc      240

atcgcctgtg gctttgacat caacaagact ttcatattct ctgacctgga ctacatgggg      300

atgagctcag gtttctacaa aaatgtggtg aagattcaaa agcatgttac cttcaaccaa      360

gtgaaaggca ttttcggctt cactgacagc gactgcattg ggaagatcag ttttcctgcc      420

atccaggctg ctccctcctt cagcaactca ttcccacaga tcttccgaga caggacggat      480

atccagtgcc ttatcccatg tgccattgac caggatcctt actttagaat gacaagggac      540

gtcgccccca ggatcggcta tcctaaacca gccctgctgc actccacctt cttcccagcc      600

ctgcagggcg cccagaccaa aatgagtgcc agcgacccca actcctccat cttcctcacc      660

gacacggcca agcagatcaa aaccaaggtc aataagcatg cgttttctgg agggagagac      720

accatcgagg agcacaggca gtttgggggc aactgtgatg tggacgtgtc tttcatgtac      780

ctgaccttct tcctcgagga cgacgacaag ctcgagcaga tcaggaagga ttacaccagc      840

ggagccatgc tcaccggtga gctcaagaag gcactcatag aggttctgca gcccttgatc      900

gcagagcacc aggcccggcg caaggaggtc acggatgaga tagtgaaaga gttcatgact      960

ccccggaagc tgtccttcga ctttcagtag                                       990


<210>  173
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  173

Thr Phe Ile Phe Ser Asp Leu Glu Tyr Met Gly Gln Ser Pro Gly Phe 
1               5                   10                  15      


Tyr Arg 
        


<210>  174
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  174
tattctctga cctggactac atgggggaag atcagttttc ctgccatcca                  50


<210>  175
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  175

Tyr Ser Leu Thr Trp Thr Thr Trp Gly Lys Ile Ser Phe Pro Ala Ile 
1               5                   10                  15      


<210>  176
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  176
ggcatagact acgataagct cattgggaag atcagttttc ctgccatcca                  50


<210>  177
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  177

Gly Ile Asp Tyr Asp Lys Leu Ile Gly Lys Ile Ser Phe Pro Ala Ile 
1               5                   10                  15      


<210>  178
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  178
cacggccaag cagatcaaaa ccaaggatta caccagcgga gccatgctca                  50


<210>  179
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  179

Thr Ala Lys Gln Ile Lys Thr Lys Asp Tyr Thr Ser Gly Ala Met Leu 
1               5                   10                  15      


<210>  180
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  180
gcgctgactg gcccggctgg gcaggagata tgaatcaggt tcttgatgcc                  50


<210>  181
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro 
1               5                   10                  15      


Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu 
            20                  25                  30          


Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala 
        35                  40                  45              


Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys 
    50                  55                  60                  


Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg 
65                  70                  75                  80  


Pro His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met 
                85                  90                  95      


Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr 
            100                 105                 110         


Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile 
        115                 120                 125             


Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu 
    130                 135                 140                 


Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr 
145                 150                 155                 160 


Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile 
                165                 170                 175     


Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp 
            180                 185                 190         


Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln 
        195                 200                 205             


Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp 
    210                 215                 220                 


Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro 
225                 230                 235                 240 


Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile 
                245                 250                 255     


Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met 
            260                 265                 270         


Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu 
        275                 280                 285             


His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser 
    290                 295                 300                 


Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln 
305                 310                 315                 320 


Ile Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr 
                325                 330                 335     


Ile Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser 
            340                 345                 350         


Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln 
        355                 360                 365             


Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys 
    370                 375                 380                 


Lys Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala 
385                 390                 395                 400 


Arg Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro 
                405                 410                 415     


Arg Lys Leu Ser Phe Asp Phe Gln 
            420                 


<210>  182
<211>  1275
<212>  DNA
<213>  Homo sapiens

<400>  182
atgagctaca aagctgccgc gggggaggat tacaaggctg actgtcctcc agggaaccca       60

gcacctacca gtaatcatgg cccagatgcc acagaagctg aagaggattt tgtggaccca      120

tggacagtac agacaagcag tgcaaaaggc atagactacg ataagctcat tgttcggttt      180

ggaagtagta aaattgacaa agagctaata aaccgaatag agagagccac cggccaaaga      240

ccacaccact tcctgcgcag aggcatcttc ttctcacaca gagatatgaa tcaggttctt      300

gatgcctatg aaaataagaa gccattttat ctgtacacgg gccggggccc ctcttctgaa      360

gcaatgcatg taggtcacct cattccattt attttcacaa agtggctcca ggatgtattt      420

aacgtgccct tggtcatcca gatgacggat gacgagaagt atctgtggaa ggacctgacc      480

ctggaccagg cctatagcta tgctgtggag aatgccaagg acatcatcgc ctgtggcttt      540

gacatcaaca agactttcat attctctgac ctggactaca tggggatgag ctcaggtttc      600

tacaaaaatg tggtgaagat tcaaaagcat gttaccttca accaagtgaa aggcattttc      660

ggcttcactg acagcgactg cattgggaag atcagttttc ctgccatcca ggctgctccc      720

tccttcagca actcattccc acagatcttc cgagacagga cggatatcca gtgccttatc      780

ccatgtgcca ttgaccagga tccttacttt agaatgacaa gggacgtcgc ccccaggatc      840

ggctatccta aaccagccct gctgcactcc accttcttcc cagccctgca gggcgcccag      900

accaaaatga gtgccagcga ccccaactcc tccatcttcc tcaccgacac ggccaagcag      960

atcaaaacca aggtcaataa gcatgcgttt tctggaggga gagacaccat cgaggagcac     1020

aggcagtttg ggggcaactg tgatgtggac gtgtctttca tgtacctgac cttcttcctc     1080

gaggacgacg acaagctcga gcagatcagg aaggattaca ccagcggagc catgctcacc     1140

ggtgagctca agaaggcact catagaggtt ctgcagccct tgatcgcaga gcaccaggcc     1200

cggcgcaagg aggtcacgga tgagatagtg aaagagttca tgactccccg gaagctgtcc     1260

ttcgactttc agtag                                                      1275


<210>  183
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  183

Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser 
1               5                   10                  15      


Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly 
            20                  25                  30          


Gln Arg Pro His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg 
        35                  40                  45              


Asp Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr 
    50                  55                  60                  


Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His 
65                  70                  75                  80  


Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val 
                85                  90                  95      


Pro Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp 
            100                 105                 110         


Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp 
        115                 120                 125             


Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp 
    130                 135                 140                 


Leu Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys 
145                 150                 155                 160 


Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe 
                165                 170                 175     


Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala 
            180                 185                 190         


Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr 
        195                 200                 205             


Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe 
    210                 215                 220                 


Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala 
225                 230                 235                 240 


Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys 
                245                 250                 255     


Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala 
            260                 265                 270         


Lys Gln Ile Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg 
        275                 280                 285             


Asp Thr Ile Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp 
    290                 295                 300                 


Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu 
305                 310                 315                 320 


Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu 
                325                 330                 335     


Leu Lys Lys Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His 
            340                 345                 350         


Gln Ala Arg Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met 
        355                 360                 365             


Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln 
    370                 375             


<210>  184
<211>  1137
<212>  DNA
<213>  Homo sapiens

<400>  184
agtgcaaaag gcatagacta cgataagctc attgttcggt ttggaagtag taaaattgac       60

aaagagctaa taaaccgaat agagagagcc accggccaaa gaccacacca cttcctgcgc      120

agaggcatct tcttctcaca cagagatatg aatcaggttc ttgatgccta tgaaaataag      180

aagccatttt atctgtacac gggccggggc ccctcttctg aagcaatgca tgtaggtcac      240

ctcattccat ttattttcac aaagtggctc caggatgtat ttaacgtgcc cttggtcatc      300

cagatgacgg atgacgagaa gtatctgtgg aaggacctga ccctggacca ggcctatagc      360

tatgctgtgg agaatgccaa ggacatcatc gcctgtggct ttgacatcaa caagactttc      420

atattctctg acctggacta catggggatg agctcaggtt tctacaaaaa tgtggtgaag      480

attcaaaagc atgttacctt caaccaagtg aaaggcattt tcggcttcac tgacagcgac      540

tgcattggga agatcagttt tcctgccatc caggctgctc cctccttcag caactcattc      600

ccacagatct tccgagacag gacggatatc cagtgcctta tcccatgtgc cattgaccag      660

gatccttact ttagaatgac aagggacgtc gcccccagga tcggctatcc taaaccagcc      720

ctgctgcact ccaccttctt cccagccctg cagggcgccc agaccaaaat gagtgccagc      780

gaccccaact cctccatctt cctcaccgac acggccaagc agatcaaaac caaggtcaat      840

aagcatgcgt tttctggagg gagagacacc atcgaggagc acaggcagtt tgggggcaac      900

tgtgatgtgg acgtgtcttt catgtacctg accttcttcc tcgaggacga cgacaagctc      960

gagcagatca ggaaggatta caccagcgga gccatgctca ccggtgagct caagaaggca     1020

ctcatagagg ttctgcagcc cttgatcgca gagcaccagg cccggcgcaa ggaggtcacg     1080

gatgagatag tgaaagagtt catgactccc cggaagctgt ccttcgactt tcagtag        1137


<210>  185
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  185

Ser Gly Gly Arg Asp Thr Ile Glu Glu His Arg Gln Phe Gly Gly Asn 
1               5                   10                  15      


Cys Asp Val Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp 
            20                  25                  30          


Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met 
        35                  40                  45              


Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu Val Leu Gln Pro Leu 
    50                  55                  60                  


Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val Thr Asp Glu Ile Val 
65                  70                  75                  80  


Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln 
                85                  90                  


<210>  186
<211>  285
<212>  DNA
<213>  Homo sapiens

<400>  186
tctggaggga gagacaccat cgaggagcac aggcagtttg ggggcaactg tgatgtggac       60

gtgtctttca tgtacctgac cttcttcctc gaggacgacg acaagctcga gcagatcagg      120

aaggattaca ccagcggagc catgctcacc ggtgagctca agaaggcact catagaggtt      180

ctgcagccct tgatcgcaga gcaccaggcc cggcgcaagg aggtcacgga tgagatagtg      240

aaagagttca tgactccccg gaagctgtcc ttcgactttc agtag                      285


<210>  187
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  187

Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile 
1               5                   10                  15      


Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp 
            20                  25                  30          


Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln 
        35                  40                  45              


Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp 
    50                  55                  60                  


Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro 
65                  70                  75                  80  


Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile 
                85                  90                  95      


Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met 
            100                 105                 110         


Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu 
        115                 120                 125             


His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser 
    130                 135                 140                 


Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln 
145                 150                 155                 160 


Ile Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr 
                165                 170                 175     


Ile Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser 
            180                 185                 190         


Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln 
        195                 200                 205             


Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys 
    210                 215                 220                 


Lys Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala 
225                 230                 235                 240 


Arg Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro 
                245                 250                 255     


Arg Lys Leu Ser Phe Asp Phe Gln 
            260                 


<210>  188
<211>  795
<212>  DNA
<213>  Homo sapiens

<400>  188
ctggaccagg cctatagcta tgctgtggag aatgccaagg acatcatcgc ctgtggcttt       60

gacatcaaca agactttcat attctctgac ctggactaca tggggatgag ctcaggtttc      120

tacaaaaatg tggtgaagat tcaaaagcat gttaccttca accaagtgaa aggcattttc      180

ggcttcactg acagcgactg cattgggaag atcagttttc ctgccatcca ggctgctccc      240

tccttcagca actcattccc acagatcttc cgagacagga cggatatcca gtgccttatc      300

ccatgtgcca ttgaccagga tccttacttt agaatgacaa gggacgtcgc ccccaggatc      360

ggctatccta aaccagccct gctgcactcc accttcttcc cagccctgca gggcgcccag      420

accaaaatga gtgccagcga ccccaactcc tccatcttcc tcaccgacac ggccaagcag      480

atcaaaacca aggtcaataa gcatgcgttt tctggaggga gagacaccat cgaggagcac      540

aggcagtttg ggggcaactg tgatgtggac gtgtctttca tgtacctgac cttcttcctc      600

gaggacgacg acaagctcga gcagatcagg aaggattaca ccagcggagc catgctcacc      660

ggtgagctca agaaggcact catagaggtt ctgcagccct tgatcgcaga gcaccaggcc      720

cggcgcaagg aggtcacgga tgagatagtg aaagagttca tgactccccg gaagctgtcc      780

ttcgactttc agtag                                                       795


<210>  189
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  189

Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr 
1               5                   10                  15      


Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys 
            20                  25                  30          


His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser 
        35                  40                  45              


Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser 
    50                  55                  60                  


Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln 
65                  70                  75                  80  


Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr 
                85                  90                  95      


Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His 
            100                 105                 110         


Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala 
        115                 120                 125             


Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile 
    130                 135                 140                 


Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile 
145                 150                 155                 160 


Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe 
                165                 170                 175     


Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile 
            180                 185                 190         


Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys 
        195                 200                 205             


Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg 
    210                 215                 220                 


Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg 
225                 230                 235                 240 


Lys Leu Ser Phe Asp Phe Gln 
                245         


<210>  190
<211>  744
<212>  DNA
<213>  Homo sapiens

<400>  190
tgtggctttg acatcaacaa gactttcata ttctctgacc tggactacat ggggatgagc       60

tcaggtttct acaaaaatgt ggtgaagatt caaaagcatg ttaccttcaa ccaagtgaaa      120

ggcattttcg gcttcactga cagcgactgc attgggaaga tcagttttcc tgccatccag      180

gctgctccct ccttcagcaa ctcattccca cagatcttcc gagacaggac ggatatccag      240

tgccttatcc catgtgccat tgaccaggat ccttacttta gaatgacaag ggacgtcgcc      300

cccaggatcg gctatcctaa accagccctg ctgcactcca ccttcttccc agccctgcag      360

ggcgcccaga ccaaaatgag tgccagcgac cccaactcct ccatcttcct caccgacacg      420

gccaagcaga tcaaaaccaa ggtcaataag catgcgtttt ctggagggag agacaccatc      480

gaggagcaca ggcagtttgg gggcaactgt gatgtggacg tgtctttcat gtacctgacc      540

ttcttcctcg aggacgacga caagctcgag cagatcagga aggattacac cagcggagcc      600

atgctcaccg gtgagctcaa gaaggcactc atagaggttc tgcagccctt gatcgcagag      660

caccaggccc ggcgcaagga ggtcacggat gagatagtga aagagttcat gactccccgg      720

aagctgtcct tcgactttca gtag                                             744


<210>  191
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with N-terminal 6xHis 
       affinity tag

<400>  191

Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu 
1               5                   10                  15      


Gly Leu Asp Ser Thr Gly Ser Asn Lys Lys Pro Phe Tyr Leu Tyr Thr 
            20                  25                  30          


Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro 
        35                  40                  45              


Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val 
    50                  55                  60                  


Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu 
65                  70                  75                  80  


Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala 
                85                  90                  95      


Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr 
            100                 105                 110         


Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys 
        115                 120                 125             


His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser 
    130                 135                 140                 


Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser 
145                 150                 155                 160 


Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln 
                165                 170                 175     


Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr 
            180                 185                 190         


Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His 
        195                 200                 205             


Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala 
    210                 215                 220                 


Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile 
225                 230                 235                 240 


Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile 
                245                 250                 255     


Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe 
            260                 265                 270         


Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile 
        275                 280                 285             


Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys 
    290                 295                 300                 


Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg 
305                 310                 315                 320 


Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg 
                325                 330                 335     


Lys Leu Ser Phe Asp Phe Gln Leu Glu 
            340                 345 


<210>  192
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with C-terminal 6xHis 
       affinity tag

<400>  192

Met Gly Ser Asn Lys Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro 
1               5                   10                  15      


Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro Phe Ile Phe Thr 
            20                  25                  30          


Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val Ile Gln Met Thr 
        35                  40                  45              


Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu Asp Gln Ala Tyr 
    50                  55                  60                  


Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp 
65                  70                  75                  80  


Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr Met Gly Met Ser 
                85                  90                  95      


Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys His Val Thr Phe 
            100                 105                 110         


Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly 
        115                 120                 125             


Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser Phe Ser Asn Ser 
    130                 135                 140                 


Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro 
145                 150                 155                 160 


Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala 
                165                 170                 175     


Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe 
            180                 185                 190         


Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn 
        195                 200                 205             


Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys Val 
    210                 215                 220                 


Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile Glu Glu His Arg 
225                 230                 235                 240 


Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe Met Tyr Leu Thr 
                245                 250                 255     


Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp Tyr 
            260                 265                 270         


Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu 
        275                 280                 285             


Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val 
    290                 295                 300                 


Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe 
305                 310                 315                 320 


Asp Phe Gln Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
                325                 330                 335     


Asp Ser Thr His His His His His His 
            340                 345 


<210>  193
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with N-terminal 6xHis 
       affinity tag

<400>  193

Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu 
1               5                   10                  15      


Gly Leu Asp Ser Thr Gly Ser Gly Lys Ile Ser Phe Pro Ala Ile Gln 
            20                  25                  30          


Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg 
        35                  40                  45              


Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr 
    50                  55                  60                  


Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro 
65                  70                  75                  80  


Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr 
                85                  90                  95      


Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr 
            100                 105                 110         


Ala Lys Gln Ile Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly 
        115                 120                 125             


Arg Asp Thr Ile Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val 
    130                 135                 140                 


Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys 
145                 150                 155                 160 


Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly 
                165                 170                 175     


Glu Leu Lys Lys Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu 
            180                 185                 190         


His Gln Ala Arg Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe 
        195                 200                 205             


Met Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln Leu Glu 
    210                 215                 220     


<210>  194
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with C-terminal 6xHis 
       affinity tag

<400>  194

Met Gly Ser Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser 
1               5                   10                  15      


Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln 
            20                  25                  30          


Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr 
        35                  40                  45              


Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His 
    50                  55                  60                  


Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala 
65                  70                  75                  80  


Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile 
                85                  90                  95      


Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile 
            100                 105                 110         


Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe 
        115                 120                 125             


Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile 
    130                 135                 140                 


Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys 
145                 150                 155                 160 


Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg 
                165                 170                 175     


Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg 
            180                 185                 190         


Lys Leu Ser Phe Asp Phe Gln Leu Glu Gly Lys Pro Ile Pro Asn Pro 
        195                 200                 205             


Leu Leu Gly Leu Asp Ser Thr His His His His His His 
    210                 215                 220     


<210>  195
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with N-terminal 6xHis 
       affinity tag

<400>  195

Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu 
1               5                   10                  15      


Gly Leu Asp Ser Thr Gly Ser Ile Phe Arg Asp Arg Thr Asp Ile Gln 
            20                  25                  30          


Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr 
        35                  40                  45              


Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His 
    50                  55                  60                  


Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala 
65                  70                  75                  80  


Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile 
                85                  90                  95      


Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile 
            100                 105                 110         


Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe 
        115                 120                 125             


Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile 
    130                 135                 140                 


Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys 
145                 150                 155                 160 


Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg 
                165                 170                 175     


Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg 
            180                 185                 190         


Lys Leu Ser Phe Asp Phe Leu Glu 
        195                 200 


<210>  196
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with C-terminal 6xHis 
       affinity tag

<400>  196

Met Gly Ser Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro 
1               5                   10                  15      


Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala 
            20                  25                  30          


Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe 
        35                  40                  45              


Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn 
    50                  55                  60                  


Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys Val 
65                  70                  75                  80  


Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile Glu Glu His Arg 
                85                  90                  95      


Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe Met Tyr Leu Thr 
            100                 105                 110         


Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp Tyr 
        115                 120                 125             


Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu 
    130                 135                 140                 


Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val 
145                 150                 155                 160 


Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe 
                165                 170                 175     


Asp Phe Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp 
            180                 185                 190         


Ser Thr His His His His His His 
        195                 200 


<210>  197
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with N-terminal 6xHis 
       affinity tag

<400>  197

Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu 
1               5                   10                  15      


Gly Leu Asp Ser Thr Gly Ser Ser Gly Gly Arg Asp Thr Ile Glu Glu 
            20                  25                  30          


His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe Met Tyr 
        35                  40                  45              


Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile Arg Lys 
    50                  55                  60                  


Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys Ala Leu 
65                  70                  75                  80  


Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg Arg Lys 
                85                  90                  95      


Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg Lys Leu 
            100                 105                 110         


Ser Phe Asp Phe Gln Leu Glu 
        115                 


<210>  198
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with C-terminal 6xHis 
       affinity tag

<400>  198

Met Gly Ser Ser Gly Gly Arg Asp Thr Ile Glu Glu His Arg Gln Phe 
1               5                   10                  15      


Gly Gly Asn Cys Asp Val Asp Val Ser Phe Met Tyr Leu Thr Phe Phe 
            20                  25                  30          


Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser 
        35                  40                  45              


Gly Ala Met Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu Val Leu 
    50                  55                  60                  


Gln Pro Leu Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val Thr Asp 
65                  70                  75                  80  


Glu Ile Val Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe Asp Phe 
                85                  90                  95      


Gln Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser 
            100                 105                 110         


Thr His His His His His His 
        115                 


<210>  199
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with N-terminal 6xHis 
       affinity tag

<400>  199

Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu 
1               5                   10                  15      


Gly Leu Asp Ser Thr Gly Ser Leu Val Ser Leu Lys Met Ser Tyr Lys 
            20                  25                  30          


Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro Gly Asn Pro 
        35                  40                  45              


Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala Glu Glu Asp 
    50                  55                  60                  


Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys Gly Ile Asp 
65                  70                  75                  80  


Tyr Asp Lys Leu Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala 
                85                  90                  95      


Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp 
            100                 105                 110         


Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg 
        115                 120                 125             


Met Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu 
    130                 135                 140                 


Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met 
145                 150                 155                 160 


Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys 
                165                 170                 175     


Gln Ile Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp 
            180                 185                 190         


Thr Ile Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val 
        195                 200                 205             


Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu 
    210                 215                 220                 


Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu 
225                 230                 235                 240 


Lys Lys Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln 
                245                 250                 255     


Ala Arg Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr 
            260                 265                 270         


Pro Arg Lys Leu Ser Phe Asp Phe Gln Leu Glu 
        275                 280             


<210>  200
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with C-terminal 6xHis 
       affinity tag

<400>  200

Met Gly Ser Leu Val Ser Leu Lys Met Ser Tyr Lys Ala Ala Ala Gly 
1               5                   10                  15      


Glu Asp Tyr Lys Ala Asp Cys Pro Pro Gly Asn Pro Ala Pro Thr Ser 
            20                  25                  30          


Asn His Gly Pro Asp Ala Thr Glu Ala Glu Glu Asp Phe Val Asp Pro 
        35                  40                  45              


Trp Thr Val Gln Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu 
    50                  55                  60                  


Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser Phe Ser 
65                  70                  75                  80  


Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu 
                85                  90                  95      


Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp 
            100                 105                 110         


Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His Ser Thr 
        115                 120                 125             


Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala Ser Asp 
    130                 135                 140                 


Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile Lys Thr 
145                 150                 155                 160 


Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile Glu Glu 
                165                 170                 175     


His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe Met Tyr 
            180                 185                 190         


Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile Arg Lys 
        195                 200                 205             


Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys Ala Leu 
    210                 215                 220                 


Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg Arg Lys 
225                 230                 235                 240 


Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg Lys Leu 
                245                 250                 255     


Ser Phe Asp Phe Gln Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu 
            260                 265                 270         


Gly Leu Asp Ser Thr His His His His His His 
        275                 280             


<210>  201
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with N-terminal 6xHis 
       affinity tag

<400>  201

Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu 
1               5                   10                  15      


Gly Leu Asp Ser Thr Gly Ser Pro Asn Ser Glu Pro Ala Ser Leu Leu 
            20                  25                  30          


Glu Leu Phe Asn Ser Ile Ala Thr Gln Gly Glu Leu Val Arg Ser Leu 
        35                  40                  45              


Lys Ala Gly Asn Ala Ser Lys Asp Glu Ile Asp Ser Ala Val Lys Met 
    50                  55                  60                  


Leu Val Ser Leu Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr 
65                  70                  75                  80  


Lys Ala Asp Cys Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly 
                85                  90                  95      


Pro Asp Ala Thr Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val 
            100                 105                 110         


Gln Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Gly Lys 
        115                 120                 125             


Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe 
    130                 135                 140                 


Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys 
145                 150                 155                 160 


Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro 
                165                 170                 175     


Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro 
            180                 185                 190         


Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser 
        195                 200                 205             


Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys Val Asn 
    210                 215                 220                 


Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile Glu Glu His Arg Gln 
225                 230                 235                 240 


Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe Met Tyr Leu Thr Phe 
                245                 250                 255     


Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp Tyr Thr 
            260                 265                 270         


Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu Val 
        275                 280                 285             


Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val Thr 
    290                 295                 300                 


Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe Asp 
305                 310                 315                 320 


Phe Gln Leu Glu 
                


<210>  202
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with C-terminal 6xHis 
       affinity tag

<400>  202

Met Gly Ser Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn 
1               5                   10                  15      


Ser Ile Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn 
            20                  25                  30          


Ala Ser Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu 
        35                  40                  45              


Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys 
    50                  55                  60                  


Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr 
65                  70                  75                  80  


Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser 
                85                  90                  95      


Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Gly Lys Ile Ser Phe Pro 
            100                 105                 110         


Ala Ile Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe 
        115                 120                 125             


Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln 
    130                 135                 140                 


Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr 
145                 150                 155                 160 


Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly 
                165                 170                 175     


Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu 
            180                 185                 190         


Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys Val Asn Lys His Ala Phe 
        195                 200                 205             


Ser Gly Gly Arg Asp Thr Ile Glu Glu His Arg Gln Phe Gly Gly Asn 
    210                 215                 220                 


Cys Asp Val Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp 
225                 230                 235                 240 


Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met 
                245                 250                 255     


Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu Val Leu Gln Pro Leu 
            260                 265                 270         


Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val Thr Asp Glu Ile Val 
        275                 280                 285             


Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln Leu Glu 
    290                 295                 300                 


Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His 
305                 310                 315                 320 


His His His His 
                


<210>  203
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with N-terminal 6xHis 
       affinity tag

<400>  203

Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu 
1               5                   10                  15      


Gly Leu Asp Ser Thr Gly Ser Leu Val Ser Leu Lys Met Ser Tyr Lys 
            20                  25                  30          


Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro Gly Asn Pro 
        35                  40                  45              


Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala Glu Glu Asp 
    50                  55                  60                  


Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys Gly Ile Asp 
65                  70                  75                  80  


Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile Asp Lys Glu 
                85                  90                  95      


Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro His His Phe 
            100                 105                 110         


Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn Gln Val Leu 
        115                 120                 125             


Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly 
    130                 135                 140                 


Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro Phe Ile Phe 
145                 150                 155                 160 


Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val Ile Gln Met 
                165                 170                 175     


Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu Asp Gln Ala 
            180                 185                 190         


Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe 
        195                 200                 205             


Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr Met Gly Met 
    210                 215                 220                 


Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys His Val Thr 
225                 230                 235                 240 


Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile 
                245                 250                 255     


Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser Phe Ser Asn 
            260                 265                 270         


Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile 
        275                 280                 285             


Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val 
    290                 295                 300                 


Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His Ser Thr Phe 
305                 310                 315                 320 


Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala Ser Asp Pro 
                325                 330                 335     


Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys 
            340                 345                 350         


Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys Ala Leu 
        355                 360                 365             


Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg Arg Lys 
    370                 375                 380                 


Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg Lys Leu 
385                 390                 395                 400 


Ser Phe Asp Phe Gln Leu Glu 
                405         


<210>  204
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with C-terminal 6xHis 
       affinity tag

<400>  204

Met Gly Ser Leu Val Ser Leu Lys Met Ser Tyr Lys Ala Ala Ala Gly 
1               5                   10                  15      


Glu Asp Tyr Lys Ala Asp Cys Pro Pro Gly Asn Pro Ala Pro Thr Ser 
            20                  25                  30          


Asn His Gly Pro Asp Ala Thr Glu Ala Glu Glu Asp Phe Val Asp Pro 
        35                  40                  45              


Trp Thr Val Gln Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu 
    50                  55                  60                  


Ile Val Arg Phe Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg 
65                  70                  75                  80  


Ile Glu Arg Ala Thr Gly Gln Arg Pro His His Phe Leu Arg Arg Gly 
                85                  90                  95      


Ile Phe Phe Ser His Arg Asp Met Asn Gln Val Leu Asp Ala Tyr Glu 
            100                 105                 110         


Asn Lys Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu 
        115                 120                 125             


Ala Met His Val Gly His Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu 
    130                 135                 140                 


Gln Asp Val Phe Asn Val Pro Leu Val Ile Gln Met Thr Asp Asp Glu 
145                 150                 155                 160 


Lys Tyr Leu Trp Lys Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala 
                165                 170                 175     


Val Glu Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys 
            180                 185                 190         


Thr Phe Ile Phe Ser Asp Leu Asp Tyr Met Gly Met Ser Ser Gly Phe 
        195                 200                 205             


Tyr Lys Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val 
    210                 215                 220                 


Lys Gly Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser 
225                 230                 235                 240 


Phe Pro Ala Ile Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln 
                245                 250                 255     


Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile 
            260                 265                 270         


Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile 
        275                 280                 285             


Gly Tyr Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu 
    290                 295                 300                 


Gln Gly Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile 
305                 310                 315                 320 


Phe Leu Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys Asp Tyr Thr Ser 
                325                 330                 335     


Gly Ala Met Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu Val Leu 
            340                 345                 350         


Gln Pro Leu Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val Thr Asp 
        355                 360                 365             


Glu Ile Val Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe Asp Phe 
    370                 375                 380                 


Gln Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser 
385                 390                 395                 400 


Thr His His His His His His 
                405         


<210>  205
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with N-terminal 6xHis 
       affinity tag

<400>  205

Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu 
1               5                   10                  15      


Gly Leu Asp Ser Thr Gly Ser Leu Asp Gln Ala Tyr Ser Tyr Ala Val 
            20                  25                  30          


Glu Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr 
        35                  40                  45              


Phe Ile Phe Ser Asp Leu Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr 
    50                  55                  60                  


Lys Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys 
65                  70                  75                  80  


Gly Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe 
                85                  90                  95      


Pro Ala Ile Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile 
            100                 105                 110         


Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp 
        115                 120                 125             


Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly 
    130                 135                 140                 


Tyr Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln 
145                 150                 155                 160 


Gly Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe 
                165                 170                 175     


Leu Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys Val Asn Lys His Ala 
            180                 185                 190         


Phe Ser Gly Gly Arg Asp Thr Ile Glu Glu His Arg Gln Phe Gly Gly 
        195                 200                 205             


Asn Cys Asp Val Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu 
    210                 215                 220                 


Asp Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala 
225                 230                 235                 240 


Met Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu Val Leu Gln Pro 
                245                 250                 255     


Leu Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val Thr Asp Glu Ile 
            260                 265                 270         


Val Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln Leu 
        275                 280                 285             


Glu 
    


<210>  206
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   Tryptophanyl tRNA Synthetase polypeptide with C-terminal 6xHis 
       affinity tag

<400>  206

Met Gly Ser Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys 
1               5                   10                  15      


Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser 
            20                  25                  30          


Asp Leu Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val 
        35                  40                  45              


Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly 
    50                  55                  60                  


Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln 
65                  70                  75                  80  


Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg 
                85                  90                  95      


Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr 
            100                 105                 110         


Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro 
        115                 120                 125             


Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr 
    130                 135                 140                 


Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr 
145                 150                 155                 160 


Ala Lys Gln Ile Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly 
                165                 170                 175     


Arg Asp Thr Ile Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val 
            180                 185                 190         


Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys 
        195                 200                 205             


Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly 
    210                 215                 220                 


Glu Leu Lys Lys Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu 
225                 230                 235                 240 


His Gln Ala Arg Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe 
                245                 250                 255     


Met Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln Leu Glu Gly Lys Pro 
            260                 265                 270         


Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His 
        275                 280                 285             


His 
    


<210>  207
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with N-terminal 6xHis 
       affinity tag

<400>  207

Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu 
1               5                   10                  15      


Gly Leu Asp Ser Thr Gly Ser Asn Gln Val Leu Asp Ala Tyr Glu Asn 
            20                  25                  30          


Lys Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala 
        35                  40                  45              


Met His Val Gly His Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln 
    50                  55                  60                  


Asp Val Phe Asn Val Pro Leu Val Ile Gln Met Thr Asp Asp Glu Lys 
65                  70                  75                  80  


Tyr Leu Trp Lys Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val 
                85                  90                  95      


Glu Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr 
            100                 105                 110         


Phe Ile Phe Ser Asp Leu Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr 
        115                 120                 125             


Lys Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys 
    130                 135                 140                 


Gly Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe 
145                 150                 155                 160 


Pro Ala Ile Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile 
                165                 170                 175     


Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp 
            180                 185                 190         


Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly 
        195                 200                 205             


Tyr Pro Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln 
    210                 215                 220                 


Gly Ala Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe 
225                 230                 235                 240 


Leu Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys Val Asn Lys His Ala 
                245                 250                 255     


Phe Ser Gly Gly Arg Asp Thr Ile Glu Glu His Arg Gln Phe Gly Gly 
            260                 265                 270         


Asn Cys Asp Val Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu 
        275                 280                 285             


Asp Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala 
    290                 295                 300                 


Met Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu Val Leu Gln Pro 
305                 310                 315                 320 


Leu Ile Ala Glu His Gln Ala Arg Arg Lys Glu Val Thr Asp Glu Ile 
                325                 330                 335     


Val Lys Glu Phe Met Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln Leu 
            340                 345                 350         


Glu 
    


<210>  208
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with C-terminal 6xHis 
       affinity tag

<400>  208

Met Gly Ser Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe 
1               5                   10                  15      


Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly 
            20                  25                  30          


His Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn 
        35                  40                  45              


Val Pro Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys 
    50                  55                  60                  


Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys 
65                  70                  75                  80  


Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser 
                85                  90                  95      


Asp Leu Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val 
            100                 105                 110         


Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly 
        115                 120                 125             


Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln 
    130                 135                 140                 


Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg 
145                 150                 155                 160 


Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr 
                165                 170                 175     


Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro 
            180                 185                 190         


Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr 
        195                 200                 205             


Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr 
    210                 215                 220                 


Ala Lys Gln Ile Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly 
225                 230                 235                 240 


Arg Asp Thr Ile Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val 
                245                 250                 255     


Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys 
            260                 265                 270         


Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly 
        275                 280                 285             


Glu Leu Lys Lys Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu 
    290                 295                 300                 


His Gln Ala Arg Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe 
305                 310                 315                 320 


Met Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln Leu Glu Gly Lys Pro 
                325                 330                 335     


Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His 
            340                 345                 350         


His 
    


<210>  209
<211>  972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized tryptophanyl tRNA synthetase polynucleotide

<400>  209
ggatccaaca agaagccttt ttacctgtat accggccgtg gccctagtag cgaagccatg       60

cacgttggcc acctgatccc gttcatcttc accaagtggc tgcaggacgt tttcaatgtg      120

ccgctggtga tccaaatgac cgacgacgag aagtatctgt ggaaggacct gacactggac      180

caggcctaca gctacgccgt tgagaacgcc aaagacatta tcgcctgcgg cttcgacatt      240

aacaagacct tcatcttcag cgatctggac tatatgggca tgagcagtgg cttctacaaa      300

aatgtggtta aaatccagaa gcacgtgacc ttcaaccagg tgaagggcat cttcggcttc      360

accgacagcg actgcatcgg taagatcagt ttcccggcaa tccaggccgc cccgagtttc      420

agcaacagct ttccgcagat cttccgcgac cgcaccgata tccagtgcct gatcccgtgc      480

gccattgacc aggacccgta cttccgtatg acacgcgatg ttgcccctcg catcggttat      540

ccgaagccgg cattactgca cagcaccttc ttcccggcac tgcagggcgc acagacaaag      600

atgagcgcca gcgaccctaa cagcagcatc ttcctgaccg acaccgccaa acagatcaag      660

accaaggtga acaagcacgc cttcagtggc ggtcgtgaca caatcgagga acatcgccag      720

tttggtggca actgtgacgt ggacgtgagc ttcatgtacc tgaccttctt cctggaggac      780

gatgacaagc tggagcaaat ccgcaaggac tacacaagtg gcgcaatgct gaccggcgag      840

ttaaagaaag ccctgatcga ggtgttacag ccgctgatcg ccgaacatca agcccgtcgc      900

aaagaggtga cagacgagat cgtgaaggag ttcatgaccc cgcgcaagct gagcttcgat      960

ttccagctcg ag                                                          972


<210>  210
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized tryptophanyl tRNA synthetase

       polynucleotide

<400>  210
ggatccggca agatcagttt cccggccatc caggcagccc cgagcttcag caacagtttc       60

cctcagatct tccgcgaccg taccgacatt cagtgcctga ttccgtgcgc catcgaccag      120

gacccgtact tccgcatgac ccgtgacgtg gcaccgcgca ttggctaccc gaaaccggcc      180

ctgctgcata gtaccttctt tccggccctg cagggtgccc agacaaagat gagcgccagc      240

gacccgaata gcagcatctt cctgacagac acagcaaagc aaatcaagac aaaggtgaac      300

aaacacgcct ttagcggcgg ccgcgatacc atcgaagaac atcgccagtt cggtggcaac      360

tgcgacgttg atgtgagctt catgtacctg accttcttcc tggaggacga cgacaagctg      420

gagcagatcc gtaaggacta caccagcggt gccatgctga ccggcgagtt aaagaaggcc      480

ctgatcgaag tgctgcagcc gctgattgcc gagcatcaag cccgccgtaa agaggtgacc      540

gacgagatcg tgaaggagtt catgaccccg cgcaaactga gttttgactt ccaactcgag      600


<210>  211
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized tryptophanyl tRNA synthetase polynucleotide

<400>  211
ggatccatct tccgcgaccg taccgacatt cagtgcctga ttccgtgcgc catcgaccag       60

gacccgtact tccgcatgac ccgtgacgtg gcaccgcgca ttggctaccc gaaaccggcc      120

ctgctgcata gtaccttctt tccggccctg cagggtgccc agacaaagat gagcgccagc      180

gacccgaata gcagcatctt cctgacagac acagcaaagc aaatcaagac aaaggtgaac      240

aaacacgcct ttagcggcgg ccgcgatacc atcgaagaac atcgccagtt cggtggcaac      300

tgcgacgttg atgtgagctt catgtacctg accttcttcc tggaggacga cgacaagctg      360

gagcagatcc gtaaggacta caccagcggt gccatgctga ccggcgagtt aaagaaggcc      420

ctgatcgaag tgctgcagcc gctgattgcc gagcatcaag cccgccgtaa agaggtgacc      480

gacgagatcg tgaaggagtt catgaccccg cgcaaactga gttttgactt cctcgag         537


<210>  212
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized tryptophanyl tRNA synthetase polynucleotide

<400>  212
ggatccagcg gcggccgcga taccatcgaa gaacatcgcc agttcggtgg caactgcgac       60

gttgatgtga gcttcatgta cctgaccttc ttcctggagg acgacgacaa gctggagcag      120

atccgtaagg actacaccag cggtgccatg ctgaccggcg agttaaagaa ggccctgatc      180

gaagtgctgc agccgctgat tgccgagcat caagcccgcc gtaaagaggt gaccgacgag      240

atcgtgaagg agttcatgac cccgcgcaaa ctgagttttg acttccaact cgag            294


<210>  213
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized tryptophanyl tRNA synthetase polynucleotide

<400>  213
ggatccctgg accaggccta cagctacgcc gttgagaacg ccaaagacat tatcgcctgc       60

ggcttcgaca ttaacaagac cttcatcttc agcgatctgg actatatggg catgagcagt      120

ggcttctaca aaaatgtggt taaaatccag aagcacgtga ccttcaacca ggtgaagggc      180

atcttcggct tcaccgacag cgactgcatc ggtaagatca gtttcccggc aatccaggcc      240

gccccgagtt tcagcaacag ctttccgcag atcttccgcg accgcaccga tatccagtgc      300

ctgatcccgt gcgccattga ccaggacccg tacttccgta tgacacgcga tgttgcccct      360

cgcatcggtt atccgaagcc ggcattactg cacagcacct tcttcccggc actgcagggc      420

gcacagacaa agatgagcgc cagcgaccct aacagcagca tcttcctgac cgacaccgcc      480

aaacagatca agaccaaggt gaacaagcac gccttcagtg gcggtcgtga cacaatcgag      540

gaacatcgcc agtttggtgg caactgtgac gtggacgtga gcttcatgta cctgaccttc      600

ttcctggagg acgatgacaa gctggagcaa atccgcaagg actacacaag tggcgcaatg      660

ctgaccggcg agttaaagaa agccctgatc gaggtgttac agccgctgat cgccgaacat      720

caagcccgtc gcaaagaggt gacagacgag atcgtgaagg agttcatgac cccgcgcaag      780

ctgagcttcg atttccagct cgag                                             804


<210>  214
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized tryptophanyl tRNA synthetase polynucleotide

<400>  214
ggatccctgg tgagcctgaa gatgagctac aaggccgcag ccggcgagga ctacaaagcc       60

gactgtccgc cgggtaatcc ggcacctacc agcaaccatg gcccggacgc aaccgaagca      120

gaggaggatt tcgtggaccc gtggaccgtt cagaccagca gcgccaaggg catcgactac      180

gacaagctga tcggcaagat cagtttcccg gccatccagg cagccccgag cttcagcaac      240

agtttccctc agatcttccg cgaccgtacc gacattcagt gcctgattcc gtgcgccatc      300

gaccaggacc cgtacttccg catgacccgt gacgtggcac cgcgcattgg ctacccgaaa      360

ccggccctgc tgcatagtac cttctttccg gccctgcagg gtgcccagac aaagatgagc      420

gccagcgacc cgaatagcag catcttcctg acagacacag caaagcaaat caagacaaag      480

gtgaacaaac acgcctttag cggcggccgc gataccatcg aagaacatcg ccagttcggt      540

ggcaactgcg acgttgatgt gagcttcatg tacctgacct tcttcctgga ggacgacgac      600

aagctggagc agatccgtaa ggactacacc agcggtgcca tgctgaccgg cgagttaaag      660

aaggccctga tcgaagtgct gcagccgctg attgccgagc atcaagcccg ccgtaaagag      720

gtgaccgacg agatcgtgaa ggagttcatg accccgcgca aactgagttt tgacttccaa      780

ctcgag                                                                 786


<210>  215
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized tryptophanyl tRNA synthetase polynucleotide

<400>  215
ggatccccta acagcgaacc ggcaagtctg ctggagctgt tcaacagcat cgccacccag       60

ggtgagctgg tgcgcagctt aaaggcaggt aacgccagca aggacgagat tgacagcgcc      120

gtgaagatgc tggtgagcct gaagatgagc tacaaggccg cagccggcga ggactacaaa      180

gccgactgtc cgccgggtaa tccggcacct accagcaacc atggcccgga cgcaaccgaa      240

gcagaggagg atttcgtgga cccgtggacc gttcagacca gcagcgccaa gggcatcgac      300

tacgacaagc tgatcggcaa gatcagtttc ccggccatcc aggcagcccc gagcttcagc      360

aacagtttcc ctcagatctt ccgcgaccgt accgacattc agtgcctgat tccgtgcgcc      420

atcgaccagg acccgtactt ccgcatgacc cgtgacgtgg caccgcgcat tggctacccg      480

aaaccggccc tgctgcatag taccttcttt ccggccctgc agggtgccca gacaaagatg      540

agcgccagcg acccgaatag cagcatcttc ctgacagaca cagcaaagca aatcaagaca      600

aaggtgaaca aacacgcctt tagcggcggc cgcgatacca tcgaagaaca tcgccagttc      660

ggtggcaact gcgacgttga tgtgagcttc atgtacctga ccttcttcct ggaggacgac      720

gacaagctgg agcagatccg taaggactac accagcggtg ccatgctgac cggcgagtta      780

aagaaggccc tgatcgaagt gctgcagccg ctgattgccg agcatcaagc ccgccgtaaa      840

gaggtgaccg acgagatcgt gaaggagttc atgaccccgc gcaaactgag ttttgacttc      900

caactcgag                                                              909


<210>  216
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized tryptophanyl tRNA synthetase polynucleotide

<400>  216
ggatccctgg tgagtctgaa gatgagttac aaggccgccg ccggtgagga ctacaaggca       60

gactgtcctc ctggtaatcc ggcaccgacc agtaatcacg gtcctgacgc aaccgaggcc      120

gaagaggact ttgtggaccc gtggaccgtt caaaccagca gtgcaaaggg catcgactac      180

gacaagctga ttgtgcgctt cggcagcagc aagatcgaca aggagctgat taatcgcatc      240

gaacgcgcaa ccggtcaacg tcctcaccac ttcctgcgcc gcggtatctt cttcagtcac      300

cgcgacatga atcaggtgct ggacgcctac gaaaacaaga agccttttta cctgtatacc      360

ggccgtggcc ctagtagcga agccatgcac gttggccacc tgatcccgtt catcttcacc      420

aagtggctgc aggacgtttt caatgtgccg ctggtgatcc aaatgaccga cgacgagaag      480

tatctgtgga aggacctgac actggaccag gcctacagct acgccgttga gaacgccaaa      540

gacattatcg cctgcggctt cgacattaac aagaccttca tcttcagcga tctggactat      600

atgggcatga gcagtggctt ctacaaaaat gtggttaaaa tccagaagca cgtgaccttc      660

aaccaggtga agggcatctt cggcttcacc gacagcgact gcatcggtaa gatcagtttc      720

ccggcaatcc aggccgcccc gagtttcagc aacagctttc cgcagatctt ccgcgaccgc      780

accgatatcc agtgcctgat cccgtgcgcc attgaccagg acccgtactt ccgtatgaca      840

cgcgatgttg cccctcgcat cggttatccg aagccggcat tactgcacag caccttcttc      900

ccggcactgc agggcgcaca gacaaagatg agcgccagcg accctaacag cagcatcttc      960

ctgaccgaca ccgccaaaca gatcaagacc aaggactaca caagtggcgc catgctgaca     1020

ggcgagttaa aaaaggccct gatcgaggtg ctgcagcctc tgatcgccga acaccaggca     1080

cgccgcaagg aggtgaccga cgagattgtg aaggagttca tgaccccgcg caagttaagt     1140

ttcgacttcc agctcgag                                                   1158


<210>  217
<211>  996
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized tryptophanyl tRNA synthetase polynucleotide

<400>  217
ggatccaatc aggtgctgga cgcctacgaa aacaagaagc ctttttacct gtataccggc       60

cgtggcccta gtagcgaagc catgcacgtt ggccacctga tcccgttcat cttcaccaag      120

tggctgcagg acgttttcaa tgtgccgctg gtgatccaaa tgaccgacga cgagaagtat      180

ctgtggaagg acctgacact ggaccaggcc tacagctacg ccgttgagaa cgccaaagac      240

attatcgcct gcggcttcga cattaacaag accttcatct tcagcgatct ggactatatg      300

ggcatgagca gtggcttcta caaaaatgtg gttaaaatcc agaagcacgt gaccttcaac      360

caggtgaagg gcatcttcgg cttcaccgac agcgactgca tcggtaagat cagtttcccg      420

gcaatccagg ccgccccgag tttcagcaac agctttccgc agatcttccg cgaccgcacc      480

gatatccagt gcctgatccc gtgcgccatt gaccaggacc cgtacttccg tatgacacgc      540

gatgttgccc ctcgcatcgg ttatccgaag ccggcattac tgcacagcac cttcttcccg      600

gcactgcagg gcgcacagac aaagatgagc gccagcgacc ctaacagcag catcttcctg      660

accgacaccg ccaaacagat caagaccaag gtgaacaagc acgccttcag tggcggtcgt      720

gacacaatcg aggaacatcg ccagtttggt ggcaactgtg acgtggacgt gagcttcatg      780

tacctgacct tcttcctgga ggacgatgac aagctggagc aaatccgcaa ggactacaca      840

agtggcgcaa tgctgaccgg cgagttaaag aaagccctga tcgaggtgtt acagccgctg      900

atcgccgaac atcaagcccg tcgcaaagag gtgacagacg agatcgtgaa ggagttcatg      960

accccgcgca agctgagctt cgatttccag ctcgag                                996


<210>  218
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Leu Val Ser Leu Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp 
1               5                   10                  15      


Tyr Lys Ala Asp Cys Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His 
            20                  25                  30          


Gly Pro Asp Ala Thr Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr 
        35                  40                  45              


Val Gln Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val 
    50                  55                  60                  


Arg Phe Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu 
65                  70                  75                  80  


Arg Ala Thr Gly Gln Arg Pro His His Phe Leu Arg Arg Gly Ile Phe 
                85                  90                  95      


Phe Ser His Arg Asp Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys 
            100                 105                 110         


Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met 
        115                 120                 125             


His Val Gly His Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp 
    130                 135                 140                 


Val Phe Asn Val Pro Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr 
145                 150                 155                 160 


Leu Trp Lys Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu 
                165                 170                 175     


Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe 
            180                 185                 190         


Ile Phe Ser Asp Leu Asp Tyr Met Gly Glu Asp Gln Phe Ser Cys His 
        195                 200                 205             


Pro Gly Cys Ser Leu Leu Gln Gln Leu Ile Pro Thr Asp Leu Pro Arg 
    210                 215                 220                 


Gln Asp Gly Tyr Pro Val Pro Tyr Pro Met Cys His 
225                 230                 235     


<210>  219
<211>  711
<212>  DNA
<213>  Homo sapiens

<400>  219
atgttggtgt cattaaaaat gagctacaaa gctgccgcgg gggaggatta caaggctgac       60

tgtcctccag ggaacccagc acctaccagt aatcatggcc cagatgccac agaagctgaa      120

gaggattttg tggacccatg gacagtacag acaagcagtg caaaaggcat agactacgat      180

aagctcattg ttcggtttgg aagtagtaaa attgacaaag agctaataaa ccgaatagag      240

agagccaccg gccaaagacc acaccacttc ctgcgcagag gcatcttctt ctcacacaga      300

gatatgaatc aggttcttga tgcctatgaa aataagaagc cattttatct gtacacgggc      360

cggggcccct cttctgaagc aatgcatgta ggtcacctca ttccatttat tttcacaaag      420

tggctccagg atgtatttaa cgtgcccttg gtcatccaga tgacggatga cgagaagtat      480

ctgtggaagg acctgaccct ggaccaggcc tatagctatg ctgtggagaa tgccaaggac      540

atcatcgcct gtggctttga catcaacaag actttcatat tctctgacct ggactacatg      600

ggggaagatc agttttcctg ccatccaggc tgctccctcc ttcagcaact cattcccaca      660

gatcttccga gacaggacgg atatccagtg ccttatccca tgtgccattg a               711


<210>  220
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  220
tattctctga cctggactac atgggggaag atcagttttc ctgccatcca                  50


<210>  221
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  221

Phe Ser Asp Leu Asp Tyr Met Gly Glu Asp Gln Phe Ser Cys His Pro 
1               5                   10                  15      


<210>  222
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  222

Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys 
1               5                   10                  15      


Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg 
            20                  25                  30          


Pro His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met 
        35                  40                  45              


Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr 
    50                  55                  60                  


Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile 
65                  70                  75                  80  


Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu 
                85                  90                  95      


Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr 
            100                 105                 110         


Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile 
        115                 120                 125             


Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp 
    130                 135                 140                 


Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln 
145                 150                 155                 160 


Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp 
                165                 170                 175     


Ser Asp 
        


<210>  223
<211>  534
<212>  DNA
<213>  Homo sapiens

<400>  223
aaaggcatag actacgataa gctcattgtt cggtttggaa gtagtaaaat tgacaaagag       60

ctaataaacc gaatagagag agccaccggc caaagaccac accacttcct gcgcagaggc      120

atcttcttct cacacagaga tatgaatcag gttcttgatg cctatgaaaa taagaagcca      180

ttttatctgt acacgggccg gggcccctct tctgaagcaa tgcatgtagg tcacctcatt      240

ccatttattt tcacaaagtg gctccaggat gtatttaacg tgcccttggt catccagatg      300

acggatgacg agaagtatct gtggaaggac ctgaccctgg accaggccta tagctatgct      360

gtggagaatg ccaaggacat catcgcctgt ggctttgaca tcaacaagac tttcatattc      420

tctgacctgg actacatggg gatgagctca ggtttctaca aaaatgtggt gaagattcaa      480

aagcatgtta ccttcaacca agtgaaaggc attttcggct tcactgacag cgac            534


<210>  224
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with N-terminal 6xHis 
       affinity tag

<400>  224

Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu 
1               5                   10                  15      


Gly Leu Asp Ser Thr Gly Ser Leu Val Ser Leu Lys Met Ser Tyr Lys 
            20                  25                  30          


Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro Gly Asn Pro 
        35                  40                  45              


Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala Glu Glu Asp 
    50                  55                  60                  


Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys Gly Ile Asp 
65                  70                  75                  80  


Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile Asp Lys Glu 
                85                  90                  95      


Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro His His Phe 
            100                 105                 110         


Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn Gln Val Leu 
        115                 120                 125             


Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly 
    130                 135                 140                 


Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro Phe Ile Phe 
145                 150                 155                 160 


Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val Ile Gln Met 
                165                 170                 175     


Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu Asp Gln Ala 
            180                 185                 190         


Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe 
        195                 200                 205             


Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr Met Gly Glu 
    210                 215                 220                 


Asp Gln Phe Ser Cys His Pro Gly Cys Ser Leu Leu Gln Gln Leu Ile 
225                 230                 235                 240 


Pro Thr Asp Leu Pro Arg Gln Asp Gly Tyr Pro Val Pro Tyr Pro Met 
                245                 250                 255     


Cys His Leu Glu 
            260 


<210>  225
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with C-terminal 6xHis 
       affinity tag

<400>  225

Met Gly Ser Leu Val Ser Leu Lys Met Ser Tyr Lys Ala Ala Ala Gly 
1               5                   10                  15      


Glu Asp Tyr Lys Ala Asp Cys Pro Pro Gly Asn Pro Ala Pro Thr Ser 
            20                  25                  30          


Asn His Gly Pro Asp Ala Thr Glu Ala Glu Glu Asp Phe Val Asp Pro 
        35                  40                  45              


Trp Thr Val Gln Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu 
    50                  55                  60                  


Ile Val Arg Phe Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg 
65                  70                  75                  80  


Ile Glu Arg Ala Thr Gly Gln Arg Pro His His Phe Leu Arg Arg Gly 
                85                  90                  95      


Ile Phe Phe Ser His Arg Asp Met Asn Gln Val Leu Asp Ala Tyr Glu 
            100                 105                 110         


Asn Lys Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu 
        115                 120                 125             


Ala Met His Val Gly His Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu 
    130                 135                 140                 


Gln Asp Val Phe Asn Val Pro Leu Val Ile Gln Met Thr Asp Asp Glu 
145                 150                 155                 160 


Lys Tyr Leu Trp Lys Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala 
                165                 170                 175     


Val Glu Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys 
            180                 185                 190         


Thr Phe Ile Phe Ser Asp Leu Asp Tyr Met Gly Glu Asp Gln Phe Ser 
        195                 200                 205             


Cys His Pro Gly Cys Ser Leu Leu Gln Gln Leu Ile Pro Thr Asp Leu 
    210                 215                 220                 


Pro Arg Gln Asp Gly Tyr Pro Val Pro Tyr Pro Met Cys His Leu Glu 
225                 230                 235                 240 


Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His 
                245                 250                 255     


His His His His 
            260 


<210>  226
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with N-terminal 6xHis 
       affinity tag

<400>  226

Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu 
1               5                   10                  15      


Gly Leu Asp Ser Thr Gly Ser Lys Gly Ile Asp Tyr Asp Lys Leu Ile 
            20                  25                  30          


Val Arg Phe Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile 
        35                  40                  45              


Glu Arg Ala Thr Gly Gln Arg Pro His His Phe Leu Arg Arg Gly Ile 
    50                  55                  60                  


Phe Phe Ser His Arg Asp Met Asn Gln Val Leu Asp Ala Tyr Glu Asn 
65                  70                  75                  80  


Lys Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala 
                85                  90                  95      


Met His Val Gly His Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln 
            100                 105                 110         


Asp Val Phe Asn Val Pro Leu Val Ile Gln Met Thr Asp Asp Glu Lys 
        115                 120                 125             


Tyr Leu Trp Lys Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val 
    130                 135                 140                 


Glu Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr 
145                 150                 155                 160 


Phe Ile Phe Ser Asp Leu Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr 
                165                 170                 175     


Lys Asn Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys 
            180                 185                 190         


Gly Ile Phe Gly Phe Thr Asp Ser Asp Leu Glu 
        195                 200             


<210>  227
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptophanyl tRNA Synthetase polypeptide with C-terminal 6xHis 
       affinity tag

<400>  227

Met Gly Ser Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly 
1               5                   10                  15      


Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr 
            20                  25                  30          


Gly Gln Arg Pro His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His 
        35                  40                  45              


Arg Asp Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe 
    50                  55                  60                  


Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly 
65                  70                  75                  80  


His Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn 
                85                  90                  95      


Val Pro Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys 
            100                 105                 110         


Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys 
        115                 120                 125             


Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser 
    130                 135                 140                 


Asp Leu Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val 
145                 150                 155                 160 


Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly 
                165                 170                 175     


Phe Thr Asp Ser Asp Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu 
            180                 185                 190         


Gly Leu Asp Ser Thr His His His His His His 
        195                 200             


<210>  228
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized tryptophanyl tRNA synthetase polynucleotide

<400>  228
ggatccctgg ttagcctgaa gatgagctac aaagccgccg ccggcgaaga ctataaggca       60

gattgtcctc cgggcaaccc ggcccctacc agtaatcatg gtccggacgc cacagaagca      120

gaagaagact tcgtggaccc gtggaccgtg cagacaagca gcgccaaggg catcgactat      180

gacaagctga tcgtgcgctt tggcagcagc aagatcgaca aggagttaat caaccgcatc      240

gagcgcgcaa ccggccaacg cccgcatcac ttcctgcgtc gcggcatctt ctttagccac      300

cgcgatatga accaggtgct ggacgcctac gagaacaaaa agccgttcta cttatacacc      360

ggccgcggtc cgagcagcga agcaatgcac gtgggtcatc tgatcccgtt catcttcacc      420

aagtggctgc aggacgtgtt caacgtgccg ctggtgatcc aaatgaccga cgacgagaaa      480

tacctgtgga aggacctgac actggaccag gcctacagct acgccgtgga aaatgccaag      540

gacatcatcg cctgcggctt tgatattaac aagaccttca ttttcagcga cctggactac      600

atgggcgagg accagttcag ctgccacccg ggttgcagtc tgctgcagca gctgatcccg      660

acagacctgc cgcgtcagga cggttacccg gttccgtacc cgatgtgcca cctcgag         717


<210>  229
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized tryptophanyl tRNA synthetase polynucleotide

<400>  229
ggatccaagg gcatcgacta tgacaagctg atcgtgcgct ttggcagcag caagatcgac       60

aaggagttaa tcaaccgcat cgagcgcgca accggccaac gcccgcatca cttcctgcgt      120

cgcggcatct tctttagcca ccgcgatatg aaccaggtgc tggacgccta cgagaacaaa      180

aagccgttct acttatacac cggccgcggt ccgagcagcg aagcaatgca cgtgggtcat      240

ctgatcccgt tcatcttcac caagtggctg caggacgtgt tcaacgtgcc gctggtgatc      300

caaatgaccg acgacgagaa atacctgtgg aaggacctga cactggacca ggcctacagc      360

tacgccgtgg aaaatgccaa ggacatcatc gcctgcggct ttgatattaa caagaccttc      420

attttcagcg acctggacta catgggcatg agcagcggct tttataagaa cgtggtgaaa      480

attcaaaaac acgtgacatt caaccaggtg aaaggtatct tcggctttac cgacagcgac      540

ctcgag                                                                 546


<210>  230
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  230

Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys Gly Ile Asp 
1               5                   10                  15      


Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile Asp Lys Glu 
            20                  25                  30          


Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro His His Phe 
        35                  40                  45              


Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn Gln Val Leu 
    50                  55                  60                  


Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr Gly Arg Gly 
65                  70                  75                  80  


Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro Phe Ile Phe 
                85                  90                  95      


Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val Ile Gln Met 
            100                 105                 110         


Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu Asp Gln Ala 
        115                 120                 125             


Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala Cys Gly Phe 
    130                 135                 140                 


Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr Met Gly Met 
145                 150                 155                 160 


Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys His Val Thr 
                165                 170                 175     


Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser Asp Cys Ile 
            180                 185                 190         


Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser Phe Ser Asn 
        195                 200                 205             


Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln Cys Leu Ile 
    210                 215                 220                 


Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr Arg Asp Val 
225                 230                 235                 240 


Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His Ser Thr Phe 
                245                 250                 255     


Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala Ser Asp Pro 
            260                 265                 270         


Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile Lys Thr Lys 
        275                 280                 285             


Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile Glu Glu His 
    290                 295                 300                 


Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe Met Tyr Leu 
305                 310                 315                 320 


Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile Arg Lys Asp 
                325                 330                 335     


Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys Ala Leu Ile 
            340                 345                 350         


Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg Arg Lys Glu 
        355                 360                 365             


Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg Lys Leu Ser 
    370                 375                 380                 


Phe Asp Phe Gln 
385             


