                               SEQUENCE LISTING	

<110> THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
 
<120> PIWIL2-LIKE (PL2L) PROTEINS-TARGETED CANCER DIAGNOSIS AND THERAPY

<130> 53-52410

<140>
<141>

<150> 61/393,143
<151> 2010-10-14

<160> 34    

<170> PatentIn version 3.5

<210> 1
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 1
agagaagcag cagatgttgg agca                                              24


<210> 2
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 2
atcctgcatg tctccttggc tctt                                              24


<210> 3
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 3
ttgtggcctt ctttgagttc ggtg                                              24


<210> 4
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 4
aatcaaacag aggtcgcatg ctgg                                              24


<210> 5
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
actgtgcgtg gaaagcgtag acaa                                              24


<210> 6
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
ctgcattgtt cccgtagaga tccaca                                            26


<210> 7
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
tgaaccctaa ggccaaccgt gaaa                                              24


<210> 8
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
gagtccatca caatgcctgt ggta                                              24


<210> 9
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
aataggaggg aaaggaggtg gct                                               23


<210> 10
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
tggtggtcct tcaacatgcc aaac                                              24


<210> 11
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
tcctcagtct ttgggactga acct                                              24


<210> 12
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
gacatcttta tgcagactga gccc                                              24


<210> 13
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
agatgaagaa ggacttcagg gcca                                              24


<210> 14
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
gaactacaaa caccaccatc ttggg                                             25


<210> 15
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
ttgtggtgta ccgagatgga gtgt                                              24


<210> 16
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
cagcggctac ctacaaactt gctt                                              24


<210> 17
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
tgaactgtaa actgggtggt gagc                                              24


<210> 18
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
cactcacagc tggttatggt atga                                              24


<210> 19
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
ttcggagtgt ggcccagaag attt                                              24


<210> 20
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
acagttccag gagtgggagt taca                                              24


<210> 21
<211> 973
<212> PRT
<213> Homo sapiens

<400> 21
Met Asp Pro Phe Arg Pro Ser Phe Arg Gly Gln Ser Pro Ile His Pro 
1               5                   10                  15      


Ser Gln Cys Gln Ala Val Arg Met Pro Gly Cys Trp Pro Gln Ala Ser 
            20                  25                  30          


Lys Pro Leu Asp Pro Ala Leu Gly Arg Gly Ala Pro Ala Gly Arg Gly 
        35                  40                  45              


His Val Phe Gly Lys Pro Glu Glu Pro Ser Thr Gln Arg Gly Pro Ala 
    50                  55                  60                  


Gln Arg Glu Ser Val Gly Leu Val Ser Met Phe Arg Gly Leu Gly Ile 
65                  70                  75                  80  


Glu Thr Val Ser Lys Thr Pro Leu Lys Arg Glu Met Leu Pro Ser Gly 
                85                  90                  95      


Arg Gly Ile Leu Gly Arg Gly Leu Ser Ala Asn Leu Val Arg Lys Asp 
            100                 105                 110         


Arg Glu Glu Leu Ser Pro Thr Phe Trp Asp Pro Lys Val Leu Ala Ala 
        115                 120                 125             


Gly Asp Ser Lys Met Ala Glu Thr Ser Val Gly Trp Ser Arg Thr Leu 
    130                 135                 140                 


Gly Arg Gly Ser Ser Asp Ala Ser Leu Leu Pro Leu Gly Arg Ala Ala 
145                 150                 155                 160 


Gly Gly Ile Ser Arg Glu Val Asp Lys Pro Pro Cys Thr Phe Ser Thr 
                165                 170                 175     


Pro Ser Arg Gly Pro Pro Gln Leu Ser Ser Pro Pro Ala Leu Pro Gln 
            180                 185                 190         


Ser Pro Leu His Ser Pro Asp Arg Pro Leu Val Leu Thr Val Glu His 
        195                 200                 205             


Lys Glu Lys Glu Leu Ile Val Lys Gln Gly Ser Lys Gly Thr Pro Gln 
    210                 215                 220                 


Ser Leu Gly Leu Asn Leu Val Lys Ile Gln Cys His Asn Glu Ala Val 
225                 230                 235                 240 


Tyr Gln Tyr His Val Thr Phe Ser Pro Asn Val Glu Cys Lys Ser Met 
                245                 250                 255     


Arg Phe Gly Met Leu Lys Asp His Gln Ala Val Thr Gly Asn Val Thr 
            260                 265                 270         


Ala Phe Asp Gly Ser Ile Leu Tyr Leu Pro Val Lys Leu Gln Gln Val 
        275                 280                 285             


Leu Glu Leu Lys Ser Gln Arg Lys Thr Asp Ser Ala Glu Ile Ser Ile 
    290                 295                 300                 


Lys Ile Gln Met Thr Lys Ile Leu Glu Pro Cys Ser Asp Leu Cys Ile 
305                 310                 315                 320 


Pro Phe Tyr Asn Val Val Phe Arg Arg Val Met Lys Leu Leu Asp Met 
                325                 330                 335     


Lys Leu Val Gly Arg Asn Phe Tyr Asp Pro Thr Ser Ala Met Val Leu 
            340                 345                 350         


Gln Gln His Arg Leu Gln Ile Trp Pro Gly Tyr Ala Ala Ser Ile Arg 
        355                 360                 365             


Arg Thr Asp Gly Gly Leu Phe Leu Leu Ala Asp Val Ser His Lys Val 
    370                 375                 380                 


Ile Arg Asn Asp Cys Val Leu Asp Val Met His Ala Ile Tyr Gln Gln 
385                 390                 395                 400 


Asn Lys Glu His Phe Gln Asp Glu Cys Thr Lys Leu Leu Val Gly Asn 
                405                 410                 415     


Ile Val Ile Thr Arg Tyr Asn Asn Arg Thr Tyr Arg Ile Asp Asp Val 
            420                 425                 430         


Asp Trp Asn Lys Thr Pro Lys Asp Ser Phe Thr Met Ser Asp Gly Lys 
        435                 440                 445             


Glu Ile Thr Phe Leu Glu Tyr Tyr Ser Lys Asn Tyr Gly Ile Thr Val 
    450                 455                 460                 


Lys Glu Glu Asp Gln Pro Leu Leu Ile His Arg Pro Ser Glu Arg Gln 
465                 470                 475                 480 


Asp Asn His Gly Met Leu Leu Lys Gly Glu Ile Leu Leu Leu Pro Glu 
                485                 490                 495     


Leu Ser Phe Met Thr Gly Ile Pro Glu Lys Met Lys Lys Asp Phe Arg 
            500                 505                 510         


Ala Met Lys Asp Leu Ala Gln Gln Ile Asn Leu Ser Pro Lys Gln His 
        515                 520                 525             


His Ser Ala Leu Glu Cys Leu Leu Gln Arg Ile Ala Lys Asn Glu Ala 
    530                 535                 540                 


Ala Thr Asn Glu Leu Met Arg Trp Gly Leu Arg Leu Gln Lys Asp Val 
545                 550                 555                 560 


His Lys Ile Glu Gly Arg Val Leu Pro Met Glu Arg Ile Asn Leu Lys 
                565                 570                 575     


Asn Thr Ser Phe Ile Thr Ser Gln Glu Leu Asn Trp Val Lys Glu Val 
            580                 585                 590         


Thr Arg Asp Pro Ser Ile Leu Thr Ile Pro Met His Phe Trp Ala Leu 
        595                 600                 605             


Phe Tyr Pro Lys Arg Ala Met Asp Gln Ala Arg Glu Leu Val Asn Met 
    610                 615                 620                 


Leu Glu Lys Ile Ala Gly Pro Ile Gly Met Arg Met Ser Pro Pro Ala 
625                 630                 635                 640 


Trp Val Glu Leu Lys Asp Asp Arg Ile Glu Thr Tyr Val Arg Thr Ile 
                645                 650                 655     


Gln Ser Thr Leu Gly Ala Glu Gly Lys Ile Gln Met Val Val Cys Ile 
            660                 665                 670         


Ile Met Gly Pro Arg Asp Asp Leu Tyr Gly Ala Ile Lys Lys Leu Cys 
        675                 680                 685             


Cys Val Gln Ser Pro Val Pro Ser Gln Val Val Asn Val Arg Thr Ile 
    690                 695                 700                 


Gly Gln Pro Thr Arg Leu Arg Ser Val Ala Gln Lys Ile Leu Leu Gln 
705                 710                 715                 720 


Ile Asn Cys Lys Leu Gly Gly Glu Leu Trp Gly Val Asp Ile Pro Leu 
                725                 730                 735     


Lys Gln Leu Met Val Ile Gly Met Asp Val Tyr His Asp Pro Ser Arg 
            740                 745                 750         


Gly Met Arg Ser Val Val Gly Phe Val Ala Ser Ile Asn Leu Thr Leu 
        755                 760                 765             


Thr Lys Trp Tyr Ser Arg Val Val Phe Gln Met Pro His Gln Glu Ile 
    770                 775                 780                 


Val Asp Ser Leu Lys Leu Cys Leu Val Gly Ser Leu Lys Lys Phe Tyr 
785                 790                 795                 800 


Glu Val Asn His Cys Leu Pro Glu Lys Ile Val Val Tyr Arg Asp Gly 
                805                 810                 815     


Val Ser Asp Gly Gln Leu Lys Thr Val Ala Asn Tyr Glu Ile Pro Gln 
            820                 825                 830         


Leu Gln Lys Cys Phe Glu Ala Phe Glu Asn Tyr Gln Pro Lys Met Val 
        835                 840                 845             


Val Phe Val Val Gln Lys Lys Ile Ser Thr Asn Leu Tyr Leu Ala Ala 
    850                 855                 860                 


Pro Gln Asn Phe Val Thr Pro Thr Pro Gly Thr Val Val Asp His Thr 
865                 870                 875                 880 


Ile Thr Ser Cys Glu Trp Val Asp Phe Tyr Leu Leu Ala His His Val 
                885                 890                 895     


Arg Gln Gly Cys Gly Ile Pro Thr His Tyr Val Cys Val Leu Asn Thr 
            900                 905                 910         


Ala Asn Leu Ser Pro Asp His Met Gln Arg Leu Thr Phe Lys Leu Cys 
        915                 920                 925             


His Met Tyr Trp Asn Trp Pro Gly Thr Ile Arg Val Pro Ala Pro Cys 
    930                 935                 940                 


Lys Tyr Ala His Lys Leu Ala Phe Leu Ser Gly His Ile Leu His His 
945                 950                 955                 960 


Glu Pro Ala Ile Gln Leu Cys Glu Asn Leu Phe Phe Leu 
                965                 970             


<210> 22
<211> 971
<212> PRT
<213> Mus sp.

<400> 22
Met Asp Pro Val Arg Pro Leu Phe Arg Gly Pro Thr Pro Val His Pro 
1               5                   10                  15      


Ser Gln Cys Val Arg Met Pro Gly Cys Trp Pro Gln Ala Pro Arg Pro 
            20                  25                  30          


Leu Glu Pro Ala Trp Gly Arg Ala Gly Pro Ala Gly Arg Gly Leu Val 
        35                  40                  45              


Phe Arg Lys Pro Glu Asp Ser Ser Pro Pro Leu Gln Pro Val Gln Lys 
    50                  55                  60                  


Asp Ser Val Gly Leu Val Ser Met Phe Arg Gly Met Gly Leu Asp Thr 
65                  70                  75                  80  


Ala Phe Arg Pro Pro Ser Lys Arg Glu Val Pro Pro Leu Gly Arg Gly 
                85                  90                  95      


Val Leu Gly Arg Gly Leu Ser Ala Asn Met Val Arg Lys Asp Arg Glu 
            100                 105                 110         


Glu Pro Arg Ser Ser Leu Pro Asp Pro Ser Val Leu Ala Ala Gly Asp 
        115                 120                 125             


Ser Lys Leu Ala Glu Ala Ser Val Gly Trp Ser Arg Met Leu Gly Arg 
    130                 135                 140                 


Gly Ser Ser Glu Val Ser Leu Leu Pro Leu Gly Arg Ala Ala Ser Ser 
145                 150                 155                 160 


Ile Gly Arg Gly Met Asp Lys Pro Pro Ser Ala Phe Gly Leu Thr Ala 
                165                 170                 175     


Arg Asp Pro Pro Arg Leu Pro Gln Pro Pro Ala Leu Ser Pro Thr Ser 
            180                 185                 190         


Leu His Ser Ala Asp Pro Pro Pro Val Leu Thr Met Glu Arg Lys Glu 
        195                 200                 205             


Lys Glu Leu Leu Val Lys Gln Gly Ser Lys Gly Thr Pro Gln Ser Leu 
    210                 215                 220                 


Gly Leu Asn Leu Ile Lys Ile Gln Cys His Asn Glu Ala Val Tyr Gln 
225                 230                 235                 240 


Tyr His Val Thr Phe Ser Pro Ser Val Glu Cys Lys Ser Met Arg Phe 
                245                 250                 255     


Gly Met Leu Lys Asp His Gln Ser Val Thr Gly Asn Val Thr Ala Phe 
            260                 265                 270         


Asp Gly Ser Ile Leu Tyr Leu Pro Val Lys Leu Gln Gln Val Val Glu 
        275                 280                 285             


Leu Lys Ser Gln Arg Lys Thr Asp Asp Ala Glu Ile Ser Ile Lys Ile 
    290                 295                 300                 


Gln Leu Thr Lys Ile Leu Glu Pro Cys Ser Asp Leu Cys Ile Pro Phe 
305                 310                 315                 320 


Tyr Asn Val Val Phe Arg Arg Val Met Lys Leu Leu Asp Met Lys Leu 
                325                 330                 335     


Val Gly Arg Asn Phe Tyr Asp Pro Thr Ser Ala Met Val Leu Gln Gln 
            340                 345                 350         


His Arg Leu Gln Ile Trp Pro Gly Tyr Ala Ala Ser Ile Arg Arg Thr 
        355                 360                 365             


Asp Gly Gly Leu Phe Leu Leu Ala Asp Val Ser His Lys Val Ile Arg 
    370                 375                 380                 


Asn Asp Ser Val Leu Asp Val Met His Ala Ile Tyr Gln Gln Asn Lys 
385                 390                 395                 400 


Glu His Phe Gln Asp Glu Cys Ser Lys Leu Leu Val Gly Ser Ile Val 
                405                 410                 415     


Ile Thr Arg Tyr Asn Asn Arg Thr Tyr Arg Ile Asp Asp Val Asp Trp 
            420                 425                 430         


Asn Lys Thr Pro Lys Asp Ser Phe Val Met Ser Asp Gly Lys Glu Ile 
        435                 440                 445             


Thr Phe Leu Glu Tyr Tyr Ser Lys Asn Tyr Gly Ile Thr Val Lys Glu 
    450                 455                 460                 


Asp Asp Gln Pro Leu Leu Ile His Arg Pro Ser Glu Arg Gln Asn Asn 
465                 470                 475                 480 


His Gly Met Leu Leu Lys Gly Glu Ile Leu Leu Leu Pro Glu Leu Ser 
                485                 490                 495     


Phe Met Thr Gly Ile Pro Glu Lys Met Lys Lys Asp Phe Arg Ala Met 
            500                 505                 510         


Lys Asp Leu Thr Gln Gln Ile Asn Leu Ser Pro Lys Gln His His Gly 
        515                 520                 525             


Ala Leu Glu Cys Leu Leu Gln Arg Ile Ser Gln Asn Glu Thr Ala Ser 
    530                 535                 540                 


Asn Glu Leu Thr Arg Trp Gly Leu Ser Leu His Lys Asp Val His Lys 
545                 550                 555                 560 


Ile Glu Gly Arg Leu Leu Pro Met Glu Arg Ile Asn Leu Arg Asn Thr 
                565                 570                 575     


Ser Phe Val Thr Ser Glu Asp Leu Asn Trp Val Lys Glu Val Thr Arg 
            580                 585                 590         


Asp Ala Ser Ile Leu Thr Ile Pro Met His Phe Trp Ala Leu Phe Tyr 
        595                 600                 605             


Pro Lys Arg Ala Met Asp Gln Ala Arg Glu Leu Val Asn Met Leu Glu 
    610                 615                 620                 


Lys Ile Ala Gly Pro Ile Gly Met Arg Ile Ser Pro Pro Ala Trp Val 
625                 630                 635                 640 


Glu Leu Lys Asp Asp Arg Ile Glu Thr Tyr Ile Arg Thr Ile Gln Ser 
                645                 650                 655     


Leu Leu Gly Val Glu Gly Lys Ile Gln Met Val Val Cys Ile Ile Met 
            660                 665                 670         


Gly Thr Arg Asp Asp Leu Tyr Gly Ala Ile Lys Lys Leu Cys Cys Val 
        675                 680                 685             


Gln Ser Pro Val Pro Ser Gln Val Ile Asn Val Arg Thr Ile Gly Gln 
    690                 695                 700                 


Pro Thr Arg Leu Arg Ser Val Ala Gln Lys Ile Leu Leu Gln Met Asn 
705                 710                 715                 720 


Cys Lys Leu Gly Gly Glu Leu Trp Gly Val Asp Ile Pro Leu Lys Gln 
                725                 730                 735     


Leu Met Val Ile Gly Met Asp Val Tyr His Asp Pro Ser Arg Gly Met 
            740                 745                 750         


Arg Ser Val Val Gly Phe Val Ala Ser Ile Asn Leu Thr Leu Thr Lys 
        755                 760                 765             


Trp Tyr Ser Arg Val Val Phe Gln Met Pro His Gln Glu Ile Val Asp 
    770                 775                 780                 


Ser Leu Lys Leu Cys Leu Val Gly Ser Leu Lys Lys Tyr Tyr Glu Val 
785                 790                 795                 800 


Asn His Cys Leu Pro Glu Lys Ile Val Val Tyr Arg Asp Gly Val Ser 
                805                 810                 815     


Asp Gly Gln Leu Lys Thr Val Ala Asn Tyr Glu Ile Pro Gln Leu Gln 
            820                 825                 830         


Lys Cys Phe Glu Ala Phe Asp Asn Tyr His Pro Lys Met Val Val Phe 
        835                 840                 845             


Val Val Gln Lys Lys Ile Ser Thr Asn Leu Tyr Leu Ala Ala Pro Asp 
    850                 855                 860                 


His Phe Val Thr Pro Ser Pro Gly Thr Val Val Asp His Thr Ile Thr 
865                 870                 875                 880 


Ser Cys Glu Trp Val Asp Phe Tyr Leu Leu Ala His His Val Arg Gln 
                885                 890                 895     


Gly Cys Gly Ile Pro Thr His Tyr Ile Cys Val Leu Asn Thr Ala Asn 
            900                 905                 910         


Leu Ser Pro Asp His Met Gln Arg Leu Thr Phe Lys Leu Cys His Met 
        915                 920                 925             


Tyr Trp Asn Trp Pro Gly Thr Ile Arg Val Pro Ala Pro Cys Lys Tyr 
    930                 935                 940                 


Ala His Lys Leu Ala Phe Leu Ser Gly Gln Ile Leu His His Glu Pro 
945                 950                 955                 960 


Ala Ile Gln Leu Cys Gly Asn Leu Phe Phe Leu 
                965                 970     


<210> 23
<211> 530
<212> PRT
<213> Homo sapiens

<400> 23
Met Ser Asp Gly Lys Glu Ile Thr Phe Leu Glu Tyr Tyr Ser Lys Asn 
1               5                   10                  15      


Tyr Gly Ile Thr Val Lys Glu Glu Asp Gln Pro Leu Leu Ile His Arg 
            20                  25                  30          


Pro Ser Glu Arg Gln Asp Asn His Gly Met Leu Leu Lys Gly Glu Ile 
        35                  40                  45              


Leu Leu Leu Pro Glu Leu Ser Phe Met Thr Gly Ile Pro Glu Lys Met 
    50                  55                  60                  


Lys Lys Asp Phe Arg Ala Met Lys Asp Leu Ala Gln Gln Ile Asn Leu 
65                  70                  75                  80  


Ser Pro Lys Gln His His Ser Ala Leu Glu Cys Leu Leu Gln Arg Ile 
                85                  90                  95      


Ala Lys Asn Glu Ala Ala Thr Asn Glu Leu Met Arg Trp Gly Leu Arg 
            100                 105                 110         


Leu Gln Lys Asp Val His Lys Ile Glu Gly Arg Val Leu Pro Met Glu 
        115                 120                 125             


Arg Ile Asn Leu Lys Asn Thr Ser Phe Ile Thr Ser Gln Glu Leu Asn 
    130                 135                 140                 


Trp Val Lys Glu Val Thr Arg Asp Pro Ser Ile Leu Thr Ile Pro Met 
145                 150                 155                 160 


His Phe Trp Ala Leu Phe Tyr Pro Lys Arg Ala Met Asp Gln Ala Arg 
                165                 170                 175     


Glu Leu Val Asn Met Leu Glu Lys Ile Ala Gly Pro Ile Gly Met Arg 
            180                 185                 190         


Met Ser Pro Pro Ala Trp Val Glu Leu Lys Asp Asp Arg Ile Glu Thr 
        195                 200                 205             


Tyr Val Arg Thr Ile Gln Ser Thr Leu Gly Ala Glu Gly Lys Ile Gln 
    210                 215                 220                 


Met Val Val Cys Ile Ile Met Gly Pro Arg Asp Asp Leu Tyr Gly Ala 
225                 230                 235                 240 


Ile Lys Lys Leu Cys Cys Val Gln Ser Pro Val Pro Ser Gln Val Val 
                245                 250                 255     


Asn Val Arg Thr Ile Gly Gln Pro Thr Arg Leu Arg Ser Val Ala Gln 
            260                 265                 270         


Lys Ile Leu Leu Gln Ile Asn Cys Lys Leu Gly Gly Glu Leu Trp Gly 
        275                 280                 285             


Val Asp Ile Pro Leu Lys Gln Leu Met Val Ile Gly Met Asp Val Tyr 
    290                 295                 300                 


His Asp Pro Ser Arg Gly Met Arg Ser Val Val Gly Phe Val Ala Ser 
305                 310                 315                 320 


Ile Asn Leu Thr Leu Thr Lys Trp Tyr Ser Arg Val Val Phe Gln Met 
                325                 330                 335     


Pro His Gln Glu Ile Val Asp Ser Leu Lys Leu Cys Leu Val Gly Ser 
            340                 345                 350         


Leu Lys Lys Phe Tyr Glu Val Asn His Cys Leu Pro Glu Lys Ile Val 
        355                 360                 365             


Val Tyr Arg Asp Gly Val Ser Asp Gly Gln Leu Lys Thr Val Ala Asn 
    370                 375                 380                 


Tyr Glu Ile Pro Gln Leu Gln Lys Cys Phe Glu Ala Phe Glu Asn Tyr 
385                 390                 395                 400 


Gln Pro Lys Met Val Val Phe Val Val Gln Lys Lys Ile Ser Thr Asn 
                405                 410                 415     


Leu Tyr Leu Ala Ala Pro Gln Asn Phe Val Thr Pro Thr Pro Gly Thr 
            420                 425                 430         


Val Val Asp His Thr Ile Thr Ser Cys Glu Trp Val Asp Phe Tyr Leu 
        435                 440                 445             


Leu Ala His His Val Arg Gln Gly Cys Gly Ile Pro Thr His Tyr Val 
    450                 455                 460                 


Cys Val Leu Asn Thr Ala Asn Leu Ser Pro Asp His Met Gln Arg Leu 
465                 470                 475                 480 


Thr Phe Lys Leu Cys His Met Tyr Trp Asn Trp Pro Gly Thr Ile Arg 
                485                 490                 495     


Val Pro Ala Pro Cys Lys Tyr Ala His Lys Leu Ala Phe Leu Ser Gly 
            500                 505                 510         


His Ile Leu His His Glu Pro Ala Ile Gln Leu Cys Glu Asn Leu Phe 
        515                 520                 525             


Phe Leu 
    530 


<210> 24
<211> 118
<212> PRT
<213> Homo sapiens

<400> 24
Asn Asp Cys Val Leu Asp Val Met His Ala Ile Tyr Gln Gln Asn Lys 
1               5                   10                  15      


Glu His Phe Gln Asp Glu Cys Thr Lys Leu Leu Val Gly Asn Ile Val 
            20                  25                  30          


Ile Thr Arg Tyr Asn Asn Arg Thr Tyr Arg Ile Asp Asp Val Asp Trp 
        35                  40                  45              


Asn Lys Thr Pro Lys Asp Ser Phe Thr Met Ser Asp Gly Lys Glu Ile 
    50                  55                  60                  


Thr Phe Leu Glu Tyr Tyr Ser Lys Asn Tyr Gly Ile Thr Val Lys Glu 
65                  70                  75                  80  


Glu Asp Gln Pro Leu Leu Ile His Arg Pro Ser Glu Arg Gln Asp Asn 
                85                  90                  95      


His Gly Met Leu Leu Lys Gly Glu Ile Leu Leu Leu Pro Glu Leu Ser 
            100                 105                 110         


Phe Met Thr Gly Ile Pro 
        115             


<210> 25
<211> 445
<212> PRT
<213> Homo sapiens

<400> 25
Arg Ala Met Lys Asp Leu Ala Gln Gln Ile Asn Leu Ser Pro Lys Gln 
1               5                   10                  15      


His His Ser Ala Leu Glu Cys Leu Leu Gln Arg Ile Ala Lys Asn Glu 
            20                  25                  30          


Ala Ala Thr Asn Glu Leu Met Arg Trp Gly Leu Arg Leu Gln Lys Asp 
        35                  40                  45              


Val His Lys Ile Glu Gly Arg Val Leu Pro Met Glu Arg Ile Asn Leu 
    50                  55                  60                  


Lys Asn Thr Ser Phe Ile Thr Ser Gln Glu Leu Asn Trp Val Lys Glu 
65                  70                  75                  80  


Val Thr Arg Asp Pro Ser Ile Leu Thr Ile Pro Met His Phe Trp Ala 
                85                  90                  95      


Leu Phe Tyr Pro Lys Arg Ala Met Asp Gln Ala Arg Glu Leu Val Asn 
            100                 105                 110         


Met Leu Glu Lys Ile Ala Gly Pro Ile Gly Met Arg Met Ser Pro Pro 
        115                 120                 125             


Ala Trp Val Glu Leu Lys Asp Asp Arg Ile Glu Thr Tyr Val Arg Thr 
    130                 135                 140                 


Ile Gln Ser Thr Leu Gly Ala Glu Gly Lys Ile Gln Met Val Val Cys 
145                 150                 155                 160 


Ile Ile Met Gly Pro Arg Asp Asp Leu Tyr Gly Ala Ile Lys Lys Leu 
                165                 170                 175     


Cys Cys Val Gln Ser Pro Val Pro Ser Gln Val Val Asn Val Arg Thr 
            180                 185                 190         


Ile Gly Gln Pro Thr Arg Leu Arg Ser Val Ala Gln Lys Ile Leu Leu 
        195                 200                 205             


Gln Ile Asn Cys Lys Leu Gly Gly Glu Leu Trp Gly Val Asp Ile Pro 
    210                 215                 220                 


Leu Lys Gln Leu Met Val Ile Gly Met Asp Val Tyr His Asp Pro Ser 
225                 230                 235                 240 


Arg Gly Met Arg Ser Val Val Gly Phe Val Ala Ser Ile Asn Leu Thr 
                245                 250                 255     


Leu Thr Lys Trp Tyr Ser Arg Val Val Phe Gln Met Pro His Gln Glu 
            260                 265                 270         


Ile Val Asp Ser Leu Lys Leu Cys Leu Val Gly Ser Leu Lys Lys Phe 
        275                 280                 285             


Tyr Glu Val Asn His Cys Leu Pro Glu Lys Ile Val Val Tyr Arg Asp 
    290                 295                 300                 


Gly Val Ser Asp Gly Gln Leu Lys Thr Val Ala Asn Tyr Glu Ile Pro 
305                 310                 315                 320 


Gln Leu Gln Lys Cys Phe Glu Ala Phe Glu Asn Tyr Gln Pro Lys Met 
                325                 330                 335     


Val Val Phe Val Val Gln Lys Lys Ile Ser Thr Asn Leu Tyr Leu Ala 
            340                 345                 350         


Ala Pro Gln Asn Phe Val Thr Pro Thr Pro Gly Thr Val Val Asp His 
        355                 360                 365             


Thr Ile Thr Ser Cys Glu Trp Val Asp Phe Tyr Leu Leu Ala His His 
    370                 375                 380                 


Val Arg Gln Gly Cys Gly Ile Pro Thr His Tyr Val Cys Val Leu Asn 
385                 390                 395                 400 


Thr Ala Asn Leu Ser Pro Asp His Met Gln Arg Leu Thr Phe Lys Leu 
                405                 410                 415     


Cys His Met Tyr Trp Asn Trp Pro Gly Thr Ile Arg Val Pro Ala Pro 
            420                 425                 430         


Cys Lys Tyr Ala His Lys Leu Ala Phe Leu Ser Gly His 
        435                 440                 445 


<210> 26
<211> 21
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: PL2L peptide Pa sequence

<400> 26
Cys Phe Tyr Pro Lys Arg Ala Met Asp Gln Ala Arg Glu Leu Val Asn 
1               5                   10                  15      


Met Leu Glu Lys Ile 
            20      


<210> 27
<211> 15
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: PL2L peptide Pb sequence

<400> 27
Ile Pro Glu Lys Met Lys Lys Asp Phe Arg Ala Met Lys Asp Leu 
1               5                   10                  15  


<210> 28
<211> 15
<212> PRT
<213> Homo sapiens

<400> 28
Ile Pro Glu Lys Met Lys Lys Asp Phe Arg Ala Met Lys Asp Leu 
1               5                   10                  15  


<210> 29
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
ucguaccuac cgaaucgau                                                    19


<210> 30
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
cacgugagga ucaccauca                                                    19


<210> 31
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
cuaugagauu ccucaacuac agaag                                             25


<210> 32
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
cuucuguagu ugaggaaucu cauaguu                                           27


<210> 33
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
gcggatccac catggctgat gggaaagaga tcacattct                              39


<210> 34
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
gagaattcac aggaagaaca ggttctcg                                          28


