                         SEQUENCE LISTING

<110>  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
 
<120>  COMPOUNDS FOR DELIVERING A THERAPEUTIC OR IMAGING AGENT TO THE 
       BRAIN

<130>  BET11P2871

<150>  EP 10306215.4
<151>  2010-11-05

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  168
<212>  PRT
<213>  Neisseria meningitidis

<400>  1

Met Asn Thr Leu Gln Lys Gly Phe Thr Leu Ile Glu Leu Met Ile Val 
1               5                   10                  15      


Ile Ala Ile Val Gly Ile Leu Ala Ala Val Ala Leu Pro Ala Tyr Gln 
            20                  25                  30          


Asp Tyr Thr Ala Arg Ala Gln Val Ser Glu Ala Ile Leu Leu Ala Glu 
        35                  40                  45              


Gly Gln Lys Ser Ala Val Thr Glu Tyr Tyr Leu Asn His Gly Glu Trp 
    50                  55                  60                  


Pro Gly Asp Asn Ser Ser Ala Gly Val Ala Thr Ser Ala Asp Ile Lys 
65                  70                  75                  80  


Gly Lys Tyr Val Gln Ser Val Thr Val Ala Asn Gly Val Ile Thr Ala 
                85                  90                  95      


Gln Met Ala Ser Ser Asn Val Asn Asn Glu Ile Lys Ser Lys Lys Leu 
            100                 105                 110         


Ser Leu Trp Ala Lys Arg Gln Asn Gly Ser Val Lys Trp Phe Cys Gly 
        115                 120                 125             


Gln Pro Val Thr Arg Thr Thr Ala Thr Ala Thr Asp Val Ala Ala Ala 
    130                 135                 140                 


Asn Gly Lys Thr Asp Asp Lys Ile Asn Thr Lys His Leu Pro Ser Thr 
145                 150                 155                 160 


Cys Arg Asp Asp Ser Ser Ala Ser 
                165             


<210>  2
<211>  129
<212>  PRT
<213>  Neisseria meningitidis

<400>  2

Met Lys Asn Val Gln Lys Gly Phe Thr Leu Leu Glu Leu Met Ile Ala 
1               5                   10                  15      


Val Ala Ile Leu Gly Ile Leu Thr Leu Ile Thr Tyr Pro Ser Tyr Lys 
            20                  25                  30          


Thr Tyr Ile Arg Arg Val Arg Leu Ser Glu Val Arg Thr Thr Leu Leu 
        35                  40                  45              


His Asn Ala Gln Thr Met Glu Arg Tyr Tyr Arg Gln Lys Gly Thr Phe 
    50                  55                  60                  


Lys Thr Tyr Asp Lys Asn Lys Leu Lys Gln Asn Lys Tyr Phe Asn Val 
65                  70                  75                  80  


Thr Leu Ser Lys Val Ser Pro Asp His Phe Thr Leu Gln Ala Asp Pro 
                85                  90                  95      


Asn Pro Thr Thr Asn Asp Gly Glu Thr Cys Val Val Thr Leu Asn Asp 
            100                 105                 110         


Gly Gly Thr Ile Ala Ala Ser Gly Thr Asn Gln Ser Cys Pro Gly Phe 
        115                 120                 125             


Asp 
    


<210>  3
<211>  413
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(28)
<223>  N-terminus

<400>  3

Met Gly Gln Pro Gly Asn Gly Ser Ala Phe Leu Leu Ala Pro Asn Gly 
1               5                   10                  15      


Ser His Ala Pro Asp His Asp Val Thr Gln Glu Arg Asp Glu Val Trp 
            20                  25                  30          


Val Val Gly Met Gly Ile Val Met Ser Leu Ile Val Leu Ala Ile Val 
        35                  40                  45              


Phe Gly Asn Val Leu Val Ile Thr Ala Ile Ala Lys Phe Glu Arg Leu 
    50                  55                  60                  


Gln Thr Val Thr Asn Tyr Phe Ile Thr Ser Leu Ala Cys Ala Asp Leu 
65                  70                  75                  80  


Val Met Gly Leu Ala Val Val Pro Phe Gly Ala Ala His Ile Leu Met 
                85                  90                  95      


Lys Met Trp Thr Phe Gly Asn Phe Trp Cys Glu Phe Trp Thr Ser Ile 
            100                 105                 110         


Asp Val Leu Cys Val Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala 
        115                 120                 125             


Val Asp Arg Tyr Phe Ala Ile Thr Ser Pro Phe Lys Tyr Gln Ser Leu 
    130                 135                 140                 


Leu Thr Lys Asn Lys Ala Arg Val Ile Ile Leu Met Val Trp Ile Val 
145                 150                 155                 160 


Ser Gly Leu Thr Ser Phe Leu Pro Ile Gln Met His Trp Tyr Arg Ala 
                165                 170                 175     


Thr His Gln Glu Ala Ile Asn Cys Tyr Ala Asn Glu Thr Cys Cys Asp 
            180                 185                 190         


Phe Phe Thr Asn Gln Ala Tyr Ala Ile Ala Ser Ser Ile Val Ser Phe 
        195                 200                 205             


Tyr Val Pro Leu Val Ile Met Val Phe Val Tyr Ser Arg Val Phe Gln 
    210                 215                 220                 


Glu Ala Lys Arg Gln Leu Gln Lys Ile Asp Lys Ser Glu Gly Arg Phe 
225                 230                 235                 240 


His Val Gln Asn Leu Ser Gln Val Glu Gln Asp Gly Arg Thr Gly His 
                245                 250                 255     


Gly Leu Arg Arg Ser Ser Lys Phe Cys Leu Lys Glu His Lys Ala Leu 
            260                 265                 270         


Lys Thr Leu Gly Ile Ile Met Gly Thr Phe Thr Leu Cys Trp Leu Pro 
        275                 280                 285             


Phe Phe Ile Val Asn Ile Val His Val Ile Gln Asp Asn Leu Ile Arg 
    290                 295                 300                 


Lys Glu Val Tyr Ile Leu Leu Asn Trp Ile Gly Tyr Val Asn Ser Gly 
305                 310                 315                 320 


Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe Arg Ile Ala Phe 
                325                 330                 335     


Gln Glu Leu Leu Cys Leu Arg Arg Ser Ser Leu Lys Ala Tyr Gly Asn 
            340                 345                 350         


Gly Tyr Ser Ser Asn Gly Asn Thr Gly Glu Gln Ser Gly Tyr His Val 
        355                 360                 365             


Glu Gln Glu Lys Glu Asn Lys Leu Leu Cys Glu Asp Leu Pro Gly Thr 
    370                 375                 380                 


Glu Asp Phe Val Gly His Gln Gly Thr Val Pro Ser Asp Asn Ile Asp 
385                 390                 395                 400 


Ser Gln Gly Arg Asn Cys Ser Thr Asn Asp Ser Leu Leu 
                405                 410             


<210>  4
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA

<400>  4
aaagccuucu gcgcggagaa u                                                 21


<210>  5
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA

<400>  5
ggcuuguccu uccgcaaaga c                                                 21


<210>  6
<211>  23
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA

<400>  6
aagaaguacg agaagcugga guu                                               23


<210>  7
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  offtarget siRNA

<400>  7
gataaggtgc tgcgtggacc c                                                 21


<210>  8
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  8
gaattccggc gcgtccgcct gtcgg                                             25


<210>  9
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  9
ctgcagttag tcgaagccgg ggcagg                                            26


<210>  10
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  10
gaattcgaga aagcaaagat aaatgc                                            26


<210>  11
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  11
ctgcagctac ttaaataact tgcagtcc                                          28


<210>  12
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  12
attgagaccc tgtgcgtgat                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  13
ctgaaagacc ctggagtaga                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  14
ttcctacccc caatgtgtcc                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  15
tcttgctcag tgtccttgct                                                   20


<210>  16
<211>  35
<212>  PRT
<213>  Neisseria meningitidis

<400>  16

Cys Gly Gln Pro Val Thr Arg Thr Thr Ala Thr Ala Thr Asp Val Ala 
1               5                   10                  15      


Ala Ala Asn Gly Lys Thr Asp Asp Lys Ile Asn Thr Lys His Leu Pro 
            20                  25                  30          


Ser Thr Cys 
        35  


