SEQUENCE LISTING

<110>  Cancilla, Mark
       Cunningham, James J.
       Flanagan, W. Michael
       Haringsma, Henry  J.
       Kenski, Denise
       Stanton, Matthew G.
       Stirdivant, Steven M.    
       Willingham, Aarron
 
<120>  RNA Interference Mediated Inhibition of Gene Expression Using 
       Short Interfering Nucleic Acids (siNA)

<130>  SIR-MIS-00134

<160>  555

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
cuuuaacaau uccugaaau                                                19


<210>  2
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
acaacagacu uuaauguaa                                                19


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  3
cuuuaacaau uccugaaaut t                                             21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  2'-O-methyl

<400>  4
auuucaggaa uuguuaaagu u                                             21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  aminohexyl phosphate inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  5
cuuuaacaau uccugaaaut t                                             21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  aminohexyl phosphate inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  6
acaacagacu uuaauguaat t                                             21


<210>  7
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  7
uuacauuaaa gucuguuguu u                                             21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  aminohexyl phosphate inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  8
cuuuaacaau uccugaaaut t                                             21


<210>  9
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  9
auuucaggaa uuguuaaagu u                                             21


<210>  10
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  10
auuucaggaa uuguuaaagu u                                             21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  11
cuuuaacaau uccugaaaut t                                             21


<210>  12
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  12
auuucaggaa uuguuaaagu u                                             21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  aminohexyl phosphate inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  13
cuuuaacaau uccugaaaut t                                             21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  aminohexyl phosphate inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  14
acaacagacu uuaauguaat t                                             21


<210>  15
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  15
uuacauuaaa gucuguuguu u                                             21


<210>  16
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  16
uuacauuaaa gucuguuguu u                                             21


<210>  17
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  17
uuacauuaaa gucuguuguu u                                             21


<210>  18
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  18
auuucaggaa uuguuaaagu u                                             21


<210>  19
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  19
auuucaggaa uuguuaaagu u                                             21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (4)..(21)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  20
autucaggaa uuguuaaagu u                                             21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (4)..(21)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  21
autucaggaa uuguuaaagu u                                             21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  22
tuacauuaaa gucuguuguu u                                             21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  23
tuacauuaaa gucuguuguu u                                             21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  aminohexyl phosphate inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  24
cuuuaacaau uccugaaaut t                                             21


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<400>  25
auuucaggaa uuguuaaagt t                                             21


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  aminohexyl phosphate inverted abasic cap

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  26
acaacagacu uuaauguaat t                                             21


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (2)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  27
tuacauuaaa gucuguugut t                                             21


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  28
uuacauuaaa gucuguugut t                                             21


<210>  29
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
auuucaggaa uuguuaaag                                                19


<210>  30
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
uuacauuaaa gucuguugu                                                19


<210>  31
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
cucucacaua caauugaaa                                                19


<210>  32
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
caguccugaa ggaauccau                                                19


<210>  33
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
gguaugacug ucaaaguaa                                                19


<210>  34
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
ccaguaaggc uucucuuaa                                                19


<210>  35
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
ggcauacauu cgucccaaa                                                19


<210>  36
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
gcuuccucaa cuauucuaa                                                19


<210>  37
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
cagcauucua acagccaau                                                19


<210>  38
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
guauaggaau gaauggaga                                                19


<210>  39
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
ccuccuauaa ugaagcaaa                                                19


<210>  40
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
cuccuauaau gaagcaaaa                                                19


<210>  41
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
cucucuaacu aacaaauuu                                                19


<210>  42
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
caagcagaag gagugcagc                                                19


<210>  43
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
augagauaau agaauuuga                                                19


<210>  44
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
cgucaaagau aucaagguu                                                19


<210>  45
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
gaauuacaga uaaugaugu                                                19


<210>  46
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
cauucagcag cuugcugca                                                19


<210>  47
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
cacaaugcau uuagaucaa                                                19


<210>  48
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
ccgugucaaa uacuuuguu                                                19


<210>  49
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
cauagaagcc aguauagga                                                19


<210>  50
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
acaaagcaau cauuugauu                                                19


<210>  51
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
caagugucau cacacugaa                                                19


<210>  52
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52
gucaucacac ugaauacca                                                19


<210>  53
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
ucaucacacu gaauaccaa                                                19


<210>  54
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
caguacaaau uagagggaa                                                19


<210>  55
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
gaacuuaaug gaaauacca                                                19


<210>  56
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
uugaucacaa guucagcuu                                                19


<210>  57
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
gagaaaucaa gauuaauca                                                19


<210>  58
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
cuuuguagac uacuauaaa                                                19


<210>  59
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
cguugauaac ccaaaugga                                                19


<210>  60
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
gaagaugcgu gacauguau                                                19


<210>  61
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61
aguggaggua uucuucgaa                                                19


<210>  62
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62
cauugaaccc aaauuugau                                                19


<210>  63
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63
gcaauaacug uuugguauu                                                19


<210>  64
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64
cagucagcaa agacgucua                                                19


<210>  65
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65
gcaguaccca cgucaccua                                                19


<210>  66
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66
gagacaccug ccugguauu                                                19


<210>  67
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67
gaaacaaggg cccuuugua                                                19


<210>  68
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68
caaggagccc ggcugcgaa                                                19


<210>  69
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69
cgggaagcug ggcagcuac                                                19


<210>  70
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70
ggacgaaagc caugguugc                                                19


<210>  71
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71
aagccauggu ugcuuguua                                                19


<210>  72
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72
gauggaagau gugugacau                                                19


<210>  73
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73
gaugugugac auguauaua                                                19


<210>  74
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74
gacugggaug ccaagguaa                                                19


<210>  75
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75
gcccaguuug cugacauug                                                19


<210>  76
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76
uugcugacau ugaacccaa                                                19


<210>  77
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77
ucgcaacccu caugaagua                                                19


<210>  78
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78
cucaugaagu acaaccagc                                                19


<210>  79
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79
gugugagggu ugaacucaa                                                19


<210>  80
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80
augcuacaag guacgcaau                                                19


<210>  81
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81
aagguacgca auaacuguu                                                19


<210>  82
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82
ggugugaggg uugaacuca                                                19


<210>  83
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83
ugaaggcugg guaccuuug                                                19


<210>  84
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84
aucugucauc aaauugagu                                                19


<210>  85
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85
ucugucauca aauugagua                                                19


<210>  86
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86
cugucaucaa auugaguau                                                19


<210>  87
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87
gucaucaaau ugaguauua                                                19


<210>  88
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88
ucaucaaauu gaguauuau                                                19


<210>  89
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89
uggagacuuc aauuugcca                                                19


<210>  90
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90
uggaugaagg cuggguacc                                                19


<210>  91
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91
ggaugaaggc uggguaccu                                                19


<210>  92
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92
gaugaaggcu ggguaccuu                                                19


<210>  93
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  93
augaaggcug gguaccuuu                                                19


<210>  94
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  94
aaggcugggu accuuugga                                                19


<210>  95
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  95
ggcuggguac cuuuggaaa                                                19


<210>  96
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  96
cuggguaccu uuggaaaca                                                19


<210>  97
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  97
gcagaccacu cccugaagu                                                19


<210>  98
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  98
ccugaaguga cggaugagu                                                19


<210>  99
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  99
aaaucauggu gaaauaaaa                                                19


<210>  100
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  100
ugcaaauaau gguaaccua                                                19


<210>  101
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  101
gcaaauaaug guaaccuac                                                19


<210>  102
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  102
auaaugguaa ccuacuguu                                                19


<210>  103
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  103
gguaaccuac uguuaagga                                                19


<210>  104
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  104
aaguacuaga aggacaugc                                                19


<210>  105
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  105
aaggaagagg acaguuuca                                                19


<210>  106
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  106
ggaggacaag auuugauga                                                19


<210>  107
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  107
cagagaagaa cccgcauca                                                19


<210>  108
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  108
gagaagaacc cgcaucaaa                                                19


<210>  109
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  109
cuacacaaau cagcgauuu                                                19


<210>  110
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  110
ggacuucucu caauuuucu                                                19


<210>  111
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  111
cucucacaua caauugaaau u                                             21


<210>  112
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  112
uuucaauugu augugagagu u                                             21


<210>  113
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  113
caguccugaa ggaauccauu u                                             21


<210>  114
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  114
auggauuccu ucaggacugu u                                             21


<210>  115
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  115
gguaugacug ucaaaguaau u                                             21


<210>  116
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  116
uuacuuugac agucauaccu u                                             21


<210>  117
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  117
ccaguaaggc uucucuuaau u                                             21


<210>  118
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  118
uuaagagaag ccuuacuggu u                                             21


<210>  119
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  119
ggcauacauu cgucccaaau u                                             21


<210>  120
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  120
uuugggacga auguaugccu u                                             21


<210>  121
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  121
gcuuccucaa cuauucuaau u                                             21


<210>  122
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  122
uuagaauagu ugaggaagcu u                                             21


<210>  123
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  123
cagcauucua acagccaauu u                                             21


<210>  124
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  124
auuggcuguu agaaugcugu u                                             21


<210>  125
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  125
guauaggaau gaauggagau u                                             21


<210>  126
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  126
ucuccauuca uuccuauacu u                                             21


<210>  127
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  127
ccuccuauaa ugaagcaaau u                                             21


<210>  128
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  128
uuugcuucau uauaggaggu u                                             21


<210>  129
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  129
cuccuauaau gaagcaaaau u                                             21


<210>  130
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  130
uuuugcuuca uuauaggagu u                                             21


<210>  131
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  131
cucucuaacu aacaaauuuu u                                             21


<210>  132
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  132
aaauuuguua guuagagagu u                                             21


<210>  133
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  133
caagcagaag gagugcagcu u                                             21


<210>  134
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  134
gcugcacucc uucugcuugu u                                             21


<210>  135
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  135
augagauaau agaauuugau u                                             21


<210>  136
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  136
ucaaauucua uuaucucauu u                                             21


<210>  137
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  137
cgucaaagau aucaagguuu u                                             21


<210>  138
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  138
aaccuugaua ucuuugacgu u                                             21


<210>  139
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  139
gaauuacaga uaaugauguu u                                             21


<210>  140
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  140
acaucauuau cuguaauucu u                                             21


<210>  141
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  141
cauucagcag cuugcugcau u                                             21


<210>  142
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  142
ugcagcaagc ugcugaaugu u                                             21


<210>  143
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  143
cacaaugcau uuagaucaau u                                             21


<210>  144
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  144
uugaucuaaa ugcauugugu u                                             21


<210>  145
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  145
ccgugucaaa uacuuuguuu u                                             21


<210>  146
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  146
aacaaaguau uugacacggu u                                             21


<210>  147
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  147
cauagaagcc aguauaggau u                                             21


<210>  148
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  148
uccuauacug gcuucuaugu u                                             21


<210>  149
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  149
cuuuaacaau uccugaaauu u                                             21


<210>  150
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  150
auuucaggaa uuguuaaagu u                                             21


<210>  151
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  151
acaaagcaau cauuugauuu u                                             21


<210>  152
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  152
aaucaaauga uugcuuuguu u                                             21


<210>  153
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  153
caagugucau cacacugaau u                                             21


<210>  154
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  154
uucaguguga ugacacuugu u                                             21


<210>  155
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  155
gucaucacac ugaauaccau u                                             21


<210>  156
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  156
ugguauucag ugugaugacu u                                             21


<210>  157
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  157
ucaucacacu gaauaccaau u                                             21


<210>  158
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  158
uugguauuca gugugaugau u                                             21


<210>  159
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  159
caguacaaau uagagggaau u                                             21


<210>  160
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  160
uucccucuaa uuuguacugu u                                             21


<210>  161
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  161
gaacuuaaug gaaauaccau u                                             21


<210>  162
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  162
ugguauuucc auuaaguucu u                                             21


<210>  163
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  163
uugaucacaa guucagcuuu u                                             21


<210>  164
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  164
aagcugaacu ugugaucaau u                                             21


<210>  165
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  165
gagaaaucaa gauuaaucau u                                             21


<210>  166
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  166
ugauuaaucu ugauuucucu u                                             21


<210>  167
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  167
cuuuguagac uacuauaaau u                                             21


<210>  168
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  168
uuuauaguag ucuacaaagu u                                             21


<210>  169
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  169
cucucacaua caauugaaat t                                             21


<210>  170
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  170
uuucaauugu augugagagu u                                             21


<210>  171
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  171
caguccugaa ggaauccaut t                                             21


<210>  172
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  172
auggauuccu ucaggacugu u                                             21


<210>  173
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  173
gguaugacug ucaaaguaat t                                             21


<210>  174
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  174
uuacuuugac agucauaccu u                                             21


<210>  175
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  175
ccaguaaggc uucucuuaat t                                             21


<210>  176
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  176
uuaagagaag ccuuacuggu u                                             21


<210>  177
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  177
ggcauacauu cgucccaaat t                                             21


<210>  178
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  178
uuugggacga auguaugccu u                                             21


<210>  179
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  179
gcuuccucaa cuauucuaat t                                             21


<210>  180
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  180
uuagaauagu ugaggaagcu u                                             21


<210>  181
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  181
cagcauucua acagccaaut t                                             21


<210>  182
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  182
auuggcuguu agaaugcugu u                                             21


<210>  183
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  183
guauaggaau gaauggagat t                                             21


<210>  184
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  184
ucuccauuca uuccuauacu u                                             21


<210>  185
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  185
ccuccuauaa ugaagcaaat t                                             21


<210>  186
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  186
uuugcuucau uauaggaggu u                                             21


<210>  187
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  187
cuccuauaau gaagcaaaat t                                             21


<210>  188
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  188
uuuugcuuca uuauaggagu u                                             21


<210>  189
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  189
cucucuaacu aacaaauuut t                                             21


<210>  190
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  190
aaauuuguua guuagagagu u                                             21


<210>  191
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  191
caagcagaag gagugcagct t                                             21


<210>  192
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  192
gcugcacucc uucugcuugu u                                             21


<210>  193
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  193
augagauaau agaauuugat t                                             21


<210>  194
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  194
ucaaauucua uuaucucauu u                                             21


<210>  195
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  195
cgucaaagau aucaagguut t                                             21


<210>  196
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  196
aaccuugaua ucuuugacgu u                                             21


<210>  197
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  197
gaauuacaga uaaugaugut t                                             21


<210>  198
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  198
acaucauuau cuguaauucu u                                             21


<210>  199
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  199
cauucagcag cuugcugcat t                                             21


<210>  200
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  200
ugcagcaagc ugcugaaugu u                                             21


<210>  201
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  201
cacaaugcau uuagaucaat t                                             21


<210>  202
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  202
uugaucuaaa ugcauugugu u                                             21


<210>  203
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  203
ccgugucaaa uacuuuguut t                                             21


<210>  204
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  204
aacaaaguau uugacacggu u                                             21


<210>  205
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  205
cauagaagcc aguauaggat t                                             21


<210>  206
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  206
uccuauacug gcuucuaugu u                                             21


<210>  207
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  207
acaaagcaau cauuugauut t                                             21


<210>  208
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  208
aaucaaauga uugcuuuguu u                                             21


<210>  209
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  209
caagugucau cacacugaat t                                             21


<210>  210
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  210
uucaguguga ugacacuugu u                                             21


<210>  211
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  211
gucaucacac ugaauaccat t                                             21


<210>  212
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  212
ugguauucag ugugaugacu u                                             21


<210>  213
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  213
ucaucacacu gaauaccaat t                                             21


<210>  214
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  214
uugguauuca gugugaugau u                                             21


<210>  215
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  215
caguacaaau uagagggaat t                                             21


<210>  216
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  216
uucccucuaa uuuguacugu u                                             21


<210>  217
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  217
gaacuuaaug gaaauaccat t                                             21


<210>  218
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  218
ugguauuucc auuaaguucu u                                             21


<210>  219
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  219
uugaucacaa guucagcuut t                                             21


<210>  220
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  220
aagcugaacu ugugaucaau u                                             21


<210>  221
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  221
gagaaaucaa gauuaaucat t                                             21


<210>  222
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  222
ugauuaaucu ugauuucucu u                                             21


<210>  223
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  223
cuuuguagac uacuauaaat t                                             21


<210>  224
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  224
uuuauaguag ucuacaaagu u                                             21


<210>  225
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  225
cguugauaac ccaaauggau u                                             21


<210>  226
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  226
uccauuuggg uuaucaacgu u                                             21


<210>  227
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  227
gaagaugcgu gacauguauu u                                             21


<210>  228
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  228
auacauguca cgcaucuucu u                                             21


<210>  229
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  229
aguggaggua uucuucgaau u                                             21


<210>  230
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  230
uucgaagaau accuccacuu u                                             21


<210>  231
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  231
cauugaaccc aaauuugauu u                                             21


<210>  232
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  232
aucaaauuug gguucaaugu u                                             21


<210>  233
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  233
gcaauaacug uuugguauuu u                                             21


<210>  234
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  234
aauaccaaac aguuauugcu u                                             21


<210>  235
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  235
cagucagcaa agacgucuau u                                             21


<210>  236
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  236
uagacgucuu ugcugacugu u                                             21


<210>  237
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  237
gcaguaccca cgucaccuau u                                             21


<210>  238
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  238
uaggugacgu ggguacugcu u                                             21


<210>  239
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  239
gagacaccug ccugguauuu u                                             21


<210>  240
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  240
aauaccaggc aggugucucu u                                             21


<210>  241
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  241
gaaacaaggg cccuuuguau u                                             21


<210>  242
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  242
uacaaagggc ccuuguuucu u                                             21


<210>  243
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  243
caaggagccc ggcugcgaau u                                             21


<210>  244
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  244
uucgcagccg ggcuccuugu u                                             21


<210>  245
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  245
cgggaagcug ggcagcuacu u                                             21


<210>  246
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  246
guagcugccc agcuucccgu u                                             21


<210>  247
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  247
ggacgaaagc caugguugcu u                                             21


<210>  248
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  248
gcaaccaugg cuuucguccu u                                             21


<210>  249
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  249
aagccauggu ugcuuguuau u                                             21


<210>  250
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  250
uaacaagcaa ccauggcuuu u                                             21


<210>  251
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  251
gauggaagau gugugacauu u                                             21


<210>  252
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  252
augucacaca ucuuccaucu u                                             21


<210>  253
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  253
gaugugugac auguauauau u                                             21


<210>  254
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  254
uauauacaug ucacacaucu u                                             21


<210>  255
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  255
gacugggaug ccaagguaau u                                             21


<210>  256
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  256
uuaccuuggc aucccagucu u                                             21


<210>  257
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  257
gcccaguuug cugacauugu u                                             21


<210>  258
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  258
caaugucagc aaacugggcu u                                             21


<210>  259
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  259
uugcugacau ugaacccaau u                                             21


<210>  260
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  260
uuggguucaa ugucagcaau u                                             21


<210>  261
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  261
ucgcaacccu caugaaguau u                                             21


<210>  262
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  262
uacuucauga ggguugcgau u                                             21


<210>  263
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  263
cucaugaagu acaaccagcu u                                             21


<210>  264
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  264
gcugguugua cuucaugagu u                                             21


<210>  265
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  265
gugugagggu ugaacucaau u                                             21


<210>  266
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  266
uugaguucaa cccucacacu u                                             21


<210>  267
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  267
augcuacaag guacgcaauu u                                             21


<210>  268
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  268
auugcguacc uuguagcauu u                                             21


<210>  269
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  269
aagguacgca auaacuguuu u                                             21


<210>  270
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  270
aacaguuauu gcguaccuuu u                                             21


<210>  271
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  271
ggugugaggg uugaacucau u                                             21


<210>  272
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  272
ugaguucaac ccucacaccu u                                             21


<210>  273
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  273
cguugauaac ccaaauggat t                                             21


<210>  274
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  274
uccauuuggg uuaucaacgu u                                             21


<210>  275
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  275
gaagaugcgu gacauguaut t                                             21


<210>  276
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  276
auacauguca cgcaucuucu u                                             21


<210>  277
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  277
aguggaggua uucuucgaat t                                             21


<210>  278
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  278
uucgaagaau accuccacuu u                                             21


<210>  279
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  279
cauugaaccc aaauuugaut t                                             21


<210>  280
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  280
aucaaauuug gguucaaugu u                                             21


<210>  281
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  281
gcaauaacug uuugguauut t                                             21


<210>  282
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  282
aauaccaaac aguuauugcu u                                             21


<210>  283
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  283
cagucagcaa agacgucuat t                                             21


<210>  284
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  284
uagacgucuu ugcugacugu u                                             21


<210>  285
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  285
gcaguaccca cgucaccuat t                                             21


<210>  286
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  286
uaggugacgu ggguacugcu u                                             21


<210>  287
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  287
gagacaccug ccugguauut t                                             21


<210>  288
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  288
aauaccaggc aggugucucu u                                             21


<210>  289
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  289
gaaacaaggg cccuuuguat t                                             21


<210>  290
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  290
uacaaagggc ccuuguuucu u                                             21


<210>  291
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  291
caaggagccc ggcugcgaat t                                             21


<210>  292
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  292
uucgcagccg ggcuccuugu u                                             21


<210>  293
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  293
cgggaagcug ggcagcuact t                                             21


<210>  294
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  294
guagcugccc agcuucccgu u                                             21


<210>  295
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  295
ggacgaaagc caugguugct t                                             21


<210>  296
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  296
gcaaccaugg cuuucguccu u                                             21


<210>  297
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  297
aagccauggu ugcuuguuat t                                             21


<210>  298
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  298
uaacaagcaa ccauggcuuu u                                             21


<210>  299
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  299
gauggaagau gugugacaut t                                             21


<210>  300
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  300
augucacaca ucuuccaucu u                                             21


<210>  301
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  301
gaugugugac auguauauat t                                             21


<210>  302
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  302
uauauacaug ucacacaucu u                                             21


<210>  303
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  303
gacugggaug ccaagguaat t                                             21


<210>  304
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  304
uuaccuuggc aucccagucu u                                             21


<210>  305
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  305
gcccaguuug cugacauugt t                                             21


<210>  306
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  306
caaugucagc aaacugggcu u                                             21


<210>  307
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  307
uugcugacau ugaacccaat t                                             21


<210>  308
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  308
uuggguucaa ugucagcaau u                                             21


<210>  309
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  309
ucgcaacccu caugaaguat t                                             21


<210>  310
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  310
uacuucauga ggguugcgau u                                             21


<210>  311
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  311
cucaugaagu acaaccagct t                                             21


<210>  312
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  312
gcugguugua cuucaugagu u                                             21


<210>  313
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  313
gugugagggu ugaacucaat t                                             21


<210>  314
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  314
uugaguucaa cccucacacu u                                             21


<210>  315
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  315
augcuacaag guacgcaaut t                                             21


<210>  316
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  316
auugcguacc uuguagcauu u                                             21


<210>  317
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  317
aagguacgca auaacuguut t                                             21


<210>  318
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  318
aacaguuauu gcguaccuuu u                                             21


<210>  319
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  319
ggugugaggg uugaacucat t                                             21


<210>  320
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  320
ugaguucaac ccucacaccu u                                             21


<210>  321
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  321
ugaaggcugg guaccuuugu u                                             21


<210>  322
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  322
caaagguacc cagccuucau u                                             21


<210>  323
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  323
aucugucauc aaauugaguu u                                             21


<210>  324
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  324
acucaauuug augacagauu u                                             21


<210>  325
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  325
ucugucauca aauugaguau u                                             21


<210>  326
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  326
uacucaauuu gaugacagau u                                             21


<210>  327
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  327
cugucaucaa auugaguauu u                                             21


<210>  328
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  328
auacucaauu ugaugacagu u                                             21


<210>  329
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  329
gucaucaaau ugaguauuau u                                             21


<210>  330
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  330
uaauacucaa uuugaugacu u                                             21


<210>  331
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  331
ucaucaaauu gaguauuauu u                                             21


<210>  332
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  332
auaauacuca auuugaugau u                                             21


<210>  333
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  333
uggagacuuc aauuugccau u                                             21


<210>  334
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  334
uggcaaauug aagucuccau u                                             21


<210>  335
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  335
acaacagacu uuaauguaau u                                             21


<210>  336
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  336
uuacauuaaa gucuguuguu u                                             21


<210>  337
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  337
uggaugaagg cuggguaccu u                                             21


<210>  338
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  338
gguacccagc cuucauccau u                                             21


<210>  339
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  339
ggaugaaggc uggguaccuu u                                             21


<210>  340
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  340
agguacccag ccuucauccu u                                             21


<210>  341
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  341
gaugaaggcu ggguaccuuu u                                             21


<210>  342
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  342
aagguaccca gccuucaucu u                                             21


<210>  343
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  343
augaaggcug gguaccuuuu u                                             21


<210>  344
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  344
aaagguaccc agccuucauu u                                             21


<210>  345
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  345
aaggcugggu accuuuggau u                                             21


<210>  346
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  346
uccaaaggua cccagccuuu u                                             21


<210>  347
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  347
ggcuggguac cuuuggaaau u                                             21


<210>  348
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  348
uuuccaaagg uacccagccu u                                             21


<210>  349
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  349
cuggguaccu uuggaaacau u                                             21


<210>  350
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  350
uguuuccaaa gguacccagu u                                             21


<210>  351
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  351
gcagaccacu cccugaaguu u                                             21


<210>  352
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  352
acuucaggga guggucugcu u                                             21


<210>  353
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  353
ccugaaguga cggaugaguu u                                             21


<210>  354
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  354
acucauccgu cacuucaggu u                                             21


<210>  355
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  355
aaaucauggu gaaauaaaau u                                             21


<210>  356
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  356
uuuuauuuca ccaugauuuu u                                             21


<210>  357
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  357
ugcaaauaau gguaaccuau u                                             21


<210>  358
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  358
uagguuacca uuauuugcau u                                             21


<210>  359
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  359
gcaaauaaug guaaccuacu u                                             21


<210>  360
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  360
guagguuacc auuauuugcu u                                             21


<210>  361
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  361
auaaugguaa ccuacuguuu u                                             21


<210>  362
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  362
aacaguaggu uaccauuauu u                                             21


<210>  363
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  363
gguaaccuac uguuaaggau u                                             21


<210>  364
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  364
uccuuaacag uagguuaccu u                                             21


<210>  365
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  365
aaguacuaga aggacaugcu u                                             21


<210>  366
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  366
gcauguccuu cuaguacuuu u                                             21


<210>  367
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  367
aaggaagagg acaguuucau u                                             21


<210>  368
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  368
ugaaacuguc cucuuccuuu u                                             21


<210>  369
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  369
ggaggacaag auuugaugau u                                             21


<210>  370
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  370
ucaucaaauc uuguccuccu u                                             21


<210>  371
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  371
cagagaagaa cccgcaucau u                                             21


<210>  372
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  372
ugaugcgggu ucuucucugu u                                             21


<210>  373
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  373
gagaagaacc cgcaucaaau u                                             21


<210>  374
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  374
uuugaugcgg guucuucucu u                                             21


<210>  375
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  375
ugaaggcugg guaccuuugt t                                             21


<210>  376
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  376
caaagguacc cagccuucau u                                             21


<210>  377
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  377
aucugucauc aaauugagut t                                             21


<210>  378
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  378
acucaauuug augacagauu u                                             21


<210>  379
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  379
ucugucauca aauugaguat t                                             21


<210>  380
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  380
uacucaauuu gaugacagau u                                             21


<210>  381
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  381
cugucaucaa auugaguaut t                                             21


<210>  382
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  382
auacucaauu ugaugacagu u                                             21


<210>  383
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  383
gucaucaaau ugaguauuat t                                             21


<210>  384
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  384
uaauacucaa uuugaugacu u                                             21


<210>  385
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  385
ucaucaaauu gaguauuaut t                                             21


<210>  386
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  386
auaauacuca auuugaugau u                                             21


<210>  387
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  387
uggagacuuc aauuugccat t                                             21


<210>  388
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  388
uggcaaauug aagucuccau u                                             21


<210>  389
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  389
acaacagacu uuaauguaat t                                             21


<210>  390
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  390
uggaugaagg cuggguacct t                                             21


<210>  391
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  391
gguacccagc cuucauccau u                                             21


<210>  392
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  392
ggaugaaggc uggguaccut t                                             21


<210>  393
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  393
agguacccag ccuucauccu u                                             21


<210>  394
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  394
gaugaaggcu ggguaccuut t                                             21


<210>  395
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  395
aagguaccca gccuucaucu u                                             21


<210>  396
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  396
augaaggcug gguaccuuut t                                             21


<210>  397
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  397
aaagguaccc agccuucauu u                                             21


<210>  398
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  398
aaggcugggu accuuuggat t                                             21


<210>  399
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  399
uccaaaggua cccagccuuu u                                             21


<210>  400
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  400
ggcuggguac cuuuggaaat t                                             21


<210>  401
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  401
uuuccaaagg uacccagccu u                                             21


<210>  402
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  402
cuggguaccu uuggaaacat t                                             21


<210>  403
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  403
uguuuccaaa gguacccagu u                                             21


<210>  404
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  404
gcagaccacu cccugaagut t                                             21


<210>  405
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  405
acuucaggga guggucugcu u                                             21


<210>  406
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  406
ccugaaguga cggaugagut t                                             21


<210>  407
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  407
acucauccgu cacuucaggu u                                             21


<210>  408
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  408
aaaucauggu gaaauaaaat t                                             21


<210>  409
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  409
uuuuauuuca ccaugauuuu u                                             21


<210>  410
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  410
ugcaaauaau gguaaccuat t                                             21


<210>  411
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  411
uagguuacca uuauuugcau u                                             21


<210>  412
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  412
gcaaauaaug guaaccuact t                                             21


<210>  413
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  413
guagguuacc auuauuugcu u                                             21


<210>  414
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  414
auaaugguaa ccuacuguut t                                             21


<210>  415
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  415
aacaguaggu uaccauuauu u                                             21


<210>  416
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  416
gguaaccuac uguuaaggat t                                             21


<210>  417
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  417
uccuuaacag uagguuaccu u                                             21


<210>  418
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  418
aaguacuaga aggacaugct t                                             21


<210>  419
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  419
gcauguccuu cuaguacuuu u                                             21


<210>  420
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  420
aaggaagagg acaguuucat t                                             21


<210>  421
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  421
ugaaacuguc cucuuccuuu u                                             21


<210>  422
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  422
ggaggacaag auuugaugat t                                             21


<210>  423
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  423
ucaucaaauc uuguccuccu u                                             21


<210>  424
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  424
cagagaagaa cccgcaucat t                                             21


<210>  425
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  425
ugaugcgggu ucuucucugu u                                             21


<210>  426
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  426
gagaagaacc cgcaucaaat t                                             21


<210>  427
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  427
uuugaugcgg guucuucucu u                                             21


<210>  428
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  428
uagcgacuaa acacaucaau u                                             21


<210>  429
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  429
uugauguguu uagucgcuau u                                             21


<210>  430
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-O-methyl

<400>  430
uagcgacuaa acacaucaau u                                             21


<210>  431
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<400>  431
uugauguguu uagucgcuau u                                             21


<210>  432
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<400>  432
uagcgacuaa acacaucaau u                                             21


<210>  433
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<400>  433
uugauguguu uagucgcuau u                                             21


<210>  434
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<400>  434
uagcgacuaa acacaucaau u                                             21


<210>  435
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<400>  435
uugauguguu uagucgcuau u                                             21


<210>  436
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<400>  436
uugauguguu uagucgcuau u                                             21


<210>  437
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<400>  437
uagcgacuaa acacaucaau u                                             21


<210>  438
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<400>  438
uagcgacuaa acacaucaau u                                             21


<210>  439
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<400>  439
uugauguguu uagucgcuau u                                             21


<210>  440
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<400>  440
uagcgacuaa acacaucaau u                                             21


<210>  441
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<400>  441
uugauguguu uagucgcuau u                                             21


<210>  442
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<400>  442
uagcgacuaa acacaucaau u                                             21


<210>  443
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<400>  443
uugauguguu uagucgcuau u                                             21


<210>  444
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<400>  444
uugauguguu uagucgcuau u                                             21


<210>  445
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<400>  445
uagcgacuaa acacaucaau u                                             21


<210>  446
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  446
aaaucgcuga uuuguguagu u                                             21


<210>  447
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  447
cuacacaaau cagcgauuuu u                                             21


<210>  448
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<400>  448
aaaucgcuga uuuguguagu u                                             21


<210>  449
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<400>  449
cuacacaaau cagcgauuuu u                                             21


<210>  450
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<400>  450
aaaucgcuga uuuguguagu u                                             21


<210>  451
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<400>  451
cuacacaaau cagcgauuuu u                                             21


<210>  452
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<400>  452
cuacacaaau cagcgauuuu u                                             21


<210>  453
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<400>  453
aaaucgcuga uuuguguagu u                                             21


<210>  454
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<400>  454
aaaucgcuga uuuguguagu u                                             21


<210>  455
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-O-methyl

<400>  455
cuacacaaau cagcgauuuu u                                             21


<210>  456
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<400>  456
aaaucgcuga uuuguguagu u                                             21


<210>  457
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<400>  457
cuacacaaau cagcgauuuu u                                             21


<210>  458
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<400>  458
aaaucgcuga uuuguguagu u                                             21


<210>  459
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<400>  459
cuacacaaau cagcgauuuu u                                             21


<210>  460
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<400>  460
cuacacaaau cagcgauuuu u                                             21


<210>  461
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<400>  461
aaaucgcuga uuuguguagu u                                             21


<210>  462
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<400>  462
aaaucgcuga uuuguguagu u                                             21


<210>  463
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<400>  463
cuacacaaau cagcgauuuu u                                             21


<210>  464
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  464
auugguauuc agugugauga cac                                           23


<210>  465
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  465
gucaucacac ugaauaccaa u                                             21


<210>  466
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  2'-O-methyl

<400>  466
auugguauuc agugugauga cac                                           23


<210>  467
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  2'-O-methyl

<400>  467
gucaucacac ugaauaccaa u                                             21


<210>  468
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<400>  468
gucaucacac ugaauaccaa u                                             21


<210>  469
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<400>  469
auugguauuc agugugauga cac                                           23


<210>  470
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'-O-methyl

<400>  470
auugguauuc agugugauga cac                                           23


<210>  471
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<400>  471
gucaucacac ugaauaccaa u                                             21


<210>  472
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<400>  472
auugguauuc agugugauga cac                                           23


<210>  473
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  2'-O-methyl

<400>  473
gucaucacac ugaauaccaa u                                             21


<210>  474
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  474
ccugaagaga guuaaaagau u                                             21


<210>  475
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  475
ucuuuuaacu cucuucaggt t                                             21


<210>  476
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  476
uuucaauugu augugagag                                                19


<210>  477
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  477
auggauuccu ucaggacug                                                19


<210>  478
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  478
uuacuuugac agucauacc                                                19


<210>  479
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  479
uuaagagaag ccuuacugg                                                19


<210>  480
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  480
uuugggacga auguaugcc                                                19


<210>  481
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  481
uuagaauagu ugaggaagc                                                19


<210>  482
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  482
auuggcuguu agaaugcug                                                19


<210>  483
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  483
ucuccauuca uuccuauac                                                19


<210>  484
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  484
uuugcuucau uauaggagg                                                19


<210>  485
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  485
uuuugcuuca uuauaggag                                                19


<210>  486
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  486
aaauuuguua guuagagag                                                19


<210>  487
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  487
gcugcacucc uucugcuug                                                19


<210>  488
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  488
ucaaauucua uuaucucau                                                19


<210>  489
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  489
aaccuugaua ucuuugacg                                                19


<210>  490
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  490
acaucauuau cuguaauuc                                                19


<210>  491
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  491
ugcagcaagc ugcugaaug                                                19


<210>  492
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  492
uugaucuaaa ugcauugug                                                19


<210>  493
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  493
aacaaaguau uugacacgg                                                19


<210>  494
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  494
uccuauacug gcuucuaug                                                19


<210>  495
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  495
aaucaaauga uugcuuugu                                                19


<210>  496
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  496
uucaguguga ugacacuug                                                19


<210>  497
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  497
ugguauucag ugugaugac                                                19


<210>  498
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  498
uugguauuca gugugauga                                                19


<210>  499
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  499
uucccucuaa uuuguacug                                                19


<210>  500
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  500
ugguauuucc auuaaguuc                                                19


<210>  501
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  501
aagcugaacu ugugaucaa                                                19


<210>  502
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  502
ugauuaaucu ugauuucuc                                                19


<210>  503
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  503
uuuauaguag ucuacaaag                                                19


<210>  504
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  504
uccauuuggg uuaucaacg                                                19


<210>  505
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  505
auacauguca cgcaucuuc                                                19


<210>  506
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  506
uucgaagaau accuccacu                                                19


<210>  507
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  507
aucaaauuug gguucaaug                                                19


<210>  508
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  508
aauaccaaac aguuauugc                                                19


<210>  509
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  509
uagacgucuu ugcugacug                                                19


<210>  510
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  510
uaggugacgu ggguacugc                                                19


<210>  511
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  511
aauaccaggc aggugucuc                                                19


<210>  512
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  512
uacaaagggc ccuuguuuc                                                19


<210>  513
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  513
uucgcagccg ggcuccuug                                                19


<210>  514
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  514
guagcugccc agcuucccg                                                19


<210>  515
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  515
gcaaccaugg cuuucgucc                                                19


<210>  516
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  516
uaacaagcaa ccauggcuu                                                19


<210>  517
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  517
augucacaca ucuuccauc                                                19


<210>  518
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  518
uauauacaug ucacacauc                                                19


<210>  519
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  519
uuaccuuggc aucccaguc                                                19


<210>  520
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  520
caaugucagc aaacugggc                                                19


<210>  521
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  521
uuggguucaa ugucagcaa                                                19


<210>  522
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  522
uacuucauga ggguugcga                                                19


<210>  523
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  523
gcugguugua cuucaugag                                                19


<210>  524
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  524
uugaguucaa cccucacac                                                19


<210>  525
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  525
auugcguacc uuguagcau                                                19


<210>  526
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  526
aacaguuauu gcguaccuu                                                19


<210>  527
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  527
ugaguucaac ccucacacc                                                19


<210>  528
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  528
caaagguacc cagccuuca                                                19


<210>  529
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  529
acucaauuug augacagau                                                19


<210>  530
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  530
uacucaauuu gaugacaga                                                19


<210>  531
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  531
auacucaauu ugaugacag                                                19


<210>  532
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  532
uaauacucaa uuugaugac                                                19


<210>  533
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  533
auaauacuca auuugauga                                                19


<210>  534
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  534
uggcaaauug aagucucca                                                19


<210>  535
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  535
gguacccagc cuucaucca                                                19


<210>  536
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  536
agguacccag ccuucaucc                                                19


<210>  537
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  537
aagguaccca gccuucauc                                                19


<210>  538
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  538
aaagguaccc agccuucau                                                19


<210>  539
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  539
uccaaaggua cccagccuu                                                19


<210>  540
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  540
uuuccaaagg uacccagcc                                                19


<210>  541
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  541
uguuuccaaa gguacccag                                                19


<210>  542
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  542
acuucaggga guggucugc                                                19


<210>  543
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  543
acucauccgu cacuucagg                                                19


<210>  544
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  544
uuuuauuuca ccaugauuu                                                19


<210>  545
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  545
uagguuacca uuauuugca                                                19


<210>  546
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  546
guagguuacc auuauuugc                                                19


<210>  547
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  547
aacaguaggu uaccauuau                                                19


<210>  548
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  548
uccuuaacag uagguuacc                                                19


<210>  549
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  549
gcauguccuu cuaguacuu                                                19


<210>  550
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  550
ugaaacuguc cucuuccuu                                                19


<210>  551
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  551
ucaucaaauc uuguccucc                                                19


<210>  552
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  552
ugaugcgggu ucuucucug                                                19


<210>  553
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  553
uuugaugcgg guucuucuc                                                19


<210>  554
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  554
aaaucgcuga uuuguguag                                                19


<210>  555
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  555
agaaaauuga gagaagucc                                                19



