
                         SEQUENCE LISTING

<110>  Danisco A/S
 
<120>  LACTOCOCCUS CRISPR/cas SEQUENCES

<130>  P042296USO

<160>  60    

<170>  PatentIn version 3.3

<210>  1
<211>  9873
<212>  DNA
<213>  Lactococcus lactis

<400>  1
tcgtgcgctt tctaattctt agtggtttaa gactaggata gcacgactta tatatttttc     60

aatgaaatca actagcaatt cgggtttata atgtgtttat ttatggaaaa aattatcatt    120

aaaaatcaag aaaatagttg gcaaacaaga ttgtttaacg taaaataata tcctttacca    180

aaaaaggtag aaagaatttt atggacaaaa taaatttagt atgtggttca cttttacacg    240

atattggaaa aattatttat cgtggtacta gcgaacgagc aaagcactct aaacttggtg    300

gagatttcat caaatccttt gagcaattta gaaatacaga attgactgat tgtatccgat    360

atcatcatgc ccaagaaatc acatctgtga aatcaaataa ggaaaaaaac tcactgtttt    420

atataactta tatcgctgat aacatttcat cgggtatgga tagacgaaaa gatttggaag    480

aaggtgcaga aggatttaat tgggataaaa aagttgcgct tggtagtgtt tttaatgtac    540

tgaacgaaaa agaaaaggga cggcaaaact attcatatcc gtttgtggca agaacacgga    600

taaaagaaga gccactaaat tttccaactg ctactcaaaa tcagtataca acttcctatt    660

atgacggttt aattactgat atgaaaacga ttttacagcg acttaagcca gataaggaac    720

acatcaactc tttgctgcaa atgatggaaa gtctgtggtc ttacgtccca agttcgactg    780

ataaaaatca gttggttgat atttctcttt acgaccattc gagaacgact gcggcgattg    840

caagtgctat ttatgactat tttcaggcag aaaatatcac tgattatcaa aaagaattat    900

ttgattataa tgctacggaa ttttatgata aaaatgcctt tttgatgatg aattttgata    960

tgagcggtgt tcagaatttt atttataata tttctggtag taaagctttg aaatcgttac   1020

gagcgcgaag tttttatctg gatatgttgt tggaatatat ttctgataat ttactcgaaa   1080

aactggaatt atctcgtgct aatattctat atgttggtgg cggtcatgcc tatcttttat   1140

tagccaatac gaacaaaact aaggctattt tatctgattt tgagcatgac ttaaaaacat   1200

ggtttttgga taaattcaag atagatttgt atgttgcaat ggcttataca gaagtttctg   1260

ctaatgactt gatgaatcat aatggtcatt accgtgatat ttatcgtcgt ttatcccaaa   1320

aaacatcagc taagaaagct aaccgctata ctgctgaaga aattttaaat ttaaaccatc   1380

aaggtacgga aaatgctcgt gagtgtcgcg aatgtaaacg aagtgattta ttgatagaag   1440

aagatgatat ttgtgaaatt tgtgatagtc tacaaaaagt ttcgagagat ttgacaagag   1500

aaaatatttt tgtgattgca aatgaaggag tgcttgacat gccttttggt aaaaagatgt   1560

ctgcactatc ttatagtcaa gctgataagc taaagaaaag caatgccgaa gttcaaattt   1620

atgccaagaa catctctgaa attggacaaa atttgatgac acgaattgat atgggagatt   1680

atacttatcg ttcagacttt catgaaatgt tagaagaagt tgaagtaggc atcaatcgtc   1740

taggcgtact tcgagcagat gttgataatc ttggtcaagc ctttattaac ggtattccag   1800

atgactattt gtcaatctct agaaccgcaa cattctcacg tgccatgagt agatttttca   1860

aaaattatct caatcaactt ttggctgaga aaagctataa aatcaacgtt atttatgctg   1920

gcggtgatga cttattcatg attggcgctt ggcaagatat tttagatttt tcgattgtgc   1980

ttaagcaaaa gtttgctgac tttacacaaa ataaattgtc gatttctgca ggtattggca   2040

tgttcagaga aaaatatcct gtggctagaa tggcaagtct gacaggagat ttagaggacg   2100

cagcaaagga ctataagcct gatgaaagag ctgtccaagc aacaaaaaat gcggtgacat   2160

tatttgatgc tacaaatgtc ttttcgtggg acacacttga aaatgatatt tttgtcaagc   2220

ttgatgccat tactaagaat tttgagaagc ttgatgaaac tggtaaggca tttatctacc   2280

gcctaattga tttgttgcgt ggggtaaatg agaatcagca aatcaacatt gcacgacttg   2340

cttataccct ttcgagaatg gaagaaaaaa ttggcaaaac atttgctcaa gagctttata   2400

actgggcaaa tgctgataga aaaacattga taatggcact tgaaatttat atattgaaaa   2460

cgagggagag ataatgactg aattaaaaat cggtaatgag aaggtgaact caacgaactt   2520

tggagatttt gccgaaaaag caatcagagg gattaatcac aaaccatttg ttaattcaaa   2580

aggaggtgag caaaaaatta cgacatcaaa aattcgtggt attttagaac tggtaaacaa   2640

agtttataat cgtgtcataa atactaatga tgttgaactt tcagaaaata ttttagctga   2700

tattgcgtat atcaaagtaa aaatcgctta tgaatcaggt cgcgaacctg ttgtgaaaga   2760

ttttattcaa agaacagcat ttaccgctgc aattactgat gtgatgaatc aaagaacccg   2820

cgaaagtttc ttgttattcg cacgttatgt tgaaagtttg attgcctatt ttaaatttta   2880

cggagggaaa gattaatgaa attagtaata gaaggaacga ttgttcttaa aacaggtatg   2940

cacattggtg gttctagtga tttttcggcg attggtgcgg ttgatagccc agtagtccga   3000

gatacgctga cacgtttacc gctcattcca ggaagttcac ttaaaggtaa aatgcgatat   3060

ttgcttgcaa aagagttgaa taatggtatt ttgttgaatg aaccaaataa cgatcaagac   3120

gaaattttgc gactttttgg gtcatcagaa aaagataaga ttcgtcgcgc tcgtctgaaa   3180

ttcaatgata ttaagttatc caatttggct gaacttgaaa ctttcaatgt ctcatcaaca   3240

gaagtgaagt ttgaaaatac gataaataga aaaactgctg ttgctaatcc tcgtcaaatt   3300

gaacgggtga ttgcaggttc aaaattcgat ttcgaaatct tctataatct tgatgatata   3360

aaggaagttg agaaggactt tgaaaatatt aaacaggggt ttgatttact agagtttgac   3420

tacctaggtg gtcatgggac acgtggtagt ggtcgtattg catttgaaaa tttgtcagtc   3480

ataacagccg ttgggaactt tgaaaaaata aatactttaa atgaaatctt aggagcttga   3540

tatgaaaatt atcaaattat attttgaaag tccagttcat tttggtgaaa agcgcctatc   3600

ggagagcaaa ataacttttt cggcagatac cttattttca gctttgatga tcgaggcggt   3660

tggacttgga aaagaagatg aattttatca acttgcttca aataatctcg tcaaattttc   3720

agatgctttc ccttttattg atcaatatta ctatatacca aaaccaatgt tcaatcttaa   3780

attggaaaaa gaagatgaaa atccgtctaa agcttttaaa aaattgctct atgttccgat   3840

agatagttta gaggattatt tatcaggtgg attagatgct tactttgaaa gagaaagctt   3900

taatttagga aaacttgcct tatcggaaaa agttcaacag catgatttta aggactctga   3960

accttacaat gttggcacat ttaccttcaa agaaaataca ggtctttatg tcttgataga   4020

acagactcac ccattattag aggaattatt agaaaacctt caatattcag gaataggtgg   4080

taaacgaaat tcaggctatg gaaaatttaa gtttgaaata ctagaggatt cagacattga   4140

ggacttgttt tcggcaaaag gtaatcgaaa aattttactt tccggtgcct tacccaaaga   4200

tgcagagctt gaacaagccc taaaaaatgc ctcatatctt ttagaacgtc gaggaggttt   4260

tgtccagtct gatacttatg caacaaatct tgtcaaaaaa caagatctat atgttttcaa   4320

aagcggttca acattcgaaa atagctttga cggagacatt tatcaagtag gcaaaaaagg   4380

aaatcatcca gtctataaat atgcgaagtc atttttcttg gaggttagtg tatgaagaag   4440

acatatcgag tgactttaac tgcacttgga ccgattttta ttggcggggg tgagaagctt   4500

aaaaagtatg agtatatttt tgataaacaa aaaaaagttg cacatatgat tgatcatacg   4560

aagtttacta aatacttgtt agaaaaaaat ctattagacg atttcacgag tcgagtcaat   4620

tctcattttg atttatatga ttatttagtc aataaaaaag gaattgtttt catgccatta   4680

gttaagtatt cagtacctgt tgctcaattt agaacagagg taaaaaatag gtttggtaaa   4740

cctatttcta gccctccaat gaatgatttg aatacctttg tcaaagatgc ttttggtaga   4800

ccatatattc caggtagttc tttaaaaggc gctttacgca cagcgatttt gaatgattta   4860

aaggaagata cgaaagaaaa tgaagtcttt gcccatttac aggtatcaga tagtgaaacc   4920

attgaccttg aaaatcttaa ggtttatcaa aaagttgatt attctaaaac ggcaaaaccc   4980

ttgccgcttt atcgagaatg cctgaaaccg aatactgaaa ttacttttac agtatctttt   5040

gatgatgaat atttaacact taaaaaaatt caaaatgctt tgcataaaac ctatcagcat   5100

tattatatta aatggttaaa gggtggaaaa gttggagaaa ctttgataaa gggtgtttat   5160

gatagtcatg ctgacgagtt aaagaaaaat acttttgcat tggatcaacc aagtcaaaat   5220

caaggtgaga tcatttatat cggtggcggt gcagggtttg ttagtaagac cttacattat   5280

aaatcaaaaa atcgcgatca agctcgtaat gattcttttg atattttaaa acagctattt   5340

cgtacaacct acagcaagat gcgttcggta cctgacaatg tcccagttgc tttgaaattg   5400

gctgttgaaa ctaaaacttt taacgggcga gtgacaggga aacactatct tgaaatgggg   5460

aaagcaagaa taaaattgga ggaattgaaa tgaaaatatt gatttcagcc gtaggagata   5520

cagatcctat acgtaatttt cacgatggac cactgctaca tattgtaaga gtttatcgtc   5580

ctgaaaaaat tgttttagtc catagtgaga gaagtttgac taagcatgac aaacttgtca   5640

aggcattgaa aagtatcaaa gactattcac ctgaaatcat tcaagatggg gtcgttttac   5700

cagatgcgca agttgccatc tttgatgaga tgtatgatac tgtatcaagt attgttaaaa   5760

aatatatatc tgatgatgaa attatcttaa atatctccag tgcgacaccg caaatcatca   5820

gtgctatgtt tgcggtgaat cgtatctctg attttaatgt cacagctgtt caagttaaga   5880

caccgcagca taagtcaaac gaagggctgc ggcatgataa tcaagaagat attgataaat   5940

tgattgagac gaatcttgat aatcagtctg attatgagaa tagaacactt gcagatactg   6000

gtatgaaatt ttcacaagat ttgacgaaac gaaatttaaa agctttgatt gataattatg   6060

attatcaggg agctttagaa cttcttaaaa aacagaaatc attttcaaat attaaggagt   6120

taagaaaaaa attaacagag atttcagata caatcaaaat tcaaggaatg ccagataaaa   6180

tcgttaaatc taaattatcc aatcaagcaa agagtgcttt aaattcctat ttaaatattg   6240

accgaaatca caagcaaggt aatattgcag aggtgttgat tcgagtaaaa tctcttgtag   6300

aatttatttt agaagattat ctaaataatc attttttaga tgtcatcact tacaaagatg   6360

gcaaaccatt tttaaatgct tcaaaatatc ctgagattct gaaaaagttt caggaagatg   6420

ccgaaatgag gggtaaggaa taccatagcg gttatttgag cctccctgct tacattggta   6480

ttctcaaatt tttcgaacca aatcatgact tattaaaaca tatttataag attcaagaaa   6540

ttaaccaaga cagaaataaa gtagcgcaca gtctacaagc ttttgatagg aaaaatttga   6600

agaaagtatc tagcgcagtt tttgcaagta aacaaattct gttagcttct tttgacattg   6660

ataatcattg gttctctttc tatgaggatt taaatcagga aataaaaaaa ttactatgat   6720

cgttaaactc cgatacaaaa taaacctgcc aaattcgctt cgtacccaaa acatcgggag   6780

cactctccat ggtgttttga tggaattatt acccagtgaa ctggtagagc accttcataa   6840

cttaagctac aatccatttc gtcagagatt aatttttgaa aaagagctag tcatttggga   6900

aattgtgggc ttgcacaaaa tggtctcgga agagctgtta aaactcgaaa atttaaggga   6960

aataacaatc aaacgtgccc aaaagactgt ttccttatcc ttactctcca aagatgcaat   7020

cgcagttgat gatttggtga aaaaagaaat gggacgcgaa attgacagtc gaattatctc   7080

gcttaaattt acaagtccaa cctcatttaa agccaatggg cattatgaca tttttccaga   7140

tattcgaaaa attttccgtt ctttaatgat gaattttgat ttttttagtg aaacaactaa   7200

aatttatgat tacgaggttt tgtcgtacat tgaagaaaat gtccatattg tcagctataa   7260

attgatgaca aagaattttc atctcgagaa gataaaagta aaaggttttc aaggtgacat   7320

gacgctcaaa gtaactggcg cagaacagtt cgtaaaatta gtcttactta tgatcaaata   7380

tgcgactttc gcaggcattg gtatgaaaac aagccttggt atgggaggag tttccatcaa   7440

tgagagacat tatctacgtt gaaaataggt attttatcag tagtcgagaa aatgcgctca   7500

gatttcatga ctatattaat aaagcgaccc atttcattgc ttttgatgac attgatattt   7560

tagttttgga taatgcaaga agttacttgt caaatggtgt gattaacgac tgtttggatc   7620

gaaatatttt gattttaact tgcgataata aacattctcc taaagcgatt ttaagcaatg   7680

cttttgctaa taaaaaacgc ttagaacgct taagaaatca attgcaatta tcctctaagt   7740

caaagaatcg tctttggcgt aaaattgtga tggcgaaaat taataatcag gctgatgctg   7800

ttaccttcac ggttcaagat ggaacagttc atcgagagat aattgaacta ggaaaaatgg   7860

tcacagaagg agataaagat aatcgcgaag ctgtcgttgc acgaaaatat tttcggacat   7920

tatttggtgg taattttaag cgtggtcgtt ttgatgatgt catcaattca gcgctcaatt   7980

atggctatgc acttgtgagg gctgtcatca gacgagaatt ggctatctgt ggttttgaga   8040

tgagctttgg tattcatcat atgtcaacag aaaatccttt taatctctct gatgatatga   8100

ttgaagtttt tcggcctttt gttgatgtgt tggtatttga gataattgtg acgaactaca   8160

agcggaagtt caaaagggct atcaaagttt tttaactgaa aaacactatt cactttctga   8220

catgcgtaag gattttggca tcaatggcgc atgaatttaa acttgtattc tcagaagaat   8280

ctaaacgtta tttaaagaag atttacgact acattgtttt aaatttcttc tctgaaattt   8340

ctgctcgtag aaaagttgac ttacttttgt taggaagtga agtgttggag aaaattccag   8400

aattaggttt tgatgttttt caaaagacag gtaaaaaatt tctgggaatg gaaaatattc   8460

ggattctagt gattgaaaaa tatttggcag tttatcagat tgattttgaa gaaaacacaa   8520

tcaatatttt tcgtttttta aatattaaaa ccaattattt acggtacttg agatagcttt   8580

ttactttgat ttttgctata cttaagaaat aacaattaaa ctttttcaat ctacctgtag   8640

gtcaatctag cccattgttt tggtcgatat ttgaccaaga caatagcgcg gaaaagctta   8700

ctacaaacac gtttttaaag ttctctaaat acaaccgctc ctcgataaaa ggggacgaga   8760

actgcatgtt tatagccctg ccggatttta agctgcgaaa tacaaccgct cctcgataaa   8820

aggggacgag aactttccat tccgtttaac tgctgccaga aagatttcat caaatacaac   8880

cgctcctcga taaaagggga cgagaactgg ttgttgtcat tagctgtatc gtgaatgacg   8940

atataaaata caaccgctcc tcgataaaag gggacgagaa caacttggaa tggtaattca   9000

tataattttt tcataaaata caaccgctcc tcgataaaag gggacgagaa ctgctggttt   9060

tatttgctca atttttgaat tgtcaaaaat acaaccgctc ctcgataaaa ggggacgaga   9120

actttgttgt aaaatatttc atgttttgtt ttctcttttc taaatacaac cgctcctcga   9180

taaaagggga cgagaacaga gagtattcag tcatgaatga aatgattgca atttgaaata   9240

caaccgctcc tcgataaaag gggacgagaa cacaactgtt ttaactctat cctgatatat   9300

aaacccaaat acaaccgctc ctcgataaaa ggggacgaga acaacttttt aaggataaga   9360

ccaacagact ctgacaaata caaccgctcc tcgataaaag gggacgagaa ctttatttgt   9420

ggcaacaagt tcagcaataa tagggtttaa atacaaccgc tcctcgataa aaggggacga   9480

gaacgaactt agcaagctat tttgtttctt ttcaagagcc aaaatacaac cgctcctcga   9540

taaaagggga cgagaacata cgttctttga accaagcttc aactccctcg gaaaatacaa   9600

ccgctcctcg ataaaagggg acgagaactt ctgttaattt aactcccatt tgttagttct   9660

cctaaataca accgctcctc gataaaaggg gacgagaact ttttaaaatg ttgcaaatgt   9720

ttagctactt catgaaatac aaccgctcct cgataaaagg ggacgagaac atatgtcggt   9780

ttgtcttttg gtctaacgta tgcaaaatac aaccgctcct cgataaaagg ggacgagaac   9840

catatgattc aggtattgct tctacaccaa gtt                                9873


<210>  2
<211>  200
<212>  DNA
<213>  Lactococcus lactis

<400>  2
tcgtgcgctt tctaattctt agtggtttaa gactaggata gcacgactta tatatttttc     60

aatgaaatca actagcaatt cgggtttata atgtgtttat ttatggaaaa aattatcatt    120

aaaaatcaag aaaatagttg gcaaacaaga ttgtttaacg taaaataata tcctttacca    180

aaaaaggtag aaagaatttt                                                200


<210>  3
<211>  2274
<212>  DNA
<213>  Lactococcus lactis

<400>  3
atggacaaaa taaatttagt atgtggttca cttttacacg atattggaaa aattatttat     60

cgtggtacta gcgaacgagc aaagcactct aaacttggtg gagatttcat caaatccttt    120

gagcaattta gaaatacaga attgactgat tgtatccgat atcatcatgc ccaagaaatc    180

acatctgtga aatcaaataa ggaaaaaaac tcactgtttt atataactta tatcgctgat    240

aacatttcat cgggtatgga tagacgaaaa gatttggaag aaggtgcaga aggatttaat    300

tgggataaaa aagttgcgct tggtagtgtt tttaatgtac tgaacgaaaa agaaaaggga    360

cggcaaaact attcatatcc gtttgtggca agaacacgga taaaagaaga gccactaaat    420

tttccaactg ctactcaaaa tcagtataca acttcctatt atgacggttt aattactgat    480

atgaaaacga ttttacagcg acttaagcca gataaggaac acatcaactc tttgctgcaa    540

atgatggaaa gtctgtggtc ttacgtccca agttcgactg ataaaaatca gttggttgat    600

atttctcttt acgaccattc gagaacgact gcggcgattg caagtgctat ttatgactat    660

tttcaggcag aaaatatcac tgattatcaa aaagaattat ttgattataa tgctacggaa    720

ttttatgata aaaatgcctt tttgatgatg aattttgata tgagcggtgt tcagaatttt    780

atttataata tttctggtag taaagctttg aaatcgttac gagcgcgaag tttttatctg    840

gatatgttgt tggaatatat ttctgataat ttactcgaaa aactggaatt atctcgtgct    900

aatattctat atgttggtgg cggtcatgcc tatcttttat tagccaatac gaacaaaact    960

aaggctattt tatctgattt tgagcatgac ttaaaaacat ggtttttgga taaattcaag   1020

atagatttgt atgttgcaat ggcttataca gaagtttctg ctaatgactt gatgaatcat   1080

aatggtcatt accgtgatat ttatcgtcgt ttatcccaaa aaacatcagc taagaaagct   1140

aaccgctata ctgctgaaga aattttaaat ttaaaccatc aaggtacgga aaatgctcgt   1200

gagtgtcgcg aatgtaaacg aagtgattta ttgatagaag aagatgatat ttgtgaaatt   1260

tgtgatagtc tacaaaaagt ttcgagagat ttgacaagag aaaatatttt tgtgattgca   1320

aatgaaggag tgcttgacat gccttttggt aaaaagatgt ctgcactatc ttatagtcaa   1380

gctgataagc taaagaaaag caatgccgaa gttcaaattt atgccaagaa catctctgaa   1440

attggacaaa atttgatgac acgaattgat atgggagatt atacttatcg ttcagacttt   1500

catgaaatgt tagaagaagt tgaagtaggc atcaatcgtc taggcgtact tcgagcagat   1560

gttgataatc ttggtcaagc ctttattaac ggtattccag atgactattt gtcaatctct   1620

agaaccgcaa cattctcacg tgccatgagt agatttttca aaaattatct caatcaactt   1680

ttggctgaga aaagctataa aatcaacgtt atttatgctg gcggtgatga cttattcatg   1740

attggcgctt ggcaagatat tttagatttt tcgattgtgc ttaagcaaaa gtttgctgac   1800

tttacacaaa ataaattgtc gatttctgca ggtattggca tgttcagaga aaaatatcct   1860

gtggctagaa tggcaagtct gacaggagat ttagaggacg cagcaaagga ctataagcct   1920

gatgaaagag ctgtccaagc aacaaaaaat gcggtgacat tatttgatgc tacaaatgtc   1980

ttttcgtggg acacacttga aaatgatatt tttgtcaagc ttgatgccat tactaagaat   2040

tttgagaagc ttgatgaaac tggtaaggca tttatctacc gcctaattga tttgttgcgt   2100

ggggtaaatg agaatcagca aatcaacatt gcacgacttg cttataccct ttcgagaatg   2160

gaagaaaaaa ttggcaaaac atttgctcaa gagctttata actgggcaaa tgctgataga   2220

aaaacattga taatggcact tgaaatttat atattgaaaa cgagggagag ataa         2274


<210>  4
<211>  757
<212>  PRT
<213>  Lactococcus lactis

<400>  4

Met Asp Lys Ile Asn Leu Val Cys Gly Ser Leu Leu His Asp Ile Gly 
1               5                   10                  15      


Lys Ile Ile Tyr Arg Gly Thr Ser Glu Arg Ala Lys His Ser Lys Leu 
            20                  25                  30          


Gly Gly Asp Phe Ile Lys Ser Phe Glu Gln Phe Arg Asn Thr Glu Leu 
        35                  40                  45              


Thr Asp Cys Ile Arg Tyr His His Ala Gln Glu Ile Thr Ser Val Lys 
    50                  55                  60                  


Ser Asn Lys Glu Lys Asn Ser Leu Phe Tyr Ile Thr Tyr Ile Ala Asp 
65                  70                  75                  80  


Asn Ile Ser Ser Gly Met Asp Arg Arg Lys Asp Leu Glu Glu Gly Ala 
                85                  90                  95      


Glu Gly Phe Asn Trp Asp Lys Lys Val Ala Leu Gly Ser Val Phe Asn 
            100                 105                 110         


Val Leu Asn Glu Lys Glu Lys Gly Arg Gln Asn Tyr Ser Tyr Pro Phe 
        115                 120                 125             


Val Ala Arg Thr Arg Ile Lys Glu Glu Pro Leu Asn Phe Pro Thr Ala 
    130                 135                 140                 


Thr Gln Asn Gln Tyr Thr Thr Ser Tyr Tyr Asp Gly Leu Ile Thr Asp 
145                 150                 155                 160 


Met Lys Thr Ile Leu Gln Arg Leu Lys Pro Asp Lys Glu His Ile Asn 
                165                 170                 175     


Ser Leu Leu Gln Met Met Glu Ser Leu Trp Ser Tyr Val Pro Ser Ser 
            180                 185                 190         


Thr Asp Lys Asn Gln Leu Val Asp Ile Ser Leu Tyr Asp His Ser Arg 
        195                 200                 205             


Thr Thr Ala Ala Ile Ala Ser Ala Ile Tyr Asp Tyr Phe Gln Ala Glu 
    210                 215                 220                 


Asn Ile Thr Asp Tyr Gln Lys Glu Leu Phe Asp Tyr Asn Ala Thr Glu 
225                 230                 235                 240 


Phe Tyr Asp Lys Asn Ala Phe Leu Met Met Asn Phe Asp Met Ser Gly 
                245                 250                 255     


Val Gln Asn Phe Ile Tyr Asn Ile Ser Gly Ser Lys Ala Leu Lys Ser 
            260                 265                 270         


Leu Arg Ala Arg Ser Phe Tyr Leu Asp Met Leu Leu Glu Tyr Ile Ser 
        275                 280                 285             


Asp Asn Leu Leu Glu Lys Leu Glu Leu Ser Arg Ala Asn Ile Leu Tyr 
    290                 295                 300                 


Val Gly Gly Gly His Ala Tyr Leu Leu Leu Ala Asn Thr Asn Lys Thr 
305                 310                 315                 320 


Lys Ala Ile Leu Ser Asp Phe Glu His Asp Leu Lys Thr Trp Phe Leu 
                325                 330                 335     


Asp Lys Phe Lys Ile Asp Leu Tyr Val Ala Met Ala Tyr Thr Glu Val 
            340                 345                 350         


Ser Ala Asn Asp Leu Met Asn His Asn Gly His Tyr Arg Asp Ile Tyr 
        355                 360                 365             


Arg Arg Leu Ser Gln Lys Thr Ser Ala Lys Lys Ala Asn Arg Tyr Thr 
    370                 375                 380                 


Ala Glu Glu Ile Leu Asn Leu Asn His Gln Gly Thr Glu Asn Ala Arg 
385                 390                 395                 400 


Glu Cys Arg Glu Cys Lys Arg Ser Asp Leu Leu Ile Glu Glu Asp Asp 
                405                 410                 415     


Ile Cys Glu Ile Cys Asp Ser Leu Gln Lys Val Ser Arg Asp Leu Thr 
            420                 425                 430         


Arg Glu Asn Ile Phe Val Ile Ala Asn Glu Gly Val Leu Asp Met Pro 
        435                 440                 445             


Phe Gly Lys Lys Met Ser Ala Leu Ser Tyr Ser Gln Ala Asp Lys Leu 
    450                 455                 460                 


Lys Lys Ser Asn Ala Glu Val Gln Ile Tyr Ala Lys Asn Ile Ser Glu 
465                 470                 475                 480 


Ile Gly Gln Asn Leu Met Thr Arg Ile Asp Met Gly Asp Tyr Thr Tyr 
                485                 490                 495     


Arg Ser Asp Phe His Glu Met Leu Glu Glu Val Glu Val Gly Ile Asn 
            500                 505                 510         


Arg Leu Gly Val Leu Arg Ala Asp Val Asp Asn Leu Gly Gln Ala Phe 
        515                 520                 525             


Ile Asn Gly Ile Pro Asp Asp Tyr Leu Ser Ile Ser Arg Thr Ala Thr 
    530                 535                 540                 


Phe Ser Arg Ala Met Ser Arg Phe Phe Lys Asn Tyr Leu Asn Gln Leu 
545                 550                 555                 560 


Leu Ala Glu Lys Ser Tyr Lys Ile Asn Val Ile Tyr Ala Gly Gly Asp 
                565                 570                 575     


Asp Leu Phe Met Ile Gly Ala Trp Gln Asp Ile Leu Asp Phe Ser Ile 
            580                 585                 590         


Val Leu Lys Gln Lys Phe Ala Asp Phe Thr Gln Asn Lys Leu Ser Ile 
        595                 600                 605             


Ser Ala Gly Ile Gly Met Phe Arg Glu Lys Tyr Pro Val Ala Arg Met 
    610                 615                 620                 


Ala Ser Leu Thr Gly Asp Leu Glu Asp Ala Ala Lys Asp Tyr Lys Pro 
625                 630                 635                 640 


Asp Glu Arg Ala Val Gln Ala Thr Lys Asn Ala Val Thr Leu Phe Asp 
                645                 650                 655     


Ala Thr Asn Val Phe Ser Trp Asp Thr Leu Glu Asn Asp Ile Phe Val 
            660                 665                 670         


Lys Leu Asp Ala Ile Thr Lys Asn Phe Glu Lys Leu Asp Glu Thr Gly 
        675                 680                 685             


Lys Ala Phe Ile Tyr Arg Leu Ile Asp Leu Leu Arg Gly Val Asn Glu 
    690                 695                 700                 


Asn Gln Gln Ile Asn Ile Ala Arg Leu Ala Tyr Thr Leu Ser Arg Met 
705                 710                 715                 720 


Glu Glu Lys Ile Gly Lys Thr Phe Ala Gln Glu Leu Tyr Asn Trp Ala 
                725                 730                 735     


Asn Ala Asp Arg Lys Thr Leu Ile Met Ala Leu Glu Ile Tyr Ile Leu 
            740                 745                 750         


Lys Thr Arg Glu Arg 
        755         


<210>  5
<211>  423
<212>  DNA
<213>  Lactococcus lactis

<400>  5
atgactgaat taaaaatcgg taatgagaag gtgaactcaa cgaactttgg agattttgcc     60

gaaaaagcaa tcagagggat taatcacaaa ccatttgtta attcaaaagg aggtgagcaa    120

aaaattacga catcaaaaat tcgtggtatt ttagaactgg taaacaaagt ttataatcgt    180

gtcataaata ctaatgatgt tgaactttca gaaaatattt tagctgatat tgcgtatatc    240

aaagtaaaaa tcgcttatga atcaggtcgc gaacctgttg tgaaagattt tattcaaaga    300

acagcattta ccgctgcaat tactgatgtg atgaatcaaa gaacccgcga aagtttcttg    360

ttattcgcac gttatgttga aagtttgatt gcctatttta aattttacgg agggaaagat    420

taa                                                                  423


<210>  6
<211>  140
<212>  PRT
<213>  Lactococcus lactis

<400>  6

Met Thr Glu Leu Lys Ile Gly Asn Glu Lys Val Asn Ser Thr Asn Phe 
1               5                   10                  15      


Gly Asp Phe Ala Glu Lys Ala Ile Arg Gly Ile Asn His Lys Pro Phe 
            20                  25                  30          


Val Asn Ser Lys Gly Gly Glu Gln Lys Ile Thr Thr Ser Lys Ile Arg 
        35                  40                  45              


Gly Ile Leu Glu Leu Val Asn Lys Val Tyr Asn Arg Val Ile Asn Thr 
    50                  55                  60                  


Asn Asp Val Glu Leu Ser Glu Asn Ile Leu Ala Asp Ile Ala Tyr Ile 
65                  70                  75                  80  


Lys Val Lys Ile Ala Tyr Glu Ser Gly Arg Glu Pro Val Val Lys Asp 
                85                  90                  95      


Phe Ile Gln Arg Thr Ala Phe Thr Ala Ala Ile Thr Asp Val Met Asn 
            100                 105                 110         


Gln Arg Thr Arg Glu Ser Phe Leu Leu Phe Ala Arg Tyr Val Glu Ser 
        115                 120                 125             


Leu Ile Ala Tyr Phe Lys Phe Tyr Gly Gly Lys Asp 
    130                 135                 140 


<210>  7
<211>  645
<212>  DNA
<213>  Lactococcus lactis

<400>  7
atgaaattag taatagaagg aacgattgtt cttaaaacag gtatgcacat tggtggttct     60

agtgattttt cggcgattgg tgcggttgat agcccagtag tccgagatac gctgacacgt    120

ttaccgctca ttccaggaag ttcacttaaa ggtaaaatgc gatatttgct tgcaaaagag    180

ttgaataatg gtattttgtt gaatgaacca aataacgatc aagacgaaat tttgcgactt    240

tttgggtcat cagaaaaaga taagattcgt cgcgctcgtc tgaaattcaa tgatattaag    300

ttatccaatt tggctgaact tgaaactttc aatgtctcat caacagaagt gaagtttgaa    360

aatacgataa atagaaaaac tgctgttgct aatcctcgtc aaattgaacg ggtgattgca    420

ggttcaaaat tcgatttcga aatcttctat aatcttgatg atataaagga agttgagaag    480

gactttgaaa atattaaaca ggggtttgat ttactagagt ttgactacct aggtggtcat    540

gggacacgtg gtagtggtcg tattgcattt gaaaatttgt cagtcataac agccgttggg    600

aactttgaaa aaataaatac tttaaatgaa atcttaggag cttga                    645


<210>  8
<211>  214
<212>  PRT
<213>  Lactococcus lactis

<400>  8

Met Lys Leu Val Ile Glu Gly Thr Ile Val Leu Lys Thr Gly Met His 
1               5                   10                  15      


Ile Gly Gly Ser Ser Asp Phe Ser Ala Ile Gly Ala Val Asp Ser Pro 
            20                  25                  30          


Val Val Arg Asp Thr Leu Thr Arg Leu Pro Leu Ile Pro Gly Ser Ser 
        35                  40                  45              


Leu Lys Gly Lys Met Arg Tyr Leu Leu Ala Lys Glu Leu Asn Asn Gly 
    50                  55                  60                  


Ile Leu Leu Asn Glu Pro Asn Asn Asp Gln Asp Glu Ile Leu Arg Leu 
65                  70                  75                  80  


Phe Gly Ser Ser Glu Lys Asp Lys Ile Arg Arg Ala Arg Leu Lys Phe 
                85                  90                  95      


Asn Asp Ile Lys Leu Ser Asn Leu Ala Glu Leu Glu Thr Phe Asn Val 
            100                 105                 110         


Ser Ser Thr Glu Val Lys Phe Glu Asn Thr Ile Asn Arg Lys Thr Ala 
        115                 120                 125             


Val Ala Asn Pro Arg Gln Ile Glu Arg Val Ile Ala Gly Ser Lys Phe 
    130                 135                 140                 


Asp Phe Glu Ile Phe Tyr Asn Leu Asp Asp Ile Lys Glu Val Glu Lys 
145                 150                 155                 160 


Asp Phe Glu Asn Ile Lys Gln Gly Phe Asp Leu Leu Glu Phe Asp Tyr 
                165                 170                 175     


Leu Gly Gly His Gly Thr Arg Gly Ser Gly Arg Ile Ala Phe Glu Asn 
            180                 185                 190         


Leu Ser Val Ile Thr Ala Val Gly Asn Phe Glu Lys Ile Asn Thr Leu 
        195                 200                 205             


Asn Glu Ile Leu Gly Ala 
    210                 


<210>  9
<211>  894
<212>  DNA
<213>  Lactococcus lactis

<400>  9
atgaaaatta tcaaattata ttttgaaagt ccagttcatt ttggtgaaaa gcgcctatcg     60

gagagcaaaa taactttttc ggcagatacc ttattttcag ctttgatgat cgaggcggtt    120

ggacttggaa aagaagatga attttatcaa cttgcttcaa ataatctcgt caaattttca    180

gatgctttcc cttttattga tcaatattac tatataccaa aaccaatgtt caatcttaaa    240

ttggaaaaag aagatgaaaa tccgtctaaa gcttttaaaa aattgctcta tgttccgata    300

gatagtttag aggattattt atcaggtgga ttagatgctt actttgaaag agaaagcttt    360

aatttaggaa aacttgcctt atcggaaaaa gttcaacagc atgattttaa ggactctgaa    420

ccttacaatg ttggcacatt taccttcaaa gaaaatacag gtctttatgt cttgatagaa    480

cagactcacc cattattaga ggaattatta gaaaaccttc aatattcagg aataggtggt    540

aaacgaaatt caggctatgg aaaatttaag tttgaaatac tagaggattc agacattgag    600

gacttgtttt cggcaaaagg taatcgaaaa attttacttt ccggtgcctt acccaaagat    660

gcagagcttg aacaagccct aaaaaatgcc tcatatcttt tagaacgtcg aggaggtttt    720

gtccagtctg atacttatgc aacaaatctt gtcaaaaaac aagatctata tgttttcaaa    780

agcggttcaa cattcgaaaa tagctttgac ggagacattt atcaagtagg caaaaaagga    840

aatcatccag tctataaata tgcgaagtca tttttcttgg aggttagtgt atga          894


<210>  10
<211>  297
<212>  PRT
<213>  Lactococcus lactis

<400>  10

Met Lys Ile Ile Lys Leu Tyr Phe Glu Ser Pro Val His Phe Gly Glu 
1               5                   10                  15      


Lys Arg Leu Ser Glu Ser Lys Ile Thr Phe Ser Ala Asp Thr Leu Phe 
            20                  25                  30          


Ser Ala Leu Met Ile Glu Ala Val Gly Leu Gly Lys Glu Asp Glu Phe 
        35                  40                  45              


Tyr Gln Leu Ala Ser Asn Asn Leu Val Lys Phe Ser Asp Ala Phe Pro 
    50                  55                  60                  


Phe Ile Asp Gln Tyr Tyr Tyr Ile Pro Lys Pro Met Phe Asn Leu Lys 
65                  70                  75                  80  


Leu Glu Lys Glu Asp Glu Asn Pro Ser Lys Ala Phe Lys Lys Leu Leu 
                85                  90                  95      


Tyr Val Pro Ile Asp Ser Leu Glu Asp Tyr Leu Ser Gly Gly Leu Asp 
            100                 105                 110         


Ala Tyr Phe Glu Arg Glu Ser Phe Asn Leu Gly Lys Leu Ala Leu Ser 
        115                 120                 125             


Glu Lys Val Gln Gln His Asp Phe Lys Asp Ser Glu Pro Tyr Asn Val 
    130                 135                 140                 


Gly Thr Phe Thr Phe Lys Glu Asn Thr Gly Leu Tyr Val Leu Ile Glu 
145                 150                 155                 160 


Gln Thr His Pro Leu Leu Glu Glu Leu Leu Glu Asn Leu Gln Tyr Ser 
                165                 170                 175     


Gly Ile Gly Gly Lys Arg Asn Ser Gly Tyr Gly Lys Phe Lys Phe Glu 
            180                 185                 190         


Ile Leu Glu Asp Ser Asp Ile Glu Asp Leu Phe Ser Ala Lys Gly Asn 
        195                 200                 205             


Arg Lys Ile Leu Leu Ser Gly Ala Leu Pro Lys Asp Ala Glu Leu Glu 
    210                 215                 220                 


Gln Ala Leu Lys Asn Ala Ser Tyr Leu Leu Glu Arg Arg Gly Gly Phe 
225                 230                 235                 240 


Val Gln Ser Asp Thr Tyr Ala Thr Asn Leu Val Lys Lys Gln Asp Leu 
                245                 250                 255     


Tyr Val Phe Lys Ser Gly Ser Thr Phe Glu Asn Ser Phe Asp Gly Asp 
            260                 265                 270         


Ile Tyr Gln Val Gly Lys Lys Gly Asn His Pro Val Tyr Lys Tyr Ala 
        275                 280                 285             


Lys Ser Phe Phe Leu Glu Val Ser Val 
    290                 295         


<210>  11
<211>  1062
<212>  DNA
<213>  Lactococcus lactis

<400>  11
atgaagaaga catatcgagt gactttaact gcacttggac cgatttttat tggcgggggt     60

gagaagctta aaaagtatga gtatattttt gataaacaaa aaaaagttgc acatatgatt    120

gatcatacga agtttactaa atacttgtta gaaaaaaatc tattagacga tttcacgagt    180

cgagtcaatt ctcattttga tttatatgat tatttagtca ataaaaaagg aattgttttc    240

atgccattag ttaagtattc agtacctgtt gctcaattta gaacagaggt aaaaaatagg    300

tttggtaaac ctatttctag ccctccaatg aatgatttga atacctttgt caaagatgct    360

tttggtagac catatattcc aggtagttct ttaaaaggcg ctttacgcac agcgattttg    420

aatgatttaa aggaagatac gaaagaaaat gaagtctttg cccatttaca ggtatcagat    480

agtgaaacca ttgaccttga aaatcttaag gtttatcaaa aagttgatta ttctaaaacg    540

gcaaaaccct tgccgcttta tcgagaatgc ctgaaaccga atactgaaat tacttttaca    600

gtatcttttg atgatgaata tttaacactt aaaaaaattc aaaatgcttt gcataaaacc    660

tatcagcatt attatattaa atggttaaag ggtggaaaag ttggagaaac tttgataaag    720

ggtgtttatg atagtcatgc tgacgagtta aagaaaaata cttttgcatt ggatcaacca    780

agtcaaaatc aaggtgagat catttatatc ggtggcggtg cagggtttgt tagtaagacc    840

ttacattata aatcaaaaaa tcgcgatcaa gctcgtaatg attcttttga tattttaaaa    900

cagctatttc gtacaaccta cagcaagatg cgttcggtac ctgacaatgt cccagttgct    960

ttgaaattgg ctgttgaaac taaaactttt aacgggcgag tgacagggaa acactatctt   1020

gaaatgggga aagcaagaat aaaattggag gaattgaaat ga                      1062


<210>  12
<211>  353
<212>  PRT
<213>  Lactococcus lactis

<400>  12

Met Lys Lys Thr Tyr Arg Val Thr Leu Thr Ala Leu Gly Pro Ile Phe 
1               5                   10                  15      


Ile Gly Gly Gly Glu Lys Leu Lys Lys Tyr Glu Tyr Ile Phe Asp Lys 
            20                  25                  30          


Gln Lys Lys Val Ala His Met Ile Asp His Thr Lys Phe Thr Lys Tyr 
        35                  40                  45              


Leu Leu Glu Lys Asn Leu Leu Asp Asp Phe Thr Ser Arg Val Asn Ser 
    50                  55                  60                  


His Phe Asp Leu Tyr Asp Tyr Leu Val Asn Lys Lys Gly Ile Val Phe 
65                  70                  75                  80  


Met Pro Leu Val Lys Tyr Ser Val Pro Val Ala Gln Phe Arg Thr Glu 
                85                  90                  95      


Val Lys Asn Arg Phe Gly Lys Pro Ile Ser Ser Pro Pro Met Asn Asp 
            100                 105                 110         


Leu Asn Thr Phe Val Lys Asp Ala Phe Gly Arg Pro Tyr Ile Pro Gly 
        115                 120                 125             


Ser Ser Leu Lys Gly Ala Leu Arg Thr Ala Ile Leu Asn Asp Leu Lys 
    130                 135                 140                 


Glu Asp Thr Lys Glu Asn Glu Val Phe Ala His Leu Gln Val Ser Asp 
145                 150                 155                 160 


Ser Glu Thr Ile Asp Leu Glu Asn Leu Lys Val Tyr Gln Lys Val Asp 
                165                 170                 175     


Tyr Ser Lys Thr Ala Lys Pro Leu Pro Leu Tyr Arg Glu Cys Leu Lys 
            180                 185                 190         


Pro Asn Thr Glu Ile Thr Phe Thr Val Ser Phe Asp Asp Glu Tyr Leu 
        195                 200                 205             


Thr Leu Lys Lys Ile Gln Asn Ala Leu His Lys Thr Tyr Gln His Tyr 
    210                 215                 220                 


Tyr Ile Lys Trp Leu Lys Gly Gly Lys Val Gly Glu Thr Leu Ile Lys 
225                 230                 235                 240 


Gly Val Tyr Asp Ser His Ala Asp Glu Leu Lys Lys Asn Thr Phe Ala 
                245                 250                 255     


Leu Asp Gln Pro Ser Gln Asn Gln Gly Glu Ile Ile Tyr Ile Gly Gly 
            260                 265                 270         


Gly Ala Gly Phe Val Ser Lys Thr Leu His Tyr Lys Ser Lys Asn Arg 
        275                 280                 285             


Asp Gln Ala Arg Asn Asp Ser Phe Asp Ile Leu Lys Gln Leu Phe Arg 
    290                 295                 300                 


Thr Thr Tyr Ser Lys Met Arg Ser Val Pro Asp Asn Val Pro Val Ala 
305                 310                 315                 320 


Leu Lys Leu Ala Val Glu Thr Lys Thr Phe Asn Gly Arg Val Thr Gly 
                325                 330                 335     


Lys His Tyr Leu Glu Met Gly Lys Ala Arg Ile Lys Leu Glu Glu Leu 
            340                 345                 350         


Lys 
    


<210>  13
<211>  1230
<212>  DNA
<213>  Lactococcus lactis

<400>  13
atgaaaatat tgatttcagc cgtaggagat acagatccta tacgtaattt tcacgatgga     60

ccactgctac atattgtaag agtttatcgt cctgaaaaaa ttgttttagt ccatagtgag    120

agaagtttga ctaagcatga caaacttgtc aaggcattga aaagtatcaa agactattca    180

cctgaaatca ttcaagatgg ggtcgtttta ccagatgcgc aagttgccat ctttgatgag    240

atgtatgata ctgtatcaag tattgttaaa aaatatatat ctgatgatga aattatctta    300

aatatctcca gtgcgacacc gcaaatcatc agtgctatgt ttgcggtgaa tcgtatctct    360

gattttaatg tcacagctgt tcaagttaag acaccgcagc ataagtcaaa cgaagggctg    420

cggcatgata atcaagaaga tattgataaa ttgattgaga cgaatcttga taatcagtct    480

gattatgaga atagaacact tgcagatact ggtatgaaat tttcacaaga tttgacgaaa    540

cgaaatttaa aagctttgat tgataattat gattatcagg gagctttaga acttcttaaa    600

aaacagaaat cattttcaaa tattaaggag ttaagaaaaa aattaacaga gatttcagat    660

acaatcaaaa ttcaaggaat gccagataaa atcgttaaat ctaaattatc caatcaagca    720

aagagtgctt taaattccta tttaaatatt gaccgaaatc acaagcaagg taatattgca    780

gaggtgttga ttcgagtaaa atctcttgta gaatttattt tagaagatta tctaaataat    840

cattttttag atgtcatcac ttacaaagat ggcaaaccat ttttaaatgc ttcaaaatat    900

cctgagattc tgaaaaagtt tcaggaagat gccgaaatga ggggtaagga ataccatagc    960

ggttatttga gcctccctgc ttacattggt attctcaaat ttttcgaacc aaatcatgac   1020

ttattaaaac atatttataa gattcaagaa attaaccaag acagaaataa agtagcgcac   1080

agtctacaag cttttgatag gaaaaatttg aagaaagtat ctagcgcagt ttttgcaagt   1140

aaacaaattc tgttagcttc ttttgacatt gataatcatt ggttctcttt ctatgaggat   1200

ttaaatcagg aaataaaaaa attactatga                                    1230


<210>  14
<211>  409
<212>  PRT
<213>  Lactococcus lactis

<400>  14

Met Lys Ile Leu Ile Ser Ala Val Gly Asp Thr Asp Pro Ile Arg Asn 
1               5                   10                  15      


Phe His Asp Gly Pro Leu Leu His Ile Val Arg Val Tyr Arg Pro Glu 
            20                  25                  30          


Lys Ile Val Leu Val His Ser Glu Arg Ser Leu Thr Lys His Asp Lys 
        35                  40                  45              


Leu Val Lys Ala Leu Lys Ser Ile Lys Asp Tyr Ser Pro Glu Ile Ile 
    50                  55                  60                  


Gln Asp Gly Val Val Leu Pro Asp Ala Gln Val Ala Ile Phe Asp Glu 
65                  70                  75                  80  


Met Tyr Asp Thr Val Ser Ser Ile Val Lys Lys Tyr Ile Ser Asp Asp 
                85                  90                  95      


Glu Ile Ile Leu Asn Ile Ser Ser Ala Thr Pro Gln Ile Ile Ser Ala 
            100                 105                 110         


Met Phe Ala Val Asn Arg Ile Ser Asp Phe Asn Val Thr Ala Val Gln 
        115                 120                 125             


Val Lys Thr Pro Gln His Lys Ser Asn Glu Gly Leu Arg His Asp Asn 
    130                 135                 140                 


Gln Glu Asp Ile Asp Lys Leu Ile Glu Thr Asn Leu Asp Asn Gln Ser 
145                 150                 155                 160 


Asp Tyr Glu Asn Arg Thr Leu Ala Asp Thr Gly Met Lys Phe Ser Gln 
                165                 170                 175     


Asp Leu Thr Lys Arg Asn Leu Lys Ala Leu Ile Asp Asn Tyr Asp Tyr 
            180                 185                 190         


Gln Gly Ala Leu Glu Leu Leu Lys Lys Gln Lys Ser Phe Ser Asn Ile 
        195                 200                 205             


Lys Glu Leu Arg Lys Lys Leu Thr Glu Ile Ser Asp Thr Ile Lys Ile 
    210                 215                 220                 


Gln Gly Met Pro Asp Lys Ile Val Lys Ser Lys Leu Ser Asn Gln Ala 
225                 230                 235                 240 


Lys Ser Ala Leu Asn Ser Tyr Leu Asn Ile Asp Arg Asn His Lys Gln 
                245                 250                 255     


Gly Asn Ile Ala Glu Val Leu Ile Arg Val Lys Ser Leu Val Glu Phe 
            260                 265                 270         


Ile Leu Glu Asp Tyr Leu Asn Asn His Phe Leu Asp Val Ile Thr Tyr 
        275                 280                 285             


Lys Asp Gly Lys Pro Phe Leu Asn Ala Ser Lys Tyr Pro Glu Ile Leu 
    290                 295                 300                 


Lys Lys Phe Gln Glu Asp Ala Glu Met Arg Gly Lys Glu Tyr His Ser 
305                 310                 315                 320 


Gly Tyr Leu Ser Leu Pro Ala Tyr Ile Gly Ile Leu Lys Phe Phe Glu 
                325                 330                 335     


Pro Asn His Asp Leu Leu Lys His Ile Tyr Lys Ile Gln Glu Ile Asn 
            340                 345                 350         


Gln Asp Arg Asn Lys Val Ala His Ser Leu Gln Ala Phe Asp Arg Lys 
        355                 360                 365             


Asn Leu Lys Lys Val Ser Ser Ala Val Phe Ala Ser Lys Gln Ile Leu 
    370                 375                 380                 


Leu Ala Ser Phe Asp Ile Asp Asn His Trp Phe Ser Phe Tyr Glu Asp 
385                 390                 395                 400 


Leu Asn Gln Glu Ile Lys Lys Leu Leu 
                405                 


<210>  15
<211>  747
<212>  DNA
<213>  Lactococcus lactis

<400>  15
atgatcgtta aactccgata caaaataaac ctgccaaatt cgcttcgtac ccaaaacatc     60

gggagcactc tccatggtgt tttgatggaa ttattaccca gtgaactggt agagcacctt    120

cataacttaa gctacaatcc atttcgtcag agattaattt ttgaaaaaga gctagtcatt    180

tgggaaattg tgggcttgca caaaatggtc tcggaagagc tgttaaaact cgaaaattta    240

agggaaataa caatcaaacg tgcccaaaag actgtttcct tatccttact ctccaaagat    300

gcaatcgcag ttgatgattt ggtgaaaaaa gaaatgggac gcgaaattga cagtcgaatt    360

atctcgctta aatttacaag tccaacctca tttaaagcca atgggcatta tgacattttt    420

ccagatattc gaaaaatttt ccgttcttta atgatgaatt ttgatttttt tagtgaaaca    480

actaaaattt atgattacga ggttttgtcg tacattgaag aaaatgtcca tattgtcagc    540

tataaattga tgacaaagaa ttttcatctc gagaagataa aagtaaaagg ttttcaaggt    600

gacatgacgc tcaaagtaac tggcgcagaa cagttcgtaa aattagtctt acttatgatc    660

aaatatgcga ctttcgcagg cattggtatg aaaacaagcc ttggtatggg aggagtttcc    720

atcaatgaga gacattatct acgttga                                        747


<210>  16
<211>  248
<212>  PRT
<213>  Lactococcus lactis

<400>  16

Met Ile Val Lys Leu Arg Tyr Lys Ile Asn Leu Pro Asn Ser Leu Arg 
1               5                   10                  15      


Thr Gln Asn Ile Gly Ser Thr Leu His Gly Val Leu Met Glu Leu Leu 
            20                  25                  30          


Pro Ser Glu Leu Val Glu His Leu His Asn Leu Ser Tyr Asn Pro Phe 
        35                  40                  45              


Arg Gln Arg Leu Ile Phe Glu Lys Glu Leu Val Ile Trp Glu Ile Val 
    50                  55                  60                  


Gly Leu His Lys Met Val Ser Glu Glu Leu Leu Lys Leu Glu Asn Leu 
65                  70                  75                  80  


Arg Glu Ile Thr Ile Lys Arg Ala Gln Lys Thr Val Ser Leu Ser Leu 
                85                  90                  95      


Leu Ser Lys Asp Ala Ile Ala Val Asp Asp Leu Val Lys Lys Glu Met 
            100                 105                 110         


Gly Arg Glu Ile Asp Ser Arg Ile Ile Ser Leu Lys Phe Thr Ser Pro 
        115                 120                 125             


Thr Ser Phe Lys Ala Asn Gly His Tyr Asp Ile Phe Pro Asp Ile Arg 
    130                 135                 140                 


Lys Ile Phe Arg Ser Leu Met Met Asn Phe Asp Phe Phe Ser Glu Thr 
145                 150                 155                 160 


Thr Lys Ile Tyr Asp Tyr Glu Val Leu Ser Tyr Ile Glu Glu Asn Val 
                165                 170                 175     


His Ile Val Ser Tyr Lys Leu Met Thr Lys Asn Phe His Leu Glu Lys 
            180                 185                 190         


Ile Lys Val Lys Gly Phe Gln Gly Asp Met Thr Leu Lys Val Thr Gly 
        195                 200                 205             


Ala Glu Gln Phe Val Lys Leu Val Leu Leu Met Ile Lys Tyr Ala Thr 
    210                 215                 220                 


Phe Ala Gly Ile Gly Met Lys Thr Ser Leu Gly Met Gly Gly Val Ser 
225                 230                 235                 240 


Ile Asn Glu Arg His Tyr Leu Arg 
                245             


<210>  17
<211>  756
<212>  DNA
<213>  Lactococcus lactis

<400>  17
atgagagaca ttatctacgt tgaaaatagg tattttatca gtagtcgaga aaatgcgctc     60

agatttcatg actatattaa taaagcgacc catttcattg cttttgatga cattgatatt    120

ttagttttgg ataatgcaag aagttacttg tcaaatggtg tgattaacga ctgtttggat    180

cgaaatattt tgattttaac ttgcgataat aaacattctc ctaaagcgat tttaagcaat    240

gcttttgcta ataaaaaacg cttagaacgc ttaagaaatc aattgcaatt atcctctaag    300

tcaaagaatc gtctttggcg taaaattgtg atggcgaaaa ttaataatca ggctgatgct    360

gttaccttca cggttcaaga tggaacagtt catcgagaga taattgaact aggaaaaatg    420

gtcacagaag gagataaaga taatcgcgaa gctgtcgttg cacgaaaata ttttcggaca    480

ttatttggtg gtaattttaa gcgtggtcgt tttgatgatg tcatcaattc agcgctcaat    540

tatggctatg cacttgtgag ggctgtcatc agacgagaat tggctatctg tggttttgag    600

atgagctttg gtattcatca tatgtcaaca gaaaatcctt ttaatctctc tgatgatatg    660

attgaagttt ttcggccttt tgttgatgtg ttggtatttg agataattgt gacgaactac    720

aagcggaagt tcaaaagggc tatcaaagtt ttttaa                              756


<210>  18
<211>  251
<212>  PRT
<213>  Lactococcus lactis

<400>  18

Met Arg Asp Ile Ile Tyr Val Glu Asn Arg Tyr Phe Ile Ser Ser Arg 
1               5                   10                  15      


Glu Asn Ala Leu Arg Phe His Asp Tyr Ile Asn Lys Ala Thr His Phe 
            20                  25                  30          


Ile Ala Phe Asp Asp Ile Asp Ile Leu Val Leu Asp Asn Ala Arg Ser 
        35                  40                  45              


Tyr Leu Ser Asn Gly Val Ile Asn Asp Cys Leu Asp Arg Asn Ile Leu 
    50                  55                  60                  


Ile Leu Thr Cys Asp Asn Lys His Ser Pro Lys Ala Ile Leu Ser Asn 
65                  70                  75                  80  


Ala Phe Ala Asn Lys Lys Arg Leu Glu Arg Leu Arg Asn Gln Leu Gln 
                85                  90                  95      


Leu Ser Ser Lys Ser Lys Asn Arg Leu Trp Arg Lys Ile Val Met Ala 
            100                 105                 110         


Lys Ile Asn Asn Gln Ala Asp Ala Val Thr Phe Thr Val Gln Asp Gly 
        115                 120                 125             


Thr Val His Arg Glu Ile Ile Glu Leu Gly Lys Met Val Thr Glu Gly 
    130                 135                 140                 


Asp Lys Asp Asn Arg Glu Ala Val Val Ala Arg Lys Tyr Phe Arg Thr 
145                 150                 155                 160 


Leu Phe Gly Gly Asn Phe Lys Arg Gly Arg Phe Asp Asp Val Ile Asn 
                165                 170                 175     


Ser Ala Leu Asn Tyr Gly Tyr Ala Leu Val Arg Ala Val Ile Arg Arg 
            180                 185                 190         


Glu Leu Ala Ile Cys Gly Phe Glu Met Ser Phe Gly Ile His His Met 
        195                 200                 205             


Ser Thr Glu Asn Pro Phe Asn Leu Ser Asp Asp Met Ile Glu Val Phe 
    210                 215                 220                 


Arg Pro Phe Val Asp Val Leu Val Phe Glu Ile Ile Val Thr Asn Tyr 
225                 230                 235                 240 


Lys Arg Lys Phe Lys Arg Ala Ile Lys Val Phe 
                245                 250     


<210>  19
<211>  333
<212>  DNA
<213>  Lactococcus lactis

<400>  19
atggcgcatg aatttaaact tgtattctca gaagaatcta aacgttattt aaagaagatt     60

tacgactaca ttgttttaaa tttcttctct gaaatttctg ctcgtagaaa agttgactta    120

cttttgttag gaagtgaagt gttggagaaa attccagaat taggttttga tgtttttcaa    180

aagacaggta aaaaatttct gggaatggaa aatattcgga ttctagtgat tgaaaaatat    240

ttggcagttt atcagattga ttttgaagaa aacacaatca atatttttcg ttttttaaat    300

attaaaacca attatttacg gtacttgaga tag                                 333


<210>  20
<211>  110
<212>  PRT
<213>  Lactococcus lactis

<400>  20

Met Ala His Glu Phe Lys Leu Val Phe Ser Glu Glu Ser Lys Arg Tyr 
1               5                   10                  15      


Leu Lys Lys Ile Tyr Asp Tyr Ile Val Leu Asn Phe Phe Ser Glu Ile 
            20                  25                  30          


Ser Ala Arg Arg Lys Val Asp Leu Leu Leu Leu Gly Ser Glu Val Leu 
        35                  40                  45              


Glu Lys Ile Pro Glu Leu Gly Phe Asp Val Phe Gln Lys Thr Gly Lys 
    50                  55                  60                  


Lys Phe Leu Gly Met Glu Asn Ile Arg Ile Leu Val Ile Glu Lys Tyr 
65                  70                  75                  80  


Leu Ala Val Tyr Gln Ile Asp Phe Glu Glu Asn Thr Ile Asn Ile Phe 
                85                  90                  95      


Arg Phe Leu Asn Ile Lys Thr Asn Tyr Leu Arg Tyr Leu Arg 
            100                 105                 110 


<210>  21
<211>  150
<212>  DNA
<213>  Lactococcus lactis

<400>  21
ctttttactt tgatttttgc tatacttaag aaataacaat taaacttttt caatctacct     60

gtaggtcaat ctagcccatt gttttggtcg atatttgacc aagacaatag cgcggaaaag    120

cttactacaa acacgttttt aaagttctct                                     150


<210>  22
<211>  1114
<212>  DNA
<213>  Lactococcus lactis

<400>  22
aaatacaacc gctcctcgat aaaaggggac gagaactgca tgtttatagc cctgccggat     60

tttaagctgc gaaatacaac cgctcctcga taaaagggga cgagaacttt ccattccgtt    120

taactgctgc cagaaagatt tcatcaaata caaccgctcc tcgataaaag gggacgagaa    180

ctggttgttg tcattagctg tatcgtgaat gacgatataa aatacaaccg ctcctcgata    240

aaaggggacg agaacaactt ggaatggtaa ttcatataat tttttcataa aatacaaccg    300

ctcctcgata aaaggggacg agaactgctg gttttatttg ctcaattttt gaattgtcaa    360

aaatacaacc gctcctcgat aaaaggggac gagaactttg ttgtaaaata tttcatgttt    420

tgttttctct tttctaaata caaccgctcc tcgataaaag gggacgagaa cagagagtat    480

tcagtcatga atgaaatgat tgcaatttga aatacaaccg ctcctcgata aaaggggacg    540

agaacacaac tgttttaact ctatcctgat atataaaccc aaatacaacc gctcctcgat    600

aaaaggggac gagaacaact ttttaaggat aagaccaaca gactctgaca aatacaaccg    660

ctcctcgata aaaggggacg agaactttat ttgtggcaac aagttcagca ataatagggt    720

ttaaatacaa ccgctcctcg ataaaagggg acgagaacga acttagcaag ctattttgtt    780

tcttttcaag agccaaaata caaccgctcc tcgataaaag gggacgagaa catacgttct    840

ttgaaccaag cttcaactcc ctcggaaaat acaaccgctc ctcgataaaa ggggacgaga    900

acttctgtta atttaactcc catttgttag ttctcctaaa tacaaccgct cctcgataaa    960

aggggacgag aactttttaa aatgttgcaa atgtttagct acttcatgaa atacaaccgc   1020

tcctcgataa aaggggacga gaacatatgt cggtttgtct tttggtctaa cgtatgcaaa   1080

atacaaccgc tcctcgataa aaggggacga gaac                               1114


<210>  23
<211>  33
<212>  DNA
<213>  Lactococcus lactis

<400>  23
catatgattc aggtattgct tctacaccaa gtt                                  33


<210>  24
<211>  36
<212>  DNA
<213>  Lactococcus lactis

<400>  24
aaatacaacc gctcctcgat aaaaggggac gagaac                               36


<210>  25
<211>  35
<212>  DNA
<213>  Lactococcus lactis

<400>  25
tgcatgttta tagccctgcc ggattttaag ctgcg                                35


<210>  26
<211>  38
<212>  DNA
<213>  Lactococcus lactis

<400>  26
tttccattcc gtttaactgc tgccagaaag atttcatc                             38


<210>  27
<211>  38
<212>  DNA
<213>  Lactococcus lactis

<400>  27
tggttgttgt cattagctgt atcgtgaatg acgatata                             38


<210>  28
<211>  34
<212>  DNA
<213>  Lactococcus lactis

<400>  28
aacttggaat ggtaattcat ataatttttt cata                                 34


<210>  29
<211>  35
<212>  DNA
<213>  Lactococcus lactis

<400>  29
tgctggtttt atttgctcaa tttttgaatt gtcaa                                35


<210>  30
<211>  39
<212>  DNA
<213>  Lactococcus lactis

<400>  30
tttgttgtaa aatatttcat gttttgtttt ctcttttct                            39


<210>  31
<211>  38
<212>  DNA
<213>  Lactococcus lactis

<400>  31
agagagtatt cagtcatgaa tgaaatgatt gcaatttg                             38


<210>  32
<211>  35
<212>  DNA
<213>  Lactococcus lactis

<400>  32
acaactgttt taactctatc ctgatatata aaccc                                35


<210>  33
<211>  33
<212>  DNA
<213>  Lactococcus lactis

<400>  33
aactttttaa ggataagacc aacagactct gac                                  33


<210>  34
<211>  37
<212>  DNA
<213>  Lactococcus lactis

<400>  34
tttatttgtg gcaacaagtt cagcaataat agggttt                              37


<210>  35
<211>  37
<212>  DNA
<213>  Lactococcus lactis

<400>  35
gaacttagca agctattttg tttcttttca agagcca                              37


<210>  36
<211>  35
<212>  DNA
<213>  Lactococcus lactis

<400>  36
atacgttctt tgaaccaagc ttcaactccc tcgga                                35


<210>  37
<211>  35
<212>  DNA
<213>  Lactococcus lactis

<400>  37
ttctgttaat ttaactccca tttgttagtt ctcct                                35


<210>  38
<211>  35
<212>  DNA
<213>  Lactococcus lactis

<400>  38
tttttaaaat gttgcaaatg tttagctact tcatg                                35


<210>  39
<211>  34
<212>  DNA
<213>  Lactococcus lactis

<400>  39
atatgtcggt ttgtcttttg gtctaacgta tgca                                 34


<210>  40
<211>  35
<212>  DNA
<213>  Lactococcus lactis

<400>  40
tcattgacaa ggcgttcaag gtcatcaaaa tcatt                                35


<210>  41
<211>  37
<212>  DNA
<213>  Lactococcus lactis

<400>  41
attatcgata tagtatgttt ggttggtgta tttgtca                              37


<210>  42
<211>  36
<212>  DNA
<213>  Lactococcus lactis

<400>  42
tcagctagtg attcaaaaga tgttatcata cttctt                               36


<210>  43
<211>  41
<212>  DNA
<213>  Lactococcus lactis

<400>  43
agacaagatg ataatgaaat acgtatggta atttttccac t                         41


<210>  44
<211>  35
<212>  DNA
<213>  Lactococcus lactis

<400>  44
agcacctgct tcagcccatg tcaagataaa ttctt                                35


<210>  45
<211>  37
<212>  DNA
<213>  Lactococcus lactis

<400>  45
agtcagggct tatggttttg ttaccaaggg ataaaaa                              37


<210>  46
<211>  37
<212>  DNA
<213>  Lactococcus lactis

<400>  46
tagagtgcgt agaattttgt tttagacata gtgtttt                              37


<210>  47
<211>  34
<212>  DNA
<213>  Lactococcus lactis

<400>  47
taatgctcaa cttgcaagta aaccatttta cctt                                 34


<210>  48
<211>  35
<212>  DNA
<213>  Lactococcus lactis

<400>  48
ccaggtgtgc gtggtacatt gatgtttaga gttgc                                35


<210>  49
<211>  34
<212>  DNA
<213>  Lactococcus lactis

<400>  49
attcccaatt acaaaaatgt agtttttctt tagg                                 34


<210>  50
<211>  38
<212>  DNA
<213>  Lactococcus lactis

<400>  50
tgtagctctc ttaatgttgt caatttaata ctccctca                             38


<210>  51
<211>  38
<212>  DNA
<213>  Lactococcus lactis

<400>  51
tgaacagagg gctttaccat ttaagctata gaaccaaa                             38


<210>  52
<211>  36
<212>  DNA
<213>  Lactococcus lactis

<400>  52
cgtttgataa gtggctgaat ctctctaagt cgttgc                               36


<210>  53
<211>  38
<212>  DNA
<213>  Lactococcus lactis

<400>  53
acaatagcga agcgttttgc gtgggtttct ttgtttgt                             38


<210>  54
<211>  36
<212>  DNA
<213>  Lactococcus lactis

<400>  54
tagacatgag catcaccaga gacccgagcg ttgtca                               36


<210>  55
<211>  34
<212>  DNA
<213>  Lactococcus lactis

<400>  55
tatcaaattc ttttgcgctt gtcaagtata aact                                 34


<210>  56
<211>  37
<212>  DNA
<213>  Lactococcus lactis

<400>  56
tttagtaagt aacgttgtgc atctggcaag attgcat                              37


<210>  57
<211>  34
<212>  DNA
<213>  Lactococcus lactis

<400>  57
cgtttacrat gttattgtgt tttttattca tttt                                 34


<210>  58
<211>  36
<212>  DNA
<213>  Lactococcus lactis

<400>  58
ttcaaaacat catcgatgat tttgtttttg tctttt                               36


<210>  59
<211>  34
<212>  DNA
<213>  Lactococcus lactis

<400>  59
tattttattt atttagcatt ttttcgataa catt                                 34


<210>  60
<211>  34
<212>  DNA
<213>  Lactococcus lactis

<400>  60
gtaccgtcta acaaattcaa attcggataa atar           






