
                                SEQUENCE LISTING

<110> Merck Sharp & Dohme Corp.
      Colletti, Stephen L.
      Stanton, Matthew G.
      
 
<120> NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR
  OLIGONUCLEOTIDE DELIVERY
  

<130> MRL-MIS-00046

<150> US 61/405,413
<150> 2010-10-21

<160> 4

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Enzymatic Nucleic Acid

<221> misc_feature   
<222> (1)...(1)
<223> 2'-deoxy

<221> misc_feature   
<222> (2)...(2)
<223> 2'-fluoro

<221> misc_feature   
<222> (3)...(6)
<223> 2'-deoxy

<221> misc_feature   
<222> (7)...(8)
<223> 2'-fluoro

<221> misc_feature   
<222> (9)...(9)
<223> 2'-deoxy

<221> misc_feature   
<222> (10)...(10)
<223> 2'-fluoro

<221> misc_feature   
<222> (11)...(17)
<223> 2'-deoxy

<221> misc_feature   
<222> (18)...(18)
<223> 2'-fluoro

<221> misc_feature   
<222> (19)...(21)
<223> 2'-deoxy

<400> 1
auaaggcuau gaagagauat t                                           21

<210> 2
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Enzymatic Nucleic Acid

<221> misc_feature   
<222> (1)...(3)
<223> ribose

<221> misc_feature   
<222> (4)...(9)
<223> 2'-fluoro

<221> misc_feature   
<222> (10)...(10)
<223> 2'-o-methyl

<221> misc_feature   
<222> (11)...(11)
<223> 2'-fluoro

<221> misc_feature   
<222> (12)...(13)
<223> 2'-o-methyl

<221> misc_feature   
<222> (14)...(17)
<223> 2'-fluoro

<221> misc_feature   
<222> (18)...(18)
<223> 2'-o-methyl

<221> misc_feature   
<222> (19)...(19)
<223> 2'-fluoro

<221> misc_feature   
<222> (20)...(21)
<223> 2'-o-methyl

<400> 2
uuuauuccga uacuucucua u                                           21

<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  amino linker

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted deoxy abasic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted deoxy abasic

<400>  3
cuagcuggac acgucgauat t                                                 21

<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  4
uaucgacgug uccagcuagu u                                                 21


