                         SEQUENCE LISTING

<110>  Amgen Inc.
 
<120>  DKK1 ANTIBODIES AND METHODS OF USE

<130>  A-1574-WO-PCT

<150>  61/407,128
<151>  2010-10-27

<160>  244   

<170>  PatentIn version 3.5

<210>  1
<211>  798
<212>  DNA
<213>  Homo sapiens

<400>  1
atgatggctc tgggcgcagc gggagctacc cgggtctttg tcgcgatggt agcggcggct       60

ctcggcggcc accctctgct gggagtgagc gccaccttga actcggttct caattccaac      120

gctatcaaga acctgccccc accgctgggc ggcgctgcgg ggcacccagg ctctgcagtc      180

agcgccgcgc cgggaatcct gtacccgggc gggaataagt accagaccat tgacaactac      240

cagccgtacc cgtgcgcaga ggacgaggag tgcggcactg atgagtactg cgctagtccc      300

acccgcggag gggacgcagg cgtgcaaatc tgtctcgcct gcaggaagcg ccgaaaacgc      360

tgcatgcgtc acgctatgtg ctgccccggg aattactgca aaaatggaat atgtgtgtct      420

tctgatcaaa atcatttccg aggagaaatt gaggaaacca tcactgaaag ctttggtaat      480

gatcatagca ccttggatgg gtattccaga agaaccacct tgtcttcaaa aatgtatcac      540

accaaaggac aagaaggttc tgtttgtctc aggtcatcag actgtgcctc aggattgtgt      600

tgtgatagac acttctggtc caagatctgt aaacctgtcc tgaaagaagg tcaagtgtgt      660

accaagcata ggagaaaagg ctctcatgga ctagaaatat tccagcgttg ttactgtgga      720

gaaggtctgt cttgccggat acagaaagat caccatcaag ccagtaattc ttctaggctt      780

cacacttgtc agagacac                                                    798


<210>  2
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Met Ala Leu Gly Ala Ala Gly Ala Thr Arg Val Phe Val Ala Met 
1               5                   10                  15      


Val Ala Ala Ala Leu Gly Gly His Pro Leu Leu Gly Val Ser Ala Thr 
            20                  25                  30          


Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn Leu Pro Pro Pro 
        35                  40                  45              


Leu Gly Gly Ala Ala Gly His Pro Gly Ser Ala Val Ser Ala Ala Pro 
    50                  55                  60                  


Gly Ile Leu Tyr Pro Gly Gly Asn Lys Tyr Gln Thr Ile Asp Asn Tyr 
65                  70                  75                  80  


Gln Pro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly Thr Asp Glu Tyr 
                85                  90                  95      


Cys Ala Ser Pro Thr Arg Gly Gly Asp Ala Gly Val Gln Ile Cys Leu 
            100                 105                 110         


Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His Ala Met Cys Cys 
        115                 120                 125             


Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Val Ser Ser Asp Gln Asn 
    130                 135                 140                 


His Phe Arg Gly Glu Ile Glu Glu Thr Ile Thr Glu Ser Phe Gly Asn 
145                 150                 155                 160 


Asp His Ser Thr Leu Asp Gly Tyr Ser Arg Arg Thr Thr Leu Ser Ser 
                165                 170                 175     


Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser 
            180                 185                 190         


Ser Asp Cys Ala Ser Gly Leu Cys Cys Asp Arg His Phe Trp Ser Lys 
        195                 200                 205             


Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg 
    210                 215                 220                 


Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly 
225                 230                 235                 240 


Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn 
                245                 250                 255     


Ser Ser Arg Leu His Thr Cys Gln Arg His 
            260                 265     


<210>  3
<211>  816
<212>  DNA
<213>  Mus musculus

<400>  3
atgatggttg tgtgtgcagc ggcagctgtc cggttcttgg ccgtgtttac aatgatggct       60

ctctgcagcc tccctctgct aggagccagt gccaccttga actcagttct catcaattcc      120

aacgcgatca agaacctgcc cccaccgctg ggtggtgctg gggggcagcc gggctctgct      180

gtcagtgtgg cgccgggagt tctctatgag ggcgggaaca agtaccagac tcttgacaac      240

taccagccct acccttgcgc tgaagatgag gagtgcggct ctgacgagta ctgctccagc      300

cccagccgcg gggcagccgg cgtcggaggt gtacagatct gtctggcttg ccgaaagcgc      360

aggaagcgct gcatgaggca cgctatgtgc tgccccggga actactgcaa aaatggaata      420

tgcatgccct ctgaccacag ccattttcct cgaggggaga ttgaggaaag catcattgaa      480

aaccttggta atgaccacaa cgccgccgcg ggggatggat atcccagaag aaccacactg      540

acttcaaaaa tatatcacac caaaggacaa gaaggctccg tctgcctccg atcatcagac      600

tgtgccgcag ggctgtgttg tgcaagacac ttctggtcca agatctgtaa acctgtcctt      660

aaagaaggtc aggtgtgcac caagcacaaa cggaaaggct cccacgggct ggagatattc      720

cagcgctgtt actgcgggga aggcctggct tgcaggatac agaaagatca ccatcaagcc      780

agcaattctt ctaggctcca cacctgccag agacac                                816


<210>  4
<211>  272
<212>  PRT
<213>  Mus musculus

<400>  4

Met Met Val Val Cys Ala Ala Ala Ala Val Arg Phe Leu Ala Val Phe 
1               5                   10                  15      


Thr Met Met Ala Leu Cys Ser Leu Pro Leu Leu Gly Ala Ser Ala Thr 
            20                  25                  30          


Leu Asn Ser Val Leu Ile Asn Ser Asn Ala Ile Lys Asn Leu Pro Pro 
        35                  40                  45              


Pro Leu Gly Gly Ala Gly Gly Gln Pro Gly Ser Ala Val Ser Val Ala 
    50                  55                  60                  


Pro Gly Val Leu Tyr Glu Gly Gly Asn Lys Tyr Gln Thr Leu Asp Asn 
65                  70                  75                  80  


Tyr Gln Pro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly Ser Asp Glu 
                85                  90                  95      


Tyr Cys Ser Ser Pro Ser Arg Gly Ala Ala Gly Val Gly Gly Val Gln 
            100                 105                 110         


Ile Cys Leu Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His Ala 
        115                 120                 125             


Met Cys Cys Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Met Pro Ser 
    130                 135                 140                 


Asp His Ser His Phe Pro Arg Gly Glu Ile Glu Glu Ser Ile Ile Glu 
145                 150                 155                 160 


Asn Leu Gly Asn Asp His Asn Ala Ala Ala Gly Asp Gly Tyr Pro Arg 
                165                 170                 175     


Arg Thr Thr Leu Thr Ser Lys Ile Tyr His Thr Lys Gly Gln Glu Gly 
            180                 185                 190         


Ser Val Cys Leu Arg Ser Ser Asp Cys Ala Ala Gly Leu Cys Cys Ala 
        195                 200                 205             


Arg His Phe Trp Ser Lys Ile Cys Lys Pro Val Leu Lys Glu Gly Gln 
    210                 215                 220                 


Val Cys Thr Lys His Lys Arg Lys Gly Ser His Gly Leu Glu Ile Phe 
225                 230                 235                 240 


Gln Arg Cys Tyr Cys Gly Glu Gly Leu Ala Cys Arg Ile Gln Lys Asp 
                245                 250                 255     


His His Gln Ala Ser Asn Ser Ser Arg Leu His Thr Cys Gln Arg His 
            260                 265                 270         


<210>  5
<211>  810
<212>  DNA
<213>  Rattus norvegicus

<400>  5
atgacggttg tgcgtgcagt ggcagctgtc cggttcttgg tcgtgcttac aacgatggct       60

ctctgcagcc tccctccgct cggagtcagc gccactttga actcagttct catcaattcc      120

aacgcgatca agaacctgcc cccaccgctg ggtggtgctg gggggcagcc gggctctgct      180

gtcagcgtgg cgcccggagt cctctatgag ggcgggaaca agtaccagac tcttgacaac      240

taccagccct acccttgcgc ggaggatgag gagtgcggca ctgacgagta ctgctccagt      300

cccagccgcg gggcagccgg cgtgggaggt gtacaaatct gcctggcttg ccgaaagcgc      360

aggaaacgct gcatgaggca cgctatgtgc tgccccggga attactgcaa aaacggaata      420

tgcatgccct ctgaccacag ccatttacct cgaggggaaa tcgaggaagg catcattgaa      480

aaccttggca atgaccacgg tgccggggat ggatatccca gaagaaccac actgacttca      540

aaaatatatc acaccaaagg gcaagaaggc tctgtctgcc tccgatcatc agactgcgcc      600

acagggctgt gttgtgcaag acatttctgg tccaagatct gtaaacctgt ccttaaagaa      660

ggtcaggtat gcaccaagca cagaaggaaa ggctcccacg ggctggagat attccagcgc      720

tgttactgtg gggaaggtct ggcttgcagg atacagaaag atcaccatca aaccagcaat      780

tcttccaggc tccacacctg ccagagacac                                       810


<210>  6
<211>  270
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Thr Val Val Arg Ala Val Ala Ala Val Arg Phe Leu Val Val Leu 
1               5                   10                  15      


Thr Thr Met Ala Leu Cys Ser Leu Pro Pro Leu Gly Val Ser Ala Thr 
            20                  25                  30          


Leu Asn Ser Val Leu Ile Asn Ser Asn Ala Ile Lys Asn Leu Pro Pro 
        35                  40                  45              


Pro Leu Gly Gly Ala Gly Gly Gln Pro Gly Ser Ala Val Ser Val Ala 
    50                  55                  60                  


Pro Gly Val Leu Tyr Glu Gly Gly Asn Lys Tyr Gln Thr Leu Asp Asn 
65                  70                  75                  80  


Tyr Gln Pro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly Thr Asp Glu 
                85                  90                  95      


Tyr Cys Ser Ser Pro Ser Arg Gly Ala Ala Gly Val Gly Gly Val Gln 
            100                 105                 110         


Ile Cys Leu Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His Ala 
        115                 120                 125             


Met Cys Cys Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Met Pro Ser 
    130                 135                 140                 


Asp His Ser His Leu Pro Arg Gly Glu Ile Glu Glu Gly Ile Ile Glu 
145                 150                 155                 160 


Asn Leu Gly Asn Asp His Gly Ala Gly Asp Gly Tyr Pro Arg Arg Thr 
                165                 170                 175     


Thr Leu Thr Ser Lys Ile Tyr His Thr Lys Gly Gln Glu Gly Ser Val 
            180                 185                 190         


Cys Leu Arg Ser Ser Asp Cys Ala Thr Gly Leu Cys Cys Ala Arg His 
        195                 200                 205             


Phe Trp Ser Lys Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys 
    210                 215                 220                 


Thr Lys His Arg Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg 
225                 230                 235                 240 


Cys Tyr Cys Gly Glu Gly Leu Ala Cys Arg Ile Gln Lys Asp His His 
                245                 250                 255     


Gln Thr Ser Asn Ser Ser Arg Leu His Thr Cys Gln Arg His 
            260                 265                 270 


<210>  7
<211>  798
<212>  DNA
<213>  Macaca fascicularis

<400>  7
atgatggctc tgggcgcagc aggagctgcc cgggtcttgg tcgcgctggt agcggcggct       60

cttggcggcc accctctgct gggagtgagc gccaccttga actcggttct caattccaac      120

gcgatcaaga acctgccccc accgctgggc ggcgctgcgg ggcacccagg ctctgcagtc      180

agcgccgcgc caggaattct gtacccgggc gggaataagt accagaccat tgacaactac      240

cagccgtacc cttgcgcaga ggatgaggag tgcggcactg atgagtactg cgctagtccc      300

acccgcggag gggacgcggg cgtgcaaatc tgtctcgcct gcaggaagcg ccgaaaacgc      360

tgcatgcgtc acgctatgtg ctgccccggg aattactgca aaaatggaat atgtgtgtct      420

tctgatcaaa ataatttccg aggggaaatt gaggaaacca ttactgaaag ctttggtaat      480

gatcatagca ctttggatgg gtattccaga agaacaacat tgtcttcaaa aatgtatcac      540

agcaaaggac aagaaggttc tgtgtgtctc cggtcatcag actgtgccac aggactgtgt      600

tgtgctagac acttctggtc caagatctgt aaacctgtcc tcaaagaagg tcaagtgtgt      660

accaagcata gaagaaaagg ctctcatggg ctagaaatat tccagcgttg ttactgcgga      720

gaaggtctgt cttgccggat acagaaagat caccatcaag ccagtaattc ttctaggctt      780

cacacttgtc agagacac                                                    798


<210>  8
<211>  266
<212>  PRT
<213>  Macaca fascicularis

<400>  8

Met Met Ala Leu Gly Ala Ala Gly Ala Ala Arg Val Leu Val Ala Leu 
1               5                   10                  15      


Val Ala Ala Ala Leu Gly Gly His Pro Leu Leu Gly Val Ser Ala Thr 
            20                  25                  30          


Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn Leu Pro Pro Pro 
        35                  40                  45              


Leu Gly Gly Ala Ala Gly His Pro Gly Ser Ala Val Ser Ala Ala Pro 
    50                  55                  60                  


Gly Ile Leu Tyr Pro Gly Gly Asn Lys Tyr Gln Thr Ile Asp Asn Tyr 
65                  70                  75                  80  


Gln Pro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly Thr Asp Glu Tyr 
                85                  90                  95      


Cys Ala Ser Pro Thr Arg Gly Gly Asp Ala Gly Val Gln Ile Cys Leu 
            100                 105                 110         


Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His Ala Met Cys Cys 
        115                 120                 125             


Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Val Ser Ser Asp Gln Asn 
    130                 135                 140                 


Asn Phe Arg Gly Glu Ile Glu Glu Thr Ile Thr Glu Ser Phe Gly Asn 
145                 150                 155                 160 


Asp His Ser Thr Leu Asp Gly Tyr Ser Arg Arg Thr Thr Leu Ser Ser 
                165                 170                 175     


Lys Met Tyr His Ser Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser 
            180                 185                 190         


Ser Asp Cys Ala Thr Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys 
        195                 200                 205             


Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg 
    210                 215                 220                 


Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly 
225                 230                 235                 240 


Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn 
                245                 250                 255     


Ser Ser Arg Leu His Thr Cys Gln Arg His 
            260                 265     


<210>  9
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  9
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattaga gatgatttag gctggtttca gcagaaacca      120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtctacag cataatagtt acccgtgcag ttttggccag      300

gggaccaagc tggagttcaa a                                                321


<210>  10
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asp Asp 
            20                  25                  30          


Leu Gly Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Cys 
                85                  90                  95      


Ser Phe Gly Gln Gly Thr Lys Leu Glu Phe Lys 
            100                 105         


<210>  11
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  11
caggttcagc taatgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctg acaatggtca cacaaactat      180

gcacagaaac tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagatggg      300

gagctactaa attactacta ctactacggt atggacgtct ggggccaagg gaccacggtc      360

accgtctcct ca                                                          372


<210>  12
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Val Gln Leu Met Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Asp Asn Gly His Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Glu Leu Leu Asn Tyr Tyr Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  13
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  13
gatattgtga tgacccagac tccactctct ctgtccgtca ttcctggaca gccggcctcc       60

atctcctgca agtctagtca gagcctcctg catagtgatg gaaagaccta tttgtactgg      120

tacctgcaga ggccaggcca gcctccacag ctcctgatct atgaagtttc caaccggttc      180

tctggagtgc cacataggct cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgca tgcaaagtat acaggttccg      300

tggacgttcg gccaagggac caaggtggaa atcaaa                                336


<210>  14
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ile Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


His Arg Leu Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Ile Gln Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  15
cagtgtcagg tgcagctggt ggagtctggg ggaggcgtgg tccagcctgg gaggtccctg       60

agactctcct gtgcagcctc tggattcacc ttcagtagct atggcatgca ctgggtccgc      120

caggctccag gcaaggggct ggagtgggtg gcagttatat catatgatgg aagtgataaa      180

tactatgcag actccgtgaa gggccgattc accatctcca gagacaattc caagaacacg      240

ctgtatctgc aaatgaacag cctgagagct gaggacacgg ctgtgtatta ctgtgcgaga      300

gatcaatggg gtgggagccc agccggcccc tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  16
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Trp Gly Gly Ser Pro Ala Gly Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  17
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  17
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaactact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  18
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  19
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  19
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggaatg ggtggcagtt atatcatatg atggaagtga taaatactat      180

gcagactccg tgaagggccg attcaccttc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagaattg      300

ggtatagcag cttcctttga ctactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  20
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Gly Ile Ala Ala Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  21
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  21
gatattgtga tgacccagtc tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca agtctagtca gagcctcctg cacagtgatg gaaagaccta tttgtattgg      120

tatctgcaga agccaggcca gcctccacag ctcctgatct atgaagtttc caaccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtc tattactgca tgcaaagtat acaggttccg      300

tggacgttcg gccaagggac caaggtggaa atcaaa                                336


<210>  22
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Ile Gln Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  23
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  23
caggtgcaac tggtggagtc tggaggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggggtg ggtggcagtt atatcatatg atggaagtga taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagacctc      300

gtggatacag ctatgccctg gggccaaggg accacggtca ccgtctcctc a               351


<210>  24
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gly Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Val Asp Thr Ala Met Pro Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  25
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  25
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca agtctagtca gagcctcctg catagtgatg gaaagaccta tttgtattgg      120

tacctgcaga agccaggcca gcctccacag ctcctgatct atgaagtttc caaccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgca tgcaaagtaa acagcttcca      300

ttcactttcg gccctgggac caaagtggat atcaaa                                336


<210>  26
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  26

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Lys Gln Leu Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210>  27
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  27
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtga taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag ggctgaggac acggctgtgt attactgtgc gagagccggg      300

tactccctct actactacta cggtatggac gtctggggcc aagggaccac ggtcaccgtc      360

tcctca                                                                 366


<210>  28
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Tyr Ser Leu Tyr Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  29
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  29
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcttg gatagtgatg atggagacac ctatttggac      120

tggtacctgc agaagccagg gcagtctcca cagctcctga tctatacgct ttcctatcgg      180

gcctctggag tcccagacag gttcagtggc agtgggtcag gcactgattt cacactgaaa      240

atcagcaggg tggaggctga ggatgttgga gtttattact gcatgcaacg tatagagttt      300

ccattcactt tcggccctgg gaccaaagtg gatatcaaa                             339


<210>  30
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  30

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Asp Gly Asp Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Ile Glu Phe Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
            100                 105                 110         


Lys 
    


<210>  31
<211>  381
<212>  DNA
<213>  Homo sapiens

<400>  31
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtggct actactggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt ggggacatct attacagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc      240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagat      300

cgggcttacg gtgactacgg gggagactac tactacggta tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc a                                                381


<210>  32
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asp Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Ala Tyr Gly Asp Tyr Gly Gly Asp Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  33
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  33
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattaac aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaatctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gcagatattg caacatatta ctgtcaacaa tatgatgatt tcccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  34
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Ala Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asp Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  35
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  35

Cys Ala Gly Gly Thr Gly Cys Ala Ala Cys Thr Gly Cys Ala Gly Gly 
1               5                   10                  15      


Ala Gly Thr Cys Gly Gly Gly Cys Cys Cys Ala Gly Gly Ala Cys Thr 
            20                  25                  30          


Gly Gly Thr Gly Ala Ala Gly Cys Cys Thr Thr Cys Gly Gly Ala Gly 
        35                  40                  45              


Ala Cys Cys Cys Thr Gly Thr Cys Cys Cys Thr Cys Ala Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Cys Thr Gly Thr Cys Thr Cys Thr Gly Gly Thr Gly Gly 
65                  70                  75                  80  


Cys Thr Cys Cys Ala Thr Cys Ala Gly Thr Ala Gly Thr Thr Ala Cys 
                85                  90                  95      


Thr Ala Cys Thr Gly Gly Ala Gly Cys Thr Gly Gly Ala Thr Cys Cys 
            100                 105                 110         


Gly Gly Cys Ala Gly Cys Cys Cys Cys Cys Ala Gly Gly Gly Ala Ala 
        115                 120                 125             


Gly Gly Gly Ala Cys Thr Gly Gly Ala Ala Thr Gly Gly Ala Thr Thr 
    130                 135                 140                 


Gly Gly Gly Thr Ala Thr Ala Thr Cys Thr Ala Thr Thr Ala Cys Ala 
145                 150                 155                 160 


Gly Thr Gly Gly Gly Ala Ala Cys Ala Cys Cys Ala Ala Thr Thr Ala 
                165                 170                 175     


Cys Ala Ala Cys Cys Cys Cys Thr Cys Cys Cys Thr Cys Ala Ala Gly 
            180                 185                 190         


Ala Gly Thr Cys Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Ala Thr 
        195                 200                 205             


Cys Ala Gly Thr Ala Gly Ala Cys Ala Cys Gly Thr Cys Cys Ala Ala 
    210                 215                 220                 


Gly Ala Ala Cys Cys Ala Gly Thr Thr Cys Thr Cys Cys Cys Thr Gly 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Ala Gly Gly Thr Cys Thr Gly Thr Gly Ala 
                245                 250                 255     


Cys Cys Gly Cys Thr Gly Cys Gly Gly Ala Cys Ala Cys Gly Gly Cys 
            260                 265                 270         


Cys Gly Thr Ala Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Gly 
        275                 280                 285             


Ala Gly Gly Thr Ala Thr Ala Ala Cys Thr Gly Gly Ala Ala Cys Ala 
    290                 295                 300                 


Ala Cys Gly Ala Cys Cys Thr Cys Thr Thr Thr Gly Ala Cys Thr Ala 
305                 310                 315                 320 


Cys Thr Gly Gly Gly Gly Cys Cys Ala Gly Gly Gly Ala Ala Cys Cys 
                325                 330                 335     


Cys Thr Gly Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr Cys Cys Thr 
            340                 345                 350         


Cys Ala 
        


<210>  36
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asn Trp Asn Asn Asp Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  37
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  37
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaactgg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacaa tatgataatc tccctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  38
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  39
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  39
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtgtg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca gttccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagggggc      300

tatggttcgg ggagttatga ggactactac tacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210>  40
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  40

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Cys Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Gly Ser Gly Ser Tyr Glu Asp Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  41
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  41
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagt aaggatttaa attggtatca gcagaaacca      120

gggaaagccc ctaggctcct gatctacgat gcatccaatt tggaaacggg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatttta ctgtcaacag tatgatcatc tcccgatcgc cttcggccaa      300

gggacacgac tggagattaa a                                                321


<210>  42
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Lys Asp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Phe Tyr Cys Gln Gln Tyr Asp His Leu Pro Ile 
                85                  90                  95      


Ala Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  43
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  43
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc      120

actggccaag ggcttgagtg gatgggatgg atggacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggcag agtcaccatg accaggaaca cctccataag cacagccttc      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaacggac      300

tacttctact tcggtatgga cgtctggggc caagggacca cggtcaccgt ctcctca         357


<210>  44
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asp Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asp Tyr Phe Tyr Phe Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  45
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  45
gacatccagg tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagttcct gatctacgat gcatccaatt tggaagcagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatc tcccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  46
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  46

Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  47
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  47
caggtgcagt tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagaaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagggggg      300

ggagcagtgg ctgattacaa ctactactac ggtatggacg tctggggcca agggaccacg      360

gtcaccgtct cctca                                                       375


<210>  48
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ala Val Ala Asp Tyr Asn Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  49
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  49
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aaggatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgatgatc tcccgatcac cttcggccaa      300

gggacacgac tggagattaa a                                                321


<210>  50
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  50

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Lys Asp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asp Leu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  51
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  51
caggtgcagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cctctggatt caccttcacc agttatgata tcagctgggt gcgacaggcc      120

actggactag ggcttgagtg gatgggatgg atgaacccta gcagtggtta cacaggctat      180

gcacagaact tccagggcag agtcaccatg acctggaaca cctccataag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaacggac      300

tactactact acggtatgga cgtctggggc cgagggacca cggtcaccgt ctcctca         357


<210>  52
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Ser Trp Val Arg Gln Ala Thr Gly Leu Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Ser Ser Gly Tyr Thr Gly Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Trp Asn Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asp Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Arg Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  53
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  53
gacatccggt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcaggaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatt tcccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  54
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  54

Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Glu Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  55
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  55
caggtgctac tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagacc      120

ccagggaagg gactggagtg gattgggtat gtctattaca gtgggagcac cagctacaac      180

ccctccctca agagtcgagt caccatatca atgtacacgt ccaagaccga gttctccctg      240

aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag gtataactgg      300

aacaacgacc tctttgacta ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  56
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Val Leu Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Tyr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Met Tyr Thr Ser Lys Thr Glu Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asn Trp Asn Asn Asp Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  57
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  57
tcctatgtgt tgactcagcc accctcggtg tcagtggccc caggacagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgttg gatagtagta gtgatcatgt gatattcggc      300

ggagggacca agctgaccgt ccta                                             324


<210>  58
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  58

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Leu Asp Ser Ser Ser Asp His 
                85                  90                  95      


Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  59
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  59
tcctatgtgt tgactcagcc accctcggtg tcagtggccc caggacagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgttg gatagtagta gtgatcatgt gatattcggc      300

ggagggacca agctgaccgt ccta                                             324


<210>  60
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  60

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Gly Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Gly Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Phe Gly Glu Leu Glu Pro Arg Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  61
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  61
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggacagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtgaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtagta atgatcatgt ggttttcggc      300

ggagggacca agctgaccgt ccta                                             324


<210>  62
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  62

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Glu Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Asn Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  63
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  63
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtagtaatt actactgggg ctggatccgc      120

cagcccccgg ggaaggggct ggagtggatt gggactatct attatagtgg gagcacctac      180

tacaccccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgccgca gacacggctg tctattactg tgcgagagag      300

agggcgatag cagtggctgc tatagtcttc tttgactact ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210>  64
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Thr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Thr Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Arg Ala Ile Ala Val Ala Ala Ile Val Phe Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  65
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  65
tcctatgtgc tgactcagtc accctcggtg tcagtggccc caggacagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actactactg tcaggtgtgg gatagtagta gtgatcattg ggtgttcggc      300

ggagggacca agctgaccgt ccta                                             324


<210>  66
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  66

Gln Ser Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr 
1               5                   10                  15      


Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln 
            20                  25                  30          


Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg 
        35                  40                  45              


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    50                  55                  60                  


Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr 
65                  70                  75                  80  


Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His Trp Val Phe Gly Gly 
                85                  90                  95      


Gly Thr Lys Leu Thr Val Leu 
            100             


<210>  67
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  67
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc      120

actggacaag ggcttgagtg gatgggatgg atgaatctta acagtgataa cacaggctat      180

gcacagaagt tccagggcag agtcaccatg accaggaaca cctccataag cactgcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagtatagca      300

gctcgtcgcg actacaacta ctacggtatg gacgtctggg gccaagggac caaggtcacc      360

gtctcctca                                                              369


<210>  68
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  68

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Leu Asn Ser Asp Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ile Ala Ala Arg Arg Asp Tyr Asn Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Lys Val Thr Val Ser Ser 
        115                 120             


<210>  69
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  69
gaaattgtgt tgacgcagtc tccaggcacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta tcagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatccg gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcattc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcattcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  70
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  70

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Gly Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  71
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  71
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atattatatg atggaagtga taattactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagaaggg      300

atagcagtgg ctggggacta ctactactac ggtatggacg tctggggcca agggaccacg      360

gtcaccgtct cctca                                                       375


<210>  72
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  72

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Leu Tyr Asp Gly Ser Asp Asn Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ile Ala Val Ala Gly Asp Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  73
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  73
cagtcagtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcagattatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatgattaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acaacagcct gagtggttat      300

gtggtattcg gcggagggac caagctgacc gtccta                                336


<210>  74
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  74

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Asp 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Tyr Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser 
                85                  90                  95      


Leu Ser Gly Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  75
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  75
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgac ggcctcggac accgccatgt attactgtgc gagacaggga      300

gagagctttg actactgggg ccagggaacc ctggtcaccg tctcctca                   348


<210>  76
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  76

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Thr Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Glu Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  77
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  77
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaagaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctgactc caagtctggc acctcagcct ccctggccat cactggcctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtgtgata      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  78
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  78

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Arg Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Asp Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  79
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  79
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg tttctggata cagctttacc acctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggactg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagacaaggt      300

atagcgtttg actactgggg ccagggaacc ctggtcaccg tctcctca                   348


<210>  80
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  80

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Ile Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  81
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  81
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca agtctggtca gagcctcctg catagtgatg gaaagaccta tttgtattgg      120

tacctgcaga agccaggcca gcctccacag ttcctgatct atgaagtttc caaccggttc      180

tctagagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgagaatc      240

agccgggtgg aggctgagga tgttggaatt tattactgca tgcaaagtat acagcttccg      300

tggacgttcg gccaagggac ccaggtggaa atcaaa                                336


<210>  82
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  82

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Gly Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Phe Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Arg Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Ile Gln Leu Pro Trp Thr Phe Gly Gln Gly Thr Gln Val Glu Ile Lys 
            100                 105                 110         


<210>  83
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  83
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaaatga taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca atgccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagagcta      300

cgggtcctct ggggccaggg aaccctggtc accgtctcta gt                         342


<210>  84
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  84

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Asn Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Arg Val Leu Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  85
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  85
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca agtctggtca gagcctcctg cataatgatg gaaagaccta tttgtattgg      120

tacctgcaga agccaggcca gcctccacag ttcctgatct atgaagtttc caaccggttc      180

tctagagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggaatt tattactgca tgcaaagtat acagcttccg      300

tggacgttcg gccaagggac ccaggtggaa atcaaa                                336


<210>  86
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  86

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Gly Gln Ser Leu Leu His Asn 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Phe Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Arg Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Ile Gln Leu Pro Trp Thr Phe Gly Gln Gly Thr Gln Val Glu Ile Lys 
            100                 105                 110         


<210>  87
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  87
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaaatga taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca atgccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgttt attactgtgc gagagagcta      300

cgggtcctct ggggccaggg aaccctggtc accgtctcct ca                         342


<210>  88
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  88

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Asn Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Arg Val Leu Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  89
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  89
gatattgtga tgacccagac tccactctct ctgtccgtca cccctagaca gccggcctcc       60

atctcctgca agtctagtca gagcctcctg catagtgatg gaaagaccta tttgtattgg      120

tacctgcaga agccaggcca gcctccacag ttcctgatct atgaagtttc caaccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgca tgcaaagtat acagcttccg      300

tggacgttcg gccaagggac caaggtggaa atcaaa                                336


<210>  90
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  90

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Arg 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Phe Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Ile Gln Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  91
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  91
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaggtga tcaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag aactgaggac acggctgagt attactgtgc gagagagctc      300

cgggtcctct ggggccaggg aaccctggtc accgtctcct ca                         342


<210>  92
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  92

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Gly Asp Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Glu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Arg Val Leu Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  93
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  93
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggacagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtacact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat agtgaccggc cctcagagat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtagta gtgatcatgt ggtattcggc      300

ggagggacca ggctgaccgt ccta                                             324


<210>  94
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  94

Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr 
1               5                   10                  15      


Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp 
        35                  40                  45              


Asp Ser Asp Arg Pro Ser Glu Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    50                  55                  60                  


Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Arg Leu Thr Val Leu 
            100                 105         


<210>  95
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  95
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt cgctatgaca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaatt atattctatg atggcagcaa taaatactat      180

gcagaccccg tgaagggccg attcaccatc tccagagaca attcaaagaa cacactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gactctagca      300

gcagcttttg actactgggg ccagggaacc ctggtcaccg tctcctca                   348


<210>  96
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  96

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Phe Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Pro Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Ala Ala Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  97
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  97

Arg Ala Ser Gln Gly Ile Arg Asp Asp Leu Gly 
1               5                   10      


<210>  98
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  98

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  99
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  99

Leu Gln His Asn Ser Tyr Pro Cys Ser 
1               5                   


<210>  100
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  100

Ser Tyr Gly Ile Ser 
1               5   


<210>  101
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  101

Trp Ile Ser Ala Asp Asn Gly His Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  102
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  102

Asp Gly Glu Leu Leu Asn Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  103
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  103

Lys Ser Ser Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  104
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  104

Glu Val Ser Asn Arg Phe Ser 
1               5           


<210>  105
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Gln Ser Ile Gln Val Pro Trp Thr 
1               5                   


<210>  106
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  106

Ser Tyr Gly Met His 
1               5   


<210>  107
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  107

Val Ile Ser Tyr Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  108
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  108

Asp Gln Trp Gly Gly Ser Pro Ala Gly Pro 
1               5                   10  


<210>  109
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  109

Arg Ala Ser Gln Ser Val Ser Ser Asn Tyr Leu Ala 
1               5                   10          


<210>  110
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  110

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  111
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  111

Gln Gln Tyr Gly Ser Ser Pro Ile Thr 
1               5                   


<210>  112
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  112

Ser Tyr Gly Met His 
1               5   


<210>  113
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  113

Val Ile Ser Tyr Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  114
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  114

Glu Leu Gly Ile Ala Ala Ser Phe Asp Tyr 
1               5                   10  


<210>  115
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  115

Lys Ser Ser Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  116
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  116

Glu Val Ser Asn Arg Phe Ser 
1               5           


<210>  117
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Gln Ser Ile Gln Val Pro Trp Thr 
1               5                   


<210>  118
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  118

Ser Tyr Gly Met His 
1               5   


<210>  119
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  119

Val Ile Ser Tyr Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  120
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  120

Asp Leu Val Asp Thr Ala Met Pro 
1               5               


<210>  121
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  121

Lys Ser Ser Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  122
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  122

Glu Val Ser Asn Arg Phe Ser 
1               5           


<210>  123
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Gln Ser Lys Gln Leu Pro Phe Thr 
1               5                   


<210>  124
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  124

Ser Tyr Gly Met His 
1               5   


<210>  125
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  125

Val Ile Ser Tyr Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  126
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  126

Ala Gly Tyr Ser Leu Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10              


<210>  127
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  127

Arg Ser Ser Gln Ser Leu Leu Asp Ser Asp Asp Gly Asp Thr Tyr Leu 
1               5                   10                  15      


Asp 
    


<210>  128
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  128

Thr Leu Ser Tyr Arg Ala Ser 
1               5           


<210>  129
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Gln Arg Ile Glu Phe Pro Met Gln Arg Ile Glu Phe Pro 
1               5                   10                  


<210>  130
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  130

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  131
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  131

Asp Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  132
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  132

Asp Arg Ala Tyr Gly Asp Tyr Gly Gly Asp Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  133
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  133

Gln Ala Ser Gln Asp Ile Asn Asn Tyr Leu Asn 
1               5                   10      


<210>  134
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  134

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  135
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  135

Gln Gln Tyr Asp Asp Phe Pro Leu Thr 
1               5                   


<210>  136
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  136

Ser Tyr Tyr Trp Ser 
1               5   


<210>  137
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  137

Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  138
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  138

Tyr Asn Trp Asn Asn Asp Leu Phe Asp Tyr 
1               5                   10  


<210>  139
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  139

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  140
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  140

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  141
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  141

Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  142
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  142

Ser Tyr Gly Met His 
1               5   


<210>  143
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  143

Val Ile Trp Cys Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  144
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  144

Gly Gly Tyr Gly Ser Gly Ser Tyr Glu Asp Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  145
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  145

Gln Ala Ser Gln Asp Ile Ser Lys Asp Leu Asn 
1               5                   10      


<210>  146
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  146

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  147
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  147

Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  148
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  148

Ser Tyr Gly Met His 
1               5   


<210>  149
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  149

Trp Met Asp Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  150
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  150

Thr Asp Tyr Phe Tyr Phe Gly Met Asp Val 
1               5                   10  


<210>  151
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  151

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  152
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  152

Asp Ala Ser Asn Leu Glu Ala 
1               5           


<210>  153
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  153

Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  154
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  154

Ser Tyr Gly Met His 
1               5   


<210>  155
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  155

Val Ile Trp Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  156
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  156

Gly Gly Gly Ala Val Ala Asp Tyr Asn Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  157
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  157

Gln Ala Ser Gln Asp Ile Ser Lys Asp Leu Asn 
1               5                   10      


<210>  158
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  158

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  159
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  159

Gln Gln Tyr Asp Asp Leu Pro Ile Thr 
1               5                   


<210>  160
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  160

Ser Tyr Asp Ile Ser 
1               5   


<210>  161
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  161

Trp Met Asn Pro Ser Ser Gly Tyr Thr Gly Tyr Ala Gln Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  162
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  162

Thr Asp Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10  


<210>  163
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  163

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  164
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  164

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  165
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  165

Gln Gln Tyr Asp Asn Phe Pro Leu Thr 
1               5                   


<210>  166
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  166

Ser Tyr Tyr Trp Ser 
1               5   


<210>  167
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  167

Tyr Val Tyr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  168
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  168

Tyr Asn Trp Asn Asn Asp Leu Phe Asp Tyr 
1               5                   10  


<210>  169
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  169

Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 
1               5                   10      


<210>  170
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  170

Asp Asp Ser Asp Arg Pro Ser 
1               5           


<210>  171
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  171

Gln Val Leu Asp Ser Ser Ser Asp His Val Ile 
1               5                   10      


<210>  172
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  172

Asn Tyr Ala Met Ser 
1               5   


<210>  173
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  173

Ala Ile Ser Gly Gly Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  174
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  174

Glu Phe Gly Glu Leu Glu Pro Arg Phe Asp Tyr 
1               5                   10      


<210>  175
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  175

Gly Gly Asn Asn Ile Gly Ser Glu Ser Val His 
1               5                   10      


<210>  176
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  176

Asp Asp Ser Asp Arg Pro Ser 
1               5           


<210>  177
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  177

Gln Val Trp Asp Ser Ser Asn Asp His Val Val 
1               5                   10      


<210>  178
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  178

Ser Ser Asn Tyr Tyr Trp Gly 
1               5           


<210>  179
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  179

Thr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Thr Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  180
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  180

Glu Arg Ala Ile Ala Val Ala Ala Ile Val Phe Phe Asp Tyr 
1               5                   10                  


<210>  181
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  181

Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 
1               5                   10      


<210>  182
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  182

Asp Asp Ser Asp Arg Pro Ser 
1               5           


<210>  183
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  183

Gln Val Trp Asp Ser Ser Ser Asp His Trp Val 
1               5                   10      


<210>  184
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  184

Ser Tyr Asp Ile Asn 
1               5   


<210>  185
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  185

Trp Met Asn Leu Asn Ser Asp Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  186
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  186

Ile Ala Ala Arg Arg Asp Tyr Asn Tyr Tyr Gly Met Asp Val 
1               5                   10                  


<210>  187
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  187

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  188
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  188

Gly Ala Ser Gly Arg Ala Thr 
1               5           


<210>  189
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  189

Gln Gln Tyr Gly Ser Ser Phe Thr 
1               5               


<210>  190
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  190

Ser Tyr Gly Met His 
1               5   


<210>  191
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  191

Val Ile Leu Tyr Asp Gly Ser Asp Asn Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  192
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  192

Glu Gly Ile Ala Val Ala Gly Asp Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  193
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  193

Thr Gly Ser Ser Ser Asn Ile Gly Ala Asp Tyr Asp Val His 
1               5                   10                  


<210>  194
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  194

Asp Tyr Ser Asn Arg Pro Ser 
1               5           


<210>  195
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  195

Gln Ser Tyr Asp Asn Ser Leu Ser Gly Tyr Val Val 
1               5                   10          


<210>  196
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  196

Ser Tyr Trp Ile Gly 
1               5   


<210>  197
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  197

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  198
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  198

Gln Gly Glu Ser Phe Asp Tyr 
1               5           


<210>  199
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  199

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  200
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  200

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  201
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  201

Gln Ser Tyr Asp Ser Ser Leu Ser Val Ile 
1               5                   10  


<210>  202
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  202

Thr Tyr Trp Ile Gly 
1               5   


<210>  203
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  203

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  204
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  204

Gln Gly Ile Ala Phe Asp Tyr 
1               5           


<210>  205
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  205

Lys Ser Gly Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  206
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  206

Glu Val Ser Asn Arg Phe Ser 
1               5           


<210>  207
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Gln Ser Ile Gln Leu Pro Trp Thr 
1               5                   


<210>  208
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  208

Gly Tyr Gly Met His 
1               5   


<210>  209
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  209

Val Ile Ser Tyr Asp Gly Asn Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  210
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  210

Glu Leu Arg Val Leu 
1               5   


<210>  211
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  211

Lys Ser Gly Gln Ser Leu Leu His Asn Asp Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  212
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  212

Glu Val Ser Asn Arg Phe Ser 
1               5           


<210>  213
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Gln Ser Ile Gln Leu Pro Trp Thr 
1               5                   


<210>  214
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  214

Gly Tyr Gly Met His 
1               5   


<210>  215
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  215

Val Ile Ser Tyr Asp Gly Asn Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  216
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  216

Glu Leu Arg Val Leu 
1               5   


<210>  217
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  217

Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr Asp Met His 
1               5                   10              


<210>  218
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  218

Ile Phe Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp 
1               5                   10          


<210>  219
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  219

Ala Thr Leu Ala Ala Ala Phe Asp Tyr 
1               5                   


<210>  220
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  220

Ser Tyr Gly Met His 
1               5   


<210>  221
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  221

Val Ile Ser Tyr Asp Gly Gly Asp Gln Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  222
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  222

Glu Leu Arg Val Leu 
1               5   


<210>  223
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  223

Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 
1               5                   10      


<210>  224
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  224

Asp Asp Ser Asp Arg Pro Ser 
1               5           


<210>  225
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  225

Gln Val Trp Asp Ser Ser Ser Asp His Val Val 
1               5                   10      


<210>  226
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  226

Arg Tyr Asp Met His 
1               5   


<210>  227
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  227

Ile Ile Phe Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Pro Val Lys 
1               5                   10                  15      


Gly 
    


<210>  228
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  228

Leu Ala Ala Ala Phe Asp Tyr 
1               5           


<210>  229
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  229
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagag                                                    318


<210>  230
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  230

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  231
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  231
ggtcagccca aggccaaccc cactgtcact ctgttcccgc cctcctctga ggagctccaa       60

gccaacaagg ccacactagt gtgtctgatc agtgacttct acccgggagc tgtgacagtg      120

gcctggaagg cagatggcag ccccgtcaag gcgggagtgg agaccaccaa accctccaaa      180

cagagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  232
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  232

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  233
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  233
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  234
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  234

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  235
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  235
ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacaaaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  236
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  236

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  237
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  237
ggtcagccca aggctgcccc atcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgcctgatc agtgacttct acccgggagc tgtgaaagtg      120

gcctggaagg cagatggcag ccccgtcaac acgggagtgg agaccaccac accctccaaa      180

cagagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctgcag aatgtgca                                                    318


<210>  238
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  238

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Asn Thr Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ala 
            100                 105     


<210>  239
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  239
ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      180

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      240

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctgcag aatgctct                                                    318


<210>  240
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  240

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  241
<211>  978
<212>  DNA
<213>  Homo sapiens

<400>  241
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      960

tccctgtctc cgggtaaa                                                    978


<210>  242
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  242

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  243
<211>  981
<212>  DNA
<213>  Homo sapiens

<400>  243
gccagcacca aggggccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc atcatgccca gcacctgagt tcgagggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  244
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  244

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


