                         SEQUENCE LISTING



<110>  Ben Gurion University of the Negev Research and Development

        Authority

       Monsonego, Alon

 

<120>  T-CELL THERAPY TO NEURODEGENERATIVE DISEASES



<130>  52447



<150>  US 61/414,453

<151>  2010-11-17



<160>  130   



<170>  PatentIn version 3.5



<210>  1

<211>  1240

<212>  DNA

<213>  Homo sapiens



<400>  1

cacattgttc tgatcatctg aagatcagct attagaagag aaagatcagt taagtccttt       60



ggacctgatc agcttgatac aagaactact gatttcaact tctttggctt aattctctcg      120



gaaacgatga aatatacaag ttatatcttg gcttttcagc tctgcatcgt tttgggttct      180



cttggctgtt actgccagga cccatatgta aaagaagcag aaaaccttaa gaaatatttt      240



aatgcaggtc attcagatgt agcggataat ggaactcttt tcttaggcat tttgaagaat      300



tggaaagagg agagtgacag aaaaataatg cagagccaaa ttgtctcctt ttacttcaaa      360



ctttttaaaa actttaaaga tgaccagagc atccaaaaga gtgtggagac catcaaggaa      420



gacatgaatg tcaagttttt caatagcaac aaaaagaaac gagatgactt cgaaaagctg      480



actaattatt cggtaactga cttgaatgtc caacgcaaag caatacatga actcatccaa      540



gtgatggctg aactgtcgcc agcagctaaa acagggaagc gaaaaaggag tcagatgctg      600



tttcgaggtc gaagagcatc ccagtaatgg ttgtcctgcc tgcaatattt gaattttaaa      660



tctaaatcta tttattaata tttaacatta tttatatggg gaatatattt ttagactcat      720



caatcaaata agtatttata atagcaactt ttgtgtaatg aaaatgaata tctattaata      780



tatgtattat ttataattcc tatatcctgt gactgtctca cttaatcctt tgttttctga      840



ctaattaggc aaggctatgt gattacaagg ctttatctca ggggccaact aggcagccaa      900



cctaagcaag atcccatggg ttgtgtgttt atttcacttg atgatacaat gaacacttat      960



aagtgaagtg atactatcca gttactgccg gtttgaaaat atgcctgcaa tctgagccag     1020



tgctttaatg gcatgtcaga cagaacttga atgtgtcagg tgaccctgat gaaaacatag     1080



catctcagga gatttcatgc ctggtgcttc caaatattgt tgacaactgt gactgtaccc     1140



aaatggaaag taactcattt gttaaaatta tcaatatcta atatatatga ataaagtgta     1200



agttcacaac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           1240





<210>  2

<211>  166

<212>  PRT

<213>  Homo sapiens



<400>  2



Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 

1               5                   10                  15      





Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 

            20                  25                  30          





Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 

        35                  40                  45              





Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 

    50                  55                  60                  





Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 

65                  70                  75                  80  





Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 

                85                  90                  95      





Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 

            100                 105                 110         





Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 

        115                 120                 125             





Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 

    130                 135                 140                 





Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 

145                 150                 155                 160 





Gly Arg Arg Ala Ser Gln 

                165     





<210>  3

<211>  921

<212>  DNA

<213>  Homo sapiens



<400>  3

ttctatgcaa agcaaaaagc cagcagcagc cccaagctga taagattaat ctaaagagca       60



aattatggtg taatttccta tgctgaaact ttgtagttaa ttttttaaaa aggtttcatt      120



ttcctattgg tctgatttca caggaacatt ttacctgttt gtgaggcatt ttttctcctg      180



gaagagaggt gctgattggc cccaagtgac tgacaatctg gtgtaacgaa aatttccaat      240



gtaaactcat tttccctcgg tttcagcaat tttaaatcta tatatagaga tatctttgtc      300



agcattgcat cgttagcttc tcctgataaa ctaattgcct cacattgtca ctgcaaatcg      360



acacctatta atgggtctca cctcccaact gcttccccct ctgttcttcc tgctagcatg      420



tgccggcaac tttgtccacg gacacaagtg cgatatcacc ttacaggaga tcatcaaaac      480



tttgaacagc ctcacagagc agaagactct gtgcaccgag ttgaccgtaa cagacatctt      540



tgctgcctcc aagaacacaa ctgagaagga aaccttctgc agggctgcga ctgtgctccg      600



gcagttctac agccaccatg agaaggacac tcgctgcctg ggtgcgactg cacagcagtt      660



ccacaggcac aagcagctga tccgattcct gaaacggctc gacaggaacc tctggggcct      720



ggcgggcttg aattcctgtc ctgtgaagga agccaaccag agtacgttgg aaaacttctt      780



ggaaaggcta aagacgatca tgagagagaa atattcaaag tgttcgagct gaatatttta      840



atttatgagt ttttgatagc tttatttttt aagtatttat atatttataa ctcatcataa      900



aataaagtat atatagaatc t                                                921





<210>  4

<211>  153

<212>  PRT

<213>  Homo sapiens



<400>  4



Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 

1               5                   10                  15      





Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 

            20                  25                  30          





Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 

        35                  40                  45              





Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 

    50                  55                  60                  





Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 

65                  70                  75                  80  





Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 

                85                  90                  95      





Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 

            100                 105                 110         





Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 

        115                 120                 125             





Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 

    130                 135                 140                 





Arg Glu Lys Tyr Ser Lys Cys Ser Ser 

145                 150             





<210>  5

<211>  873

<212>  DNA

<213>  Homo sapiens



<400>  5

ttctatgcaa agcaaaaagc cagcagcagc cccaagctga taagattaat ctaaagagca       60



aattatggtg taatttccta tgctgaaact ttgtagttaa ttttttaaaa aggtttcatt      120



ttcctattgg tctgatttca caggaacatt ttacctgttt gtgaggcatt ttttctcctg      180



gaagagaggt gctgattggc cccaagtgac tgacaatctg gtgtaacgaa aatttccaat      240



gtaaactcat tttccctcgg tttcagcaat tttaaatcta tatatagaga tatctttgtc      300



agcattgcat cgttagcttc tcctgataaa ctaattgcct cacattgtca ctgcaaatcg      360



acacctatta atgggtctca cctcccaact gcttccccct ctgttcttcc tgctagcatg      420



tgccggcaac tttgtccacg gacacaagtg cgatatcacc ttacaggaga tcatcaaaac      480



tttgaacagc ctcacagagc agaagaacac aactgagaag gaaaccttct gcagggctgc      540



gactgtgctc cggcagttct acagccacca tgagaaggac actcgctgcc tgggtgcgac      600



tgcacagcag ttccacaggc acaagcagct gatccgattc ctgaaacggc tcgacaggaa      660



cctctggggc ctggcgggct tgaattcctg tcctgtgaag gaagccaacc agagtacgtt      720



ggaaaacttc ttggaaaggc taaagacgat catgagagag aaatattcaa agtgttcgag      780



ctgaatattt taatttatga gtttttgata gctttatttt ttaagtattt atatatttat      840



aactcatcat aaaataaagt atatatagaa tct                                   873





<210>  6

<211>  137

<212>  PRT

<213>  Homo sapiens



<400>  6



Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 

1               5                   10                  15      





Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 

            20                  25                  30          





Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Asn Thr Thr 

        35                  40                  45              





Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 

    50                  55                  60                  





Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 

65                  70                  75                  80  





Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 

                85                  90                  95      





Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 

            100                 105                 110         





Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 

        115                 120                 125             





Arg Glu Lys Tyr Ser Lys Cys Ser Ser 

    130                 135         





<210>  7

<211>  1629

<212>  DNA

<213>  Homo sapiens



<400>  7

acacatcagg ggcttgctct tgcaaaacca aaccacaaga cagacttgca aaagaaggca       60



tgcacagctc agcactgctc tgttgcctgg tcctcctgac tggggtgagg gccagcccag      120



gccagggcac ccagtctgag aacagctgca cccacttccc aggcaacctg cctaacatgc      180



ttcgagatct ccgagatgcc ttcagcagag tgaagacttt ctttcaaatg aaggatcagc      240



tggacaactt gttgttaaag gagtccttgc tggaggactt taagggttac ctgggttgcc      300



aagccttgtc tgagatgatc cagttttacc tggaggaggt gatgccccaa gctgagaacc      360



aagacccaga catcaaggcg catgtgaact ccctggggga gaacctgaag accctcaggc      420



tgaggctacg gcgctgtcat cgatttcttc cctgtgaaaa caagagcaag gccgtggagc      480



aggtgaagaa tgcctttaat aagctccaag agaaaggcat ctacaaagcc atgagtgagt      540



ttgacatctt catcaactac atagaagcct acatgacaat gaagatacga aactgagaca      600



tcagggtggc gactctatag actctaggac ataaattaga ggtctccaaa atcggatctg      660



gggctctggg atagctgacc cagccccttg agaaacctta ttgtacctct cttatagaat      720



atttattacc tctgatacct caacccccat ttctatttat ttactgagct tctctgtgaa      780



cgatttagaa agaagcccaa tattataatt tttttcaata tttattattt tcacctgttt      840



ttaagctgtt tccatagggt gacacactat ggtatttgag tgttttaaga taaattataa      900



gttacataag ggaggaaaaa aaatgttctt tggggagcca acagaagctt ccattccaag      960



cctgaccacg ctttctagct gttgagctgt tttccctgac ctccctctaa tttatcttgt     1020



ctctgggctt ggggcttcct aactgctaca aatactctta ggaagagaaa ccagggagcc     1080



cctttgatga ttaattcacc ttccagtgtc tcggagggat tcccctaacc tcattcccca     1140



accacttcat tcttgaaagc tgtggccagc ttgttattta taacaaccta aatttggttc     1200



taggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggct gaggcgggtg     1260



gatcacttga ggtcaggagt tcctaaccag cctggtcaac atggtgaaac cccgtctcta     1320



ctaaaaatac aaaaattagc cgggcatggt ggcgcgcacc tgtaatccca gctacttggg     1380



aggctgaggc aagagaattg cttgaaccca ggagatggaa gttgcagtga gctgatatca     1440



tgcccctgta ctccagcctg ggtgacagag caagactctg tctcaaaaaa taaaaataaa     1500



aataaatttg gttctaatag aactcagttt taactagaat ttattcaatt cctctgggaa     1560



tgttacattg tttgtctgtc ttcatagcag attttaattt tgaataaata aatgtatctt     1620



attcacatc                                                             1629





<210>  8

<211>  178

<212>  PRT

<213>  Homo sapiens



<400>  8



Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 

1               5                   10                  15      





Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 

            20                  25                  30          





Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 

        35                  40                  45              





Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 

    50                  55                  60                  





Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 

65                  70                  75                  80  





Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 

                85                  90                  95      





Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 

            100                 105                 110         





Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 

        115                 120                 125             





Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 

    130                 135                 140                 





Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 

145                 150                 155                 160 





Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 

                165                 170                 175     





Arg Asn 

        





<210>  9

<211>  822

<212>  DNA

<213>  Homo sapiens



<400>  9

agttccctat cactctcttt aatcactact cacagtaacc tcaactcctg ccacaatgta       60



caggatgcaa ctcctgtctt gcattgcact aagtcttgca cttgtcacaa acagtgcacc      120



tacttcaagt tctacaaaga aaacacagct acaactggag catttactgc tggatttaca      180



gatgattttg aatggaatta ataattacaa gaatcccaaa ctcaccagga tgctcacatt      240



taagttttac atgcccaaga aggccacaga actgaaacat cttcagtgtc tagaagaaga      300



actcaaacct ctggaggaag tgctaaattt agctcaaagc aaaaactttc acttaagacc      360



cagggactta atcagcaata tcaacgtaat agttctggaa ctaaagggat ctgaaacaac      420



attcatgtgt gaatatgctg atgagacagc aaccattgta gaatttctga acagatggat      480



taccttttgt caaagcatca tctcaacact gacttgataa ttaagtgctt cccacttaaa      540



acatatcagg ccttctattt atttaaatat ttaaatttta tatttattgt tgaatgtatg      600



gtttgctacc tattgtaact attattctta atcttaaaac tataaatatg gatcttttat      660



gattcttttt gtaagcccta ggggctctaa aatggtttca cttatttatc ccaaaatatt      720



tattattatg ttgaatgtta aatatagtat ctatgtagat tggttagtaa aactatttaa      780



taaatttgat aaatataaaa aaaaaaaaaa aaaaaaaaaa aa                         822





<210>  10

<211>  153

<212>  PRT

<213>  Homo sapiens



<400>  10



Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 

1               5                   10                  15      





Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 

            20                  25                  30          





Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 

        35                  40                  45              





Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 

    50                  55                  60                  





Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 

65                  70                  75                  80  





Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 

                85                  90                  95      





Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 

            100                 105                 110         





Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 

        115                 120                 125             





Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 

    130                 135                 140                 





Cys Gln Ser Ile Ile Ser Thr Leu Thr 

145                 150             





<210>  11

<211>  390

<212>  PRT

<213>  Homo sapiens



<400>  11



Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 

1               5                   10                  15      





Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 

            20                  25                  30          





Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 

        35                  40                  45              





Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 

    50                  55                  60                  





Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 

65                  70                  75                  80  





Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 

                85                  90                  95      





Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 

            100                 105                 110         





Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 

        115                 120                 125             





His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 

    130                 135                 140                 





Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 

145                 150                 155                 160 





Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 

                165                 170                 175     





Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 

            180                 185                 190         





Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 

        195                 200                 205             





Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 

    210                 215                 220                 





Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 

225                 230                 235                 240 





Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 

                245                 250                 255     





Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 

            260                 265                 270         





Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 

        275                 280                 285             





Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 

    290                 295                 300                 





Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 

305                 310                 315                 320 





Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 

                325                 330                 335     





Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 

            340                 345                 350         





Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 

        355                 360                 365             





Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 

    370                 375                 380                 





Arg Ser Cys Lys Cys Ser 

385                 390 





<210>  12

<211>  3935

<212>  DNA

<213>  Homo sapiens



<400>  12

tacaacacag gctccagtat ataaatcagg caaattcccc atttgagcat gaacctctga       60



aaactgccgg catctgaggt ttcctccaag gccctctgaa gtgcagccca taatgaaggt      120



cttggcggca ggagttgtgc ccctgctgtt ggttctgcac tggaaacatg gggcggggag      180



ccccctcccc atcacccctg tcaacgccac ctgtgccata cgccacccat gtcacaacaa      240



cctcatgaac cagatcagga gccaactggc acagctcaat ggcagtgcca atgccctctt      300



tattctctat tacacagccc agggggagcc gttccccaac aacctggaca agctatgtgg      360



ccccaacgtg acggacttcc cgcccttcca cgccaacggc acggagaagg ccaagctggt      420



ggagctgtac cgcatagtcg tgtaccttgg cacctccctg ggcaacatca cccgggacca      480



gaagatcctc aaccccagtg ccctcagcct ccacagcaag ctcaacgcca ccgccgacat      540



cctgcgaggc ctccttagca acgtgctgtg ccgcctgtgc agcaagtacc acgtgggcca      600



tgtggacgtg acctacggcc ctgacacctc gggtaaggat gtcttccaga agaagaagct      660



gggctgtcaa ctcctgggga agtataagca gatcatcgcc gtgttggccc aggccttcta      720



gcaggaggtc ttgaagtgtg ctgtgaaccg agggatctca ggagttgggt ccagatgtgg      780



gggcctgtcc aagggtggct ggggcccagg gcatcgctaa acccaaatgg gggctgctgg      840



cagaccccga gggtgcctgg ccagtccact ccactctggg ctgggctgtg atgaagctga      900



gcagagtgga aacttccata gggagggagc tagaagaagg tgccccttcc tctgggagat      960



tgtggactgg ggagcgtggg ctggacttct gcctctactt gtccctttgg ccccttgctc     1020



actttgtgca gtgaacaaac tacacaagtc atctacaaga gccctgacca cagggtgaga     1080



cagcagggcc caggggagtg gaccagcccc cagcaaatta tcaccatctg tgcctttgct     1140



gccccttagg ttgggactta ggtgggccag aggggctagg atcccaaagg actccttgtc     1200



ccctagaagt ttgatgagtg gaagatagag aggggcctct gggatggaag gctgtcttct     1260



tttgaggatg atcagagaac ttgggcatag gaacaatctg gcagaagttt ccagaaggag     1320



gtcacttggc attcaggctc ttggggaggc agagaagcca ccttcaggcc tgggaaggaa     1380



gacactggga ggaggagagg cctggaaagc tttggtaggt tcttcgttct cttccccgtg     1440



atcttccctg cagcctggga tggccagggt ctgatggctg gacctgcagc aggggtttgt     1500



ggaggtgggt agggcagggg caggttgcta agtcaggtgc agaggttctg agggacccag     1560



gctcttcctc tgggtaaagg tctgtaagaa ggggctgggg tagctcagag tagcagctca     1620



catctgaggc cctgggaggc cttgtgaggt cacacagagg tacttgaggg ggactggagg     1680



ccgtctctgg tccccagggc aagggaacag cagaacttag ggtcagggtc tcagggaacc     1740



ctgagctcca agcgtgctgt gcgtctgacc tggcatgatt tctatttatt atgatatcct     1800



atttatatta acttattggt gctttcagtg gccaagttaa ttcccctttc cctggtccct     1860



actcaacaaa atatgatgat ggctcccgac acaagcgcca gggccagggc ttagcagggc     1920



ctggtctgga agtcgacaat gttacaagtg gaataagcct tacgggtgaa gctcagagaa     1980



gggtcggatc tgagagaatg gggaggcctg agtgggagtg gggggccttg ctccaccccc     2040



ccccatcccc tactgtgact tgctttaggg tgtcagggtc caggctgcag gggctgggcc     2100



aatttgtgga gaggccgggt gcctttctgt cttgattcca gggggctggt tcacactgtt     2160



cttgggcgcc ccagcattgt gttgtgaggc gcactgttcc tggcagatat tgtgccccct     2220



ggagcagtgg gcaagacagt ccttgtggcc caccctgtcc ttgtttctgt gtccccatgc     2280



tgcctctgaa atagcgccct ggaacaaccc tgcccctgca cccagcatgc tccgacacag     2340



cagggaagct cctcctgtgg cccggacacc catagacggt gcggggggcc tggctgggcc     2400



agaccccagg aaggtggggt agactggggg gatcagctgc ccattgctcc caagaggagg     2460



agagggaggc tgcagatgcc tgggactcag accaggaagc tgtgggccct cctgctccac     2520



ccccatccca ctcccaccca tgtctgggct cccaggcagg gaacccgatc tcttcctttg     2580



tgctggggcc aggcgagtgg agaaacgccc tccagtctga gagcagggga gggaaggagg     2640



cagcagagtt ggggcagctg ctcagagcag tgttctggct tcttctcaaa ccctgagcgg     2700



gctgccggcc tccaagttcc tccgacaaga tgatggtact aattatggta cttttcactc     2760



actttgcacc tttccctgtc gctctctaag cactttacct ggatggcgcg tgggcagtgt     2820



gcaggcaggt cctgaggcct ggggttgggg tggagggtgc ggcccggagt tgtccatctg     2880



tccatcccaa cagcaagacg aggatgtggc tgttgagatg tgggccacac tcacccttgt     2940



ccaggatgca gggactgcct tctccttcct gcttcatccg gcttagcttg gggctggctg     3000



cattccccca ggatgggctt cgagaaagac aaacttgtct ggaaaccaga gttgctgatt     3060



ccacccgggg ggcccggctg actcgcccat cacctcatct ccctgtggac ttgggagctc     3120



tgtgccaggc ccaccttgcg gccctggctc tgagtcgctc tcccacccag cctggacttg     3180



gccccatggg acccatcctc agtgctccct ccagatcccg tccggcagct tggcgtccac     3240



cctgcacagc atcactgaat cacagagcct ttgcgtgaaa cagctctgcc aggccgggag     3300



ctgggtttct cttccctttt tatctgctgg tgtggaccac acctgggcct ggccggagga     3360



agagagagtt taccaagaga gatgtctccg ggcccttatt tattatttaa acattttttt     3420



aaaaagcact gctagtttac ttgtctctcc tccccatcgt ccccatcgtc ctccttgtcc     3480



ctgacttggg gcacttccac cctgacccag ccagtccagc tctgccttgc cggctctcca     3540



gagtagacat agtgtgtggg gttggagctc tggcacccgg ggaggtagca tttccctgca     3600



gatggtacag atgttcctgc cttagagtca tctctagttc cccacctcaa tcccggcatc     3660



cagccttcag tcccgcccac gtgctagctc cgtgggccca ccgtgcggcc ttagaggttt     3720



ccctccttcc tttccactga aaagcacatg gccttgggtg acaaattcct ctttgatgaa     3780



tgtaccctgt ggggatgttt catactgaca gattattttt atttattcaa tgtcatattt     3840



aaaatattta ttttttatac caaatgaata cttttttttt taagaaaaaa aagagaaatg     3900



aataaagaat ctactcttga aaaaaaaaaa aaaaa                                3935





<210>  13

<211>  202

<212>  PRT

<213>  Homo sapiens



<400>  13



Met Lys Val Leu Ala Ala Gly Val Val Pro Leu Leu Leu Val Leu His 

1               5                   10                  15      





Trp Lys His Gly Ala Gly Ser Pro Leu Pro Ile Thr Pro Val Asn Ala 

            20                  25                  30          





Thr Cys Ala Ile Arg His Pro Cys His Asn Asn Leu Met Asn Gln Ile 

        35                  40                  45              





Arg Ser Gln Leu Ala Gln Leu Asn Gly Ser Ala Asn Ala Leu Phe Ile 

    50                  55                  60                  





Leu Tyr Tyr Thr Ala Gln Gly Glu Pro Phe Pro Asn Asn Leu Asp Lys 

65                  70                  75                  80  





Leu Cys Gly Pro Asn Val Thr Asp Phe Pro Pro Phe His Ala Asn Gly 

                85                  90                  95      





Thr Glu Lys Ala Lys Leu Val Glu Leu Tyr Arg Ile Val Val Tyr Leu 

            100                 105                 110         





Gly Thr Ser Leu Gly Asn Ile Thr Arg Asp Gln Lys Ile Leu Asn Pro 

        115                 120                 125             





Ser Ala Leu Ser Leu His Ser Lys Leu Asn Ala Thr Ala Asp Ile Leu 

    130                 135                 140                 





Arg Gly Leu Leu Ser Asn Val Leu Cys Arg Leu Cys Ser Lys Tyr His 

145                 150                 155                 160 





Val Gly His Val Asp Val Thr Tyr Gly Pro Asp Thr Ser Gly Lys Asp 

                165                 170                 175     





Val Phe Gln Lys Lys Lys Leu Gly Cys Gln Leu Leu Gly Lys Tyr Lys 

            180                 185                 190         





Gln Ile Ile Ala Val Leu Ala Gln Ala Phe 

        195                 200         





<210>  14

<211>  781

<212>  DNA

<213>  Homo sapiens



<400>  14

acacagagag aaaggctaaa gttctctgga ggatgtggct gcagagcctg ctgctcttgg       60



gcactgtggc ctgcagcatc tctgcacccg cccgctcgcc cagccccagc acgcagccct      120



gggagcatgt gaatgccatc caggaggccc ggcgtctcct gaacctgagt agagacactg      180



ctgctgagat gaatgaaaca gtagaagtca tctcagaaat gtttgacctc caggagccga      240



cctgcctaca gacccgcctg gagctgtaca agcagggcct gcggggcagc ctcaccaagc      300



tcaagggccc cttgaccatg atggccagcc actacaagca gcactgccct ccaaccccgg      360



aaacttcctg tgcaacccag attatcacct ttgaaagttt caaagagaac ctgaaggact      420



ttctgcttgt catccccttt gactgctggg agccagtcca ggagtgagac cggccagatg      480



aggctggcca agccggggag ctgctctctc atgaaacaag agctagaaac tcaggatggt      540



catcttggag ggaccaaggg gtgggccaca gccatggtgg gagtggcctg gacctgccct      600



gggccacact gaccctgata caggcatggc agaagaatgg gaatatttta tactgacaga      660



aatcagtaat atttatatat ttatattttt aaaatattta tttatttatt tatttaagtt      720



catattccat atttattcaa gatgttttac cgtaataatt attattaaaa atatgcttct      780



a                                                                      781





<210>  15

<211>  144

<212>  PRT

<213>  Homo sapiens



<400>  15



Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 

1               5                   10                  15      





Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 

            20                  25                  30          





Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 

        35                  40                  45              





Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 

    50                  55                  60                  





Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 

65                  70                  75                  80  





Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 

                85                  90                  95      





Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 

            100                 105                 110         





Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 

        115                 120                 125             





Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 

    130                 135                 140                 





<210>  16

<211>  4755

<212>  DNA

<213>  Homo sapiens



<400>  16

cacacacaca cacacacaca gagagaacat ctctagtaaa aagaaaagtt gagctttctt       60



agctagatgt gtgtattagc cagaaaaagc caaggagtga agggttttag agaactggag      120



gagataaagt ggagtctgca tatgggaggc atttgaaatg gacttaaatg tctttttaat      180



gctgactttt tcagttttct ccttaccaga cacattgttt tcatgacatt agccccaggc      240



atagacacat cattaaaatg aacatgtcaa aaaatgattt ctgtttagaa ataagcaaaa      300



cattttcagt tgtgaccacc caggtgtaga ataaagaaca gtggaattgg gagccctgag      360



ttctaacata aactttcttc atgacataag gcaagtcttc tatggccttt ggtttcctta      420



cctgtaaaac aggatggctc aatgaaatta tctttcttct ttgctataat agagtatctc      480



tgtgggaaga ggaaaaaaaa agtcaattta aaggctcctt atagttcccc aactgctgtt      540



ttattgtgct attcatgcct agacatcaca tagctagaaa ggcccatcag acccctcagg      600



ccactgctgt tcctgtcaca cattcctgca aaggaccatg ttgctaactt gaaaaaaatt      660



actattaatt acacttgcag ttgttgctta gtaacattta tgattttgtg tttctcgtga      720



cagcatgagc agagatcatt aaaaattaaa cttacaaagc tgctaaagtg ggaagaagga      780



gaacttgaag ccacaatttt tgcacttgct tagaagccat ctaatctcag gttatatgct      840



agatcttggg ggcaaacact gcatgtctct ggtttatatt aaaccacata cagcacacta      900



ctgacactga tttgtgtctg gtgcagctgg agtttatcac caagacataa aaaaaccttg      960



accctgcaga atggcctgga attacaatca gatgggccac atggcatccc ggtgaaagaa     1020



agccctaacc agttttctgt cttgtttctg ctttctccct acagttccac caggtgagaa     1080



gagtgatgac catccttttc cttactatgg ttatttcata ctttggttgc atgaaggctg     1140



cccccatgaa agaagcaaac atccgaggac aaggtggctt ggcctaccca ggtgtgcgga     1200



cccatgggac tctggagagc gtgaatgggc ccaaggcagg ttcaagaggc ttgacatcat     1260



tggctgacac tttcgaacac gtgatagaag agctgttgga tgaggaccag aaagttcggc     1320



ccaatgaaga aaacaataag gacgcagact tgtacacgtc cagggtgatg ctcagtagtc     1380



aagtgccttt ggagcctcct cttctctttc tgctggagga atacaaaaat tacctagatg     1440



ctgcaaacat gtccatgagg gtccggcgcc actctgaccc tgcccgccga ggggagctga     1500



gcgtgtgtga cagtattagt gagtgggtaa cggcggcaga caaaaagact gcagtggaca     1560



tgtcgggcgg gacggtcaca gtccttgaaa aggtccctgt atcaaaaggc caactgaagc     1620



aatacttcta cgagaccaag tgcaatccca tgggttacac aaaagaaggc tgcaggggca     1680



tagacaaaag gcattggaac tcccagtgcc gaactaccca gtcgtacgtg cgggccctta     1740



ccatggatag caaaaagaga attggctggc gattcataag gatagacact tcttgtgtat     1800



gtacattgac cattaaaagg ggaagatagt ggatttatgt tgtatagatt agattatatt     1860



gagacaaaaa ttatctattt gtatatatac ataacagggt aaattattca gttaagaaaa     1920



aaataatttt atgaactgca tgtataaatg aagtttatac agtacagtgg ttctacaatc     1980



tatttattgg acatgtccat gaccagaagg gaaacagtca tttgcgcaca acttaaaaag     2040



tctgcattac attccttgat aatgttgtgg tttgttgccg ttgccaagaa ctgaaaacat     2100



aaaaagttaa aaaaaataat aaattgcatg ctgctttaat tgtgaattga taataaactg     2160



tcctctttca gaaaacagaa aaaaacacac acacacacaa caaaaatttg aaccaaaaca     2220



ttccgtttac attttagaca gtaagtatct tcgttcttgt tagtactata tctgttttac     2280



tgcttttaac ttctgatagc gttggaatta aaacaatgtc aaggtgctgt tgtcattgct     2340



ttactggctt aggggatggg ggatgggggg tatatttttg tttgttttgt gttttttttt     2400



cgtttgtttg ttttgttttt tagttcccac agggagtaga gatggggaaa gaattcctac     2460



aatatatatt ctggctgata aaagatacat ttgtatgttg tgaagatgtt tgcaatatcg     2520



atcagatgac tagaaagtga ataaaaatta aggcaactga acaaaaaaat gctcacactc     2580



cacatcccgt gatgcacctc ccaggccccg ctcattcttt gggcgttggt cagagtaagc     2640



tgcttttgac ggaaggacct atgtttgctc agaacacatt ctttcccccc ctccccctct     2700



ggtctcctct ttgttttgtt ttaaggaaga aaaatcagtt gcgcgttctg aaatatttta     2760



ccactgctgt gaacaagtga acacattgtg tcacatcatg acactcgtat aagcatggag     2820



aacagtgatt tttttttaga acagaaaaca acaaaaaata accccaaaat gaagattatt     2880



ttttatgagg agtgaacatt tgggtaaatc atggctaagc ttaaaaaaaa ctcatggtga     2940



ggcttaacaa tgtcttgtaa gcaaaaggta gagccctgta tcaacccaga aacacctaga     3000



tcagaacagg aatccacatt gccagtgaca tgagactgaa cagccaaatg gaggctatgt     3060



ggagttggca ttgcatttac cggcagtgcg ggaggaattt ctgagtggcc atcccaaggt     3120



ctaggtggag gtggggcatg gtatttgaga cattccaaaa cgaaggcctc tgaaggaccc     3180



ttcagaggtg gctctggaat gacatgtgtc aagctgcttg gacctcgtgc tttaagtgcc     3240



tacattatct aactgtgctc aagaggttct cgactggagg accacactca agccgactta     3300



tgcccaccat cccacctctg gataattttg cataaaattg gattagcctg gagcaggttg     3360



ggagccaaat gtggcatttg tgatcatgag attgatgcaa tgagatagaa gatgtttgct     3420



acctgaacac ttattgcttt gaaactagac ttgaggaaac cagggtttat cttttgagaa     3480



cttttggtaa gggaaaaggg aacaggaaaa gaaaccccaa actcaggccg aatgatcaag     3540



gggacccata ggaaatcttg tccagagaca agacttcggg aaggtgtctg gacattcaga     3600



acaccaagac ttgaaggtgc cttgctcaat ggaagaggcc aggacagagc tgacaaaatt     3660



ttgctcccca gtgaaggcca cagcaacctt ctgcccatcc tgtctgttca tggagagggt     3720



ccctgcctca cctctgccat tttgggttag gagaagtcaa gttgggagcc tgaaatagtg     3780



gttcttggaa aaatggatcc ccagtgaaaa ctagagctct aagcccattc agcccatttc     3840



acacctgaaa atgttagtga tcaccacttg gaccagcatc cttaagtatc agaaagcccc     3900



aagcaattgc tgcatcttag tagggtgagg gataagcaaa agaggatgtt caccataacc     3960



caggaatgaa gataccatca gcaaagaatt tcaatttgtt cagtctttca tttagagcta     4020



gtctttcaca gtaccatctg aatacctctt tgaaagaagg aagactttac gtagtgtaga     4080



tttgttttgt gttgtttgaa aatattatct ttgtaattat ttttaatatg taaggaatgc     4140



ttggaatatc tgctatatgt caactttatg cagcttcctt ttgagggaca aatttaaaac     4200



aaacaacccc ccatcacaaa cttaaaggat tgcaagggcc agatctgtta agtggtttca     4260



taggagacac atccagcaat tgtgtggtca gtggctcttt tacccaataa gatacatcac     4320



agtcacatgc ttgatggttt atgttgacct aagatttatt ttgttaaaat ctctctctgt     4380



tgtgttcgtt cttgttctgt tttgttttgt tttttaaagt cttgctgtgg tctctttgtg     4440



gcagaagtgt ttcatgcatg gcagcaggcc tgttgctttt ttatggcgat tcccattgaa     4500



aatgtaagta aatgtctgtg gccttgttct ctctatggta aagatattat tcaccatgta     4560



aaacaaaaaa caatatttat tgtattttag tatatttata taattatgtt attgaaaaaa     4620



attggcatta aaacttaacc gcatcagaac ctattgtaaa tacaagttct atttaagtgt     4680



actaattaac atataatata tgttttaaat atagaatttt taatgttttt aaatatattt     4740



tcaaagtaca taaaa                                                      4755





<210>  17

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  17



Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 

1               5                   10                  15      





Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 

            20                  25                  30          





Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 

        35                  40                  45              





Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 

    50                  55                  60                  





His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 

65                  70                  75                  80  





Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 

                85                  90                  95      





Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 

            100                 105                 110         





Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 

        115                 120                 125             





His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 

    130                 135                 140                 





Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 

145                 150                 155                 160 





Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 

                165                 170                 175     





Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 

            180                 185                 190         





Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 

        195                 200                 205             





Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 

    210                 215                 220                 





Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 

225                 230                 235                 240 





Leu Thr Ile Lys Arg Gly Arg 

                245         





<210>  18

<211>  3976

<212>  DNA

<213>  Homo sapiens



<400>  18

acacggctac ctgctcccag gaattgagac tgaagtggac ttacaagtcc gaagccaatg       60



tagcttggaa aacttgggag gcggaattcc taccgctggg aactgaaagg gtctgcgaca      120



ctctcgggca ggccgaaccc acatctctac ccatcctgcg cccctcttct gaagcgccct      180



ccagggaagt taagagtttt gactttcggg gagtggttgg gatgtacgtg ggggattctt      240



gactcgggtt agtctctggg gatgcagagc cgggaagagg aatggttcca ccaggtgaga      300



agagtgatga ccatcctttt ccttactatg gttatttcat actttggttg catgaaggct      360



gcccccatga aagaagcaaa catccgagga caaggtggct tggcctaccc aggtgtgcgg      420



acccatggga ctctggagag cgtgaatggg cccaaggcag gttcaagagg cttgacatca      480



ttggctgaca ctttcgaaca cgtgatagaa gagctgttgg atgaggacca gaaagttcgg      540



cccaatgaag aaaacaataa ggacgcagac ttgtacacgt ccagggtgat gctcagtagt      600



caagtgcctt tggagcctcc tcttctcttt ctgctggagg aatacaaaaa ttacctagat      660



gctgcaaaca tgtccatgag ggtccggcgc cactctgacc ctgcccgccg aggggagctg      720



agcgtgtgtg acagtattag tgagtgggta acggcggcag acaaaaagac tgcagtggac      780



atgtcgggcg ggacggtcac agtccttgaa aaggtccctg tatcaaaagg ccaactgaag      840



caatacttct acgagaccaa gtgcaatccc atgggttaca caaaagaagg ctgcaggggc      900



atagacaaaa ggcattggaa ctcccagtgc cgaactaccc agtcgtacgt gcgggccctt      960



accatggata gcaaaaagag aattggctgg cgattcataa ggatagacac ttcttgtgta     1020



tgtacattga ccattaaaag gggaagatag tggatttatg ttgtatagat tagattatat     1080



tgagacaaaa attatctatt tgtatatata cataacaggg taaattattc agttaagaaa     1140



aaaataattt tatgaactgc atgtataaat gaagtttata cagtacagtg gttctacaat     1200



ctatttattg gacatgtcca tgaccagaag ggaaacagtc atttgcgcac aacttaaaaa     1260



gtctgcatta cattccttga taatgttgtg gtttgttgcc gttgccaaga actgaaaaca     1320



taaaaagtta aaaaaaataa taaattgcat gctgctttaa ttgtgaattg ataataaact     1380



gtcctctttc agaaaacaga aaaaaacaca cacacacaca acaaaaattt gaaccaaaac     1440



attccgttta cattttagac agtaagtatc ttcgttcttg ttagtactat atctgtttta     1500



ctgcttttaa cttctgatag cgttggaatt aaaacaatgt caaggtgctg ttgtcattgc     1560



tttactggct taggggatgg gggatggggg gtatattttt gtttgttttg tgtttttttt     1620



tcgtttgttt gttttgtttt ttagttccca cagggagtag agatggggaa agaattccta     1680



caatatatat tctggctgat aaaagataca tttgtatgtt gtgaagatgt ttgcaatatc     1740



gatcagatga ctagaaagtg aataaaaatt aaggcaactg aacaaaaaaa tgctcacact     1800



ccacatcccg tgatgcacct cccaggcccc gctcattctt tgggcgttgg tcagagtaag     1860



ctgcttttga cggaaggacc tatgtttgct cagaacacat tctttccccc cctccccctc     1920



tggtctcctc tttgttttgt tttaaggaag aaaaatcagt tgcgcgttct gaaatatttt     1980



accactgctg tgaacaagtg aacacattgt gtcacatcat gacactcgta taagcatgga     2040



gaacagtgat ttttttttag aacagaaaac aacaaaaaat aaccccaaaa tgaagattat     2100



tttttatgag gagtgaacat ttgggtaaat catggctaag cttaaaaaaa actcatggtg     2160



aggcttaaca atgtcttgta agcaaaaggt agagccctgt atcaacccag aaacacctag     2220



atcagaacag gaatccacat tgccagtgac atgagactga acagccaaat ggaggctatg     2280



tggagttggc attgcattta ccggcagtgc gggaggaatt tctgagtggc catcccaagg     2340



tctaggtgga ggtggggcat ggtatttgag acattccaaa acgaaggcct ctgaaggacc     2400



cttcagaggt ggctctggaa tgacatgtgt caagctgctt ggacctcgtg ctttaagtgc     2460



ctacattatc taactgtgct caagaggttc tcgactggag gaccacactc aagccgactt     2520



atgcccacca tcccacctct ggataatttt gcataaaatt ggattagcct ggagcaggtt     2580



gggagccaaa tgtggcattt gtgatcatga gattgatgca atgagataga agatgtttgc     2640



tacctgaaca cttattgctt tgaaactaga cttgaggaaa ccagggttta tcttttgaga     2700



acttttggta agggaaaagg gaacaggaaa agaaacccca aactcaggcc gaatgatcaa     2760



ggggacccat aggaaatctt gtccagagac aagacttcgg gaaggtgtct ggacattcag     2820



aacaccaaga cttgaaggtg ccttgctcaa tggaagaggc caggacagag ctgacaaaat     2880



tttgctcccc agtgaaggcc acagcaacct tctgcccatc ctgtctgttc atggagaggg     2940



tccctgcctc acctctgcca ttttgggtta ggagaagtca agttgggagc ctgaaatagt     3000



ggttcttgga aaaatggatc cccagtgaaa actagagctc taagcccatt cagcccattt     3060



cacacctgaa aatgttagtg atcaccactt ggaccagcat ccttaagtat cagaaagccc     3120



caagcaattg ctgcatctta gtagggtgag ggataagcaa aagaggatgt tcaccataac     3180



ccaggaatga agataccatc agcaaagaat ttcaatttgt tcagtctttc atttagagct     3240



agtctttcac agtaccatct gaatacctct ttgaaagaag gaagacttta cgtagtgtag     3300



atttgttttg tgttgtttga aaatattatc tttgtaatta tttttaatat gtaaggaatg     3360



cttggaatat ctgctatatg tcaactttat gcagcttcct tttgagggac aaatttaaaa     3420



caaacaaccc cccatcacaa acttaaagga ttgcaagggc cagatctgtt aagtggtttc     3480



ataggagaca catccagcaa ttgtgtggtc agtggctctt ttacccaata agatacatca     3540



cagtcacatg cttgatggtt tatgttgacc taagatttat tttgttaaaa tctctctctg     3600



ttgtgttcgt tcttgttctg ttttgttttg ttttttaaag tcttgctgtg gtctctttgt     3660



ggcagaagtg tttcatgcat ggcagcaggc ctgttgcttt tttatggcga ttcccattga     3720



aaatgtaagt aaatgtctgt ggccttgttc tctctatggt aaagatatta ttcaccatgt     3780



aaaacaaaaa acaatattta ttgtatttta gtatatttat ataattatgt tattgaaaaa     3840



aattggcatt aaaacttaac cgcatcagaa cctattgtaa atacaagttc tatttaagtg     3900



tactaattaa catataatat atgttttaaa tatagaattt ttaatgtttt taaatatatt     3960



ttcaaagtac ataaaa                                                     3976





<210>  19

<211>  262

<212>  PRT

<213>  Homo sapiens



<400>  19



Met Gln Ser Arg Glu Glu Glu Trp Phe His Gln Val Arg Arg Val Met 

1               5                   10                  15      





Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met Lys 

            20                  25                  30          





Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu Ala 

        35                  40                  45              





Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly Pro 

    50                  55                  60                  





Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu His 

65                  70                  75                  80  





Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn Glu 

                85                  90                  95      





Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu Ser 

            100                 105                 110         





Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu Tyr 

        115                 120                 125             





Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg His 

    130                 135                 140                 





Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile Ser 

145                 150                 155                 160 





Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser Gly 

                165                 170                 175     





Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln Leu 

            180                 185                 190         





Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr Lys 

        195                 200                 205             





Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys Arg 

    210                 215                 220                 





Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys Arg 

225                 230                 235                 240 





Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr Leu 

                245                 250                 255     





Thr Ile Lys Arg Gly Arg 

            260         





<210>  20

<211>  4028

<212>  DNA

<213>  Homo sapiens



<400>  20

acccactttc ccattcaccg cggagagggc tgctctcgct gccgctcccc ccggcgaact       60



agcatgaaat ctccctgcct ctgccgagat caaatggagc ttctcgctga tggggtgcga      120



gtattacctc cgccatgcaa tttccactat caataattta acttctttgc tgcagaacag      180



aaggagtaca taccgggcac caaagactcg cgccccctcc cccctttaat taagcgaagg      240



gaacgtgaaa aaataataga gtgtgggagt tttggggccg aagtctttcc cggagcagct      300



gccttgatgg ttactttgac aagtagtgac tgaaaagttc caccaggtga gaagagtgat      360



gaccatcctt ttccttacta tggttatttc atactttggt tgcatgaagg ctgcccccat      420



gaaagaagca aacatccgag gacaaggtgg cttggcctac ccaggtgtgc ggacccatgg      480



gactctggag agcgtgaatg ggcccaaggc aggttcaaga ggcttgacat cattggctga      540



cactttcgaa cacgtgatag aagagctgtt ggatgaggac cagaaagttc ggcccaatga      600



agaaaacaat aaggacgcag acttgtacac gtccagggtg atgctcagta gtcaagtgcc      660



tttggagcct cctcttctct ttctgctgga ggaatacaaa aattacctag atgctgcaaa      720



catgtccatg agggtccggc gccactctga ccctgcccgc cgaggggagc tgagcgtgtg      780



tgacagtatt agtgagtggg taacggcggc agacaaaaag actgcagtgg acatgtcggg      840



cgggacggtc acagtccttg aaaaggtccc tgtatcaaaa ggccaactga agcaatactt      900



ctacgagacc aagtgcaatc ccatgggtta cacaaaagaa ggctgcaggg gcatagacaa      960



aaggcattgg aactcccagt gccgaactac ccagtcgtac gtgcgggccc ttaccatgga     1020



tagcaaaaag agaattggct ggcgattcat aaggatagac acttcttgtg tatgtacatt     1080



gaccattaaa aggggaagat agtggattta tgttgtatag attagattat attgagacaa     1140



aaattatcta tttgtatata tacataacag ggtaaattat tcagttaaga aaaaaataat     1200



tttatgaact gcatgtataa atgaagttta tacagtacag tggttctaca atctatttat     1260



tggacatgtc catgaccaga agggaaacag tcatttgcgc acaacttaaa aagtctgcat     1320



tacattcctt gataatgttg tggtttgttg ccgttgccaa gaactgaaaa cataaaaagt     1380



taaaaaaaat aataaattgc atgctgcttt aattgtgaat tgataataaa ctgtcctctt     1440



tcagaaaaca gaaaaaaaca cacacacaca caacaaaaat ttgaaccaaa acattccgtt     1500



tacattttag acagtaagta tcttcgttct tgttagtact atatctgttt tactgctttt     1560



aacttctgat agcgttggaa ttaaaacaat gtcaaggtgc tgttgtcatt gctttactgg     1620



cttaggggat gggggatggg gggtatattt ttgtttgttt tgtgtttttt tttcgtttgt     1680



ttgttttgtt ttttagttcc cacagggagt agagatgggg aaagaattcc tacaatatat     1740



attctggctg ataaaagata catttgtatg ttgtgaagat gtttgcaata tcgatcagat     1800



gactagaaag tgaataaaaa ttaaggcaac tgaacaaaaa aatgctcaca ctccacatcc     1860



cgtgatgcac ctcccaggcc ccgctcattc tttgggcgtt ggtcagagta agctgctttt     1920



gacggaagga cctatgtttg ctcagaacac attctttccc cccctccccc tctggtctcc     1980



tctttgtttt gttttaagga agaaaaatca gttgcgcgtt ctgaaatatt ttaccactgc     2040



tgtgaacaag tgaacacatt gtgtcacatc atgacactcg tataagcatg gagaacagtg     2100



attttttttt agaacagaaa acaacaaaaa ataaccccaa aatgaagatt attttttatg     2160



aggagtgaac atttgggtaa atcatggcta agcttaaaaa aaactcatgg tgaggcttaa     2220



caatgtcttg taagcaaaag gtagagccct gtatcaaccc agaaacacct agatcagaac     2280



aggaatccac attgccagtg acatgagact gaacagccaa atggaggcta tgtggagttg     2340



gcattgcatt taccggcagt gcgggaggaa tttctgagtg gccatcccaa ggtctaggtg     2400



gaggtggggc atggtatttg agacattcca aaacgaaggc ctctgaagga cccttcagag     2460



gtggctctgg aatgacatgt gtcaagctgc ttggacctcg tgctttaagt gcctacatta     2520



tctaactgtg ctcaagaggt tctcgactgg aggaccacac tcaagccgac ttatgcccac     2580



catcccacct ctggataatt ttgcataaaa ttggattagc ctggagcagg ttgggagcca     2640



aatgtggcat ttgtgatcat gagattgatg caatgagata gaagatgttt gctacctgaa     2700



cacttattgc tttgaaacta gacttgagga aaccagggtt tatcttttga gaacttttgg     2760



taagggaaaa gggaacagga aaagaaaccc caaactcagg ccgaatgatc aaggggaccc     2820



ataggaaatc ttgtccagag acaagacttc gggaaggtgt ctggacattc agaacaccaa     2880



gacttgaagg tgccttgctc aatggaagag gccaggacag agctgacaaa attttgctcc     2940



ccagtgaagg ccacagcaac cttctgccca tcctgtctgt tcatggagag ggtccctgcc     3000



tcacctctgc cattttgggt taggagaagt caagttggga gcctgaaata gtggttcttg     3060



gaaaaatgga tccccagtga aaactagagc tctaagccca ttcagcccat ttcacacctg     3120



aaaatgttag tgatcaccac ttggaccagc atccttaagt atcagaaagc cccaagcaat     3180



tgctgcatct tagtagggtg agggataagc aaaagaggat gttcaccata acccaggaat     3240



gaagatacca tcagcaaaga atttcaattt gttcagtctt tcatttagag ctagtctttc     3300



acagtaccat ctgaatacct ctttgaaaga aggaagactt tacgtagtgt agatttgttt     3360



tgtgttgttt gaaaatatta tctttgtaat tatttttaat atgtaaggaa tgcttggaat     3420



atctgctata tgtcaacttt atgcagcttc cttttgaggg acaaatttaa aacaaacaac     3480



cccccatcac aaacttaaag gattgcaagg gccagatctg ttaagtggtt tcataggaga     3540



cacatccagc aattgtgtgg tcagtggctc ttttacccaa taagatacat cacagtcaca     3600



tgcttgatgg tttatgttga cctaagattt attttgttaa aatctctctc tgttgtgttc     3660



gttcttgttc tgttttgttt tgttttttaa agtcttgctg tggtctcttt gtggcagaag     3720



tgtttcatgc atggcagcag gcctgttgct tttttatggc gattcccatt gaaaatgtaa     3780



gtaaatgtct gtggccttgt tctctctatg gtaaagatat tattcaccat gtaaaacaaa     3840



aaacaatatt tattgtattt tagtatattt atataattat gttattgaaa aaaattggca     3900



ttaaaactta accgcatcag aacctattgt aaatacaagt tctatttaag tgtactaatt     3960



aacatataat atatgtttta aatatagaat ttttaatgtt tttaaatata ttttcaaagt     4020



acataaaa                                                              4028





<210>  21

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  21



Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 

1               5                   10                  15      





Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 

            20                  25                  30          





Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 

        35                  40                  45              





Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 

    50                  55                  60                  





His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 

65                  70                  75                  80  





Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 

                85                  90                  95      





Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 

            100                 105                 110         





Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 

        115                 120                 125             





His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 

    130                 135                 140                 





Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 

145                 150                 155                 160 





Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 

                165                 170                 175     





Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 

            180                 185                 190         





Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 

        195                 200                 205             





Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 

    210                 215                 220                 





Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 

225                 230                 235                 240 





Leu Thr Ile Lys Arg Gly Arg 

                245         





<210>  22

<211>  4125

<212>  DNA

<213>  Homo sapiens



<400>  22

aatatcaagt atcacttaat tagagatttt taagcctttt cctcctgctg tgccgggtgt       60



gtaatccggg cgataggagt ccattcagca ccttggacag agccaacgga tttgtccgag      120



gtggcggtac ccccaggtag tcttcttggc cccgctgtaa agccaaccct gtgtcgccct      180



taaaaagcgt cttttctgag gttcggctca cactgagatc ggggctggag agagagtcag      240



attttggagc ggagcgtttg gaaagcgagc cccagtttgg tcccctcatt gagctcgctg      300



aagttggctt cctagcggtg taggctggaa tagactcttg gcaagctccg ggttggtata      360



ctgggttaac tttgggaaat gcaagtgttt atctccagga tctagccacc ggggtggtgt      420



aagccgcaaa gaagttccac caggtgagaa gagtgatgac catccttttc cttactatgg      480



ttatttcata ctttggttgc atgaaggctg cccccatgaa agaagcaaac atccgaggac      540



aaggtggctt ggcctaccca ggtgtgcgga cccatgggac tctggagagc gtgaatgggc      600



ccaaggcagg ttcaagaggc ttgacatcat tggctgacac tttcgaacac gtgatagaag      660



agctgttgga tgaggaccag aaagttcggc ccaatgaaga aaacaataag gacgcagact      720



tgtacacgtc cagggtgatg ctcagtagtc aagtgccttt ggagcctcct cttctctttc      780



tgctggagga atacaaaaat tacctagatg ctgcaaacat gtccatgagg gtccggcgcc      840



actctgaccc tgcccgccga ggggagctga gcgtgtgtga cagtattagt gagtgggtaa      900



cggcggcaga caaaaagact gcagtggaca tgtcgggcgg gacggtcaca gtccttgaaa      960



aggtccctgt atcaaaaggc caactgaagc aatacttcta cgagaccaag tgcaatccca     1020



tgggttacac aaaagaaggc tgcaggggca tagacaaaag gcattggaac tcccagtgcc     1080



gaactaccca gtcgtacgtg cgggccctta ccatggatag caaaaagaga attggctggc     1140



gattcataag gatagacact tcttgtgtat gtacattgac cattaaaagg ggaagatagt     1200



ggatttatgt tgtatagatt agattatatt gagacaaaaa ttatctattt gtatatatac     1260



ataacagggt aaattattca gttaagaaaa aaataatttt atgaactgca tgtataaatg     1320



aagtttatac agtacagtgg ttctacaatc tatttattgg acatgtccat gaccagaagg     1380



gaaacagtca tttgcgcaca acttaaaaag tctgcattac attccttgat aatgttgtgg     1440



tttgttgccg ttgccaagaa ctgaaaacat aaaaagttaa aaaaaataat aaattgcatg     1500



ctgctttaat tgtgaattga taataaactg tcctctttca gaaaacagaa aaaaacacac     1560



acacacacaa caaaaatttg aaccaaaaca ttccgtttac attttagaca gtaagtatct     1620



tcgttcttgt tagtactata tctgttttac tgcttttaac ttctgatagc gttggaatta     1680



aaacaatgtc aaggtgctgt tgtcattgct ttactggctt aggggatggg ggatgggggg     1740



tatatttttg tttgttttgt gttttttttt cgtttgtttg ttttgttttt tagttcccac     1800



agggagtaga gatggggaaa gaattcctac aatatatatt ctggctgata aaagatacat     1860



ttgtatgttg tgaagatgtt tgcaatatcg atcagatgac tagaaagtga ataaaaatta     1920



aggcaactga acaaaaaaat gctcacactc cacatcccgt gatgcacctc ccaggccccg     1980



ctcattcttt gggcgttggt cagagtaagc tgcttttgac ggaaggacct atgtttgctc     2040



agaacacatt ctttcccccc ctccccctct ggtctcctct ttgttttgtt ttaaggaaga     2100



aaaatcagtt gcgcgttctg aaatatttta ccactgctgt gaacaagtga acacattgtg     2160



tcacatcatg acactcgtat aagcatggag aacagtgatt tttttttaga acagaaaaca     2220



acaaaaaata accccaaaat gaagattatt ttttatgagg agtgaacatt tgggtaaatc     2280



atggctaagc ttaaaaaaaa ctcatggtga ggcttaacaa tgtcttgtaa gcaaaaggta     2340



gagccctgta tcaacccaga aacacctaga tcagaacagg aatccacatt gccagtgaca     2400



tgagactgaa cagccaaatg gaggctatgt ggagttggca ttgcatttac cggcagtgcg     2460



ggaggaattt ctgagtggcc atcccaaggt ctaggtggag gtggggcatg gtatttgaga     2520



cattccaaaa cgaaggcctc tgaaggaccc ttcagaggtg gctctggaat gacatgtgtc     2580



aagctgcttg gacctcgtgc tttaagtgcc tacattatct aactgtgctc aagaggttct     2640



cgactggagg accacactca agccgactta tgcccaccat cccacctctg gataattttg     2700



cataaaattg gattagcctg gagcaggttg ggagccaaat gtggcatttg tgatcatgag     2760



attgatgcaa tgagatagaa gatgtttgct acctgaacac ttattgcttt gaaactagac     2820



ttgaggaaac cagggtttat cttttgagaa cttttggtaa gggaaaaggg aacaggaaaa     2880



gaaaccccaa actcaggccg aatgatcaag gggacccata ggaaatcttg tccagagaca     2940



agacttcggg aaggtgtctg gacattcaga acaccaagac ttgaaggtgc cttgctcaat     3000



ggaagaggcc aggacagagc tgacaaaatt ttgctcccca gtgaaggcca cagcaacctt     3060



ctgcccatcc tgtctgttca tggagagggt ccctgcctca cctctgccat tttgggttag     3120



gagaagtcaa gttgggagcc tgaaatagtg gttcttggaa aaatggatcc ccagtgaaaa     3180



ctagagctct aagcccattc agcccatttc acacctgaaa atgttagtga tcaccacttg     3240



gaccagcatc cttaagtatc agaaagcccc aagcaattgc tgcatcttag tagggtgagg     3300



gataagcaaa agaggatgtt caccataacc caggaatgaa gataccatca gcaaagaatt     3360



tcaatttgtt cagtctttca tttagagcta gtctttcaca gtaccatctg aatacctctt     3420



tgaaagaagg aagactttac gtagtgtaga tttgttttgt gttgtttgaa aatattatct     3480



ttgtaattat ttttaatatg taaggaatgc ttggaatatc tgctatatgt caactttatg     3540



cagcttcctt ttgagggaca aatttaaaac aaacaacccc ccatcacaaa cttaaaggat     3600



tgcaagggcc agatctgtta agtggtttca taggagacac atccagcaat tgtgtggtca     3660



gtggctcttt tacccaataa gatacatcac agtcacatgc ttgatggttt atgttgacct     3720



aagatttatt ttgttaaaat ctctctctgt tgtgttcgtt cttgttctgt tttgttttgt     3780



tttttaaagt cttgctgtgg tctctttgtg gcagaagtgt ttcatgcatg gcagcaggcc     3840



tgttgctttt ttatggcgat tcccattgaa aatgtaagta aatgtctgtg gccttgttct     3900



ctctatggta aagatattat tcaccatgta aaacaaaaaa caatatttat tgtattttag     3960



tatatttata taattatgtt attgaaaaaa attggcatta aaacttaacc gcatcagaac     4020



ctattgtaaa tacaagttct atttaagtgt actaattaac atataatata tgttttaaat     4080



atagaatttt taatgttttt aaatatattt tcaaagtaca taaaa                     4125





<210>  23

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  23



Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 

1               5                   10                  15      





Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 

            20                  25                  30          





Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 

        35                  40                  45              





Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 

    50                  55                  60                  





His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 

65                  70                  75                  80  





Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 

                85                  90                  95      





Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 

            100                 105                 110         





Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 

        115                 120                 125             





His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 

    130                 135                 140                 





Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 

145                 150                 155                 160 





Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 

                165                 170                 175     





Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 

            180                 185                 190         





Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 

        195                 200                 205             





Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 

    210                 215                 220                 





Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 

225                 230                 235                 240 





Leu Thr Ile Lys Arg Gly Arg 

                245         





<210>  24

<211>  4338

<212>  DNA

<213>  Homo sapiens



<400>  24

attattaaag cggtagtctg ccggcgctga taagcaacaa gttccccagc ggtcttcccg       60



ccctagcctg acaaggcgaa ggttttctta cctggcgaca gggaaatctc ccgagccgaa      120



ttcagcttcg ccggagcccc aggtgtgacc tgcgtagtgg gcaagggagc ggtgtgcagg      180



ctgagttttt ttttttacag gggtaccctg aaactcctca ctttctctgg gaactttcag      240



tgccaggacc cagtaacggg cggttagaag gcagccctag gaaacacctg ctacatagca      300



gggcagttgg gcaatcattg gtaacctcgc tcattcatta gaatcacgta agaactcaaa      360



aggaaacgtg tctctcggag tgagggcgtt tgcgtaaatc tataggtttt tcgacatcga      420



tgccagttgc tttgtcttct gtagtcgcca aggtggttga gagtttaagc ttgcggatat      480



tgcaaagggt tattagattc ataagtcaca ccaagtggtg ggcgatccac tgagcaaagc      540



cgaacttctc acatgatgac ttcaaacaag acacattacc ttccagcatc tgttggggag      600



acgagatttt aagacacttg agtctccagg acagcaaagg cacaatgttc caccaggtga      660



gaagagtgat gaccatcctt ttccttacta tggttatttc atactttggt tgcatgaagg      720



ctgcccccat gaaagaagca aacatccgag gacaaggtgg cttggcctac ccaggtgtgc      780



ggacccatgg gactctggag agcgtgaatg ggcccaaggc aggttcaaga ggcttgacat      840



cattggctga cactttcgaa cacgtgatag aagagctgtt ggatgaggac cagaaagttc      900



ggcccaatga agaaaacaat aaggacgcag acttgtacac gtccagggtg atgctcagta      960



gtcaagtgcc tttggagcct cctcttctct ttctgctgga ggaatacaaa aattacctag     1020



atgctgcaaa catgtccatg agggtccggc gccactctga ccctgcccgc cgaggggagc     1080



tgagcgtgtg tgacagtatt agtgagtggg taacggcggc agacaaaaag actgcagtgg     1140



acatgtcggg cgggacggtc acagtccttg aaaaggtccc tgtatcaaaa ggccaactga     1200



agcaatactt ctacgagacc aagtgcaatc ccatgggtta cacaaaagaa ggctgcaggg     1260



gcatagacaa aaggcattgg aactcccagt gccgaactac ccagtcgtac gtgcgggccc     1320



ttaccatgga tagcaaaaag agaattggct ggcgattcat aaggatagac acttcttgtg     1380



tatgtacatt gaccattaaa aggggaagat agtggattta tgttgtatag attagattat     1440



attgagacaa aaattatcta tttgtatata tacataacag ggtaaattat tcagttaaga     1500



aaaaaataat tttatgaact gcatgtataa atgaagttta tacagtacag tggttctaca     1560



atctatttat tggacatgtc catgaccaga agggaaacag tcatttgcgc acaacttaaa     1620



aagtctgcat tacattcctt gataatgttg tggtttgttg ccgttgccaa gaactgaaaa     1680



cataaaaagt taaaaaaaat aataaattgc atgctgcttt aattgtgaat tgataataaa     1740



ctgtcctctt tcagaaaaca gaaaaaaaca cacacacaca caacaaaaat ttgaaccaaa     1800



acattccgtt tacattttag acagtaagta tcttcgttct tgttagtact atatctgttt     1860



tactgctttt aacttctgat agcgttggaa ttaaaacaat gtcaaggtgc tgttgtcatt     1920



gctttactgg cttaggggat gggggatggg gggtatattt ttgtttgttt tgtgtttttt     1980



tttcgtttgt ttgttttgtt ttttagttcc cacagggagt agagatgggg aaagaattcc     2040



tacaatatat attctggctg ataaaagata catttgtatg ttgtgaagat gtttgcaata     2100



tcgatcagat gactagaaag tgaataaaaa ttaaggcaac tgaacaaaaa aatgctcaca     2160



ctccacatcc cgtgatgcac ctcccaggcc ccgctcattc tttgggcgtt ggtcagagta     2220



agctgctttt gacggaagga cctatgtttg ctcagaacac attctttccc cccctccccc     2280



tctggtctcc tctttgtttt gttttaagga agaaaaatca gttgcgcgtt ctgaaatatt     2340



ttaccactgc tgtgaacaag tgaacacatt gtgtcacatc atgacactcg tataagcatg     2400



gagaacagtg attttttttt agaacagaaa acaacaaaaa ataaccccaa aatgaagatt     2460



attttttatg aggagtgaac atttgggtaa atcatggcta agcttaaaaa aaactcatgg     2520



tgaggcttaa caatgtcttg taagcaaaag gtagagccct gtatcaaccc agaaacacct     2580



agatcagaac aggaatccac attgccagtg acatgagact gaacagccaa atggaggcta     2640



tgtggagttg gcattgcatt taccggcagt gcgggaggaa tttctgagtg gccatcccaa     2700



ggtctaggtg gaggtggggc atggtatttg agacattcca aaacgaaggc ctctgaagga     2760



cccttcagag gtggctctgg aatgacatgt gtcaagctgc ttggacctcg tgctttaagt     2820



gcctacatta tctaactgtg ctcaagaggt tctcgactgg aggaccacac tcaagccgac     2880



ttatgcccac catcccacct ctggataatt ttgcataaaa ttggattagc ctggagcagg     2940



ttgggagcca aatgtggcat ttgtgatcat gagattgatg caatgagata gaagatgttt     3000



gctacctgaa cacttattgc tttgaaacta gacttgagga aaccagggtt tatcttttga     3060



gaacttttgg taagggaaaa gggaacagga aaagaaaccc caaactcagg ccgaatgatc     3120



aaggggaccc ataggaaatc ttgtccagag acaagacttc gggaaggtgt ctggacattc     3180



agaacaccaa gacttgaagg tgccttgctc aatggaagag gccaggacag agctgacaaa     3240



attttgctcc ccagtgaagg ccacagcaac cttctgccca tcctgtctgt tcatggagag     3300



ggtccctgcc tcacctctgc cattttgggt taggagaagt caagttggga gcctgaaata     3360



gtggttcttg gaaaaatgga tccccagtga aaactagagc tctaagccca ttcagcccat     3420



ttcacacctg aaaatgttag tgatcaccac ttggaccagc atccttaagt atcagaaagc     3480



cccaagcaat tgctgcatct tagtagggtg agggataagc aaaagaggat gttcaccata     3540



acccaggaat gaagatacca tcagcaaaga atttcaattt gttcagtctt tcatttagag     3600



ctagtctttc acagtaccat ctgaatacct ctttgaaaga aggaagactt tacgtagtgt     3660



agatttgttt tgtgttgttt gaaaatatta tctttgtaat tatttttaat atgtaaggaa     3720



tgcttggaat atctgctata tgtcaacttt atgcagcttc cttttgaggg acaaatttaa     3780



aacaaacaac cccccatcac aaacttaaag gattgcaagg gccagatctg ttaagtggtt     3840



tcataggaga cacatccagc aattgtgtgg tcagtggctc ttttacccaa taagatacat     3900



cacagtcaca tgcttgatgg tttatgttga cctaagattt attttgttaa aatctctctc     3960



tgttgtgttc gttcttgttc tgttttgttt tgttttttaa agtcttgctg tggtctcttt     4020



gtggcagaag tgtttcatgc atggcagcag gcctgttgct tttttatggc gattcccatt     4080



gaaaatgtaa gtaaatgtct gtggccttgt tctctctatg gtaaagatat tattcaccat     4140



gtaaaacaaa aaacaatatt tattgtattt tagtatattt atataattat gttattgaaa     4200



aaaattggca ttaaaactta accgcatcag aacctattgt aaatacaagt tctatttaag     4260



tgtactaatt aacatataat atatgtttta aatatagaat ttttaatgtt tttaaatata     4320



ttttcaaagt acataaaa                                                   4338





<210>  25

<211>  255

<212>  PRT

<213>  Homo sapiens



<400>  25



Met Phe His Gln Val Arg Arg Val Met Thr Ile Leu Phe Leu Thr Met 

1               5                   10                  15      





Val Ile Ser Tyr Phe Gly Cys Met Lys Ala Ala Pro Met Lys Glu Ala 

            20                  25                  30          





Asn Ile Arg Gly Gln Gly Gly Leu Ala Tyr Pro Gly Val Arg Thr His 

        35                  40                  45              





Gly Thr Leu Glu Ser Val Asn Gly Pro Lys Ala Gly Ser Arg Gly Leu 

    50                  55                  60                  





Thr Ser Leu Ala Asp Thr Phe Glu His Val Ile Glu Glu Leu Leu Asp 

65                  70                  75                  80  





Glu Asp Gln Lys Val Arg Pro Asn Glu Glu Asn Asn Lys Asp Ala Asp 

                85                  90                  95      





Leu Tyr Thr Ser Arg Val Met Leu Ser Ser Gln Val Pro Leu Glu Pro 

            100                 105                 110         





Pro Leu Leu Phe Leu Leu Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala 

        115                 120                 125             





Asn Met Ser Met Arg Val Arg Arg His Ser Asp Pro Ala Arg Arg Gly 

    130                 135                 140                 





Glu Leu Ser Val Cys Asp Ser Ile Ser Glu Trp Val Thr Ala Ala Asp 

145                 150                 155                 160 





Lys Lys Thr Ala Val Asp Met Ser Gly Gly Thr Val Thr Val Leu Glu 

                165                 170                 175     





Lys Val Pro Val Ser Lys Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr 

            180                 185                 190         





Lys Cys Asn Pro Met Gly Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp 

        195                 200                 205             





Lys Arg His Trp Asn Ser Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg 

    210                 215                 220                 





Ala Leu Thr Met Asp Ser Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg 

225                 230                 235                 240 





Ile Asp Thr Ser Cys Val Cys Thr Leu Thr Ile Lys Arg Gly Arg 

                245                 250                 255 





<210>  26

<211>  4016

<212>  DNA

<213>  Homo sapiens



<400>  26

agagctaaat aatgtctgac ccgggcgcaa ggcgcagcct ggagctccgg gtccccgccg       60



ctgccgccgc cgcgcccggg cgcacccgcc cgctcgctgt cccgcgcacc ccgtagcgcc      120



tcgggctccc gggccggaca gaggagccag cccggtgcgc ccctccacct cctgctcggg      180



gggctttaat gagacaccca ccgctgctgt ggggccggcg gggagcagca ccgcgacggg      240



gaccggggct gggcgctgga gccagaatcg gaaccacgat gtgactccgc cgccggggac      300



ccgtgaggtt tgtgtggacc ccgagttcca ccaggtgaga agagtgatga ccatcctttt      360



ccttactatg gttatttcat actttggttg catgaaggct gcccccatga aagaagcaaa      420



catccgagga caaggtggct tggcctaccc aggtgtgcgg acccatggga ctctggagag      480



cgtgaatggg cccaaggcag gttcaagagg cttgacatca ttggctgaca ctttcgaaca      540



cgtgatagaa gagctgttgg atgaggacca gaaagttcgg cccaatgaag aaaacaataa      600



ggacgcagac ttgtacacgt ccagggtgat gctcagtagt caagtgcctt tggagcctcc      660



tcttctcttt ctgctggagg aatacaaaaa ttacctagat gctgcaaaca tgtccatgag      720



ggtccggcgc cactctgacc ctgcccgccg aggggagctg agcgtgtgtg acagtattag      780



tgagtgggta acggcggcag acaaaaagac tgcagtggac atgtcgggcg ggacggtcac      840



agtccttgaa aaggtccctg tatcaaaagg ccaactgaag caatacttct acgagaccaa      900



gtgcaatccc atgggttaca caaaagaagg ctgcaggggc atagacaaaa ggcattggaa      960



ctcccagtgc cgaactaccc agtcgtacgt gcgggccctt accatggata gcaaaaagag     1020



aattggctgg cgattcataa ggatagacac ttcttgtgta tgtacattga ccattaaaag     1080



gggaagatag tggatttatg ttgtatagat tagattatat tgagacaaaa attatctatt     1140



tgtatatata cataacaggg taaattattc agttaagaaa aaaataattt tatgaactgc     1200



atgtataaat gaagtttata cagtacagtg gttctacaat ctatttattg gacatgtcca     1260



tgaccagaag ggaaacagtc atttgcgcac aacttaaaaa gtctgcatta cattccttga     1320



taatgttgtg gtttgttgcc gttgccaaga actgaaaaca taaaaagtta aaaaaaataa     1380



taaattgcat gctgctttaa ttgtgaattg ataataaact gtcctctttc agaaaacaga     1440



aaaaaacaca cacacacaca acaaaaattt gaaccaaaac attccgttta cattttagac     1500



agtaagtatc ttcgttcttg ttagtactat atctgtttta ctgcttttaa cttctgatag     1560



cgttggaatt aaaacaatgt caaggtgctg ttgtcattgc tttactggct taggggatgg     1620



gggatggggg gtatattttt gtttgttttg tgtttttttt tcgtttgttt gttttgtttt     1680



ttagttccca cagggagtag agatggggaa agaattccta caatatatat tctggctgat     1740



aaaagataca tttgtatgtt gtgaagatgt ttgcaatatc gatcagatga ctagaaagtg     1800



aataaaaatt aaggcaactg aacaaaaaaa tgctcacact ccacatcccg tgatgcacct     1860



cccaggcccc gctcattctt tgggcgttgg tcagagtaag ctgcttttga cggaaggacc     1920



tatgtttgct cagaacacat tctttccccc cctccccctc tggtctcctc tttgttttgt     1980



tttaaggaag aaaaatcagt tgcgcgttct gaaatatttt accactgctg tgaacaagtg     2040



aacacattgt gtcacatcat gacactcgta taagcatgga gaacagtgat ttttttttag     2100



aacagaaaac aacaaaaaat aaccccaaaa tgaagattat tttttatgag gagtgaacat     2160



ttgggtaaat catggctaag cttaaaaaaa actcatggtg aggcttaaca atgtcttgta     2220



agcaaaaggt agagccctgt atcaacccag aaacacctag atcagaacag gaatccacat     2280



tgccagtgac atgagactga acagccaaat ggaggctatg tggagttggc attgcattta     2340



ccggcagtgc gggaggaatt tctgagtggc catcccaagg tctaggtgga ggtggggcat     2400



ggtatttgag acattccaaa acgaaggcct ctgaaggacc cttcagaggt ggctctggaa     2460



tgacatgtgt caagctgctt ggacctcgtg ctttaagtgc ctacattatc taactgtgct     2520



caagaggttc tcgactggag gaccacactc aagccgactt atgcccacca tcccacctct     2580



ggataatttt gcataaaatt ggattagcct ggagcaggtt gggagccaaa tgtggcattt     2640



gtgatcatga gattgatgca atgagataga agatgtttgc tacctgaaca cttattgctt     2700



tgaaactaga cttgaggaaa ccagggttta tcttttgaga acttttggta agggaaaagg     2760



gaacaggaaa agaaacccca aactcaggcc gaatgatcaa ggggacccat aggaaatctt     2820



gtccagagac aagacttcgg gaaggtgtct ggacattcag aacaccaaga cttgaaggtg     2880



ccttgctcaa tggaagaggc caggacagag ctgacaaaat tttgctcccc agtgaaggcc     2940



acagcaacct tctgcccatc ctgtctgttc atggagaggg tccctgcctc acctctgcca     3000



ttttgggtta ggagaagtca agttgggagc ctgaaatagt ggttcttgga aaaatggatc     3060



cccagtgaaa actagagctc taagcccatt cagcccattt cacacctgaa aatgttagtg     3120



atcaccactt ggaccagcat ccttaagtat cagaaagccc caagcaattg ctgcatctta     3180



gtagggtgag ggataagcaa aagaggatgt tcaccataac ccaggaatga agataccatc     3240



agcaaagaat ttcaatttgt tcagtctttc atttagagct agtctttcac agtaccatct     3300



gaatacctct ttgaaagaag gaagacttta cgtagtgtag atttgttttg tgttgtttga     3360



aaatattatc tttgtaatta tttttaatat gtaaggaatg cttggaatat ctgctatatg     3420



tcaactttat gcagcttcct tttgagggac aaatttaaaa caaacaaccc cccatcacaa     3480



acttaaagga ttgcaagggc cagatctgtt aagtggtttc ataggagaca catccagcaa     3540



ttgtgtggtc agtggctctt ttacccaata agatacatca cagtcacatg cttgatggtt     3600



tatgttgacc taagatttat tttgttaaaa tctctctctg ttgtgttcgt tcttgttctg     3660



ttttgttttg ttttttaaag tcttgctgtg gtctctttgt ggcagaagtg tttcatgcat     3720



ggcagcaggc ctgttgcttt tttatggcga ttcccattga aaatgtaagt aaatgtctgt     3780



ggccttgttc tctctatggt aaagatatta ttcaccatgt aaaacaaaaa acaatattta     3840



ttgtatttta gtatatttat ataattatgt tattgaaaaa aattggcatt aaaacttaac     3900



cgcatcagaa cctattgtaa atacaagttc tatttaagtg tactaattaa catataatat     3960



atgttttaaa tatagaattt ttaatgtttt taaatatatt ttcaaagtac ataaaa         4016





<210>  27

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  27



Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 

1               5                   10                  15      





Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 

            20                  25                  30          





Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 

        35                  40                  45              





Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 

    50                  55                  60                  





His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 

65                  70                  75                  80  





Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 

                85                  90                  95      





Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 

            100                 105                 110         





Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 

        115                 120                 125             





His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 

    130                 135                 140                 





Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 

145                 150                 155                 160 





Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 

                165                 170                 175     





Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 

            180                 185                 190         





Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 

        195                 200                 205             





Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 

    210                 215                 220                 





Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 

225                 230                 235                 240 





Leu Thr Ile Lys Arg Gly Arg 

                245         





<210>  28

<211>  4521

<212>  DNA

<213>  Homo sapiens



<400>  28

cacacacaca cacacacaca gagagaacat ctctagtaaa aagaaaagtt gagctttctt       60



agctagatgt gtgtattagc cagaaaaagc caaggagtga agggttttag agaactggag      120



gagataaagt ggagtctgca tatgggaggc atttgaaatg gacttaaatg tctttttaat      180



gctgactttt tcagttttct ccttaccaga cacattgttt tcatgacatt agccccaggc      240



atagacacat cattaaaatg aacatgtcaa aaaatgattt ctgtttagaa ataagcaaaa      300



cattttcagt tgtgaccacc caggtgtaga ataaagaaca gtggaattgg gagccctgag      360



ttctaacata aactttcttc atgacataag gcaagtcttc tatggccttt ggtttcctta      420



cctgtaaaac aggatggctc aatgaaatta tctttcttct ttgctataat agagtatctc      480



tgtgggaaga ggaaaaaaaa agtcaattta aaggctcctt atagttcccc aactgctgtt      540



ttattgtgct attcatgcct agacatcaca tagctagaaa ggcccatcag acccctcagg      600



ccactgctgt tcctgtcaca cattcctgca aaggaccatg ttgctaactt gaaaaaaatt      660



actattaatt acacttgcag ttgttgctta gtaacattta tgattttgtg tttctcgtga      720



cagcatgagc agagatcatt aaaaattaaa cttacaaagc tgctaaagtg ggaagaagga      780



gaacttgaag ccacaatttt tgcacttgct tagaagccat ctaatctcag ttccaccagg      840



tgagaagagt gatgaccatc cttttcctta ctatggttat ttcatacttt ggttgcatga      900



aggctgcccc catgaaagaa gcaaacatcc gaggacaagg tggcttggcc tacccaggtg      960



tgcggaccca tgggactctg gagagcgtga atgggcccaa ggcaggttca agaggcttga     1020



catcattggc tgacactttc gaacacgtga tagaagagct gttggatgag gaccagaaag     1080



ttcggcccaa tgaagaaaac aataaggacg cagacttgta cacgtccagg gtgatgctca     1140



gtagtcaagt gcctttggag cctcctcttc tctttctgct ggaggaatac aaaaattacc     1200



tagatgctgc aaacatgtcc atgagggtcc ggcgccactc tgaccctgcc cgccgagggg     1260



agctgagcgt gtgtgacagt attagtgagt gggtaacggc ggcagacaaa aagactgcag     1320



tggacatgtc gggcgggacg gtcacagtcc ttgaaaaggt ccctgtatca aaaggccaac     1380



tgaagcaata cttctacgag accaagtgca atcccatggg ttacacaaaa gaaggctgca     1440



ggggcataga caaaaggcat tggaactccc agtgccgaac tacccagtcg tacgtgcggg     1500



cccttaccat ggatagcaaa aagagaattg gctggcgatt cataaggata gacacttctt     1560



gtgtatgtac attgaccatt aaaaggggaa gatagtggat ttatgttgta tagattagat     1620



tatattgaga caaaaattat ctatttgtat atatacataa cagggtaaat tattcagtta     1680



agaaaaaaat aattttatga actgcatgta taaatgaagt ttatacagta cagtggttct     1740



acaatctatt tattggacat gtccatgacc agaagggaaa cagtcatttg cgcacaactt     1800



aaaaagtctg cattacattc cttgataatg ttgtggtttg ttgccgttgc caagaactga     1860



aaacataaaa agttaaaaaa aataataaat tgcatgctgc tttaattgtg aattgataat     1920



aaactgtcct ctttcagaaa acagaaaaaa acacacacac acacaacaaa aatttgaacc     1980



aaaacattcc gtttacattt tagacagtaa gtatcttcgt tcttgttagt actatatctg     2040



ttttactgct tttaacttct gatagcgttg gaattaaaac aatgtcaagg tgctgttgtc     2100



attgctttac tggcttaggg gatgggggat ggggggtata tttttgtttg ttttgtgttt     2160



ttttttcgtt tgtttgtttt gttttttagt tcccacaggg agtagagatg gggaaagaat     2220



tcctacaata tatattctgg ctgataaaag atacatttgt atgttgtgaa gatgtttgca     2280



atatcgatca gatgactaga aagtgaataa aaattaaggc aactgaacaa aaaaatgctc     2340



acactccaca tcccgtgatg cacctcccag gccccgctca ttctttgggc gttggtcaga     2400



gtaagctgct tttgacggaa ggacctatgt ttgctcagaa cacattcttt ccccccctcc     2460



ccctctggtc tcctctttgt tttgttttaa ggaagaaaaa tcagttgcgc gttctgaaat     2520



attttaccac tgctgtgaac aagtgaacac attgtgtcac atcatgacac tcgtataagc     2580



atggagaaca gtgatttttt tttagaacag aaaacaacaa aaaataaccc caaaatgaag     2640



attatttttt atgaggagtg aacatttggg taaatcatgg ctaagcttaa aaaaaactca     2700



tggtgaggct taacaatgtc ttgtaagcaa aaggtagagc cctgtatcaa cccagaaaca     2760



cctagatcag aacaggaatc cacattgcca gtgacatgag actgaacagc caaatggagg     2820



ctatgtggag ttggcattgc atttaccggc agtgcgggag gaatttctga gtggccatcc     2880



caaggtctag gtggaggtgg ggcatggtat ttgagacatt ccaaaacgaa ggcctctgaa     2940



ggacccttca gaggtggctc tggaatgaca tgtgtcaagc tgcttggacc tcgtgcttta     3000



agtgcctaca ttatctaact gtgctcaaga ggttctcgac tggaggacca cactcaagcc     3060



gacttatgcc caccatccca cctctggata attttgcata aaattggatt agcctggagc     3120



aggttgggag ccaaatgtgg catttgtgat catgagattg atgcaatgag atagaagatg     3180



tttgctacct gaacacttat tgctttgaaa ctagacttga ggaaaccagg gtttatcttt     3240



tgagaacttt tggtaaggga aaagggaaca ggaaaagaaa ccccaaactc aggccgaatg     3300



atcaagggga cccataggaa atcttgtcca gagacaagac ttcgggaagg tgtctggaca     3360



ttcagaacac caagacttga aggtgccttg ctcaatggaa gaggccagga cagagctgac     3420



aaaattttgc tccccagtga aggccacagc aaccttctgc ccatcctgtc tgttcatgga     3480



gagggtccct gcctcacctc tgccattttg ggttaggaga agtcaagttg ggagcctgaa     3540



atagtggttc ttggaaaaat ggatccccag tgaaaactag agctctaagc ccattcagcc     3600



catttcacac ctgaaaatgt tagtgatcac cacttggacc agcatcctta agtatcagaa     3660



agccccaagc aattgctgca tcttagtagg gtgagggata agcaaaagag gatgttcacc     3720



ataacccagg aatgaagata ccatcagcaa agaatttcaa tttgttcagt ctttcattta     3780



gagctagtct ttcacagtac catctgaata cctctttgaa agaaggaaga ctttacgtag     3840



tgtagatttg ttttgtgttg tttgaaaata ttatctttgt aattattttt aatatgtaag     3900



gaatgcttgg aatatctgct atatgtcaac tttatgcagc ttccttttga gggacaaatt     3960



taaaacaaac aaccccccat cacaaactta aaggattgca agggccagat ctgttaagtg     4020



gtttcatagg agacacatcc agcaattgtg tggtcagtgg ctcttttacc caataagata     4080



catcacagtc acatgcttga tggtttatgt tgacctaaga tttattttgt taaaatctct     4140



ctctgttgtg ttcgttcttg ttctgttttg ttttgttttt taaagtcttg ctgtggtctc     4200



tttgtggcag aagtgtttca tgcatggcag caggcctgtt gcttttttat ggcgattccc     4260



attgaaaatg taagtaaatg tctgtggcct tgttctctct atggtaaaga tattattcac     4320



catgtaaaac aaaaaacaat atttattgta ttttagtata tttatataat tatgttattg     4380



aaaaaaattg gcattaaaac ttaaccgcat cagaacctat tgtaaataca agttctattt     4440



aagtgtacta attaacatat aatatatgtt ttaaatatag aatttttaat gtttttaaat     4500



atattttcaa agtacataaa a                                               4521





<210>  29

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  29



Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 

1               5                   10                  15      





Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 

            20                  25                  30          





Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 

        35                  40                  45              





Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 

    50                  55                  60                  





His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 

65                  70                  75                  80  





Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 

                85                  90                  95      





Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 

            100                 105                 110         





Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 

        115                 120                 125             





His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 

    130                 135                 140                 





Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 

145                 150                 155                 160 





Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 

                165                 170                 175     





Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 

            180                 185                 190         





Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 

        195                 200                 205             





Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 

    210                 215                 220                 





Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 

225                 230                 235                 240 





Leu Thr Ile Lys Arg Gly Arg 

                245         





<210>  30

<211>  4123

<212>  DNA

<213>  Homo sapiens



<400>  30

agagctaaat aatgtctgac ccgggcgcaa ggcgcagcct ggagctccgg gtccccgccg       60



ctgccgccgc cgcgcccggg cgcacccgcc cgctcgctgt cccgcgcacc ccgtagcgcc      120



tcgggctccc gggccggaca gaggagccag cccggtgcgc ccctccacct cctgctcggg      180



gggctttaat gagacaccca ccgctgctgt ggggccggcg gggagcagca ccgcgacggg      240



gaccggggct gggcgctgga gccagaatcg gaaccacgat gtgactccgc cgccggggac      300



ccgtgaggtt tgtgtggacc ccgagcatga gcagagatca ttaaaaatta aacttacaaa      360



gctgctaaag tgggaagaag gagaacttga agccacaatt tttgcacttg cttagaagcc      420



atctaatctc agttccacca ggtgagaaga gtgatgacca tccttttcct tactatggtt      480



atttcatact ttggttgcat gaaggctgcc cccatgaaag aagcaaacat ccgaggacaa      540



ggtggcttgg cctacccagg tgtgcggacc catgggactc tggagagcgt gaatgggccc      600



aaggcaggtt caagaggctt gacatcattg gctgacactt tcgaacacgt gatagaagag      660



ctgttggatg aggaccagaa agttcggccc aatgaagaaa acaataagga cgcagacttg      720



tacacgtcca gggtgatgct cagtagtcaa gtgcctttgg agcctcctct tctctttctg      780



ctggaggaat acaaaaatta cctagatgct gcaaacatgt ccatgagggt ccggcgccac      840



tctgaccctg cccgccgagg ggagctgagc gtgtgtgaca gtattagtga gtgggtaacg      900



gcggcagaca aaaagactgc agtggacatg tcgggcggga cggtcacagt ccttgaaaag      960



gtccctgtat caaaaggcca actgaagcaa tacttctacg agaccaagtg caatcccatg     1020



ggttacacaa aagaaggctg caggggcata gacaaaaggc attggaactc ccagtgccga     1080



actacccagt cgtacgtgcg ggcccttacc atggatagca aaaagagaat tggctggcga     1140



ttcataagga tagacacttc ttgtgtatgt acattgacca ttaaaagggg aagatagtgg     1200



atttatgttg tatagattag attatattga gacaaaaatt atctatttgt atatatacat     1260



aacagggtaa attattcagt taagaaaaaa ataattttat gaactgcatg tataaatgaa     1320



gtttatacag tacagtggtt ctacaatcta tttattggac atgtccatga ccagaaggga     1380



aacagtcatt tgcgcacaac ttaaaaagtc tgcattacat tccttgataa tgttgtggtt     1440



tgttgccgtt gccaagaact gaaaacataa aaagttaaaa aaaataataa attgcatgct     1500



gctttaattg tgaattgata ataaactgtc ctctttcaga aaacagaaaa aaacacacac     1560



acacacaaca aaaatttgaa ccaaaacatt ccgtttacat tttagacagt aagtatcttc     1620



gttcttgtta gtactatatc tgttttactg cttttaactt ctgatagcgt tggaattaaa     1680



acaatgtcaa ggtgctgttg tcattgcttt actggcttag gggatggggg atggggggta     1740



tatttttgtt tgttttgtgt ttttttttcg tttgtttgtt ttgtttttta gttcccacag     1800



ggagtagaga tggggaaaga attcctacaa tatatattct ggctgataaa agatacattt     1860



gtatgttgtg aagatgtttg caatatcgat cagatgacta gaaagtgaat aaaaattaag     1920



gcaactgaac aaaaaaatgc tcacactcca catcccgtga tgcacctccc aggccccgct     1980



cattctttgg gcgttggtca gagtaagctg cttttgacgg aaggacctat gtttgctcag     2040



aacacattct ttccccccct ccccctctgg tctcctcttt gttttgtttt aaggaagaaa     2100



aatcagttgc gcgttctgaa atattttacc actgctgtga acaagtgaac acattgtgtc     2160



acatcatgac actcgtataa gcatggagaa cagtgatttt tttttagaac agaaaacaac     2220



aaaaaataac cccaaaatga agattatttt ttatgaggag tgaacatttg ggtaaatcat     2280



ggctaagctt aaaaaaaact catggtgagg cttaacaatg tcttgtaagc aaaaggtaga     2340



gccctgtatc aacccagaaa cacctagatc agaacaggaa tccacattgc cagtgacatg     2400



agactgaaca gccaaatgga ggctatgtgg agttggcatt gcatttaccg gcagtgcggg     2460



aggaatttct gagtggccat cccaaggtct aggtggaggt ggggcatggt atttgagaca     2520



ttccaaaacg aaggcctctg aaggaccctt cagaggtggc tctggaatga catgtgtcaa     2580



gctgcttgga cctcgtgctt taagtgccta cattatctaa ctgtgctcaa gaggttctcg     2640



actggaggac cacactcaag ccgacttatg cccaccatcc cacctctgga taattttgca     2700



taaaattgga ttagcctgga gcaggttggg agccaaatgt ggcatttgtg atcatgagat     2760



tgatgcaatg agatagaaga tgtttgctac ctgaacactt attgctttga aactagactt     2820



gaggaaacca gggtttatct tttgagaact tttggtaagg gaaaagggaa caggaaaaga     2880



aaccccaaac tcaggccgaa tgatcaaggg gacccatagg aaatcttgtc cagagacaag     2940



acttcgggaa ggtgtctgga cattcagaac accaagactt gaaggtgcct tgctcaatgg     3000



aagaggccag gacagagctg acaaaatttt gctccccagt gaaggccaca gcaaccttct     3060



gcccatcctg tctgttcatg gagagggtcc ctgcctcacc tctgccattt tgggttagga     3120



gaagtcaagt tgggagcctg aaatagtggt tcttggaaaa atggatcccc agtgaaaact     3180



agagctctaa gcccattcag cccatttcac acctgaaaat gttagtgatc accacttgga     3240



ccagcatcct taagtatcag aaagccccaa gcaattgctg catcttagta gggtgaggga     3300



taagcaaaag aggatgttca ccataaccca ggaatgaaga taccatcagc aaagaatttc     3360



aatttgttca gtctttcatt tagagctagt ctttcacagt accatctgaa tacctctttg     3420



aaagaaggaa gactttacgt agtgtagatt tgttttgtgt tgtttgaaaa tattatcttt     3480



gtaattattt ttaatatgta aggaatgctt ggaatatctg ctatatgtca actttatgca     3540



gcttcctttt gagggacaaa tttaaaacaa acaacccccc atcacaaact taaaggattg     3600



caagggccag atctgttaag tggtttcata ggagacacat ccagcaattg tgtggtcagt     3660



ggctctttta cccaataaga tacatcacag tcacatgctt gatggtttat gttgacctaa     3720



gatttatttt gttaaaatct ctctctgttg tgttcgttct tgttctgttt tgttttgttt     3780



tttaaagtct tgctgtggtc tctttgtggc agaagtgttt catgcatggc agcaggcctg     3840



ttgctttttt atggcgattc ccattgaaaa tgtaagtaaa tgtctgtggc cttgttctct     3900



ctatggtaaa gatattattc accatgtaaa acaaaaaaca atatttattg tattttagta     3960



tatttatata attatgttat tgaaaaaaat tggcattaaa acttaaccgc atcagaacct     4020



attgtaaata caagttctat ttaagtgtac taattaacat ataatatatg ttttaaatat     4080



agaattttta atgtttttaa atatattttc aaagtacata aaa                       4123





<210>  31

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  31



Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 

1               5                   10                  15      





Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 

            20                  25                  30          





Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 

        35                  40                  45              





Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 

    50                  55                  60                  





His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 

65                  70                  75                  80  





Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 

                85                  90                  95      





Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 

            100                 105                 110         





Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 

        115                 120                 125             





His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 

    130                 135                 140                 





Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 

145                 150                 155                 160 





Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 

                165                 170                 175     





Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 

            180                 185                 190         





Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 

        195                 200                 205             





Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 

    210                 215                 220                 





Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 

225                 230                 235                 240 





Leu Thr Ile Lys Arg Gly Arg 

                245         





<210>  32

<211>  3998

<212>  DNA

<213>  Homo sapiens



<400>  32

agagctaaat aatgtctgac ccgggcgcaa ggcgcagcct ggagctccgg gtccccgccg       60



ctgccgccgc cgcgcccggg cgcacccgcc cgctcgctgt cccgcgcacc ccgtagcgcc      120



tcgggctccc gggccggaca gaggagccag cccggtgcgc ccctccacct cctgctcggg      180



gggctttaat gagacaccca ccgctgctgt ggggccggcg gggagcagca ccgcgacggg      240



gaccggggct gggcgctgga gccagaatcg gaaccacgat gtgactccgc cgccggggac      300



ccgtgagttc caccaggtga gaagagtgat gaccatcctt ttccttacta tggttatttc      360



atactttggt tgcatgaagg ctgcccccat gaaagaagca aacatccgag gacaaggtgg      420



cttggcctac ccaggtgtgc ggacccatgg gactctggag agcgtgaatg ggcccaaggc      480



aggttcaaga ggcttgacat cattggctga cactttcgaa cacgtgatag aagagctgtt      540



ggatgaggac cagaaagttc ggcccaatga agaaaacaat aaggacgcag acttgtacac      600



gtccagggtg atgctcagta gtcaagtgcc tttggagcct cctcttctct ttctgctgga      660



ggaatacaaa aattacctag atgctgcaaa catgtccatg agggtccggc gccactctga      720



ccctgcccgc cgaggggagc tgagcgtgtg tgacagtatt agtgagtggg taacggcggc      780



agacaaaaag actgcagtgg acatgtcggg cgggacggtc acagtccttg aaaaggtccc      840



tgtatcaaaa ggccaactga agcaatactt ctacgagacc aagtgcaatc ccatgggtta      900



cacaaaagaa ggctgcaggg gcatagacaa aaggcattgg aactcccagt gccgaactac      960



ccagtcgtac gtgcgggccc ttaccatgga tagcaaaaag agaattggct ggcgattcat     1020



aaggatagac acttcttgtg tatgtacatt gaccattaaa aggggaagat agtggattta     1080



tgttgtatag attagattat attgagacaa aaattatcta tttgtatata tacataacag     1140



ggtaaattat tcagttaaga aaaaaataat tttatgaact gcatgtataa atgaagttta     1200



tacagtacag tggttctaca atctatttat tggacatgtc catgaccaga agggaaacag     1260



tcatttgcgc acaacttaaa aagtctgcat tacattcctt gataatgttg tggtttgttg     1320



ccgttgccaa gaactgaaaa cataaaaagt taaaaaaaat aataaattgc atgctgcttt     1380



aattgtgaat tgataataaa ctgtcctctt tcagaaaaca gaaaaaaaca cacacacaca     1440



caacaaaaat ttgaaccaaa acattccgtt tacattttag acagtaagta tcttcgttct     1500



tgttagtact atatctgttt tactgctttt aacttctgat agcgttggaa ttaaaacaat     1560



gtcaaggtgc tgttgtcatt gctttactgg cttaggggat gggggatggg gggtatattt     1620



ttgtttgttt tgtgtttttt tttcgtttgt ttgttttgtt ttttagttcc cacagggagt     1680



agagatgggg aaagaattcc tacaatatat attctggctg ataaaagata catttgtatg     1740



ttgtgaagat gtttgcaata tcgatcagat gactagaaag tgaataaaaa ttaaggcaac     1800



tgaacaaaaa aatgctcaca ctccacatcc cgtgatgcac ctcccaggcc ccgctcattc     1860



tttgggcgtt ggtcagagta agctgctttt gacggaagga cctatgtttg ctcagaacac     1920



attctttccc cccctccccc tctggtctcc tctttgtttt gttttaagga agaaaaatca     1980



gttgcgcgtt ctgaaatatt ttaccactgc tgtgaacaag tgaacacatt gtgtcacatc     2040



atgacactcg tataagcatg gagaacagtg attttttttt agaacagaaa acaacaaaaa     2100



ataaccccaa aatgaagatt attttttatg aggagtgaac atttgggtaa atcatggcta     2160



agcttaaaaa aaactcatgg tgaggcttaa caatgtcttg taagcaaaag gtagagccct     2220



gtatcaaccc agaaacacct agatcagaac aggaatccac attgccagtg acatgagact     2280



gaacagccaa atggaggcta tgtggagttg gcattgcatt taccggcagt gcgggaggaa     2340



tttctgagtg gccatcccaa ggtctaggtg gaggtggggc atggtatttg agacattcca     2400



aaacgaaggc ctctgaagga cccttcagag gtggctctgg aatgacatgt gtcaagctgc     2460



ttggacctcg tgctttaagt gcctacatta tctaactgtg ctcaagaggt tctcgactgg     2520



aggaccacac tcaagccgac ttatgcccac catcccacct ctggataatt ttgcataaaa     2580



ttggattagc ctggagcagg ttgggagcca aatgtggcat ttgtgatcat gagattgatg     2640



caatgagata gaagatgttt gctacctgaa cacttattgc tttgaaacta gacttgagga     2700



aaccagggtt tatcttttga gaacttttgg taagggaaaa gggaacagga aaagaaaccc     2760



caaactcagg ccgaatgatc aaggggaccc ataggaaatc ttgtccagag acaagacttc     2820



gggaaggtgt ctggacattc agaacaccaa gacttgaagg tgccttgctc aatggaagag     2880



gccaggacag agctgacaaa attttgctcc ccagtgaagg ccacagcaac cttctgccca     2940



tcctgtctgt tcatggagag ggtccctgcc tcacctctgc cattttgggt taggagaagt     3000



caagttggga gcctgaaata gtggttcttg gaaaaatgga tccccagtga aaactagagc     3060



tctaagccca ttcagcccat ttcacacctg aaaatgttag tgatcaccac ttggaccagc     3120



atccttaagt atcagaaagc cccaagcaat tgctgcatct tagtagggtg agggataagc     3180



aaaagaggat gttcaccata acccaggaat gaagatacca tcagcaaaga atttcaattt     3240



gttcagtctt tcatttagag ctagtctttc acagtaccat ctgaatacct ctttgaaaga     3300



aggaagactt tacgtagtgt agatttgttt tgtgttgttt gaaaatatta tctttgtaat     3360



tatttttaat atgtaaggaa tgcttggaat atctgctata tgtcaacttt atgcagcttc     3420



cttttgaggg acaaatttaa aacaaacaac cccccatcac aaacttaaag gattgcaagg     3480



gccagatctg ttaagtggtt tcataggaga cacatccagc aattgtgtgg tcagtggctc     3540



ttttacccaa taagatacat cacagtcaca tgcttgatgg tttatgttga cctaagattt     3600



attttgttaa aatctctctc tgttgtgttc gttcttgttc tgttttgttt tgttttttaa     3660



agtcttgctg tggtctcttt gtggcagaag tgtttcatgc atggcagcag gcctgttgct     3720



tttttatggc gattcccatt gaaaatgtaa gtaaatgtct gtggccttgt tctctctatg     3780



gtaaagatat tattcaccat gtaaaacaaa aaacaatatt tattgtattt tagtatattt     3840



atataattat gttattgaaa aaaattggca ttaaaactta accgcatcag aacctattgt     3900



aaatacaagt tctatttaag tgtactaatt aacatataat atatgtttta aatatagaat     3960



ttttaatgtt tttaaatata ttttcaaagt acataaaa                             3998





<210>  33

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  33



Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 

1               5                   10                  15      





Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 

            20                  25                  30          





Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 

        35                  40                  45              





Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 

    50                  55                  60                  





His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 

65                  70                  75                  80  





Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 

                85                  90                  95      





Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 

            100                 105                 110         





Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 

        115                 120                 125             





His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 

    130                 135                 140                 





Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 

145                 150                 155                 160 





Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 

                165                 170                 175     





Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 

            180                 185                 190         





Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 

        195                 200                 205             





Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 

    210                 215                 220                 





Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 

225                 230                 235                 240 





Leu Thr Ile Lys Arg Gly Arg 

                245         





<210>  34

<211>  3916

<212>  DNA

<213>  Homo sapiens



<400>  34

agagttgaaa gctaggggag cgagacctcg gggcgtgcga ttctcactcg ctccctcccg       60



ccccagcgcc cacagccggg gtttctgcag agggcgcggg acgcggggtt ccccggggct      120



gaggctgggg ctggaacacc cctcgaagcc gcgggcgtcc tgtccaaggc gccccaggag      180



ggcgcaggac tcgcagggcg atgtcgcggg gccctagggg aggagttcca ccaggtgaga      240



agagtgatga ccatcctttt ccttactatg gttatttcat actttggttg catgaaggct      300



gcccccatga aagaagcaaa catccgagga caaggtggct tggcctaccc aggtgtgcgg      360



acccatggga ctctggagag cgtgaatggg cccaaggcag gttcaagagg cttgacatca      420



ttggctgaca ctttcgaaca cgtgatagaa gagctgttgg atgaggacca gaaagttcgg      480



cccaatgaag aaaacaataa ggacgcagac ttgtacacgt ccagggtgat gctcagtagt      540



caagtgcctt tggagcctcc tcttctcttt ctgctggagg aatacaaaaa ttacctagat      600



gctgcaaaca tgtccatgag ggtccggcgc cactctgacc ctgcccgccg aggggagctg      660



agcgtgtgtg acagtattag tgagtgggta acggcggcag acaaaaagac tgcagtggac      720



atgtcgggcg ggacggtcac agtccttgaa aaggtccctg tatcaaaagg ccaactgaag      780



caatacttct acgagaccaa gtgcaatccc atgggttaca caaaagaagg ctgcaggggc      840



atagacaaaa ggcattggaa ctcccagtgc cgaactaccc agtcgtacgt gcgggccctt      900



accatggata gcaaaaagag aattggctgg cgattcataa ggatagacac ttcttgtgta      960



tgtacattga ccattaaaag gggaagatag tggatttatg ttgtatagat tagattatat     1020



tgagacaaaa attatctatt tgtatatata cataacaggg taaattattc agttaagaaa     1080



aaaataattt tatgaactgc atgtataaat gaagtttata cagtacagtg gttctacaat     1140



ctatttattg gacatgtcca tgaccagaag ggaaacagtc atttgcgcac aacttaaaaa     1200



gtctgcatta cattccttga taatgttgtg gtttgttgcc gttgccaaga actgaaaaca     1260



taaaaagtta aaaaaaataa taaattgcat gctgctttaa ttgtgaattg ataataaact     1320



gtcctctttc agaaaacaga aaaaaacaca cacacacaca acaaaaattt gaaccaaaac     1380



attccgttta cattttagac agtaagtatc ttcgttcttg ttagtactat atctgtttta     1440



ctgcttttaa cttctgatag cgttggaatt aaaacaatgt caaggtgctg ttgtcattgc     1500



tttactggct taggggatgg gggatggggg gtatattttt gtttgttttg tgtttttttt     1560



tcgtttgttt gttttgtttt ttagttccca cagggagtag agatggggaa agaattccta     1620



caatatatat tctggctgat aaaagataca tttgtatgtt gtgaagatgt ttgcaatatc     1680



gatcagatga ctagaaagtg aataaaaatt aaggcaactg aacaaaaaaa tgctcacact     1740



ccacatcccg tgatgcacct cccaggcccc gctcattctt tgggcgttgg tcagagtaag     1800



ctgcttttga cggaaggacc tatgtttgct cagaacacat tctttccccc cctccccctc     1860



tggtctcctc tttgttttgt tttaaggaag aaaaatcagt tgcgcgttct gaaatatttt     1920



accactgctg tgaacaagtg aacacattgt gtcacatcat gacactcgta taagcatgga     1980



gaacagtgat ttttttttag aacagaaaac aacaaaaaat aaccccaaaa tgaagattat     2040



tttttatgag gagtgaacat ttgggtaaat catggctaag cttaaaaaaa actcatggtg     2100



aggcttaaca atgtcttgta agcaaaaggt agagccctgt atcaacccag aaacacctag     2160



atcagaacag gaatccacat tgccagtgac atgagactga acagccaaat ggaggctatg     2220



tggagttggc attgcattta ccggcagtgc gggaggaatt tctgagtggc catcccaagg     2280



tctaggtgga ggtggggcat ggtatttgag acattccaaa acgaaggcct ctgaaggacc     2340



cttcagaggt ggctctggaa tgacatgtgt caagctgctt ggacctcgtg ctttaagtgc     2400



ctacattatc taactgtgct caagaggttc tcgactggag gaccacactc aagccgactt     2460



atgcccacca tcccacctct ggataatttt gcataaaatt ggattagcct ggagcaggtt     2520



gggagccaaa tgtggcattt gtgatcatga gattgatgca atgagataga agatgtttgc     2580



tacctgaaca cttattgctt tgaaactaga cttgaggaaa ccagggttta tcttttgaga     2640



acttttggta agggaaaagg gaacaggaaa agaaacccca aactcaggcc gaatgatcaa     2700



ggggacccat aggaaatctt gtccagagac aagacttcgg gaaggtgtct ggacattcag     2760



aacaccaaga cttgaaggtg ccttgctcaa tggaagaggc caggacagag ctgacaaaat     2820



tttgctcccc agtgaaggcc acagcaacct tctgcccatc ctgtctgttc atggagaggg     2880



tccctgcctc acctctgcca ttttgggtta ggagaagtca agttgggagc ctgaaatagt     2940



ggttcttgga aaaatggatc cccagtgaaa actagagctc taagcccatt cagcccattt     3000



cacacctgaa aatgttagtg atcaccactt ggaccagcat ccttaagtat cagaaagccc     3060



caagcaattg ctgcatctta gtagggtgag ggataagcaa aagaggatgt tcaccataac     3120



ccaggaatga agataccatc agcaaagaat ttcaatttgt tcagtctttc atttagagct     3180



agtctttcac agtaccatct gaatacctct ttgaaagaag gaagacttta cgtagtgtag     3240



atttgttttg tgttgtttga aaatattatc tttgtaatta tttttaatat gtaaggaatg     3300



cttggaatat ctgctatatg tcaactttat gcagcttcct tttgagggac aaatttaaaa     3360



caaacaaccc cccatcacaa acttaaagga ttgcaagggc cagatctgtt aagtggtttc     3420



ataggagaca catccagcaa ttgtgtggtc agtggctctt ttacccaata agatacatca     3480



cagtcacatg cttgatggtt tatgttgacc taagatttat tttgttaaaa tctctctctg     3540



ttgtgttcgt tcttgttctg ttttgttttg ttttttaaag tcttgctgtg gtctctttgt     3600



ggcagaagtg tttcatgcat ggcagcaggc ctgttgcttt tttatggcga ttcccattga     3660



aaatgtaagt aaatgtctgt ggccttgttc tctctatggt aaagatatta ttcaccatgt     3720



aaaacaaaaa acaatattta ttgtatttta gtatatttat ataattatgt tattgaaaaa     3780



aattggcatt aaaacttaac cgcatcagaa cctattgtaa atacaagttc tatttaagtg     3840



tactaattaa catataatat atgttttaaa tatagaattt ttaatgtttt taaatatatt     3900



ttcaaagtac ataaaa                                                     3916





<210>  35

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  35



Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 

1               5                   10                  15      





Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 

            20                  25                  30          





Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 

        35                  40                  45              





Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 

    50                  55                  60                  





His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 

65                  70                  75                  80  





Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 

                85                  90                  95      





Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 

            100                 105                 110         





Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 

        115                 120                 125             





His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 

    130                 135                 140                 





Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 

145                 150                 155                 160 





Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 

                165                 170                 175     





Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 

            180                 185                 190         





Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 

        195                 200                 205             





Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 

    210                 215                 220                 





Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 

225                 230                 235                 240 





Leu Thr Ile Lys Arg Gly Arg 

                245         





<210>  36

<211>  4174

<212>  DNA

<213>  Homo sapiens



<400>  36

gtaaaccaat agcccccatg ctctgtgcga tttcattgtg tgctcgcgtt cgcaagctcc       60



gtagtgcagg aaggtgcggg aagttaagta attaaaagaa attatagagt gggatgcaaa      120



aataacccga aggacaactg gatgtgtgga gccaccagtt ttctccatga gtgcacaagg      180



ttaatccttg ttactactca gaatgctgag tttctacaga aagggttgca ggtccacaca      240



tgttttggcg tctacccaca cgcttctgta tggcatgact gtgcatccca gaagaagggc      300



tgtgctgtgt acctccacgt ttcagtggaa tttaacaaac tgatccctga aaatggtttc      360



ataaagggat ggtaataaag tctcttagtg gttgaaaatg ttatttctta caaaagtgga      420



gaacatttgc ttttcaatac cagagttttc agccatttct gcattctgac ctattgactg      480



gagttccacc aggtgagaag agtgatgacc atccttttcc ttactatggt tatttcatac      540



tttggttgca tgaaggctgc ccccatgaaa gaagcaaaca tccgaggaca aggtggcttg      600



gcctacccag gtgtgcggac ccatgggact ctggagagcg tgaatgggcc caaggcaggt      660



tcaagaggct tgacatcatt ggctgacact ttcgaacacg tgatagaaga gctgttggat      720



gaggaccaga aagttcggcc caatgaagaa aacaataagg acgcagactt gtacacgtcc      780



agggtgatgc tcagtagtca agtgcctttg gagcctcctc ttctctttct gctggaggaa      840



tacaaaaatt acctagatgc tgcaaacatg tccatgaggg tccggcgcca ctctgaccct      900



gcccgccgag gggagctgag cgtgtgtgac agtattagtg agtgggtaac ggcggcagac      960



aaaaagactg cagtggacat gtcgggcggg acggtcacag tccttgaaaa ggtccctgta     1020



tcaaaaggcc aactgaagca atacttctac gagaccaagt gcaatcccat gggttacaca     1080



aaagaaggct gcaggggcat agacaaaagg cattggaact cccagtgccg aactacccag     1140



tcgtacgtgc gggcccttac catggatagc aaaaagagaa ttggctggcg attcataagg     1200



atagacactt cttgtgtatg tacattgacc attaaaaggg gaagatagtg gatttatgtt     1260



gtatagatta gattatattg agacaaaaat tatctatttg tatatataca taacagggta     1320



aattattcag ttaagaaaaa aataatttta tgaactgcat gtataaatga agtttataca     1380



gtacagtggt tctacaatct atttattgga catgtccatg accagaaggg aaacagtcat     1440



ttgcgcacaa cttaaaaagt ctgcattaca ttccttgata atgttgtggt ttgttgccgt     1500



tgccaagaac tgaaaacata aaaagttaaa aaaaataata aattgcatgc tgctttaatt     1560



gtgaattgat aataaactgt cctctttcag aaaacagaaa aaaacacaca cacacacaac     1620



aaaaatttga accaaaacat tccgtttaca ttttagacag taagtatctt cgttcttgtt     1680



agtactatat ctgttttact gcttttaact tctgatagcg ttggaattaa aacaatgtca     1740



aggtgctgtt gtcattgctt tactggctta ggggatgggg gatggggggt atatttttgt     1800



ttgttttgtg tttttttttc gtttgtttgt tttgtttttt agttcccaca gggagtagag     1860



atggggaaag aattcctaca atatatattc tggctgataa aagatacatt tgtatgttgt     1920



gaagatgttt gcaatatcga tcagatgact agaaagtgaa taaaaattaa ggcaactgaa     1980



caaaaaaatg ctcacactcc acatcccgtg atgcacctcc caggccccgc tcattctttg     2040



ggcgttggtc agagtaagct gcttttgacg gaaggaccta tgtttgctca gaacacattc     2100



tttccccccc tccccctctg gtctcctctt tgttttgttt taaggaagaa aaatcagttg     2160



cgcgttctga aatattttac cactgctgtg aacaagtgaa cacattgtgt cacatcatga     2220



cactcgtata agcatggaga acagtgattt ttttttagaa cagaaaacaa caaaaaataa     2280



ccccaaaatg aagattattt tttatgagga gtgaacattt gggtaaatca tggctaagct     2340



taaaaaaaac tcatggtgag gcttaacaat gtcttgtaag caaaaggtag agccctgtat     2400



caacccagaa acacctagat cagaacagga atccacattg ccagtgacat gagactgaac     2460



agccaaatgg aggctatgtg gagttggcat tgcatttacc ggcagtgcgg gaggaatttc     2520



tgagtggcca tcccaaggtc taggtggagg tggggcatgg tatttgagac attccaaaac     2580



gaaggcctct gaaggaccct tcagaggtgg ctctggaatg acatgtgtca agctgcttgg     2640



acctcgtgct ttaagtgcct acattatcta actgtgctca agaggttctc gactggagga     2700



ccacactcaa gccgacttat gcccaccatc ccacctctgg ataattttgc ataaaattgg     2760



attagcctgg agcaggttgg gagccaaatg tggcatttgt gatcatgaga ttgatgcaat     2820



gagatagaag atgtttgcta cctgaacact tattgctttg aaactagact tgaggaaacc     2880



agggtttatc ttttgagaac ttttggtaag ggaaaaggga acaggaaaag aaaccccaaa     2940



ctcaggccga atgatcaagg ggacccatag gaaatcttgt ccagagacaa gacttcggga     3000



aggtgtctgg acattcagaa caccaagact tgaaggtgcc ttgctcaatg gaagaggcca     3060



ggacagagct gacaaaattt tgctccccag tgaaggccac agcaaccttc tgcccatcct     3120



gtctgttcat ggagagggtc cctgcctcac ctctgccatt ttgggttagg agaagtcaag     3180



ttgggagcct gaaatagtgg ttcttggaaa aatggatccc cagtgaaaac tagagctcta     3240



agcccattca gcccatttca cacctgaaaa tgttagtgat caccacttgg accagcatcc     3300



ttaagtatca gaaagcccca agcaattgct gcatcttagt agggtgaggg ataagcaaaa     3360



gaggatgttc accataaccc aggaatgaag ataccatcag caaagaattt caatttgttc     3420



agtctttcat ttagagctag tctttcacag taccatctga atacctcttt gaaagaagga     3480



agactttacg tagtgtagat ttgttttgtg ttgtttgaaa atattatctt tgtaattatt     3540



tttaatatgt aaggaatgct tggaatatct gctatatgtc aactttatgc agcttccttt     3600



tgagggacaa atttaaaaca aacaaccccc catcacaaac ttaaaggatt gcaagggcca     3660



gatctgttaa gtggtttcat aggagacaca tccagcaatt gtgtggtcag tggctctttt     3720



acccaataag atacatcaca gtcacatgct tgatggttta tgttgaccta agatttattt     3780



tgttaaaatc tctctctgtt gtgttcgttc ttgttctgtt ttgttttgtt ttttaaagtc     3840



ttgctgtggt ctctttgtgg cagaagtgtt tcatgcatgg cagcaggcct gttgcttttt     3900



tatggcgatt cccattgaaa atgtaagtaa atgtctgtgg ccttgttctc tctatggtaa     3960



agatattatt caccatgtaa aacaaaaaac aatatttatt gtattttagt atatttatat     4020



aattatgtta ttgaaaaaaa ttggcattaa aacttaaccg catcagaacc tattgtaaat     4080



acaagttcta tttaagtgta ctaattaaca tataatatat gttttaaata tagaattttt     4140



aatgttttta aatatatttt caaagtacat aaaa                                 4174





<210>  37

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  37



Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 

1               5                   10                  15      





Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 

            20                  25                  30          





Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 

        35                  40                  45              





Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 

    50                  55                  60                  





His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 

65                  70                  75                  80  





Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 

                85                  90                  95      





Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 

            100                 105                 110         





Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 

        115                 120                 125             





His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 

    130                 135                 140                 





Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 

145                 150                 155                 160 





Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 

                165                 170                 175     





Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 

            180                 185                 190         





Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 

        195                 200                 205             





Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 

    210                 215                 220                 





Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 

225                 230                 235                 240 





Leu Thr Ile Lys Arg Gly Arg 

                245         





<210>  38

<211>  4057

<212>  DNA

<213>  Homo sapiens



<400>  38

gtaaaccaat agcccccatg ctctgtgcga tttcattgtg tgctcgcgtt cgcaagctcc       60



gtagtgcagg aaggtgcggg aagttaagta attaaaagaa attatagagt gggatgcaaa      120



aataacccga aggacaactg gatgtgtgga gccaccagtt ttctccatga gtgcacaagg      180



ttaatccttg ttactactca gaatgctgag tttctacaga aagggttgca ggtccacaca      240



tgttttggcg tctacccaca cgcttctgta tggcatgact gtgcatccca gaagaagggc      300



tgtgctgtgt acctccacgt ttcagtggaa tttaacaaac tgatccctga aaatggtttc      360



ataaagttcc accaggtgag aagagtgatg accatccttt tccttactat ggttatttca      420



tactttggtt gcatgaaggc tgcccccatg aaagaagcaa acatccgagg acaaggtggc      480



ttggcctacc caggtgtgcg gacccatggg actctggaga gcgtgaatgg gcccaaggca      540



ggttcaagag gcttgacatc attggctgac actttcgaac acgtgataga agagctgttg      600



gatgaggacc agaaagttcg gcccaatgaa gaaaacaata aggacgcaga cttgtacacg      660



tccagggtga tgctcagtag tcaagtgcct ttggagcctc ctcttctctt tctgctggag      720



gaatacaaaa attacctaga tgctgcaaac atgtccatga gggtccggcg ccactctgac      780



cctgcccgcc gaggggagct gagcgtgtgt gacagtatta gtgagtgggt aacggcggca      840



gacaaaaaga ctgcagtgga catgtcgggc gggacggtca cagtccttga aaaggtccct      900



gtatcaaaag gccaactgaa gcaatacttc tacgagacca agtgcaatcc catgggttac      960



acaaaagaag gctgcagggg catagacaaa aggcattgga actcccagtg ccgaactacc     1020



cagtcgtacg tgcgggccct taccatggat agcaaaaaga gaattggctg gcgattcata     1080



aggatagaca cttcttgtgt atgtacattg accattaaaa ggggaagata gtggatttat     1140



gttgtataga ttagattata ttgagacaaa aattatctat ttgtatatat acataacagg     1200



gtaaattatt cagttaagaa aaaaataatt ttatgaactg catgtataaa tgaagtttat     1260



acagtacagt ggttctacaa tctatttatt ggacatgtcc atgaccagaa gggaaacagt     1320



catttgcgca caacttaaaa agtctgcatt acattccttg ataatgttgt ggtttgttgc     1380



cgttgccaag aactgaaaac ataaaaagtt aaaaaaaata ataaattgca tgctgcttta     1440



attgtgaatt gataataaac tgtcctcttt cagaaaacag aaaaaaacac acacacacac     1500



aacaaaaatt tgaaccaaaa cattccgttt acattttaga cagtaagtat cttcgttctt     1560



gttagtacta tatctgtttt actgctttta acttctgata gcgttggaat taaaacaatg     1620



tcaaggtgct gttgtcattg ctttactggc ttaggggatg ggggatgggg ggtatatttt     1680



tgtttgtttt gtgttttttt ttcgtttgtt tgttttgttt tttagttccc acagggagta     1740



gagatgggga aagaattcct acaatatata ttctggctga taaaagatac atttgtatgt     1800



tgtgaagatg tttgcaatat cgatcagatg actagaaagt gaataaaaat taaggcaact     1860



gaacaaaaaa atgctcacac tccacatccc gtgatgcacc tcccaggccc cgctcattct     1920



ttgggcgttg gtcagagtaa gctgcttttg acggaaggac ctatgtttgc tcagaacaca     1980



ttctttcccc ccctccccct ctggtctcct ctttgttttg ttttaaggaa gaaaaatcag     2040



ttgcgcgttc tgaaatattt taccactgct gtgaacaagt gaacacattg tgtcacatca     2100



tgacactcgt ataagcatgg agaacagtga ttttttttta gaacagaaaa caacaaaaaa     2160



taaccccaaa atgaagatta ttttttatga ggagtgaaca tttgggtaaa tcatggctaa     2220



gcttaaaaaa aactcatggt gaggcttaac aatgtcttgt aagcaaaagg tagagccctg     2280



tatcaaccca gaaacaccta gatcagaaca ggaatccaca ttgccagtga catgagactg     2340



aacagccaaa tggaggctat gtggagttgg cattgcattt accggcagtg cgggaggaat     2400



ttctgagtgg ccatcccaag gtctaggtgg aggtggggca tggtatttga gacattccaa     2460



aacgaaggcc tctgaaggac ccttcagagg tggctctgga atgacatgtg tcaagctgct     2520



tggacctcgt gctttaagtg cctacattat ctaactgtgc tcaagaggtt ctcgactgga     2580



ggaccacact caagccgact tatgcccacc atcccacctc tggataattt tgcataaaat     2640



tggattagcc tggagcaggt tgggagccaa atgtggcatt tgtgatcatg agattgatgc     2700



aatgagatag aagatgtttg ctacctgaac acttattgct ttgaaactag acttgaggaa     2760



accagggttt atcttttgag aacttttggt aagggaaaag ggaacaggaa aagaaacccc     2820



aaactcaggc cgaatgatca aggggaccca taggaaatct tgtccagaga caagacttcg     2880



ggaaggtgtc tggacattca gaacaccaag acttgaaggt gccttgctca atggaagagg     2940



ccaggacaga gctgacaaaa ttttgctccc cagtgaaggc cacagcaacc ttctgcccat     3000



cctgtctgtt catggagagg gtccctgcct cacctctgcc attttgggtt aggagaagtc     3060



aagttgggag cctgaaatag tggttcttgg aaaaatggat ccccagtgaa aactagagct     3120



ctaagcccat tcagcccatt tcacacctga aaatgttagt gatcaccact tggaccagca     3180



tccttaagta tcagaaagcc ccaagcaatt gctgcatctt agtagggtga gggataagca     3240



aaagaggatg ttcaccataa cccaggaatg aagataccat cagcaaagaa tttcaatttg     3300



ttcagtcttt catttagagc tagtctttca cagtaccatc tgaatacctc tttgaaagaa     3360



ggaagacttt acgtagtgta gatttgtttt gtgttgtttg aaaatattat ctttgtaatt     3420



atttttaata tgtaaggaat gcttggaata tctgctatat gtcaacttta tgcagcttcc     3480



ttttgaggga caaatttaaa acaaacaacc ccccatcaca aacttaaagg attgcaaggg     3540



ccagatctgt taagtggttt cataggagac acatccagca attgtgtggt cagtggctct     3600



tttacccaat aagatacatc acagtcacat gcttgatggt ttatgttgac ctaagattta     3660



ttttgttaaa atctctctct gttgtgttcg ttcttgttct gttttgtttt gttttttaaa     3720



gtcttgctgt ggtctctttg tggcagaagt gtttcatgca tggcagcagg cctgttgctt     3780



ttttatggcg attcccattg aaaatgtaag taaatgtctg tggccttgtt ctctctatgg     3840



taaagatatt attcaccatg taaaacaaaa aacaatattt attgtatttt agtatattta     3900



tataattatg ttattgaaaa aaattggcat taaaacttaa ccgcatcaga acctattgta     3960



aatacaagtt ctatttaagt gtactaatta acatataata tatgttttaa atatagaatt     4020



tttaatgttt ttaaatatat tttcaaagta cataaaa                              4057





<210>  39

<211>  329

<212>  PRT

<213>  Homo sapiens



<400>  39



Met Cys Gly Ala Thr Ser Phe Leu His Glu Cys Thr Arg Leu Ile Leu 

1               5                   10                  15      





Val Thr Thr Gln Asn Ala Glu Phe Leu Gln Lys Gly Leu Gln Val His 

            20                  25                  30          





Thr Cys Phe Gly Val Tyr Pro His Ala Ser Val Trp His Asp Cys Ala 

        35                  40                  45              





Ser Gln Lys Lys Gly Cys Ala Val Tyr Leu His Val Ser Val Glu Phe 

    50                  55                  60                  





Asn Lys Leu Ile Pro Glu Asn Gly Phe Ile Lys Phe His Gln Val Arg 

65                  70                  75                  80  





Arg Val Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly 

                85                  90                  95      





Cys Met Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly 

            100                 105                 110         





Gly Leu Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val 

        115                 120                 125             





Asn Gly Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr 

    130                 135                 140                 





Phe Glu His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg 

145                 150                 155                 160 





Pro Asn Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val 

                165                 170                 175     





Met Leu Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu 

            180                 185                 190         





Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val 

        195                 200                 205             





Arg Arg His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp 

    210                 215                 220                 





Ser Ile Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp 

225                 230                 235                 240 





Met Ser Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys 

                245                 250                 255     





Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly 

            260                 265                 270         





Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser 

        275                 280                 285             





Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser 

    290                 295                 300                 





Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val 

305                 310                 315                 320 





Cys Thr Leu Thr Ile Lys Arg Gly Arg 

                325                 





<210>  40

<211>  3774

<212>  DNA

<213>  Homo sapiens



<400>  40

gtaaaccaat agcccccatg ctctgtgcga tttcattgtg tgctcgcgtt cgcaagctcc       60



gtagtgcagg aaggtgcggg aagttccacc aggtgagaag agtgatgacc atccttttcc      120



ttactatggt tatttcatac tttggttgca tgaaggctgc ccccatgaaa gaagcaaaca      180



tccgaggaca aggtggcttg gcctacccag gtgtgcggac ccatgggact ctggagagcg      240



tgaatgggcc caaggcaggt tcaagaggct tgacatcatt ggctgacact ttcgaacacg      300



tgatagaaga gctgttggat gaggaccaga aagttcggcc caatgaagaa aacaataagg      360



acgcagactt gtacacgtcc agggtgatgc tcagtagtca agtgcctttg gagcctcctc      420



ttctctttct gctggaggaa tacaaaaatt acctagatgc tgcaaacatg tccatgaggg      480



tccggcgcca ctctgaccct gcccgccgag gggagctgag cgtgtgtgac agtattagtg      540



agtgggtaac ggcggcagac aaaaagactg cagtggacat gtcgggcggg acggtcacag      600



tccttgaaaa ggtccctgta tcaaaaggcc aactgaagca atacttctac gagaccaagt      660



gcaatcccat gggttacaca aaagaaggct gcaggggcat agacaaaagg cattggaact      720



cccagtgccg aactacccag tcgtacgtgc gggcccttac catggatagc aaaaagagaa      780



ttggctggcg attcataagg atagacactt cttgtgtatg tacattgacc attaaaaggg      840



gaagatagtg gatttatgtt gtatagatta gattatattg agacaaaaat tatctatttg      900



tatatataca taacagggta aattattcag ttaagaaaaa aataatttta tgaactgcat      960



gtataaatga agtttataca gtacagtggt tctacaatct atttattgga catgtccatg     1020



accagaaggg aaacagtcat ttgcgcacaa cttaaaaagt ctgcattaca ttccttgata     1080



atgttgtggt ttgttgccgt tgccaagaac tgaaaacata aaaagttaaa aaaaataata     1140



aattgcatgc tgctttaatt gtgaattgat aataaactgt cctctttcag aaaacagaaa     1200



aaaacacaca cacacacaac aaaaatttga accaaaacat tccgtttaca ttttagacag     1260



taagtatctt cgttcttgtt agtactatat ctgttttact gcttttaact tctgatagcg     1320



ttggaattaa aacaatgtca aggtgctgtt gtcattgctt tactggctta ggggatgggg     1380



gatggggggt atatttttgt ttgttttgtg tttttttttc gtttgtttgt tttgtttttt     1440



agttcccaca gggagtagag atggggaaag aattcctaca atatatattc tggctgataa     1500



aagatacatt tgtatgttgt gaagatgttt gcaatatcga tcagatgact agaaagtgaa     1560



taaaaattaa ggcaactgaa caaaaaaatg ctcacactcc acatcccgtg atgcacctcc     1620



caggccccgc tcattctttg ggcgttggtc agagtaagct gcttttgacg gaaggaccta     1680



tgtttgctca gaacacattc tttccccccc tccccctctg gtctcctctt tgttttgttt     1740



taaggaagaa aaatcagttg cgcgttctga aatattttac cactgctgtg aacaagtgaa     1800



cacattgtgt cacatcatga cactcgtata agcatggaga acagtgattt ttttttagaa     1860



cagaaaacaa caaaaaataa ccccaaaatg aagattattt tttatgagga gtgaacattt     1920



gggtaaatca tggctaagct taaaaaaaac tcatggtgag gcttaacaat gtcttgtaag     1980



caaaaggtag agccctgtat caacccagaa acacctagat cagaacagga atccacattg     2040



ccagtgacat gagactgaac agccaaatgg aggctatgtg gagttggcat tgcatttacc     2100



ggcagtgcgg gaggaatttc tgagtggcca tcccaaggtc taggtggagg tggggcatgg     2160



tatttgagac attccaaaac gaaggcctct gaaggaccct tcagaggtgg ctctggaatg     2220



acatgtgtca agctgcttgg acctcgtgct ttaagtgcct acattatcta actgtgctca     2280



agaggttctc gactggagga ccacactcaa gccgacttat gcccaccatc ccacctctgg     2340



ataattttgc ataaaattgg attagcctgg agcaggttgg gagccaaatg tggcatttgt     2400



gatcatgaga ttgatgcaat gagatagaag atgtttgcta cctgaacact tattgctttg     2460



aaactagact tgaggaaacc agggtttatc ttttgagaac ttttggtaag ggaaaaggga     2520



acaggaaaag aaaccccaaa ctcaggccga atgatcaagg ggacccatag gaaatcttgt     2580



ccagagacaa gacttcggga aggtgtctgg acattcagaa caccaagact tgaaggtgcc     2640



ttgctcaatg gaagaggcca ggacagagct gacaaaattt tgctccccag tgaaggccac     2700



agcaaccttc tgcccatcct gtctgttcat ggagagggtc cctgcctcac ctctgccatt     2760



ttgggttagg agaagtcaag ttgggagcct gaaatagtgg ttcttggaaa aatggatccc     2820



cagtgaaaac tagagctcta agcccattca gcccatttca cacctgaaaa tgttagtgat     2880



caccacttgg accagcatcc ttaagtatca gaaagcccca agcaattgct gcatcttagt     2940



agggtgaggg ataagcaaaa gaggatgttc accataaccc aggaatgaag ataccatcag     3000



caaagaattt caatttgttc agtctttcat ttagagctag tctttcacag taccatctga     3060



atacctcttt gaaagaagga agactttacg tagtgtagat ttgttttgtg ttgtttgaaa     3120



atattatctt tgtaattatt tttaatatgt aaggaatgct tggaatatct gctatatgtc     3180



aactttatgc agcttccttt tgagggacaa atttaaaaca aacaaccccc catcacaaac     3240



ttaaaggatt gcaagggcca gatctgttaa gtggtttcat aggagacaca tccagcaatt     3300



gtgtggtcag tggctctttt acccaataag atacatcaca gtcacatgct tgatggttta     3360



tgttgaccta agatttattt tgttaaaatc tctctctgtt gtgttcgttc ttgttctgtt     3420



ttgttttgtt ttttaaagtc ttgctgtggt ctctttgtgg cagaagtgtt tcatgcatgg     3480



cagcaggcct gttgcttttt tatggcgatt cccattgaaa atgtaagtaa atgtctgtgg     3540



ccttgttctc tctatggtaa agatattatt caccatgtaa aacaaaaaac aatatttatt     3600



gtattttagt atatttatat aattatgtta ttgaaaaaaa ttggcattaa aacttaaccg     3660



catcagaacc tattgtaaat acaagttcta tttaagtgta ctaattaaca tataatatat     3720



gttttaaata tagaattttt aatgttttta aatatatttt caaagtacat aaaa           3774





<210>  41

<211>  276

<212>  PRT

<213>  Homo sapiens



<400>  41



Met Leu Cys Ala Ile Ser Leu Cys Ala Arg Val Arg Lys Leu Arg Ser 

1               5                   10                  15      





Ala Gly Arg Cys Gly Lys Phe His Gln Val Arg Arg Val Met Thr Ile 

            20                  25                  30          





Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met Lys Ala Ala 

        35                  40                  45              





Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu Ala Tyr Pro 

    50                  55                  60                  





Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly Pro Lys Ala 

65                  70                  75                  80  





Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu His Val Ile 

                85                  90                  95      





Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn Glu Glu Asn 

            100                 105                 110         





Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu Ser Ser Gln 

        115                 120                 125             





Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu Tyr Lys Asn 

    130                 135                 140                 





Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg His Ser Asp 

145                 150                 155                 160 





Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile Ser Glu Trp 

                165                 170                 175     





Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser Gly Gly Thr 

            180                 185                 190         





Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln Leu Lys Gln 

        195                 200                 205             





Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr Lys Glu Gly 

    210                 215                 220                 





Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys Arg Thr Thr 

225                 230                 235                 240 





Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys Arg Ile Gly 

                245                 250                 255     





Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr Leu Thr Ile 

            260                 265                 270         





Lys Arg Gly Arg 

        275     





<210>  42

<211>  3764

<212>  DNA

<213>  Homo sapiens



<400>  42

gtaaaccaat agcccccatg ctctgtgcga tttcattgtg tgctcgcgtt cgcaagctcc       60



gtagtgcagg aagttccacc aggtgagaag agtgatgacc atccttttcc ttactatggt      120



tatttcatac tttggttgca tgaaggctgc ccccatgaaa gaagcaaaca tccgaggaca      180



aggtggcttg gcctacccag gtgtgcggac ccatgggact ctggagagcg tgaatgggcc      240



caaggcaggt tcaagaggct tgacatcatt ggctgacact ttcgaacacg tgatagaaga      300



gctgttggat gaggaccaga aagttcggcc caatgaagaa aacaataagg acgcagactt      360



gtacacgtcc agggtgatgc tcagtagtca agtgcctttg gagcctcctc ttctctttct      420



gctggaggaa tacaaaaatt acctagatgc tgcaaacatg tccatgaggg tccggcgcca      480



ctctgaccct gcccgccgag gggagctgag cgtgtgtgac agtattagtg agtgggtaac      540



ggcggcagac aaaaagactg cagtggacat gtcgggcggg acggtcacag tccttgaaaa      600



ggtccctgta tcaaaaggcc aactgaagca atacttctac gagaccaagt gcaatcccat      660



gggttacaca aaagaaggct gcaggggcat agacaaaagg cattggaact cccagtgccg      720



aactacccag tcgtacgtgc gggcccttac catggatagc aaaaagagaa ttggctggcg      780



attcataagg atagacactt cttgtgtatg tacattgacc attaaaaggg gaagatagtg      840



gatttatgtt gtatagatta gattatattg agacaaaaat tatctatttg tatatataca      900



taacagggta aattattcag ttaagaaaaa aataatttta tgaactgcat gtataaatga      960



agtttataca gtacagtggt tctacaatct atttattgga catgtccatg accagaaggg     1020



aaacagtcat ttgcgcacaa cttaaaaagt ctgcattaca ttccttgata atgttgtggt     1080



ttgttgccgt tgccaagaac tgaaaacata aaaagttaaa aaaaataata aattgcatgc     1140



tgctttaatt gtgaattgat aataaactgt cctctttcag aaaacagaaa aaaacacaca     1200



cacacacaac aaaaatttga accaaaacat tccgtttaca ttttagacag taagtatctt     1260



cgttcttgtt agtactatat ctgttttact gcttttaact tctgatagcg ttggaattaa     1320



aacaatgtca aggtgctgtt gtcattgctt tactggctta ggggatgggg gatggggggt     1380



atatttttgt ttgttttgtg tttttttttc gtttgtttgt tttgtttttt agttcccaca     1440



gggagtagag atggggaaag aattcctaca atatatattc tggctgataa aagatacatt     1500



tgtatgttgt gaagatgttt gcaatatcga tcagatgact agaaagtgaa taaaaattaa     1560



ggcaactgaa caaaaaaatg ctcacactcc acatcccgtg atgcacctcc caggccccgc     1620



tcattctttg ggcgttggtc agagtaagct gcttttgacg gaaggaccta tgtttgctca     1680



gaacacattc tttccccccc tccccctctg gtctcctctt tgttttgttt taaggaagaa     1740



aaatcagttg cgcgttctga aatattttac cactgctgtg aacaagtgaa cacattgtgt     1800



cacatcatga cactcgtata agcatggaga acagtgattt ttttttagaa cagaaaacaa     1860



caaaaaataa ccccaaaatg aagattattt tttatgagga gtgaacattt gggtaaatca     1920



tggctaagct taaaaaaaac tcatggtgag gcttaacaat gtcttgtaag caaaaggtag     1980



agccctgtat caacccagaa acacctagat cagaacagga atccacattg ccagtgacat     2040



gagactgaac agccaaatgg aggctatgtg gagttggcat tgcatttacc ggcagtgcgg     2100



gaggaatttc tgagtggcca tcccaaggtc taggtggagg tggggcatgg tatttgagac     2160



attccaaaac gaaggcctct gaaggaccct tcagaggtgg ctctggaatg acatgtgtca     2220



agctgcttgg acctcgtgct ttaagtgcct acattatcta actgtgctca agaggttctc     2280



gactggagga ccacactcaa gccgacttat gcccaccatc ccacctctgg ataattttgc     2340



ataaaattgg attagcctgg agcaggttgg gagccaaatg tggcatttgt gatcatgaga     2400



ttgatgcaat gagatagaag atgtttgcta cctgaacact tattgctttg aaactagact     2460



tgaggaaacc agggtttatc ttttgagaac ttttggtaag ggaaaaggga acaggaaaag     2520



aaaccccaaa ctcaggccga atgatcaagg ggacccatag gaaatcttgt ccagagacaa     2580



gacttcggga aggtgtctgg acattcagaa caccaagact tgaaggtgcc ttgctcaatg     2640



gaagaggcca ggacagagct gacaaaattt tgctccccag tgaaggccac agcaaccttc     2700



tgcccatcct gtctgttcat ggagagggtc cctgcctcac ctctgccatt ttgggttagg     2760



agaagtcaag ttgggagcct gaaatagtgg ttcttggaaa aatggatccc cagtgaaaac     2820



tagagctcta agcccattca gcccatttca cacctgaaaa tgttagtgat caccacttgg     2880



accagcatcc ttaagtatca gaaagcccca agcaattgct gcatcttagt agggtgaggg     2940



ataagcaaaa gaggatgttc accataaccc aggaatgaag ataccatcag caaagaattt     3000



caatttgttc agtctttcat ttagagctag tctttcacag taccatctga atacctcttt     3060



gaaagaagga agactttacg tagtgtagat ttgttttgtg ttgtttgaaa atattatctt     3120



tgtaattatt tttaatatgt aaggaatgct tggaatatct gctatatgtc aactttatgc     3180



agcttccttt tgagggacaa atttaaaaca aacaaccccc catcacaaac ttaaaggatt     3240



gcaagggcca gatctgttaa gtggtttcat aggagacaca tccagcaatt gtgtggtcag     3300



tggctctttt acccaataag atacatcaca gtcacatgct tgatggttta tgttgaccta     3360



agatttattt tgttaaaatc tctctctgtt gtgttcgttc ttgttctgtt ttgttttgtt     3420



ttttaaagtc ttgctgtggt ctctttgtgg cagaagtgtt tcatgcatgg cagcaggcct     3480



gttgcttttt tatggcgatt cccattgaaa atgtaagtaa atgtctgtgg ccttgttctc     3540



tctatggtaa agatattatt caccatgtaa aacaaaaaac aatatttatt gtattttagt     3600



atatttatat aattatgtta ttgaaaaaaa ttggcattaa aacttaaccg catcagaacc     3660



tattgtaaat acaagttcta tttaagtgta ctaattaaca tataatatat gttttaaata     3720



tagaattttt aatgttttta aatatatttt caaagtacat aaaa                      3764





<210>  43

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  43



Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 

1               5                   10                  15      





Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 

            20                  25                  30          





Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 

        35                  40                  45              





Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 

    50                  55                  60                  





His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 

65                  70                  75                  80  





Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 

                85                  90                  95      





Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 

            100                 105                 110         





Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 

        115                 120                 125             





His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 

    130                 135                 140                 





Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 

145                 150                 155                 160 





Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 

                165                 170                 175     





Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 

            180                 185                 190         





Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 

        195                 200                 205             





Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 

    210                 215                 220                 





Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 

225                 230                 235                 240 





Leu Thr Ile Lys Arg Gly Arg 

                245         





<210>  44

<211>  3928

<212>  DNA

<213>  Homo sapiens



<400>  44

cttccacccc gccccctcct ccagcctcca tccctccctc attctatctc ttcctctccg       60



tcgccctcgc tcctcgctgg atgcttcttt ctgggttttc tttttttttt cccttctgtc      120



ctccctcccc gcgagtttcg ggcgctggct tagagggttc ccgctttctc aagggaaggg      180



gagctgccga gaccgcgctc cgctccccag ccgggccgga tgcctcactg agcccagttc      240



caccaggtga gaagagtgat gaccatcctt ttccttacta tggttatttc atactttggt      300



tgcatgaagg ctgcccccat gaaagaagca aacatccgag gacaaggtgg cttggcctac      360



ccaggtgtgc ggacccatgg gactctggag agcgtgaatg ggcccaaggc aggttcaaga      420



ggcttgacat cattggctga cactttcgaa cacgtgatag aagagctgtt ggatgaggac      480



cagaaagttc ggcccaatga agaaaacaat aaggacgcag acttgtacac gtccagggtg      540



atgctcagta gtcaagtgcc tttggagcct cctcttctct ttctgctgga ggaatacaaa      600



aattacctag atgctgcaaa catgtccatg agggtccggc gccactctga ccctgcccgc      660



cgaggggagc tgagcgtgtg tgacagtatt agtgagtggg taacggcggc agacaaaaag      720



actgcagtgg acatgtcggg cgggacggtc acagtccttg aaaaggtccc tgtatcaaaa      780



ggccaactga agcaatactt ctacgagacc aagtgcaatc ccatgggtta cacaaaagaa      840



ggctgcaggg gcatagacaa aaggcattgg aactcccagt gccgaactac ccagtcgtac      900



gtgcgggccc ttaccatgga tagcaaaaag agaattggct ggcgattcat aaggatagac      960



acttcttgtg tatgtacatt gaccattaaa aggggaagat agtggattta tgttgtatag     1020



attagattat attgagacaa aaattatcta tttgtatata tacataacag ggtaaattat     1080



tcagttaaga aaaaaataat tttatgaact gcatgtataa atgaagttta tacagtacag     1140



tggttctaca atctatttat tggacatgtc catgaccaga agggaaacag tcatttgcgc     1200



acaacttaaa aagtctgcat tacattcctt gataatgttg tggtttgttg ccgttgccaa     1260



gaactgaaaa cataaaaagt taaaaaaaat aataaattgc atgctgcttt aattgtgaat     1320



tgataataaa ctgtcctctt tcagaaaaca gaaaaaaaca cacacacaca caacaaaaat     1380



ttgaaccaaa acattccgtt tacattttag acagtaagta tcttcgttct tgttagtact     1440



atatctgttt tactgctttt aacttctgat agcgttggaa ttaaaacaat gtcaaggtgc     1500



tgttgtcatt gctttactgg cttaggggat gggggatggg gggtatattt ttgtttgttt     1560



tgtgtttttt tttcgtttgt ttgttttgtt ttttagttcc cacagggagt agagatgggg     1620



aaagaattcc tacaatatat attctggctg ataaaagata catttgtatg ttgtgaagat     1680



gtttgcaata tcgatcagat gactagaaag tgaataaaaa ttaaggcaac tgaacaaaaa     1740



aatgctcaca ctccacatcc cgtgatgcac ctcccaggcc ccgctcattc tttgggcgtt     1800



ggtcagagta agctgctttt gacggaagga cctatgtttg ctcagaacac attctttccc     1860



cccctccccc tctggtctcc tctttgtttt gttttaagga agaaaaatca gttgcgcgtt     1920



ctgaaatatt ttaccactgc tgtgaacaag tgaacacatt gtgtcacatc atgacactcg     1980



tataagcatg gagaacagtg attttttttt agaacagaaa acaacaaaaa ataaccccaa     2040



aatgaagatt attttttatg aggagtgaac atttgggtaa atcatggcta agcttaaaaa     2100



aaactcatgg tgaggcttaa caatgtcttg taagcaaaag gtagagccct gtatcaaccc     2160



agaaacacct agatcagaac aggaatccac attgccagtg acatgagact gaacagccaa     2220



atggaggcta tgtggagttg gcattgcatt taccggcagt gcgggaggaa tttctgagtg     2280



gccatcccaa ggtctaggtg gaggtggggc atggtatttg agacattcca aaacgaaggc     2340



ctctgaagga cccttcagag gtggctctgg aatgacatgt gtcaagctgc ttggacctcg     2400



tgctttaagt gcctacatta tctaactgtg ctcaagaggt tctcgactgg aggaccacac     2460



tcaagccgac ttatgcccac catcccacct ctggataatt ttgcataaaa ttggattagc     2520



ctggagcagg ttgggagcca aatgtggcat ttgtgatcat gagattgatg caatgagata     2580



gaagatgttt gctacctgaa cacttattgc tttgaaacta gacttgagga aaccagggtt     2640



tatcttttga gaacttttgg taagggaaaa gggaacagga aaagaaaccc caaactcagg     2700



ccgaatgatc aaggggaccc ataggaaatc ttgtccagag acaagacttc gggaaggtgt     2760



ctggacattc agaacaccaa gacttgaagg tgccttgctc aatggaagag gccaggacag     2820



agctgacaaa attttgctcc ccagtgaagg ccacagcaac cttctgccca tcctgtctgt     2880



tcatggagag ggtccctgcc tcacctctgc cattttgggt taggagaagt caagttggga     2940



gcctgaaata gtggttcttg gaaaaatgga tccccagtga aaactagagc tctaagccca     3000



ttcagcccat ttcacacctg aaaatgttag tgatcaccac ttggaccagc atccttaagt     3060



atcagaaagc cccaagcaat tgctgcatct tagtagggtg agggataagc aaaagaggat     3120



gttcaccata acccaggaat gaagatacca tcagcaaaga atttcaattt gttcagtctt     3180



tcatttagag ctagtctttc acagtaccat ctgaatacct ctttgaaaga aggaagactt     3240



tacgtagtgt agatttgttt tgtgttgttt gaaaatatta tctttgtaat tatttttaat     3300



atgtaaggaa tgcttggaat atctgctata tgtcaacttt atgcagcttc cttttgaggg     3360



acaaatttaa aacaaacaac cccccatcac aaacttaaag gattgcaagg gccagatctg     3420



ttaagtggtt tcataggaga cacatccagc aattgtgtgg tcagtggctc ttttacccaa     3480



taagatacat cacagtcaca tgcttgatgg tttatgttga cctaagattt attttgttaa     3540



aatctctctc tgttgtgttc gttcttgttc tgttttgttt tgttttttaa agtcttgctg     3600



tggtctcttt gtggcagaag tgtttcatgc atggcagcag gcctgttgct tttttatggc     3660



gattcccatt gaaaatgtaa gtaaatgtct gtggccttgt tctctctatg gtaaagatat     3720



tattcaccat gtaaaacaaa aaacaatatt tattgtattt tagtatattt atataattat     3780



gttattgaaa aaaattggca ttaaaactta accgcatcag aacctattgt aaatacaagt     3840



tctatttaag tgtactaatt aacatataat atatgtttta aatatagaat ttttaatgtt     3900



tttaaatata ttttcaaagt acataaaa                                        3928





<210>  45

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  45



Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 

1               5                   10                  15      





Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 

            20                  25                  30          





Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 

        35                  40                  45              





Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 

    50                  55                  60                  





His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 

65                  70                  75                  80  





Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 

                85                  90                  95      





Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 

            100                 105                 110         





Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 

        115                 120                 125             





His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 

    130                 135                 140                 





Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 

145                 150                 155                 160 





Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 

                165                 170                 175     





Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 

            180                 185                 190         





Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 

        195                 200                 205             





Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 

    210                 215                 220                 





Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 

225                 230                 235                 240 





Leu Thr Ile Lys Arg Gly Arg 

                245         





<210>  46

<211>  4042

<212>  DNA

<213>  Homo sapiens



<400>  46

aatatcaagt atcacttaat tagagatttt taagcctttt cctcctgctg tgccgggtgt       60



gtaatccggg cgataggagt ccattcagca ccttggacag agccaacgga tttgtccgag      120



gtggcggtac ccccaggtag tcttcttggc cccgctgtaa agccaaccct gtgtcgccct      180



taaaaagcgt cttttctgag gttcggctca cactgagatc ggggctggag agagagtcag      240



attttggagc ggagcgtttg gaaagcgagc cccagtttgg tcccctcatt gagctcgctg      300



aagttggctt cctagcggtg taggctggaa tagactcttg gcaagctccg gttccaccag      360



gtgagaagag tgatgaccat ccttttcctt actatggtta tttcatactt tggttgcatg      420



aaggctgccc ccatgaaaga agcaaacatc cgaggacaag gtggcttggc ctacccaggt      480



gtgcggaccc atgggactct ggagagcgtg aatgggccca aggcaggttc aagaggcttg      540



acatcattgg ctgacacttt cgaacacgtg atagaagagc tgttggatga ggaccagaaa      600



gttcggccca atgaagaaaa caataaggac gcagacttgt acacgtccag ggtgatgctc      660



agtagtcaag tgcctttgga gcctcctctt ctctttctgc tggaggaata caaaaattac      720



ctagatgctg caaacatgtc catgagggtc cggcgccact ctgaccctgc ccgccgaggg      780



gagctgagcg tgtgtgacag tattagtgag tgggtaacgg cggcagacaa aaagactgca      840



gtggacatgt cgggcgggac ggtcacagtc cttgaaaagg tccctgtatc aaaaggccaa      900



ctgaagcaat acttctacga gaccaagtgc aatcccatgg gttacacaaa agaaggctgc      960



aggggcatag acaaaaggca ttggaactcc cagtgccgaa ctacccagtc gtacgtgcgg     1020



gcccttacca tggatagcaa aaagagaatt ggctggcgat tcataaggat agacacttct     1080



tgtgtatgta cattgaccat taaaagggga agatagtgga tttatgttgt atagattaga     1140



ttatattgag acaaaaatta tctatttgta tatatacata acagggtaaa ttattcagtt     1200



aagaaaaaaa taattttatg aactgcatgt ataaatgaag tttatacagt acagtggttc     1260



tacaatctat ttattggaca tgtccatgac cagaagggaa acagtcattt gcgcacaact     1320



taaaaagtct gcattacatt ccttgataat gttgtggttt gttgccgttg ccaagaactg     1380



aaaacataaa aagttaaaaa aaataataaa ttgcatgctg ctttaattgt gaattgataa     1440



taaactgtcc tctttcagaa aacagaaaaa aacacacaca cacacaacaa aaatttgaac     1500



caaaacattc cgtttacatt ttagacagta agtatcttcg ttcttgttag tactatatct     1560



gttttactgc ttttaacttc tgatagcgtt ggaattaaaa caatgtcaag gtgctgttgt     1620



cattgcttta ctggcttagg ggatggggga tggggggtat atttttgttt gttttgtgtt     1680



tttttttcgt ttgtttgttt tgttttttag ttcccacagg gagtagagat ggggaaagaa     1740



ttcctacaat atatattctg gctgataaaa gatacatttg tatgttgtga agatgtttgc     1800



aatatcgatc agatgactag aaagtgaata aaaattaagg caactgaaca aaaaaatgct     1860



cacactccac atcccgtgat gcacctccca ggccccgctc attctttggg cgttggtcag     1920



agtaagctgc ttttgacgga aggacctatg tttgctcaga acacattctt tccccccctc     1980



cccctctggt ctcctctttg ttttgtttta aggaagaaaa atcagttgcg cgttctgaaa     2040



tattttacca ctgctgtgaa caagtgaaca cattgtgtca catcatgaca ctcgtataag     2100



catggagaac agtgattttt ttttagaaca gaaaacaaca aaaaataacc ccaaaatgaa     2160



gattattttt tatgaggagt gaacatttgg gtaaatcatg gctaagctta aaaaaaactc     2220



atggtgaggc ttaacaatgt cttgtaagca aaaggtagag ccctgtatca acccagaaac     2280



acctagatca gaacaggaat ccacattgcc agtgacatga gactgaacag ccaaatggag     2340



gctatgtgga gttggcattg catttaccgg cagtgcggga ggaatttctg agtggccatc     2400



ccaaggtcta ggtggaggtg gggcatggta tttgagacat tccaaaacga aggcctctga     2460



aggacccttc agaggtggct ctggaatgac atgtgtcaag ctgcttggac ctcgtgcttt     2520



aagtgcctac attatctaac tgtgctcaag aggttctcga ctggaggacc acactcaagc     2580



cgacttatgc ccaccatccc acctctggat aattttgcat aaaattggat tagcctggag     2640



caggttggga gccaaatgtg gcatttgtga tcatgagatt gatgcaatga gatagaagat     2700



gtttgctacc tgaacactta ttgctttgaa actagacttg aggaaaccag ggtttatctt     2760



ttgagaactt ttggtaaggg aaaagggaac aggaaaagaa accccaaact caggccgaat     2820



gatcaagggg acccatagga aatcttgtcc agagacaaga cttcgggaag gtgtctggac     2880



attcagaaca ccaagacttg aaggtgcctt gctcaatgga agaggccagg acagagctga     2940



caaaattttg ctccccagtg aaggccacag caaccttctg cccatcctgt ctgttcatgg     3000



agagggtccc tgcctcacct ctgccatttt gggttaggag aagtcaagtt gggagcctga     3060



aatagtggtt cttggaaaaa tggatcccca gtgaaaacta gagctctaag cccattcagc     3120



ccatttcaca cctgaaaatg ttagtgatca ccacttggac cagcatcctt aagtatcaga     3180



aagccccaag caattgctgc atcttagtag ggtgagggat aagcaaaaga ggatgttcac     3240



cataacccag gaatgaagat accatcagca aagaatttca atttgttcag tctttcattt     3300



agagctagtc tttcacagta ccatctgaat acctctttga aagaaggaag actttacgta     3360



gtgtagattt gttttgtgtt gtttgaaaat attatctttg taattatttt taatatgtaa     3420



ggaatgcttg gaatatctgc tatatgtcaa ctttatgcag cttccttttg agggacaaat     3480



ttaaaacaaa caacccccca tcacaaactt aaaggattgc aagggccaga tctgttaagt     3540



ggtttcatag gagacacatc cagcaattgt gtggtcagtg gctcttttac ccaataagat     3600



acatcacagt cacatgcttg atggtttatg ttgacctaag atttattttg ttaaaatctc     3660



tctctgttgt gttcgttctt gttctgtttt gttttgtttt ttaaagtctt gctgtggtct     3720



ctttgtggca gaagtgtttc atgcatggca gcaggcctgt tgctttttta tggcgattcc     3780



cattgaaaat gtaagtaaat gtctgtggcc ttgttctctc tatggtaaag atattattca     3840



ccatgtaaaa caaaaaacaa tatttattgt attttagtat atttatataa ttatgttatt     3900



gaaaaaaatt ggcattaaaa cttaaccgca tcagaaccta ttgtaaatac aagttctatt     3960



taagtgtact aattaacata taatatatgt tttaaatata gaatttttaa tgtttttaaa     4020



tatattttca aagtacataa aa                                              4042





<210>  47

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  47



Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 

1               5                   10                  15      





Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 

            20                  25                  30          





Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 

        35                  40                  45              





Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 

    50                  55                  60                  





His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 

65                  70                  75                  80  





Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 

                85                  90                  95      





Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 

            100                 105                 110         





Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 

        115                 120                 125             





His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 

    130                 135                 140                 





Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 

145                 150                 155                 160 





Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 

                165                 170                 175     





Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 

            180                 185                 190         





Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 

        195                 200                 205             





Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 

    210                 215                 220                 





Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 

225                 230                 235                 240 





Leu Thr Ile Lys Arg Gly Arg 

                245         





<210>  48

<211>  3827

<212>  DNA

<213>  Homo sapiens



<400>  48

aatatcaagt atcacttaat tagagatttt taagcctttt cctcctgctg tgccgggtgt       60



gtaatccggg cgataggagt ccattcagca ccttggacag agccaacgga tttgtccgag      120



gtggcggtac ccccagttcc accaggtgag aagagtgatg accatccttt tccttactat      180



ggttatttca tactttggtt gcatgaaggc tgcccccatg aaagaagcaa acatccgagg      240



acaaggtggc ttggcctacc caggtgtgcg gacccatggg actctggaga gcgtgaatgg      300



gcccaaggca ggttcaagag gcttgacatc attggctgac actttcgaac acgtgataga      360



agagctgttg gatgaggacc agaaagttcg gcccaatgaa gaaaacaata aggacgcaga      420



cttgtacacg tccagggtga tgctcagtag tcaagtgcct ttggagcctc ctcttctctt      480



tctgctggag gaatacaaaa attacctaga tgctgcaaac atgtccatga gggtccggcg      540



ccactctgac cctgcccgcc gaggggagct gagcgtgtgt gacagtatta gtgagtgggt      600



aacggcggca gacaaaaaga ctgcagtgga catgtcgggc gggacggtca cagtccttga      660



aaaggtccct gtatcaaaag gccaactgaa gcaatacttc tacgagacca agtgcaatcc      720



catgggttac acaaaagaag gctgcagggg catagacaaa aggcattgga actcccagtg      780



ccgaactacc cagtcgtacg tgcgggccct taccatggat agcaaaaaga gaattggctg      840



gcgattcata aggatagaca cttcttgtgt atgtacattg accattaaaa ggggaagata      900



gtggatttat gttgtataga ttagattata ttgagacaaa aattatctat ttgtatatat      960



acataacagg gtaaattatt cagttaagaa aaaaataatt ttatgaactg catgtataaa     1020



tgaagtttat acagtacagt ggttctacaa tctatttatt ggacatgtcc atgaccagaa     1080



gggaaacagt catttgcgca caacttaaaa agtctgcatt acattccttg ataatgttgt     1140



ggtttgttgc cgttgccaag aactgaaaac ataaaaagtt aaaaaaaata ataaattgca     1200



tgctgcttta attgtgaatt gataataaac tgtcctcttt cagaaaacag aaaaaaacac     1260



acacacacac aacaaaaatt tgaaccaaaa cattccgttt acattttaga cagtaagtat     1320



cttcgttctt gttagtacta tatctgtttt actgctttta acttctgata gcgttggaat     1380



taaaacaatg tcaaggtgct gttgtcattg ctttactggc ttaggggatg ggggatgggg     1440



ggtatatttt tgtttgtttt gtgttttttt ttcgtttgtt tgttttgttt tttagttccc     1500



acagggagta gagatgggga aagaattcct acaatatata ttctggctga taaaagatac     1560



atttgtatgt tgtgaagatg tttgcaatat cgatcagatg actagaaagt gaataaaaat     1620



taaggcaact gaacaaaaaa atgctcacac tccacatccc gtgatgcacc tcccaggccc     1680



cgctcattct ttgggcgttg gtcagagtaa gctgcttttg acggaaggac ctatgtttgc     1740



tcagaacaca ttctttcccc ccctccccct ctggtctcct ctttgttttg ttttaaggaa     1800



gaaaaatcag ttgcgcgttc tgaaatattt taccactgct gtgaacaagt gaacacattg     1860



tgtcacatca tgacactcgt ataagcatgg agaacagtga ttttttttta gaacagaaaa     1920



caacaaaaaa taaccccaaa atgaagatta ttttttatga ggagtgaaca tttgggtaaa     1980



tcatggctaa gcttaaaaaa aactcatggt gaggcttaac aatgtcttgt aagcaaaagg     2040



tagagccctg tatcaaccca gaaacaccta gatcagaaca ggaatccaca ttgccagtga     2100



catgagactg aacagccaaa tggaggctat gtggagttgg cattgcattt accggcagtg     2160



cgggaggaat ttctgagtgg ccatcccaag gtctaggtgg aggtggggca tggtatttga     2220



gacattccaa aacgaaggcc tctgaaggac ccttcagagg tggctctgga atgacatgtg     2280



tcaagctgct tggacctcgt gctttaagtg cctacattat ctaactgtgc tcaagaggtt     2340



ctcgactgga ggaccacact caagccgact tatgcccacc atcccacctc tggataattt     2400



tgcataaaat tggattagcc tggagcaggt tgggagccaa atgtggcatt tgtgatcatg     2460



agattgatgc aatgagatag aagatgtttg ctacctgaac acttattgct ttgaaactag     2520



acttgaggaa accagggttt atcttttgag aacttttggt aagggaaaag ggaacaggaa     2580



aagaaacccc aaactcaggc cgaatgatca aggggaccca taggaaatct tgtccagaga     2640



caagacttcg ggaaggtgtc tggacattca gaacaccaag acttgaaggt gccttgctca     2700



atggaagagg ccaggacaga gctgacaaaa ttttgctccc cagtgaaggc cacagcaacc     2760



ttctgcccat cctgtctgtt catggagagg gtccctgcct cacctctgcc attttgggtt     2820



aggagaagtc aagttgggag cctgaaatag tggttcttgg aaaaatggat ccccagtgaa     2880



aactagagct ctaagcccat tcagcccatt tcacacctga aaatgttagt gatcaccact     2940



tggaccagca tccttaagta tcagaaagcc ccaagcaatt gctgcatctt agtagggtga     3000



gggataagca aaagaggatg ttcaccataa cccaggaatg aagataccat cagcaaagaa     3060



tttcaatttg ttcagtcttt catttagagc tagtctttca cagtaccatc tgaatacctc     3120



tttgaaagaa ggaagacttt acgtagtgta gatttgtttt gtgttgtttg aaaatattat     3180



ctttgtaatt atttttaata tgtaaggaat gcttggaata tctgctatat gtcaacttta     3240



tgcagcttcc ttttgaggga caaatttaaa acaaacaacc ccccatcaca aacttaaagg     3300



attgcaaggg ccagatctgt taagtggttt cataggagac acatccagca attgtgtggt     3360



cagtggctct tttacccaat aagatacatc acagtcacat gcttgatggt ttatgttgac     3420



ctaagattta ttttgttaaa atctctctct gttgtgttcg ttcttgttct gttttgtttt     3480



gttttttaaa gtcttgctgt ggtctctttg tggcagaagt gtttcatgca tggcagcagg     3540



cctgttgctt ttttatggcg attcccattg aaaatgtaag taaatgtctg tggccttgtt     3600



ctctctatgg taaagatatt attcaccatg taaaacaaaa aacaatattt attgtatttt     3660



agtatattta tataattatg ttattgaaaa aaattggcat taaaacttaa ccgcatcaga     3720



acctattgta aatacaagtt ctatttaagt gtactaatta acatataata tatgttttaa     3780



atatagaatt tttaatgttt ttaaatatat tttcaaagta cataaaa                   3827





<210>  49

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  49



Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 

1               5                   10                  15      





Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 

            20                  25                  30          





Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 

        35                  40                  45              





Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 

    50                  55                  60                  





His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 

65                  70                  75                  80  





Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 

                85                  90                  95      





Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 

            100                 105                 110         





Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 

        115                 120                 125             





His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 

    130                 135                 140                 





Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 

145                 150                 155                 160 





Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 

                165                 170                 175     





Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 

            180                 185                 190         





Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 

        195                 200                 205             





Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 

    210                 215                 220                 





Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 

225                 230                 235                 240 





Leu Thr Ile Lys Arg Gly Arg 

                245         





<210>  50

<211>  949

<212>  DNA

<213>  Homo sapiens



<400>  50

ttttgtagat aaatgtgagg attttctcta aatccctctt ctgtttgcta aatctcactg       60



tcactgctaa attcagagca gatagagcct gcgcaatgga ataaagtcct caaaattgaa      120



atgtgacatt gctctcaaca tctcccatct ctctggattt ctttttgctt cattattcct      180



gctaaccaat tcattttcag actttgtact tcagaagcaa tgggaaaaat cagcagtctt      240



ccaacccaat tatttaagtg ctgcttttgt gatttcttga aggtgaagat gcacaccatg      300



tcctcctcgc atctcttcta cctggcgctg tgcctgctca ccttcaccag ctctgccacg      360



gctggaccgg agacgctctg cggggctgag ctggtggatg ctcttcagtt cgtgtgtgga      420



gacaggggct tttatttcaa caagcccaca gggtatggct ccagcagtcg gagggcgcct      480



cagacaggca tcgtggatga gtgctgcttc cggagctgtg atctaaggag gctggagatg      540



tattgcgcac ccctcaagcc tgccaagtca gctcgctctg tccgtgccca gcgccacacc      600



gacatgccca agacccagaa gtatcagccc ccatctacca acaagaacac gaagtctcag      660



agaaggaaag gttggccaaa gacacatcca ggaggggaac agaaggaggg gacagaagca      720



agtctgcaga tcagaggaaa gaagaaagag cagaggaggg agattggaag tagaaatgct      780



gaatgcagag gcaaaaaagg aaaatgaagg acaggaggat taaacagaca gaggcaagga      840



tgatgagaga ggagcagaca gcaagaatga aaagcagaaa atacaataga ggaaatgaag      900



aaaagtaggc ctgctggagc tagatgatga tgtgatggaa atagaagta                  949





<210>  51

<211>  195

<212>  PRT

<213>  Homo sapiens



<400>  51



Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 

1               5                   10                  15      





Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 

            20                  25                  30          





Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 

        35                  40                  45              





Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 

    50                  55                  60                  





Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 

65                  70                  75                  80  





Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 

                85                  90                  95      





Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 

            100                 105                 110         





Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 

        115                 120                 125             





Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 

    130                 135                 140                 





Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu 

145                 150                 155                 160 





Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys 

                165                 170                 175     





Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn Ala Glu Cys Arg Gly Lys 

            180                 185                 190         





Lys Gly Lys 

        195 





<210>  52

<211>  7204

<212>  DNA

<213>  Homo sapiens



<400>  52

gcatacctgc ctgggtgtcc aaatgtaact agatgctttc acaaacccca cccacaaagc       60



agcacatgtt tttaagactt cagttttcta ttcacatcgg cctcataata cccaccctga      120



cctgctgtaa aagacctgga acaaacaaaa atgattacac ctacagtgaa gatgcacacc      180



atgtcctcct cgcatctctt ctacctggcg ctgtgcctgc tcaccttcac cagctctgcc      240



acggctggac cggagacgct ctgcggggct gagctggtgg atgctcttca gttcgtgtgt      300



ggagacaggg gcttttattt caacaagccc acagggtatg gctccagcag tcggagggcg      360



cctcagacag gcatcgtgga tgagtgctgc ttccggagct gtgatctaag gaggctggag      420



atgtattgcg cacccctcaa gcctgccaag tcagctcgct ctgtccgtgc ccagcgccac      480



accgacatgc ccaagaccca gaaggaagta catttgaaga acgcaagtag agggagtgca      540



ggaaacaaga actacaggat gtaggaagac cctcctgagg agtgaagagt gacatgccac      600



cgcaggatcc tttgctctgc acgagttacc tgttaaactt tggaacacct accaaaaaat      660



aagtttgata acatttaaaa gatgggcgtt tcccccaatg aaatacacaa gtaaacattc      720



caacattgtc tttaggagtg atttgcacct tgcaaaaatg gtcctggagt tggtagattg      780



ctgttgatct tttatcaata atgttctata gaaaagaaaa aaaaaatata tatatatata      840



tatcttagtc cctgcctctc aagagccaca aatgcatggg tgttgtatag atccagttgc      900



actaaattcc tctctgaatc ttggctgctg gagccattca ttcagcaacc ttgtctaagt      960



ggtttatgaa ttgtttcctt atttgcactt ctttctacac aactcgggct gtttgtttta     1020



cagtgtctga taatcttgtt agtctatacc caccacctcc cttcataacc tttatatttg     1080



ccgaatttgg cctcctcaaa agcagcagca agtcgtcaag aagcacacca attctaaccc     1140



acaagattcc atctgtggca tttgtaccaa atataagttg gatgcatttt attttagaca     1200



caaagcttta tttttccaca tcatgcttac aaaaaagaat aatgcaaata gttgcaactt     1260



tgaggccaat catttttagg catatgtttt aaacatagaa agtttcttca actcaaaaga     1320



gttccttcaa atgatgagtt aatgtgcaac ctaattagta actttcctct ttttattttt     1380



tccatataga gcactatgta aatttagcat atcaattata caggatatat caaacagtat     1440



gtaaaactct gttttttagt ataatggtgc tattttgtag tttgttatat gaaagagtct     1500



ggccaaaacg gtaatacgtg aaagcaaaac aataggggaa gcctggagcc aaagatgaca     1560



caaggggaag ggtactgaaa acaccatcca tttgggaaag aaggcaaagt ccccccagtt     1620



atgccttcca agaggaactt cagacacaaa agtccactga tgcaaattgg actggcgagt     1680



ccagagagga aactgtggaa tggaaaaagc agaaggctag gaattttagc agtcctggtt     1740



tctttttctc atggaagaaa tgaacatctg ccagctgtgt catggactca ccactgtgtg     1800



accttgggca agtcacttca cctctctgtg cctcagtttc ctcatctgca aaatgggggc     1860



aatatgtcat ctacctacct caaaggggtg gtataaggtt taaaaagata aagattcaga     1920



ttttttttac cctgggttgc tgtaagggtg caacatcagg gcgcttgagt tgctgagatg     1980



caaggaattc tataaataac ccattcatag catagctaga gattggtgaa ttgaatgctc     2040



ctgacatctc agttcttgtc agtgaagcta tccaaataac tggccaacta gttgttaaaa     2100



gctaacagct caatctctta aaacactttt caaaatatgt gggaagcatt tgattttcaa     2160



tttgattttg aattctgcat ttggttttat gaatacaaag ataagtgaaa agagagaaag     2220



gaaaagaaaa aggagaaaaa caaagagatt tctaccagtg aaaggggaat taattactct     2280



ttgttagcac tcactgactc ttctatgcag ttactacata tctagtaaaa cctcgtttaa     2340



tactataaat aatattctat tcattttgaa aaacacaatg attccttctt ttctaggcaa     2400



tataaggaaa gtgatccaaa atttgaaata ttaaaataat atctaataaa aagtcacaaa     2460



gttatcttct ttaacaaact ttactcttat tcttagctgt atatacattt ttttaaaagt     2520



ttgttaaaat atgcttgact agagtttcca gttgaaaggc aaaaacttcc atcacaacaa     2580



gaaatttccc atgcctgctc agaagggtag cccctagctc tctgtgaatg tgttttatcc     2640



attcaactga aaattggtat caagaaagtc cactggttag tgtactagtc catcatagcc     2700



tagaaaatga tccctatctg cagatcaaga ttttctcatt agaacaatga attatccagc     2760



attcagatct ttctagtcac cttagaactt tttggttaaa agtacccagg cttgattatt     2820



tcatgcaaat tctatatttt acattcttgg aaagtctata tgaaaaacaa aaataacatc     2880



ttcagttttt ctcccactgg gtcacctcaa ggatcagagg ccaggaaaaa aaaaaaaaag     2940



actccctgga tctctgaata tatgcaaaaa gaaggcccca tttagtggag ccagcaatcc     3000



tgttcagtca acaagtattt taactctcag tccaacatta tttgaattga gcacctcaag     3060



catgcttagc aatgttctaa tcactatgga cagatgtaaa agaaactata catcattttt     3120



gccctctgcc tgttttccag acatacaggt tctgtggaat aagatactgg actcctcttc     3180



ccaagatggc acttcttttt atttcttgtc cccagtgtgt accttttaaa attattccct     3240



ctcaacaaaa ctttataggc agtcttctgc agacttaacg tgttttctgt catagttaga     3300



tgtgataatt ctaagagtgt ctatgactta tttccttcac ttaattctat ccacagtcaa     3360



aaatccccca aggaggaaag ctgaaagatg cactgccata ttatctttct taactttttc     3420



caacacataa tcctctccaa ctggattata aataaattga aaataactca ttataccaat     3480



tcactatttt attttttaat gaattaaaac tagaaaacaa attgatgcaa accctggaag     3540



tcagttgatt actatatact acagcagaat gactcagatt tcatagaaag gagcaaccaa     3600



aatgtcacaa cccaaaactt tacaagcttt gcttcagaat tagattgctt tataattctt     3660



gaatgaggca atttcaagat atttgtaaaa gaacagtaaa cattggtaag aatgagcttt     3720



caactcatag gcttatttcc aatttaattg accatactgg atacttaggt caaatttctg     3780



ttctctcttc cccaaataat attaaagtat tatttgaact ttttaagatg aggcagttcc     3840



cctgaaaaag ttaatgcagc tctccatcag aatccactct tctagggata tgaaaatctc     3900



ttaacaccca ccctacatac acagacacac acacacacac acacacacac acacacacac     3960



acattcaccc taaggatcca atggaatact gaaaagaaat cacttccttg aaaattttat     4020



taaaaaacaa acaaacaaac aaaaagcctg tccacccttg agaatccttc ctctccttgg     4080



aacgtcaatg tttgtgtaga tgaaaccatc tcatgctctg tggctccagg gtttctgtta     4140



ctattttatg cacttgggag aaggcttaga ataaaagatg tagcacattt tgctttccca     4200



tttattgttt ggccagctat gccaatgtgg tgctattgtt tctttaagaa agtacttgac     4260



taaaaaaaaa agaaaaaaag aaaaaaaaga aagcatagac atattttttt aaagtataaa     4320



aacaacaatt ctatagatag atggcttaat aaaatagcat taggtctatc tagccaccac     4380



cacctttcaa ctttttatca ctcacaagta gtgtactgtt caccaaattg tgaatttggg     4440



ggtgcagggg caggagttgg aaatttttta aagttagaag gctccattgt tttgttggct     4500



ctcaaactta gcaaaattag caatatatta tccaatcttc tgaacttgat caagagcatg     4560



gagaataaac gcgggaaaaa agatcttata ggcaaataga agaatttaaa agataagtaa     4620



gttccttatt gatttttgtg cactctgctc taaaacagat attcagcaag tggagaaaat     4680



aagaacaaag agaaaaaata catagattta cctgcaaaaa atagcttctg ccaaatcccc     4740



cttgggtatt ctttggcatt tactggttta tagaagacat tctcccttca cccagacatc     4800



tcaaagagca gtagctctca tgaaaagcaa tcactgatct catttgggaa atgttggaaa     4860



gtatttcctt atgagatggg ggttatctac tgataaagaa agaatttatg agaaattgtt     4920



gaaagagatg gctaacaatc tgtgaagatt ttttgtttct tgtttttgtt tttttttttt     4980



ttttacttta tacagtcttt atgaatttct taatgttcaa aatgacttgg ttcttttctt     5040



ctttttttat atcagaatga ggaataataa gttaaaccca catagactct ttaaaactat     5100



aggctagata gaaatgtatg tttgacttgt tgaagctata atcagactat ttaaaatgtt     5160



ttgctatttt taatcttaaa agattgtgct aatttattag agcagaacct gtttggctct     5220



cctcagaaga aagaatcttt ccattcaaat cacatggctt tccaccaata ttttcaaaag     5280



ataaatctga tttatgcaat ggcatcattt attttaaaac agaagaattg tgaaagttta     5340



tgcccctccc ttgcaaagac cataaagtcc agatctggta ggggggcaac aacaaaagga     5400



aaatgttgtt gattcttggt tttggatttt gttttgtttt caatgctagt gtttaatcct     5460



gtagtacata tttgcttatt gctattttaa tattttataa gaccttcctg ttaggtatta     5520



gaaagtgata catagatatc ttttttgtgt aatttctatt taaaaaagag agaagactgt     5580



cagaagcttt aagtgcatat ggtacaggat aaagatatca atttaaataa ccaattccta     5640



tctggaacaa tgcttttgtt ttttaaagaa acctctcaca gataagacag aggcccaggg     5700



gatttttgaa gctgtcttta ttctgccccc atcccaaccc agcccttatt attttagtat     5760



ctgcctcaga attttataga gggctgacca agctgaaact ctagaattaa aggaacctca     5820



ctgaaaacat atatttcacg tgttccctct tttttttttt cctttttgtg agatggggtc     5880



tcgcactgtc ccccaggctg gagtgcagtg gcatgatctc ggctcactgc aacctccacc     5940



tcctgggttt aagcgattct cctgcctcag cctcctgagt agctgggatt acaggcaccc     6000



accactatgc ccggctaatt ttttggattt ttaatagaga cggggtttta ccatgttggc     6060



caggttggtc tcaaactcct gaccttgtga tttgcccgcc tcagcctccc aaattgctgg     6120



gattacaggc atgagccacc acaccctgcc catgtgttcc ctcttaatgt atgattacat     6180



ggatcttaaa catgatcctt ctctcctcat tcttcaacta tctttgatgg ggtctttcaa     6240



ggggaaaaaa atccaagctt ttttaaagta aaaaaaaaaa aagagaggac acaaaaccaa     6300



atgttactgc tcaactgaaa tatgagttaa gatggagaca gagtttctcc taataaccgg     6360



agctgaatta cctttcactt tcaaaaacat gaccttccac aatccttaga atctgccttt     6420



ttttatatta ctgaggccta aaagtaaaca ttactcattt tattttgccc aaaatgcact     6480



gatgtaaagt aggaaaaata aaaacagagc tctaaaatcc ctttcaagcc acccattgac     6540



cccactcacc aactcatagc aaagtcactt ctgttaatcc cttaatctga ttttgtttgg     6600



atatttatct tgtacccgct gctaaacaca ctgcaggagg gactctgaaa cctcaagctg     6660



tctacttaca tcttttatct gtgtctgtgt atcatgaaaa tgtctattca aaatatcaaa     6720



acctttcaaa tatcacgcag cttatattca gtttacataa aggccccaaa taccatgtca     6780



gatctttttg gtaaaagagt taatgaacta tgagaattgg gattacatca tgtattttgc     6840



ctcatgtatt tttatcacac ttataggcca agtgtgataa ataaacttac agacactgaa     6900



ttaatttccc ctgctacttt gaaaccagaa aataatgact ggccattcgt tacatctgtc     6960



ttagttgaaa agcatatttt ttattaaatt aattctgatt gtatttgaaa ttattattca     7020



attcacttat ggcagaggaa tatcaatcct aatgacttct aaaaatgtaa ctaattgaat     7080



cattatctta catttactgt ttaataagca tattttgaaa atgtatggct agagtgtcat     7140



aataaaatgg tatatctttc tttagtaatt acattaaaat tagtcatgtt tgattaatta     7200



gttc                                                                  7204





<210>  53

<211>  137

<212>  PRT

<213>  Homo sapiens



<400>  53



Met Ile Thr Pro Thr Val Lys Met His Thr Met Ser Ser Ser His Leu 

1               5                   10                  15      





Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 

            20                  25                  30          





Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 

        35                  40                  45              





Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 

    50                  55                  60                  





Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 

65                  70                  75                  80  





Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 

                85                  90                  95      





Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 

            100                 105                 110         





Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 

        115                 120                 125             





Ser Ala Gly Asn Lys Asn Tyr Arg Met 

    130                 135         





<210>  54

<211>  7370

<212>  DNA

<213>  Homo sapiens



<400>  54

ttttgtagat aaatgtgagg attttctcta aatccctctt ctgtttgcta aatctcactg       60



tcactgctaa attcagagca gatagagcct gcgcaatgga ataaagtcct caaaattgaa      120



atgtgacatt gctctcaaca tctcccatct ctctggattt ctttttgctt cattattcct      180



gctaaccaat tcattttcag actttgtact tcagaagcaa tgggaaaaat cagcagtctt      240



ccaacccaat tatttaagtg ctgcttttgt gatttcttga aggtgaagat gcacaccatg      300



tcctcctcgc atctcttcta cctggcgctg tgcctgctca ccttcaccag ctctgccacg      360



gctggaccgg agacgctctg cggggctgag ctggtggatg ctcttcagtt cgtgtgtgga      420



gacaggggct tttatttcaa caagcccaca gggtatggct ccagcagtcg gagggcgcct      480



cagacaggca tcgtggatga gtgctgcttc cggagctgtg atctaaggag gctggagatg      540



tattgcgcac ccctcaagcc tgccaagtca gctcgctctg tccgtgccca gcgccacacc      600



gacatgccca agacccagaa gtatcagccc ccatctacca acaagaacac gaagtctcag      660



agaaggaaag gaagtacatt tgaagaacgc aagtagaggg agtgcaggaa acaagaacta      720



caggatgtag gaagaccctc ctgaggagtg aagagtgaca tgccaccgca ggatcctttg      780



ctctgcacga gttacctgtt aaactttgga acacctacca aaaaataagt ttgataacat      840



ttaaaagatg ggcgtttccc ccaatgaaat acacaagtaa acattccaac attgtcttta      900



ggagtgattt gcaccttgca aaaatggtcc tggagttggt agattgctgt tgatctttta      960



tcaataatgt tctatagaaa agaaaaaaaa aatatatata tatatatatc ttagtccctg     1020



cctctcaaga gccacaaatg catgggtgtt gtatagatcc agttgcacta aattcctctc     1080



tgaatcttgg ctgctggagc cattcattca gcaaccttgt ctaagtggtt tatgaattgt     1140



ttccttattt gcacttcttt ctacacaact cgggctgttt gttttacagt gtctgataat     1200



cttgttagtc tatacccacc acctcccttc ataaccttta tatttgccga atttggcctc     1260



ctcaaaagca gcagcaagtc gtcaagaagc acaccaattc taacccacaa gattccatct     1320



gtggcatttg taccaaatat aagttggatg cattttattt tagacacaaa gctttatttt     1380



tccacatcat gcttacaaaa aagaataatg caaatagttg caactttgag gccaatcatt     1440



tttaggcata tgttttaaac atagaaagtt tcttcaactc aaaagagttc cttcaaatga     1500



tgagttaatg tgcaacctaa ttagtaactt tcctcttttt attttttcca tatagagcac     1560



tatgtaaatt tagcatatca attatacagg atatatcaaa cagtatgtaa aactctgttt     1620



tttagtataa tggtgctatt ttgtagtttg ttatatgaaa gagtctggcc aaaacggtaa     1680



tacgtgaaag caaaacaata ggggaagcct ggagccaaag atgacacaag gggaagggta     1740



ctgaaaacac catccatttg ggaaagaagg caaagtcccc ccagttatgc cttccaagag     1800



gaacttcaga cacaaaagtc cactgatgca aattggactg gcgagtccag agaggaaact     1860



gtggaatgga aaaagcagaa ggctaggaat tttagcagtc ctggtttctt tttctcatgg     1920



aagaaatgaa catctgccag ctgtgtcatg gactcaccac tgtgtgacct tgggcaagtc     1980



acttcacctc tctgtgcctc agtttcctca tctgcaaaat gggggcaata tgtcatctac     2040



ctacctcaaa ggggtggtat aaggtttaaa aagataaaga ttcagatttt ttttaccctg     2100



ggttgctgta agggtgcaac atcagggcgc ttgagttgct gagatgcaag gaattctata     2160



aataacccat tcatagcata gctagagatt ggtgaattga atgctcctga catctcagtt     2220



cttgtcagtg aagctatcca aataactggc caactagttg ttaaaagcta acagctcaat     2280



ctcttaaaac acttttcaaa atatgtggga agcatttgat tttcaatttg attttgaatt     2340



ctgcatttgg ttttatgaat acaaagataa gtgaaaagag agaaaggaaa agaaaaagga     2400



gaaaaacaaa gagatttcta ccagtgaaag gggaattaat tactctttgt tagcactcac     2460



tgactcttct atgcagttac tacatatcta gtaaaacctc gtttaatact ataaataata     2520



ttctattcat tttgaaaaac acaatgattc cttcttttct aggcaatata aggaaagtga     2580



tccaaaattt gaaatattaa aataatatct aataaaaagt cacaaagtta tcttctttaa     2640



caaactttac tcttattctt agctgtatat acattttttt aaaagtttgt taaaatatgc     2700



ttgactagag tttccagttg aaaggcaaaa acttccatca caacaagaaa tttcccatgc     2760



ctgctcagaa gggtagcccc tagctctctg tgaatgtgtt ttatccattc aactgaaaat     2820



tggtatcaag aaagtccact ggttagtgta ctagtccatc atagcctaga aaatgatccc     2880



tatctgcaga tcaagatttt ctcattagaa caatgaatta tccagcattc agatctttct     2940



agtcacctta gaactttttg gttaaaagta cccaggcttg attatttcat gcaaattcta     3000



tattttacat tcttggaaag tctatatgaa aaacaaaaat aacatcttca gtttttctcc     3060



cactgggtca cctcaaggat cagaggccag gaaaaaaaaa aaaaagactc cctggatctc     3120



tgaatatatg caaaaagaag gccccattta gtggagccag caatcctgtt cagtcaacaa     3180



gtattttaac tctcagtcca acattatttg aattgagcac ctcaagcatg cttagcaatg     3240



ttctaatcac tatggacaga tgtaaaagaa actatacatc atttttgccc tctgcctgtt     3300



ttccagacat acaggttctg tggaataaga tactggactc ctcttcccaa gatggcactt     3360



ctttttattt cttgtcccca gtgtgtacct tttaaaatta ttccctctca acaaaacttt     3420



ataggcagtc ttctgcagac ttaacgtgtt ttctgtcata gttagatgtg ataattctaa     3480



gagtgtctat gacttatttc cttcacttaa ttctatccac agtcaaaaat cccccaagga     3540



ggaaagctga aagatgcact gccatattat ctttcttaac tttttccaac acataatcct     3600



ctccaactgg attataaata aattgaaaat aactcattat accaattcac tattttattt     3660



tttaatgaat taaaactaga aaacaaattg atgcaaaccc tggaagtcag ttgattacta     3720



tatactacag cagaatgact cagatttcat agaaaggagc aaccaaaatg tcacaaccca     3780



aaactttaca agctttgctt cagaattaga ttgctttata attcttgaat gaggcaattt     3840



caagatattt gtaaaagaac agtaaacatt ggtaagaatg agctttcaac tcataggctt     3900



atttccaatt taattgacca tactggatac ttaggtcaaa tttctgttct ctcttcccca     3960



aataatatta aagtattatt tgaacttttt aagatgaggc agttcccctg aaaaagttaa     4020



tgcagctctc catcagaatc cactcttcta gggatatgaa aatctcttaa cacccaccct     4080



acatacacag acacacacac acacacacac acacacacac acacacacat tcaccctaag     4140



gatccaatgg aatactgaaa agaaatcact tccttgaaaa ttttattaaa aaacaaacaa     4200



acaaacaaaa agcctgtcca cccttgagaa tccttcctct ccttggaacg tcaatgtttg     4260



tgtagatgaa accatctcat gctctgtggc tccagggttt ctgttactat tttatgcact     4320



tgggagaagg cttagaataa aagatgtagc acattttgct ttcccattta ttgtttggcc     4380



agctatgcca atgtggtgct attgtttctt taagaaagta cttgactaaa aaaaaaagaa     4440



aaaaagaaaa aaaagaaagc atagacatat ttttttaaag tataaaaaca acaattctat     4500



agatagatgg cttaataaaa tagcattagg tctatctagc caccaccacc tttcaacttt     4560



ttatcactca caagtagtgt actgttcacc aaattgtgaa tttgggggtg caggggcagg     4620



agttggaaat tttttaaagt tagaaggctc cattgttttg ttggctctca aacttagcaa     4680



aattagcaat atattatcca atcttctgaa cttgatcaag agcatggaga ataaacgcgg     4740



gaaaaaagat cttataggca aatagaagaa tttaaaagat aagtaagttc cttattgatt     4800



tttgtgcact ctgctctaaa acagatattc agcaagtgga gaaaataaga acaaagagaa     4860



aaaatacata gatttacctg caaaaaatag cttctgccaa atcccccttg ggtattcttt     4920



ggcatttact ggtttataga agacattctc ccttcaccca gacatctcaa agagcagtag     4980



ctctcatgaa aagcaatcac tgatctcatt tgggaaatgt tggaaagtat ttccttatga     5040



gatgggggtt atctactgat aaagaaagaa tttatgagaa attgttgaaa gagatggcta     5100



acaatctgtg aagatttttt gtttcttgtt tttgtttttt tttttttttt actttataca     5160



gtctttatga atttcttaat gttcaaaatg acttggttct tttcttcttt ttttatatca     5220



gaatgaggaa taataagtta aacccacata gactctttaa aactataggc tagatagaaa     5280



tgtatgtttg acttgttgaa gctataatca gactatttaa aatgttttgc tatttttaat     5340



cttaaaagat tgtgctaatt tattagagca gaacctgttt ggctctcctc agaagaaaga     5400



atctttccat tcaaatcaca tggctttcca ccaatatttt caaaagataa atctgattta     5460



tgcaatggca tcatttattt taaaacagaa gaattgtgaa agtttatgcc cctcccttgc     5520



aaagaccata aagtccagat ctggtagggg ggcaacaaca aaaggaaaat gttgttgatt     5580



cttggttttg gattttgttt tgttttcaat gctagtgttt aatcctgtag tacatatttg     5640



cttattgcta ttttaatatt ttataagacc ttcctgttag gtattagaaa gtgatacata     5700



gatatctttt ttgtgtaatt tctatttaaa aaagagagaa gactgtcaga agctttaagt     5760



gcatatggta caggataaag atatcaattt aaataaccaa ttcctatctg gaacaatgct     5820



tttgtttttt aaagaaacct ctcacagata agacagaggc ccaggggatt tttgaagctg     5880



tctttattct gcccccatcc caacccagcc cttattattt tagtatctgc ctcagaattt     5940



tatagagggc tgaccaagct gaaactctag aattaaagga acctcactga aaacatatat     6000



ttcacgtgtt ccctcttttt ttttttcctt tttgtgagat ggggtctcgc actgtccccc     6060



aggctggagt gcagtggcat gatctcggct cactgcaacc tccacctcct gggtttaagc     6120



gattctcctg cctcagcctc ctgagtagct gggattacag gcacccacca ctatgcccgg     6180



ctaatttttt ggatttttaa tagagacggg gttttaccat gttggccagg ttggtctcaa     6240



actcctgacc ttgtgatttg cccgcctcag cctcccaaat tgctgggatt acaggcatga     6300



gccaccacac cctgcccatg tgttccctct taatgtatga ttacatggat cttaaacatg     6360



atccttctct cctcattctt caactatctt tgatggggtc tttcaagggg aaaaaaatcc     6420



aagctttttt aaagtaaaaa aaaaaaaaga gaggacacaa aaccaaatgt tactgctcaa     6480



ctgaaatatg agttaagatg gagacagagt ttctcctaat aaccggagct gaattacctt     6540



tcactttcaa aaacatgacc ttccacaatc cttagaatct gccttttttt atattactga     6600



ggcctaaaag taaacattac tcattttatt ttgcccaaaa tgcactgatg taaagtagga     6660



aaaataaaaa cagagctcta aaatcccttt caagccaccc attgacccca ctcaccaact     6720



catagcaaag tcacttctgt taatccctta atctgatttt gtttggatat ttatcttgta     6780



cccgctgcta aacacactgc aggagggact ctgaaacctc aagctgtcta cttacatctt     6840



ttatctgtgt ctgtgtatca tgaaaatgtc tattcaaaat atcaaaacct ttcaaatatc     6900



acgcagctta tattcagttt acataaaggc cccaaatacc atgtcagatc tttttggtaa     6960



aagagttaat gaactatgag aattgggatt acatcatgta ttttgcctca tgtattttta     7020



tcacacttat aggccaagtg tgataaataa acttacagac actgaattaa tttcccctgc     7080



tactttgaaa ccagaaaata atgactggcc attcgttaca tctgtcttag ttgaaaagca     7140



tattttttat taaattaatt ctgattgtat ttgaaattat tattcaattc acttatggca     7200



gaggaatatc aatcctaatg acttctaaaa atgtaactaa ttgaatcatt atcttacatt     7260



tactgtttaa taagcatatt ttgaaaatgt atggctagag tgtcataata aaatggtata     7320



tctttcttta gtaattacat taaaattagt catgtttgat taattagttc                7370





<210>  55

<211>  158

<212>  PRT

<213>  Homo sapiens



<400>  55



Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 

1               5                   10                  15      





Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 

            20                  25                  30          





Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 

        35                  40                  45              





Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 

    50                  55                  60                  





Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 

65                  70                  75                  80  





Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 

                85                  90                  95      





Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 

            100                 105                 110         





Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 

        115                 120                 125             





Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 

    130                 135                 140                 





Lys Ser Gln Arg Arg Lys Gly Ser Thr Phe Glu Glu Arg Lys 

145                 150                 155             





<210>  56

<211>  7321

<212>  DNA

<213>  Homo sapiens



<400>  56

ttttgtagat aaatgtgagg attttctcta aatccctctt ctgtttgcta aatctcactg       60



tcactgctaa attcagagca gatagagcct gcgcaatgga ataaagtcct caaaattgaa      120



atgtgacatt gctctcaaca tctcccatct ctctggattt ctttttgctt cattattcct      180



gctaaccaat tcattttcag actttgtact tcagaagcaa tgggaaaaat cagcagtctt      240



ccaacccaat tatttaagtg ctgcttttgt gatttcttga aggtgaagat gcacaccatg      300



tcctcctcgc atctcttcta cctggcgctg tgcctgctca ccttcaccag ctctgccacg      360



gctggaccgg agacgctctg cggggctgag ctggtggatg ctcttcagtt cgtgtgtgga      420



gacaggggct tttatttcaa caagcccaca gggtatggct ccagcagtcg gagggcgcct      480



cagacaggca tcgtggatga gtgctgcttc cggagctgtg atctaaggag gctggagatg      540



tattgcgcac ccctcaagcc tgccaagtca gctcgctctg tccgtgccca gcgccacacc      600



gacatgccca agacccagaa ggaagtacat ttgaagaacg caagtagagg gagtgcagga      660



aacaagaact acaggatgta ggaagaccct cctgaggagt gaagagtgac atgccaccgc      720



aggatccttt gctctgcacg agttacctgt taaactttgg aacacctacc aaaaaataag      780



tttgataaca tttaaaagat gggcgtttcc cccaatgaaa tacacaagta aacattccaa      840



cattgtcttt aggagtgatt tgcaccttgc aaaaatggtc ctggagttgg tagattgctg      900



ttgatctttt atcaataatg ttctatagaa aagaaaaaaa aaatatatat atatatatat      960



cttagtccct gcctctcaag agccacaaat gcatgggtgt tgtatagatc cagttgcact     1020



aaattcctct ctgaatcttg gctgctggag ccattcattc agcaaccttg tctaagtggt     1080



ttatgaattg tttccttatt tgcacttctt tctacacaac tcgggctgtt tgttttacag     1140



tgtctgataa tcttgttagt ctatacccac cacctccctt cataaccttt atatttgccg     1200



aatttggcct cctcaaaagc agcagcaagt cgtcaagaag cacaccaatt ctaacccaca     1260



agattccatc tgtggcattt gtaccaaata taagttggat gcattttatt ttagacacaa     1320



agctttattt ttccacatca tgcttacaaa aaagaataat gcaaatagtt gcaactttga     1380



ggccaatcat ttttaggcat atgttttaaa catagaaagt ttcttcaact caaaagagtt     1440



ccttcaaatg atgagttaat gtgcaaccta attagtaact ttcctctttt tattttttcc     1500



atatagagca ctatgtaaat ttagcatatc aattatacag gatatatcaa acagtatgta     1560



aaactctgtt ttttagtata atggtgctat tttgtagttt gttatatgaa agagtctggc     1620



caaaacggta atacgtgaaa gcaaaacaat aggggaagcc tggagccaaa gatgacacaa     1680



ggggaagggt actgaaaaca ccatccattt gggaaagaag gcaaagtccc cccagttatg     1740



ccttccaaga ggaacttcag acacaaaagt ccactgatgc aaattggact ggcgagtcca     1800



gagaggaaac tgtggaatgg aaaaagcaga aggctaggaa ttttagcagt cctggtttct     1860



ttttctcatg gaagaaatga acatctgcca gctgtgtcat ggactcacca ctgtgtgacc     1920



ttgggcaagt cacttcacct ctctgtgcct cagtttcctc atctgcaaaa tgggggcaat     1980



atgtcatcta cctacctcaa aggggtggta taaggtttaa aaagataaag attcagattt     2040



tttttaccct gggttgctgt aagggtgcaa catcagggcg cttgagttgc tgagatgcaa     2100



ggaattctat aaataaccca ttcatagcat agctagagat tggtgaattg aatgctcctg     2160



acatctcagt tcttgtcagt gaagctatcc aaataactgg ccaactagtt gttaaaagct     2220



aacagctcaa tctcttaaaa cacttttcaa aatatgtggg aagcatttga ttttcaattt     2280



gattttgaat tctgcatttg gttttatgaa tacaaagata agtgaaaaga gagaaaggaa     2340



aagaaaaagg agaaaaacaa agagatttct accagtgaaa ggggaattaa ttactctttg     2400



ttagcactca ctgactcttc tatgcagtta ctacatatct agtaaaacct cgtttaatac     2460



tataaataat attctattca ttttgaaaaa cacaatgatt ccttcttttc taggcaatat     2520



aaggaaagtg atccaaaatt tgaaatatta aaataatatc taataaaaag tcacaaagtt     2580



atcttcttta acaaacttta ctcttattct tagctgtata tacatttttt taaaagtttg     2640



ttaaaatatg cttgactaga gtttccagtt gaaaggcaaa aacttccatc acaacaagaa     2700



atttcccatg cctgctcaga agggtagccc ctagctctct gtgaatgtgt tttatccatt     2760



caactgaaaa ttggtatcaa gaaagtccac tggttagtgt actagtccat catagcctag     2820



aaaatgatcc ctatctgcag atcaagattt tctcattaga acaatgaatt atccagcatt     2880



cagatctttc tagtcacctt agaacttttt ggttaaaagt acccaggctt gattatttca     2940



tgcaaattct atattttaca ttcttggaaa gtctatatga aaaacaaaaa taacatcttc     3000



agtttttctc ccactgggtc acctcaagga tcagaggcca ggaaaaaaaa aaaaaagact     3060



ccctggatct ctgaatatat gcaaaaagaa ggccccattt agtggagcca gcaatcctgt     3120



tcagtcaaca agtattttaa ctctcagtcc aacattattt gaattgagca cctcaagcat     3180



gcttagcaat gttctaatca ctatggacag atgtaaaaga aactatacat catttttgcc     3240



ctctgcctgt tttccagaca tacaggttct gtggaataag atactggact cctcttccca     3300



agatggcact tctttttatt tcttgtcccc agtgtgtacc ttttaaaatt attccctctc     3360



aacaaaactt tataggcagt cttctgcaga cttaacgtgt tttctgtcat agttagatgt     3420



gataattcta agagtgtcta tgacttattt ccttcactta attctatcca cagtcaaaaa     3480



tcccccaagg aggaaagctg aaagatgcac tgccatatta tctttcttaa ctttttccaa     3540



cacataatcc tctccaactg gattataaat aaattgaaaa taactcatta taccaattca     3600



ctattttatt ttttaatgaa ttaaaactag aaaacaaatt gatgcaaacc ctggaagtca     3660



gttgattact atatactaca gcagaatgac tcagatttca tagaaaggag caaccaaaat     3720



gtcacaaccc aaaactttac aagctttgct tcagaattag attgctttat aattcttgaa     3780



tgaggcaatt tcaagatatt tgtaaaagaa cagtaaacat tggtaagaat gagctttcaa     3840



ctcataggct tatttccaat ttaattgacc atactggata cttaggtcaa atttctgttc     3900



tctcttcccc aaataatatt aaagtattat ttgaactttt taagatgagg cagttcccct     3960



gaaaaagtta atgcagctct ccatcagaat ccactcttct agggatatga aaatctctta     4020



acacccaccc tacatacaca gacacacaca cacacacaca cacacacaca cacacacaca     4080



ttcaccctaa ggatccaatg gaatactgaa aagaaatcac ttccttgaaa attttattaa     4140



aaaacaaaca aacaaacaaa aagcctgtcc acccttgaga atccttcctc tccttggaac     4200



gtcaatgttt gtgtagatga aaccatctca tgctctgtgg ctccagggtt tctgttacta     4260



ttttatgcac ttgggagaag gcttagaata aaagatgtag cacattttgc tttcccattt     4320



attgtttggc cagctatgcc aatgtggtgc tattgtttct ttaagaaagt acttgactaa     4380



aaaaaaaaga aaaaaagaaa aaaaagaaag catagacata tttttttaaa gtataaaaac     4440



aacaattcta tagatagatg gcttaataaa atagcattag gtctatctag ccaccaccac     4500



ctttcaactt tttatcactc acaagtagtg tactgttcac caaattgtga atttgggggt     4560



gcaggggcag gagttggaaa ttttttaaag ttagaaggct ccattgtttt gttggctctc     4620



aaacttagca aaattagcaa tatattatcc aatcttctga acttgatcaa gagcatggag     4680



aataaacgcg ggaaaaaaga tcttataggc aaatagaaga atttaaaaga taagtaagtt     4740



ccttattgat ttttgtgcac tctgctctaa aacagatatt cagcaagtgg agaaaataag     4800



aacaaagaga aaaaatacat agatttacct gcaaaaaata gcttctgcca aatccccctt     4860



gggtattctt tggcatttac tggtttatag aagacattct cccttcaccc agacatctca     4920



aagagcagta gctctcatga aaagcaatca ctgatctcat ttgggaaatg ttggaaagta     4980



tttccttatg agatgggggt tatctactga taaagaaaga atttatgaga aattgttgaa     5040



agagatggct aacaatctgt gaagattttt tgtttcttgt ttttgttttt tttttttttt     5100



tactttatac agtctttatg aatttcttaa tgttcaaaat gacttggttc ttttcttctt     5160



tttttatatc agaatgagga ataataagtt aaacccacat agactcttta aaactatagg     5220



ctagatagaa atgtatgttt gacttgttga agctataatc agactattta aaatgttttg     5280



ctatttttaa tcttaaaaga ttgtgctaat ttattagagc agaacctgtt tggctctcct     5340



cagaagaaag aatctttcca ttcaaatcac atggctttcc accaatattt tcaaaagata     5400



aatctgattt atgcaatggc atcatttatt ttaaaacaga agaattgtga aagtttatgc     5460



ccctcccttg caaagaccat aaagtccaga tctggtaggg gggcaacaac aaaaggaaaa     5520



tgttgttgat tcttggtttt ggattttgtt ttgttttcaa tgctagtgtt taatcctgta     5580



gtacatattt gcttattgct attttaatat tttataagac cttcctgtta ggtattagaa     5640



agtgatacat agatatcttt tttgtgtaat ttctatttaa aaaagagaga agactgtcag     5700



aagctttaag tgcatatggt acaggataaa gatatcaatt taaataacca attcctatct     5760



ggaacaatgc ttttgttttt taaagaaacc tctcacagat aagacagagg cccaggggat     5820



ttttgaagct gtctttattc tgcccccatc ccaacccagc ccttattatt ttagtatctg     5880



cctcagaatt ttatagaggg ctgaccaagc tgaaactcta gaattaaagg aacctcactg     5940



aaaacatata tttcacgtgt tccctctttt tttttttcct ttttgtgaga tggggtctcg     6000



cactgtcccc caggctggag tgcagtggca tgatctcggc tcactgcaac ctccacctcc     6060



tgggtttaag cgattctcct gcctcagcct cctgagtagc tgggattaca ggcacccacc     6120



actatgcccg gctaattttt tggattttta atagagacgg ggttttacca tgttggccag     6180



gttggtctca aactcctgac cttgtgattt gcccgcctca gcctcccaaa ttgctgggat     6240



tacaggcatg agccaccaca ccctgcccat gtgttccctc ttaatgtatg attacatgga     6300



tcttaaacat gatccttctc tcctcattct tcaactatct ttgatggggt ctttcaaggg     6360



gaaaaaaatc caagcttttt taaagtaaaa aaaaaaaaag agaggacaca aaaccaaatg     6420



ttactgctca actgaaatat gagttaagat ggagacagag tttctcctaa taaccggagc     6480



tgaattacct ttcactttca aaaacatgac cttccacaat ccttagaatc tgcctttttt     6540



tatattactg aggcctaaaa gtaaacatta ctcattttat tttgcccaaa atgcactgat     6600



gtaaagtagg aaaaataaaa acagagctct aaaatccctt tcaagccacc cattgacccc     6660



actcaccaac tcatagcaaa gtcacttctg ttaatccctt aatctgattt tgtttggata     6720



tttatcttgt acccgctgct aaacacactg caggagggac tctgaaacct caagctgtct     6780



acttacatct tttatctgtg tctgtgtatc atgaaaatgt ctattcaaaa tatcaaaacc     6840



tttcaaatat cacgcagctt atattcagtt tacataaagg ccccaaatac catgtcagat     6900



ctttttggta aaagagttaa tgaactatga gaattgggat tacatcatgt attttgcctc     6960



atgtattttt atcacactta taggccaagt gtgataaata aacttacaga cactgaatta     7020



atttcccctg ctactttgaa accagaaaat aatgactggc cattcgttac atctgtctta     7080



gttgaaaagc atatttttta ttaaattaat tctgattgta tttgaaatta ttattcaatt     7140



cacttatggc agaggaatat caatcctaat gacttctaaa aatgtaacta attgaatcat     7200



tatcttacat ttactgttta ataagcatat tttgaaaatg tatggctaga gtgtcataat     7260



aaaatggtat atctttcttt agtaattaca ttaaaattag tcatgtttga ttaattagtt     7320



c                                                                     7321





<210>  57

<211>  153

<212>  PRT

<213>  Homo sapiens



<400>  57



Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 

1               5                   10                  15      





Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 

            20                  25                  30          





Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 

        35                  40                  45              





Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 

    50                  55                  60                  





Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 

65                  70                  75                  80  





Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 

                85                  90                  95      





Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 

            100                 105                 110         





Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 

        115                 120                 125             





Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 

    130                 135                 140                 





Ser Ala Gly Asn Lys Asn Tyr Arg Met 

145                 150             





<210>  58

<211>  6774

<212>  DNA

<213>  Homo sapiens



<400>  58

cggccccaga aaacccgagc gagtaggggg cggcgcgcag gagggaggag aactgggggc       60



gcgggaggct ggtgggtgtg gggggtggag atgtagaaga tgtgacgccg cggcccggcg      120



ggtgccagat tagcggacgc ggtgcccgcg gttgcaacgg gatcccgggc gctgcagctt      180



gggaggcggc tctccccagg cggcgtccgc ggagacaccc atccgtgaac cccaggtccc      240



gggccgccgg ctcgccgcgc accaggggcc ggcggacaga agagcggccg agcggctcga      300



ggctggggga ccgcgggcgc ggccgcgcgc tgccgggcgg gaggctgggg ggccggggcc      360



ggggccgtgc cccggagcgg gtcggaggcc ggggccgggg ccgggggacg gcggctcccc      420



gcgcggctcc agcggctcgg ggatcccggc cgggccccgc agggaccatg gcagccggga      480



gcatcaccac gctgcccgcc ttgcccgagg atggcggcag cggcgccttc ccgcccggcc      540



acttcaagga ccccaagcgg ctgtactgca aaaacggggg cttcttcctg cgcatccacc      600



ccgacggccg agttgacggg gtccgggaga agagcgaccc tcacatcaag ctacaacttc      660



aagcagaaga gagaggagtt gtgtctatca aaggagtgtg tgctaaccgt tacctggcta      720



tgaaggaaga tggaagatta ctggcttcta aatgtgttac ggatgagtgt ttcttttttg      780



aacgattgga atctaataac tacaatactt accggtcaag gaaatacacc agttggtatg      840



tggcactgaa acgaactggg cagtataaac ttggatccaa aacaggacct gggcagaaag      900



ctatactttt tcttccaatg tctgctaaga gctgatttta atggccacat ctaatctcat      960



ttcacatgaa agaagaagta tattttagaa atttgttaat gagagtaaaa gaaaataaat     1020



gtgtatagct cagtttggat aattggtcaa acaatttttt atccagtagt aaaatatgta     1080



accattgtcc cagtaaagaa aaataacaaa agttgtaaaa tgtatattct cccttttata     1140



ttgcatctgc tgttacccag tgaagcttac ctagagcaat gatctttttc acgcatttgc     1200



tttattcgaa aagaggcttt taaaatgtgc atgtttagaa acaaaatttc ttcatggaaa     1260



tcatatacat tagaaaatca cagtcagatg tttaatcaat ccaaaatgtc cactatttct     1320



tatgtcattc gttagtctac atgtttctaa acatataaat gtgaatttaa tcaattcctt     1380



tcatagtttt ataattctct ggcagttcct tatgatagag tttataaaac agtcctgtgt     1440



aaactgctgg aagttcttcc acagtcaggt caattttgtc aaacccttct ctgtacccat     1500



acagcagcag cctagcaact ctgctggtga tgggagttgt attttcagtc ttcgccaggt     1560



cattgagatc catccactca catcttaagc attcttcctg gcaaaaattt atggtgaatg     1620



aatatggctt taggcggcag atgatataca tatctgactt cccaaaagct ccaggatttg     1680



tgtgctgttg ccgaatactc aggacggacc tgaattctga ttttatacca gtctcttcaa     1740



aaacttctcg aaccgctgtg tctcctacgt aaaaaaagag atgtacaaat caataataat     1800



tacactttta gaaactgtat catcaaagat tttcagttaa agtagcatta tgtaaaggct     1860



caaaacatta ccctaacaaa gtaaagtttt caatacaaat tctttgcctt gtggatatca     1920



agaaatccca aaatattttc ttaccactgt aaattcaaga agcttttgaa atgctgaata     1980



tttctttggc tgctacttgg aggcttatct acctgtacat ttttggggtc agctcttttt     2040



aacttcttgc tgctcttttt cccaaaaggt aaaaatatag attgaaaagt taaaacattt     2100



tgcatggctg cagttccttt gtttcttgag ataagattcc aaagaactta gattcatttc     2160



ttcaacaccg aaatgctgga ggtgtttgat cagttttcaa gaaacttgga atataaataa     2220



ttttataatt caacaaaggt tttcacattt tataaggttg atttttcaat taaatgcaaa     2280



tttgtgtggc aggattttta ttgccattaa catatttttg tggctgcttt ttctacacat     2340



ccagatggtc cctctaactg ggctttctct aattttgtga tgttctgtca ttgtctccca     2400



aagtatttag gagaagccct ttaaaaagct gccttcctct accactttgc tggaaagctt     2460



cacaattgtc acagacaaag atttttgttc caatactcgt tttgcctcta tttttcttgt     2520



ttgtcaaata gtaaatgata tttgcccttg cagtaattct actggtgaaa aacatgcaaa     2580



gaagaggaag tcacagaaac atgtctcaat tcccatgtgc tgtgactgta gactgtctta     2640



ccatagactg tcttacccat cccctggata tgctcttgtt ttttccctct aatagctatg     2700



gaaagatgca tagaaagagt ataatgtttt aaaacataag gcattcgtct gccatttttc     2760



aattacatgc tgacttccct tacaattgag atttgcccat aggttaaaca tggttagaaa     2820



caactgaaag cataaaagaa aaatctaggc cgggtgcagt ggctcatgcc tatattccct     2880



gcactttggg aggccaaagc aggaggatcg cttgagccca ggagttcaag accaacctgg     2940



tgaaaccccg tctctacaaa aaaacacaaa aaatagccag gcatggtggc gtgtacatgt     3000



ggtctcagat acttgggagg ctgaggtggg agggttgatc acttgaggct gagaggtcaa     3060



ggttgcagtg agccataatc gtgccactgc agtccagcct aggcaacaga gtgagacttt     3120



gtctcaaaaa aagagaaatt ttccttaata agaaaagtaa tttttactct gatgtgcaat     3180



acatttgtta ttaaatttat tatttaagat ggtagcacta gtcttaaatt gtataaaata     3240



tcccctaaca tgtttaaatg tccattttta ttcattatgc tttgaaaaat aattatgggg     3300



aaatacatgt ttgttattaa atttattatt aaagatagta gcactagtct taaatttgat     3360



ataacatctc ctaacttgtt taaatgtcca tttttattct ttatgtttga aaataaatta     3420



tggggatcct atttagctct tagtaccact aatcaaaagt tcggcatgta gctcatgatc     3480



tatgctgttt ctatgtcgtg gaagcaccgg atgggggtag tgagcaaatc tgccctgctc     3540



agcagtcacc atagcagctg actgaaaatc agcactgcct gagtagtttt gatcagttta     3600



acttgaatca ctaactgact gaaaattgaa tgggcaaata agtgcttttg tctccagagt     3660



atgcgggaga cccttccacc tcaagatgga tatttcttcc ccaaggattt caagatgaat     3720



tgaaattttt aatcaagata gtgtgcttta ttctgttgta ttttttatta ttttaatata     3780



ctgtaagcca aactgaaata acatttgctg ttttataggt ttgaagaaca taggaaaaac     3840



taagaggttt tgtttttatt tttgctgatg aagagatatg tttaaatatg ttgtattgtt     3900



ttgtttagtt acaggacaat aatgaaatgg agtttatatt tgttatttct attttgttat     3960



atttaataat agaattagat tgaaataaaa tataatggga aataatctgc agaatgtggg     4020



ttttcctggt gtttccctct gactctagtg cactgatgat ctctgataag gctcagctgc     4080



tttatagttc tctggctaat gcagcagata ctcttcctgc cagtggtaat acgatttttt     4140



aagaaggcag tttgtcaatt ttaatcttgt ggataccttt atactcttag ggtattattt     4200



tatacaaaag ccttgaggat tgcattctat tttctatatg accctcttga tatttaaaaa     4260



acactatgga taacaattct tcatttacct agtattatga aagaatgaag gagttcaaac     4320



aaatgtgttt cccagttaac tagggtttac tgtttgagcc aatataaatg tttaactgtt     4380



tgtgatggca gtattcctaa agtacattgc atgttttcct aaatacagag tttaaataat     4440



ttcagtaatt cttagatgat tcagcttcat cattaagaat atcttttgtt ttatgttgag     4500



ttagaaatgc cttcatatag acatagtctt tcagacctct actgtcagtt ttcatttcta     4560



gctgctttca gggttttatg aattttcagg caaagcttta atttatacta agcttaggaa     4620



gtatggctaa tgccaacggc agtttttttc ttcttaattc cacatgactg aggcatatat     4680



gatctctggg taggtgagtt gttgtgacaa ccacaagcac tttttttttt tttaaagaaa     4740



aaaaggtagt gaatttttaa tcatctggac tttaagaagg attctggagt atacttaggc     4800



ctgaaattat atatatttgg cttggaaatg tgtttttctt caattacatc tacaagtaag     4860



tacagctgaa attcagagga cccataagag ttcacatgaa aaaaatcaat ttatttgaaa     4920



aggcaagatg caggagagag gaagccttgc aaacctgcag actgcttttt gcccaatata     4980



gattgggtaa ggctgcaaaa cataagctta attagctcac atgctctgct ctcacgtggc     5040



accagtggat agtgtgagag aattaggctg tagaacaaat ggccttctct ttcagcattc     5100



acaccactac aaaatcatct tttatatcaa cagaagaata agcataaact aagcaaaagg     5160



tcaataagta cctgaaacca agattggcta gagatatatc ttaatgcaat ccattttctg     5220



atggattgtt acgagttggc tatataatgt atgtatggta ttttgatttg tgtaaaagtt     5280



ttaaaaatca agctttaagt acatggacat ttttaaataa aatatttaaa gacaatttag     5340



aaaattgcct taatatcatt gttggctaaa tagaataggg gacatgcata ttaaggaaaa     5400



ggtcatggag aaataatatt ggtatcaaac aaatacattg atttgtcatg atacacattg     5460



aatttgatcc aatagtttaa ggaataggta ggaaaatttg gtttctattt ttcgatttcc     5520



tgtaaatcag tgacataaat aattcttagc ttattttata tttccttgtc ttaaatactg     5580



agctcagtaa gttgtgttag gggattattt ctcagttgag actttcttat atgacatttt     5640



actatgtttt gacttcctga ctattaaaaa taaatagtag atacaatttt cataaagtga     5700



agaattatat aatcactgct ttataactga ctttattata tttatttcaa agttcattta     5760



aaggctacta ttcatcctct gtgatggaat ggtcaggaat ttgttttctc atagtttaat     5820



tccaacaaca atattagtcg tatccaaaat aacctttaat gctaaacttt actgatgtat     5880



atccaaagct tctcattttc agacagatta atccagaagc agtcataaac agaagaatag     5940



gtggtatgtt cctaatgata ttatttctac taatggaata aactgtaata ttagaaatta     6000



tgctgctaat tatatcagct ctgaggtaat ttctgaaatg ttcagactca gtcggaacaa     6060



attggaaaat ttaaattttt attcttagct ataaagcaag aaagtaaaca cattaatttc     6120



ctcaacattt ttaagccaat taaaaatata aaagatacac accaatatct tcttcaggct     6180



ctgacaggcc tcctggaaac ttccacatat ttttcaactg cagtataaag tcagaaaata     6240



aagttaacat aactttcact aacacacaca tatgtagatt tcacaaaatc cacctataat     6300



tggtcaaagt ggttgagaat atatttttta gtaattgcat gcaaaatttt tctagcttcc     6360



atcctttctc cctcgtttct tctttttttg ggggagctgg taactgatga aatcttttcc     6420



caccttttct cttcaggaaa tataagtggt tttgtttggt taacgtgata cattctgtat     6480



gaatgaaaca ttggagggaa acatctactg aatttctgta atttaaaata ttttgctgct     6540



agttaactat gaacagatag aagaatctta cagatgctgc tataaataag tagaaaatat     6600



aaatttcatc actaaaatat gctattttaa aatctatttc ctatattgta tttctaatca     6660



gatgtattac tcttattatt tctattgtat gtgttaatga ttttatgtaa aaatgtaatt     6720



gcttttcatg agtagtatga ataaaattga ttagtttgtg ttttcttgtc tccc           6774





<210>  59

<211>  288

<212>  PRT

<213>  Homo sapiens



<400>  59



Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 

1               5                   10                  15      





Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 

            20                  25                  30          





Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 

        35                  40                  45              





Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 

    50                  55                  60                  





Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 

65                  70                  75                  80  





Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 

                85                  90                  95      





Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 

            100                 105                 110         





Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 

        115                 120                 125             





Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 

    130                 135                 140                 





Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 

145                 150                 155                 160 





Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 

                165                 170                 175     





His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 

            180                 185                 190         





Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 

        195                 200                 205             





Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 

    210                 215                 220                 





Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 

225                 230                 235                 240 





Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 

                245                 250                 255     





Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 

            260                 265                 270         





Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 

        275                 280                 285             





<210>  60

<211>  1914

<212>  DNA

<213>  Homo sapiens



<400>  60

agagtcacat ctcttatttg gaccagtata gacagaagta aacccagctg acttgtttcc       60



tgggacagtt gagttaaggg atggctttca cagagcattc accgctgacc cctcaccgtc      120



gggacctctg tagccgctct atctggctag caaggaagat tcgttcagac ctgactgctc      180



ttacggaatc ctatgtgaag catcagggcc tgaacaagaa catcaacctg gactctgcgg      240



atgggatgcc agtggcaagc actgatcagt ggagtgagct gaccgaggca gagcgactcc      300



aagagaacct tcaagcttat cgtaccttcc atgttttgtt ggccaggctc ttagaagacc      360



agcaggtgca ttttacccca accgaaggtg acttccatca agctatacat acccttcttc      420



tccaagtcgc tgcctttgca taccagatag aggagttaat gatactcctg gaatacaaga      480



tcccccgcaa tgaggctgat gggatgccta ttaatgttgg agatggtggt ctctttgaga      540



agaagctgtg gggcctaaag gtgctgcagg agctttcaca gtggacagta aggtccatcc      600



atgaccttcg tttcatttct tctcatcaga ctgggatccc agcacgtggg agccattata      660



ttgctaacaa caagaaaatg tagcagttag tcccttctct cttccttgct ttctcttcta      720



atggaatatg cgtagttccc tggggcctcg ctttcccatc ttaaatttct aaaaacagtt      780



aagacaacag gcattttctt tcttttttct ctgaccacct gcagcctgtt gaaggactac      840



aggtattttc atcaagtagc gttggagaca tacacaaatg ggcatacaag tttagcctgg      900



ggggtgtgat ttgtgtgcgt gcttgcatgt gctgcaggtg taagagagtg ggagcaggga      960



caacgtcctt ccacttcagg gttctaacct ttctaaccca ctaagtaacc tctacaggca     1020



tttaactgcc ttacagacag aatatacata tgttaattct agtcctggat gactcggtct     1080



gagaagattc aatttaaaat cagactcttt agttgattta aactcttaga gaataagaat     1140



aataatggct aacttttatt atcttctata ttaaggcagt atgccaaggg tctttatgta     1200



tattatgtac agcgtttaca accttgtgag caaggtggtg ttactcccat taggtagatg     1260



agaaaacagg ctcacagaga tttggttaag ctcacacagc taacaagtag cacactgagt     1320



ttgaacacag atcattctcc ttgtaaaagc ctatgtgcct ttcactttag aggcttgatc     1380



atgaatcact gcacctcttt gtcacagggt gttggaagat gcatccatgt aatctattcc     1440



catcgctgga aaacagctgc tgttagatgt cctcagaagt cagttgcaaa ttttagcgtt     1500



aaagtcagga tttattgttc atacttggcg gtgaggaggg cagctggaga tcttaagatt     1560



ccattttgga aaatgattag gcccgccaaa cttctgaact ttggaagctg gggatgttta     1620



gtaatacagc ctggttttta agtactcact aaaagttctc aaatattggg ttgggcacgg     1680



cttataccag gttacctcac ttttaattag tgatgcaggc agtgtaaccc aagcatttgt     1740



ggacaatgag tggaatacta aagttaaaaa gtcaaacttt cacctcagat tttctggact     1800



tagtcatgag gagagggtga ggcccactct gttcctactg gagataccag agactctgaa     1860



actatagaat aaagcctctg tgctgcacaa caaaaaaaaa aaaaaaaaaa aaaa           1914





<210>  61

<211>  200

<212>  PRT

<213>  Homo sapiens



<400>  61



Met Ala Phe Thr Glu His Ser Pro Leu Thr Pro His Arg Arg Asp Leu 

1               5                   10                  15      





Cys Ser Arg Ser Ile Trp Leu Ala Arg Lys Ile Arg Ser Asp Leu Thr 

            20                  25                  30          





Ala Leu Thr Glu Ser Tyr Val Lys His Gln Gly Leu Asn Lys Asn Ile 

        35                  40                  45              





Asn Leu Asp Ser Ala Asp Gly Met Pro Val Ala Ser Thr Asp Gln Trp 

    50                  55                  60                  





Ser Glu Leu Thr Glu Ala Glu Arg Leu Gln Glu Asn Leu Gln Ala Tyr 

65                  70                  75                  80  





Arg Thr Phe His Val Leu Leu Ala Arg Leu Leu Glu Asp Gln Gln Val 

                85                  90                  95      





His Phe Thr Pro Thr Glu Gly Asp Phe His Gln Ala Ile His Thr Leu 

            100                 105                 110         





Leu Leu Gln Val Ala Ala Phe Ala Tyr Gln Ile Glu Glu Leu Met Ile 

        115                 120                 125             





Leu Leu Glu Tyr Lys Ile Pro Arg Asn Glu Ala Asp Gly Met Pro Ile 

    130                 135                 140                 





Asn Val Gly Asp Gly Gly Leu Phe Glu Lys Lys Leu Trp Gly Leu Lys 

145                 150                 155                 160 





Val Leu Gln Glu Leu Ser Gln Trp Thr Val Arg Ser Ile His Asp Leu 

                165                 170                 175     





Arg Phe Ile Ser Ser His Gln Thr Gly Ile Pro Ala Arg Gly Ser His 

            180                 185                 190         





Tyr Ile Ala Asn Asn Lys Lys Met 

        195                 200 





<210>  62

<211>  99

<212>  PRT

<213>  Homo sapiens



<400>  62



Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Ile Ala Ala Thr 

1               5                   10                  15      





Phe Ile Pro Gln Gly Leu Ala Gln Pro Asp Ala Ile Asn Ala Pro Val 

            20                  25                  30          





Thr Cys Cys Tyr Asn Phe Thr Asn Arg Lys Ile Ser Val Gln Arg Leu 

        35                  40                  45              





Ala Ser Tyr Arg Arg Ile Thr Ser Ser Lys Cys Pro Lys Glu Ala Val 

    50                  55                  60                  





Ile Phe Lys Thr Ile Val Ala Lys Glu Ile Cys Ala Asp Pro Lys Gln 

65                  70                  75                  80  





Lys Trp Val Gln Asp Ser Met Asp His Leu Asp Lys Gln Thr Gln Thr 

                85                  90                  95      





Pro Lys Thr 

            





<210>  63

<211>  1237

<212>  DNA

<213>  Homo sapiens



<400>  63

gctgcagagg attcctgcag aggatcaaga cagcacgtgg acctcgcaca gcctctccca       60



caggtaccat gaaggtctcc gcggcagccc tcgctgtcat cctcattgct actgccctct      120



gcgctcctgc atctgcctcc ccatattcct cggacaccac accctgctgc tttgcctaca      180



ttgcccgccc actgccccgt gcccacatca aggagtattt ctacaccagt ggcaagtgct      240



ccaacccagc agtcgtcttt gtcacccgaa agaaccgcca agtgtgtgcc aacccagaga      300



agaaatgggt tcgggagtac atcaactctt tggagatgag ctaggatgga gagtccttga      360



acctgaactt acacaaattt gcctgtttct gcttgctctt gtcctagctt gggaggcttc      420



ccctcactat cctaccccac ccgctccttg aagggcccag attctaccac acagcagcag      480



ttacaaaaac cttccccagg ctggacgtgg tggctcacgc ctgtaatccc agcactttgg      540



gaggccaagg tgggtggatc acttgaggtc aggagttcga gaccagcctg gccaacatga      600



tgaaacccca tctctactaa aaatacaaaa aattagccgg gcgtggtagc gggcgcctgt      660



agtcccagct actcgggagg ctgaggcagg agaatggcgt gaacccggga ggcggagctt      720



gcagtgagcc gagatcgcgc cactgcactc cagcctgggc gacagagcga gactccgtct      780



caaaaaaaaa aaaaaaaaaa aaaatacaaa aattagccgg gcgtggtggc ccacgcctgt      840



aatcccagct actcgggagg ctaaggcagg aaaattgttt gaacccagga ggtggaggct      900



gcagtgagct gagattgtgc cacttcactc cagcctgggt gacaaagtga gactccgtca      960



caacaacaac aacaaaaagc ttccccaact aaagcctaga agagcttctg aggcgctgct     1020



ttgtcaaaag gaagtctcta ggttctgagc tctggctttg ccttggcttt gccagggctc     1080



tgtgaccagg aaggaagtca gcatgcctct agaggcaagg aggggaggaa cactgcactc     1140



ttaagcttcc gccgtctcaa cccctcacag gagcttactg gcaaacatga aaaatcggct     1200



taccattaaa gttctcaatg caaccataaa aaaaaaa                              1237





<210>  64

<211>  91

<212>  PRT

<213>  Homo sapiens



<400>  64



Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala 

1               5                   10                  15      





Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 

            20                  25                  30          





Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 

        35                  40                  45              





Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe 

    50                  55                  60                  





Val Thr Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp 

65                  70                  75                  80  





Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser 

                85                  90      





<210>  65

<211>  1184

<212>  DNA

<213>  Homo sapiens



<400>  65

gggggagaca ttcctcaatt gcttagacat attctgagcc tacagcagag gaacctccag       60



tctcagcacc atgaatcaaa ctgccattct gatttgctgc cttatctttc tgactctaag      120



tggcattcaa ggagtacctc tctctagaac tgtacgctgt acctgcatca gcattagtaa      180



tcaacctgtt aatccaaggt ctttagaaaa acttgaaatt attcctgcaa gccaattttg      240



tccacgtgtt gagatcattg ctacaatgaa aaagaagggt gagaagagat gtctgaatcc      300



agaatcgaag gccatcaaga atttactgaa agcagttagc aaggaaaggt ctaaaagatc      360



tccttaaaac cagaggggag caaaatcgat gcagtgcttc caaggatgga ccacacagag      420



gctgcctctc ccatcacttc cctacatgga gtatatgtca agccataatt gttcttagtt      480



tgcagttaca ctaaaaggtg accaatgatg gtcaccaaat cagctgctac tactcctgta      540



ggaaggttaa tgttcatcat cctaagctat tcagtaataa ctctaccctg gcactataat      600



gtaagctcta ctgaggtgct atgttcttag tggatgttct gaccctgctt caaatatttc      660



cctcaccttt cccatcttcc aagggtacta aggaatcttt ctgctttggg gtttatcaga      720



attctcagaa tctcaaataa ctaaaaggta tgcaatcaaa tctgcttttt aaagaatgct      780



ctttacttca tggacttcca ctgccatcct cccaaggggc ccaaattctt tcagtggcta      840



cctacataca attccaaaca catacaggaa ggtagaaata tctgaaaatg tatgtgtaag      900



tattcttatt taatgaaaga ctgtacaaag tagaagtctt agatgtatat atttcctata      960



ttgttttcag tgtacatgga ataacatgta attaagtact atgtatcaat gagtaacagg     1020



aaaattttaa aaatacagat agatatatgc tctgcatgtt acataagata aatgtgctga     1080



atggttttca aaataaaaat gaggtactct cctggaaata ttaagaaaga ctatctaaat     1140



gttgaaagat caaaaggtta ataaagtaat tataactaaa aaaa                      1184





<210>  66

<211>  98

<212>  PRT

<213>  Homo sapiens



<400>  66



Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 

1               5                   10                  15      





Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 

            20                  25                  30          





Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 

        35                  40                  45              





Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 

    50                  55                  60                  





Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 

65                  70                  75                  80  





Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 

                85                  90                  95      





Ser Pro 

        





<210>  67

<211>  3304

<212>  DNA

<213>  Homo sapiens



<400>  67

ctgagctctg ccgcctggct ctagccgcct gcctggcccc cgccgggact cttgcccacc       60



ctcagccatg gctccgatat ctctgtcgtg gctgctccgc ttggccacct tctgccatct      120



gactgtcctg ctggctggac agcaccacgg tgtgacgaaa tgcaacatca cgtgcagcaa      180



gatgacatca aagatacctg tagctttgct catccactat caacagaacc aggcatcatg      240



cggcaaacgc gcaatcatct tggagacgag acagcacagg ctgttctgtg ccgacccgaa      300



ggagcaatgg gtcaaggacg cgatgcagca tctggaccgc caggctgctg ccctaactcg      360



aaatggcggc accttcgaga agcagatcgg cgaggtgaag cccaggacca cccctgccgc      420



cgggggaatg gacgagtctg tggtcctgga gcccgaagcc acaggcgaaa gcagtagcct      480



ggagccgact ccttcttccc aggaagcaca gagggccctg gggacctccc cagagctgcc      540



gacgggcgtg actggttcct cagggaccag gctccccccg acgccaaagg ctcaggatgg      600



agggcctgtg ggcacggagc ttttccgagt gcctcccgtc tccactgccg ccacgtggca      660



gagttctgct ccccaccaac ctgggcccag cctctgggct gaggcaaaga cctctgaggc      720



cccgtccacc caggacccct ccacccaggc ctccactgcg tcctccccag ccccagagga      780



gaatgctccg tctgaaggcc agcgtgtgtg gggtcaggga cagagcccca ggccagagaa      840



ctctctggag cgggaggaga tgggtcccgt gccagcgcac acggatgcct tccaggactg      900



ggggcctggc agcatggccc acgtctctgt ggtccctgtc tcctcagaag ggacccccag      960



cagggagcca gtggcttcag gcagctggac ccctaaggct gaggaaccca tccatgccac     1020



catggacccc cagaggctgg gcgtccttat cactcctgtc cctgacgccc aggctgccac     1080



ccggaggcag gcggtggggc tgctggcctt ccttggcctc ctcttctgcc tgggggtggc     1140



catgttcacc taccagagcc tccagggctg ccctcgaaag atggcaggag agatggcgga     1200



gggccttcgc tacatccccc ggagctgtgg tagtaattca tatgtcctgg tgcccgtgtg     1260



aactcctctg gcctgtgtct agttgtttga ttcagacagc tgcctgggat ccctcatcct     1320



catacccacc cccacccaag ggcctggcct gagctgggat gattggaggg gggaggtggg     1380



atcctccagg tgcacaagct ccaagctccc aggcattccc caggaggcca gccttgacca     1440



ttctccacct tccagggaca gagggggtgg cctcccaact caccccagcc ccaaaactct     1500



cctctgctgc tggctggtta gaggttccct ttgacgccat cccagcccca atgaacaatt     1560



atttattaaa tgcccagccc cttctgaccc atgctgccct gtgagtacta cagtcctccc     1620



atctcacaca tgagcatcag gccaggccct ctgcccactc cctgcaacct gattgtgtct     1680



cttggtcctg ctgcagttgc cagtcacccc ggccacctgc ggtgctatct cccccagccc     1740



catcctctgt acagagccca cgcccccact ggtgacatgt cttttcttgc atgaggctag     1800



tgtggtgttt cctggcactg cttccagtga ggctctgccc ttggttaggc attgtgggaa     1860



ggggagataa gggtatctgg tgactttcct ctttggtcta cactgtgctg agtctgaagg     1920



ctgggttctg atcctagttc caccatcaag ccaccaacat actcccatct gtgaaaggaa     1980



agagggaggt aaggaatacc tgtccccctg acaacactca ttgacctgag gcccttctct     2040



ccagcccctg gatgcagcct cacagtcctt accagcagag caccttagac agtccctgcc     2100



aatggactaa cttgtctttg gaccctgagg cccagagggc ctgcaaggga gtgagttgat     2160



agcacagacc ctgccctgtg ggcccccaaa tggaaatggg cagagcagag accatccctg     2220



aaggccccgc ccaggcttag tcactgagac agcccgggct ctgcctccca tcacccgcta     2280



agagggaggg agggctccag acacatgtcc aagaagccca ggaaaggctc caggagcagc     2340



cacattcctg atgcttcttc agagactcct gcaggcagcc aggccacaag acccttgtgg     2400



tcccacccca cacacgccag attctttcct gaggctgggc tcccttccca cctctctcac     2460



tccttgaaaa cactgttctc tgccctccaa gaccttctcc ttcacctttg tccccaccgc     2520



agacaggacc agggatttcc atgatgtttt ccatgagtcc cctgtttgtt tctgaaaggg     2580



acgctacccg ggaagggggc tgggacatgg gaaaggggaa gttgtaggca taaagtcagg     2640



ggttcccttt tttggctgct gaaggctcga gcatgcctgg atggggctgc accggctggc     2700



ctggcccctc agggtccctg gtggcagctc acctctccct tggattgtcc ccgacccttg     2760



ccgtctacct gaggggcctc ttatgggctg ggttctaccc aggtgctagg aacactcctt     2820



cacagatggg tgcttggagg aaggaaaccc agctctggtc catagagagc aagacgctgt     2880



gctgccctgc ccacctggcc tctgcactcc cctgctgggt gtggcgcagc atattcagga     2940



agctcagggc ctggctcagg tggggtcact ctggcagctc agagagggtg ggagtgggtc     3000



caatgcactt tgttctggct cttccaggct gggagagcct ttcaggggtg ggacaccctg     3060



tgatggggcc ctgcctcctt tgtgaggaag ccgctggggc cagttggtcc cccttccatg     3120



gactttgtta gtttctccaa gcaggacatg gacaaggatg atctaggaag actttggaaa     3180



gagtaggaag actttggaaa gacttttcca accctcatca ccaacgtctg tgccattttg     3240



tattttacta ataaaattta aaagtcttgt gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3300



aaaa                                                                  3304





<210>  68

<211>  397

<212>  PRT

<213>  Homo sapiens



<400>  68



Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Thr Phe Cys 

1               5                   10                  15      





His Leu Thr Val Leu Leu Ala Gly Gln His His Gly Val Thr Lys Cys 

            20                  25                  30          





Asn Ile Thr Cys Ser Lys Met Thr Ser Lys Ile Pro Val Ala Leu Leu 

        35                  40                  45              





Ile His Tyr Gln Gln Asn Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile 

    50                  55                  60                  





Leu Glu Thr Arg Gln His Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln 

65                  70                  75                  80  





Trp Val Lys Asp Ala Met Gln His Leu Asp Arg Gln Ala Ala Ala Leu 

                85                  90                  95      





Thr Arg Asn Gly Gly Thr Phe Glu Lys Gln Ile Gly Glu Val Lys Pro 

            100                 105                 110         





Arg Thr Thr Pro Ala Ala Gly Gly Met Asp Glu Ser Val Val Leu Glu 

        115                 120                 125             





Pro Glu Ala Thr Gly Glu Ser Ser Ser Leu Glu Pro Thr Pro Ser Ser 

    130                 135                 140                 





Gln Glu Ala Gln Arg Ala Leu Gly Thr Ser Pro Glu Leu Pro Thr Gly 

145                 150                 155                 160 





Val Thr Gly Ser Ser Gly Thr Arg Leu Pro Pro Thr Pro Lys Ala Gln 

                165                 170                 175     





Asp Gly Gly Pro Val Gly Thr Glu Leu Phe Arg Val Pro Pro Val Ser 

            180                 185                 190         





Thr Ala Ala Thr Trp Gln Ser Ser Ala Pro His Gln Pro Gly Pro Ser 

        195                 200                 205             





Leu Trp Ala Glu Ala Lys Thr Ser Glu Ala Pro Ser Thr Gln Asp Pro 

    210                 215                 220                 





Ser Thr Gln Ala Ser Thr Ala Ser Ser Pro Ala Pro Glu Glu Asn Ala 

225                 230                 235                 240 





Pro Ser Glu Gly Gln Arg Val Trp Gly Gln Gly Gln Ser Pro Arg Pro 

                245                 250                 255     





Glu Asn Ser Leu Glu Arg Glu Glu Met Gly Pro Val Pro Ala His Thr 

            260                 265                 270         





Asp Ala Phe Gln Asp Trp Gly Pro Gly Ser Met Ala His Val Ser Val 

        275                 280                 285             





Val Pro Val Ser Ser Glu Gly Thr Pro Ser Arg Glu Pro Val Ala Ser 

    290                 295                 300                 





Gly Ser Trp Thr Pro Lys Ala Glu Glu Pro Ile His Ala Thr Met Asp 

305                 310                 315                 320 





Pro Gln Arg Leu Gly Val Leu Ile Thr Pro Val Pro Asp Ala Gln Ala 

                325                 330                 335     





Ala Thr Arg Arg Gln Ala Val Gly Leu Leu Ala Phe Leu Gly Leu Leu 

            340                 345                 350         





Phe Cys Leu Gly Val Ala Met Phe Thr Tyr Gln Ser Leu Gln Gly Cys 

        355                 360                 365             





Pro Arg Lys Met Ala Gly Glu Met Ala Glu Gly Leu Arg Tyr Ile Pro 

    370                 375                 380                 





Arg Ser Cys Gly Ser Asn Ser Tyr Val Leu Val Pro Val 

385                 390                 395         





<210>  69

<211>  2158

<212>  DNA

<213>  Homo sapiens



<400>  69

attcataaaa cgcttgttat aaaagcagtg gctgcggcgc ctcgtactcc aaccgcatct       60



gcagcgagca tctgagaagc caagactgag ccggcggccg cggcgcagcg aacgagcagt      120



gaccgtgctc ctacccagct ctgctccaca gcgcccacct gtctccgccc ctcggcccct      180



cgcccggctt tgcctaaccg ccacgatgat gttctcgggc ttcaacgcag actacgaggc      240



gtcatcctcc cgctgcagca gcgcgtcccc ggccggggat agcctctctt actaccactc      300



acccgcagac tccttctcca gcatgggctc gcctgtcaac gcgcaggact tctgcacgga      360



cctggccgtc tccagtgcca acttcattcc cacggtcact gccatctcga ccagtccgga      420



cctgcagtgg ctggtgcagc ccgccctcgt ctcctccgtg gccccatcgc agaccagagc      480



ccctcaccct ttcggagtcc ccgccccctc cgctggggct tactccaggg ctggcgttgt      540



gaagaccatg acaggaggcc gagcgcagag cattggcagg aggggcaagg tggaacagtt      600



atctccagaa gaagaagaga aaaggagaat ccgaagggaa aggaataaga tggctgcagc      660



caaatgccgc aaccggagga gggagctgac tgatacactc caagcggaga cagaccaact      720



agaagatgag aagtctgctt tgcagaccga gattgccaac ctgctgaagg agaaggaaaa      780



actagagttc atcctggcag ctcaccgacc tgcctgcaag atccctgatg acctgggctt      840



cccagaagag atgtctgtgg cttcccttga tctgactggg ggcctgccag aggttgccac      900



cccggagtct gaggaggcct tcaccctgcc tctcctcaat gaccctgagc ccaagccctc      960



agtggaacct gtcaagagca tcagcagcat ggagctgaag accgagccct ttgatgactt     1020



cctgttccca gcatcatcca ggcccagtgg ctctgagaca gcccgctccg tgccagacat     1080



ggacctatct gggtccttct atgcagcaga ctgggagcct ctgcacagtg gctccctggg     1140



gatggggccc atggccacag agctggagcc cctgtgcact ccggtggtca cctgtactcc     1200



cagctgcact gcttacacgt cttccttcgt cttcacctac cccgaggctg actccttccc     1260



cagctgtgca gctgcccacc gcaagggcag cagcagcaat gagccttcct ctgactcgct     1320



cagctcaccc acgctgctgg ccctgtgagg gggcagggaa ggggaggcag ccggcaccca     1380



caagtgccac tgcccgagct ggtgcattac agagaggaga aacacatctt ccctagaggg     1440



ttcctgtaga cctagggagg accttatctg tgcgtgaaac acaccaggct gtgggcctca     1500



aggacttgaa agcatccatg tgtggactca agtccttacc tcttccggag atgtagcaaa     1560



acgcatggag tgtgtattgt tcccagtgac acttcagaga gctggtagtt agtagcatgt     1620



tgagccaggc ctgggtctgt gtctcttttc tctttctcct tagtcttctc atagcattaa     1680



ctaatctatt gggttcatta ttggaattaa cctggtgctg gatattttca aattgtatct     1740



agtgcagctg attttaacaa taactactgt gttcctggca atagtgtgtt ctgattagaa     1800



atgaccaata ttatactaag aaaagatacg actttatttt ctggtagata gaaataaata     1860



gctatatcca tgtactgtag tttttcttca acatcaatgt tcattgtaat gttactgatc     1920



atgcattgtt gaggtggtct gaatgttctg acattaacag ttttccatga aaacgtttta     1980



ttgtgttttt aatttattta ttaagatgga ttctcagata tttatatttt tattttattt     2040



ttttctacct tgaggtcttt tgacatgtgg aaagtgaatt tgaatgaaaa atttaagcat     2100



tgtttgctta ttgttccaag acattgtcaa taaaagcatt taagttgaat gcgaccaa       2158





<210>  70

<211>  380

<212>  PRT

<213>  Homo sapiens



<400>  70



Met Met Phe Ser Gly Phe Asn Ala Asp Tyr Glu Ala Ser Ser Ser Arg 

1               5                   10                  15      





Cys Ser Ser Ala Ser Pro Ala Gly Asp Ser Leu Ser Tyr Tyr His Ser 

            20                  25                  30          





Pro Ala Asp Ser Phe Ser Ser Met Gly Ser Pro Val Asn Ala Gln Asp 

        35                  40                  45              





Phe Cys Thr Asp Leu Ala Val Ser Ser Ala Asn Phe Ile Pro Thr Val 

    50                  55                  60                  





Thr Ala Ile Ser Thr Ser Pro Asp Leu Gln Trp Leu Val Gln Pro Ala 

65                  70                  75                  80  





Leu Val Ser Ser Val Ala Pro Ser Gln Thr Arg Ala Pro His Pro Phe 

                85                  90                  95      





Gly Val Pro Ala Pro Ser Ala Gly Ala Tyr Ser Arg Ala Gly Val Val 

            100                 105                 110         





Lys Thr Met Thr Gly Gly Arg Ala Gln Ser Ile Gly Arg Arg Gly Lys 

        115                 120                 125             





Val Glu Gln Leu Ser Pro Glu Glu Glu Glu Lys Arg Arg Ile Arg Arg 

    130                 135                 140                 





Glu Arg Asn Lys Met Ala Ala Ala Lys Cys Arg Asn Arg Arg Arg Glu 

145                 150                 155                 160 





Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys 

                165                 170                 175     





Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys 

            180                 185                 190         





Leu Glu Phe Ile Leu Ala Ala His Arg Pro Ala Cys Lys Ile Pro Asp 

        195                 200                 205             





Asp Leu Gly Phe Pro Glu Glu Met Ser Val Ala Ser Leu Asp Leu Thr 

    210                 215                 220                 





Gly Gly Leu Pro Glu Val Ala Thr Pro Glu Ser Glu Glu Ala Phe Thr 

225                 230                 235                 240 





Leu Pro Leu Leu Asn Asp Pro Glu Pro Lys Pro Ser Val Glu Pro Val 

                245                 250                 255     





Lys Ser Ile Ser Ser Met Glu Leu Lys Thr Glu Pro Phe Asp Asp Phe 

            260                 265                 270         





Leu Phe Pro Ala Ser Ser Arg Pro Ser Gly Ser Glu Thr Ala Arg Ser 

        275                 280                 285             





Val Pro Asp Met Asp Leu Ser Gly Ser Phe Tyr Ala Ala Asp Trp Glu 

    290                 295                 300                 





Pro Leu His Ser Gly Ser Leu Gly Met Gly Pro Met Ala Thr Glu Leu 

305                 310                 315                 320 





Glu Pro Leu Cys Thr Pro Val Val Thr Cys Thr Pro Ser Cys Thr Ala 

                325                 330                 335     





Tyr Thr Ser Ser Phe Val Phe Thr Tyr Pro Glu Ala Asp Ser Phe Pro 

            340                 345                 350         





Ser Cys Ala Ala Ala His Arg Lys Gly Ser Ser Ser Asn Glu Pro Ser 

        355                 360                 365             





Ser Asp Ser Leu Ser Ser Pro Thr Leu Leu Ala Leu 

    370                 375                 380 





<210>  71

<211>  4326

<212>  DNA

<213>  Homo sapiens



<400>  71

gctgagcgcg gagccgcccg gtgattggtg ggggcggaag ggggccgggc gccagcgctg       60



ccttttctcc tgccgggtag tttcgctttc ctgcgcagag tctgcggagg ggctcggctg      120



caccgggggg atcgcgcctg gcagacccca gaccgagcag aggcgaccca gcgcgctcgg      180



gagaggctgc accgccgcgc ccccgcctag cccttccgga tcctgcgcgc agaaaagttt      240



catttgctgt atgccatcct cgagagctgt ctaggttaac gttcgcactc tgtgtatata      300



acctcgacag tcttggcacc taacgtgctg tgcgtagctg ctcctttggt tgaatcccca      360



ggcccttgtt ggggcacaag gtggcaggat gtctcagtgg tacgaacttc agcagcttga      420



ctcaaaattc ctggagcagg ttcaccagct ttatgatgac agttttccca tggaaatcag      480



acagtacctg gcacagtggt tagaaaagca agactgggag cacgctgcca atgatgtttc      540



atttgccacc atccgttttc atgacctcct gtcacagctg gatgatcaat atagtcgctt      600



ttctttggag aataacttct tgctacagca taacataagg aaaagcaagc gtaatcttca      660



ggataatttt caggaagacc caatccagat gtctatgatc atttacagct gtctgaagga      720



agaaaggaaa attctggaaa acgcccagag atttaatcag gctcagtcgg ggaatattca      780



gagcacagtg atgttagaca aacagaaaga gcttgacagt aaagtcagaa atgtgaagga      840



caaggttatg tgtatagagc atgaaatcaa gagcctggaa gatttacaag atgaatatga      900



cttcaaatgc aaaaccttgc agaacagaga acacgagacc aatggtgtgg caaagagtga      960



tcagaaacaa gaacagctgt tactcaagaa gatgtattta atgcttgaca ataagagaaa     1020



ggaagtagtt cacaaaataa tagagttgct gaatgtcact gaacttaccc agaatgccct     1080



gattaatgat gaactagtgg agtggaagcg gagacagcag agcgcctgta ttggggggcc     1140



gcccaatgct tgcttggatc agctgcagaa ctggttcact atagttgcgg agagtctgca     1200



gcaagttcgg cagcagctta aaaagttgga ggaattggaa cagaaataca cctacgaaca     1260



tgaccctatc acaaaaaaca aacaagtgtt atgggaccgc accttcagtc ttttccagca     1320



gctcattcag agctcgtttg tggtggaaag acagccctgc atgccaacgc accctcagag     1380



gccgctggtc ttgaagacag gggtccagtt cactgtgaag ttgagactgt tggtgaaatt     1440



gcaagagctg aattataatt tgaaagtcaa agtcttattt gataaagatg tgaatgagag     1500



aaatacagta aaaggattta ggaagttcaa cattttgggc acgcacacaa aagtgatgaa     1560



catggaggag tccaccaatg gcagtctggc ggctgaattt cggcacctgc aattgaaaga     1620



acagaaaaat gctggcacca gaacgaatga gggtcctctc atcgttactg aagagcttca     1680



ctcccttagt tttgaaaccc aattgtgcca gcctggtttg gtaattgacc tcgagacgac     1740



ctctctgccc gttgtggtga tctccaacgt cagccagctc ccgagcggtt gggcctccat     1800



cctttggtac aacatgctgg tggcggaacc caggaatctg tccttcttcc tgactccacc     1860



atgtgcacga tgggctcagc tttcagaagt gctgagttgg cagttttctt ctgtcaccaa     1920



aagaggtctc aatgtggacc agctgaacat gttgggagag aagcttcttg gtcctaacgc     1980



cagccccgat ggtctcattc cgtggacgag gttttgtaag gaaaatataa atgataaaaa     2040



ttttcccttc tggctttgga ttgaaagcat cctagaactc attaaaaaac acctgctccc     2100



tctctggaat gatgggtgca tcatgggctt catcagcaag gagcgagagc gtgccctgtt     2160



gaaggaccag cagccgggga ccttcctgct gcggttcagt gagagctccc gggaaggggc     2220



catcacattc acatgggtgg agcggtccca gaacggaggc gaacctgact tccatgcggt     2280



tgaaccctac acgaagaaag aactttctgc tgttactttc cctgacatca ttcgcaatta     2340



caaagtcatg gctgctgaga atattcctga gaatcccctg aagtatctgt atccaaatat     2400



tgacaaagac catgcctttg gaaagtatta ctccaggcca aaggaagcac cagagccaat     2460



ggaacttgat ggccctaaag gaactggata tatcaagact gagttgattt ctgtgtctga     2520



agttcaccct tctagacttc agaccacaga caacctgctc cccatgtctc ctgaggagtt     2580



tgacgaggtg tctcggatag tgggctctgt agaattcgac agtatgatga acacagtata     2640



gagcatgaat ttttttcatc ttctctggcg acagttttcc ttctcatctg tgattccctc     2700



ctgctactct gttccttcac atcctgtgtt tctagggaaa tgaaagaaag gccagcaaat     2760



tcgctgcaac ctgttgatag caagtgaatt tttctctaac tcagaaacat cagttactct     2820



gaagggcatc atgcatctta ctgaaggtaa aattgaaagg cattctctga agagtgggtt     2880



tcacaagtga aaaacatcca gatacaccca aagtatcagg acgagaatga gggtcctttg     2940



ggaaaggaga agttaagcaa catctagcaa atgttatgca taaagtcagt gcccaactgt     3000



tataggttgt tggataaatc agtggttatt tagggaactg cttgacgtag gaacggtaaa     3060



tttctgtggg agaattctta catgttttct ttgctttaag tgtaactggc agttttccat     3120



tggtttacct gtgaaatagt tcaaagccaa gtttatatac aattatatca gtcctctttc     3180



aaaggtagcc atcatggatc tggtaggggg aaaatgtgta ttttattaca tctttcacat     3240



tggctattta aagacaaaga caaattctgt ttcttgagaa gagaatatta gctttactgt     3300



ttgttatggc ttaatgacac tagctaatat caatagaagg atgtacattt ccaaattcac     3360



aagttgtgtt tgatatccaa agctgaatac attctgcttt catcttggtc acatacaatt     3420



atttttacag ttctcccaag ggagttaggc tattcacaac cactcattca aaagttgaaa     3480



ttaaccatag atgtagataa actcagaaat ttaattcatg tttcttaaat gggctacttt     3540



gtcctttttg ttattagggt ggtatttagt ctattagcca caaaattggg aaaggagtag     3600



aaaaagcagt aactgacaac ttgaataata caccagagat aatatgagaa tcagatcatt     3660



tcaaaactca tttcctatgt aactgcattg agaactgcat atgtttcgct gatatatgtg     3720



tttttcacat ttgcgaatgg ttccattctc tctcctgtac tttttccaga cacttttttg     3780



agtggatgat gtttcgtgaa gtatactgta tttttacctt tttccttcct tatcactgac     3840



acaaaaagta gattaagaga tgggtttgac aaggttcttc ccttttacat actgctgtct     3900



atgtggctgt atcttgtttt tccactactg ctaccacaac tatattatca tgcaaatgct     3960



gtattcttct ttggtggaga taaagatttc ttgagttttg ttttaaaatt aaagctaaag     4020



tatctgtatt gcattaaata taatatgcac acagtgcttt ccgtggcact gcatacaatc     4080



tgaggcctcc tctctcagtt tttatataga tggcgagaac ctaagtttca gttgatttta     4140



caattgaaat gactaaaaaa caaagaagac aacattaaaa caatattgtt tctaattgct     4200



gaggtttagc tgtcagttct ttttgccctt tgggaattcg gcatggtttc attttactgc     4260



actagccaag agactttact tttaagaagt attaaaattc taaaattcaa aaaaaaaaaa     4320



aaaaaa                                                                4326





<210>  72

<211>  750

<212>  PRT

<213>  Homo sapiens



<400>  72



Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 

1               5                   10                  15      





Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 

            20                  25                  30          





Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 

        35                  40                  45              





Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 

    50                  55                  60                  





Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 

65                  70                  75                  80  





His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 

                85                  90                  95      





Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 

            100                 105                 110         





Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 

        115                 120                 125             





Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 

    130                 135                 140                 





Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 

145                 150                 155                 160 





Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 

                165                 170                 175     





Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 

            180                 185                 190         





Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 

        195                 200                 205             





Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 

    210                 215                 220                 





Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 

225                 230                 235                 240 





Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 

                245                 250                 255     





Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 

            260                 265                 270         





Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 

        275                 280                 285             





Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 

    290                 295                 300                 





Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 

305                 310                 315                 320 





Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 

                325                 330                 335     





Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 

            340                 345                 350         





Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 

        355                 360                 365             





Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 

    370                 375                 380                 





Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 

385                 390                 395                 400 





Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 

                405                 410                 415     





Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 

            420                 425                 430         





Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 

        435                 440                 445             





Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 

    450                 455                 460                 





Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 

465                 470                 475                 480 





Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 

                485                 490                 495     





Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 

            500                 505                 510         





Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 

        515                 520                 525             





Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 

    530                 535                 540                 





Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 

545                 550                 555                 560 





Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 

                565                 570                 575     





Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 

            580                 585                 590         





Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 

        595                 600                 605             





Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 

    610                 615                 620                 





Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 

625                 630                 635                 640 





Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 

                645                 650                 655     





Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 

            660                 665                 670         





Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 

        675                 680                 685             





Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 

    690                 695                 700                 





Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr 

705                 710                 715                 720 





Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg 

                725                 730                 735     





Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val 

            740                 745                 750 





<210>  73

<211>  2798

<212>  DNA

<213>  Homo sapiens



<400>  73

gctgagcgcg gagccgcccg gtgattggtg ggggcggaag ggggccgggc gccagcgctg       60



ccttttctcc tgccgggtag tttcgctttc ctgcgcagag tctgcggagg ggctcggctg      120



caccgggggg atcgcgcctg gcagacccca gaccgagcag aggcgaccca gcgcgctcgg      180



gagaggctgc accgccgcgc ccccgcctag cccttccgga tcctgcgcgc agaaaagttt      240



catttgctgt atgccatcct cgagagctgt ctaggttaac gttcgcactc tgtgtatata      300



acctcgacag tcttggcacc taacgtgctg tgcgtagctg ctcctttggt tgaatcccca      360



ggcccttgtt ggggcacaag gtggcaggat gtctcagtgg tacgaacttc agcagcttga      420



ctcaaaattc ctggagcagg ttcaccagct ttatgatgac agttttccca tggaaatcag      480



acagtacctg gcacagtggt tagaaaagca agactgggag cacgctgcca atgatgtttc      540



atttgccacc atccgttttc atgacctcct gtcacagctg gatgatcaat atagtcgctt      600



ttctttggag aataacttct tgctacagca taacataagg aaaagcaagc gtaatcttca      660



ggataatttt caggaagacc caatccagat gtctatgatc atttacagct gtctgaagga      720



agaaaggaaa attctggaaa acgcccagag atttaatcag gctcagtcgg ggaatattca      780



gagcacagtg atgttagaca aacagaaaga gcttgacagt aaagtcagaa atgtgaagga      840



caaggttatg tgtatagagc atgaaatcaa gagcctggaa gatttacaag atgaatatga      900



cttcaaatgc aaaaccttgc agaacagaga acacgagacc aatggtgtgg caaagagtga      960



tcagaaacaa gaacagctgt tactcaagaa gatgtattta atgcttgaca ataagagaaa     1020



ggaagtagtt cacaaaataa tagagttgct gaatgtcact gaacttaccc agaatgccct     1080



gattaatgat gaactagtgg agtggaagcg gagacagcag agcgcctgta ttggggggcc     1140



gcccaatgct tgcttggatc agctgcagaa ctggttcact atagttgcgg agagtctgca     1200



gcaagttcgg cagcagctta aaaagttgga ggaattggaa cagaaataca cctacgaaca     1260



tgaccctatc acaaaaaaca aacaagtgtt atgggaccgc accttcagtc ttttccagca     1320



gctcattcag agctcgtttg tggtggaaag acagccctgc atgccaacgc accctcagag     1380



gccgctggtc ttgaagacag gggtccagtt cactgtgaag ttgagactgt tggtgaaatt     1440



gcaagagctg aattataatt tgaaagtcaa agtcttattt gataaagatg tgaatgagag     1500



aaatacagta aaaggattta ggaagttcaa cattttgggc acgcacacaa aagtgatgaa     1560



catggaggag tccaccaatg gcagtctggc ggctgaattt cggcacctgc aattgaaaga     1620



acagaaaaat gctggcacca gaacgaatga gggtcctctc atcgttactg aagagcttca     1680



ctcccttagt tttgaaaccc aattgtgcca gcctggtttg gtaattgacc tcgagacgac     1740



ctctctgccc gttgtggtga tctccaacgt cagccagctc ccgagcggtt gggcctccat     1800



cctttggtac aacatgctgg tggcggaacc caggaatctg tccttcttcc tgactccacc     1860



atgtgcacga tgggctcagc tttcagaagt gctgagttgg cagttttctt ctgtcaccaa     1920



aagaggtctc aatgtggacc agctgaacat gttgggagag aagcttcttg gtcctaacgc     1980



cagccccgat ggtctcattc cgtggacgag gttttgtaag gaaaatataa atgataaaaa     2040



ttttcccttc tggctttgga ttgaaagcat cctagaactc attaaaaaac acctgctccc     2100



tctctggaat gatgggtgca tcatgggctt catcagcaag gagcgagagc gtgccctgtt     2160



gaaggaccag cagccgggga ccttcctgct gcggttcagt gagagctccc gggaaggggc     2220



catcacattc acatgggtgg agcggtccca gaacggaggc gaacctgact tccatgcggt     2280



tgaaccctac acgaagaaag aactttctgc tgttactttc cctgacatca ttcgcaatta     2340



caaagtcatg gctgctgaga atattcctga gaatcccctg aagtatctgt atccaaatat     2400



tgacaaagac catgcctttg gaaagtatta ctccaggcca aaggaagcac cagagccaat     2460



ggaacttgat ggccctaaag gaactggata tatcaagact gagttgattt ctgtgtctga     2520



agtgtaagtg aacacagaag agtgacatgt ttacaaacct caagccagcc ttgctcctgg     2580



ctggggcctg ttgaagatgc ttgtatttta cttttccatt gtaattgcta tcgccatcac     2640



agctgaactt gttgagatcc ccgtgttact gcctatcagc attttactac tttaaaaaaa     2700



aaaaaaaagc caaaaaccaa atttgtattt aaggtatata aattttccca aaactgatac     2760



cctttgaaaa agtataaata aaatgagcaa aagttgat                             2798





<210>  74

<211>  712

<212>  PRT

<213>  Homo sapiens



<400>  74



Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 

1               5                   10                  15      





Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 

            20                  25                  30          





Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 

        35                  40                  45              





Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 

    50                  55                  60                  





Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 

65                  70                  75                  80  





His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 

                85                  90                  95      





Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 

            100                 105                 110         





Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 

        115                 120                 125             





Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 

    130                 135                 140                 





Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 

145                 150                 155                 160 





Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 

                165                 170                 175     





Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 

            180                 185                 190         





Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 

        195                 200                 205             





Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 

    210                 215                 220                 





Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 

225                 230                 235                 240 





Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 

                245                 250                 255     





Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 

            260                 265                 270         





Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 

        275                 280                 285             





Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 

    290                 295                 300                 





Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 

305                 310                 315                 320 





Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 

                325                 330                 335     





Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 

            340                 345                 350         





Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 

        355                 360                 365             





Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 

    370                 375                 380                 





Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 

385                 390                 395                 400 





Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 

                405                 410                 415     





Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 

            420                 425                 430         





Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 

        435                 440                 445             





Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 

    450                 455                 460                 





Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 

465                 470                 475                 480 





Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 

                485                 490                 495     





Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 

            500                 505                 510         





Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 

        515                 520                 525             





Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 

    530                 535                 540                 





Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 

545                 550                 555                 560 





Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 

                565                 570                 575     





Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 

            580                 585                 590         





Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 

        595                 600                 605             





Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 

    610                 615                 620                 





Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 

625                 630                 635                 640 





Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 

                645                 650                 655     





Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 

            660                 665                 670         





Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 

        675                 680                 685             





Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 

    690                 695                 700                 





Glu Leu Ile Ser Val Ser Glu Val 

705                 710         





<210>  75

<211>  4090

<212>  DNA

<213>  Homo sapiens



<400>  75

gtgagagagt gagcgagaca gaaagagaga gaagtgcacc agcgagccgg ggcaggaaga       60



ggaggtttcg ccaccggagc ggcccggcga cgcgctgaca gcttcccctg cccttcccgt      120



cggtcgggcc gccagccgcc gcagccctcg gcctgcacgc agccaccggc cccgctcccg      180



gagcccagcg ccgccgaggc cgcagccgcc cggccagtaa ggcggcgccg ccgcccggcc      240



accgcgcgcc ctgcgcttcc ctccgcccgc gctgcggcca tggcgcggcg ctgactggcc      300



tggcccggcc ccgccgcgct cccgctcgcc ccgacccgca ctcgggcccg cccgggctcc      360



ggcctgccgc cgcctcttcc ttctccagcc ggcaggcccg cgccgcttag gagggagagc      420



ccacccgcgc caggaggccg aacgcggact cgccacccgg cttcagaatg gcagaagatg      480



atccatattt gggaaggcct gaacaaatgt ttcatttgga tccttctttg actcatacaa      540



tatttaatcc agaagtattt caaccacaga tggcactgcc aacagatggc ccataccttc      600



aaatattaga gcaacctaaa cagagaggat ttcgtttccg ttatgtatgt gaaggcccat      660



cccatggtgg actacctggt gcctctagtg aaaagaacaa gaagtcttac cctcaggtca      720



aaatctgcaa ctatgtggga ccagcaaagg ttattgttca gttggtcaca aatggaaaaa      780



atatccacct gcatgcccac agcctggtgg gaaaacactg tgaggatggg atctgcactg      840



taactgctgg acccaaggac atggtggtcg gcttcgcaaa cctgggtata cttcatgtga      900



caaagaaaaa agtatttgaa acactggaag cacgaatgac agaggcgtgt ataaggggct      960



ataatcctgg actcttggtg caccctgacc ttgcctattt gcaagcagaa ggtggagggg     1020



accggcagct gggagatcgg gaaaaagagc taatccgcca agcagctctg cagcagacca     1080



aggagatgga cctcagcgtg gtgcggctca tgtttacagc ttttcttccg gatagcactg     1140



gcagcttcac aaggcgcctg gaacccgtgg tatcagacgc catctatgac agtaaagccc     1200



ccaatgcatc caacttgaaa attgtaagaa tggacaggac agctggatgt gtgactggag     1260



gggaggaaat ttatcttctt tgtgacaaag ttcagaaaga tgacatccag attcgatttt     1320



atgaagagga agaaaatggt ggagtctggg aaggatttgg agatttttcc cccacagatg     1380



ttcatagaca atttgccatt gtcttcaaaa ctccaaagta taaagatatt aatattacaa     1440



aaccagcctc tgtgtttgtc cagcttcgga ggaaatctga cttggaaact agtgaaccaa     1500



aacctttcct ctactatcct gaaatcaaag ataaagaaga agtgcagagg aaacgtcaga     1560



agctcatgcc caatttttcg gatagtttcg gcggtggtag tggtgctgga gctggaggcg     1620



gaggcatgtt tggtagtggc ggtggaggag ggggcactgg aagtacaggt ccagggtata     1680



gcttcccaca ctatggattt cctacttatg gtgggattac tttccatcct ggaactacta     1740



aatctaatgc tgggatgaag catggaacca tggacactga atctaaaaag gaccctgaag     1800



gttgtgacaa aagtgatgac aaaaacactg taaacctctt tgggaaagtt attgaaacca     1860



cagagcaaga tcaggagccc agcgaggcca ccgttgggaa tggtgaggtc actctaacgt     1920



atgcaacagg aacaaaagaa gagagtgctg gagttcagga taacctcttt ctagagaagg     1980



ctatgcagct tgcaaagagg catgccaatg cccttttcga ctacgcggtg acaggagacg     2040



tgaagatgct gctggccgtc cagcgccatc tcactgctgt gcaggatgag aatggggaca     2100



gtgtcttaca cttagcaatc atccaccttc attctcaact tgtgagggat ctactagaag     2160



tcacatctgg tttgatttct gatgacatta tcaacatgag aaatgatctg taccagacgc     2220



ccttgcactt ggcagtgatc actaagcagg aagatgtggt ggaggatttg ctgagggctg     2280



gggccgacct gagccttctg gaccgcttgg gtaactctgt tttgcaccta gctgccaaag     2340



aaggacatga taaagttctc agtatcttac tcaagcacaa aaaggcagca ctacttcttg     2400



accaccccaa cggggacggt ctgaatgcca ttcatctagc catgatgagc aatagcctgc     2460



catgtttgct gctgctggtg gccgctgggg ctgacgtcaa tgctcaggag cagaagtccg     2520



ggcgcacagc actgcacctg gctgtggagc acgacaacat ctcattggca ggctgcctgc     2580



tcctggaggg tgatgcccat gtggacagta ctacctacga tggaaccaca cccctgcata     2640



tagcagctgg gagagggtcc accaggctgg cagctcttct caaagcagca ggagcagatc     2700



ccctggtgga gaactttgag cctctctatg acctggatga ctcttgggaa aatgcaggag     2760



aggatgaagg agttgtgcct ggaaccacgc ctctagatat ggccaccagc tggcaggtat     2820



ttgacatatt aaatgggaaa ccatatgagc cagagtttac atctgatgat ttactagcac     2880



aaggagacat gaaacagctg gctgaagatg tgaagctgca gctgtataag ttactagaaa     2940



ttcctgatcc agacaaaaac tgggctactc tggcgcagaa attaggtctg gggatactta     3000



ataatgcctt ccggctgagt cctgctcctt ccaaaacact tatggacaac tatgaggtct     3060



ctgggggtac agtcagagag ctggtggagg ccctgagaca aatgggctac accgaagcaa     3120



ttgaagtgat ccaggcagcc tccagcccag tgaagaccac ctctcaggcc cactcgctgc     3180



ctctctcgcc tgcctccaca aggcagcaaa tagacgagct ccgagacagt gacagtgtct     3240



gcgacagcgg cgtggagaca tccttccgca aactcagctt taccgagtct ctgaccagtg     3300



gtgcctcact gctaactctc aacaaaatgc cccatgatta tgggcaggaa ggacctctag     3360



aaggcaaaat ttagcctgct gacaatttcc cacaccgtgt aaaccaaagc cctaaaattc     3420



cactgcgttg tccacaagac agaagctgaa gtgcatccaa aggtgctcag agagccggcc     3480



cgcctgaatc attctcgatt taactcgaga ccttttcaac ttggcttcct ttcttggttc     3540



ataaatgaat tttagtttgg ttcacttaca gatagtatct agcaatcaca acactggctg     3600



agcggatgca tctggggatg aggttgctta ctaagctttg ccagctgctg ctggatcaca     3660



gctgctttct gttgtcattg ctgttgtccc tctgctacgt tcctattgtc attaaaggta     3720



tcacggtcgc cacctggcat tccttctgac cacagcatca ttttgcattc aaattaaggg     3780



ttaagaaaag agatatttta aaatgagagt cacttgatgt gccattttaa aaaaaaaggc     3840



atattgcttt ttctaatgtg gttatttctc tgatttgcaa aaaaaaaaaa aaaaaaaata     3900



cttgtcaata tttaaacatg gttacaatca ttgctgaaaa tggtattttc ccccttttct     3960



gcattttgct attgtaaata tgttttttag atcaaatact ttaaaggaaa aaatgttgga     4020



tttataaatg ctatttttta ttttactttt ataataaaag gaaaagcaaa ttgatgacct     4080



caaaaaaaaa                                                            4090





<210>  76

<211>  968

<212>  PRT

<213>  Homo sapiens



<400>  76



Met Ala Glu Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His 

1               5                   10                  15      





Leu Asp Pro Ser Leu Thr His Thr Ile Phe Asn Pro Glu Val Phe Gln 

            20                  25                  30          





Pro Gln Met Ala Leu Pro Thr Asp Gly Pro Tyr Leu Gln Ile Leu Glu 

        35                  40                  45              





Gln Pro Lys Gln Arg Gly Phe Arg Phe Arg Tyr Val Cys Glu Gly Pro 

    50                  55                  60                  





Ser His Gly Gly Leu Pro Gly Ala Ser Ser Glu Lys Asn Lys Lys Ser 

65                  70                  75                  80  





Tyr Pro Gln Val Lys Ile Cys Asn Tyr Val Gly Pro Ala Lys Val Ile 

                85                  90                  95      





Val Gln Leu Val Thr Asn Gly Lys Asn Ile His Leu His Ala His Ser 

            100                 105                 110         





Leu Val Gly Lys His Cys Glu Asp Gly Ile Cys Thr Val Thr Ala Gly 

        115                 120                 125             





Pro Lys Asp Met Val Val Gly Phe Ala Asn Leu Gly Ile Leu His Val 

    130                 135                 140                 





Thr Lys Lys Lys Val Phe Glu Thr Leu Glu Ala Arg Met Thr Glu Ala 

145                 150                 155                 160 





Cys Ile Arg Gly Tyr Asn Pro Gly Leu Leu Val His Pro Asp Leu Ala 

                165                 170                 175     





Tyr Leu Gln Ala Glu Gly Gly Gly Asp Arg Gln Leu Gly Asp Arg Glu 

            180                 185                 190         





Lys Glu Leu Ile Arg Gln Ala Ala Leu Gln Gln Thr Lys Glu Met Asp 

        195                 200                 205             





Leu Ser Val Val Arg Leu Met Phe Thr Ala Phe Leu Pro Asp Ser Thr 

    210                 215                 220                 





Gly Ser Phe Thr Arg Arg Leu Glu Pro Val Val Ser Asp Ala Ile Tyr 

225                 230                 235                 240 





Asp Ser Lys Ala Pro Asn Ala Ser Asn Leu Lys Ile Val Arg Met Asp 

                245                 250                 255     





Arg Thr Ala Gly Cys Val Thr Gly Gly Glu Glu Ile Tyr Leu Leu Cys 

            260                 265                 270         





Asp Lys Val Gln Lys Asp Asp Ile Gln Ile Arg Phe Tyr Glu Glu Glu 

        275                 280                 285             





Glu Asn Gly Gly Val Trp Glu Gly Phe Gly Asp Phe Ser Pro Thr Asp 

    290                 295                 300                 





Val His Arg Gln Phe Ala Ile Val Phe Lys Thr Pro Lys Tyr Lys Asp 

305                 310                 315                 320 





Ile Asn Ile Thr Lys Pro Ala Ser Val Phe Val Gln Leu Arg Arg Lys 

                325                 330                 335     





Ser Asp Leu Glu Thr Ser Glu Pro Lys Pro Phe Leu Tyr Tyr Pro Glu 

            340                 345                 350         





Ile Lys Asp Lys Glu Glu Val Gln Arg Lys Arg Gln Lys Leu Met Pro 

        355                 360                 365             





Asn Phe Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala Gly Ala Gly Gly 

    370                 375                 380                 





Gly Gly Met Phe Gly Ser Gly Gly Gly Gly Gly Gly Thr Gly Ser Thr 

385                 390                 395                 400 





Gly Pro Gly Tyr Ser Phe Pro His Tyr Gly Phe Pro Thr Tyr Gly Gly 

                405                 410                 415     





Ile Thr Phe His Pro Gly Thr Thr Lys Ser Asn Ala Gly Met Lys His 

            420                 425                 430         





Gly Thr Met Asp Thr Glu Ser Lys Lys Asp Pro Glu Gly Cys Asp Lys 

        435                 440                 445             





Ser Asp Asp Lys Asn Thr Val Asn Leu Phe Gly Lys Val Ile Glu Thr 

    450                 455                 460                 





Thr Glu Gln Asp Gln Glu Pro Ser Glu Ala Thr Val Gly Asn Gly Glu 

465                 470                 475                 480 





Val Thr Leu Thr Tyr Ala Thr Gly Thr Lys Glu Glu Ser Ala Gly Val 

                485                 490                 495     





Gln Asp Asn Leu Phe Leu Glu Lys Ala Met Gln Leu Ala Lys Arg His 

            500                 505                 510         





Ala Asn Ala Leu Phe Asp Tyr Ala Val Thr Gly Asp Val Lys Met Leu 

        515                 520                 525             





Leu Ala Val Gln Arg His Leu Thr Ala Val Gln Asp Glu Asn Gly Asp 

    530                 535                 540                 





Ser Val Leu His Leu Ala Ile Ile His Leu His Ser Gln Leu Val Arg 

545                 550                 555                 560 





Asp Leu Leu Glu Val Thr Ser Gly Leu Ile Ser Asp Asp Ile Ile Asn 

                565                 570                 575     





Met Arg Asn Asp Leu Tyr Gln Thr Pro Leu His Leu Ala Val Ile Thr 

            580                 585                 590         





Lys Gln Glu Asp Val Val Glu Asp Leu Leu Arg Ala Gly Ala Asp Leu 

        595                 600                 605             





Ser Leu Leu Asp Arg Leu Gly Asn Ser Val Leu His Leu Ala Ala Lys 

    610                 615                 620                 





Glu Gly His Asp Lys Val Leu Ser Ile Leu Leu Lys His Lys Lys Ala 

625                 630                 635                 640 





Ala Leu Leu Leu Asp His Pro Asn Gly Asp Gly Leu Asn Ala Ile His 

                645                 650                 655     





Leu Ala Met Met Ser Asn Ser Leu Pro Cys Leu Leu Leu Leu Val Ala 

            660                 665                 670         





Ala Gly Ala Asp Val Asn Ala Gln Glu Gln Lys Ser Gly Arg Thr Ala 

        675                 680                 685             





Leu His Leu Ala Val Glu His Asp Asn Ile Ser Leu Ala Gly Cys Leu 

    690                 695                 700                 





Leu Leu Glu Gly Asp Ala His Val Asp Ser Thr Thr Tyr Asp Gly Thr 

705                 710                 715                 720 





Thr Pro Leu His Ile Ala Ala Gly Arg Gly Ser Thr Arg Leu Ala Ala 

                725                 730                 735     





Leu Leu Lys Ala Ala Gly Ala Asp Pro Leu Val Glu Asn Phe Glu Pro 

            740                 745                 750         





Leu Tyr Asp Leu Asp Asp Ser Trp Glu Asn Ala Gly Glu Asp Glu Gly 

        755                 760                 765             





Val Val Pro Gly Thr Thr Pro Leu Asp Met Ala Thr Ser Trp Gln Val 

    770                 775                 780                 





Phe Asp Ile Leu Asn Gly Lys Pro Tyr Glu Pro Glu Phe Thr Ser Asp 

785                 790                 795                 800 





Asp Leu Leu Ala Gln Gly Asp Met Lys Gln Leu Ala Glu Asp Val Lys 

                805                 810                 815     





Leu Gln Leu Tyr Lys Leu Leu Glu Ile Pro Asp Pro Asp Lys Asn Trp 

            820                 825                 830         





Ala Thr Leu Ala Gln Lys Leu Gly Leu Gly Ile Leu Asn Asn Ala Phe 

        835                 840                 845             





Arg Leu Ser Pro Ala Pro Ser Lys Thr Leu Met Asp Asn Tyr Glu Val 

    850                 855                 860                 





Ser Gly Gly Thr Val Arg Glu Leu Val Glu Ala Leu Arg Gln Met Gly 

865                 870                 875                 880 





Tyr Thr Glu Ala Ile Glu Val Ile Gln Ala Ala Ser Ser Pro Val Lys 

                885                 890                 895     





Thr Thr Ser Gln Ala His Ser Leu Pro Leu Ser Pro Ala Ser Thr Arg 

            900                 905                 910         





Gln Gln Ile Asp Glu Leu Arg Asp Ser Asp Ser Val Cys Asp Ser Gly 

        915                 920                 925             





Val Glu Thr Ser Phe Arg Lys Leu Ser Phe Thr Glu Ser Leu Thr Ser 

    930                 935                 940                 





Gly Ala Ser Leu Leu Thr Leu Asn Lys Met Pro His Asp Tyr Gly Gln 

945                 950                 955                 960 





Glu Gly Pro Leu Glu Gly Lys Ile 

                965             





<210>  77

<211>  4093

<212>  DNA

<213>  Homo sapiens



<400>  77

gtgagagagt gagcgagaca gaaagagaga gaagtgcacc agcgagccgg ggcaggaaga       60



ggaggtttcg ccaccggagc ggcccggcga cgcgctgaca gcttcccctg cccttcccgt      120



cggtcgggcc gccagccgcc gcagccctcg gcctgcacgc agccaccggc cccgctcccg      180



gagcccagcg ccgccgaggc cgcagccgcc cggccagtaa ggcggcgccg ccgcccggcc      240



accgcgcgcc ctgcgcttcc ctccgcccgc gctgcggcca tggcgcggcg ctgactggcc      300



tggcccggcc ccgccgcgct cccgctcgcc ccgacccgca ctcgggcccg cccgggctcc      360



ggcctgccgc cgcctcttcc ttctccagcc ggcaggcccg cgccgcttag gagggagagc      420



ccacccgcgc caggaggccg aacgcggact cgccacccgg cttcagaatg gcagaagatg      480



atccatattt gggaaggcct gaacaaatgt ttcatttgga tccttctttg actcatacaa      540



tatttaatcc agaagtattt caaccacaga tggcactgcc aacagcagat ggcccatacc      600



ttcaaatatt agagcaacct aaacagagag gatttcgttt ccgttatgta tgtgaaggcc      660



catcccatgg tggactacct ggtgcctcta gtgaaaagaa caagaagtct taccctcagg      720



tcaaaatctg caactatgtg ggaccagcaa aggttattgt tcagttggtc acaaatggaa      780



aaaatatcca cctgcatgcc cacagcctgg tgggaaaaca ctgtgaggat gggatctgca      840



ctgtaactgc tggacccaag gacatggtgg tcggcttcgc aaacctgggt atacttcatg      900



tgacaaagaa aaaagtattt gaaacactgg aagcacgaat gacagaggcg tgtataaggg      960



gctataatcc tggactcttg gtgcaccctg accttgccta tttgcaagca gaaggtggag     1020



gggaccggca gctgggagat cgggaaaaag agctaatccg ccaagcagct ctgcagcaga     1080



ccaaggagat ggacctcagc gtggtgcggc tcatgtttac agcttttctt ccggatagca     1140



ctggcagctt cacaaggcgc ctggaacccg tggtatcaga cgccatctat gacagtaaag     1200



cccccaatgc atccaacttg aaaattgtaa gaatggacag gacagctgga tgtgtgactg     1260



gaggggagga aatttatctt ctttgtgaca aagttcagaa agatgacatc cagattcgat     1320



tttatgaaga ggaagaaaat ggtggagtct gggaaggatt tggagatttt tcccccacag     1380



atgttcatag acaatttgcc attgtcttca aaactccaaa gtataaagat attaatatta     1440



caaaaccagc ctctgtgttt gtccagcttc ggaggaaatc tgacttggaa actagtgaac     1500



caaaaccttt cctctactat cctgaaatca aagataaaga agaagtgcag aggaaacgtc     1560



agaagctcat gcccaatttt tcggatagtt tcggcggtgg tagtggtgct ggagctggag     1620



gcggaggcat gtttggtagt ggcggtggag gagggggcac tggaagtaca ggtccagggt     1680



atagcttccc acactatgga tttcctactt atggtgggat tactttccat cctggaacta     1740



ctaaatctaa tgctgggatg aagcatggaa ccatggacac tgaatctaaa aaggaccctg     1800



aaggttgtga caaaagtgat gacaaaaaca ctgtaaacct ctttgggaaa gttattgaaa     1860



ccacagagca agatcaggag cccagcgagg ccaccgttgg gaatggtgag gtcactctaa     1920



cgtatgcaac aggaacaaaa gaagagagtg ctggagttca ggataacctc tttctagaga     1980



aggctatgca gcttgcaaag aggcatgcca atgccctttt cgactacgcg gtgacaggag     2040



acgtgaagat gctgctggcc gtccagcgcc atctcactgc tgtgcaggat gagaatgggg     2100



acagtgtctt acacttagca atcatccacc ttcattctca acttgtgagg gatctactag     2160



aagtcacatc tggtttgatt tctgatgaca ttatcaacat gagaaatgat ctgtaccaga     2220



cgcccttgca cttggcagtg atcactaagc aggaagatgt ggtggaggat ttgctgaggg     2280



ctggggccga cctgagcctt ctggaccgct tgggtaactc tgttttgcac ctagctgcca     2340



aagaaggaca tgataaagtt ctcagtatct tactcaagca caaaaaggca gcactacttc     2400



ttgaccaccc caacggggac ggtctgaatg ccattcatct agccatgatg agcaatagcc     2460



tgccatgttt gctgctgctg gtggccgctg gggctgacgt caatgctcag gagcagaagt     2520



ccgggcgcac agcactgcac ctggctgtgg agcacgacaa catctcattg gcaggctgcc     2580



tgctcctgga gggtgatgcc catgtggaca gtactaccta cgatggaacc acacccctgc     2640



atatagcagc tgggagaggg tccaccaggc tggcagctct tctcaaagca gcaggagcag     2700



atcccctggt ggagaacttt gagcctctct atgacctgga tgactcttgg gaaaatgcag     2760



gagaggatga aggagttgtg cctggaacca cgcctctaga tatggccacc agctggcagg     2820



tatttgacat attaaatggg aaaccatatg agccagagtt tacatctgat gatttactag     2880



cacaaggaga catgaaacag ctggctgaag atgtgaagct gcagctgtat aagttactag     2940



aaattcctga tccagacaaa aactgggcta ctctggcgca gaaattaggt ctggggatac     3000



ttaataatgc cttccggctg agtcctgctc cttccaaaac acttatggac aactatgagg     3060



tctctggggg tacagtcaga gagctggtgg aggccctgag acaaatgggc tacaccgaag     3120



caattgaagt gatccaggca gcctccagcc cagtgaagac cacctctcag gcccactcgc     3180



tgcctctctc gcctgcctcc acaaggcagc aaatagacga gctccgagac agtgacagtg     3240



tctgcgacag cggcgtggag acatccttcc gcaaactcag ctttaccgag tctctgacca     3300



gtggtgcctc actgctaact ctcaacaaaa tgccccatga ttatgggcag gaaggacctc     3360



tagaaggcaa aatttagcct gctgacaatt tcccacaccg tgtaaaccaa agccctaaaa     3420



ttccactgcg ttgtccacaa gacagaagct gaagtgcatc caaaggtgct cagagagccg     3480



gcccgcctga atcattctcg atttaactcg agaccttttc aacttggctt cctttcttgg     3540



ttcataaatg aattttagtt tggttcactt acagatagta tctagcaatc acaacactgg     3600



ctgagcggat gcatctgggg atgaggttgc ttactaagct ttgccagctg ctgctggatc     3660



acagctgctt tctgttgtca ttgctgttgt ccctctgcta cgttcctatt gtcattaaag     3720



gtatcacggt cgccacctgg cattccttct gaccacagca tcattttgca ttcaaattaa     3780



gggttaagaa aagagatatt ttaaaatgag agtcacttga tgtgccattt taaaaaaaaa     3840



ggcatattgc tttttctaat gtggttattt ctctgatttg caaaaaaaaa aaaaaaaaaa     3900



atacttgtca atatttaaac atggttacaa tcattgctga aaatggtatt ttcccccttt     3960



tctgcatttt gctattgtaa atatgttttt tagatcaaat actttaaagg aaaaaatgtt     4020



ggatttataa atgctatttt ttattttact tttataataa aaggaaaagc aaattgatga     4080



cctcaaaaaa aaa                                                        4093





<210>  78

<211>  969

<212>  PRT

<213>  Homo sapiens



<400>  78



Met Ala Glu Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His 

1               5                   10                  15      





Leu Asp Pro Ser Leu Thr His Thr Ile Phe Asn Pro Glu Val Phe Gln 

            20                  25                  30          





Pro Gln Met Ala Leu Pro Thr Ala Asp Gly Pro Tyr Leu Gln Ile Leu 

        35                  40                  45              





Glu Gln Pro Lys Gln Arg Gly Phe Arg Phe Arg Tyr Val Cys Glu Gly 

    50                  55                  60                  





Pro Ser His Gly Gly Leu Pro Gly Ala Ser Ser Glu Lys Asn Lys Lys 

65                  70                  75                  80  





Ser Tyr Pro Gln Val Lys Ile Cys Asn Tyr Val Gly Pro Ala Lys Val 

                85                  90                  95      





Ile Val Gln Leu Val Thr Asn Gly Lys Asn Ile His Leu His Ala His 

            100                 105                 110         





Ser Leu Val Gly Lys His Cys Glu Asp Gly Ile Cys Thr Val Thr Ala 

        115                 120                 125             





Gly Pro Lys Asp Met Val Val Gly Phe Ala Asn Leu Gly Ile Leu His 

    130                 135                 140                 





Val Thr Lys Lys Lys Val Phe Glu Thr Leu Glu Ala Arg Met Thr Glu 

145                 150                 155                 160 





Ala Cys Ile Arg Gly Tyr Asn Pro Gly Leu Leu Val His Pro Asp Leu 

                165                 170                 175     





Ala Tyr Leu Gln Ala Glu Gly Gly Gly Asp Arg Gln Leu Gly Asp Arg 

            180                 185                 190         





Glu Lys Glu Leu Ile Arg Gln Ala Ala Leu Gln Gln Thr Lys Glu Met 

        195                 200                 205             





Asp Leu Ser Val Val Arg Leu Met Phe Thr Ala Phe Leu Pro Asp Ser 

    210                 215                 220                 





Thr Gly Ser Phe Thr Arg Arg Leu Glu Pro Val Val Ser Asp Ala Ile 

225                 230                 235                 240 





Tyr Asp Ser Lys Ala Pro Asn Ala Ser Asn Leu Lys Ile Val Arg Met 

                245                 250                 255     





Asp Arg Thr Ala Gly Cys Val Thr Gly Gly Glu Glu Ile Tyr Leu Leu 

            260                 265                 270         





Cys Asp Lys Val Gln Lys Asp Asp Ile Gln Ile Arg Phe Tyr Glu Glu 

        275                 280                 285             





Glu Glu Asn Gly Gly Val Trp Glu Gly Phe Gly Asp Phe Ser Pro Thr 

    290                 295                 300                 





Asp Val His Arg Gln Phe Ala Ile Val Phe Lys Thr Pro Lys Tyr Lys 

305                 310                 315                 320 





Asp Ile Asn Ile Thr Lys Pro Ala Ser Val Phe Val Gln Leu Arg Arg 

                325                 330                 335     





Lys Ser Asp Leu Glu Thr Ser Glu Pro Lys Pro Phe Leu Tyr Tyr Pro 

            340                 345                 350         





Glu Ile Lys Asp Lys Glu Glu Val Gln Arg Lys Arg Gln Lys Leu Met 

        355                 360                 365             





Pro Asn Phe Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala Gly Ala Gly 

    370                 375                 380                 





Gly Gly Gly Met Phe Gly Ser Gly Gly Gly Gly Gly Gly Thr Gly Ser 

385                 390                 395                 400 





Thr Gly Pro Gly Tyr Ser Phe Pro His Tyr Gly Phe Pro Thr Tyr Gly 

                405                 410                 415     





Gly Ile Thr Phe His Pro Gly Thr Thr Lys Ser Asn Ala Gly Met Lys 

            420                 425                 430         





His Gly Thr Met Asp Thr Glu Ser Lys Lys Asp Pro Glu Gly Cys Asp 

        435                 440                 445             





Lys Ser Asp Asp Lys Asn Thr Val Asn Leu Phe Gly Lys Val Ile Glu 

    450                 455                 460                 





Thr Thr Glu Gln Asp Gln Glu Pro Ser Glu Ala Thr Val Gly Asn Gly 

465                 470                 475                 480 





Glu Val Thr Leu Thr Tyr Ala Thr Gly Thr Lys Glu Glu Ser Ala Gly 

                485                 490                 495     





Val Gln Asp Asn Leu Phe Leu Glu Lys Ala Met Gln Leu Ala Lys Arg 

            500                 505                 510         





His Ala Asn Ala Leu Phe Asp Tyr Ala Val Thr Gly Asp Val Lys Met 

        515                 520                 525             





Leu Leu Ala Val Gln Arg His Leu Thr Ala Val Gln Asp Glu Asn Gly 

    530                 535                 540                 





Asp Ser Val Leu His Leu Ala Ile Ile His Leu His Ser Gln Leu Val 

545                 550                 555                 560 





Arg Asp Leu Leu Glu Val Thr Ser Gly Leu Ile Ser Asp Asp Ile Ile 

                565                 570                 575     





Asn Met Arg Asn Asp Leu Tyr Gln Thr Pro Leu His Leu Ala Val Ile 

            580                 585                 590         





Thr Lys Gln Glu Asp Val Val Glu Asp Leu Leu Arg Ala Gly Ala Asp 

        595                 600                 605             





Leu Ser Leu Leu Asp Arg Leu Gly Asn Ser Val Leu His Leu Ala Ala 

    610                 615                 620                 





Lys Glu Gly His Asp Lys Val Leu Ser Ile Leu Leu Lys His Lys Lys 

625                 630                 635                 640 





Ala Ala Leu Leu Leu Asp His Pro Asn Gly Asp Gly Leu Asn Ala Ile 

                645                 650                 655     





His Leu Ala Met Met Ser Asn Ser Leu Pro Cys Leu Leu Leu Leu Val 

            660                 665                 670         





Ala Ala Gly Ala Asp Val Asn Ala Gln Glu Gln Lys Ser Gly Arg Thr 

        675                 680                 685             





Ala Leu His Leu Ala Val Glu His Asp Asn Ile Ser Leu Ala Gly Cys 

    690                 695                 700                 





Leu Leu Leu Glu Gly Asp Ala His Val Asp Ser Thr Thr Tyr Asp Gly 

705                 710                 715                 720 





Thr Thr Pro Leu His Ile Ala Ala Gly Arg Gly Ser Thr Arg Leu Ala 

                725                 730                 735     





Ala Leu Leu Lys Ala Ala Gly Ala Asp Pro Leu Val Glu Asn Phe Glu 

            740                 745                 750         





Pro Leu Tyr Asp Leu Asp Asp Ser Trp Glu Asn Ala Gly Glu Asp Glu 

        755                 760                 765             





Gly Val Val Pro Gly Thr Thr Pro Leu Asp Met Ala Thr Ser Trp Gln 

    770                 775                 780                 





Val Phe Asp Ile Leu Asn Gly Lys Pro Tyr Glu Pro Glu Phe Thr Ser 

785                 790                 795                 800 





Asp Asp Leu Leu Ala Gln Gly Asp Met Lys Gln Leu Ala Glu Asp Val 

                805                 810                 815     





Lys Leu Gln Leu Tyr Lys Leu Leu Glu Ile Pro Asp Pro Asp Lys Asn 

            820                 825                 830         





Trp Ala Thr Leu Ala Gln Lys Leu Gly Leu Gly Ile Leu Asn Asn Ala 

        835                 840                 845             





Phe Arg Leu Ser Pro Ala Pro Ser Lys Thr Leu Met Asp Asn Tyr Glu 

    850                 855                 860                 





Val Ser Gly Gly Thr Val Arg Glu Leu Val Glu Ala Leu Arg Gln Met 

865                 870                 875                 880 





Gly Tyr Thr Glu Ala Ile Glu Val Ile Gln Ala Ala Ser Ser Pro Val 

                885                 890                 895     





Lys Thr Thr Ser Gln Ala His Ser Leu Pro Leu Ser Pro Ala Ser Thr 

            900                 905                 910         





Arg Gln Gln Ile Asp Glu Leu Arg Asp Ser Asp Ser Val Cys Asp Ser 

        915                 920                 925             





Gly Val Glu Thr Ser Phe Arg Lys Leu Ser Phe Thr Glu Ser Leu Thr 

    930                 935                 940                 





Ser Gly Ala Ser Leu Leu Thr Leu Asn Lys Met Pro His Asp Tyr Gly 

945                 950                 955                 960 





Gln Glu Gly Pro Leu Glu Gly Lys Ile 

                965                 





<210>  79

<211>  3140

<212>  DNA

<213>  Homo sapiens



<400>  79

ggcgggcgct cggcgactcg tccccggggc cccgcgcggg cccgggcagc aggggcgtga       60



tgtcacggca gggagggggc gcgggagccg ccgggccggc ggggaggcgg gggaggtgtt      120



ttccagcttt aaaaaggcag gaggcagagc gcggccctgc gtcagagcga gactcagagg      180



ctccgaactc gccggcggag tcgccgcgcc agatcccagc agcagggcgc gggcaccggg      240



gcgcgggcag ggctcggagc caccgcgcag gtcctagggc cgcggccggg ccccgccacg      300



cgcgcacacg cccctcgatg actttcctcc ggggcgcgcg gcgctgagcc cggggcgagg      360



gctgtcttcc cggagacccg accccggcag cgcggggcgg ccgcttctcc tgtgcctccg      420



cccgccgctc cactccccgc cgccgccgcg cggatgccaa gcaccagctt tccagtccct      480



tccaagtttc cacttggccc tgcggctgcg gtcttcggga gaggagaaac tttggggccc      540



gcgccgcgcg ccggcggcac catgaagtca gcggaggaag aacactatgg ctatgcatcc      600



tccaacgtca gccccgccct gccgctcccc acggcgcact ccaccctgcc ggccccgtgc      660



cacaaccttc agacctccac accgggcatc atcccgccgg cggatcaccc ctcggggtac      720



ggagcagctt tggacggtgg gcccgcgggc tacttcctct cctccggcca caccaggcct      780



gatggggccc ctgccctgga gagtcctcgc atcgagataa cctcgtgctt gggcctgtac      840



cacaacaata accagttttt ccacgatgtg gaggtggaag acgtcctccc tagctccaaa      900



cggtccccct ccacggccac gctgagtctg cccagcctgg aggcctacag agacccctcg      960



tgcctgagcc cggccagcag cctgtcctcc cggagctgca actcagaggc ctcctcctac     1020



gagtccaact actcgtaccc gtacgcgtcc ccccagacgt cgccatggca gtctccctgc     1080



gtgtctccca agaccacgga ccccgaggag ggctttcccc gcgggctggg ggcctgcaca     1140



ctgctgggtt ccccgcggca ctccccctcc acctcgcccc gcgccagcgt cactgaggag     1200



agctggctgg gtgcccgctc ctccagaccc gcgtcccctt gcaacaagag gaagtacagc     1260



ctcaacggcc ggcagccgcc ctactcaccc caccactcgc ccacgccgtc cccgcacggc     1320



tccccgcggg tcagcgtgac cgacgactcg tggttgggca acaccaccca gtacaccagc     1380



tcggccatcg tggccgccat caacgcgctg accaccgaca gcagcctgga cctgggagat     1440



ggcgtccctg tcaagtcccg caagaccacc ctggagcagc cgccctcagt ggcgctcaag     1500



gtggagcccg tcggggagga cctgggcagc cccccgcccc cggccgactt cgcgcccgaa     1560



gactactcct ctttccagca catcaggaag ggcggcttct gcgaccagta cctggcggtg     1620



ccgcagcacc cctaccagtg ggcgaagccc aagcccctgt cccctacgtc ctacatgagc     1680



ccgaccctgc ccgccctgga ctggcagctg ccgtcccact caggcccgta tgagcttcgg     1740



attgaggtgc agcccaagtc ccaccaccga gcccactacg agacggaggg cagccggggg     1800



gccgtgaagg cgtcggccgg aggacacccc atcgtgcagc tgcatggcta cttggagaat     1860



gagccgctga tgctgcagct tttcattggg acggcggacg accgcctgct gcgcccgcac     1920



gccttctacc aggtgcaccg catcacaggg aagaccgtgt ccaccaccag ccacgaggcc     1980



atcctctcca acaccaaagt cctggagatc ccactcctgc cggagaacag catgcgagcc     2040



gtcattgact gtgccggaat cctgaaactc agaaactccg acattgaact tcggaaagga     2100



gagacggaca tcgggaggaa gaacacacgg gtacggctgg tgttccgcgt tcacgtcccg     2160



caacccagcg gccgcacgct gtccctgcag gtggcctcca accccatcga atgctcccag     2220



cgctcagctc aggagctgcc tctggtggag aagcagagca cggacagcta tccggtcgtg     2280



ggcgggaaga agatggtcct gtctggccac aacttcctgc aggactccaa ggtcattttc     2340



gtggagaaag ccccagatgg ccaccatgtc tgggagatgg aagcgaaaac tgaccgggac     2400



ctgtgcaagc cgaattctct ggtggttgag atcccgccat ttcggaatca gaggataacc     2460



agccccgttc acgtcagttt ctacgtctgc aacgggaaga gaaagcgaag ccagtaccag     2520



cgtttcacct accttcccgc caacggtaac gccatctttc taaccgtaag ccgtgaacat     2580



gagcgcgtgg ggtgcttttt ctaaagacgc agaaacgacg tcgccgtaaa gcagcgtggc     2640



gtgttgcaca tttaactgtg tgatgtcccg ttagtgagac cgagccatcg atgccctgaa     2700



aaggaaagga aaagggaagc ttcggatgca ttttccttga tccctgttgg gggtgggggg     2760



cgggggttgc atactcagat agtcacggtt attttgcttc ttgcgaatgt ataacagcca     2820



aggggaaaac atggctcttc tgctccaaaa aactgagggg gtcctggtgt gcatttgcac     2880



cctaaagctg cttacggtga aaaggcaaat aggtatagct attttgcagg cacctttagg     2940



aataaacttt gcttttaagc ctgtagtcct gatgtggtct ttaaggatgg tgaatgagct     3000



ttgtgctggg cggacgtccc cgagacactt ctccaggggt aacttcatct cctgggacca     3060



cgggcatcca ggctggggca ccttctcctc aacctgcctg cccctcaccc gccgtgggaa     3120



tggctccttt tcactcatac                                                 3140





<210>  80

<211>  716

<212>  PRT

<213>  Homo sapiens



<400>  80



Met Pro Ser Thr Ser Phe Pro Val Pro Ser Lys Phe Pro Leu Gly Pro 

1               5                   10                  15      





Ala Ala Ala Val Phe Gly Arg Gly Glu Thr Leu Gly Pro Ala Pro Arg 

            20                  25                  30          





Ala Gly Gly Thr Met Lys Ser Ala Glu Glu Glu His Tyr Gly Tyr Ala 

        35                  40                  45              





Ser Ser Asn Val Ser Pro Ala Leu Pro Leu Pro Thr Ala His Ser Thr 

    50                  55                  60                  





Leu Pro Ala Pro Cys His Asn Leu Gln Thr Ser Thr Pro Gly Ile Ile 

65                  70                  75                  80  





Pro Pro Ala Asp His Pro Ser Gly Tyr Gly Ala Ala Leu Asp Gly Gly 

                85                  90                  95      





Pro Ala Gly Tyr Phe Leu Ser Ser Gly His Thr Arg Pro Asp Gly Ala 

            100                 105                 110         





Pro Ala Leu Glu Ser Pro Arg Ile Glu Ile Thr Ser Cys Leu Gly Leu 

        115                 120                 125             





Tyr His Asn Asn Asn Gln Phe Phe His Asp Val Glu Val Glu Asp Val 

    130                 135                 140                 





Leu Pro Ser Ser Lys Arg Ser Pro Ser Thr Ala Thr Leu Ser Leu Pro 

145                 150                 155                 160 





Ser Leu Glu Ala Tyr Arg Asp Pro Ser Cys Leu Ser Pro Ala Ser Ser 

                165                 170                 175     





Leu Ser Ser Arg Ser Cys Asn Ser Glu Ala Ser Ser Tyr Glu Ser Asn 

            180                 185                 190         





Tyr Ser Tyr Pro Tyr Ala Ser Pro Gln Thr Ser Pro Trp Gln Ser Pro 

        195                 200                 205             





Cys Val Ser Pro Lys Thr Thr Asp Pro Glu Glu Gly Phe Pro Arg Gly 

    210                 215                 220                 





Leu Gly Ala Cys Thr Leu Leu Gly Ser Pro Arg His Ser Pro Ser Thr 

225                 230                 235                 240 





Ser Pro Arg Ala Ser Val Thr Glu Glu Ser Trp Leu Gly Ala Arg Ser 

                245                 250                 255     





Ser Arg Pro Ala Ser Pro Cys Asn Lys Arg Lys Tyr Ser Leu Asn Gly 

            260                 265                 270         





Arg Gln Pro Pro Tyr Ser Pro His His Ser Pro Thr Pro Ser Pro His 

        275                 280                 285             





Gly Ser Pro Arg Val Ser Val Thr Asp Asp Ser Trp Leu Gly Asn Thr 

    290                 295                 300                 





Thr Gln Tyr Thr Ser Ser Ala Ile Val Ala Ala Ile Asn Ala Leu Thr 

305                 310                 315                 320 





Thr Asp Ser Ser Leu Asp Leu Gly Asp Gly Val Pro Val Lys Ser Arg 

                325                 330                 335     





Lys Thr Thr Leu Glu Gln Pro Pro Ser Val Ala Leu Lys Val Glu Pro 

            340                 345                 350         





Val Gly Glu Asp Leu Gly Ser Pro Pro Pro Pro Ala Asp Phe Ala Pro 

        355                 360                 365             





Glu Asp Tyr Ser Ser Phe Gln His Ile Arg Lys Gly Gly Phe Cys Asp 

    370                 375                 380                 





Gln Tyr Leu Ala Val Pro Gln His Pro Tyr Gln Trp Ala Lys Pro Lys 

385                 390                 395                 400 





Pro Leu Ser Pro Thr Ser Tyr Met Ser Pro Thr Leu Pro Ala Leu Asp 

                405                 410                 415     





Trp Gln Leu Pro Ser His Ser Gly Pro Tyr Glu Leu Arg Ile Glu Val 

            420                 425                 430         





Gln Pro Lys Ser His His Arg Ala His Tyr Glu Thr Glu Gly Ser Arg 

        435                 440                 445             





Gly Ala Val Lys Ala Ser Ala Gly Gly His Pro Ile Val Gln Leu His 

    450                 455                 460                 





Gly Tyr Leu Glu Asn Glu Pro Leu Met Leu Gln Leu Phe Ile Gly Thr 

465                 470                 475                 480 





Ala Asp Asp Arg Leu Leu Arg Pro His Ala Phe Tyr Gln Val His Arg 

                485                 490                 495     





Ile Thr Gly Lys Thr Val Ser Thr Thr Ser His Glu Ala Ile Leu Ser 

            500                 505                 510         





Asn Thr Lys Val Leu Glu Ile Pro Leu Leu Pro Glu Asn Ser Met Arg 

        515                 520                 525             





Ala Val Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn Ser Asp Ile 

    530                 535                 540                 





Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn Thr Arg Val 

545                 550                 555                 560 





Arg Leu Val Phe Arg Val His Val Pro Gln Pro Ser Gly Arg Thr Leu 

                565                 570                 575     





Ser Leu Gln Val Ala Ser Asn Pro Ile Glu Cys Ser Gln Arg Ser Ala 

            580                 585                 590         





Gln Glu Leu Pro Leu Val Glu Lys Gln Ser Thr Asp Ser Tyr Pro Val 

        595                 600                 605             





Val Gly Gly Lys Lys Met Val Leu Ser Gly His Asn Phe Leu Gln Asp 

    610                 615                 620                 





Ser Lys Val Ile Phe Val Glu Lys Ala Pro Asp Gly His His Val Trp 

625                 630                 635                 640 





Glu Met Glu Ala Lys Thr Asp Arg Asp Leu Cys Lys Pro Asn Ser Leu 

                645                 650                 655     





Val Val Glu Ile Pro Pro Phe Arg Asn Gln Arg Ile Thr Ser Pro Val 

            660                 665                 670         





His Val Ser Phe Tyr Val Cys Asn Gly Lys Arg Lys Arg Ser Gln Tyr 

        675                 680                 685             





Gln Arg Phe Thr Tyr Leu Pro Ala Asn Gly Asn Ala Ile Phe Leu Thr 

    690                 695                 700                 





Val Ser Arg Glu His Glu Arg Val Gly Cys Phe Phe 

705                 710                 715     





<210>  81

<211>  4762

<212>  DNA

<213>  Homo sapiens



<400>  81

ggcgggcgct cggcgactcg tccccggggc cccgcgcggg cccgggcagc aggggcgtga       60



tgtcacggca gggagggggc gcgggagccg ccgggccggc ggggaggcgg gggaggtgtt      120



ttccagcttt aaaaaggcag gaggcagagc gcggccctgc gtcagagcga gactcagagg      180



ctccgaactc gccggcggag tcgccgcgcc agatcccagc agcagggcgc gggcaccggg      240



gcgcgggcag ggctcggagc caccgcgcag gtcctagggc cgcggccggg ccccgccacg      300



cgcgcacacg cccctcgatg actttcctcc ggggcgcgcg gcgctgagcc cggggcgagg      360



gctgtcttcc cggagacccg accccggcag cgcggggcgg ccgcttctcc tgtgcctccg      420



cccgccgctc cactccccgc cgccgccgcg cggatgccaa gcaccagctt tccagtccct      480



tccaagtttc cacttggccc tgcggctgcg gtcttcggga gaggagaaac tttggggccc      540



gcgccgcgcg ccggcggcac catgaagtca gcggaggaag aacactatgg ctatgcatcc      600



tccaacgtca gccccgccct gccgctcccc acggcgcact ccaccctgcc ggccccgtgc      660



cacaaccttc agacctccac accgggcatc atcccgccgg cggatcaccc ctcggggtac      720



ggagcagctt tggacggtgg gcccgcgggc tacttcctct cctccggcca caccaggcct      780



gatggggccc ctgccctgga gagtcctcgc atcgagataa cctcgtgctt gggcctgtac      840



cacaacaata accagttttt ccacgatgtg gaggtggaag acgtcctccc tagctccaaa      900



cggtccccct ccacggccac gctgagtctg cccagcctgg aggcctacag agacccctcg      960



tgcctgagcc cggccagcag cctgtcctcc cggagctgca actcagaggc ctcctcctac     1020



gagtccaact actcgtaccc gtacgcgtcc ccccagacgt cgccatggca gtctccctgc     1080



gtgtctccca agaccacgga ccccgaggag ggctttcccc gcgggctggg ggcctgcaca     1140



ctgctgggtt ccccgcggca ctccccctcc acctcgcccc gcgccagcgt cactgaggag     1200



agctggctgg gtgcccgctc ctccagaccc gcgtcccctt gcaacaagag gaagtacagc     1260



ctcaacggcc ggcagccgcc ctactcaccc caccactcgc ccacgccgtc cccgcacggc     1320



tccccgcggg tcagcgtgac cgacgactcg tggttgggca acaccaccca gtacaccagc     1380



tcggccatcg tggccgccat caacgcgctg accaccgaca gcagcctgga cctgggagat     1440



ggcgtccctg tcaagtcccg caagaccacc ctggagcagc cgccctcagt ggcgctcaag     1500



gtggagcccg tcggggagga cctgggcagc cccccgcccc cggccgactt cgcgcccgaa     1560



gactactcct ctttccagca catcaggaag ggcggcttct gcgaccagta cctggcggtg     1620



ccgcagcacc cctaccagtg ggcgaagccc aagcccctgt cccctacgtc ctacatgagc     1680



ccgaccctgc ccgccctgga ctggcagctg ccgtcccact caggcccgta tgagcttcgg     1740



attgaggtgc agcccaagtc ccaccaccga gcccactacg agacggaggg cagccggggg     1800



gccgtgaagg cgtcggccgg aggacacccc atcgtgcagc tgcatggcta cttggagaat     1860



gagccgctga tgctgcagct tttcattggg acggcggacg accgcctgct gcgcccgcac     1920



gccttctacc aggtgcaccg catcacaggg aagaccgtgt ccaccaccag ccacgaggcc     1980



atcctctcca acaccaaagt cctggagatc ccactcctgc cggagaacag catgcgagcc     2040



gtcattgact gtgccggaat cctgaaactc agaaactccg acattgaact tcggaaagga     2100



gagacggaca tcgggaggaa gaacacacgg gtacggctgg tgttccgcgt tcacgtcccg     2160



caacccagcg gccgcacgct gtccctgcag gtggcctcca accccatcga atgctcccag     2220



cgctcagctc aggagctgcc tctggtggag aagcagagca cggacagcta tccggtcgtg     2280



ggcgggaaga agatggtcct gtctggccac aacttcctgc aggactccaa ggtcattttc     2340



gtggagaaag ccccagatgg ccaccatgtc tgggagatgg aagcgaaaac tgaccgggac     2400



ctgtgcaagc cgaattctct ggtggttgag atcccgccat ttcggaatca gaggataacc     2460



agccccgttc acgtcagttt ctacgtctgc aacgggaaga gaaagcgaag ccagtaccag     2520



cgtttcacct accttcccgc caacgttcca attataaaaa cagaacccac tgatgattat     2580



gagcctgctc caacctgtgg accggtgagc caggggttaa gtcctctccc aagaccatac     2640



tacagccagc agctcgcgat gccacccgac cccagctcct gcctcgtggc cggcttcccg     2700



ccctgtccgc agagaagcac cctgatgcca gcggcccctg gcgtgagccc caagctccac     2760



gacctttctc ccgctgccta caccaagggc gttgccagcc cgggccactg tcacctcgga     2820



ctcccgcagc cggccggaga ggcccccgcc gtccaggacg tgcccaggcc agtggccacg     2880



caccccggct cgcccgggca gccacccccg gccctgctgc cacagcagta aatgaaataa     2940



tacgaaatga cctctccagc acgagcaccc actcctagtt gccacattgg agcactcagt     3000



tcagcagggg tatgctgact tcagcagaca aagacttttg aataaataaa ctgaactcac     3060



acctggtacc actcagaacc tccaactgac tgaatgccag gagctgaaca ttaatatgtg     3120



caaagattgg ctctccaaca agaaggaaag cagggaggaa gggagaccac tgtgtcacct     3180



ggaggagaag tcatctcatg acaacagaag ggaggtggcc gggctgagca cgggagaccc     3240



accgtgcagg ggcctttcat gggaacggcc cacacgcagt ttgaccccac gcccagccct     3300



tctggcaccc ctggggttca atactggaag tgccttattt aaccagacca tcagggcatc     3360



atagaattga gcattgaatt tgctactgta ggagtatttt taggagcaga aactgcaaac     3420



acatttcatt gtgaggtttt accctctgta tgaatgaaga gaacgctgga aggctgcgag     3480



aggactctag tatgagtctc caacatttgg aacgtttcct gggctgtcac gtacactcct     3540



gctgccttac acagtgcatt ttagaatctt ccagtctgtc atctcagctc ttttgtaaca     3600



tgcttccctt gtctgcgcgg ttgaaaccgt aggcttgttc atagtcgcat gctcgcatct     3660



ttgtttttaa tctggcttcg aacatagcac aagtaacttg aatagcacat caataggtta     3720



ctggacaaaa gcagaaaaac ctgttacagg atagcctgca tttgcatgtg tgtacatatc     3780



taggcatcta tttatgtata aataataaca gagccgacgt gtcctcgccc aggagggctt     3840



ccctgtcagc aataaccggc atccgttttg gaacctgcgt ctggggctcc agtcgctgct     3900



cttgctggcg tccatcgccg cctcggacgg ccgtgcattt tctcgtctca cgcagttcga     3960



ggaggaccct agaaagccag gagctgtgat tgacagtagc tgtaggttac cagacggcaa     4020



cattagaaag tgattgtaaa taacatgcaa cctaagtgta atatatttgt tcagttataa     4080



gatgattgtt tcacagaagc cttaccactc tctgcttcat ctaagaaaac caataccaaa     4140



aacgccactt taatgctcag ccctgcgttg tgtgttttca gatgagttac tgttaacagg     4200



taggtttgtg taggccttgc tgggcactct gtacaattag ttgcttatta cgtatgatta     4260



ctcacagcga tctattgttc catataacca aaaagcatgg tttattcatt gaaacacggt     4320



tgacctgaac tcgtgcctta ggaattaatg cccccttatg gaacctgcct gaattgcacc     4380



tgcgggtgga ggctccggct gtgaagtcac tgaacagaac gtcgctgatg gagaaagggc     4440



tcccgcagaa ggaacggcct gtaccgtgcg ctccggcaca atcgcgtctc ttgtgtctca     4500



ctcacggaaa gaaacaacct gaaggccatc ccgtcggtct gcacgtaacc gtgaagacgt     4560



gtggccgcgt cccacctgcg gctgggtacc ctgcacccgg cactgtagga gtcacgtgca     4620



gcctttctca ggggactgtc attgaaaagg aaacgtttga tgtctgtgtc agctgtcttt     4680



gtagttagga aatagatcca ataaagccgt atttttttgc tggaaaaaaa aaaaaaaaaa     4740



aaaaaaaaaa aaaaaaaaaa aa                                              4762





<210>  82

<211>  825

<212>  PRT

<213>  Homo sapiens



<400>  82



Met Pro Ser Thr Ser Phe Pro Val Pro Ser Lys Phe Pro Leu Gly Pro 

1               5                   10                  15      





Ala Ala Ala Val Phe Gly Arg Gly Glu Thr Leu Gly Pro Ala Pro Arg 

            20                  25                  30          





Ala Gly Gly Thr Met Lys Ser Ala Glu Glu Glu His Tyr Gly Tyr Ala 

        35                  40                  45              





Ser Ser Asn Val Ser Pro Ala Leu Pro Leu Pro Thr Ala His Ser Thr 

    50                  55                  60                  





Leu Pro Ala Pro Cys His Asn Leu Gln Thr Ser Thr Pro Gly Ile Ile 

65                  70                  75                  80  





Pro Pro Ala Asp His Pro Ser Gly Tyr Gly Ala Ala Leu Asp Gly Gly 

                85                  90                  95      





Pro Ala Gly Tyr Phe Leu Ser Ser Gly His Thr Arg Pro Asp Gly Ala 

            100                 105                 110         





Pro Ala Leu Glu Ser Pro Arg Ile Glu Ile Thr Ser Cys Leu Gly Leu 

        115                 120                 125             





Tyr His Asn Asn Asn Gln Phe Phe His Asp Val Glu Val Glu Asp Val 

    130                 135                 140                 





Leu Pro Ser Ser Lys Arg Ser Pro Ser Thr Ala Thr Leu Ser Leu Pro 

145                 150                 155                 160 





Ser Leu Glu Ala Tyr Arg Asp Pro Ser Cys Leu Ser Pro Ala Ser Ser 

                165                 170                 175     





Leu Ser Ser Arg Ser Cys Asn Ser Glu Ala Ser Ser Tyr Glu Ser Asn 

            180                 185                 190         





Tyr Ser Tyr Pro Tyr Ala Ser Pro Gln Thr Ser Pro Trp Gln Ser Pro 

        195                 200                 205             





Cys Val Ser Pro Lys Thr Thr Asp Pro Glu Glu Gly Phe Pro Arg Gly 

    210                 215                 220                 





Leu Gly Ala Cys Thr Leu Leu Gly Ser Pro Arg His Ser Pro Ser Thr 

225                 230                 235                 240 





Ser Pro Arg Ala Ser Val Thr Glu Glu Ser Trp Leu Gly Ala Arg Ser 

                245                 250                 255     





Ser Arg Pro Ala Ser Pro Cys Asn Lys Arg Lys Tyr Ser Leu Asn Gly 

            260                 265                 270         





Arg Gln Pro Pro Tyr Ser Pro His His Ser Pro Thr Pro Ser Pro His 

        275                 280                 285             





Gly Ser Pro Arg Val Ser Val Thr Asp Asp Ser Trp Leu Gly Asn Thr 

    290                 295                 300                 





Thr Gln Tyr Thr Ser Ser Ala Ile Val Ala Ala Ile Asn Ala Leu Thr 

305                 310                 315                 320 





Thr Asp Ser Ser Leu Asp Leu Gly Asp Gly Val Pro Val Lys Ser Arg 

                325                 330                 335     





Lys Thr Thr Leu Glu Gln Pro Pro Ser Val Ala Leu Lys Val Glu Pro 

            340                 345                 350         





Val Gly Glu Asp Leu Gly Ser Pro Pro Pro Pro Ala Asp Phe Ala Pro 

        355                 360                 365             





Glu Asp Tyr Ser Ser Phe Gln His Ile Arg Lys Gly Gly Phe Cys Asp 

    370                 375                 380                 





Gln Tyr Leu Ala Val Pro Gln His Pro Tyr Gln Trp Ala Lys Pro Lys 

385                 390                 395                 400 





Pro Leu Ser Pro Thr Ser Tyr Met Ser Pro Thr Leu Pro Ala Leu Asp 

                405                 410                 415     





Trp Gln Leu Pro Ser His Ser Gly Pro Tyr Glu Leu Arg Ile Glu Val 

            420                 425                 430         





Gln Pro Lys Ser His His Arg Ala His Tyr Glu Thr Glu Gly Ser Arg 

        435                 440                 445             





Gly Ala Val Lys Ala Ser Ala Gly Gly His Pro Ile Val Gln Leu His 

    450                 455                 460                 





Gly Tyr Leu Glu Asn Glu Pro Leu Met Leu Gln Leu Phe Ile Gly Thr 

465                 470                 475                 480 





Ala Asp Asp Arg Leu Leu Arg Pro His Ala Phe Tyr Gln Val His Arg 

                485                 490                 495     





Ile Thr Gly Lys Thr Val Ser Thr Thr Ser His Glu Ala Ile Leu Ser 

            500                 505                 510         





Asn Thr Lys Val Leu Glu Ile Pro Leu Leu Pro Glu Asn Ser Met Arg 

        515                 520                 525             





Ala Val Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn Ser Asp Ile 

    530                 535                 540                 





Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn Thr Arg Val 

545                 550                 555                 560 





Arg Leu Val Phe Arg Val His Val Pro Gln Pro Ser Gly Arg Thr Leu 

                565                 570                 575     





Ser Leu Gln Val Ala Ser Asn Pro Ile Glu Cys Ser Gln Arg Ser Ala 

            580                 585                 590         





Gln Glu Leu Pro Leu Val Glu Lys Gln Ser Thr Asp Ser Tyr Pro Val 

        595                 600                 605             





Val Gly Gly Lys Lys Met Val Leu Ser Gly His Asn Phe Leu Gln Asp 

    610                 615                 620                 





Ser Lys Val Ile Phe Val Glu Lys Ala Pro Asp Gly His His Val Trp 

625                 630                 635                 640 





Glu Met Glu Ala Lys Thr Asp Arg Asp Leu Cys Lys Pro Asn Ser Leu 

                645                 650                 655     





Val Val Glu Ile Pro Pro Phe Arg Asn Gln Arg Ile Thr Ser Pro Val 

            660                 665                 670         





His Val Ser Phe Tyr Val Cys Asn Gly Lys Arg Lys Arg Ser Gln Tyr 

        675                 680                 685             





Gln Arg Phe Thr Tyr Leu Pro Ala Asn Val Pro Ile Ile Lys Thr Glu 

    690                 695                 700                 





Pro Thr Asp Asp Tyr Glu Pro Ala Pro Thr Cys Gly Pro Val Ser Gln 

705                 710                 715                 720 





Gly Leu Ser Pro Leu Pro Arg Pro Tyr Tyr Ser Gln Gln Leu Ala Met 

                725                 730                 735     





Pro Pro Asp Pro Ser Ser Cys Leu Val Ala Gly Phe Pro Pro Cys Pro 

            740                 745                 750         





Gln Arg Ser Thr Leu Met Pro Ala Ala Pro Gly Val Ser Pro Lys Leu 

        755                 760                 765             





His Asp Leu Ser Pro Ala Ala Tyr Thr Lys Gly Val Ala Ser Pro Gly 

    770                 775                 780                 





His Cys His Leu Gly Leu Pro Gln Pro Ala Gly Glu Ala Pro Ala Val 

785                 790                 795                 800 





Gln Asp Val Pro Arg Pro Val Ala Thr His Pro Gly Ser Pro Gly Gln 

                805                 810                 815     





Pro Pro Pro Ala Leu Leu Pro Gln Gln 

            820                 825 





<210>  83

<211>  4621

<212>  DNA

<213>  Homo sapiens



<400>  83

gccgggagaa ccgaacccct ggcggccgcg accccggctc ccgccccggc cccggcccga       60



cccgccatga cggggctgga ggaccaggag ttcgacttcg agttcctctt cgagtttaac      120



cagcgcgacg agggcgccgc cgcggccgcc ccagaacact atggctatgc atcctccaac      180



gtcagccccg ccctgccgct ccccacggcg cactccaccc tgccggcccc gtgccacaac      240



cttcagacct ccacaccggg catcatcccg ccggcggatc acccctcggg gtacggagca      300



gctttggacg gtgggcccgc gggctacttc ctctcctccg gccacaccag gcctgatggg      360



gcccctgccc tggagagtcc tcgcatcgag ataacctcgt gcttgggcct gtaccacaac      420



aataaccagt ttttccacga tgtggaggtg gaagacgtcc tccctagctc caaacggtcc      480



ccctccacgg ccacgctgag tctgcccagc ctggaggcct acagagaccc ctcgtgcctg      540



agcccggcca gcagcctgtc ctcccggagc tgcaactcag aggcctcctc ctacgagtcc      600



aactactcgt acccgtacgc gtccccccag acgtcgccat ggcagtctcc ctgcgtgtct      660



cccaagacca cggaccccga ggagggcttt ccccgcgggc tgggggcctg cacactgctg      720



ggttccccgc ggcactcccc ctccacctcg ccccgcgcca gcgtcactga ggagagctgg      780



ctgggtgccc gctcctccag acccgcgtcc ccttgcaaca agaggaagta cagcctcaac      840



ggccggcagc cgccctactc accccaccac tcgcccacgc cgtccccgca cggctccccg      900



cgggtcagcg tgaccgacga ctcgtggttg ggcaacacca cccagtacac cagctcggcc      960



atcgtggccg ccatcaacgc gctgaccacc gacagcagcc tggacctggg agatggcgtc     1020



cctgtcaagt cccgcaagac caccctggag cagccgccct cagtggcgct caaggtggag     1080



cccgtcgggg aggacctggg cagccccccg cccccggccg acttcgcgcc cgaagactac     1140



tcctctttcc agcacatcag gaagggcggc ttctgcgacc agtacctggc ggtgccgcag     1200



cacccctacc agtgggcgaa gcccaagccc ctgtccccta cgtcctacat gagcccgacc     1260



ctgcccgccc tggactggca gctgccgtcc cactcaggcc cgtatgagct tcggattgag     1320



gtgcagccca agtcccacca ccgagcccac tacgagacgg agggcagccg gggggccgtg     1380



aaggcgtcgg ccggaggaca ccccatcgtg cagctgcatg gctacttgga gaatgagccg     1440



ctgatgctgc agcttttcat tgggacggcg gacgaccgcc tgctgcgccc gcacgccttc     1500



taccaggtgc accgcatcac agggaagacc gtgtccacca ccagccacga ggccatcctc     1560



tccaacacca aagtcctgga gatcccactc ctgccggaga acagcatgcg agccgtcatt     1620



gactgtgccg gaatcctgaa actcagaaac tccgacattg aacttcggaa aggagagacg     1680



gacatcggga ggaagaacac acgggtacgg ctggtgttcc gcgttcacgt cccgcaaccc     1740



agcggccgca cgctgtccct gcaggtggcc tccaacccca tcgaatgctc ccagcgctca     1800



gctcaggagc tgcctctggt ggagaagcag agcacggaca gctatccggt cgtgggcggg     1860



aagaagatgg tcctgtctgg ccacaacttc ctgcaggact ccaaggtcat tttcgtggag     1920



aaagccccag atggccacca tgtctgggag atggaagcga aaactgaccg ggacctgtgc     1980



aagccgaatt ctctggtggt tgagatcccg ccatttcgga atcagaggat aaccagcccc     2040



gttcacgtca gtttctacgt ctgcaacggg aagagaaagc gaagccagta ccagcgtttc     2100



acctaccttc ccgccaacgt tccaattata aaaacagaac ccactgatga ttatgagcct     2160



gctccaacct gtggaccggt gagccagggg ttaagtcctc tcccaagacc atactacagc     2220



cagcagctcg cgatgccacc cgaccccagc tcctgcctcg tggccggctt cccgccctgt     2280



ccgcagagaa gcaccctgat gccagcggcc cctggcgtga gccccaagct ccacgacctt     2340



tctcccgctg cctacaccaa gggcgttgcc agcccgggcc actgtcacct cggactcccg     2400



cagccggccg gagaggcccc cgccgtccag gacgtgccca ggccagtggc cacgcacccc     2460



ggctcgcccg ggcagccacc cccggccctg ctgccacagc aggtgagtgc gcctccaagc     2520



agtagctgcc cccctggtct cgaacactcg ctctgcccca gcagcccctc tcctccactc     2580



ccgcctgcca cccaagagcc gacctgcctg cagccctgca gcccagcgtg cccgcccgcc     2640



acgggccgcc cgcagcacct gccgtccacg gtccgcaggg acgagtctcc gactgccggg     2700



ccacggctgc tgccagaggt gcatgaggac ggtagtccta atttggcccc tattcctgta     2760



acggtcaagc gagagcctga agagttggac cagttgtacc tggatgacgt aaatgaaata     2820



atacgaaatg acctctccag cacgagcacc cactcctagt tgccacattg gagcactcag     2880



ttcagcaggg gtatgctgac ttcagcagac aaagactttt gaataaataa actgaactca     2940



cacctggtac cactcagaac ctccaactga ctgaatgcca ggagctgaac attaatatgt     3000



gcaaagattg gctctccaac aagaaggaaa gcagggagga agggagacca ctgtgtcacc     3060



tggaggagaa gtcatctcat gacaacagaa gggaggtggc cgggctgagc acgggagacc     3120



caccgtgcag gggcctttca tgggaacggc ccacacgcag tttgacccca cgcccagccc     3180



ttctggcacc cctggggttc aatactggaa gtgccttatt taaccagacc atcagggcat     3240



catagaattg agcattgaat ttgctactgt aggagtattt ttaggagcag aaactgcaaa     3300



cacatttcat tgtgaggttt taccctctgt atgaatgaag agaacgctgg aaggctgcga     3360



gaggactcta gtatgagtct ccaacatttg gaacgtttcc tgggctgtca cgtacactcc     3420



tgctgcctta cacagtgcat tttagaatct tccagtctgt catctcagct cttttgtaac     3480



atgcttccct tgtctgcgcg gttgaaaccg taggcttgtt catagtcgca tgctcgcatc     3540



tttgttttta atctggcttc gaacatagca caagtaactt gaatagcaca tcaataggtt     3600



actggacaaa agcagaaaaa cctgttacag gatagcctgc atttgcatgt gtgtacatat     3660



ctaggcatct atttatgtat aaataataac agagccgacg tgtcctcgcc caggagggct     3720



tccctgtcag caataaccgg catccgtttt ggaacctgcg tctggggctc cagtcgctgc     3780



tcttgctggc gtccatcgcc gcctcggacg gccgtgcatt ttctcgtctc acgcagttcg     3840



aggaggaccc tagaaagcca ggagctgtga ttgacagtag ctgtaggtta ccagacggca     3900



acattagaaa gtgattgtaa ataacatgca acctaagtgt aatatatttg ttcagttata     3960



agatgattgt ttcacagaag ccttaccact ctctgcttca tctaagaaaa ccaataccaa     4020



aaacgccact ttaatgctca gccctgcgtt gtgtgttttc agatgagtta ctgttaacag     4080



gtaggtttgt gtaggccttg ctgggcactc tgtacaatta gttgcttatt acgtatgatt     4140



actcacagcg atctattgtt ccatataacc aaaaagcatg gtttattcat tgaaacacgg     4200



ttgacctgaa ctcgtgcctt aggaattaat gcccccttat ggaacctgcc tgaattgcac     4260



ctgcgggtgg aggctccggc tgtgaagtca ctgaacagaa cgtcgctgat ggagaaaggg     4320



ctcccgcaga aggaacggcc tgtaccgtgc gctccggcac aatcgcgtct cttgtgtctc     4380



actcacggaa agaaacaacc tgaaggccat cccgtcggtc tgcacgtaac cgtgaagacg     4440



tgtggccgcg tcccacctgc ggctgggtac cctgcacccg gcactgtagg agtcacgtgc     4500



agcctttctc aggggactgt cattgaaaag gaaacgtttg atgtctgtgt cagctgtctt     4560



tgtagttagg aaatagatcc aataaagccg tatttttttg ctggaaaaaa aaaaaaaaaa     4620



a                                                                     4621





<210>  84

<211>  930

<212>  PRT

<213>  Homo sapiens



<400>  84



Met Thr Gly Leu Glu Asp Gln Glu Phe Asp Phe Glu Phe Leu Phe Glu 

1               5                   10                  15      





Phe Asn Gln Arg Asp Glu Gly Ala Ala Ala Ala Ala Pro Glu His Tyr 

            20                  25                  30          





Gly Tyr Ala Ser Ser Asn Val Ser Pro Ala Leu Pro Leu Pro Thr Ala 

        35                  40                  45              





His Ser Thr Leu Pro Ala Pro Cys His Asn Leu Gln Thr Ser Thr Pro 

    50                  55                  60                  





Gly Ile Ile Pro Pro Ala Asp His Pro Ser Gly Tyr Gly Ala Ala Leu 

65                  70                  75                  80  





Asp Gly Gly Pro Ala Gly Tyr Phe Leu Ser Ser Gly His Thr Arg Pro 

                85                  90                  95      





Asp Gly Ala Pro Ala Leu Glu Ser Pro Arg Ile Glu Ile Thr Ser Cys 

            100                 105                 110         





Leu Gly Leu Tyr His Asn Asn Asn Gln Phe Phe His Asp Val Glu Val 

        115                 120                 125             





Glu Asp Val Leu Pro Ser Ser Lys Arg Ser Pro Ser Thr Ala Thr Leu 

    130                 135                 140                 





Ser Leu Pro Ser Leu Glu Ala Tyr Arg Asp Pro Ser Cys Leu Ser Pro 

145                 150                 155                 160 





Ala Ser Ser Leu Ser Ser Arg Ser Cys Asn Ser Glu Ala Ser Ser Tyr 

                165                 170                 175     





Glu Ser Asn Tyr Ser Tyr Pro Tyr Ala Ser Pro Gln Thr Ser Pro Trp 

            180                 185                 190         





Gln Ser Pro Cys Val Ser Pro Lys Thr Thr Asp Pro Glu Glu Gly Phe 

        195                 200                 205             





Pro Arg Gly Leu Gly Ala Cys Thr Leu Leu Gly Ser Pro Arg His Ser 

    210                 215                 220                 





Pro Ser Thr Ser Pro Arg Ala Ser Val Thr Glu Glu Ser Trp Leu Gly 

225                 230                 235                 240 





Ala Arg Ser Ser Arg Pro Ala Ser Pro Cys Asn Lys Arg Lys Tyr Ser 

                245                 250                 255     





Leu Asn Gly Arg Gln Pro Pro Tyr Ser Pro His His Ser Pro Thr Pro 

            260                 265                 270         





Ser Pro His Gly Ser Pro Arg Val Ser Val Thr Asp Asp Ser Trp Leu 

        275                 280                 285             





Gly Asn Thr Thr Gln Tyr Thr Ser Ser Ala Ile Val Ala Ala Ile Asn 

    290                 295                 300                 





Ala Leu Thr Thr Asp Ser Ser Leu Asp Leu Gly Asp Gly Val Pro Val 

305                 310                 315                 320 





Lys Ser Arg Lys Thr Thr Leu Glu Gln Pro Pro Ser Val Ala Leu Lys 

                325                 330                 335     





Val Glu Pro Val Gly Glu Asp Leu Gly Ser Pro Pro Pro Pro Ala Asp 

            340                 345                 350         





Phe Ala Pro Glu Asp Tyr Ser Ser Phe Gln His Ile Arg Lys Gly Gly 

        355                 360                 365             





Phe Cys Asp Gln Tyr Leu Ala Val Pro Gln His Pro Tyr Gln Trp Ala 

    370                 375                 380                 





Lys Pro Lys Pro Leu Ser Pro Thr Ser Tyr Met Ser Pro Thr Leu Pro 

385                 390                 395                 400 





Ala Leu Asp Trp Gln Leu Pro Ser His Ser Gly Pro Tyr Glu Leu Arg 

                405                 410                 415     





Ile Glu Val Gln Pro Lys Ser His His Arg Ala His Tyr Glu Thr Glu 

            420                 425                 430         





Gly Ser Arg Gly Ala Val Lys Ala Ser Ala Gly Gly His Pro Ile Val 

        435                 440                 445             





Gln Leu His Gly Tyr Leu Glu Asn Glu Pro Leu Met Leu Gln Leu Phe 

    450                 455                 460                 





Ile Gly Thr Ala Asp Asp Arg Leu Leu Arg Pro His Ala Phe Tyr Gln 

465                 470                 475                 480 





Val His Arg Ile Thr Gly Lys Thr Val Ser Thr Thr Ser His Glu Ala 

                485                 490                 495     





Ile Leu Ser Asn Thr Lys Val Leu Glu Ile Pro Leu Leu Pro Glu Asn 

            500                 505                 510         





Ser Met Arg Ala Val Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn 

        515                 520                 525             





Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn 

    530                 535                 540                 





Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln Pro Ser Gly 

545                 550                 555                 560 





Arg Thr Leu Ser Leu Gln Val Ala Ser Asn Pro Ile Glu Cys Ser Gln 

                565                 570                 575     





Arg Ser Ala Gln Glu Leu Pro Leu Val Glu Lys Gln Ser Thr Asp Ser 

            580                 585                 590         





Tyr Pro Val Val Gly Gly Lys Lys Met Val Leu Ser Gly His Asn Phe 

        595                 600                 605             





Leu Gln Asp Ser Lys Val Ile Phe Val Glu Lys Ala Pro Asp Gly His 

    610                 615                 620                 





His Val Trp Glu Met Glu Ala Lys Thr Asp Arg Asp Leu Cys Lys Pro 

625                 630                 635                 640 





Asn Ser Leu Val Val Glu Ile Pro Pro Phe Arg Asn Gln Arg Ile Thr 

                645                 650                 655     





Ser Pro Val His Val Ser Phe Tyr Val Cys Asn Gly Lys Arg Lys Arg 

            660                 665                 670         





Ser Gln Tyr Gln Arg Phe Thr Tyr Leu Pro Ala Asn Val Pro Ile Ile 

        675                 680                 685             





Lys Thr Glu Pro Thr Asp Asp Tyr Glu Pro Ala Pro Thr Cys Gly Pro 

    690                 695                 700                 





Val Ser Gln Gly Leu Ser Pro Leu Pro Arg Pro Tyr Tyr Ser Gln Gln 

705                 710                 715                 720 





Leu Ala Met Pro Pro Asp Pro Ser Ser Cys Leu Val Ala Gly Phe Pro 

                725                 730                 735     





Pro Cys Pro Gln Arg Ser Thr Leu Met Pro Ala Ala Pro Gly Val Ser 

            740                 745                 750         





Pro Lys Leu His Asp Leu Ser Pro Ala Ala Tyr Thr Lys Gly Val Ala 

        755                 760                 765             





Ser Pro Gly His Cys His Leu Gly Leu Pro Gln Pro Ala Gly Glu Ala 

    770                 775                 780                 





Pro Ala Val Gln Asp Val Pro Arg Pro Val Ala Thr His Pro Gly Ser 

785                 790                 795                 800 





Pro Gly Gln Pro Pro Pro Ala Leu Leu Pro Gln Gln Val Ser Ala Pro 

                805                 810                 815     





Pro Ser Ser Ser Cys Pro Pro Gly Leu Glu His Ser Leu Cys Pro Ser 

            820                 825                 830         





Ser Pro Ser Pro Pro Leu Pro Pro Ala Thr Gln Glu Pro Thr Cys Leu 

        835                 840                 845             





Gln Pro Cys Ser Pro Ala Cys Pro Pro Ala Thr Gly Arg Pro Gln His 

    850                 855                 860                 





Leu Pro Ser Thr Val Arg Arg Asp Glu Ser Pro Thr Ala Gly Pro Arg 

865                 870                 875                 880 





Leu Leu Pro Glu Val His Glu Asp Gly Ser Pro Asn Leu Ala Pro Ile 

                885                 890                 895     





Pro Val Thr Val Lys Arg Glu Pro Glu Glu Leu Asp Gln Leu Tyr Leu 

            900                 905                 910         





Asp Asp Val Asn Glu Ile Ile Arg Asn Asp Leu Ser Ser Thr Ser Thr 

        915                 920                 925             





His Ser 

    930 





<210>  85

<211>  3671

<212>  DNA

<213>  Homo sapiens



<400>  85

ggcgggcgct cggcgactcg tccccggggc cccgcgcggg cccgggcagc aggggcgtga       60



tgtcacggca gggagggggc gcgggagccg ccgggccggc ggggaggcgg gggaggtgtt      120



ttccagcttt aaaaaggcag gaggcagagc gcggccctgc gtcagagcga gactcagagg      180



ctccgaactc gccggcggag tcgccgcgcc agatcccagc agcagggcgc gggcaccggg      240



gcgcgggcag ggctcggagc caccgcgcag gtcctagggc cgcggccggg ccccgccacg      300



cgcgcacacg cccctcgatg actttcctcc ggggcgcgcg gcgctgagcc cggggcgagg      360



gctgtcttcc cggagacccg accccggcag cgcggggcgg ccgcttctcc tgtgcctccg      420



cccgccgctc cactccccgc cgccgccgcg cggatgccaa gcaccagctt tccagtccct      480



tccaagtttc cacttggccc tgcggctgcg gtcttcggga gaggagaaac tttggggccc      540



gcgccgcgcg ccggcggcac catgaagtca gcggaggaag cccgaccctg cccgccctgg      600



actggcagct gccgtcccac tcaggcccgt atgagcttcg gattgaggtg cagcccaagt      660



cccaccaccg agcccactac gagacggagg gcagccgggg ggccgtgaag gcgtcggccg      720



gaggacaccc catcgtgcag ctgcatggct acttggagaa tgagccgctg atgctgcagc      780



ttttcattgg gacggcggac gaccgcctgc tgcgcccgca cgccttctac caggtgcacc      840



gcatcacagg gaagaccgtg tccaccacca gccacgaggc catcctctcc aacaccaaag      900



tcctggagat cccactcctg ccggagaaca gcatgcgagc cgtcattgac tgtgccggaa      960



tcctgaaact cagaaactcc gacattgaac ttcggaaagg agagacggac atcgggagga     1020



agaacacacg ggtacggctg gtgttccgcg ttcacgtccc gcaacccagc ggccgcacgc     1080



tgtccctgca ggtggcctcc aaccccatcg aatgctccca gcgctcagct caggagctgc     1140



ctctggtgga gaagcagagc acggacagct atccggtcgt gggcgggaag aagatggtcc     1200



tgtctggcca caacttcctg caggactcca aggtcatttt cgtggagaaa gccccagatg     1260



gccaccatgt ctgggagatg gaagcgaaaa ctgaccggga cctgtgcaag ccgaattctc     1320



tggtggttga gatcccgcca tttcggaatc agaggataac cagccccgtt cacgtcagtt     1380



tctacgtctg caacgggaag agaaagcgaa gccagtacca gcgtttcacc taccttcccg     1440



ccaacgttcc aattataaaa acagaaccca ctgatgatta tgagcctgct ccaacctgtg     1500



gaccggtgag ccaggggtta agtcctctcc caagaccata ctacagccag cagctcgcga     1560



tgccacccga ccccagctcc tgcctcgtgg ccggcttccc gccctgtccg cagagaagca     1620



ccctgatgcc agcggcccct ggcgtgagcc ccaagctcca cgacctttct cccgctgcct     1680



acaccaaggg cgttgccagc ccgggccact gtcacctcgg actcccgcag ccggccggag     1740



aggcccccgc cgtccaggac gtgcccaggc cagtggccac gcaccccggc tcgcccgggc     1800



agccaccccc ggccctgctg ccacagcagt aaatgaaata atacgaaatg acctctccag     1860



cacgagcacc cactcctagt tgccacattg gagcactcag ttcagcaggg gtatgctgac     1920



ttcagcagac aaagactttt gaataaataa actgaactca cacctggtac cactcagaac     1980



ctccaactga ctgaatgcca ggagctgaac attaatatgt gcaaagattg gctctccaac     2040



aagaaggaaa gcagggagga agggagacca ctgtgtcacc tggaggagaa gtcatctcat     2100



gacaacagaa gggaggtggc cgggctgagc acgggagacc caccgtgcag gggcctttca     2160



tgggaacggc ccacacgcag tttgacccca cgcccagccc ttctggcacc cctggggttc     2220



aatactggaa gtgccttatt taaccagacc atcagggcat catagaattg agcattgaat     2280



ttgctactgt aggagtattt ttaggagcag aaactgcaaa cacatttcat tgtgaggttt     2340



taccctctgt atgaatgaag agaacgctgg aaggctgcga gaggactcta gtatgagtct     2400



ccaacatttg gaacgtttcc tgggctgtca cgtacactcc tgctgcctta cacagtgcat     2460



tttagaatct tccagtctgt catctcagct cttttgtaac atgcttccct tgtctgcgcg     2520



gttgaaaccg taggcttgtt catagtcgca tgctcgcatc tttgttttta atctggcttc     2580



gaacatagca caagtaactt gaatagcaca tcaataggtt actggacaaa agcagaaaaa     2640



cctgttacag gatagcctgc atttgcatgt gtgtacatat ctaggcatct atttatgtat     2700



aaataataac agagccgacg tgtcctcgcc caggagggct tccctgtcag caataaccgg     2760



catccgtttt ggaacctgcg tctggggctc cagtcgctgc tcttgctggc gtccatcgcc     2820



gcctcggacg gccgtgcatt ttctcgtctc acgcagttcg aggaggaccc tagaaagcca     2880



ggagctgtga ttgacagtag ctgtaggtta ccagacggca acattagaaa gtgattgtaa     2940



ataacatgca acctaagtgt aatatatttg ttcagttata agatgattgt ttcacagaag     3000



ccttaccact ctctgcttca tctaagaaaa ccaataccaa aaacgccact ttaatgctca     3060



gccctgcgtt gtgtgttttc agatgagtta ctgttaacag gtaggtttgt gtaggccttg     3120



ctgggcactc tgtacaatta gttgcttatt acgtatgatt actcacagcg atctattgtt     3180



ccatataacc aaaaagcatg gtttattcat tgaaacacgg ttgacctgaa ctcgtgcctt     3240



aggaattaat gcccccttat ggaacctgcc tgaattgcac ctgcgggtgg aggctccggc     3300



tgtgaagtca ctgaacagaa cgtcgctgat ggagaaaggg ctcccgcaga aggaacggcc     3360



tgtaccgtgc gctccggcac aatcgcgtct cttgtgtctc actcacggaa agaaacaacc     3420



tgaaggccat cccgtcggtc tgcacgtaac cgtgaagacg tgtggccgcg tcccacctgc     3480



ggctgggtac cctgcacccg gcactgtagg agtcacgtgc agcctttctc aggggactgt     3540



cattgaaaag gaaacgtttg atgtctgtgt cagctgtctt tgtagttagg aaatagatcc     3600



aataaagccg tatttttttg ctggaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3660



aaaaaaaaaa a                                                          3671





<210>  86

<211>  353

<212>  PRT

<213>  Homo sapiens



<400>  86



Met Leu Gln Leu Phe Ile Gly Thr Ala Asp Asp Arg Leu Leu Arg Pro 

1               5                   10                  15      





His Ala Phe Tyr Gln Val His Arg Ile Thr Gly Lys Thr Val Ser Thr 

            20                  25                  30          





Thr Ser His Glu Ala Ile Leu Ser Asn Thr Lys Val Leu Glu Ile Pro 

        35                  40                  45              





Leu Leu Pro Glu Asn Ser Met Arg Ala Val Ile Asp Cys Ala Gly Ile 

    50                  55                  60                  





Leu Lys Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp 

65                  70                  75                  80  





Ile Gly Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val 

                85                  90                  95      





Pro Gln Pro Ser Gly Arg Thr Leu Ser Leu Gln Val Ala Ser Asn Pro 

            100                 105                 110         





Ile Glu Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Leu Val Glu Lys 

        115                 120                 125             





Gln Ser Thr Asp Ser Tyr Pro Val Val Gly Gly Lys Lys Met Val Leu 

    130                 135                 140                 





Ser Gly His Asn Phe Leu Gln Asp Ser Lys Val Ile Phe Val Glu Lys 

145                 150                 155                 160 





Ala Pro Asp Gly His His Val Trp Glu Met Glu Ala Lys Thr Asp Arg 

                165                 170                 175     





Asp Leu Cys Lys Pro Asn Ser Leu Val Val Glu Ile Pro Pro Phe Arg 

            180                 185                 190         





Asn Gln Arg Ile Thr Ser Pro Val His Val Ser Phe Tyr Val Cys Asn 

        195                 200                 205             





Gly Lys Arg Lys Arg Ser Gln Tyr Gln Arg Phe Thr Tyr Leu Pro Ala 

    210                 215                 220                 





Asn Val Pro Ile Ile Lys Thr Glu Pro Thr Asp Asp Tyr Glu Pro Ala 

225                 230                 235                 240 





Pro Thr Cys Gly Pro Val Ser Gln Gly Leu Ser Pro Leu Pro Arg Pro 

                245                 250                 255     





Tyr Tyr Ser Gln Gln Leu Ala Met Pro Pro Asp Pro Ser Ser Cys Leu 

            260                 265                 270         





Val Ala Gly Phe Pro Pro Cys Pro Gln Arg Ser Thr Leu Met Pro Ala 

        275                 280                 285             





Ala Pro Gly Val Ser Pro Lys Leu His Asp Leu Ser Pro Ala Ala Tyr 

    290                 295                 300                 





Thr Lys Gly Val Ala Ser Pro Gly His Cys His Leu Gly Leu Pro Gln 

305                 310                 315                 320 





Pro Ala Gly Glu Ala Pro Ala Val Gln Asp Val Pro Arg Pro Val Ala 

                325                 330                 335     





Thr His Pro Gly Ser Pro Gly Gln Pro Pro Pro Ala Leu Leu Pro Gln 

            340                 345                 350         





Gln 

    





<210>  87

<211>  4336

<212>  DNA

<213>  Homo sapiens



<400>  87

gccgggagaa ccgaacccct ggcggccgcg accccggctc ccgccccggc cccggcccga       60



cccgccatga cggggctgga ggaccaggag ttcgacttcg agttcctctt cgagtttaac      120



cagcgcgacg agggcgccgc cgcggccgcc ccagaacact atggctatgc atcctccaac      180



gtcagccccg ccctgccgct ccccacggcg cactccaccc tgccggcccc gtgccacaac      240



cttcagacct ccacaccggg catcatcccg ccggcggatc acccctcggg gtacggagca      300



gctttggacg gtgggcccgc gggctacttc ctctcctccg gccacaccag gcctgatggg      360



gcccctgccc tggagagtcc tcgcatcgag ataacctcgt gcttgggcct gtaccacaac      420



aataaccagt ttttccacga tgtggaggtg gaagacgtcc tccctagctc caaacggtcc      480



ccctccacgg ccacgctgag tctgcccagc ctggaggcct acagagaccc ctcgtgcctg      540



agcccggcca gcagcctgtc ctcccggagc tgcaactcag aggcctcctc ctacgagtcc      600



aactactcgt acccgtacgc gtccccccag acgtcgccat ggcagtctcc ctgcgtgtct      660



cccaagacca cggaccccga ggagggcttt ccccgcgggc tgggggcctg cacactgctg      720



ggttccccgc ggcactcccc ctccacctcg ccccgcgcca gcgtcactga ggagagctgg      780



ctgggtgccc gctcctccag acccgcgtcc ccttgcaaca agaggaagta cagcctcaac      840



ggccggcagc cgccctactc accccaccac tcgcccacgc cgtccccgca cggctccccg      900



cgggtcagcg tgaccgacga ctcgtggttg ggcaacacca cccagtacac cagctcggcc      960



atcgtggccg ccatcaacgc gctgaccacc gacagcagcc tggacctggg agatggcgtc     1020



cctgtcaagt cccgcaagac caccctggag cagccgccct cagtggcgct caaggtggag     1080



cccgtcgggg aggacctggg cagccccccg cccccggccg acttcgcgcc cgaagactac     1140



tcctctttcc agcacatcag gaagggcggc ttctgcgacc agtacctggc ggtgccgcag     1200



cacccctacc agtgggcgaa gcccaagccc ctgtccccta cgtcctacat gagcccgacc     1260



ctgcccgccc tggactggca gctgccgtcc cactcaggcc cgtatgagct tcggattgag     1320



gtgcagccca agtcccacca ccgagcccac tacgagacgg agggcagccg gggggccgtg     1380



aaggcgtcgg ccggaggaca ccccatcgtg cagctgcatg gctacttgga gaatgagccg     1440



ctgatgctgc agcttttcat tgggacggcg gacgaccgcc tgctgcgccc gcacgccttc     1500



taccaggtgc accgcatcac agggaagacc gtgtccacca ccagccacga ggccatcctc     1560



tccaacacca aagtcctgga gatcccactc ctgccggaga acagcatgcg agccgtcatt     1620



gactgtgccg gaatcctgaa actcagaaac tccgacattg aacttcggaa aggagagacg     1680



gacatcggga ggaagaacac acgggtacgg ctggtgttcc gcgttcacgt cccgcaaccc     1740



agcggccgca cgctgtccct gcaggtggcc tccaacccca tcgaatgctc ccagcgctca     1800



gctcaggagc tgcctctggt ggagaagcag agcacggaca gctatccggt cgtgggcggg     1860



aagaagatgg tcctgtctgg ccacaacttc ctgcaggact ccaaggtcat tttcgtggag     1920



aaagccccag atggccacca tgtctgggag atggaagcga aaactgaccg ggacctgtgc     1980



aagccgaatt ctctggtggt tgagatcccg ccatttcgga atcagaggat aaccagcccc     2040



gttcacgtca gtttctacgt ctgcaacggg aagagaaagc gaagccagta ccagcgtttc     2100



acctaccttc ccgccaacgt tccaattata aaaacagaac ccactgatga ttatgagcct     2160



gctccaacct gtggaccggt gagccagggg ttaagtcctc tcccaagacc atactacagc     2220



cagcagctcg cgatgccacc cgaccccagc tcctgcctcg tggccggctt cccgccctgt     2280



ccgcagagaa gcaccctgat gccagcggcc cctggcgtga gccccaagct ccacgacctt     2340



tctcccgctg cctacaccaa gggcgttgcc agcccgggcc actgtcacct cggactcccg     2400



cagccggccg gagaggcccc cgccgtccag gacgtgccca ggccagtggc cacgcacccc     2460



ggctcgcccg ggcagccacc cccggccctg ctgccacagc agtaaatgaa ataatacgaa     2520



atgacctctc cagcacgagc acccactcct agttgccaca ttggagcact cagttcagca     2580



ggggtatgct gacttcagca gacaaagact tttgaataaa taaactgaac tcacacctgg     2640



taccactcag aacctccaac tgactgaatg ccaggagctg aacattaata tgtgcaaaga     2700



ttggctctcc aacaagaagg aaagcaggga ggaagggaga ccactgtgtc acctggagga     2760



gaagtcatct catgacaaca gaagggaggt ggccgggctg agcacgggag acccaccgtg     2820



caggggcctt tcatgggaac ggcccacacg cagtttgacc ccacgcccag cccttctggc     2880



acccctgggg ttcaatactg gaagtgcctt atttaaccag accatcaggg catcatagaa     2940



ttgagcattg aatttgctac tgtaggagta tttttaggag cagaaactgc aaacacattt     3000



cattgtgagg ttttaccctc tgtatgaatg aagagaacgc tggaaggctg cgagaggact     3060



ctagtatgag tctccaacat ttggaacgtt tcctgggctg tcacgtacac tcctgctgcc     3120



ttacacagtg cattttagaa tcttccagtc tgtcatctca gctcttttgt aacatgcttc     3180



ccttgtctgc gcggttgaaa ccgtaggctt gttcatagtc gcatgctcgc atctttgttt     3240



ttaatctggc ttcgaacata gcacaagtaa cttgaatagc acatcaatag gttactggac     3300



aaaagcagaa aaacctgtta caggatagcc tgcatttgca tgtgtgtaca tatctaggca     3360



tctatttatg tataaataat aacagagccg acgtgtcctc gcccaggagg gcttccctgt     3420



cagcaataac cggcatccgt tttggaacct gcgtctgggg ctccagtcgc tgctcttgct     3480



ggcgtccatc gccgcctcgg acggccgtgc attttctcgt ctcacgcagt tcgaggagga     3540



ccctagaaag ccaggagctg tgattgacag tagctgtagg ttaccagacg gcaacattag     3600



aaagtgattg taaataacat gcaacctaag tgtaatatat ttgttcagtt ataagatgat     3660



tgtttcacag aagccttacc actctctgct tcatctaaga aaaccaatac caaaaacgcc     3720



actttaatgc tcagccctgc gttgtgtgtt ttcagatgag ttactgttaa caggtaggtt     3780



tgtgtaggcc ttgctgggca ctctgtacaa ttagttgctt attacgtatg attactcaca     3840



gcgatctatt gttccatata accaaaaagc atggtttatt cattgaaaca cggttgacct     3900



gaactcgtgc cttaggaatt aatgccccct tatggaacct gcctgaattg cacctgcggg     3960



tggaggctcc ggctgtgaag tcactgaaca gaacgtcgct gatggagaaa gggctcccgc     4020



agaaggaacg gcctgtaccg tgcgctccgg cacaatcgcg tctcttgtgt ctcactcacg     4080



gaaagaaaca acctgaaggc catcccgtcg gtctgcacgt aaccgtgaag acgtgtggcc     4140



gcgtcccacc tgcggctggg taccctgcac ccggcactgt aggagtcacg tgcagccttt     4200



ctcaggggac tgtcattgaa aaggaaacgt ttgatgtctg tgtcagctgt ctttgtagtt     4260



aggaaataga tccaataaag ccgtattttt ttgctggaaa aaaaaaaaaa aaaaaaaaaa     4320



aaaaaaaaaa aaaaaa                                                     4336





<210>  88

<211>  812

<212>  PRT

<213>  Homo sapiens



<400>  88



Met Thr Gly Leu Glu Asp Gln Glu Phe Asp Phe Glu Phe Leu Phe Glu 

1               5                   10                  15      





Phe Asn Gln Arg Asp Glu Gly Ala Ala Ala Ala Ala Pro Glu His Tyr 

            20                  25                  30          





Gly Tyr Ala Ser Ser Asn Val Ser Pro Ala Leu Pro Leu Pro Thr Ala 

        35                  40                  45              





His Ser Thr Leu Pro Ala Pro Cys His Asn Leu Gln Thr Ser Thr Pro 

    50                  55                  60                  





Gly Ile Ile Pro Pro Ala Asp His Pro Ser Gly Tyr Gly Ala Ala Leu 

65                  70                  75                  80  





Asp Gly Gly Pro Ala Gly Tyr Phe Leu Ser Ser Gly His Thr Arg Pro 

                85                  90                  95      





Asp Gly Ala Pro Ala Leu Glu Ser Pro Arg Ile Glu Ile Thr Ser Cys 

            100                 105                 110         





Leu Gly Leu Tyr His Asn Asn Asn Gln Phe Phe His Asp Val Glu Val 

        115                 120                 125             





Glu Asp Val Leu Pro Ser Ser Lys Arg Ser Pro Ser Thr Ala Thr Leu 

    130                 135                 140                 





Ser Leu Pro Ser Leu Glu Ala Tyr Arg Asp Pro Ser Cys Leu Ser Pro 

145                 150                 155                 160 





Ala Ser Ser Leu Ser Ser Arg Ser Cys Asn Ser Glu Ala Ser Ser Tyr 

                165                 170                 175     





Glu Ser Asn Tyr Ser Tyr Pro Tyr Ala Ser Pro Gln Thr Ser Pro Trp 

            180                 185                 190         





Gln Ser Pro Cys Val Ser Pro Lys Thr Thr Asp Pro Glu Glu Gly Phe 

        195                 200                 205             





Pro Arg Gly Leu Gly Ala Cys Thr Leu Leu Gly Ser Pro Arg His Ser 

    210                 215                 220                 





Pro Ser Thr Ser Pro Arg Ala Ser Val Thr Glu Glu Ser Trp Leu Gly 

225                 230                 235                 240 





Ala Arg Ser Ser Arg Pro Ala Ser Pro Cys Asn Lys Arg Lys Tyr Ser 

                245                 250                 255     





Leu Asn Gly Arg Gln Pro Pro Tyr Ser Pro His His Ser Pro Thr Pro 

            260                 265                 270         





Ser Pro His Gly Ser Pro Arg Val Ser Val Thr Asp Asp Ser Trp Leu 

        275                 280                 285             





Gly Asn Thr Thr Gln Tyr Thr Ser Ser Ala Ile Val Ala Ala Ile Asn 

    290                 295                 300                 





Ala Leu Thr Thr Asp Ser Ser Leu Asp Leu Gly Asp Gly Val Pro Val 

305                 310                 315                 320 





Lys Ser Arg Lys Thr Thr Leu Glu Gln Pro Pro Ser Val Ala Leu Lys 

                325                 330                 335     





Val Glu Pro Val Gly Glu Asp Leu Gly Ser Pro Pro Pro Pro Ala Asp 

            340                 345                 350         





Phe Ala Pro Glu Asp Tyr Ser Ser Phe Gln His Ile Arg Lys Gly Gly 

        355                 360                 365             





Phe Cys Asp Gln Tyr Leu Ala Val Pro Gln His Pro Tyr Gln Trp Ala 

    370                 375                 380                 





Lys Pro Lys Pro Leu Ser Pro Thr Ser Tyr Met Ser Pro Thr Leu Pro 

385                 390                 395                 400 





Ala Leu Asp Trp Gln Leu Pro Ser His Ser Gly Pro Tyr Glu Leu Arg 

                405                 410                 415     





Ile Glu Val Gln Pro Lys Ser His His Arg Ala His Tyr Glu Thr Glu 

            420                 425                 430         





Gly Ser Arg Gly Ala Val Lys Ala Ser Ala Gly Gly His Pro Ile Val 

        435                 440                 445             





Gln Leu His Gly Tyr Leu Glu Asn Glu Pro Leu Met Leu Gln Leu Phe 

    450                 455                 460                 





Ile Gly Thr Ala Asp Asp Arg Leu Leu Arg Pro His Ala Phe Tyr Gln 

465                 470                 475                 480 





Val His Arg Ile Thr Gly Lys Thr Val Ser Thr Thr Ser His Glu Ala 

                485                 490                 495     





Ile Leu Ser Asn Thr Lys Val Leu Glu Ile Pro Leu Leu Pro Glu Asn 

            500                 505                 510         





Ser Met Arg Ala Val Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn 

        515                 520                 525             





Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn 

    530                 535                 540                 





Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln Pro Ser Gly 

545                 550                 555                 560 





Arg Thr Leu Ser Leu Gln Val Ala Ser Asn Pro Ile Glu Cys Ser Gln 

                565                 570                 575     





Arg Ser Ala Gln Glu Leu Pro Leu Val Glu Lys Gln Ser Thr Asp Ser 

            580                 585                 590         





Tyr Pro Val Val Gly Gly Lys Lys Met Val Leu Ser Gly His Asn Phe 

        595                 600                 605             





Leu Gln Asp Ser Lys Val Ile Phe Val Glu Lys Ala Pro Asp Gly His 

    610                 615                 620                 





His Val Trp Glu Met Glu Ala Lys Thr Asp Arg Asp Leu Cys Lys Pro 

625                 630                 635                 640 





Asn Ser Leu Val Val Glu Ile Pro Pro Phe Arg Asn Gln Arg Ile Thr 

                645                 650                 655     





Ser Pro Val His Val Ser Phe Tyr Val Cys Asn Gly Lys Arg Lys Arg 

            660                 665                 670         





Ser Gln Tyr Gln Arg Phe Thr Tyr Leu Pro Ala Asn Val Pro Ile Ile 

        675                 680                 685             





Lys Thr Glu Pro Thr Asp Asp Tyr Glu Pro Ala Pro Thr Cys Gly Pro 

    690                 695                 700                 





Val Ser Gln Gly Leu Ser Pro Leu Pro Arg Pro Tyr Tyr Ser Gln Gln 

705                 710                 715                 720 





Leu Ala Met Pro Pro Asp Pro Ser Ser Cys Leu Val Ala Gly Phe Pro 

                725                 730                 735     





Pro Cys Pro Gln Arg Ser Thr Leu Met Pro Ala Ala Pro Gly Val Ser 

            740                 745                 750         





Pro Lys Leu His Asp Leu Ser Pro Ala Ala Tyr Thr Lys Gly Val Ala 

        755                 760                 765             





Ser Pro Gly His Cys His Leu Gly Leu Pro Gln Pro Ala Gly Glu Ala 

    770                 775                 780                 





Pro Ala Val Gln Asp Val Pro Arg Pro Val Ala Thr His Pro Gly Ser 

785                 790                 795                 800 





Pro Gly Gln Pro Pro Pro Ala Leu Leu Pro Gln Gln 

                805                 810         





<210>  89

<211>  2974

<212>  DNA

<213>  Homo sapiens



<400>  89

atgcagagag aggctgcgtt cagactgggg cactgccatc ccctccgcat catggggtct       60



gtggaccaag aagagccgaa tgcacataag gtcgccagcc caccctccgg acccgcatac      120



cccgatgatg tcctggacta tggcctcaag ccatacagcc cccttgctag tctctctggc      180



gagccccccg gccgattcgg agagccggat agggtagggc cgcagaagtt tctgagcgcg      240



gccaagccag caggggcctc gggcctgagc cctcggatcg agatcactcc gtcccacgaa      300



ctgatccagg cagtggggcc cctccgcatg agagacgcgg gcctcctggt ggagcagccg      360



cccctggccg gggtggccgc cagcccgagg ttcaccctgc ccgtgcccgg cttcgagggc      420



taccgcgagc cgctttgctt gagccccgct agcagcggct cctctgccag cttcatttct      480



gacaccttct ccccctacac ctcgccctgc gtctcgccca ataacggcgg gcccgacgac      540



ctgtgtccgc agtttcaaaa catccctgct cattattccc ccagaacctc gccaataatg      600



tcacctcgaa ccagcctcgc cgaggacagc tgcctgggcc gccactcgcc cgtgccccgt      660



ccggcctccc gctcctcatc gcctggtgcc aagcggaggc attcgtgcgc cgaggccttg      720



gttgccctgc cgcccggagc ctcaccccag cgctcccgga gcccctcgcc gcagccctca      780



tctcacgtgg caccccagga ccacggctcc ccggctgggt acccccctgt ggctggctct      840



gccgtgatca tggatgccct gaacagcctc gccacggact cgccttgtgg gatccccccc      900



aagatgtgga agaccagccc tgacccctcg ccggtgtctg ccgccccatc caaggccggc      960



ctgcctcgcc acatctaccc ggccgtggag ttcctggggc cctgcgagca gggcgagagg     1020



agaaactcgg ctccagaatc catcctgctg gttccgccca cttggcccaa gccgctggtg     1080



cctgccattc ccatctgcag catcccagtg actgcatccc tccctccact tgagtggccg     1140



ctgtccagtc agtcaggctc ttacgagctg cggatcgagg tgcagcccaa gccacatcac     1200



cgggcccact atgagacaga aggcagccga ggggctgtca aagctccaac tggaggccac     1260



cctgtggttc agctccatgg ctacatggaa aacaagcctc tgggacttca gatcttcatt     1320



gggacagctg atgagcggat ccttaagccg cacgccttct accaggtgca ccgaatcacg     1380



gggaaaactg tcaccaccac cagctatgag aagatagtgg gcaacaccaa agtcctggag     1440



atacccttgg agcccaaaaa caacatgagg gcaaccatcg actgtgcggg gatcttgaag     1500



cttagaaacg ccgacattga gctgcggaaa ggcgagacgg acattggaag aaagaacacg     1560



cgggtgagac tggttttccg agttcacatc ccagagtcca gtggcagaat cgtctcttta     1620



cagactgcat ctaaccccat cgagtgctcc cagcgatctg ctcacgagct gcccatggtt     1680



gaaagacaag acacagacag ctgcctggtc tatggcggcc agcaaatgat cctcacgggg     1740



cagaacttta catccgagtc caaagttgtg tttactgaga agaccacaga tggacagcaa     1800



atttgggaga tggaagccac ggtggataag gacaagagcc agcccaacat gctttttgtt     1860



gagatccctg aatatcggaa caagcatatc cgcacacctg taaaagtgaa cttctacgtc     1920



atcaatggga agagaaaacg aagtcagcct cagcacttta cctaccaccc agtcccagcc     1980



atcaagacgg agcccacgga tgaatatgac cccactctga tctgcagccc cacccatgga     2040



ggcctgggga gccagcctta ctacccccag cacccgatgg tggccgagtc cccctcctgc     2100



ctcgtggcca ccatggctcc ctgccagcag ttccgcacgg ggctctcatc ccctgacgcc     2160



cgctaccagc aacagaaccc agcggccgta ctctaccagc ggagcaagag cctgagcccc     2220



agcctgctgg gctatcagca gccggccctc atggccgccc cgctgtccct tgcggacgct     2280



caccgctctg tgctggtgca cgccggctcc cagggccaga gctcagccct gctccacccc     2340



tctccgacca accagcaggc ctcgcctgtg atccactact cacccaccaa ccagcagctg     2400



cgctgcggaa gccaccagga gttccagcac atcatgtact gcgagaattt cgcaccaggc     2460



accaccagac ctggcccgcc cccggtcagt caaggtcaga ggctgagccc gggttcctac     2520



cccacagtca ttcagcagca gaatgccacg agccaaagag ccgccaaaaa cggacccccg     2580



gtcagtgacc aaaaggaagt attacctgcg ggggtgacca ttaaacagga gcagaacttg     2640



gaccagacct acttggatga tgagctgata gacacacacc ttagctggat acaaaacata     2700



ttatgaaaca gaatgactgt gatctttgat ccgagaaatc aaagttaaag ttaatgaaat     2760



tatcaggaag gagttttcag gacctcctgc cagaaatcag acgtaaaaga agccattata     2820



gcaagacacc ttctgtatct gacccctcgg agccctccac agcccctcac cttctgtctc     2880



ctttcatgtt catctcccag cccggagtcc acacgcggat caatgtatgg gcactaagcg     2940



gactctcact taaggagctc gccacctccc tcta                                 2974





<210>  90

<211>  901

<212>  PRT

<213>  Homo sapiens



<400>  90



Met Gln Arg Glu Ala Ala Phe Arg Leu Gly His Cys His Pro Leu Arg 

1               5                   10                  15      





Ile Met Gly Ser Val Asp Gln Glu Glu Pro Asn Ala His Lys Val Ala 

            20                  25                  30          





Ser Pro Pro Ser Gly Pro Ala Tyr Pro Asp Asp Val Leu Asp Tyr Gly 

        35                  40                  45              





Leu Lys Pro Tyr Ser Pro Leu Ala Ser Leu Ser Gly Glu Pro Pro Gly 

    50                  55                  60                  





Arg Phe Gly Glu Pro Asp Arg Val Gly Pro Gln Lys Phe Leu Ser Ala 

65                  70                  75                  80  





Ala Lys Pro Ala Gly Ala Ser Gly Leu Ser Pro Arg Ile Glu Ile Thr 

                85                  90                  95      





Pro Ser His Glu Leu Ile Gln Ala Val Gly Pro Leu Arg Met Arg Asp 

            100                 105                 110         





Ala Gly Leu Leu Val Glu Gln Pro Pro Leu Ala Gly Val Ala Ala Ser 

        115                 120                 125             





Pro Arg Phe Thr Leu Pro Val Pro Gly Phe Glu Gly Tyr Arg Glu Pro 

    130                 135                 140                 





Leu Cys Leu Ser Pro Ala Ser Ser Gly Ser Ser Ala Ser Phe Ile Ser 

145                 150                 155                 160 





Asp Thr Phe Ser Pro Tyr Thr Ser Pro Cys Val Ser Pro Asn Asn Gly 

                165                 170                 175     





Gly Pro Asp Asp Leu Cys Pro Gln Phe Gln Asn Ile Pro Ala His Tyr 

            180                 185                 190         





Ser Pro Arg Thr Ser Pro Ile Met Ser Pro Arg Thr Ser Leu Ala Glu 

        195                 200                 205             





Asp Ser Cys Leu Gly Arg His Ser Pro Val Pro Arg Pro Ala Ser Arg 

    210                 215                 220                 





Ser Ser Ser Pro Gly Ala Lys Arg Arg His Ser Cys Ala Glu Ala Leu 

225                 230                 235                 240 





Val Ala Leu Pro Pro Gly Ala Ser Pro Gln Arg Ser Arg Ser Pro Ser 

                245                 250                 255     





Pro Gln Pro Ser Ser His Val Ala Pro Gln Asp His Gly Ser Pro Ala 

            260                 265                 270         





Gly Tyr Pro Pro Val Ala Gly Ser Ala Val Ile Met Asp Ala Leu Asn 

        275                 280                 285             





Ser Leu Ala Thr Asp Ser Pro Cys Gly Ile Pro Pro Lys Met Trp Lys 

    290                 295                 300                 





Thr Ser Pro Asp Pro Ser Pro Val Ser Ala Ala Pro Ser Lys Ala Gly 

305                 310                 315                 320 





Leu Pro Arg His Ile Tyr Pro Ala Val Glu Phe Leu Gly Pro Cys Glu 

                325                 330                 335     





Gln Gly Glu Arg Arg Asn Ser Ala Pro Glu Ser Ile Leu Leu Val Pro 

            340                 345                 350         





Pro Thr Trp Pro Lys Pro Leu Val Pro Ala Ile Pro Ile Cys Ser Ile 

        355                 360                 365             





Pro Val Thr Ala Ser Leu Pro Pro Leu Glu Trp Pro Leu Ser Ser Gln 

    370                 375                 380                 





Ser Gly Ser Tyr Glu Leu Arg Ile Glu Val Gln Pro Lys Pro His His 

385                 390                 395                 400 





Arg Ala His Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Pro 

                405                 410                 415     





Thr Gly Gly His Pro Val Val Gln Leu His Gly Tyr Met Glu Asn Lys 

            420                 425                 430         





Pro Leu Gly Leu Gln Ile Phe Ile Gly Thr Ala Asp Glu Arg Ile Leu 

        435                 440                 445             





Lys Pro His Ala Phe Tyr Gln Val His Arg Ile Thr Gly Lys Thr Val 

    450                 455                 460                 





Thr Thr Thr Ser Tyr Glu Lys Ile Val Gly Asn Thr Lys Val Leu Glu 

465                 470                 475                 480 





Ile Pro Leu Glu Pro Lys Asn Asn Met Arg Ala Thr Ile Asp Cys Ala 

                485                 490                 495     





Gly Ile Leu Lys Leu Arg Asn Ala Asp Ile Glu Leu Arg Lys Gly Glu 

            500                 505                 510         





Thr Asp Ile Gly Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val 

        515                 520                 525             





His Ile Pro Glu Ser Ser Gly Arg Ile Val Ser Leu Gln Thr Ala Ser 

    530                 535                 540                 





Asn Pro Ile Glu Cys Ser Gln Arg Ser Ala His Glu Leu Pro Met Val 

545                 550                 555                 560 





Glu Arg Gln Asp Thr Asp Ser Cys Leu Val Tyr Gly Gly Gln Gln Met 

                565                 570                 575     





Ile Leu Thr Gly Gln Asn Phe Thr Ser Glu Ser Lys Val Val Phe Thr 

            580                 585                 590         





Glu Lys Thr Thr Asp Gly Gln Gln Ile Trp Glu Met Glu Ala Thr Val 

        595                 600                 605             





Asp Lys Asp Lys Ser Gln Pro Asn Met Leu Phe Val Glu Ile Pro Glu 

    610                 615                 620                 





Tyr Arg Asn Lys His Ile Arg Thr Pro Val Lys Val Asn Phe Tyr Val 

625                 630                 635                 640 





Ile Asn Gly Lys Arg Lys Arg Ser Gln Pro Gln His Phe Thr Tyr His 

                645                 650                 655     





Pro Val Pro Ala Ile Lys Thr Glu Pro Thr Asp Glu Tyr Asp Pro Thr 

            660                 665                 670         





Leu Ile Cys Ser Pro Thr His Gly Gly Leu Gly Ser Gln Pro Tyr Tyr 

        675                 680                 685             





Pro Gln His Pro Met Val Ala Glu Ser Pro Ser Cys Leu Val Ala Thr 

    690                 695                 700                 





Met Ala Pro Cys Gln Gln Phe Arg Thr Gly Leu Ser Ser Pro Asp Ala 

705                 710                 715                 720 





Arg Tyr Gln Gln Gln Asn Pro Ala Ala Val Leu Tyr Gln Arg Ser Lys 

                725                 730                 735     





Ser Leu Ser Pro Ser Leu Leu Gly Tyr Gln Gln Pro Ala Leu Met Ala 

            740                 745                 750         





Ala Pro Leu Ser Leu Ala Asp Ala His Arg Ser Val Leu Val His Ala 

        755                 760                 765             





Gly Ser Gln Gly Gln Ser Ser Ala Leu Leu His Pro Ser Pro Thr Asn 

    770                 775                 780                 





Gln Gln Ala Ser Pro Val Ile His Tyr Ser Pro Thr Asn Gln Gln Leu 

785                 790                 795                 800 





Arg Cys Gly Ser His Gln Glu Phe Gln His Ile Met Tyr Cys Glu Asn 

                805                 810                 815     





Phe Ala Pro Gly Thr Thr Arg Pro Gly Pro Pro Pro Val Ser Gln Gly 

            820                 825                 830         





Gln Arg Leu Ser Pro Gly Ser Tyr Pro Thr Val Ile Gln Gln Gln Asn 

        835                 840                 845             





Ala Thr Ser Gln Arg Ala Ala Lys Asn Gly Pro Pro Val Ser Asp Gln 

    850                 855                 860                 





Lys Glu Val Leu Pro Ala Gly Val Thr Ile Lys Gln Glu Gln Asn Leu 

865                 870                 875                 880 





Asp Gln Thr Tyr Leu Asp Asp Glu Leu Ile Asp Thr His Leu Ser Trp 

                885                 890                 895     





Ile Gln Asn Ile Leu 

            900     





<210>  91

<211>  3254

<212>  DNA

<213>  Homo sapiens



<400>  91

agcaggaagc tcgcgccgcc gtcgccgccg ccgctcagct tccccgggcg cgtccaggac       60



ccgctgcgcc aggcgcgccg tccccggacc cggcgtgcgt ccctacgagg aaagggaccc      120



cgccgctcga gccgcctccg ccagccccac tgcgaggggt cccagagcca gccgcgcccg      180



ccctcgcccc cggccccgca gccttcccgc cctgcgcgcc atgaacgccc ccgagcggca      240



gccccaaccc gacggcgggg acgccccagg ccacgagcct gggggcagcc cccaagacga      300



gcttgacttc tccatcctct tcgactatga gtatttgaat ccgaacgaag aagagccgaa      360



tgcacataag gtcgccagcc caccctccgg acccgcatac cccgatgatg tcctggacta      420



tggcctcaag ccatacagcc cccttgctag tctctctggc gagccccccg gccgattcgg      480



agagccggat agggtagggc cgcagaagtt tctgagcgcg gccaagccag caggggcctc      540



gggcctgagc cctcggatcg agatcactcc gtcccacgaa ctgatccagg cagtggggcc      600



cctccgcatg agagacgcgg gcctcctggt ggagcagccg cccctggccg gggtggccgc      660



cagcccgagg ttcaccctgc ccgtgcccgg cttcgagggc taccgcgagc cgctttgctt      720



gagccccgct agcagcggct cctctgccag cttcatttct gacaccttct ccccctacac      780



ctcgccctgc gtctcgccca ataacggcgg gcccgacgac ctgtgtccgc agtttcaaaa      840



catccctgct cattattccc ccagaacctc gccaataatg tcacctcgaa ccagcctcgc      900



cgaggacagc tgcctgggcc gccactcgcc cgtgccccgt ccggcctccc gctcctcatc      960



gcctggtgcc aagcggaggc attcgtgcgc cgaggccttg gttgccctgc cgcccggagc     1020



ctcaccccag cgctcccgga gcccctcgcc gcagccctca tctcacgtgg caccccagga     1080



ccacggctcc ccggctgggt acccccctgt ggctggctct gccgtgatca tggatgccct     1140



gaacagcctc gccacggact cgccttgtgg gatccccccc aagatgtgga agaccagccc     1200



tgacccctcg ccggtgtctg ccgccccatc caaggccggc ctgcctcgcc acatctaccc     1260



ggccgtggag ttcctggggc cctgcgagca gggcgagagg agaaactcgg ctccagaatc     1320



catcctgctg gttccgccca cttggcccaa gccgctggtg cctgccattc ccatctgcag     1380



catcccagtg actgcatccc tccctccact tgagtggccg ctgtccagtc agtcaggctc     1440



ttacgagctg cggatcgagg tgcagcccaa gccacatcac cgggcccact atgagacaga     1500



aggcagccga ggggctgtca aagctccaac tggaggccac cctgtggttc agctccatgg     1560



ctacatggaa aacaagcctc tgggacttca gatcttcatt gggacagctg atgagcggat     1620



ccttaagccg cacgccttct accaggtgca ccgaatcacg gggaaaactg tcaccaccac     1680



cagctatgag aagatagtgg gcaacaccaa agtcctggag atacccttgg agcccaaaaa     1740



caacatgagg gcaaccatcg actgtgcggg gatcttgaag cttagaaacg ccgacattga     1800



gctgcggaaa ggcgagacgg acattggaag aaagaacacg cgggtgagac tggttttccg     1860



agttcacatc ccagagtcca gtggcagaat cgtctcttta cagactgcat ctaaccccat     1920



cgagtgctcc cagcgatctg ctcacgagct gcccatggtt gaaagacaag acacagacag     1980



ctgcctggtc tatggcggcc agcaaatgat cctcacgggg cagaacttta catccgagtc     2040



caaagttgtg tttactgaga agaccacaga tggacagcaa atttgggaga tggaagccac     2100



ggtggataag gacaagagcc agcccaacat gctttttgtt gagatccctg aatatcggaa     2160



caagcatatc cgcacacctg taaaagtgaa cttctacgtc atcaatggga agagaaaacg     2220



aagtcagcct cagcacttta cctaccaccc agtcccagcc atcaagacgg agcccacgga     2280



tgaatatgac cccactctga tctgcagccc cacccatgga ggcctgggga gccagcctta     2340



ctacccccag cacccgatgg tggccgagtc cccctcctgc ctcgtggcca ccatggctcc     2400



ctgccagcag ttccgcacgg ggctctcatc ccctgacgcc cgctaccagc aacagaaccc     2460



agcggccgta ctctaccagc ggagcaagag cctgagcccc agcctgctgg gctatcagca     2520



gccggccctc atggccgccc cgctgtccct tgcggacgct caccgctctg tgctggtgca     2580



cgccggctcc cagggccaga gctcagccct gctccacccc tctccgacca accagcaggc     2640



ctcgcctgtg atccactact cacccaccaa ccagcagctg cgctgcggaa gccaccagga     2700



gttccagcac atcatgtact gcgagaattt cgcaccaggc accaccagac ctggcccgcc     2760



cccggtcagt caaggtcaga ggctgagccc gggttcctac cccacagtca ttcagcagca     2820



gaatgccacg agccaaagag ccgccaaaaa cggacccccg gtcagtgacc aaaaggaagt     2880



attacctgcg ggggtgacca ttaaacagga gcagaacttg gaccagacct acttggatga     2940



tgagctgata gacacacacc ttagctggat acaaaacata ttatgaaaca gaatgactgt     3000



gatctttgat ccgagaaatc aaagttaaag ttaatgaaat tatcaggaag gagttttcag     3060



gacctcctgc cagaaatcag acgtaaaaga agccattata gcaagacacc ttctgtatct     3120



gacccctcgg agccctccac agcccctcac cttctgtctc ctttcatgtt catctcccag     3180



cccggagtcc acacgcggat caatgtatgg gcactaagcg gactctcact taaggagctc     3240



gccacctccc tcta                                                       3254





<210>  92

<211>  921

<212>  PRT

<213>  Homo sapiens



<400>  92



Met Asn Ala Pro Glu Arg Gln Pro Gln Pro Asp Gly Gly Asp Ala Pro 

1               5                   10                  15      





Gly His Glu Pro Gly Gly Ser Pro Gln Asp Glu Leu Asp Phe Ser Ile 

            20                  25                  30          





Leu Phe Asp Tyr Glu Tyr Leu Asn Pro Asn Glu Glu Glu Pro Asn Ala 

        35                  40                  45              





His Lys Val Ala Ser Pro Pro Ser Gly Pro Ala Tyr Pro Asp Asp Val 

    50                  55                  60                  





Leu Asp Tyr Gly Leu Lys Pro Tyr Ser Pro Leu Ala Ser Leu Ser Gly 

65                  70                  75                  80  





Glu Pro Pro Gly Arg Phe Gly Glu Pro Asp Arg Val Gly Pro Gln Lys 

                85                  90                  95      





Phe Leu Ser Ala Ala Lys Pro Ala Gly Ala Ser Gly Leu Ser Pro Arg 

            100                 105                 110         





Ile Glu Ile Thr Pro Ser His Glu Leu Ile Gln Ala Val Gly Pro Leu 

        115                 120                 125             





Arg Met Arg Asp Ala Gly Leu Leu Val Glu Gln Pro Pro Leu Ala Gly 

    130                 135                 140                 





Val Ala Ala Ser Pro Arg Phe Thr Leu Pro Val Pro Gly Phe Glu Gly 

145                 150                 155                 160 





Tyr Arg Glu Pro Leu Cys Leu Ser Pro Ala Ser Ser Gly Ser Ser Ala 

                165                 170                 175     





Ser Phe Ile Ser Asp Thr Phe Ser Pro Tyr Thr Ser Pro Cys Val Ser 

            180                 185                 190         





Pro Asn Asn Gly Gly Pro Asp Asp Leu Cys Pro Gln Phe Gln Asn Ile 

        195                 200                 205             





Pro Ala His Tyr Ser Pro Arg Thr Ser Pro Ile Met Ser Pro Arg Thr 

    210                 215                 220                 





Ser Leu Ala Glu Asp Ser Cys Leu Gly Arg His Ser Pro Val Pro Arg 

225                 230                 235                 240 





Pro Ala Ser Arg Ser Ser Ser Pro Gly Ala Lys Arg Arg His Ser Cys 

                245                 250                 255     





Ala Glu Ala Leu Val Ala Leu Pro Pro Gly Ala Ser Pro Gln Arg Ser 

            260                 265                 270         





Arg Ser Pro Ser Pro Gln Pro Ser Ser His Val Ala Pro Gln Asp His 

        275                 280                 285             





Gly Ser Pro Ala Gly Tyr Pro Pro Val Ala Gly Ser Ala Val Ile Met 

    290                 295                 300                 





Asp Ala Leu Asn Ser Leu Ala Thr Asp Ser Pro Cys Gly Ile Pro Pro 

305                 310                 315                 320 





Lys Met Trp Lys Thr Ser Pro Asp Pro Ser Pro Val Ser Ala Ala Pro 

                325                 330                 335     





Ser Lys Ala Gly Leu Pro Arg His Ile Tyr Pro Ala Val Glu Phe Leu 

            340                 345                 350         





Gly Pro Cys Glu Gln Gly Glu Arg Arg Asn Ser Ala Pro Glu Ser Ile 

        355                 360                 365             





Leu Leu Val Pro Pro Thr Trp Pro Lys Pro Leu Val Pro Ala Ile Pro 

    370                 375                 380                 





Ile Cys Ser Ile Pro Val Thr Ala Ser Leu Pro Pro Leu Glu Trp Pro 

385                 390                 395                 400 





Leu Ser Ser Gln Ser Gly Ser Tyr Glu Leu Arg Ile Glu Val Gln Pro 

                405                 410                 415     





Lys Pro His His Arg Ala His Tyr Glu Thr Glu Gly Ser Arg Gly Ala 

            420                 425                 430         





Val Lys Ala Pro Thr Gly Gly His Pro Val Val Gln Leu His Gly Tyr 

        435                 440                 445             





Met Glu Asn Lys Pro Leu Gly Leu Gln Ile Phe Ile Gly Thr Ala Asp 

    450                 455                 460                 





Glu Arg Ile Leu Lys Pro His Ala Phe Tyr Gln Val His Arg Ile Thr 

465                 470                 475                 480 





Gly Lys Thr Val Thr Thr Thr Ser Tyr Glu Lys Ile Val Gly Asn Thr 

                485                 490                 495     





Lys Val Leu Glu Ile Pro Leu Glu Pro Lys Asn Asn Met Arg Ala Thr 

            500                 505                 510         





Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn Ala Asp Ile Glu Leu 

        515                 520                 525             





Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn Thr Arg Val Arg Leu 

    530                 535                 540                 





Val Phe Arg Val His Ile Pro Glu Ser Ser Gly Arg Ile Val Ser Leu 

545                 550                 555                 560 





Gln Thr Ala Ser Asn Pro Ile Glu Cys Ser Gln Arg Ser Ala His Glu 

                565                 570                 575     





Leu Pro Met Val Glu Arg Gln Asp Thr Asp Ser Cys Leu Val Tyr Gly 

            580                 585                 590         





Gly Gln Gln Met Ile Leu Thr Gly Gln Asn Phe Thr Ser Glu Ser Lys 

        595                 600                 605             





Val Val Phe Thr Glu Lys Thr Thr Asp Gly Gln Gln Ile Trp Glu Met 

    610                 615                 620                 





Glu Ala Thr Val Asp Lys Asp Lys Ser Gln Pro Asn Met Leu Phe Val 

625                 630                 635                 640 





Glu Ile Pro Glu Tyr Arg Asn Lys His Ile Arg Thr Pro Val Lys Val 

                645                 650                 655     





Asn Phe Tyr Val Ile Asn Gly Lys Arg Lys Arg Ser Gln Pro Gln His 

            660                 665                 670         





Phe Thr Tyr His Pro Val Pro Ala Ile Lys Thr Glu Pro Thr Asp Glu 

        675                 680                 685             





Tyr Asp Pro Thr Leu Ile Cys Ser Pro Thr His Gly Gly Leu Gly Ser 

    690                 695                 700                 





Gln Pro Tyr Tyr Pro Gln His Pro Met Val Ala Glu Ser Pro Ser Cys 

705                 710                 715                 720 





Leu Val Ala Thr Met Ala Pro Cys Gln Gln Phe Arg Thr Gly Leu Ser 

                725                 730                 735     





Ser Pro Asp Ala Arg Tyr Gln Gln Gln Asn Pro Ala Ala Val Leu Tyr 

            740                 745                 750         





Gln Arg Ser Lys Ser Leu Ser Pro Ser Leu Leu Gly Tyr Gln Gln Pro 

        755                 760                 765             





Ala Leu Met Ala Ala Pro Leu Ser Leu Ala Asp Ala His Arg Ser Val 

    770                 775                 780                 





Leu Val His Ala Gly Ser Gln Gly Gln Ser Ser Ala Leu Leu His Pro 

785                 790                 795                 800 





Ser Pro Thr Asn Gln Gln Ala Ser Pro Val Ile His Tyr Ser Pro Thr 

                805                 810                 815     





Asn Gln Gln Leu Arg Cys Gly Ser His Gln Glu Phe Gln His Ile Met 

            820                 825                 830         





Tyr Cys Glu Asn Phe Ala Pro Gly Thr Thr Arg Pro Gly Pro Pro Pro 

        835                 840                 845             





Val Ser Gln Gly Gln Arg Leu Ser Pro Gly Ser Tyr Pro Thr Val Ile 

    850                 855                 860                 





Gln Gln Gln Asn Ala Thr Ser Gln Arg Ala Ala Lys Asn Gly Pro Pro 

865                 870                 875                 880 





Val Ser Asp Gln Lys Glu Val Leu Pro Ala Gly Val Thr Ile Lys Gln 

                885                 890                 895     





Glu Gln Asn Leu Asp Gln Thr Tyr Leu Asp Asp Glu Leu Ile Asp Thr 

            900                 905                 910         





His Leu Ser Trp Ile Gln Asn Ile Leu 

        915                 920     





<210>  93

<211>  3166

<212>  DNA

<213>  Homo sapiens



<400>  93

agcaggaagc tcgcgccgcc gtcgccgccg ccgctcagct tccccgggcg cgtccaggac       60



ccgctgcgcc aggcgcgccg tccccggacc cggcgtgcgt ccctacgagg aaagggaccc      120



cgccgctcga gccgcctccg ccagccccac tgcgaggggt cccagagcca gccgcgcccg      180



ccctcgcccc cggccccgca gccttcccgc cctgcgcgcc atgaacgccc ccgagcggca      240



gccccaaccc gacggcgggg acgccccagg ccacgagcct gggggcagcc cccaagacga      300



gcttgacttc tccatcctct tcgactatga gtatttgaat ccgaacgaag aagagccgaa      360



tgcacataag gtcgccagcc caccctccgg acccgcatac cccgatgatg tcctggacta      420



tggcctcaag ccatacagcc cccttgctag tctctctggc gagccccccg gccgattcgg      480



agagccggat agggtagggc cgcagaagtt tctgagcgcg gccaagccag caggggcctc      540



gggcctgagc cctcggatcg agatcactcc gtcccacgaa ctgatccagg cagtggggcc      600



cctccgcatg agagacgcgg gcctcctggt ggagcagccg cccctggccg gggtggccgc      660



cagcccgagg ttcaccctgc ccgtgcccgg cttcgagggc taccgcgagc cgctttgctt      720



gagccccgct agcagcggct cctctgccag cttcatttct gacaccttct ccccctacac      780



ctcgccctgc gtctcgccca ataacggcgg gcccgacgac ctgtgtccgc agtttcaaaa      840



catccctgct cattattccc ccagaacctc gccaataatg tcacctcgaa ccagcctcgc      900



cgaggacagc tgcctgggcc gccactcgcc cgtgccccgt ccggcctccc gctcctcatc      960



gcctggtgcc aagcggaggc attcgtgcgc cgaggccttg gttgccctgc cgcccggagc     1020



ctcaccccag cgctcccgga gcccctcgcc gcagccctca tctcacgtgg caccccagga     1080



ccacggctcc ccggctgggt acccccctgt ggctggctct gccgtgatca tggatgccct     1140



gaacagcctc gccacggact cgccttgtgg gatccccccc aagatgtgga agaccagccc     1200



tgacccctcg ccggtgtctg ccgccccatc caaggccggc ctgcctcgcc acatctaccc     1260



ggccgtggag ttcctggggc cctgcgagca gggcgagagg agaaactcgg ctccagaatc     1320



catcctgctg gttccgccca cttggcccaa gccgctggtg cctgccattc ccatctgcag     1380



catcccagtg actgcatccc tccctccact tgagtggccg ctgtccagtc agtcaggctc     1440



ttacgagctg cggatcgagg tgcagcccaa gccacatcac cgggcccact atgagacaga     1500



aggcagccga ggggctgtca aagctccaac tggaggccac cctgtggttc agctccatgg     1560



ctacatggaa aacaagcctc tgggacttca gatcttcatt gggacagctg atgagcggat     1620



ccttaagccg cacgccttct accaggtgca ccgaatcacg gggaaaactg tcaccaccac     1680



cagctatgag aagatagtgg gcaacaccaa agtcctggag atacccttgg agcccaaaaa     1740



caacatgagg gcaaccatcg actgtgcggg gatcttgaag cttagaaacg ccgacattga     1800



gctgcggaaa ggcgagacgg acattggaag aaagaacacg cgggtgagac tggttttccg     1860



agttcacatc ccagagtcca gtggcagaat cgtctcttta cagactgcat ctaaccccat     1920



cgagtgctcc cagcgatctg ctcacgagct gcccatggtt gaaagacaag acacagacag     1980



ctgcctggtc tatggcggcc agcaaatgat cctcacgggg cagaacttta catccgagtc     2040



caaagttgtg tttactgaga agaccacaga tggacagcaa atttgggaga tggaagccac     2100



ggtggataag gacaagagcc agcccaacat gctttttgtt gagatccctg aatatcggaa     2160



caagcatatc cgcacacctg taaaagtgaa cttctacgtc atcaatggga agagaaaacg     2220



aagtcagcct cagcacttta cctaccaccc agtcccagcc atcaagacgg agcccacgga     2280



tgaatatgac cccactctga tctgcagccc cacccatgga ggcctgggga gccagcctta     2340



ctacccccag cacccgatgg tggccgagtc cccctcctgc ctcgtggcca ccatggctcc     2400



ctgccagcag ttccgcacgg ggctctcatc ccctgacgcc cgctaccagc aacagaaccc     2460



agcggccgta ctctaccagc ggagcaagag cctgagcccc agcctgctgg gctatcagca     2520



gccggccctc atggccgccc cgctgtccct tgcggacgct caccgctctg tgctggtgca     2580



cgccggctcc cagggccaga gctcagccct gctccacccc tctccgacca accagcaggc     2640



ctcgcctgtg atccactact cacccaccaa ccagcagctg cgctgcggaa gccaccagga     2700



gttccagcac atcatgtact gcgagaattt cgcaccaggc accaccagac ctggcccgcc     2760



cccggtcagt caaggtcaga ggctgagccc gggttcctac cccacagtca ttcagcagca     2820



gaatgccacg agccaaagag ccgccaaaaa cggacccccg gtcagtgacc aaaaggaagt     2880



attacctgcg ggggtgacca ttaaacagga gcagaacttg gaccagacct acttggatga     2940



tgttaatgaa attatcagga aggagttttc aggacctcct gccagaaatc agacgtaaaa     3000



gaagccatta tagcaagaca ccttctgtat ctgacccctc ggagccctcc acagcccctc     3060



accttctgtc tcctttcatg ttcatctccc agcccggagt ccacacgcgg atcaatgtat     3120



gggcactaag cggactctca cttaaggagc tcgccacctc cctcta                    3166





<210>  94

<211>  925

<212>  PRT

<213>  Homo sapiens



<400>  94



Met Asn Ala Pro Glu Arg Gln Pro Gln Pro Asp Gly Gly Asp Ala Pro 

1               5                   10                  15      





Gly His Glu Pro Gly Gly Ser Pro Gln Asp Glu Leu Asp Phe Ser Ile 

            20                  25                  30          





Leu Phe Asp Tyr Glu Tyr Leu Asn Pro Asn Glu Glu Glu Pro Asn Ala 

        35                  40                  45              





His Lys Val Ala Ser Pro Pro Ser Gly Pro Ala Tyr Pro Asp Asp Val 

    50                  55                  60                  





Leu Asp Tyr Gly Leu Lys Pro Tyr Ser Pro Leu Ala Ser Leu Ser Gly 

65                  70                  75                  80  





Glu Pro Pro Gly Arg Phe Gly Glu Pro Asp Arg Val Gly Pro Gln Lys 

                85                  90                  95      





Phe Leu Ser Ala Ala Lys Pro Ala Gly Ala Ser Gly Leu Ser Pro Arg 

            100                 105                 110         





Ile Glu Ile Thr Pro Ser His Glu Leu Ile Gln Ala Val Gly Pro Leu 

        115                 120                 125             





Arg Met Arg Asp Ala Gly Leu Leu Val Glu Gln Pro Pro Leu Ala Gly 

    130                 135                 140                 





Val Ala Ala Ser Pro Arg Phe Thr Leu Pro Val Pro Gly Phe Glu Gly 

145                 150                 155                 160 





Tyr Arg Glu Pro Leu Cys Leu Ser Pro Ala Ser Ser Gly Ser Ser Ala 

                165                 170                 175     





Ser Phe Ile Ser Asp Thr Phe Ser Pro Tyr Thr Ser Pro Cys Val Ser 

            180                 185                 190         





Pro Asn Asn Gly Gly Pro Asp Asp Leu Cys Pro Gln Phe Gln Asn Ile 

        195                 200                 205             





Pro Ala His Tyr Ser Pro Arg Thr Ser Pro Ile Met Ser Pro Arg Thr 

    210                 215                 220                 





Ser Leu Ala Glu Asp Ser Cys Leu Gly Arg His Ser Pro Val Pro Arg 

225                 230                 235                 240 





Pro Ala Ser Arg Ser Ser Ser Pro Gly Ala Lys Arg Arg His Ser Cys 

                245                 250                 255     





Ala Glu Ala Leu Val Ala Leu Pro Pro Gly Ala Ser Pro Gln Arg Ser 

            260                 265                 270         





Arg Ser Pro Ser Pro Gln Pro Ser Ser His Val Ala Pro Gln Asp His 

        275                 280                 285             





Gly Ser Pro Ala Gly Tyr Pro Pro Val Ala Gly Ser Ala Val Ile Met 

    290                 295                 300                 





Asp Ala Leu Asn Ser Leu Ala Thr Asp Ser Pro Cys Gly Ile Pro Pro 

305                 310                 315                 320 





Lys Met Trp Lys Thr Ser Pro Asp Pro Ser Pro Val Ser Ala Ala Pro 

                325                 330                 335     





Ser Lys Ala Gly Leu Pro Arg His Ile Tyr Pro Ala Val Glu Phe Leu 

            340                 345                 350         





Gly Pro Cys Glu Gln Gly Glu Arg Arg Asn Ser Ala Pro Glu Ser Ile 

        355                 360                 365             





Leu Leu Val Pro Pro Thr Trp Pro Lys Pro Leu Val Pro Ala Ile Pro 

    370                 375                 380                 





Ile Cys Ser Ile Pro Val Thr Ala Ser Leu Pro Pro Leu Glu Trp Pro 

385                 390                 395                 400 





Leu Ser Ser Gln Ser Gly Ser Tyr Glu Leu Arg Ile Glu Val Gln Pro 

                405                 410                 415     





Lys Pro His His Arg Ala His Tyr Glu Thr Glu Gly Ser Arg Gly Ala 

            420                 425                 430         





Val Lys Ala Pro Thr Gly Gly His Pro Val Val Gln Leu His Gly Tyr 

        435                 440                 445             





Met Glu Asn Lys Pro Leu Gly Leu Gln Ile Phe Ile Gly Thr Ala Asp 

    450                 455                 460                 





Glu Arg Ile Leu Lys Pro His Ala Phe Tyr Gln Val His Arg Ile Thr 

465                 470                 475                 480 





Gly Lys Thr Val Thr Thr Thr Ser Tyr Glu Lys Ile Val Gly Asn Thr 

                485                 490                 495     





Lys Val Leu Glu Ile Pro Leu Glu Pro Lys Asn Asn Met Arg Ala Thr 

            500                 505                 510         





Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn Ala Asp Ile Glu Leu 

        515                 520                 525             





Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn Thr Arg Val Arg Leu 

    530                 535                 540                 





Val Phe Arg Val His Ile Pro Glu Ser Ser Gly Arg Ile Val Ser Leu 

545                 550                 555                 560 





Gln Thr Ala Ser Asn Pro Ile Glu Cys Ser Gln Arg Ser Ala His Glu 

                565                 570                 575     





Leu Pro Met Val Glu Arg Gln Asp Thr Asp Ser Cys Leu Val Tyr Gly 

            580                 585                 590         





Gly Gln Gln Met Ile Leu Thr Gly Gln Asn Phe Thr Ser Glu Ser Lys 

        595                 600                 605             





Val Val Phe Thr Glu Lys Thr Thr Asp Gly Gln Gln Ile Trp Glu Met 

    610                 615                 620                 





Glu Ala Thr Val Asp Lys Asp Lys Ser Gln Pro Asn Met Leu Phe Val 

625                 630                 635                 640 





Glu Ile Pro Glu Tyr Arg Asn Lys His Ile Arg Thr Pro Val Lys Val 

                645                 650                 655     





Asn Phe Tyr Val Ile Asn Gly Lys Arg Lys Arg Ser Gln Pro Gln His 

            660                 665                 670         





Phe Thr Tyr His Pro Val Pro Ala Ile Lys Thr Glu Pro Thr Asp Glu 

        675                 680                 685             





Tyr Asp Pro Thr Leu Ile Cys Ser Pro Thr His Gly Gly Leu Gly Ser 

    690                 695                 700                 





Gln Pro Tyr Tyr Pro Gln His Pro Met Val Ala Glu Ser Pro Ser Cys 

705                 710                 715                 720 





Leu Val Ala Thr Met Ala Pro Cys Gln Gln Phe Arg Thr Gly Leu Ser 

                725                 730                 735     





Ser Pro Asp Ala Arg Tyr Gln Gln Gln Asn Pro Ala Ala Val Leu Tyr 

            740                 745                 750         





Gln Arg Ser Lys Ser Leu Ser Pro Ser Leu Leu Gly Tyr Gln Gln Pro 

        755                 760                 765             





Ala Leu Met Ala Ala Pro Leu Ser Leu Ala Asp Ala His Arg Ser Val 

    770                 775                 780                 





Leu Val His Ala Gly Ser Gln Gly Gln Ser Ser Ala Leu Leu His Pro 

785                 790                 795                 800 





Ser Pro Thr Asn Gln Gln Ala Ser Pro Val Ile His Tyr Ser Pro Thr 

                805                 810                 815     





Asn Gln Gln Leu Arg Cys Gly Ser His Gln Glu Phe Gln His Ile Met 

            820                 825                 830         





Tyr Cys Glu Asn Phe Ala Pro Gly Thr Thr Arg Pro Gly Pro Pro Pro 

        835                 840                 845             





Val Ser Gln Gly Gln Arg Leu Ser Pro Gly Ser Tyr Pro Thr Val Ile 

    850                 855                 860                 





Gln Gln Gln Asn Ala Thr Ser Gln Arg Ala Ala Lys Asn Gly Pro Pro 

865                 870                 875                 880 





Val Ser Asp Gln Lys Glu Val Leu Pro Ala Gly Val Thr Ile Lys Gln 

                885                 890                 895     





Glu Gln Asn Leu Asp Gln Thr Tyr Leu Asp Asp Val Asn Glu Ile Ile 

            900                 905                 910         





Arg Lys Glu Phe Ser Gly Pro Pro Ala Arg Asn Gln Thr 

        915                 920                 925 





<210>  95

<211>  4005

<212>  DNA

<213>  Homo sapiens



<400>  95

cggctgcggt tcctggtgct gctcggcgcg cggccagctt tcggaacgga acgctcggcg       60



tcgcgggccc cgcccggaaa gtttgccgtg gagtcgcgac ctcttggccc gcgcggcccg      120



gcatgaagcg gcgttgagga gctgctgccg ccgcttgccg ctgccgccgc cgccgcctga      180



ggaggagctg cagcaccctg ggccacgccg atgactactg caaactgtgg cgcccacgac      240



gagctcgact tcaaactcgt ctttggcgag gacggggcgc cggcgccgcc gcccccgggc      300



tcgcggcctg cagatcttga gccagatgat tgtgcatcca tttacatctt taatgtagat      360



ccacctccat ctactttaac cacaccactt tgcttaccac atcatggatt accgtctcac      420



tcttctgttt tgtcaccatc gtttcagctc caaagtcaca aaaactatga aggaacttgt      480



gagattcctg aatctaaata tagcccatta ggtggtccca aaccctttga gtgcccaagt      540



attcaaatta catctatctc tcctaactgt catcaagaat tagatgcaca tgaagatgac      600



ctacagataa atgacccaga acgggaattt ttggaaaggc cttctagaga tcatctctat      660



cttcctcttg agccatccta ccgggagtct tctcttagtc ctagtcctgc cagcagcatc      720



tcttctagga gttggttctc tgatgcatct tcttgtgaat cgctttcaca tatttatgat      780



gatgtggact cagagttgaa tgaagctgca gcccgattta cccttggatc ccctctgact      840



tctcctggtg gctctccagg gggctgccct ggagaagaaa cttggcatca acagtatgga      900



cttggacact cattatcacc caggcaatct ccttgccact ctcctagatc cagtgtcact      960



gatgagaatt ggctgagccc caggccagcc tcaggaccct catcaaggcc cacatccccc     1020



tgtgggaaac ggaggcactc cagtgctgaa gtttgttatg ctgggtccct ttcaccccat     1080



cactcacctg ttccttcacc tggtcactcc cccaggggaa gtgtgacaga agatacgtgg     1140



ctcaatgctt ctgtccatgg tgggtcaggc cttggccctg cagtttttcc atttcagtac     1200



tgtgtagaga ctgacatccc tctcaaaaca aggaaaactt ctgaagatca agctgccata     1260



ctaccaggaa aattagagct gtgttcagat gaccaaggga gtttatcacc agcccgggag     1320



acttcaatag atgatggcct tggatctcag tatcctttaa agaaagattc atgtggtgat     1380



cagtttcttt cagttccttc accctttacc tggagcaaac caaagcctgg ccacacccct     1440



atatttcgca catcttcatt acctccacta gactggcctt taccagctca ttttggacaa     1500



tgtgaactga aaatagaagt gcaacctaaa actcatcatc gagcccatta tgaaactgaa     1560



ggtagccgag gggcagtaaa agcatctact gggggacatc ctgttgtgaa gctcctgggc     1620



tataacgaaa agccaataaa tctacaaatg tttattggga cagcagatga tcgatattta     1680



cgacctcatg cattttacca ggtgcatcga atcactggga agacagtcgc tactgcaagc     1740



caagagataa taattgccag tacaaaagtt ctggaaattc cacttcttcc tgaaaataat     1800



atgtcagcca gtattgattg tgcaggtatt ttgaaactcc gcaattcaga tatagaactt     1860



cgaaaaggag aaactgatat tggcagaaag aatactagag tacgacttgt gtttcgtgta     1920



cacatcccac agcccagtgg aaaagtcctt tctctgcaga tagcctctat acccgttgag     1980



tgctcccagc ggtctgctca agaacttcct catattgaga agtacagtat caacagttgt     2040



tctgtaaatg gaggtcatga aatggttgtg actggatcta attttcttcc agaatccaaa     2100



atcatttttc ttgaaaaagg acaagatgga cgacctcagt gggaggtaga agggaagata     2160



atcagggaaa aatgtcaagg ggctcacatt gtccttgaag ttcctccata tcataaccca     2220



gcagttacag ctgcagtgca ggtgcacttt tatctttgca atggcaagag gaaaaaaagc     2280



cagtctcaac gttttactta tacaccagtt ttgatgaagc aagaacacag agaagagatt     2340



gatttgtctt cagttccatc tttgcctgtg cctcatcctg ctcagaccca gaggccttcc     2400



tctgattcag ggtgttcaca tgacagtgta ctgtcaggac agagaagttt gatttgctcc     2460



atcccacaaa catatgcatc catggtgacc tcatcccatc tgccacagtt gcagtgtaga     2520



gatgagagtg ttagtaaaga acagcatatg attccttctc caattgtaca ccagcctttt     2580



caagtcacac caacacctcc tgtggggtct tcctatcagc ctatgcaaac taatgttgtg     2640



tacaatggac caacttgtct tcctattaat gctgcctcta gtcaagaatt tgattcagtt     2700



ttgtttcagc aggatgcaac tctttctggt ttagtgaatc ttggctgtca accactgtca     2760



tccataccat ttcattcttc aaattcaggc tcaacaggac atctcttagc ccatacacct     2820



cattctgtgc ataccctgcc tcatctgcaa tcaatgggat atcattgttc aaatacagga     2880



caaagatctc tttcttctcc agtggctgac cagattacag gtcagccttc gtctcagtta     2940



caacctatta catatggtcc ttcacattca gggtctgcta caacagcttc cccagcagct     3000



tctcatccct tggctagttc accgctttct gggccaccat ctcctcagct tcagcctatg     3060



ccttaccaat ctcctagctc aggaactgcc tcatcaccgt ctccagccac cagaatgcat     3120



tctggacagc actcaactca agcacaaagt acgggccagg ggggtctttc tgcaccttca     3180



tccttaatat gtcacagttt gtgtgatcca gcgtcatttc cacctgatgg ggcaactgtg     3240



agcattaaac ctgaaccaga agatcgagag cctaactttg caaccattgg tctgcaggac     3300



atcactttag atgatgacca atttatatct gacttggaac accagccatc aggttcagca     3360



gagaaatggc ctaaccacag tgtgctctca tgtccagctc ctttctggag aatctagagg     3420



tgaacgagat aattgggaga gacatgtccc agatttctgt ttcccaagga gcaggggtga     3480



gcaggcaggc tcccctcccg agtcctgagt ccctggattt aggaagatct gatgggctct     3540



aacagtgctt actgcagcct tgtgtccacc accaacttct cagcatgttt ctctccttgg     3600



accttgggtt tccaactctg cagccttcag gtctggggcc aggagtggga cccaccattt     3660



gtggggaaag tagcattcct ccacctcagg ccttgggtag atttggcaaa agaacaggag     3720



cagcataggc tgtttgagct ttggggaaat gaactttgct ttttatattt aactaggata     3780



cttttatatg atgggtgctt tgagtgtgaa tgcagcaggc tctcttgttt ccgaggtgct     3840



gcttttgcag gtgacctggt tacttagcta ggattggtga tttgtactgc tttatggtca     3900



tttgaagggc cctttagttt ttatgataat ttttaaaata ggaacttttg ataagacctt     3960



ctagaagcaa aaaaaaaaaa aaaaaaaaaa aaaagaaaaa aaaag                     4005





<210>  96

<211>  1068

<212>  PRT

<213>  Homo sapiens



<400>  96



Met Thr Thr Ala Asn Cys Gly Ala His Asp Glu Leu Asp Phe Lys Leu 

1               5                   10                  15      





Val Phe Gly Glu Asp Gly Ala Pro Ala Pro Pro Pro Pro Gly Ser Arg 

            20                  25                  30          





Pro Ala Asp Leu Glu Pro Asp Asp Cys Ala Ser Ile Tyr Ile Phe Asn 

        35                  40                  45              





Val Asp Pro Pro Pro Ser Thr Leu Thr Thr Pro Leu Cys Leu Pro His 

    50                  55                  60                  





His Gly Leu Pro Ser His Ser Ser Val Leu Ser Pro Ser Phe Gln Leu 

65                  70                  75                  80  





Gln Ser His Lys Asn Tyr Glu Gly Thr Cys Glu Ile Pro Glu Ser Lys 

                85                  90                  95      





Tyr Ser Pro Leu Gly Gly Pro Lys Pro Phe Glu Cys Pro Ser Ile Gln 

            100                 105                 110         





Ile Thr Ser Ile Ser Pro Asn Cys His Gln Glu Leu Asp Ala His Glu 

        115                 120                 125             





Asp Asp Leu Gln Ile Asn Asp Pro Glu Arg Glu Phe Leu Glu Arg Pro 

    130                 135                 140                 





Ser Arg Asp His Leu Tyr Leu Pro Leu Glu Pro Ser Tyr Arg Glu Ser 

145                 150                 155                 160 





Ser Leu Ser Pro Ser Pro Ala Ser Ser Ile Ser Ser Arg Ser Trp Phe 

                165                 170                 175     





Ser Asp Ala Ser Ser Cys Glu Ser Leu Ser His Ile Tyr Asp Asp Val 

            180                 185                 190         





Asp Ser Glu Leu Asn Glu Ala Ala Ala Arg Phe Thr Leu Gly Ser Pro 

        195                 200                 205             





Leu Thr Ser Pro Gly Gly Ser Pro Gly Gly Cys Pro Gly Glu Glu Thr 

    210                 215                 220                 





Trp His Gln Gln Tyr Gly Leu Gly His Ser Leu Ser Pro Arg Gln Ser 

225                 230                 235                 240 





Pro Cys His Ser Pro Arg Ser Ser Val Thr Asp Glu Asn Trp Leu Ser 

                245                 250                 255     





Pro Arg Pro Ala Ser Gly Pro Ser Ser Arg Pro Thr Ser Pro Cys Gly 

            260                 265                 270         





Lys Arg Arg His Ser Ser Ala Glu Val Cys Tyr Ala Gly Ser Leu Ser 

        275                 280                 285             





Pro His His Ser Pro Val Pro Ser Pro Gly His Ser Pro Arg Gly Ser 

    290                 295                 300                 





Val Thr Glu Asp Thr Trp Leu Asn Ala Ser Val His Gly Gly Ser Gly 

305                 310                 315                 320 





Leu Gly Pro Ala Val Phe Pro Phe Gln Tyr Cys Val Glu Thr Asp Ile 

                325                 330                 335     





Pro Leu Lys Thr Arg Lys Thr Ser Glu Asp Gln Ala Ala Ile Leu Pro 

            340                 345                 350         





Gly Lys Leu Glu Leu Cys Ser Asp Asp Gln Gly Ser Leu Ser Pro Ala 

        355                 360                 365             





Arg Glu Thr Ser Ile Asp Asp Gly Leu Gly Ser Gln Tyr Pro Leu Lys 

    370                 375                 380                 





Lys Asp Ser Cys Gly Asp Gln Phe Leu Ser Val Pro Ser Pro Phe Thr 

385                 390                 395                 400 





Trp Ser Lys Pro Lys Pro Gly His Thr Pro Ile Phe Arg Thr Ser Ser 

                405                 410                 415     





Leu Pro Pro Leu Asp Trp Pro Leu Pro Ala His Phe Gly Gln Cys Glu 

            420                 425                 430         





Leu Lys Ile Glu Val Gln Pro Lys Thr His His Arg Ala His Tyr Glu 

        435                 440                 445             





Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ser Thr Gly Gly His Pro 

    450                 455                 460                 





Val Val Lys Leu Leu Gly Tyr Asn Glu Lys Pro Ile Asn Leu Gln Met 

465                 470                 475                 480 





Phe Ile Gly Thr Ala Asp Asp Arg Tyr Leu Arg Pro His Ala Phe Tyr 

                485                 490                 495     





Gln Val His Arg Ile Thr Gly Lys Thr Val Ala Thr Ala Ser Gln Glu 

            500                 505                 510         





Ile Ile Ile Ala Ser Thr Lys Val Leu Glu Ile Pro Leu Leu Pro Glu 

        515                 520                 525             





Asn Asn Met Ser Ala Ser Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg 

    530                 535                 540                 





Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys 

545                 550                 555                 560 





Asn Thr Arg Val Arg Leu Val Phe Arg Val His Ile Pro Gln Pro Ser 

                565                 570                 575     





Gly Lys Val Leu Ser Leu Gln Ile Ala Ser Ile Pro Val Glu Cys Ser 

            580                 585                 590         





Gln Arg Ser Ala Gln Glu Leu Pro His Ile Glu Lys Tyr Ser Ile Asn 

        595                 600                 605             





Ser Cys Ser Val Asn Gly Gly His Glu Met Val Val Thr Gly Ser Asn 

    610                 615                 620                 





Phe Leu Pro Glu Ser Lys Ile Ile Phe Leu Glu Lys Gly Gln Asp Gly 

625                 630                 635                 640 





Arg Pro Gln Trp Glu Val Glu Gly Lys Ile Ile Arg Glu Lys Cys Gln 

                645                 650                 655     





Gly Ala His Ile Val Leu Glu Val Pro Pro Tyr His Asn Pro Ala Val 

            660                 665                 670         





Thr Ala Ala Val Gln Val His Phe Tyr Leu Cys Asn Gly Lys Arg Lys 

        675                 680                 685             





Lys Ser Gln Ser Gln Arg Phe Thr Tyr Thr Pro Val Leu Met Lys Gln 

    690                 695                 700                 





Glu His Arg Glu Glu Ile Asp Leu Ser Ser Val Pro Ser Leu Pro Val 

705                 710                 715                 720 





Pro His Pro Ala Gln Thr Gln Arg Pro Ser Ser Asp Ser Gly Cys Ser 

                725                 730                 735     





His Asp Ser Val Leu Ser Gly Gln Arg Ser Leu Ile Cys Ser Ile Pro 

            740                 745                 750         





Gln Thr Tyr Ala Ser Met Val Thr Ser Ser His Leu Pro Gln Leu Gln 

        755                 760                 765             





Cys Arg Asp Glu Ser Val Ser Lys Glu Gln His Met Ile Pro Ser Pro 

    770                 775                 780                 





Ile Val His Gln Pro Phe Gln Val Thr Pro Thr Pro Pro Val Gly Ser 

785                 790                 795                 800 





Ser Tyr Gln Pro Met Gln Thr Asn Val Val Tyr Asn Gly Pro Thr Cys 

                805                 810                 815     





Leu Pro Ile Asn Ala Ala Ser Ser Gln Glu Phe Asp Ser Val Leu Phe 

            820                 825                 830         





Gln Gln Asp Ala Thr Leu Ser Gly Leu Val Asn Leu Gly Cys Gln Pro 

        835                 840                 845             





Leu Ser Ser Ile Pro Phe His Ser Ser Asn Ser Gly Ser Thr Gly His 

    850                 855                 860                 





Leu Leu Ala His Thr Pro His Ser Val His Thr Leu Pro His Leu Gln 

865                 870                 875                 880 





Ser Met Gly Tyr His Cys Ser Asn Thr Gly Gln Arg Ser Leu Ser Ser 

                885                 890                 895     





Pro Val Ala Asp Gln Ile Thr Gly Gln Pro Ser Ser Gln Leu Gln Pro 

            900                 905                 910         





Ile Thr Tyr Gly Pro Ser His Ser Gly Ser Ala Thr Thr Ala Ser Pro 

        915                 920                 925             





Ala Ala Ser His Pro Leu Ala Ser Ser Pro Leu Ser Gly Pro Pro Ser 

    930                 935                 940                 





Pro Gln Leu Gln Pro Met Pro Tyr Gln Ser Pro Ser Ser Gly Thr Ala 

945                 950                 955                 960 





Ser Ser Pro Ser Pro Ala Thr Arg Met His Ser Gly Gln His Ser Thr 

                965                 970                 975     





Gln Ala Gln Ser Thr Gly Gln Gly Gly Leu Ser Ala Pro Ser Ser Leu 

            980                 985                 990         





Ile Cys His Ser Leu Cys Asp Pro  Ala Ser Phe Pro Pro  Asp Gly Ala 

        995                 1000                 1005             





Thr Val  Ser Ile Lys Pro Glu  Pro Glu Asp Arg Glu  Pro Asn Phe 

    1010                 1015                 1020             





Ala Thr  Ile Gly Leu Gln Asp  Ile Thr Leu Asp Asp  Asp Gln Phe 

    1025                 1030                 1035             





Ile Ser  Asp Leu Glu His Gln  Pro Ser Gly Ser Ala  Glu Lys Trp 

    1040                 1045                 1050             





Pro Asn  His Ser Val Leu Ser  Cys Pro Ala Pro Phe  Trp Arg Ile 

    1055                 1060                 1065             





<210>  97

<211>  3990

<212>  DNA

<213>  Homo sapiens



<400>  97

cggctgcggt tcctggtgct gctcggcgcg cggccagctt tcggaacgga acgctcggcg       60



tcgcgggccc cgcccggaaa gtttgccgtg gagtcgcgac ctcttggccc gcgcggcccg      120



gcatgaagcg gcgttgagga gctgctgccg ccgcttgccg ctgccgccgc cgccgcctga      180



ggaggagctg cagcaccctg ggccacgccg atgactactg caaactgtgg cgcccacgac      240



gagctcgact tcaaactcgt ctttggcgag gacggggcgc cggcgccgcc gcccccgggc      300



tcgcggcctg cagatcttga gccagatgat tgtgcatcca tttacatctt taatgtagat      360



ccacctccat ctactttaac cacaccactt tgcttaccac atcatggatt accgtctcac      420



tcttctgttt tgtcaccatc gtttcagctc caaagtcaca aaaactatga aggaacttgt      480



gagattcctg aatctaaata tagcccatta ggtggtccca aaccctttga gtgcccaagt      540



attcaaatta catctatctc tcctaactgt catcaagaat tagatgcaca tgaagatgac      600



ctacagataa atgacccaga acgggaattt ttggaaaggc cttctagaga tcatctctat      660



cttcctcttg agccatccta ccgggagtct tctcttagtc ctagtcctgc cagcagcatc      720



tcttctagga gttggttctc tgatgcatct tcttgtgaat cgctttcaca tatttatgat      780



gatgtggact cagagttgaa tgaagctgca gcccgattta cccttggatc ccctctgact      840



tctcctggtg gctctccagg gggctgccct ggagaagaaa cttggcatca acagtatgga      900



cttggacact cattatcacc caggcaatct ccttgccact ctcctagatc cagtgtcact      960



gatgagaatt ggctgagccc caggccagcc tcaggaccct catcaaggcc cacatccccc     1020



tgtgggaaac ggaggcactc cagtgctgaa gtttgttatg ctgggtccct ttcaccccat     1080



cactcacctg ttccttcacc tggtcactcc cccaggggaa gtgtgacaga agatacgtgg     1140



ctcaatgctt ctgtccatgg tgggtcaggc cttggccctg cagtttttcc atttcagtac     1200



tgtgtagaga ctgacatccc tctcaaaaca aggaaaactt ctgaagatca agctgccata     1260



ctaccaggaa aattagagct gtgttcagat gaccaaggga gtttatcacc agcccgggag     1320



acttcaatag atgatggcct tggatctcag tatcctttaa agaaagattc atgtggtgat     1380



cagtttcttt cagttccttc accctttacc tggagcaaac caaagcctgg ccacacccct     1440



atatttcgca catcttcatt acctccacta gactggcctt taccagctca ttttggacaa     1500



tgtgaactga aaatagaagt gcaacctaaa actcatcatc gagcccatta tgaaactgaa     1560



ggtagccgag gggcagtaaa agcatctact gggggacatc ctgttgtgaa gctcctgggc     1620



tataacgaaa agccaataaa tctacaaatg tttattggga cagcagatga tcgatattta     1680



cgacctcatg cattttacca ggtgcatcga atcactggga agacagtcgc tactgcaagc     1740



caagagataa taattgccag tacaaaagtt ctggaaattc cacttcttcc tgaaaataat     1800



atgtcagcca gtattgattg tgcaggtatt ttgaaactcc gcaattcaga tatagaactt     1860



cgaaaaggag aaactgatat tggcagaaag aatactagag tacgacttgt gtttcgtgta     1920



cacatcccac agcccagtgg aaaagtcctt tctctgcaga tagcctctat acccgttgag     1980



tgctcccagc ggtctgctca agaacttcct catattgaga agtacagtat caacagttgt     2040



tctgtaaatg gaggtcatga aatggttgtg actggatcta attttcttcc agaatccaaa     2100



atcatttttc ttgaaaaagg acaagatgga cgacctcagt gggaggtaga agggaagata     2160



atcagggaaa aatgtcaagg ggctcacatt gtccttgaag ttcctccata tcataaccca     2220



gcagttacag ctgcagtgca ggtgcacttt tatctttgca atggcaagag gaaaaaaagc     2280



cagtctcaac gttttactta tacaccagtt ttgatgaagc aagaacacag agaagagatt     2340



gatttgtctt cagttccatc tttgcctgtg cctcatcctg ctcagaccca gaggccttcc     2400



tctgattcag ggtgttcaca tgacagtgta ctgtcaggac agagaagttt gatttgctcc     2460



atcccacaaa catatgcatc catggtgacc tcatcccatc tgccacagtt gcagtgtaga     2520



gatgagagtg ttagtaaaga acagcatatg attccttctc caattgtaca ccagcctttt     2580



caagtcacac caacacctcc tgtggggtct tcctatcagc ctatgcaaac taatgttgtg     2640



tacaatggac caacttgtct tcctattaat gctgcctcta gtcaagaatt tgattcagtt     2700



ttgtttcagc aggatgcaac tctttctggt ttagtgaatc ttggctgtca accactgtca     2760



tccataccat ttcattcttc aaattcaggc tcaacaggac atctcttagc ccatacacct     2820



cattctgtgc ataccctgcc tcatctgcaa tcaatgggat atcattgttc aaatacagga     2880



caaagatctc tttcttctcc agtggctgac cagattacag gtcagccttc gtctcagtta     2940



caacctatta catatggtcc ttcacattca gggtctgcta caacagcttc cccagcagct     3000



tctcatccct tggctagttc accgctttct gggccaccat ctcctcagct tcagcctatg     3060



ccttaccaat ctcctagctc aggaactgcc tcatcaccgt ctccagccac cagaatgcat     3120



tctggacagc actcaactca agcacaaagt acgggccagg ggggtctttc tgcaccttca     3180



tccttaatat gtcacagttt gtgtgatcca gcgtcatttc cacctgatgg ggcaactgtg     3240



agcattaaac ctgaaccaga agatcgagag cctaactttg caaccattgg tctgcaggac     3300



atcactttag atgatgattt gtttaccagt aataattttg acttgcttca gttgagacct     3360



acgttttggc cagtcccagc aggaagatat ctgaggaatc tagagtgaac gagataattg     3420



ggagagacat gtcccagatt tctgtttccc aaggagcagg ggtgagcagg caggctcccc     3480



tcccgagtcc tgagtccctg gatttaggaa gatctgatgg gctctaacag tgcttactgc     3540



agccttgtgt ccaccaccaa cttctcagca tgtttctctc cttggacctt gggtttccaa     3600



ctctgcagcc ttcaggtctg gggccaggag tgggacccac catttgtggg gaaagtagca     3660



ttcctccacc tcaggccttg ggtagatttg gcaaaagaac aggagcagca taggctgttt     3720



gagctttggg gaaatgaact ttgcttttta tatttaacta ggatactttt atatgatggg     3780



tgctttgagt gtgaatgcag caggctctct tgtttccgag gtgctgcttt tgcaggtgac     3840



ctggttactt agctaggatt ggtgatttgt actgctttat ggtcatttga agggcccttt     3900



agtttttatg ataattttta aaataggaac ttttgataag accttctaga agcaaaaaaa     3960



aaaaaaaaaa aaaaaaaaag aaaaaaaaag                                      3990





<210>  98

<211>  1065

<212>  PRT

<213>  Homo sapiens



<400>  98



Met Thr Thr Ala Asn Cys Gly Ala His Asp Glu Leu Asp Phe Lys Leu 

1               5                   10                  15      





Val Phe Gly Glu Asp Gly Ala Pro Ala Pro Pro Pro Pro Gly Ser Arg 

            20                  25                  30          





Pro Ala Asp Leu Glu Pro Asp Asp Cys Ala Ser Ile Tyr Ile Phe Asn 

        35                  40                  45              





Val Asp Pro Pro Pro Ser Thr Leu Thr Thr Pro Leu Cys Leu Pro His 

    50                  55                  60                  





His Gly Leu Pro Ser His Ser Ser Val Leu Ser Pro Ser Phe Gln Leu 

65                  70                  75                  80  





Gln Ser His Lys Asn Tyr Glu Gly Thr Cys Glu Ile Pro Glu Ser Lys 

                85                  90                  95      





Tyr Ser Pro Leu Gly Gly Pro Lys Pro Phe Glu Cys Pro Ser Ile Gln 

            100                 105                 110         





Ile Thr Ser Ile Ser Pro Asn Cys His Gln Glu Leu Asp Ala His Glu 

        115                 120                 125             





Asp Asp Leu Gln Ile Asn Asp Pro Glu Arg Glu Phe Leu Glu Arg Pro 

    130                 135                 140                 





Ser Arg Asp His Leu Tyr Leu Pro Leu Glu Pro Ser Tyr Arg Glu Ser 

145                 150                 155                 160 





Ser Leu Ser Pro Ser Pro Ala Ser Ser Ile Ser Ser Arg Ser Trp Phe 

                165                 170                 175     





Ser Asp Ala Ser Ser Cys Glu Ser Leu Ser His Ile Tyr Asp Asp Val 

            180                 185                 190         





Asp Ser Glu Leu Asn Glu Ala Ala Ala Arg Phe Thr Leu Gly Ser Pro 

        195                 200                 205             





Leu Thr Ser Pro Gly Gly Ser Pro Gly Gly Cys Pro Gly Glu Glu Thr 

    210                 215                 220                 





Trp His Gln Gln Tyr Gly Leu Gly His Ser Leu Ser Pro Arg Gln Ser 

225                 230                 235                 240 





Pro Cys His Ser Pro Arg Ser Ser Val Thr Asp Glu Asn Trp Leu Ser 

                245                 250                 255     





Pro Arg Pro Ala Ser Gly Pro Ser Ser Arg Pro Thr Ser Pro Cys Gly 

            260                 265                 270         





Lys Arg Arg His Ser Ser Ala Glu Val Cys Tyr Ala Gly Ser Leu Ser 

        275                 280                 285             





Pro His His Ser Pro Val Pro Ser Pro Gly His Ser Pro Arg Gly Ser 

    290                 295                 300                 





Val Thr Glu Asp Thr Trp Leu Asn Ala Ser Val His Gly Gly Ser Gly 

305                 310                 315                 320 





Leu Gly Pro Ala Val Phe Pro Phe Gln Tyr Cys Val Glu Thr Asp Ile 

                325                 330                 335     





Pro Leu Lys Thr Arg Lys Thr Ser Glu Asp Gln Ala Ala Ile Leu Pro 

            340                 345                 350         





Gly Lys Leu Glu Leu Cys Ser Asp Asp Gln Gly Ser Leu Ser Pro Ala 

        355                 360                 365             





Arg Glu Thr Ser Ile Asp Asp Gly Leu Gly Ser Gln Tyr Pro Leu Lys 

    370                 375                 380                 





Lys Asp Ser Cys Gly Asp Gln Phe Leu Ser Val Pro Ser Pro Phe Thr 

385                 390                 395                 400 





Trp Ser Lys Pro Lys Pro Gly His Thr Pro Ile Phe Arg Thr Ser Ser 

                405                 410                 415     





Leu Pro Pro Leu Asp Trp Pro Leu Pro Ala His Phe Gly Gln Cys Glu 

            420                 425                 430         





Leu Lys Ile Glu Val Gln Pro Lys Thr His His Arg Ala His Tyr Glu 

        435                 440                 445             





Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ser Thr Gly Gly His Pro 

    450                 455                 460                 





Val Val Lys Leu Leu Gly Tyr Asn Glu Lys Pro Ile Asn Leu Gln Met 

465                 470                 475                 480 





Phe Ile Gly Thr Ala Asp Asp Arg Tyr Leu Arg Pro His Ala Phe Tyr 

                485                 490                 495     





Gln Val His Arg Ile Thr Gly Lys Thr Val Ala Thr Ala Ser Gln Glu 

            500                 505                 510         





Ile Ile Ile Ala Ser Thr Lys Val Leu Glu Ile Pro Leu Leu Pro Glu 

        515                 520                 525             





Asn Asn Met Ser Ala Ser Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg 

    530                 535                 540                 





Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys 

545                 550                 555                 560 





Asn Thr Arg Val Arg Leu Val Phe Arg Val His Ile Pro Gln Pro Ser 

                565                 570                 575     





Gly Lys Val Leu Ser Leu Gln Ile Ala Ser Ile Pro Val Glu Cys Ser 

            580                 585                 590         





Gln Arg Ser Ala Gln Glu Leu Pro His Ile Glu Lys Tyr Ser Ile Asn 

        595                 600                 605             





Ser Cys Ser Val Asn Gly Gly His Glu Met Val Val Thr Gly Ser Asn 

    610                 615                 620                 





Phe Leu Pro Glu Ser Lys Ile Ile Phe Leu Glu Lys Gly Gln Asp Gly 

625                 630                 635                 640 





Arg Pro Gln Trp Glu Val Glu Gly Lys Ile Ile Arg Glu Lys Cys Gln 

                645                 650                 655     





Gly Ala His Ile Val Leu Glu Val Pro Pro Tyr His Asn Pro Ala Val 

            660                 665                 670         





Thr Ala Ala Val Gln Val His Phe Tyr Leu Cys Asn Gly Lys Arg Lys 

        675                 680                 685             





Lys Ser Gln Ser Gln Arg Phe Thr Tyr Thr Pro Val Leu Met Lys Gln 

    690                 695                 700                 





Glu His Arg Glu Glu Ile Asp Leu Ser Ser Val Pro Ser Leu Pro Val 

705                 710                 715                 720 





Pro His Pro Ala Gln Thr Gln Arg Pro Ser Ser Asp Ser Gly Cys Ser 

                725                 730                 735     





His Asp Ser Val Leu Ser Gly Gln Arg Ser Leu Ile Cys Ser Ile Pro 

            740                 745                 750         





Gln Thr Tyr Ala Ser Met Val Thr Ser Ser His Leu Pro Gln Leu Gln 

        755                 760                 765             





Cys Arg Asp Glu Ser Val Ser Lys Glu Gln His Met Ile Pro Ser Pro 

    770                 775                 780                 





Ile Val His Gln Pro Phe Gln Val Thr Pro Thr Pro Pro Val Gly Ser 

785                 790                 795                 800 





Ser Tyr Gln Pro Met Gln Thr Asn Val Val Tyr Asn Gly Pro Thr Cys 

                805                 810                 815     





Leu Pro Ile Asn Ala Ala Ser Ser Gln Glu Phe Asp Ser Val Leu Phe 

            820                 825                 830         





Gln Gln Asp Ala Thr Leu Ser Gly Leu Val Asn Leu Gly Cys Gln Pro 

        835                 840                 845             





Leu Ser Ser Ile Pro Phe His Ser Ser Asn Ser Gly Ser Thr Gly His 

    850                 855                 860                 





Leu Leu Ala His Thr Pro His Ser Val His Thr Leu Pro His Leu Gln 

865                 870                 875                 880 





Ser Met Gly Tyr His Cys Ser Asn Thr Gly Gln Arg Ser Leu Ser Ser 

                885                 890                 895     





Pro Val Ala Asp Gln Ile Thr Gly Gln Pro Ser Ser Gln Leu Gln Pro 

            900                 905                 910         





Ile Thr Tyr Gly Pro Ser His Ser Gly Ser Ala Thr Thr Ala Ser Pro 

        915                 920                 925             





Ala Ala Ser His Pro Leu Ala Ser Ser Pro Leu Ser Gly Pro Pro Ser 

    930                 935                 940                 





Pro Gln Leu Gln Pro Met Pro Tyr Gln Ser Pro Ser Ser Gly Thr Ala 

945                 950                 955                 960 





Ser Ser Pro Ser Pro Ala Thr Arg Met His Ser Gly Gln His Ser Thr 

                965                 970                 975     





Gln Ala Gln Ser Thr Gly Gln Gly Gly Leu Ser Ala Pro Ser Ser Leu 

            980                 985                 990         





Ile Cys His Ser Leu Cys Asp Pro  Ala Ser Phe Pro Pro  Asp Gly Ala 

        995                 1000                 1005             





Thr Val  Ser Ile Lys Pro Glu  Pro Glu Asp Arg Glu  Pro Asn Phe 

    1010                 1015                 1020             





Ala Thr  Ile Gly Leu Gln Asp  Ile Thr Leu Asp Asp  Asp Leu Phe 

    1025                 1030                 1035             





Thr Ser  Asn Asn Phe Asp Leu  Leu Gln Leu Arg Pro  Thr Phe Trp 

    1040                 1045                 1050             





Pro Val  Pro Ala Gly Arg Tyr  Leu Arg Asn Leu Glu  

    1055                 1060                 1065 





<210>  99

<211>  3769

<212>  DNA

<213>  Homo sapiens



<400>  99

cggctgcggt tcctggtgct gctcggcgcg cggccagctt tcggaacgga acgctcggcg       60



tcgcgggccc cgcccggaaa gtttgccgtg gagtcgcgac ctcttggccc gcgcggcccg      120



gcatgaagcg gcgttgagga gctgctgccg ccgcttgccg ctgccgccgc cgccgcctga      180



ggaggagctg cagcaccctg ggccacgccg atgactactg caaactgtgg cgcccacgac      240



gagctcgact tcaaactcgt ctttggcgag gacggggcgc cggcgccgcc gcccccgggc      300



tcgcggcctg cagatcttga gccagatgat tgtgcatcca tttacatctt taatgtagat      360



ccacctccat ctactttaac cacaccactt tgcttaccac atcatggatt accgtctcac      420



tcttctgttt tgtcaccatc gtttcagctc caaagtcaca aaaactatga aggaacttgt      480



gagattcctg aatctaaata tagcccatta ggtggtccca aaccctttga gtgcccaagt      540



attcaaatta catctatctc tcctaactgt catcaagaat tagatgcaca tgaagatgac      600



ctacagataa atgacccaga acgggaattt ttggaaaggc cttctagaga tcatctctat      660



cttcctcttg agccatccta ccgggagtct tctcttagtc ctagtcctgc cagcagcatc      720



tcttctagga gttggttctc tgatgcatct tcttgtgaat cgctttcaca tatttatgat      780



gatgtggact cagagttgaa tgaagctgca gcccgattta cccttggatc ccctctgact      840



tctcctggtg gctctccagg gggctgccct ggagaagaaa cttggcatca acagtatgga      900



cttggacact cattatcacc caggcaatct ccttgccact ctcctagatc cagtgtcact      960



gatgagaatt ggctgagccc caggccagcc tcaggaccct catcaaggcc cacatccccc     1020



tgtgggaaac ggaggcactc cagtgctgaa gtttgttatg ctgggtccct ttcaccccat     1080



cactcacctg ttccttcacc tggtcactcc cccaggggaa gtgtgacaga agatacgtgg     1140



ctcaatgctt ctgtccatgg tgggtcaggc cttggccctg cagtttttcc atttcagtac     1200



tgtgtagaga ctgacatccc tctcaaaaca aggaaaactt ctgaagatca agctgccata     1260



ctaccaggaa aattagagct gtgttcagat gaccaaggga gtttatcacc agcccgggag     1320



acttcaatag atgatggcct tggatctcag tatcctttaa agaaagattc atgtggtgat     1380



cagtttcttt cagttccttc accctttacc tggagcaaac caaagcctgg ccacacccct     1440



atatttcgca catcttcatt acctccacta gactggcctt taccagctca ttttggacaa     1500



tgtgaactga aaatagaagt gcaacctaaa actcatcatc gagcccatta tgaaactgaa     1560



ggtagccgag gggcagtaaa agcatctact gggggacatc ctgttgtgaa gctcctgggc     1620



tataacgaaa agccaataaa tctacaaatg tttattggga cagcagatga tcgatattta     1680



cgacctcatg cattttacca ggtgcatcga atcactggga agacagtcgc tactgcaagc     1740



caagagataa taattgccag tacaaaagtt ctggaaattc cacttcttcc tgaaaataat     1800



atgtcagcca gtattgattg tgcaggtatt ttgaaactcc gcaattcaga tatagaactt     1860



cgaaaaggag aaactgatat tggcagaaag aatactagag tacgacttgt gtttcgtgta     1920



cacatcccac agcccagtgg aaaagtcctt tctctgcaga tagcctctat acccgttgag     1980



tgctcccagc ggtctgctca agaacttcct catattgaga agtacagtat caacagttgt     2040



tctgtaaatg gaggtcatga aatggttgtg actggatcta attttcttcc agaatccaaa     2100



atcatttttc ttgaaaaagg acaagatgga cgacctcagt gggaggtaga agggaagata     2160



atcagggaaa aatgtcaagg ggctcacatt gtccttgaag ttcctccata tcataaccca     2220



gcagttacag ctgcagtgca ggtgcacttt tatctttgca atggcaagag gaaaaaaagc     2280



cagtctcaac gttttactta tacaccagtt ttgatgaagc aagaacacag agaagagatt     2340



gatttgtctt cagttccatc tttgcctgtg cctcatcctg ctcagaccca gaggccttcc     2400



tctgattcag ggtgttcaca tgacagtgta ctgtcaggac agagaagttt gatttgctcc     2460



atcccacaaa catatgcatc catggtgacc tcatcccatc tgccacagtt gcagtgtaga     2520



gatgagagtg ttagtaaaga acagcatatg attccttctc caattgtaca ccagcctttt     2580



caagtcacac caacacctcc tgtggggtct tcctatcagc ctatgcaaac taatgttgtg     2640



tacaatggac caacttgtct tcctattaat gctgcctcta gtcaagaatt tgattcagtt     2700



ttgtttcagc aggatgcaac tctttctggt ttagtgaatc ttggctgtca accactgtca     2760



tccataccat ttcattcttc aaattcaggc tcaacaggac atctcttagc ccatacacct     2820



cattctgtgc ataccctgcc tcatctgcaa tcaatgggat atcattgttc aaatacagga     2880



caaagatctc tttcttctcc agtggctgac cagattacag gtcagccttc gtctcagtta     2940



caacctatta catatggtcc ttcacattca gggtctgcta caacagcttc cccagcagct     3000



tctcatccct tggctagttc accgctttct gggccaccat ctcctcagct tcagcctatg     3060



ccttaccaat ctcctagctc aggaactgcc tcatcaccgt ctccagccac cagaatgcat     3120



tctggacagc actcaactca agcacaaagt acgggccagg ggggtctttc tgcaccttca     3180



tccttaatat gtcacagttt gtgtgatcca gcgtcatttc cacctgatgg ggcaactgtg     3240



agcattaaac ctgaaccaga agatcgagag cctaactttg caaccattgg tctgcaggac     3300



atcactttag atgatggtaa gttcatctct gatatgttct tgaagtagtg aagattcagg     3360



gactttattc tcccaagtgt catgaaaaag tttctatgga ttgcttattg gcatatggtt     3420



gggcttttaa ataagttgtt attagaaata tatgttaata tataactttg ccaggtacca     3480



cggctcacgc ctgtatccca gcactttgga aggctgaggc gggtggatca caaggtcagg     3540



agttcaagac cagcctggcc aacatggtgt aacgctgtct ctactaaaaa tacaaaaaat     3600



tagccaggca tggtggtgtg tgactataat cccagctact cgggaggctg agacaggaga     3660



atcacttgaa cccgggaggt ggcagttgca gggagctaag atcgcgccat tgcactccag     3720



cctgggcggc agagcaagac tccgtctcgg gaaaaaaaaa aaaaaaaaa                 3769





<210>  100

<211>  1045

<212>  PRT

<213>  Homo sapiens



<400>  100



Met Thr Thr Ala Asn Cys Gly Ala His Asp Glu Leu Asp Phe Lys Leu 

1               5                   10                  15      





Val Phe Gly Glu Asp Gly Ala Pro Ala Pro Pro Pro Pro Gly Ser Arg 

            20                  25                  30          





Pro Ala Asp Leu Glu Pro Asp Asp Cys Ala Ser Ile Tyr Ile Phe Asn 

        35                  40                  45              





Val Asp Pro Pro Pro Ser Thr Leu Thr Thr Pro Leu Cys Leu Pro His 

    50                  55                  60                  





His Gly Leu Pro Ser His Ser Ser Val Leu Ser Pro Ser Phe Gln Leu 

65                  70                  75                  80  





Gln Ser His Lys Asn Tyr Glu Gly Thr Cys Glu Ile Pro Glu Ser Lys 

                85                  90                  95      





Tyr Ser Pro Leu Gly Gly Pro Lys Pro Phe Glu Cys Pro Ser Ile Gln 

            100                 105                 110         





Ile Thr Ser Ile Ser Pro Asn Cys His Gln Glu Leu Asp Ala His Glu 

        115                 120                 125             





Asp Asp Leu Gln Ile Asn Asp Pro Glu Arg Glu Phe Leu Glu Arg Pro 

    130                 135                 140                 





Ser Arg Asp His Leu Tyr Leu Pro Leu Glu Pro Ser Tyr Arg Glu Ser 

145                 150                 155                 160 





Ser Leu Ser Pro Ser Pro Ala Ser Ser Ile Ser Ser Arg Ser Trp Phe 

                165                 170                 175     





Ser Asp Ala Ser Ser Cys Glu Ser Leu Ser His Ile Tyr Asp Asp Val 

            180                 185                 190         





Asp Ser Glu Leu Asn Glu Ala Ala Ala Arg Phe Thr Leu Gly Ser Pro 

        195                 200                 205             





Leu Thr Ser Pro Gly Gly Ser Pro Gly Gly Cys Pro Gly Glu Glu Thr 

    210                 215                 220                 





Trp His Gln Gln Tyr Gly Leu Gly His Ser Leu Ser Pro Arg Gln Ser 

225                 230                 235                 240 





Pro Cys His Ser Pro Arg Ser Ser Val Thr Asp Glu Asn Trp Leu Ser 

                245                 250                 255     





Pro Arg Pro Ala Ser Gly Pro Ser Ser Arg Pro Thr Ser Pro Cys Gly 

            260                 265                 270         





Lys Arg Arg His Ser Ser Ala Glu Val Cys Tyr Ala Gly Ser Leu Ser 

        275                 280                 285             





Pro His His Ser Pro Val Pro Ser Pro Gly His Ser Pro Arg Gly Ser 

    290                 295                 300                 





Val Thr Glu Asp Thr Trp Leu Asn Ala Ser Val His Gly Gly Ser Gly 

305                 310                 315                 320 





Leu Gly Pro Ala Val Phe Pro Phe Gln Tyr Cys Val Glu Thr Asp Ile 

                325                 330                 335     





Pro Leu Lys Thr Arg Lys Thr Ser Glu Asp Gln Ala Ala Ile Leu Pro 

            340                 345                 350         





Gly Lys Leu Glu Leu Cys Ser Asp Asp Gln Gly Ser Leu Ser Pro Ala 

        355                 360                 365             





Arg Glu Thr Ser Ile Asp Asp Gly Leu Gly Ser Gln Tyr Pro Leu Lys 

    370                 375                 380                 





Lys Asp Ser Cys Gly Asp Gln Phe Leu Ser Val Pro Ser Pro Phe Thr 

385                 390                 395                 400 





Trp Ser Lys Pro Lys Pro Gly His Thr Pro Ile Phe Arg Thr Ser Ser 

                405                 410                 415     





Leu Pro Pro Leu Asp Trp Pro Leu Pro Ala His Phe Gly Gln Cys Glu 

            420                 425                 430         





Leu Lys Ile Glu Val Gln Pro Lys Thr His His Arg Ala His Tyr Glu 

        435                 440                 445             





Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ser Thr Gly Gly His Pro 

    450                 455                 460                 





Val Val Lys Leu Leu Gly Tyr Asn Glu Lys Pro Ile Asn Leu Gln Met 

465                 470                 475                 480 





Phe Ile Gly Thr Ala Asp Asp Arg Tyr Leu Arg Pro His Ala Phe Tyr 

                485                 490                 495     





Gln Val His Arg Ile Thr Gly Lys Thr Val Ala Thr Ala Ser Gln Glu 

            500                 505                 510         





Ile Ile Ile Ala Ser Thr Lys Val Leu Glu Ile Pro Leu Leu Pro Glu 

        515                 520                 525             





Asn Asn Met Ser Ala Ser Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg 

    530                 535                 540                 





Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys 

545                 550                 555                 560 





Asn Thr Arg Val Arg Leu Val Phe Arg Val His Ile Pro Gln Pro Ser 

                565                 570                 575     





Gly Lys Val Leu Ser Leu Gln Ile Ala Ser Ile Pro Val Glu Cys Ser 

            580                 585                 590         





Gln Arg Ser Ala Gln Glu Leu Pro His Ile Glu Lys Tyr Ser Ile Asn 

        595                 600                 605             





Ser Cys Ser Val Asn Gly Gly His Glu Met Val Val Thr Gly Ser Asn 

    610                 615                 620                 





Phe Leu Pro Glu Ser Lys Ile Ile Phe Leu Glu Lys Gly Gln Asp Gly 

625                 630                 635                 640 





Arg Pro Gln Trp Glu Val Glu Gly Lys Ile Ile Arg Glu Lys Cys Gln 

                645                 650                 655     





Gly Ala His Ile Val Leu Glu Val Pro Pro Tyr His Asn Pro Ala Val 

            660                 665                 670         





Thr Ala Ala Val Gln Val His Phe Tyr Leu Cys Asn Gly Lys Arg Lys 

        675                 680                 685             





Lys Ser Gln Ser Gln Arg Phe Thr Tyr Thr Pro Val Leu Met Lys Gln 

    690                 695                 700                 





Glu His Arg Glu Glu Ile Asp Leu Ser Ser Val Pro Ser Leu Pro Val 

705                 710                 715                 720 





Pro His Pro Ala Gln Thr Gln Arg Pro Ser Ser Asp Ser Gly Cys Ser 

                725                 730                 735     





His Asp Ser Val Leu Ser Gly Gln Arg Ser Leu Ile Cys Ser Ile Pro 

            740                 745                 750         





Gln Thr Tyr Ala Ser Met Val Thr Ser Ser His Leu Pro Gln Leu Gln 

        755                 760                 765             





Cys Arg Asp Glu Ser Val Ser Lys Glu Gln His Met Ile Pro Ser Pro 

    770                 775                 780                 





Ile Val His Gln Pro Phe Gln Val Thr Pro Thr Pro Pro Val Gly Ser 

785                 790                 795                 800 





Ser Tyr Gln Pro Met Gln Thr Asn Val Val Tyr Asn Gly Pro Thr Cys 

                805                 810                 815     





Leu Pro Ile Asn Ala Ala Ser Ser Gln Glu Phe Asp Ser Val Leu Phe 

            820                 825                 830         





Gln Gln Asp Ala Thr Leu Ser Gly Leu Val Asn Leu Gly Cys Gln Pro 

        835                 840                 845             





Leu Ser Ser Ile Pro Phe His Ser Ser Asn Ser Gly Ser Thr Gly His 

    850                 855                 860                 





Leu Leu Ala His Thr Pro His Ser Val His Thr Leu Pro His Leu Gln 

865                 870                 875                 880 





Ser Met Gly Tyr His Cys Ser Asn Thr Gly Gln Arg Ser Leu Ser Ser 

                885                 890                 895     





Pro Val Ala Asp Gln Ile Thr Gly Gln Pro Ser Ser Gln Leu Gln Pro 

            900                 905                 910         





Ile Thr Tyr Gly Pro Ser His Ser Gly Ser Ala Thr Thr Ala Ser Pro 

        915                 920                 925             





Ala Ala Ser His Pro Leu Ala Ser Ser Pro Leu Ser Gly Pro Pro Ser 

    930                 935                 940                 





Pro Gln Leu Gln Pro Met Pro Tyr Gln Ser Pro Ser Ser Gly Thr Ala 

945                 950                 955                 960 





Ser Ser Pro Ser Pro Ala Thr Arg Met His Ser Gly Gln His Ser Thr 

                965                 970                 975     





Gln Ala Gln Ser Thr Gly Gln Gly Gly Leu Ser Ala Pro Ser Ser Leu 

            980                 985                 990         





Ile Cys His Ser Leu Cys Asp Pro  Ala Ser Phe Pro Pro  Asp Gly Ala 

        995                 1000                 1005             





Thr Val  Ser Ile Lys Pro Glu  Pro Glu Asp Arg Glu  Pro Asn Phe 

    1010                 1015                 1020             





Ala Thr  Ile Gly Leu Gln Asp  Ile Thr Leu Asp Asp  Gly Lys Phe 

    1025                 1030                 1035             





Ile Ser  Asp Met Phe Leu Lys  

    1040                 1045 





<210>  101

<211>  3901

<212>  DNA

<213>  Homo sapiens



<400>  101

cggctgcggt tcctggtgct gctcggcgcg cggccagctt tcggaacgga acgctcggcg       60



tcgcgggccc cgcccggaaa gtttgccgtg gagtcgcgac ctcttggccc gcgcggcccg      120



gcatgaagcg gcgttgagga gctgctgccg ccgcttgccg ctgccgccgc cgccgcctga      180



ggaggagctg cagcaccctg ggccacgccg atgactactg caaactgtgg cgcccacgac      240



gagctcgact tcaaactcgt ctttggcgag gacggggcgc cggcgccgcc gcccccgggc      300



tcgcggcctg cagatcttga gccagatgat tgtgcatcca tttacatctt taatgtagat      360



ccacctccat ctactttaac cacaccactt tgcttaccac atcatggatt accgtctcac      420



tcttctgttt tgtcaccatc gtttcagctc caaagtcaca aaaactatga aggaacttgt      480



gagattcctg aatctaaata tagcccatta ggtggtccca aaccctttga gtgcccaagt      540



attcaaatta catctatctc tcctaactgt catcaagaat tagatgcaca tgaagatgac      600



ctacagataa atgacccaga acgggaattt ttggaaaggc cttctagaga tcatctctat      660



cttcctcttg agccatccta ccgggagtct tctcttagtc ctagtcctgc cagcagcatc      720



tcttctagga gttggttctc tgatgcatct tcttgtgaat cgctttcaca tatttatgat      780



gatgtggact cagagttgaa tgaagctgca gcccgattta cccttggatc ccctctgact      840



tctcctggtg gctctccagg gggctgccct ggagaagaaa cttggcatca acagtatgga      900



cttggacact cattatcacc caggcaatct ccttgccact ctcctagatc cagtgtcact      960



gatgagaatt ggctgagccc caggccagcc tcaggaccct catcaaggcc cacatccccc     1020



tgtgggaaac ggaggcactc cagtgctgaa gtttgttatg ctgggtccct ttcaccccat     1080



cactcacctg ttccttcacc tggtcactcc cccaggggaa gtgtgacaga agatacgtgg     1140



ctcaatgctt ctgtccatgg tgggtcaggc cttggccctg cagtttttcc atttcagtac     1200



tgtgtagaga ctgacatccc tctcaaaaca aggaaaactt ctgaagatca agctgccata     1260



ctaccaggaa aattagagct gtgttcagat gaccaaggga gtttatcacc agcccgggag     1320



acttcaatag atgatggcct tggatctcag tatcctttaa agaaagattc atgtggtgat     1380



cagtttcttt cagttccttc accctttacc tggagcaaac caaagcctgg ccacacccct     1440



atatttcgca catcttcatt acctccacta gactggcctt taccagctca ttttggacaa     1500



tgtgaactga aaatagaagt gcaacctaaa actcatcatc gagcccatta tgaaactgaa     1560



ggtagccgag gggcagtaaa agcatctact gggggacatc ctgttgtgaa gctcctgggc     1620



tataacgaaa agccaataaa tctacaaatg tttattggga cagcagatga tcgatattta     1680



cgacctcatg cattttacca ggtgcatcga atcactggga agacagtcgc tactgcaagc     1740



caagagataa taattgccag tacaaaagtt ctggaaattc cacttcttcc tgaaaataat     1800



atgtcagcca gtattgattg tgcaggtatt ttgaaactcc gcaattcaga tatagaactt     1860



cgaaaaggag aaactgatat tggcagaaag aatactagag tacgacttgt gtttcgtgta     1920



cacatcccac agcccagtgg aaaagtcctt tctctgcaga tagcctctat acccgttgag     1980



tgctcccagc ggtctgctca agaacttcct catattgaga agtacagtat caacagttgt     2040



tctgtaaatg gaggtcatga aatggttgtg actggatcta attttcttcc agaatccaaa     2100



atcatttttc ttgaaaaagg acaagatgga cgacctcagt gggaggtaga agggaagata     2160



atcagggaaa aatgtcaagg ggctcacatt gtccttgaag ttcctccata tcataaccca     2220



gcagttacag ctgcagtgca ggtgcacttt tatctttgca atggcaagag gaaaaaaagc     2280



cagtctcaac gttttactta tacaccagtt ttgatgaagc aagaacacag agaagagatt     2340



gatttgtctt cagttccatc tttgcctgtg cctcatcctg ctcagaccca gaggccttcc     2400



tctgattcag ggtgttcaca tgacagtgta ctgtcaggac agagaagttt gatttgctcc     2460



atcccacaaa catatgcatc catggtgacc tcatcccatc tgccacagtt gcagtgtaga     2520



gatgagagtg ttagtaaaga acagcatatg attccttctc caattgtaca ccagcctttt     2580



caagtcacac caacacctcc tgtggggtct tcctatcagc ctatgcaaac taatgttgtg     2640



tacaatggac caacttgtct tcctattaat gctgcctcta gtcaagaatt tgattcagtt     2700



ttgtttcagc aggatgcaac tctttctggt ttagtgaatc ttggctgtca accactgtca     2760



tccataccat ttcattcttc aaattcaggc tcaacaggac atctcttagc ccatacacct     2820



cattctgtgc ataccctgcc tcatctgcaa tcaatgggat atcattgttc aaatacagga     2880



caaagatctc tttcttctcc agtggctgac cagattacag gtcagccttc gtctcagtta     2940



caacctatta catatggtcc ttcacattca gggtctgcta caacagcttc cccagcagct     3000



tctcatccct tggctagttc accgctttct gggccaccat ctcctcagct tcagcctatg     3060



ccttaccaat ctcctagctc aggaactgcc tcatcaccgt ctccagccac cagaatgcat     3120



tctggacagc actcaactca agcacaaagt acgggccagg ggggtctttc tgcaccttca     3180



tccttaatat gtcacagttt gtgtgatcca gcgtcatttc cacctgatgg ggcaactgtg     3240



agcattaaac ctgaaccaga agatcgagag cctaactttg caaccattgg tctgcaggac     3300



atcactttag atgatgtgaa cgagataatt gggagagaca tgtcccagat ttctgtttcc     3360



caaggagcag gggtgagcag gcaggctccc ctcccgagtc ctgagtccct ggatttagga     3420



agatctgatg ggctctaaca gtgcttactg cagccttgtg tccaccacca acttctcagc     3480



atgtttctct ccttggacct tgggtttcca actctgcagc cttcaggtct ggggccagga     3540



gtgggaccca ccatttgtgg ggaaagtagc attcctccac ctcaggcctt gggtagattt     3600



ggcaaaagaa caggagcagc ataggctgtt tgagctttgg ggaaatgaac tttgcttttt     3660



atatttaact aggatacttt tatatgatgg gtgctttgag tgtgaatgca gcaggctctc     3720



ttgtttccga ggtgctgctt ttgcaggtga cctggttact tagctaggat tggtgatttg     3780



tactgcttta tggtcatttg aagggccctt tagtttttat gataattttt aaaataggaa     3840



cttttgataa gaccttctag aagcaaaaaa aaaaaaaaaa aaaaaaaaaa gaaaaaaaaa     3900



g                                                                     3901





<210>  102

<211>  1075

<212>  PRT

<213>  Homo sapiens



<400>  102



Met Thr Thr Ala Asn Cys Gly Ala His Asp Glu Leu Asp Phe Lys Leu 

1               5                   10                  15      





Val Phe Gly Glu Asp Gly Ala Pro Ala Pro Pro Pro Pro Gly Ser Arg 

            20                  25                  30          





Pro Ala Asp Leu Glu Pro Asp Asp Cys Ala Ser Ile Tyr Ile Phe Asn 

        35                  40                  45              





Val Asp Pro Pro Pro Ser Thr Leu Thr Thr Pro Leu Cys Leu Pro His 

    50                  55                  60                  





His Gly Leu Pro Ser His Ser Ser Val Leu Ser Pro Ser Phe Gln Leu 

65                  70                  75                  80  





Gln Ser His Lys Asn Tyr Glu Gly Thr Cys Glu Ile Pro Glu Ser Lys 

                85                  90                  95      





Tyr Ser Pro Leu Gly Gly Pro Lys Pro Phe Glu Cys Pro Ser Ile Gln 

            100                 105                 110         





Ile Thr Ser Ile Ser Pro Asn Cys His Gln Glu Leu Asp Ala His Glu 

        115                 120                 125             





Asp Asp Leu Gln Ile Asn Asp Pro Glu Arg Glu Phe Leu Glu Arg Pro 

    130                 135                 140                 





Ser Arg Asp His Leu Tyr Leu Pro Leu Glu Pro Ser Tyr Arg Glu Ser 

145                 150                 155                 160 





Ser Leu Ser Pro Ser Pro Ala Ser Ser Ile Ser Ser Arg Ser Trp Phe 

                165                 170                 175     





Ser Asp Ala Ser Ser Cys Glu Ser Leu Ser His Ile Tyr Asp Asp Val 

            180                 185                 190         





Asp Ser Glu Leu Asn Glu Ala Ala Ala Arg Phe Thr Leu Gly Ser Pro 

        195                 200                 205             





Leu Thr Ser Pro Gly Gly Ser Pro Gly Gly Cys Pro Gly Glu Glu Thr 

    210                 215                 220                 





Trp His Gln Gln Tyr Gly Leu Gly His Ser Leu Ser Pro Arg Gln Ser 

225                 230                 235                 240 





Pro Cys His Ser Pro Arg Ser Ser Val Thr Asp Glu Asn Trp Leu Ser 

                245                 250                 255     





Pro Arg Pro Ala Ser Gly Pro Ser Ser Arg Pro Thr Ser Pro Cys Gly 

            260                 265                 270         





Lys Arg Arg His Ser Ser Ala Glu Val Cys Tyr Ala Gly Ser Leu Ser 

        275                 280                 285             





Pro His His Ser Pro Val Pro Ser Pro Gly His Ser Pro Arg Gly Ser 

    290                 295                 300                 





Val Thr Glu Asp Thr Trp Leu Asn Ala Ser Val His Gly Gly Ser Gly 

305                 310                 315                 320 





Leu Gly Pro Ala Val Phe Pro Phe Gln Tyr Cys Val Glu Thr Asp Ile 

                325                 330                 335     





Pro Leu Lys Thr Arg Lys Thr Ser Glu Asp Gln Ala Ala Ile Leu Pro 

            340                 345                 350         





Gly Lys Leu Glu Leu Cys Ser Asp Asp Gln Gly Ser Leu Ser Pro Ala 

        355                 360                 365             





Arg Glu Thr Ser Ile Asp Asp Gly Leu Gly Ser Gln Tyr Pro Leu Lys 

    370                 375                 380                 





Lys Asp Ser Cys Gly Asp Gln Phe Leu Ser Val Pro Ser Pro Phe Thr 

385                 390                 395                 400 





Trp Ser Lys Pro Lys Pro Gly His Thr Pro Ile Phe Arg Thr Ser Ser 

                405                 410                 415     





Leu Pro Pro Leu Asp Trp Pro Leu Pro Ala His Phe Gly Gln Cys Glu 

            420                 425                 430         





Leu Lys Ile Glu Val Gln Pro Lys Thr His His Arg Ala His Tyr Glu 

        435                 440                 445             





Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ser Thr Gly Gly His Pro 

    450                 455                 460                 





Val Val Lys Leu Leu Gly Tyr Asn Glu Lys Pro Ile Asn Leu Gln Met 

465                 470                 475                 480 





Phe Ile Gly Thr Ala Asp Asp Arg Tyr Leu Arg Pro His Ala Phe Tyr 

                485                 490                 495     





Gln Val His Arg Ile Thr Gly Lys Thr Val Ala Thr Ala Ser Gln Glu 

            500                 505                 510         





Ile Ile Ile Ala Ser Thr Lys Val Leu Glu Ile Pro Leu Leu Pro Glu 

        515                 520                 525             





Asn Asn Met Ser Ala Ser Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg 

    530                 535                 540                 





Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys 

545                 550                 555                 560 





Asn Thr Arg Val Arg Leu Val Phe Arg Val His Ile Pro Gln Pro Ser 

                565                 570                 575     





Gly Lys Val Leu Ser Leu Gln Ile Ala Ser Ile Pro Val Glu Cys Ser 

            580                 585                 590         





Gln Arg Ser Ala Gln Glu Leu Pro His Ile Glu Lys Tyr Ser Ile Asn 

        595                 600                 605             





Ser Cys Ser Val Asn Gly Gly His Glu Met Val Val Thr Gly Ser Asn 

    610                 615                 620                 





Phe Leu Pro Glu Ser Lys Ile Ile Phe Leu Glu Lys Gly Gln Asp Gly 

625                 630                 635                 640 





Arg Pro Gln Trp Glu Val Glu Gly Lys Ile Ile Arg Glu Lys Cys Gln 

                645                 650                 655     





Gly Ala His Ile Val Leu Glu Val Pro Pro Tyr His Asn Pro Ala Val 

            660                 665                 670         





Thr Ala Ala Val Gln Val His Phe Tyr Leu Cys Asn Gly Lys Arg Lys 

        675                 680                 685             





Lys Ser Gln Ser Gln Arg Phe Thr Tyr Thr Pro Val Leu Met Lys Gln 

    690                 695                 700                 





Glu His Arg Glu Glu Ile Asp Leu Ser Ser Val Pro Ser Leu Pro Val 

705                 710                 715                 720 





Pro His Pro Ala Gln Thr Gln Arg Pro Ser Ser Asp Ser Gly Cys Ser 

                725                 730                 735     





His Asp Ser Val Leu Ser Gly Gln Arg Ser Leu Ile Cys Ser Ile Pro 

            740                 745                 750         





Gln Thr Tyr Ala Ser Met Val Thr Ser Ser His Leu Pro Gln Leu Gln 

        755                 760                 765             





Cys Arg Asp Glu Ser Val Ser Lys Glu Gln His Met Ile Pro Ser Pro 

    770                 775                 780                 





Ile Val His Gln Pro Phe Gln Val Thr Pro Thr Pro Pro Val Gly Ser 

785                 790                 795                 800 





Ser Tyr Gln Pro Met Gln Thr Asn Val Val Tyr Asn Gly Pro Thr Cys 

                805                 810                 815     





Leu Pro Ile Asn Ala Ala Ser Ser Gln Glu Phe Asp Ser Val Leu Phe 

            820                 825                 830         





Gln Gln Asp Ala Thr Leu Ser Gly Leu Val Asn Leu Gly Cys Gln Pro 

        835                 840                 845             





Leu Ser Ser Ile Pro Phe His Ser Ser Asn Ser Gly Ser Thr Gly His 

    850                 855                 860                 





Leu Leu Ala His Thr Pro His Ser Val His Thr Leu Pro His Leu Gln 

865                 870                 875                 880 





Ser Met Gly Tyr His Cys Ser Asn Thr Gly Gln Arg Ser Leu Ser Ser 

                885                 890                 895     





Pro Val Ala Asp Gln Ile Thr Gly Gln Pro Ser Ser Gln Leu Gln Pro 

            900                 905                 910         





Ile Thr Tyr Gly Pro Ser His Ser Gly Ser Ala Thr Thr Ala Ser Pro 

        915                 920                 925             





Ala Ala Ser His Pro Leu Ala Ser Ser Pro Leu Ser Gly Pro Pro Ser 

    930                 935                 940                 





Pro Gln Leu Gln Pro Met Pro Tyr Gln Ser Pro Ser Ser Gly Thr Ala 

945                 950                 955                 960 





Ser Ser Pro Ser Pro Ala Thr Arg Met His Ser Gly Gln His Ser Thr 

                965                 970                 975     





Gln Ala Gln Ser Thr Gly Gln Gly Gly Leu Ser Ala Pro Ser Ser Leu 

            980                 985                 990         





Ile Cys His Ser Leu Cys Asp Pro  Ala Ser Phe Pro Pro  Asp Gly Ala 

        995                 1000                 1005             





Thr Val  Ser Ile Lys Pro Glu  Pro Glu Asp Arg Glu  Pro Asn Phe 

    1010                 1015                 1020             





Ala Thr  Ile Gly Leu Gln Asp  Ile Thr Leu Asp Asp  Val Asn Glu 

    1025                 1030                 1035             





Ile Ile  Gly Arg Asp Met Ser  Gln Ile Ser Val Ser  Gln Gly Ala 

    1040                 1045                 1050             





Gly Val  Ser Arg Gln Ala Pro  Leu Pro Ser Pro Glu  Ser Leu Asp 

    1055                 1060                 1065             





Leu Gly  Arg Ser Asp Gly Leu  

    1070                 1075 





<210>  103

<211>  5672

<212>  DNA

<213>  Homo sapiens



<400>  103

aaccgtttag ttgctgggat ggggcggcgt tgggggtgcg gccctgaacc ggagggattt       60



agagactgga gacgcggcct ctaagagagg ttgaaactgt gtgtgtgtgg gagaaaatga      120



taaccaccct cccatctctc ctacccgcca gcctcgccag tatctcccac cgagtcacga      180



atctcccatc taactccctc tcacacaacc caggcctctc caagcctgac tttcccggaa      240



actccagtcc aggtcttcct tcctcctcca gcccaggccg ggacctgggg gctcctgccg      300



gatccatggg ggcggccagc tgcgaggatg aggagctgga atttaagctg gtgttcgggg      360



aggaaaagga ggcccccccg ctgggcgcgg ggggattggg ggaagaactg gactcagagg      420



atgccccgcc atgctgccgt ctggccttgg gagagccccc tccctatggc gctgcaccta      480



tcggtattcc ccgacctcca ccccctcggc ctggcatgca ttcgccaccg ccgcgaccag      540



ccccctcacc tggcacctgg gagagccagc ccgccaggtc ggtgaggctg ggaggaccag      600



gagggggtgc tgggggtgct gggggtggcc gtgttctcga gtgtcccagc atccgcatca      660



cctccatctc tcccacgccg gagccgccag cagcgctgga ggacaaccct gatgcctggg      720



gggacggctc tcctagagat taccccccac cagaaggctt tgggggctac agagaagcag      780



ggggccaggg tgggggggcc ttcttcagcc caagccctgg cagcagcagc ctgtcctcgt      840



ggagcttctt ctccgatgcc tctgacgagg cagccctgta tgcagcctgc gacgaggtgg      900



agtctgagct aaatgaggcg gcctcccgct ttggcctggg ctccccgctg ccctcgcccc      960



gggcctcccc tcggccatgg acccccgaag atccctggag cctgtatggt ccaagccccg     1020



gaggccgagg gccagaggat agctggctac tcctcagtgc tcctgggccc accccagcct     1080



ccccgcggcc tgcctctcca tgtggcaagc ggcgctattc cagctcggga accccatctt     1140



cagcctcccc agctctgtcc cgccgtggca gcctggggga agaggggtct gagccacctc     1200



caccaccccc attgcctctg gcccgggacc cgggctcccc tggtcccttt gactatgtgg     1260



gggccccacc agctgagagc atccctcaga agacacggcg gacttccagc gagcaggcag     1320



tggctctgcc tcggtctgag gagcctgcct catgcaatgg gaagctgccc ttgggagcag     1380



aggagtctgt ggctcctcca ggaggttccc ggaaggaggt ggctggcatg gactacctgg     1440



cagtgccctc cccactcgct tggtccaagg cccggattgg gggacacagc cctatcttca     1500



ggacctctgc cctaccccca ctggactggc ctctgcccag ccaatatgag cagctggagc     1560



tgaggatcga ggtacagcct agagcccacc accgggccca ctatgagaca gaaggcagcc     1620



gtggagctgt caaagctgcc cctggcggtc accccgtagt caagctccta ggctacagtg     1680



agaagccact gaccctacag atgttcatcg gcactgcaga tgaaaggaac ctgcggcctc     1740



atgccttcta tcaggtgcac cgtatcacag gcaagatggt ggccacggcc agctatgaag     1800



ccgtagtcag tggcaccaag gtgttggaga tgactctgct gcctgagaac aacatggcgg     1860



ccaacattga ctgcgcggga atcctgaagc ttcggaattc agacattgag cttcggaagg     1920



gtgagacgga catcgggcgc aaaaacacac gtgtacggct ggtgttccgg gtacacgtgc     1980



cccagggcgg cgggaaggtc gtctcagtac aggcagcatc ggtgcccatc gagtgctccc     2040



agcgctcagc ccaggagctg ccccaggtgg aggcctacag ccccagtgcc tgctctgtga     2100



gaggaggcga ggaactggta ctgactggct ccaacttcct gccagactcc aaggtggtgt     2160



tcattgagag gggtcctgat gggaagctgc aatgggagga ggaggccaca gtgaaccgac     2220



tgcagagcaa cgaggtgacg ctgaccctga ctgtccccga gtacagcaac aagagggttt     2280



cccggccagt ccaggtctac ttttatgtct ccaatgggcg gaggaaacgc agtcctaccc     2340



agagtttcag gtttctgcct gtgatctgca aagaggagcc cctaccggac tcatctctgc     2400



ggggtttccc ttcagcatcg gcaaccccct ttggcactga catggacttc tcaccaccca     2460



ggccccccta cccctcctat ccccatgaag accctgcttg cgaaactcct tacctatcag     2520



aaggcttcgg ctatggcatg ccccctctgt acccccagac ggggccccca ccatcctaca     2580



gaccgggcct gcggatgttc cctgagacta ggggtaccac aggttgtgcc caaccacctg     2640



cagtttcctt ccttccccgc cccttcccta gtgacccgta tggagggcgg ggctcctctt     2700



tctccctggg gctgccattc tctccgccag ccccctttcg gccgcctcct cttcctgcat     2760



ccccaccgct tgaaggcccc ttcccttccc agagtgatgt gcatccccta cctgctgagg     2820



gatacaataa ggtagggcca ggctatggcc ctggggaggg ggctccggag caggagaaat     2880



ccaggggtgg ctacagcagc ggcttccgag acagtgtccc tatccagggt atcacgctgg     2940



aggaaggtgg gtgtgggact gggggctgtg agtgtgagtg tgtgcaagag attgctctgc     3000



atgtttgctg agggctggag ctgggctttt cagagatcgg gcatccctgg tctctcaggg     3060



ccagttggag gttcccagga ggcatgttct tgatgcctgt ggctgcctga atccaattaa     3120



ctgaattctg aagagtgcat ggggtaactg tctcagcctt tctcctgtct ctgcctctgt     3180



cctctgctcc aaatcataaa atctcagagc tagaagcact ttcaagatca ttccatccag     3240



cgcattcaat ttgcaagttt aggcgttgag ttccagagag ggatggtagc ttgctgaggt     3300



cccagtcaag cacacttgcc attgcctcag ctttccccta aacacggtgt ctgtggtcag     3360



ggttggtgag gaggagcttt cctgttttgc ctctccttct tcccattggc tacacccatc     3420



tctggccctg ctgataccga ttcccctgac atttcaggct aagccagcag gaaagggcta     3480



ggacgggtgc ctgggagccc acatggaggg agttgggcaa gatttgattc ggagcaggtg     3540



tcaagacgtg ttggggaaac tgaggcccag tggaatagaa gccagtagag gaggaatcta     3600



gaggcctcct agattaagac ctgcctggaa tggattgggg gtgggtcttt ggaaaaggag     3660



gggacccacc tctagcccag tctctcaact gcccctcctt tacagtgagt gagatcattg     3720



gccgagacct gagtggcttc cctgcacctc ctggagaaga gcctcctgcc tgaaccacgt     3780



gaactgtcat cacctggcaa ccccagcccc agcctcagcc ctgccccctt tccctccttc     3840



ctggagtggt ggctacagaa gcttggggcc aaccctggct cctctttccc cagcttctgt     3900



ctgtctcact gtcttccctc ccctccccca gctgaggtgt ggccctcagg cctggtgctg     3960



ccttggaggg ctgggggaag gagtgtgtgg aggagggagg agggtgaaga ctgaggctag     4020



gtgccagaat ggactggagt gaaggcgtgt ctagagtgtg ggctggctgt tgtgctggaa     4080



agctggggac aggttgatgg taataaactg ctcaatgacc agtgcttcag gctccagagc     4140



tctttggaga gatgggttgg ggcagcttac tccagccctg gcccaaggag gcccagaagt     4200



tggaaagaga tggaatgtgg ctgggaacat tgcatcccaa agagcttctc agtggaggag     4260



gctggggaag gcatgagggg gctcagaggc tccttgactg ggaccaggat tgggggccag     4320



ggcttgagta ggcctctcca ctctcctcct tgggggtcca gattccttag gagctttggg     4380



atgaggccca ggaggctgca tttttccagg tccttagtct tgccaccaca cagatgattc     4440



tgattcatag ccaagatgag gacacactga tgtagctgat ctctcattta cagaggagga     4500



ttctaaagtt cagagaggga aaggggcttg cctgaggtca cgtagataat cagcagcaca     4560



ttgaacgctg cactcctggg ctcctgtccc cagcccccat tcagacacgc tgactcagga     4620



ggtccaggcc tctaaggctt ctctccctgg agtgagggtg gaggtgaggg agagctggca     4680



caagccctcc ctctggatcc tccactcctg gggattatga agatattctg gaaagatttg     4740



tgcttcagag gtagactgca gaaagcaaac agtctaccca gcagctctga atgtcacctg     4800



ccctggggct tacagcacta tatgagttcc tggcctatcc tgcaaatatg cccatgctgg     4860



ccttctaaat agctggtaca tccatcacca ctgacgggcc tggcctggaa acctggtttg     4920



tcccctgtct tgatggccta cgagaggcca agttccactg ggctgggaaa agtcactttg     4980



tctgtcttgt tcacctggag cctgacacac cgtaggtact gagtacaaat agcttgattt     5040



ggctaggctt ggctgcaggg ggacgtgcct aaaagacatt ccgggcattt gcacttggga     5100



aacttgcctc accttcaggc ttgtggggcc tctctatgcc caatgagtcc aggcagtcct     5160



agcaagtact caggagagca ggggtgggtg tgacagaggc tggctctgga ttgggggaca     5220



acagaaccag agtaactcct cgcctgttgc tgctttgcaa tgaatttcct ttacctttct     5280



ggaacacaag ctgctgtgaa ccaaactgat atcaagtgat tagctcaccg ggccttggtt     5340



gcttttcaaa gatccccttc agccccctgc cagagtcact gccccataat caccatgtca     5400



gaagggaccc tagggcattc gtgtcctatt tatcaatctt cagcaccacc tctaagatct     5460



ctgagagagg gtggatcagc ctctgtgtaa acaaaaagct gttaggactt gttgcctctc     5520



aaggtggact attctgtttt ctgccaggac actgccattc atgcattgtc agatatttat     5580



taaacagcag caaagtgcca gccaatttgt cctggaggaa ttcatagcct catggggcaa     5640



aagtaaataa acagcttatt acaattcaac aa                                   5672





<210>  104

<211>  964

<212>  PRT

<213>  Homo sapiens



<400>  104



Met Ile Thr Thr Leu Pro Ser Leu Leu Pro Ala Ser Leu Ala Ser Ile 

1               5                   10                  15      





Ser His Arg Val Thr Asn Leu Pro Ser Asn Ser Leu Ser His Asn Pro 

            20                  25                  30          





Gly Leu Ser Lys Pro Asp Phe Pro Gly Asn Ser Ser Pro Gly Leu Pro 

        35                  40                  45              





Ser Ser Ser Ser Pro Gly Arg Asp Leu Gly Ala Pro Ala Gly Ser Met 

    50                  55                  60                  





Gly Ala Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val Phe 

65                  70                  75                  80  





Gly Glu Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly Glu 

                85                  90                  95      





Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu Gly 

            100                 105                 110         





Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro Pro 

        115                 120                 125             





Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro Ser 

    130                 135                 140                 





Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly Gly 

145                 150                 155                 160 





Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu Cys 

                165                 170                 175     





Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro Ala 

            180                 185                 190         





Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg Asp 

        195                 200                 205             





Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly Gln 

    210                 215                 220                 





Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu Ser 

225                 230                 235                 240 





Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr Ala 

                245                 250                 255     





Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg Phe 

            260                 265                 270         





Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro Trp 

        275                 280                 285             





Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly Arg 

    290                 295                 300                 





Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr Pro 

305                 310                 315                 320 





Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser Ser 

                325                 330                 335     





Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly Ser 

            340                 345                 350         





Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro Leu 

        355                 360                 365             





Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala Pro 

    370                 375                 380                 





Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu Gln 

385                 390                 395                 400 





Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly Lys 

                405                 410                 415     





Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser Arg 

            420                 425                 430         





Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu Ala 

        435                 440                 445             





Trp Ser Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr Ser 

    450                 455                 460                 





Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln Leu 

465                 470                 475                 480 





Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His Tyr 

                485                 490                 495     





Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly His 

            500                 505                 510         





Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu Gln 

        515                 520                 525             





Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala Phe 

    530                 535                 540                 





Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser Tyr 

545                 550                 555                 560 





Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu Pro 

                565                 570                 575     





Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys Leu 

            580                 585                 590         





Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg 

        595                 600                 605             





Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln Gly 

    610                 615                 620                 





Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu Cys 

625                 630                 635                 640 





Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser Pro 

                645                 650                 655     





Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly Ser 

            660                 665                 670         





Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro Asp 

        675                 680                 685             





Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln Ser 

    690                 695                 700                 





Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys Arg 

705                 710                 715                 720 





Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg Arg 

                725                 730                 735     





Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys Lys 

            740                 745                 750         





Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala Ser 

        755                 760                 765             





Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro Pro 

    770                 775                 780                 





Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr Leu 

785                 790                 795                 800 





Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr Gly 

                805                 810                 815     





Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr Arg 

            820                 825                 830         





Gly Thr Thr Gly Cys Ala Gln Pro Pro Ala Val Ser Phe Leu Pro Arg 

        835                 840                 845             





Pro Phe Pro Ser Asp Pro Tyr Gly Gly Arg Gly Ser Ser Phe Ser Leu 

    850                 855                 860                 





Gly Leu Pro Phe Ser Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu Pro 

865                 870                 875                 880 





Ala Ser Pro Pro Leu Glu Gly Pro Phe Pro Ser Gln Ser Asp Val His 

                885                 890                 895     





Pro Leu Pro Ala Glu Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly Pro 

            900                 905                 910         





Gly Glu Gly Ala Pro Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser Ser 

        915                 920                 925             





Gly Phe Arg Asp Ser Val Pro Ile Gln Gly Ile Thr Leu Glu Glu Gly 

    930                 935                 940                 





Gly Cys Gly Thr Gly Gly Cys Glu Cys Glu Cys Val Gln Glu Ile Ala 

945                 950                 955                 960 





Leu His Val Cys 

                





<210>  105

<211>  4976

<212>  DNA

<213>  Homo sapiens



<400>  105

gaagagagga cagagggagg gagggtgggg gaggacgagg ggcgcgtggt tttcccatct       60



catccctgga ggaggggctg gagcatcccc ggcagccaat cagggacagg ctgggggggg      120



gaccgctttg aagaagtttg ggggaaaaaa gtttggaaaa gtttctataa taacgagggg      180



gcttctggag ggaggcggca gcgacggagg agggggcttc tcagagaaag ggagggaggg      240



agccacccgg gtgaagatac agcagcctcc tgaactcccc cctcccaccc aggccgggac      300



ctgggggctc ctgccggatc catgggggcg gccagctgcg aggatgagga gctggaattt      360



aagctggtgt tcggggagga aaaggaggcc cccccgctgg gcgcgggggg attgggggaa      420



gaactggact cagaggatgc cccgccatgc tgccgtctgg ccttgggaga gccccctccc      480



tatggcgctg cacctatcgg tattccccga cctccacccc ctcggcctgg catgcattcg      540



ccaccgccgc gaccagcccc ctcacctggc acctgggaga gccagcccgc caggtcggtg      600



aggctgggag gaccaggagg gggtgctggg ggtgctgggg gtggccgtgt tctcgagtgt      660



cccagcatcc gcatcacctc catctctccc acgccggagc cgccagcagc gctggaggac      720



aaccctgatg cctgggggga cggctctcct agagattacc ccccaccaga aggctttggg      780



ggctacagag aagcaggggg ccagggtggg ggggccttct tcagcccaag ccctggcagc      840



agcagcctgt cctcgtggag cttcttctcc gatgcctctg acgaggcagc cctgtatgca      900



gcctgcgacg aggtggagtc tgagctaaat gaggcggcct cccgctttgg cctgggctcc      960



ccgctgccct cgccccgggc ctcccctcgg ccatggaccc ccgaagatcc ctggagcctg     1020



tatggtccaa gccccggagg ccgagggcca gaggatagct ggctactcct cagtgctcct     1080



gggcccaccc cagcctcccc gcggcctgcc tctccatgtg gcaagcggcg ctattccagc     1140



tcgggaaccc catcttcagc ctccccagct ctgtcccgcc gtggcagcct gggggaagag     1200



gggtctgagc cacctccacc acccccattg cctctggccc gggacccggg ctcccctggt     1260



ccctttgact atgtgggggc cccaccagct gagagcatcc ctcagaagac acggcggact     1320



tccagcgagc aggcagtggc tctgcctcgg tctgaggagc ctgcctcatg caatgggaag     1380



ctgcccttgg gagcagagga gtctgtggct cctccaggag gttcccggaa ggaggtggct     1440



ggcatggact acctggcagt gccctcccca ctcgcttggt ccaaggcccg gattggggga     1500



cacagcccta tcttcaggac ctctgcccta cccccactgg actggcctct gcccagccaa     1560



tatgagcagc tggagctgag gatcgaggta cagcctagag cccaccaccg ggcccactat     1620



gagacagaag gcagccgtgg agctgtcaaa gctgcccctg gcggtcaccc cgtagtcaag     1680



ctcctaggct acagtgagaa gccactgacc ctacagatgt tcatcggcac tgcagatgaa     1740



aggaacctgc ggcctcatgc cttctatcag gtgcaccgta tcacaggcaa gatggtggcc     1800



acggccagct atgaagccgt agtcagtggc accaaggtgt tggagatgac tctgctgcct     1860



gagaacaaca tggcggccaa cattgactgc gcgggaatcc tgaagcttcg gaattcagac     1920



attgagcttc ggaagggtga gacggacatc gggcgcaaaa acacacgtgt acggctggtg     1980



ttccgggtac acgtgcccca gggcggcggg aaggtcgtct cagtacaggc agcatcggtg     2040



cccatcgagt gctcccagcg ctcagcccag gagctgcccc aggtggaggc ctacagcccc     2100



agtgcctgct ctgtgagagg aggcgaggaa ctggtactga ctggctccaa cttcctgcca     2160



gactccaagg tggtgttcat tgagaggggt cctgatggga agctgcaatg ggaggaggag     2220



gccacagtga accgactgca gagcaacgag gtgacgctga ccctgactgt ccccgagtac     2280



agcaacaaga gggtttcccg gccagtccag gtctactttt atgtctccaa tgggcggagg     2340



aaacgcagtc ctacccagag tttcaggttt ctgcctgtga tctgcaaaga ggagccccta     2400



ccggactcat ctctgcgggg tttcccttca gcatcggcaa ccccctttgg cactgacatg     2460



gacttctcac cacccaggcc cccctacccc tcctatcccc atgaagaccc tgcttgcgaa     2520



actccttacc tatcagaagg cttcggctat ggcatgcccc ctctgtaccc ccagacgggg     2580



cccccaccat cctacagacc gggcctgcgg atgttccctg agactagggg taccacaggt     2640



tgtgcccaac cacctgcagt ttccttcctt ccccgcccct tccctagtga cccgtatgga     2700



gggcggggct cctctttctc cctggggctg ccattctctc cgccagcccc ctttcggccg     2760



cctcctcttc ctgcatcccc accgcttgaa ggccccttcc cttcccagag tgatgtgcat     2820



cccctacctg ctgagggata caataaggta gggccaggct atggccctgg ggagggggct     2880



ccggagcagg agaaatccag gggtggctac agcagcggct tccgagacag tgtccctatc     2940



cagggtatca cgctggagga agtgagtgag atcattggcc gagacctgag tggcttccct     3000



gcacctcctg gagaagagcc tcctgcctga accacgtgaa ctgtcatcac ctggcaaccc     3060



cagccccagc ctcagccctg ccccctttcc ctccttcctg gagtggtggc tacagaagct     3120



tggggccaac cctggctcct ctttccccag cttctgtctg tctcactgtc ttccctcccc     3180



tcccccagct gaggtgtggc cctcaggcct ggtgctgcct tggagggctg ggggaaggag     3240



tgtgtggagg agggaggagg gtgaagactg aggctaggtg ccagaatgga ctggagtgaa     3300



ggcgtgtcta gagtgtgggc tggctgttgt gctggaaagc tggggacagg ttgatggtaa     3360



taaactgctc aatgaccagt gcttcaggct ccagagctct ttggagagat gggttggggc     3420



agcttactcc agccctggcc caaggaggcc cagaagttgg aaagagatgg aatgtggctg     3480



ggaacattgc atcccaaaga gcttctcagt ggaggaggct ggggaaggca tgagggggct     3540



cagaggctcc ttgactggga ccaggattgg gggccagggc ttgagtaggc ctctccactc     3600



tcctccttgg gggtccagat tccttaggag ctttgggatg aggcccagga ggctgcattt     3660



ttccaggtcc ttagtcttgc caccacacag atgattctga ttcatagcca agatgaggac     3720



acactgatgt agctgatctc tcatttacag aggaggattc taaagttcag agagggaaag     3780



gggcttgcct gaggtcacgt agataatcag cagcacattg aacgctgcac tcctgggctc     3840



ctgtccccag cccccattca gacacgctga ctcaggaggt ccaggcctct aaggcttctc     3900



tccctggagt gagggtggag gtgagggaga gctggcacaa gccctccctc tggatcctcc     3960



actcctgggg attatgaaga tattctggaa agatttgtgc ttcagaggta gactgcagaa     4020



agcaaacagt ctacccagca gctctgaatg tcacctgccc tggggcttac agcactatat     4080



gagttcctgg cctatcctgc aaatatgccc atgctggcct tctaaatagc tggtacatcc     4140



atcaccactg acgggcctgg cctggaaacc tggtttgtcc cctgtcttga tggcctacga     4200



gaggccaagt tccactgggc tgggaaaagt cactttgtct gtcttgttca cctggagcct     4260



gacacaccgt aggtactgag tacaaatagc ttgatttggc taggcttggc tgcaggggga     4320



cgtgcctaaa agacattccg ggcatttgca cttgggaaac ttgcctcacc ttcaggcttg     4380



tggggcctct ctatgcccaa tgagtccagg cagtcctagc aagtactcag gagagcaggg     4440



gtgggtgtga cagaggctgg ctctggattg ggggacaaca gaaccagagt aactcctcgc     4500



ctgttgctgc tttgcaatga atttccttta cctttctgga acacaagctg ctgtgaacca     4560



aactgatatc aagtgattag ctcaccgggc cttggttgct tttcaaagat ccccttcagc     4620



cccctgccag agtcactgcc ccataatcac catgtcagaa gggaccctag ggcattcgtg     4680



tcctatttat caatcttcag caccacctct aagatctctg agagagggtg gatcagcctc     4740



tgtgtaaaca aaaagctgtt aggacttgtt gcctctcaag gtggactatt ctgttttctg     4800



ccaggacact gccattcatg cattgtcaga tatttattaa acagcagcaa agtgccagcc     4860



aatttgtcct ggaggaattc atagcctcat ggggcaaaag taaataaaca gcttattaca     4920



attcaacaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa         4976





<210>  106

<211>  902

<212>  PRT

<213>  Homo sapiens



<400>  106



Met Gly Ala Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val 

1               5                   10                  15      





Phe Gly Glu Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly 

            20                  25                  30          





Glu Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu 

        35                  40                  45              





Gly Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro 

    50                  55                  60                  





Pro Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro 

65                  70                  75                  80  





Ser Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly 

                85                  90                  95      





Gly Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu 

            100                 105                 110         





Cys Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro 

        115                 120                 125             





Ala Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg 

    130                 135                 140                 





Asp Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly 

145                 150                 155                 160 





Gln Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu 

                165                 170                 175     





Ser Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr 

            180                 185                 190         





Ala Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg 

        195                 200                 205             





Phe Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro 

    210                 215                 220                 





Trp Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly 

225                 230                 235                 240 





Arg Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr 

                245                 250                 255     





Pro Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser 

            260                 265                 270         





Ser Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly 

        275                 280                 285             





Ser Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro 

    290                 295                 300                 





Leu Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala 

305                 310                 315                 320 





Pro Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu 

                325                 330                 335     





Gln Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly 

            340                 345                 350         





Lys Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser 

        355                 360                 365             





Arg Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu 

    370                 375                 380                 





Ala Trp Ser Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr 

385                 390                 395                 400 





Ser Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln 

                405                 410                 415     





Leu Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His 

            420                 425                 430         





Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly 

        435                 440                 445             





His Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu 

    450                 455                 460                 





Gln Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala 

465                 470                 475                 480 





Phe Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser 

                485                 490                 495     





Tyr Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu 

            500                 505                 510         





Pro Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys 

        515                 520                 525             





Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly 

    530                 535                 540                 





Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln 

545                 550                 555                 560 





Gly Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu 

                565                 570                 575     





Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser 

            580                 585                 590         





Pro Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly 

        595                 600                 605             





Ser Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro 

    610                 615                 620                 





Asp Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln 

625                 630                 635                 640 





Ser Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys 

                645                 650                 655     





Arg Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg 

            660                 665                 670         





Arg Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys 

        675                 680                 685             





Lys Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala 

    690                 695                 700                 





Ser Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro 

705                 710                 715                 720 





Pro Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr 

                725                 730                 735     





Leu Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr 

            740                 745                 750         





Gly Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr 

        755                 760                 765             





Arg Gly Thr Thr Gly Cys Ala Gln Pro Pro Ala Val Ser Phe Leu Pro 

    770                 775                 780                 





Arg Pro Phe Pro Ser Asp Pro Tyr Gly Gly Arg Gly Ser Ser Phe Ser 

785                 790                 795                 800 





Leu Gly Leu Pro Phe Ser Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu 

                805                 810                 815     





Pro Ala Ser Pro Pro Leu Glu Gly Pro Phe Pro Ser Gln Ser Asp Val 

            820                 825                 830         





His Pro Leu Pro Ala Glu Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly 

        835                 840                 845             





Pro Gly Glu Gly Ala Pro Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser 

    850                 855                 860                 





Ser Gly Phe Arg Asp Ser Val Pro Ile Gln Gly Ile Thr Leu Glu Glu 

865                 870                 875                 880 





Val Ser Glu Ile Ile Gly Arg Asp Leu Ser Gly Phe Pro Ala Pro Pro 

                885                 890                 895     





Gly Glu Glu Pro Pro Ala 

            900         





<210>  107

<211>  14185

<212>  DNA

<213>  Homo sapiens



<400>  107

tgcaacggaa acttttggct ccacgaacag aaaagcaaga gcaaaaactc agttaaatgc       60



gttcttcctc catctttgcc tagtccaaaa ggaaaaaaaa agaaacagaa aaaagaaaaa      120



ctgtttggaa gagtagcgtt gaggtttgct ttttacctgt ttttcctcta gaacagccag      180



gtggattcac atgatccaat tttttaattg tcttctatgt cccactccga ataacccgga      240



tgccccagca caatcagaga gatcgttttt tttaaaaaaa atttcagcct ccaaaggtag      300



gaggggagtg ttaggggaga aagtacttta attaaaaatc aataactcga ggtttttggg      360



atacggtttg ccatttccta attaagaaat gggtttgaca gtccctttgt acacactgct      420



atgcaaaccc caaagggttg gcggctgtcc gggcgatgac actccggtcc cctgcgagac      480



cccgggccag ccaggcccgt ccgccgccgg cctctggggt ccgtccccgg ctcgcgcaga      540



cctctcgctt ctctcggctc tgtctcctgc gctcagctct gctcggggcc ggccgcctca      600



ggctcgccgc caccaggtcg ttgcaaatac cttttccctc cccggggccc cagcgcgcgg      660



ccacctccca gcctcccccc ctcccaccct ggcagcgggg ccctttcccg gctcaggaac      720



agcagcagcc cgggccgcgc cggcaggaag cgaggcccat gttgctgctg ttccctggcg      780



cgcctccccg ccctccgggg gccgccacgg ctcttccgcg ctcccgggca cccccctccg      840



cgcctgcgct gtgccccacg ggggcggggc tcagattcct gtcagcggcg gcggcggtgg      900



cggcgaccgt cagttttcgc tgaggagaaa cacgaaacgg accctttggc tctccccctt      960



ccccttcccc gtcctgaacc cctctcctgg tcaccgagaa tcagtccccg tggagttccc     1020



cctccacctc gccatcgttt cctcggtcct cggcccagtg gaagtcacta ccctcgagga     1080



ggaggcagcg gcagccgccc tcgcgtcgcc gcccccggtt cggtgcccgc ggtcccggag     1140



aggaggtgcc gccgccaccg ccgctccccc cctcccgctg ccctcgggcc gggctgggtc     1200



gagctgcgat gccctcggac ttcatctcat tgctcagcgc ggacctagac ctggaatcgc     1260



ccaagtccct ctactcgcga gaatctgtct atgatcttct cccaaaggag ttacagttac     1320



ctccatctag agaaacatct gtagcatcaa tgagtcagac aagcggtggt gaggcaggct     1380



cgcctcctcc agctgttgtt gctgctggat ttgcctctga agcagggagt gtctgcatta     1440



aaaatgacct gtagttctct gcttcataga tgcttcttca gctccctcct cttcctccat     1500



gggcggtgct tgcagctcct ttaccacctc ttccagccct accatttatt ctacctcagt     1560



caccgacagc aaggctatgc aagtggagag ctgctcctca gccgtggggg taagtaacag     1620



aggggtaagt gaaaagcagt taaccagtaa cacagttcag cagcatccat caacaccgaa     1680



gaggcacaca gtcttgtaca tctcaccacc acctgaggac ttgctggata acagtcggat     1740



gtcctgccag gatgaggggt gtggattgga atctgagcag agctgcagta tgtggatgga     1800



ggattccccc tccaacttca gtaacatgag caccagttcc tacaatgata acactgaggt     1860



acctcgtaaa tcacgaaaac gaaatccaaa gcagaggccg ggggtcaaac gacgagattg     1920



tgaagaatct aatatggata tatttgatgc cgacagtgcc aaagcacctc actatgtgct     1980



ttctcagctt accacggaca acaaaggcaa ctcaaaagcg ggaaatggaa cattggaaaa     2040



ccaaaaagga actggagtaa agaagagccc tatgttgtgt ggacaatatc ctgttaaaag     2100



tgagggaaag gagctgaaga tagttgtaca acctgagaca cagcaccgag ctcggtacct     2160



gactgagggc agccgtggct cagtgaaaga tagaacacag caaggctttc ctacagtaaa     2220



gctggaaggc cataatgaac ctgtagtgtt gcaagtgttt gtgggcaacg actctggacg     2280



agtgaaacca catggatttt atcaggcctg cagagtaact ggacgaaata caactccttg     2340



caaagaagtg gacattgaag gcactactgt tatagaagtc ggccttgatc ctagcaacaa     2400



catgacactg gcggtggact gcgtagggat attgaaattg aggaatgctg atgtcgaagc     2460



cagaatagga attgctggtt ccaagaagaa aagcactcgt gccagattgg tttttcgagt     2520



taatatcatg aggaaagatg gctccacttt gacactgcaa acaccctctt ctccaatttt     2580



gtgtactcag ccagcaggag tgccagaaat cttaaagaaa agcttgcata gctgttcagt     2640



gaaaggagaa gaagaagtgt ttttaatcgg caagaacttt ctgaaaggaa ctaaagttat     2700



tttccaagaa aatgtttctg atgaaaactc ttggaagtca gaagctgaaa ttgatatgga     2760



actatttcat cagaatcatc ttattgtgaa ggttcctccc tatcatgacc aacatataac     2820



tttgcctgtg tcagtgggaa tatatgtagt gacaaatgct ggaagatctc atgatgttca     2880



accattcact tacactccag acccagcagc agctggtgct ttgaatgtaa atgtgaagaa     2940



ggaaatatct agtccagcaa gaccttgctc ttttgaagag gccatgaaag caatgaaaac     3000



tactggatgt aatttagata aggtaaatat tatccctaat gccctgatga ctccactcat     3060



accaagcagt atgattaaga gtgaagatgt tactccaatg gaagtaacag cagaaaaaag     3120



atcttccact atttttaaga ctacaaagtc tgttggatca actcagcaaa cattagaaaa     3180



catctcaaac atagcaggaa atggctcttt ttcatcacca tcatcttccc acctaccttc     3240



tgaaaatgaa aaacagcagc agattcagcc caaggcatac aacccagaga ccctgacaac     3300



tattcaaacc caggacatct cacagcctgg tacttttcca gcagtttctg cttctagtca     3360



gctgcccaac agcgatgcac tattgcagca ggctacacag tttcagacaa gagaaactca     3420



gtctagagag atattacagt cagatggtac agtggttaat ttgtcacaac tgactgaggc     3480



atcacaacaa cagcagcagt caccactaca agaacaagca cagactttac agcagcagat     3540



ttcatcaaat atttttccat caccaaatag tgtgagtcag cttcagaata ctattcagca     3600



gctgcaagca gggagtttca caggcagtac tgctagtggc agcagtggaa gtgttgactt     3660



ggtccaacaa gttttagagg cacagcagca gttatcttca gttttatttt ctgctccaga     3720



tggtaatgag aatgttcaag agcagcttag tgcagatatt tttcaacaag tcagtcaaat     3780



tcagagtggt gtaagccctg gaatgttttc ctcaacagag ccaacagtcc ataccagacc     3840



agataattta ttacctggaa gagctgaaag tgttcatcca cagtctgaaa acacgttatc     3900



taatcaacag cagcagcagc agcagcaaca gcaagtgatg gaatcttcag ccgcaatggt     3960



gatggagatg caacagagta tctgccaggc agctgcccag attcagtcag agttattccc     4020



ttcaactgct tcagcaaatg gaaaccttca gcaatcgcca gtttaccagc agacttctca     4080



catgatgagt gcattgtcta ccaatgagga tatgcaaatg cagtgtgaat tgttttcttc     4140



tcctcctgca gtttctggaa atgaaacttc tacaactacc acacagcagg ttgcaacccc     4200



tggcactacc atgtttcaga catcaagttc aggagatgga gaagaaactg gaacacaagc     4260



aaaacagatt cagaacagtg tctttcagac catggtccaa atgcaacata gtggggacaa     4320



tcaacctcaa gttaaccttt tttcatccac aaaaagtatg atgagtgttc agaatagtgg     4380



tacccaacaa caaggtaatg gtttattcca gcaagggaat gagatgatgt cacttcaatc     4440



tggaaatttt ttgcagcagt cttctcattc acaggcccaa ctttttcatc ctcaaaatcc     4500



tattgccgat gctcagaacc tttcccagga aactcaaggt tctctctttc atagtccaaa     4560



tcctattgtc cacagtcaga cttctacaac ctcctctgaa caaatgcagc ctccaatgtt     4620



tcactctcaa agtaccattg ctgtgttaca gggctcttca gttcctcaag accagcagtc     4680



aaccaacata tttctttccc agagtcccat gaataatctt cagactaaca cagtagccca     4740



agaagcattt tttgcagcac cgaactcaat ttctccactt cagtcaacat caaacagtga     4800



acaacaagct gctttccaac agcaagctcc aatatcacac atccagactc ctatgctttc     4860



ccaagaacag gcacaacccc cgcagcaggg tttatttcag cctcaggtgg ccctgggctc     4920



ccttccacct aatccaatgc ctcaaagcca acaaggaacc atgttccagt cacagcactc     4980



aatagttgcc atgcagagta actctccatc ccaggaacag cagcagcagc agcaacagca     5040



gcagcaacag cagcagcaac aacaacagag cattttattc agtaatcaga ataccatggc     5100



tacaatggcg tctccaaagc aaccaccacc aaacatgata ttcaacccaa atcaaaatcc     5160



aatggctaat caggagcaac agaaccagtc aatttttcac caacaaagta acatggcccc     5220



aatgaatcaa gagcaacagc ccatgcaatt tcagagtcag tccacagttt cctcacttca     5280



gaacccaggt cctacccagt cggaatcatc acagaccccc ttgttccata gctctcctca     5340



gattcagttg gtacaagggt cacctagttc tcaagagcag caagtaactc tcttcttatc     5400



tccagcatcc atgtctgcct tgcagaccag tataaatcaa caagatatgc aacagtctcc     5460



tctttattcc cctcagaaca acatgcctgg aattcaagga gccacatctt cgcctcaacc     5520



acaggctact ttatttcaca acacagcagg aggcacaatg aaccaactgc agaattctcc     5580



tggctcatct cagcagacat caggaatgtt cttatttggc attcaaaata actgtagtca     5640



gcttttaacc tctggaccag ctacattgcc tgatcagttg atggccataa gtcagccagg     5700



ccaaccacaa aacgagggcc agccacctgt gacaacactt ctttctcagc aaatgccaga     5760



gaattctcca ctggcatcct ctataaacac caaccagaac atcgaaaaga ttgatttgct     5820



tgtttcattg caaaaccaag ggaacaactt gactggctcc ttttaactgg atataaattc     5880



cacgaagaaa atcctgattc caagatgtcc tgagatcttg tggttccatg agaattatta     5940



ctttaaaaac aaaacaaaat ataaaaaact gtgtttgagt aaactgatag attttactct     6000



gactgcaaaa gagcacacct atgctgcttg ttgcagtaac taaccaccaa tgttaacatc     6060



ttcatatttt atattcctaa taacagtgat gactgagaat ctatttgagt ttccagctgg     6120



cagaattaat tgttattatt ttcctaggcg caatttcctt aaacgtacag tttaaattca     6180



aggctggacc actcagttat tattgctatt agaaaataat atatcatgtt tacttttgtt     6240



cttcattatt ttctttcctg cattgtttta gtcaagtaat ggcttttgaa aaagtaaagt     6300



tcaataataa ctaaggctgt gatttttttc aatataaaag gcacagctgt tggccaaagt     6360



gaaggaatct tttttcagtt ttattggaga aactgaaggg taacattcta acaagtaaac     6420



tgtatgtgca gataaaagta ctcttgattt aacacaaagg cagatgatac acttataaaa     6480



ctgggaacag ctggaatgct tcttgatttt attttttcag agagttgtta gttctctggg     6540



tttctactaa ggggtttagc cataactgtg catagaaaaa taattatctg taaaaaatga     6600



aggggataat atatgataaa ttatgttctg atatcctcct acagtagttt aaattgacag     6660



aaaaatttga atgttttctt cttaacccag tcttaggctg gtattccctt tttatatata     6720



tctatattac ttttcacctc tttttcactt tactttagag aactattaat atactactgg     6780



cttcatgacc ctgtagcatc tttggccact ttaatctagg gtgacctagc aatcctgcag     6840



cacagggcag agagtactgt cttaggaatt attaggagtt gattcctgag aaacaacaca     6900



tttttcccca tgaacggtgc tgttctgaag tcttcaaatt tttccctcta ataggaaaca     6960



gtataaattt taattaaaaa aaaaaggcaa actaaaattt cttgaaatat cacttctccc     7020



tgatctgcag tgagtataaa ttcacttgtc acctcagtgc tttacagttt gaagtggtca     7080



cttacctgat ggttcccaca agccttaggc tttacagggt tgtatcattg acttaaaatg     7140



aagaattaac ttgtgttaca tctataaaga gcaaaataac acactccaga acttggcagt     7200



tgtagcatta gttatacagt tttgggtgtt cttgccaccc gtgggatgcc tgcttctcac     7260



taccacctgt gtctggacac atgcttatgt ctcattttcc ttttggcatg tggaaagctg     7320



tcaatgcagt gtaaggccaa cgtgtgtgtg gcttctatgt gttgagataa tgttttggta     7380



tccttgtccg tttcatttat tttttaagtg tacaaaaaat aacctgttaa ttgttgaagg     7440



ctacttttct gttctttttt tttttttttt tctatcctgt acatttagtt gaactgtgcg     7500



gaattgtggt gttggttttg tttacacagc cagatttttc cttctttttg ttttgtgatg     7560



atcttccttt gttctttgaa tgtgctcttt tgtctttttc tcttttttct catgttttct     7620



tccctccacc tccacccctt tctttctttc tctctctgat tgagaggcat tgaattacgt     7680



tttcagtagt acaggcttct tgccgatatg aagggaactt ttcagaaaga gacctactct     7740



gggtcattta attttgaata cagttttcaa tcgttcaagt tttggatggt ttatatctaa     7800



tgtgtgtttc atttttttgg aaagctatat tttgtattta ggaaatggta tactattttg     7860



ctatttgtac tgagtgagta cattggcata aatatagaaa tttatatata tacatatata     7920



taaactattc ttttttgcca cacatttttg tggtaaattt gtgagtttgt ctgatgttct     7980



accacaacgt ggcgtctgat aacagtgagg gggggtgggg tttgttatgt ctttattgag     8040



tatttaagta tcttttgaaa caaatgacct gttcatctgt ggccattcca tcaggcagtt     8100



agttccttga tgtcagtagt gggctaaagg cagcttactg tgtgtttgct ggagctttca     8160



ctcagccaag tgttagagtc aggaaaccca ttgaggcaat ggcgtcaaat ggtgtttcac     8220



aagaatgagc cattcagtct ttgctcacta tatatttaat attttattat tgttgttatt     8280



gttattatta attggctttc tgtattctat gccttttatt tataaagaca ctaagaaaac     8340



ccatgtttgt aattttaata acatttttcc catcttgtaa tatccagagc tactttataa     8400



attctctgaa ccaaaagtat tttcctcagt gtatctcttc tcccccagcc cctattggga     8460



aaaattaccc agtatagttc aggttatgag gaggatcagc cacacaatcc agtgcttcag     8520



tttgaaaatg taaaattcta accctaaagt agggttggtt gaaatttcag acaaagcaaa     8580



cccagcaggt ataaaaagta gtataaatac aaatctgtaa gttatttttg aattttctga     8640



acttttttct aagagattac ataggagact aaagaaatct atctgttcaa gttctaatta     8700



ggatgattgt taatactgca ctgtggatga agtggcgact ggcttgtgtg ctgacttctg     8760



tggtttagca agaggtttat tgttatcaaa tgctaattgg caatgccaag tcactgggac     8820



caattttctg ttttataata tctaagttta gaacagaata tatacctgaa ctgtagtggt     8880



ttgatcggat ggagacagaa aacccgattt ttattctcat aaattttgtg gttatttata     8940



caagggctgt gctatgctac catattcttg ttcaataata ataggtttgt tgtttttttt     9000



acattgttaa atgttcctta cccctaaagg tcaatgttaa gtacaacatt ctgaaaatac     9060



aatttggcta cgaagagtat tcatcttctt tgaagctcag tggttgatat ttgtgctaat     9120



aatgcaattt cctgattact gttacaagtt atagctacat atgggagaga ctcagtgagc     9180



cagcaaaggc catagaaaca acaatttatt aaatgtattt atggcagaag gacctaaata     9240



aactgtgagc caccttttct tctttatatt gttacattta agtgttcttg ctttcagcaa     9300



ctcacattaa tgcttggagc ttatctcttt ctctctctct ctctctctct ctgtgtgtgt     9360



gtgtgtatgt gtgtgtgtgt gtgtgtgtgt ttccttattg tcattccatt atatatccac     9420



accaacatgg gtgacgataa ttcaaagtca tattttgcct ctaagcttga tcatgttacc     9480



tttatgatta aagtatcatg ttatttagcc aatgcaaatc tgttttaaaa caaatagttt     9540



aaaaaaagaa caagttttta agggctttat tatagaagaa gtattaatga aggactttcc     9600



ttcctccctc cctttcctcc cctccctgcc tcccttcttc ccttccatct ccccctcctc     9660



cctgccttct ttgtttctcc ttcccttatt cctccctccc tcctttctcc cttccttcct     9720



ttcttccatt catccttcct tgccttttat ttttattttt tgtaatatca catgtgctgt     9780



agtttggaat tttattctag tgcatttctt gctcatcaga acctcagcta atctacctag     9840



gaaaaatagt atcaaaggaa atgagaaagt tgtatctgag tccctccaga actaagataa     9900



ttctttttga ccatttaagc ctttataaat gcgttttgac catttaagcc tttataaatg     9960



cttgttttag gaaagtgaat ctgttagatg catcaacaaa taatgaccag gacaaaacga    10020



tttaataatt aaagtctcaa atcaccatgg ttatacattt tcaccagaaa tagtaatctt    10080



acaatttttc atttttctga tgaagatttc tgttccaata tctgtttcct aatagatttt    10140



ttaaattaat tagctttcct ctgctttatg accacaggtt ttatccctaa ccgagacagc    10200



tgtcttatat ctgcatgcct tagactgtgt ggagggactc catgaagaaa gaccataggt    10260



tagaaaaata actcatagta tataccctag taagtgggtt agtagaatct cataacatgt    10320



attaaaaaga ggttttcttc tctgcttgtt tgtgtcacta gagcaaaatt gtagagataa    10380



tgctcataat gcagtaaata tcagaataat atctacaata tcatttgtgg atggtcccag    10440



gtcccagtgc tctagttact ttacttcttt tttttttttt gagatggagt cttgctctgt    10500



ctctcaggct agagcagtgt gcgatctcag ctcactgcag cctccacctc ccaggttcaa    10560



gcgattctcc tgcctcagcc tcccaagtag ccaggattac aggcaccctc cactaggccc    10620



ggctaatttt ttttgtattt ttttagtaga gatggggttt tgccatgttg gccaggctgg    10680



tttcgaactc ctaacctcca gtgatccacc tgcctcggcg tcccaaagtg ctaggattac    10740



aggcatgagc caccacatcc ggcctaatta cttctttaat ccccatttat ttttatgcca    10800



ttctagcctc atttattaat aaaattatgt ttttactttc tctttcagga aattttttaa    10860



attaatattt tatatctaga tctaatgcta tggaaaagtg cctttttatc atttataatt    10920



tcatttttca ctatttccaa aaacacataa acaaatagtt tcagtaggtc ccagctttta    10980



ctttttccat ttaaaccttc ttttctccat ttcttccctt tggcttaaga ataaaagaaa    11040



aggtacattg ctagaattgt ttctttggga gagggtaaaa gattacagaa ttagactgtt    11100



cagcctttat ataaactaaa tttgtcttca tctcaaccag ctaatggtag gtcttatctg    11160



aatactcatg agaattttag catctgtgaa actccatgca ccagatgtgt gtaaatttca    11220



ggaagaaagt gttgaaagca ttttctctga tgttaattag atggaaataa atcactaaaa    11280



catagtttag gtaaagcctg attatgccac ttttttttaa ctagacaggg caaagttgtt    11340



tatgttagtg tacttcttgt ctatcctcag ttaatttacc tagacaaaaa gtgtcaaagg    11400



aaatgagaaa aaggttatat ctgactccct ccagacctaa gataattcct tttgatcaga    11460



tacagtcaga tggagtgcct tggtttttgt taattttgcc tctattccag ctccttacca    11520



cagcggtggt gcttaaagaa aggatcatca gcaacaggtc aggatagttc tacctttggg    11580



atagggctgc tttccccgtg ctagtatttc tgtgactgtt agtggcactg aggactgcaa    11640



acttttatgc aatattctta ataccctatt gatattatgc actttaatca ttccaaagaa    11700



gccaagaatg ctgtatagtg atgattcctt cctaatgaat tcatcttaac tatttagaat    11760



gttatgtccc ttttcttttg gatagccaac ttggtataaa tgttatatgg atttttctaa    11820



aatgactata taggacttaa gactttgaaa tgtaatttac ttataagggg aaataattat    11880



gctttagcac atcattttag aaacgtcaca ttttagaaac attcagcttg ctaacctaca    11940



tgtttgggaa ttcattaaaa ccagttgtct atatattttg tgccatgtat ataagaacat    12000



tacaatatat ctttttctac atatgtagta tgtgcaacca gtggttctca gagtatggtt    12060



ctcagcccac cagctagtat cagtatcacc tgggaactag ttagaaatgt aaattctttg    12120



gccccatccc agacatactg agtcagaaac tctggaatag ggcccccgca atctgttttc    12180



acaagccctc caggtgattc tgatgcacac tttaaagttt aggaaccact gggctaagac    12240



tctgttgaga tatagagttt ttcttccact cagactgata tagttataca ttgttcttca    12300



tgtaaattca gcttaacctg gttatctata atcttttatt ggcaaaagtt aattctcagt    12360



actgcctata gagatacagt gtattttatg tacatacaca attagtctaa ttcttgataa    12420



ttcagttaat ttagtttggc attttcctac cacttactaa aaggtttaca ttaaatgact    12480



gatttaaata tataggtgca atgttctatg tttattttaa ttgttatgac atttaagtag    12540



ctaatataat tgaccggtgc taaagtctcc tgtttatcca taaaatgggt acattatggg    12600



cagtgtaata caagctttct tttcattgcc tagtacttta ccagcagacc acagttttgc    12660



cctggctaga ccaaccctca gaacaaaatc atcattcctt gtatttatat ttgtatctga    12720



gatagtaaac aagatggctg gccaggtcaa catggcacct taacttattt ttttaatagg    12780



taaaacttct tcaaaagtag cttgctttgt ataagaacta agctatcagt atagatatag    12840



ctatccttgg agcttatgtt tcagacaaga attatttact aaaataaata ataaacaaga    12900



taatgcatta tacaatttgg gcatttctcg tttctcaagt gtatgcatca tggtaaatat    12960



aaactaacca caagataggt agattgattc atttcatttt aatctccttg tgtaattcag    13020



tacctccata attgttctaa tcttcttccc actgtttaca aattaccagt taattaactc    13080



gtgaaagaaa aattcacata tcagaataaa aataaatgta tactcacttt ataaaaatca    13140



ccactgctgt ctttccttaa tactagcagt ggaaatgtaa gtggcttact ctacaaattt    13200



tggtgctggc aaatacatag gcaaactgtt gggagctgct ctagttacat tcctcccttc    13260



ttattccctt tttctcttcc tcactttatt gcataacata ttcctgtacc caaagcattc    13320



taccacagtt ctatttgact cccacttgta ataactcctt taaaaaattc catgtttaac    13380



catatgaccc tgcttgctta ctcatattct ccctccctct ccccttcctt tctctctctt    13440



ccagaagtca tttgcctggt ttgaaatatt ttgtagggat tgcttattat attattttag    13500



ctgatgaacc tcaggacaac gtctacacac acacacatac atacacgcac acaaaatctc    13560



agctgttgaa gagtgggctt ggaatcagac ttctgtgtcc agtaaaaaac tcctgcactg    13620



aagtcattgt gacttgagta gttacagact gattccagtg aacttgatct aatttctttt    13680



gatctaatga atgtgtctgc ttaccttgtt tccttttaat tgataagctc caagtagttg    13740



ctaatttttt gacaacttta aatgagtttc attcacttct tttacttaat gttttaagta    13800



tagtaccaat aatttcatta acctgttctc aagtggttta gctaccattc tgccattttt    13860



aatttttatt taattttatt tgcttgagca cactgatcaa ccactgaact gccttcttcc    13920



attgtcctgc aatgatataa gggttacatt tttgtgtata tggctttcat agttgggatt    13980



tcagagcact gataccagat attttcagtt tgttctctgg gggaatttca tttgcatcta    14040



tgtttttagc tatctgtgat aacttgttaa atattaaaaa gatattttgc ttctattgga    14100



acatttgtat actcgcaact atatttctgt aaacagctgc agtcaaaaat aaaacactga    14160



aagttaaaaa aaaaaaaaaa aaaaa                                          14185





<210>  108

<211>  1455

<212>  PRT

<213>  Homo sapiens



<400>  108



Met Gly Gly Ala Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile 

1               5                   10                  15      





Tyr Ser Thr Ser Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys 

            20                  25                  30          





Ser Ser Ala Val Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu 

        35                  40                  45              





Thr Ser Asn Thr Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr 

    50                  55                  60                  





Val Leu Tyr Ile Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg 

65                  70                  75                  80  





Met Ser Cys Gln Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys 

                85                  90                  95      





Ser Met Trp Met Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr 

            100                 105                 110         





Ser Ser Tyr Asn Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg 

        115                 120                 125             





Asn Pro Lys Gln Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser 

    130                 135                 140                 





Asn Met Asp Ile Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val 

145                 150                 155                 160 





Leu Ser Gln Leu Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn 

                165                 170                 175     





Gly Thr Leu Glu Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met 

            180                 185                 190         





Leu Cys Gly Gln Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile 

        195                 200                 205             





Val Val Gln Pro Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly 

    210                 215                 220                 





Ser Arg Gly Ser Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val 

225                 230                 235                 240 





Lys Leu Glu Gly His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly 

                245                 250                 255     





Asn Asp Ser Gly Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg 

            260                 265                 270         





Val Thr Gly Arg Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly 

        275                 280                 285             





Thr Thr Val Ile Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu 

    290                 295                 300                 





Ala Val Asp Cys Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu 

305                 310                 315                 320 





Ala Arg Ile Gly Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg 

                325                 330                 335     





Leu Val Phe Arg Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr 

            340                 345                 350         





Leu Gln Thr Pro Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val 

        355                 360                 365             





Pro Glu Ile Leu Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu 

    370                 375                 380                 





Glu Glu Val Phe Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val 

385                 390                 395                 400 





Ile Phe Gln Glu Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala 

                405                 410                 415     





Glu Ile Asp Met Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val 

            420                 425                 430         





Pro Pro Tyr His Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile 

        435                 440                 445             





Tyr Val Val Thr Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr 

    450                 455                 460                 





Tyr Thr Pro Asp Pro Ala Ala Ala Gly Ala Leu Asn Val Asn Val Lys 

465                 470                 475                 480 





Lys Glu Ile Ser Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met 

                485                 490                 495     





Lys Ala Met Lys Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile 

            500                 505                 510         





Pro Asn Ala Leu Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser 

        515                 520                 525             





Glu Asp Val Thr Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr 

    530                 535                 540                 





Ile Phe Lys Thr Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu 

545                 550                 555                 560 





Asn Ile Ser Asn Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser 

                565                 570                 575     





Ser His Leu Pro Ser Glu Asn Glu Lys Gln Gln Gln Ile Gln Pro Lys 

            580                 585                 590         





Ala Tyr Asn Pro Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser 

        595                 600                 605             





Gln Pro Gly Thr Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn 

    610                 615                 620                 





Ser Asp Ala Leu Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr 

625                 630                 635                 640 





Gln Ser Arg Glu Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser 

                645                 650                 655     





Gln Leu Thr Glu Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu 

            660                 665                 670         





Gln Ala Gln Thr Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser 

        675                 680                 685             





Pro Asn Ser Val Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala 

    690                 695                 700                 





Gly Ser Phe Thr Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp 

705                 710                 715                 720 





Leu Val Gln Gln Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu 

                725                 730                 735     





Phe Ser Ala Pro Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala 

            740                 745                 750         





Asp Ile Phe Gln Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly 

        755                 760                 765             





Met Phe Ser Ser Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu 

    770                 775                 780                 





Leu Pro Gly Arg Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu 

785                 790                 795                 800 





Ser Asn Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser 

                805                 810                 815     





Ser Ala Ala Met Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala 

            820                 825                 830         





Ala Gln Ile Gln Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly 

        835                 840                 845             





Asn Leu Gln Gln Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser 

    850                 855                 860                 





Ala Leu Ser Thr Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser 

865                 870                 875                 880 





Ser Pro Pro Ala Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln 

                885                 890                 895     





Gln Val Ala Thr Pro Gly Thr Thr Met Phe Gln Thr Ser Ser Ser Gly 

            900                 905                 910         





Asp Gly Glu Glu Thr Gly Thr Gln Ala Lys Gln Ile Gln Asn Ser Val 

        915                 920                 925             





Phe Gln Thr Met Val Gln Met Gln His Ser Gly Asp Asn Gln Pro Gln 

    930                 935                 940                 





Val Asn Leu Phe Ser Ser Thr Lys Ser Met Met Ser Val Gln Asn Ser 

945                 950                 955                 960 





Gly Thr Gln Gln Gln Gly Asn Gly Leu Phe Gln Gln Gly Asn Glu Met 

                965                 970                 975     





Met Ser Leu Gln Ser Gly Asn Phe Leu Gln Gln Ser Ser His Ser Gln 

            980                 985                 990         





Ala Gln Leu Phe His Pro Gln Asn  Pro Ile Ala Asp Ala  Gln Asn Leu 

        995                 1000                 1005             





Ser Gln  Glu Thr Gln Gly Ser  Leu Phe His Ser Pro  Asn Pro Ile 

    1010                 1015                 1020             





Val His  Ser Gln Thr Ser Thr  Thr Ser Ser Glu Gln  Met Gln Pro 

    1025                 1030                 1035             





Pro Met  Phe His Ser Gln Ser  Thr Ile Ala Val Leu  Gln Gly Ser 

    1040                 1045                 1050             





Ser Val  Pro Gln Asp Gln Gln  Ser Thr Asn Ile Phe  Leu Ser Gln 

    1055                 1060                 1065             





Ser Pro  Met Asn Asn Leu Gln  Thr Asn Thr Val Ala  Gln Glu Ala 

    1070                 1075                 1080             





Phe Phe  Ala Ala Pro Asn Ser  Ile Ser Pro Leu Gln  Ser Thr Ser 

    1085                 1090                 1095             





Asn Ser  Glu Gln Gln Ala Ala  Phe Gln Gln Gln Ala  Pro Ile Ser 

    1100                 1105                 1110             





His Ile  Gln Thr Pro Met Leu  Ser Gln Glu Gln Ala  Gln Pro Pro 

    1115                 1120                 1125             





Gln Gln  Gly Leu Phe Gln Pro  Gln Val Ala Leu Gly  Ser Leu Pro 

    1130                 1135                 1140             





Pro Asn  Pro Met Pro Gln Ser  Gln Gln Gly Thr Met  Phe Gln Ser 

    1145                 1150                 1155             





Gln His  Ser Ile Val Ala Met  Gln Ser Asn Ser Pro  Ser Gln Glu 

    1160                 1165                 1170             





Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 

    1175                 1180                 1185             





Gln Gln  Ser Ile Leu Phe Ser  Asn Gln Asn Thr Met  Ala Thr Met 

    1190                 1195                 1200             





Ala Ser  Pro Lys Gln Pro Pro  Pro Asn Met Ile Phe  Asn Pro Asn 

    1205                 1210                 1215             





Gln Asn  Pro Met Ala Asn Gln  Glu Gln Gln Asn Gln  Ser Ile Phe 

    1220                 1225                 1230             





His Gln  Gln Ser Asn Met Ala  Pro Met Asn Gln Glu  Gln Gln Pro 

    1235                 1240                 1245             





Met Gln  Phe Gln Ser Gln Ser  Thr Val Ser Ser Leu  Gln Asn Pro 

    1250                 1255                 1260             





Gly Pro  Thr Gln Ser Glu Ser  Ser Gln Thr Pro Leu  Phe His Ser 

    1265                 1270                 1275             





Ser Pro  Gln Ile Gln Leu Val  Gln Gly Ser Pro Ser  Ser Gln Glu 

    1280                 1285                 1290             





Gln Gln  Val Thr Leu Phe Leu  Ser Pro Ala Ser Met  Ser Ala Leu 

    1295                 1300                 1305             





Gln Thr  Ser Ile Asn Gln Gln  Asp Met Gln Gln Ser  Pro Leu Tyr 

    1310                 1315                 1320             





Ser Pro  Gln Asn Asn Met Pro  Gly Ile Gln Gly Ala  Thr Ser Ser 

    1325                 1330                 1335             





Pro Gln  Pro Gln Ala Thr Leu  Phe His Asn Thr Ala  Gly Gly Thr 

    1340                 1345                 1350             





Met Asn  Gln Leu Gln Asn Ser  Pro Gly Ser Ser Gln  Gln Thr Ser 

    1355                 1360                 1365             





Gly Met  Phe Leu Phe Gly Ile  Gln Asn Asn Cys Ser  Gln Leu Leu 

    1370                 1375                 1380             





Thr Ser  Gly Pro Ala Thr Leu  Pro Asp Gln Leu Met  Ala Ile Ser 

    1385                 1390                 1395             





Gln Pro  Gly Gln Pro Gln Asn  Glu Gly Gln Pro Pro  Val Thr Thr 

    1400                 1405                 1410             





Leu Leu  Ser Gln Gln Met Pro  Glu Asn Ser Pro Leu  Ala Ser Ser 

    1415                 1420                 1425             





Ile Asn  Thr Asn Gln Asn Ile  Glu Lys Ile Asp Leu  Leu Val Ser 

    1430                 1435                 1440             





Leu Gln  Asn Gln Gly Asn Asn  Leu Thr Gly Ser Phe  

    1445                 1450                 1455 





<210>  109

<211>  14174

<212>  DNA

<213>  Homo sapiens



<400>  109

tgcaacggaa acttttggct ccacgaacag aaaagcaaga gcaaaaactc agttaaatgc       60



gttcttcctc catctttgcc tagtccaaaa ggaaaaaaaa agaaacagaa aaaagaaaaa      120



ctgtttggaa gagtagcgtt gaggtttgct ttttacctgt ttttcctcta gaacagccag      180



gtggattcac atgatccaat tttttaattg tcttctatgt cccactccga ataacccgga      240



tgccccagca caatcagaga gatcgttttt tttaaaaaaa atttcagcct ccaaaggtag      300



gaggggagtg ttaggggaga aagtacttta attaaaaatc aataactcga ggtttttggg      360



atacggtttg ccatttccta attaagaaat gggtttgaca gtccctttgt acacactgct      420



atgcaaaccc caaagggttg gcggctgtcc gggcgatgac actccggtcc cctgcgagac      480



cccgggccag ccaggcccgt ccgccgccgg cctctggggt ccgtccccgg ctcgcgcaga      540



cctctcgctt ctctcggctc tgtctcctgc gctcagctct gctcggggcc ggccgcctca      600



ggctcgccgc caccaggtcg ttgcaaatac cttttccctc cccggggccc cagcgcgcgg      660



ccacctccca gcctcccccc ctcccaccct ggcagcgggg ccctttcccg gctcaggaac      720



agcagcagcc cgggccgcgc cggcaggaag cgaggcccat gttgctgctg ttccctggcg      780



cgcctccccg ccctccgggg gccgccacgg ctcttccgcg ctcccgggca cccccctccg      840



cgcctgcgct gtgccccacg ggggcggggc tcagattcct gtcagcggcg gcggcggtgg      900



cggcgaccgt cagttttcgc tgaggagaaa cacgaaacgg accctttggc tctccccctt      960



ccccttcccc gtcctgaacc cctctcctgg tcaccgagaa tcagtccccg tggagttccc     1020



cctccacctc gccatcgttt cctcggtcct cggcccagtg gaagtcacta ccctcgagga     1080



ggaggcagcg gcagccgccc tcgcgtcgcc gcccccggtt cggtgcccgc ggtcccggag     1140



aggaggtgcc gccgccaccg ccgctccccc cctcccgctg ccctcgggcc gggctgggtc     1200



gagctgcgat gccctcggac ttcatctcat tgctcagcgc ggacctagac ctggaatcgc     1260



ccaagtccct ctactcgcga gattctctga agttacaccc atcacagaat tttcatagag     1320



ctggactatt ggaagaatct gtctatgatc ttctcccaaa ggagttacag ttacctccat     1380



ctagagaaac atctgtagca tcaatgagtc agacaagcgg tggtgaggca ggctcgcctc     1440



ctccagctgt tgttgctgct gatgcttctt cagctccctc ctcttcctcc atgggcggtg     1500



cttgcagctc ctttaccacc tcttccagcc ctaccattta ttctacctca gtcaccgaca     1560



gcaaggctat gcaagtggag agctgctcct cagccgtggg ggtaagtaac agaggggtaa     1620



gtgaaaagca gttaaccagt aacacagttc agcagcatcc atcaacaccg aagaggcaca     1680



cagtcttgta catctcacca ccacctgagg acttgctgga taacagtcgg atgtcctgcc     1740



aggatgaggg gtgtggattg gaatctgagc agagctgcag tatgtggatg gaggattccc     1800



cctccaactt cagtaacatg agcaccagtt cctacaatga taacactgag gtacctcgta     1860



aatcacgaaa acgaaatcca aagcagaggc cgggggtcaa acgacgagat tgtgaagaat     1920



ctaatatgga tatatttgat gccgacagtg ccaaagcacc tcactatgtg ctttctcagc     1980



ttaccacgga caacaaaggc aactcaaaag cgggaaatgg aacattggaa aaccaaaaag     2040



gaactggagt aaagaagagc cctatgttgt gtggacaata tcctgttaaa agtgagggaa     2100



aggagctgaa gatagttgta caacctgaga cacagcaccg agctcggtac ctgactgagg     2160



gcagccgtgg ctcagtgaaa gatagaacac agcaaggctt tcctacagta aagctggaag     2220



gccataatga acctgtagtg ttgcaagtgt ttgtgggcaa cgactctgga cgagtgaaac     2280



cacatggatt ttatcaggcc tgcagagtaa ctggacgaaa tacaactcct tgcaaagaag     2340



tggacattga aggcactact gttatagaag tcggccttga tcctagcaac aacatgacac     2400



tggcggtgga ctgcgtaggg atattgaaat tgaggaatgc tgatgtcgaa gccagaatag     2460



gaattgctgg ttccaagaag aaaagcactc gtgccagatt ggtttttcga gttaatatca     2520



tgaggaaaga tggctccact ttgacactgc aaacaccctc ttctccaatt ttgtgtactc     2580



agccagcagg agtgccagaa atcttaaaga aaagcttgca tagctgttca gtgaaaggag     2640



aagaagaagt gtttttaatc ggcaagaact ttctgaaagg aactaaagtt attttccaag     2700



aaaatgtttc tgatgaaaac tcttggaagt cagaagctga aattgatatg gaactatttc     2760



atcagaatca tcttattgtg aaggttcctc cctatcatga ccaacatata actttgcctg     2820



tgtcagtggg aatatatgta gtgacaaatg ctggaagatc tcatgatgtt caaccattca     2880



cttacactcc agacccagca gctggtgctt tgaatgtaaa tgtgaagaag gaaatatcta     2940



gtccagcaag accttgctct tttgaagagg ccatgaaagc aatgaaaact actggatgta     3000



atttagataa ggtaaatatt atccctaatg ccctgatgac tccactcata ccaagcagta     3060



tgattaagag tgaagatgtt actccaatgg aagtaacagc agaaaaaaga tcttccacta     3120



tttttaagac tacaaagtct gttggatcaa ctcagcaaac attagaaaac atctcaaaca     3180



tagcaggaaa tggctctttt tcatcaccat catcttccca cctaccttct gaaaatgaaa     3240



aacagcagca gattcagccc aaggcataca acccagagac cctgacaact attcaaaccc     3300



aggacatctc acagcctggt acttttccag cagtttctgc ttctagtcag ctgcccaaca     3360



gcgatgcact attgcagcag gctacacagt ttcagacaag agaaactcag tctagagaga     3420



tattacagtc agatggtaca gtggttaatt tgtcacaact gactgaggca tcacaacaac     3480



agcagcagtc accactacaa gaacaagcac agactttaca gcagcagatt tcatcaaata     3540



tttttccatc accaaatagt gtgagtcagc ttcagaatac tattcagcag ctgcaagcag     3600



ggagtttcac aggcagtact gctagtggca gcagtggaag tgttgacttg gtccaacaag     3660



ttttagaggc acagcagcag ttatcttcag ttttattttc tgctccagat ggtaatgaga     3720



atgttcaaga gcagcttagt gcagatattt ttcaacaagt cagtcaaatt cagagtggtg     3780



taagccctgg aatgttttcc tcaacagagc caacagtcca taccagacca gataatttat     3840



tacctggaag agctgaaagt gttcatccac agtctgaaaa cacgttatct aatcaacagc     3900



agcagcagca gcagcaacag caagtgatgg aatcttcagc cgcaatggtg atggagatgc     3960



aacagagtat ctgccaggca gctgcccaga ttcagtcaga gttattccct tcaactgctt     4020



cagcaaatgg aaaccttcag caatcgccag tttaccagca gacttctcac atgatgagtg     4080



cattgtctac caatgaggat atgcaaatgc agtgtgaatt gttttcttct cctcctgcag     4140



tttctggaaa tgaaacttct acaactacca cacagcaggt tgcaacccct ggcactacca     4200



tgtttcagac atcaagttca ggagatggag aagaaactgg aacacaagca aaacagattc     4260



agaacagtgt ctttcagacc atggtccaaa tgcaacatag tggggacaat caacctcaag     4320



ttaacctttt ttcatccaca aaaagtatga tgagtgttca gaatagtggt acccaacaac     4380



aaggtaatgg tttattccag caagggaatg agatgatgtc acttcaatct ggaaattttt     4440



tgcagcagtc ttctcattca caggcccaac tttttcatcc tcaaaatcct attgccgatg     4500



ctcagaacct ttcccaggaa actcaaggtt ctctctttca tagtccaaat cctattgtcc     4560



acagtcagac ttctacaacc tcctctgaac aaatgcagcc tccaatgttt cactctcaaa     4620



gtaccattgc tgtgttacag ggctcttcag ttcctcaaga ccagcagtca accaacatat     4680



ttctttccca gagtcccatg aataatcttc agactaacac agtagcccaa gaagcatttt     4740



ttgcagcacc gaactcaatt tctccacttc agtcaacatc aaacagtgaa caacaagctg     4800



ctttccaaca gcaagctcca atatcacaca tccagactcc tatgctttcc caagaacagg     4860



cacaaccccc gcagcagggt ttatttcagc ctcaggtggc cctgggctcc cttccaccta     4920



atccaatgcc tcaaagccaa caaggaacca tgttccagtc acagcactca atagttgcca     4980



tgcagagtaa ctctccatcc caggaacagc agcagcagca gcaacagcag cagcaacagc     5040



agcagcaaca acaacagagc attttattca gtaatcagaa taccatggct acaatggcgt     5100



ctccaaagca accaccacca aacatgatat tcaacccaaa tcaaaatcca atggctaatc     5160



aggagcaaca gaaccagtca atttttcacc aacaaagtaa catggcccca atgaatcaag     5220



agcaacagcc catgcaattt cagagtcagt ccacagtttc ctcacttcag aacccaggtc     5280



ctacccagtc ggaatcatca cagaccccct tgttccatag ctctcctcag attcagttgg     5340



tacaagggtc acctagttct caagagcagc aagtaactct cttcttatct ccagcatcca     5400



tgtctgcctt gcagaccagt ataaatcaac aagatatgca acagtctcct ctttattccc     5460



ctcagaacaa catgcctgga attcaaggag ccacatcttc gcctcaacca caggctactt     5520



tatttcacaa cacagcagga ggcacaatga accaactgca gaattctcct ggctcatctc     5580



agcagacatc aggaatgttc ttatttggca ttcaaaataa ctgtagtcag cttttaacct     5640



ctggaccagc tacattgcct gatcagttga tggccataag tcagccaggc caaccacaaa     5700



acgagggcca gccacctgtg acaacacttc tttctcagca aatgccagag aattctccac     5760



tggcatcctc tataaacacc aaccagaaca tcgaaaagat tgatttgctt gtttcattgc     5820



aaaaccaagg gaacaacttg actggctcct tttaactgga tataaattcc acgaagaaaa     5880



tcctgattcc aagatgtcct gagatcttgt ggttccatga gaattattac tttaaaaaca     5940



aaacaaaata taaaaaactg tgtttgagta aactgataga ttttactctg actgcaaaag     6000



agcacaccta tgctgcttgt tgcagtaact aaccaccaat gttaacatct tcatatttta     6060



tattcctaat aacagtgatg actgagaatc tatttgagtt tccagctggc agaattaatt     6120



gttattattt tcctaggcgc aatttcctta aacgtacagt ttaaattcaa ggctggacca     6180



ctcagttatt attgctatta gaaaataata tatcatgttt acttttgttc ttcattattt     6240



tctttcctgc attgttttag tcaagtaatg gcttttgaaa aagtaaagtt caataataac     6300



taaggctgtg atttttttca atataaaagg cacagctgtt ggccaaagtg aaggaatctt     6360



ttttcagttt tattggagaa actgaagggt aacattctaa caagtaaact gtatgtgcag     6420



ataaaagtac tcttgattta acacaaaggc agatgataca cttataaaac tgggaacagc     6480



tggaatgctt cttgatttta ttttttcaga gagttgttag ttctctgggt ttctactaag     6540



gggtttagcc ataactgtgc atagaaaaat aattatctgt aaaaaatgaa ggggataata     6600



tatgataaat tatgttctga tatcctccta cagtagttta aattgacaga aaaatttgaa     6660



tgttttcttc ttaacccagt cttaggctgg tattcccttt ttatatatat ctatattact     6720



tttcacctct ttttcacttt actttagaga actattaata tactactggc ttcatgaccc     6780



tgtagcatct ttggccactt taatctaggg tgacctagca atcctgcagc acagggcaga     6840



gagtactgtc ttaggaatta ttaggagttg attcctgaga aacaacacat ttttccccat     6900



gaacggtgct gttctgaagt cttcaaattt ttccctctaa taggaaacag tataaatttt     6960



aattaaaaaa aaaaggcaaa ctaaaatttc ttgaaatatc acttctccct gatctgcagt     7020



gagtataaat tcacttgtca cctcagtgct ttacagtttg aagtggtcac ttacctgatg     7080



gttcccacaa gccttaggct ttacagggtt gtatcattga cttaaaatga agaattaact     7140



tgtgttacat ctataaagag caaaataaca cactccagaa cttggcagtt gtagcattag     7200



ttatacagtt ttgggtgttc ttgccacccg tgggatgcct gcttctcact accacctgtg     7260



tctggacaca tgcttatgtc tcattttcct tttggcatgt ggaaagctgt caatgcagtg     7320



taaggccaac gtgtgtgtgg cttctatgtg ttgagataat gttttggtat ccttgtccgt     7380



ttcatttatt ttttaagtgt acaaaaaata acctgttaat tgttgaaggc tacttttctg     7440



ttcttttttt tttttttttt ctatcctgta catttagttg aactgtgcgg aattgtggtg     7500



ttggttttgt ttacacagcc agatttttcc ttctttttgt tttgtgatga tcttcctttg     7560



ttctttgaat gtgctctttt gtctttttct cttttttctc atgttttctt ccctccacct     7620



ccaccccttt ctttctttct ctctctgatt gagaggcatt gaattacgtt ttcagtagta     7680



caggcttctt gccgatatga agggaacttt tcagaaagag acctactctg ggtcatttaa     7740



ttttgaatac agttttcaat cgttcaagtt ttggatggtt tatatctaat gtgtgtttca     7800



tttttttgga aagctatatt ttgtatttag gaaatggtat actattttgc tatttgtact     7860



gagtgagtac attggcataa atatagaaat ttatatatat acatatatat aaactattct     7920



tttttgccac acatttttgt ggtaaatttg tgagtttgtc tgatgttcta ccacaacgtg     7980



gcgtctgata acagtgaggg ggggtggggt ttgttatgtc tttattgagt atttaagtat     8040



cttttgaaac aaatgacctg ttcatctgtg gccattccat caggcagtta gttccttgat     8100



gtcagtagtg ggctaaaggc agcttactgt gtgtttgctg gagctttcac tcagccaagt     8160



gttagagtca ggaaacccat tgaggcaatg gcgtcaaatg gtgtttcaca agaatgagcc     8220



attcagtctt tgctcactat atatttaata ttttattatt gttgttattg ttattattaa     8280



ttggctttct gtattctatg ccttttattt ataaagacac taagaaaacc catgtttgta     8340



attttaataa catttttccc atcttgtaat atccagagct actttataaa ttctctgaac     8400



caaaagtatt ttcctcagtg tatctcttct cccccagccc ctattgggaa aaattaccca     8460



gtatagttca ggttatgagg aggatcagcc acacaatcca gtgcttcagt ttgaaaatgt     8520



aaaattctaa ccctaaagta gggttggttg aaatttcaga caaagcaaac ccagcaggta     8580



taaaaagtag tataaataca aatctgtaag ttatttttga attttctgaa cttttttcta     8640



agagattaca taggagacta aagaaatcta tctgttcaag ttctaattag gatgattgtt     8700



aatactgcac tgtggatgaa gtggcgactg gcttgtgtgc tgacttctgt ggtttagcaa     8760



gaggtttatt gttatcaaat gctaattggc aatgccaagt cactgggacc aattttctgt     8820



tttataatat ctaagtttag aacagaatat atacctgaac tgtagtggtt tgatcggatg     8880



gagacagaaa acccgatttt tattctcata aattttgtgg ttatttatac aagggctgtg     8940



ctatgctacc atattcttgt tcaataataa taggtttgtt gtttttttta cattgttaaa     9000



tgttccttac ccctaaaggt caatgttaag tacaacattc tgaaaataca atttggctac     9060



gaagagtatt catcttcttt gaagctcagt ggttgatatt tgtgctaata atgcaatttc     9120



ctgattactg ttacaagtta tagctacata tgggagagac tcagtgagcc agcaaaggcc     9180



atagaaacaa caatttatta aatgtattta tggcagaagg acctaaataa actgtgagcc     9240



accttttctt ctttatattg ttacatttaa gtgttcttgc tttcagcaac tcacattaat     9300



gcttggagct tatctctttc tctctctctc tctctctctc tgtgtgtgtg tgtgtatgtg     9360



tgtgtgtgtg tgtgtgtgtt tccttattgt cattccatta tatatccaca ccaacatggg     9420



tgacgataat tcaaagtcat attttgcctc taagcttgat catgttacct ttatgattaa     9480



agtatcatgt tatttagcca atgcaaatct gttttaaaac aaatagttta aaaaaagaac     9540



aagtttttaa gggctttatt atagaagaag tattaatgaa ggactttcct tcctccctcc     9600



ctttcctccc ctccctgcct cccttcttcc cttccatctc cccctcctcc ctgccttctt     9660



tgtttctcct tcccttattc ctccctccct cctttctccc ttccttcctt tcttccattc     9720



atccttcctt gccttttatt tttatttttt gtaatatcac atgtgctgta gtttggaatt     9780



ttattctagt gcatttcttg ctcatcagaa cctcagctaa tctacctagg aaaaatagta     9840



tcaaaggaaa tgagaaagtt gtatctgagt ccctccagaa ctaagataat tctttttgac     9900



catttaagcc tttataaatg cgttttgacc atttaagcct ttataaatgc ttgttttagg     9960



aaagtgaatc tgttagatgc atcaacaaat aatgaccagg acaaaacgat ttaataatta    10020



aagtctcaaa tcaccatggt tatacatttt caccagaaat agtaatctta caatttttca    10080



tttttctgat gaagatttct gttccaatat ctgtttccta atagattttt taaattaatt    10140



agctttcctc tgctttatga ccacaggttt tatccctaac cgagacagct gtcttatatc    10200



tgcatgcctt agactgtgtg gagggactcc atgaagaaag accataggtt agaaaaataa    10260



ctcatagtat ataccctagt aagtgggtta gtagaatctc ataacatgta ttaaaaagag    10320



gttttcttct ctgcttgttt gtgtcactag agcaaaattg tagagataat gctcataatg    10380



cagtaaatat cagaataata tctacaatat catttgtgga tggtcccagg tcccagtgct    10440



ctagttactt tacttctttt tttttttttg agatggagtc ttgctctgtc tctcaggcta    10500



gagcagtgtg cgatctcagc tcactgcagc ctccacctcc caggttcaag cgattctcct    10560



gcctcagcct cccaagtagc caggattaca ggcaccctcc actaggcccg gctaattttt    10620



tttgtatttt tttagtagag atggggtttt gccatgttgg ccaggctggt ttcgaactcc    10680



taacctccag tgatccacct gcctcggcgt cccaaagtgc taggattaca ggcatgagcc    10740



accacatccg gcctaattac ttctttaatc cccatttatt tttatgccat tctagcctca    10800



tttattaata aaattatgtt tttactttct ctttcaggaa attttttaaa ttaatatttt    10860



atatctagat ctaatgctat ggaaaagtgc ctttttatca tttataattt catttttcac    10920



tatttccaaa aacacataaa caaatagttt cagtaggtcc cagcttttac tttttccatt    10980



taaaccttct tttctccatt tcttcccttt ggcttaagaa taaaagaaaa ggtacattgc    11040



tagaattgtt tctttgggag agggtaaaag attacagaat tagactgttc agcctttata    11100



taaactaaat ttgtcttcat ctcaaccagc taatggtagg tcttatctga atactcatga    11160



gaattttagc atctgtgaaa ctccatgcac cagatgtgtg taaatttcag gaagaaagtg    11220



ttgaaagcat tttctctgat gttaattaga tggaaataaa tcactaaaac atagtttagg    11280



taaagcctga ttatgccact tttttttaac tagacagggc aaagttgttt atgttagtgt    11340



acttcttgtc tatcctcagt taatttacct agacaaaaag tgtcaaagga aatgagaaaa    11400



aggttatatc tgactccctc cagacctaag ataattcctt ttgatcagat acagtcagat    11460



ggagtgcctt ggtttttgtt aattttgcct ctattccagc tccttaccac agcggtggtg    11520



cttaaagaaa ggatcatcag caacaggtca ggatagttct acctttggga tagggctgct    11580



ttccccgtgc tagtatttct gtgactgtta gtggcactga ggactgcaaa cttttatgca    11640



atattcttaa taccctattg atattatgca ctttaatcat tccaaagaag ccaagaatgc    11700



tgtatagtga tgattccttc ctaatgaatt catcttaact atttagaatg ttatgtccct    11760



tttcttttgg atagccaact tggtataaat gttatatgga tttttctaaa atgactatat    11820



aggacttaag actttgaaat gtaatttact tataagggga aataattatg ctttagcaca    11880



tcattttaga aacgtcacat tttagaaaca ttcagcttgc taacctacat gtttgggaat    11940



tcattaaaac cagttgtcta tatattttgt gccatgtata taagaacatt acaatatatc    12000



tttttctaca tatgtagtat gtgcaaccag tggttctcag agtatggttc tcagcccacc    12060



agctagtatc agtatcacct gggaactagt tagaaatgta aattctttgg ccccatccca    12120



gacatactga gtcagaaact ctggaatagg gcccccgcaa tctgttttca caagccctcc    12180



aggtgattct gatgcacact ttaaagttta ggaaccactg ggctaagact ctgttgagat    12240



atagagtttt tcttccactc agactgatat agttatacat tgttcttcat gtaaattcag    12300



cttaacctgg ttatctataa tcttttattg gcaaaagtta attctcagta ctgcctatag    12360



agatacagtg tattttatgt acatacacaa ttagtctaat tcttgataat tcagttaatt    12420



tagtttggca ttttcctacc acttactaaa aggtttacat taaatgactg atttaaatat    12480



ataggtgcaa tgttctatgt ttattttaat tgttatgaca tttaagtagc taatataatt    12540



gaccggtgct aaagtctcct gtttatccat aaaatgggta cattatgggc agtgtaatac    12600



aagctttctt ttcattgcct agtactttac cagcagacca cagttttgcc ctggctagac    12660



caaccctcag aacaaaatca tcattccttg tatttatatt tgtatctgag atagtaaaca    12720



agatggctgg ccaggtcaac atggcacctt aacttatttt tttaataggt aaaacttctt    12780



caaaagtagc ttgctttgta taagaactaa gctatcagta tagatatagc tatccttgga    12840



gcttatgttt cagacaagaa ttatttacta aaataaataa taaacaagat aatgcattat    12900



acaatttggg catttctcgt ttctcaagtg tatgcatcat ggtaaatata aactaaccac    12960



aagataggta gattgattca tttcatttta atctccttgt gtaattcagt acctccataa    13020



ttgttctaat cttcttccca ctgtttacaa attaccagtt aattaactcg tgaaagaaaa    13080



attcacatat cagaataaaa ataaatgtat actcacttta taaaaatcac cactgctgtc    13140



tttccttaat actagcagtg gaaatgtaag tggcttactc tacaaatttt ggtgctggca    13200



aatacatagg caaactgttg ggagctgctc tagttacatt cctcccttct tattcccttt    13260



ttctcttcct cactttattg cataacatat tcctgtaccc aaagcattct accacagttc    13320



tatttgactc ccacttgtaa taactccttt aaaaaattcc atgtttaacc atatgaccct    13380



gcttgcttac tcatattctc cctccctctc cccttccttt ctctctcttc cagaagtcat    13440



ttgcctggtt tgaaatattt tgtagggatt gcttattata ttattttagc tgatgaacct    13500



caggacaacg tctacacaca cacacataca tacacgcaca caaaatctca gctgttgaag    13560



agtgggcttg gaatcagact tctgtgtcca gtaaaaaact cctgcactga agtcattgtg    13620



acttgagtag ttacagactg attccagtga acttgatcta atttcttttg atctaatgaa    13680



tgtgtctgct taccttgttt ccttttaatt gataagctcc aagtagttgc taattttttg    13740



acaactttaa atgagtttca ttcacttctt ttacttaatg ttttaagtat agtaccaata    13800



atttcattaa cctgttctca agtggtttag ctaccattct gccattttta atttttattt    13860



aattttattt gcttgagcac actgatcaac cactgaactg ccttcttcca ttgtcctgca    13920



atgatataag ggttacattt ttgtgtatat ggctttcata gttgggattt cagagcactg    13980



ataccagata ttttcagttt gttctctggg ggaatttcat ttgcatctat gtttttagct    14040



atctgtgata acttgttaaa tattaaaaag atattttgct tctattggaa catttgtata    14100



ctcgcaacta tatttctgta aacagctgca gtcaaaaata aaacactgaa agttaaaaaa    14160



aaaaaaaaaa aaaa                                                      14174





<210>  110

<211>  1548

<212>  PRT

<213>  Homo sapiens



<400>  110



Met Pro Ser Asp Phe Ile Ser Leu Leu Ser Ala Asp Leu Asp Leu Glu 

1               5                   10                  15      





Ser Pro Lys Ser Leu Tyr Ser Arg Asp Ser Leu Lys Leu His Pro Ser 

            20                  25                  30          





Gln Asn Phe His Arg Ala Gly Leu Leu Glu Glu Ser Val Tyr Asp Leu 

        35                  40                  45              





Leu Pro Lys Glu Leu Gln Leu Pro Pro Ser Arg Glu Thr Ser Val Ala 

    50                  55                  60                  





Ser Met Ser Gln Thr Ser Gly Gly Glu Ala Gly Ser Pro Pro Pro Ala 

65                  70                  75                  80  





Val Val Ala Ala Asp Ala Ser Ser Ala Pro Ser Ser Ser Ser Met Gly 

                85                  90                  95      





Gly Ala Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile Tyr Ser 

            100                 105                 110         





Thr Ser Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys Ser Ser 

        115                 120                 125             





Ala Val Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu Thr Ser 

    130                 135                 140                 





Asn Thr Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr Val Leu 

145                 150                 155                 160 





Tyr Ile Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg Met Ser 

                165                 170                 175     





Cys Gln Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys Ser Met 

            180                 185                 190         





Trp Met Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr Ser Ser 

        195                 200                 205             





Tyr Asn Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg Asn Pro 

    210                 215                 220                 





Lys Gln Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser Asn Met 

225                 230                 235                 240 





Asp Ile Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val Leu Ser 

                245                 250                 255     





Gln Leu Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn Gly Thr 

            260                 265                 270         





Leu Glu Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met Leu Cys 

        275                 280                 285             





Gly Gln Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile Val Val 

    290                 295                 300                 





Gln Pro Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly Ser Arg 

305                 310                 315                 320 





Gly Ser Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val Lys Leu 

                325                 330                 335     





Glu Gly His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly Asn Asp 

            340                 345                 350         





Ser Gly Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg Val Thr 

        355                 360                 365             





Gly Arg Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly Thr Thr 

    370                 375                 380                 





Val Ile Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu Ala Val 

385                 390                 395                 400 





Asp Cys Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu Ala Arg 

                405                 410                 415     





Ile Gly Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg Leu Val 

            420                 425                 430         





Phe Arg Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr Leu Gln 

        435                 440                 445             





Thr Pro Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val Pro Glu 

    450                 455                 460                 





Ile Leu Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu Glu Glu 

465                 470                 475                 480 





Val Phe Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val Ile Phe 

                485                 490                 495     





Gln Glu Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala Glu Ile 

            500                 505                 510         





Asp Met Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val Pro Pro 

        515                 520                 525             





Tyr His Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile Tyr Val 

    530                 535                 540                 





Val Thr Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr Tyr Thr 

545                 550                 555                 560 





Pro Asp Pro Ala Ala Gly Ala Leu Asn Val Asn Val Lys Lys Glu Ile 

                565                 570                 575     





Ser Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met Lys Ala Met 

            580                 585                 590         





Lys Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile Pro Asn Ala 

        595                 600                 605             





Leu Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser Glu Asp Val 

    610                 615                 620                 





Thr Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr Ile Phe Lys 

625                 630                 635                 640 





Thr Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu Asn Ile Ser 

                645                 650                 655     





Asn Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser Ser His Leu 

            660                 665                 670         





Pro Ser Glu Asn Glu Lys Gln Gln Gln Ile Gln Pro Lys Ala Tyr Asn 

        675                 680                 685             





Pro Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser Gln Pro Gly 

    690                 695                 700                 





Thr Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn Ser Asp Ala 

705                 710                 715                 720 





Leu Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr Gln Ser Arg 

                725                 730                 735     





Glu Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser Gln Leu Thr 

            740                 745                 750         





Glu Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu Gln Ala Gln 

        755                 760                 765             





Thr Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser Pro Asn Ser 

    770                 775                 780                 





Val Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala Gly Ser Phe 

785                 790                 795                 800 





Thr Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp Leu Val Gln 

                805                 810                 815     





Gln Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu Phe Ser Ala 

            820                 825                 830         





Pro Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala Asp Ile Phe 

        835                 840                 845             





Gln Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly Met Phe Ser 

    850                 855                 860                 





Ser Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu Leu Pro Gly 

865                 870                 875                 880 





Arg Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu Ser Asn Gln 

                885                 890                 895     





Gln Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser Ser Ala Ala 

            900                 905                 910         





Met Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala Ala Gln Ile 

        915                 920                 925             





Gln Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly Asn Leu Gln 

    930                 935                 940                 





Gln Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser Ala Leu Ser 

945                 950                 955                 960 





Thr Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser Ser Pro Pro 

                965                 970                 975     





Ala Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln Gln Val Ala 

            980                 985                 990         





Thr Pro Gly Thr Thr Met Phe Gln  Thr Ser Ser Ser Gly  Asp Gly Glu 

        995                 1000                 1005             





Glu Thr  Gly Thr Gln Ala Lys  Gln Ile Gln Asn Ser  Val Phe Gln 

    1010                 1015                 1020             





Thr Met  Val Gln Met Gln His  Ser Gly Asp Asn Gln  Pro Gln Val 

    1025                 1030                 1035             





Asn Leu  Phe Ser Ser Thr Lys  Ser Met Met Ser Val  Gln Asn Ser 

    1040                 1045                 1050             





Gly Thr  Gln Gln Gln Gly Asn  Gly Leu Phe Gln Gln  Gly Asn Glu 

    1055                 1060                 1065             





Met Met  Ser Leu Gln Ser Gly  Asn Phe Leu Gln Gln  Ser Ser His 

    1070                 1075                 1080             





Ser Gln  Ala Gln Leu Phe His  Pro Gln Asn Pro Ile  Ala Asp Ala 

    1085                 1090                 1095             





Gln Asn  Leu Ser Gln Glu Thr  Gln Gly Ser Leu Phe  His Ser Pro 

    1100                 1105                 1110             





Asn Pro  Ile Val His Ser Gln  Thr Ser Thr Thr Ser  Ser Glu Gln 

    1115                 1120                 1125             





Met Gln  Pro Pro Met Phe His  Ser Gln Ser Thr Ile  Ala Val Leu 

    1130                 1135                 1140             





Gln Gly  Ser Ser Val Pro Gln  Asp Gln Gln Ser Thr  Asn Ile Phe 

    1145                 1150                 1155             





Leu Ser  Gln Ser Pro Met Asn  Asn Leu Gln Thr Asn  Thr Val Ala 

    1160                 1165                 1170             





Gln Glu  Ala Phe Phe Ala Ala  Pro Asn Ser Ile Ser  Pro Leu Gln 

    1175                 1180                 1185             





Ser Thr  Ser Asn Ser Glu Gln  Gln Ala Ala Phe Gln  Gln Gln Ala 

    1190                 1195                 1200             





Pro Ile  Ser His Ile Gln Thr  Pro Met Leu Ser Gln  Glu Gln Ala 

    1205                 1210                 1215             





Gln Pro  Pro Gln Gln Gly Leu  Phe Gln Pro Gln Val  Ala Leu Gly 

    1220                 1225                 1230             





Ser Leu  Pro Pro Asn Pro Met  Pro Gln Ser Gln Gln  Gly Thr Met 

    1235                 1240                 1245             





Phe Gln  Ser Gln His Ser Ile  Val Ala Met Gln Ser  Asn Ser Pro 

    1250                 1255                 1260             





Ser Gln  Glu Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 

    1265                 1270                 1275             





Gln Gln  Gln Gln Gln Ser Ile  Leu Phe Ser Asn Gln  Asn Thr Met 

    1280                 1285                 1290             





Ala Thr  Met Ala Ser Pro Lys  Gln Pro Pro Pro Asn  Met Ile Phe 

    1295                 1300                 1305             





Asn Pro  Asn Gln Asn Pro Met  Ala Asn Gln Glu Gln  Gln Asn Gln 

    1310                 1315                 1320             





Ser Ile  Phe His Gln Gln Ser  Asn Met Ala Pro Met  Asn Gln Glu 

    1325                 1330                 1335             





Gln Gln  Pro Met Gln Phe Gln  Ser Gln Ser Thr Val  Ser Ser Leu 

    1340                 1345                 1350             





Gln Asn  Pro Gly Pro Thr Gln  Ser Glu Ser Ser Gln  Thr Pro Leu 

    1355                 1360                 1365             





Phe His  Ser Ser Pro Gln Ile  Gln Leu Val Gln Gly  Ser Pro Ser 

    1370                 1375                 1380             





Ser Gln  Glu Gln Gln Val Thr  Leu Phe Leu Ser Pro  Ala Ser Met 

    1385                 1390                 1395             





Ser Ala  Leu Gln Thr Ser Ile  Asn Gln Gln Asp Met  Gln Gln Ser 

    1400                 1405                 1410             





Pro Leu  Tyr Ser Pro Gln Asn  Asn Met Pro Gly Ile  Gln Gly Ala 

    1415                 1420                 1425             





Thr Ser  Ser Pro Gln Pro Gln  Ala Thr Leu Phe His  Asn Thr Ala 

    1430                 1435                 1440             





Gly Gly  Thr Met Asn Gln Leu  Gln Asn Ser Pro Gly  Ser Ser Gln 

    1445                 1450                 1455             





Gln Thr  Ser Gly Met Phe Leu  Phe Gly Ile Gln Asn  Asn Cys Ser 

    1460                 1465                 1470             





Gln Leu  Leu Thr Ser Gly Pro  Ala Thr Leu Pro Asp  Gln Leu Met 

    1475                 1480                 1485             





Ala Ile  Ser Gln Pro Gly Gln  Pro Gln Asn Glu Gly  Gln Pro Pro 

    1490                 1495                 1500             





Val Thr  Thr Leu Leu Ser Gln  Gln Met Pro Glu Asn  Ser Pro Leu 

    1505                 1510                 1515             





Ala Ser  Ser Ile Asn Thr Asn  Gln Asn Ile Glu Lys  Ile Asp Leu 

    1520                 1525                 1530             





Leu Val  Ser Leu Gln Asn Gln  Gly Asn Asn Leu Thr  Gly Ser Phe 

    1535                 1540                 1545             





<210>  111

<211>  14123

<212>  DNA

<213>  Homo sapiens



<400>  111

tgcaacggaa acttttggct ccacgaacag aaaagcaaga gcaaaaactc agttaaatgc       60



gttcttcctc catctttgcc tagtccaaaa ggaaaaaaaa agaaacagaa aaaagaaaaa      120



ctgtttggaa gagtagcgtt gaggtttgct ttttacctgt ttttcctcta gaacagccag      180



gtggattcac atgatccaat tttttaattg tcttctatgt cccactccga ataacccgga      240



tgccccagca caatcagaga gatcgttttt tttaaaaaaa atttcagcct ccaaaggtag      300



gaggggagtg ttaggggaga aagtacttta attaaaaatc aataactcga ggtttttggg      360



atacggtttg ccatttccta attaagaaat gggtttgaca gtccctttgt acacactgct      420



atgcaaaccc caaagggttg gcggctgtcc gggcgatgac actccggtcc cctgcgagac      480



cccgggccag ccaggcccgt ccgccgccgg cctctggggt ccgtccccgg ctcgcgcaga      540



cctctcgctt ctctcggctc tgtctcctgc gctcagctct gctcggggcc ggccgcctca      600



ggctcgccgc caccaggtcg ttgcaaatac cttttccctc cccggggccc cagcgcgcgg      660



ccacctccca gcctcccccc ctcccaccct ggcagcgggg ccctttcccg gctcaggaac      720



agcagcagcc cgggccgcgc cggcaggaag cgaggcccat gttgctgctg ttccctggcg      780



cgcctccccg ccctccgggg gccgccacgg ctcttccgcg ctcccgggca cccccctccg      840



cgcctgcgct gtgccccacg ggggcggggc tcagattcct gtcagcggcg gcggcggtgg      900



cggcgaccgt cagttttcgc tgaggagaaa cacgaaacgg accctttggc tctccccctt      960



ccccttcccc gtcctgaacc cctctcctgg tcaccgagaa tcagtccccg tggagttccc     1020



cctccacctc gccatcgttt cctcggtcct cggcccagtg gaagtcacta ccctcgagga     1080



ggaggcagcg gcagccgccc tcgcgtcgcc gcccccggtt cggtgcccgc ggtcccggag     1140



aggaggtgcc gccgccaccg ccgctccccc cctcccgctg ccctcgggcc gggctgggtc     1200



gagctgcgat gccctcggac ttcatctcat tgctcagcgc ggacctagac ctggaatcgc     1260



ccaagtccct ctactcgcga gaatctgtct atgatcttct cccaaaggag ttacagttac     1320



ctccatctag agaaacatct gtagcatcaa tgagtcagac aagcggtggt gaggcaggct     1380



cgcctcctcc agctgttgtt gctgctgatg cttcttcagc tccctcctct tcctccatgg     1440



gcggtgcttg cagctccttt accacctctt ccagccctac catttattct acctcagtca     1500



ccgacagcaa ggctatgcaa gtggagagct gctcctcagc cgtgggggta agtaacagag     1560



gggtaagtga aaagcagtta accagtaaca cagttcagca gcatccatca acaccgaaga     1620



ggcacacagt cttgtacatc tcaccaccac ctgaggactt gctggataac agtcggatgt     1680



cctgccagga tgaggggtgt ggattggaat ctgagcagag ctgcagtatg tggatggagg     1740



attccccctc caacttcagt aacatgagca ccagttccta caatgataac actgaggtac     1800



ctcgtaaatc acgaaaacga aatccaaagc agaggccggg ggtcaaacga cgagattgtg     1860



aagaatctaa tatggatata tttgatgccg acagtgccaa agcacctcac tatgtgcttt     1920



ctcagcttac cacggacaac aaaggcaact caaaagcggg aaatggaaca ttggaaaacc     1980



aaaaaggaac tggagtaaag aagagcccta tgttgtgtgg acaatatcct gttaaaagtg     2040



agggaaagga gctgaagata gttgtacaac ctgagacaca gcaccgagct cggtacctga     2100



ctgagggcag ccgtggctca gtgaaagata gaacacagca aggctttcct acagtaaagc     2160



tggaaggcca taatgaacct gtagtgttgc aagtgtttgt gggcaacgac tctggacgag     2220



tgaaaccaca tggattttat caggcctgca gagtaactgg acgaaataca actccttgca     2280



aagaagtgga cattgaaggc actactgtta tagaagtcgg ccttgatcct agcaacaaca     2340



tgacactggc ggtggactgc gtagggatat tgaaattgag gaatgctgat gtcgaagcca     2400



gaataggaat tgctggttcc aagaagaaaa gcactcgtgc cagattggtt tttcgagtta     2460



atatcatgag gaaagatggc tccactttga cactgcaaac accctcttct ccaattttgt     2520



gtactcagcc agcaggagtg ccagaaatct taaagaaaag cttgcatagc tgttcagtga     2580



aaggagaaga agaagtgttt ttaatcggca agaactttct gaaaggaact aaagttattt     2640



tccaagaaaa tgtttctgat gaaaactctt ggaagtcaga agctgaaatt gatatggaac     2700



tatttcatca gaatcatctt attgtgaagg ttcctcccta tcatgaccaa catataactt     2760



tgcctgtgtc agtgggaata tatgtagtga caaatgctgg aagatctcat gatgttcaac     2820



cattcactta cactccagac ccagcagcag ctggtgcttt gaatgtaaat gtgaagaagg     2880



aaatatctag tccagcaaga ccttgctctt ttgaagaggc catgaaagca atgaaaacta     2940



ctggatgtaa tttagataag gtaaatatta tccctaatgc cctgatgact ccactcatac     3000



caagcagtat gattaagagt gaagatgtta ctccaatgga agtaacagca gaaaaaagat     3060



cttccactat ttttaagact acaaagtctg ttggatcaac tcagcaaaca ttagaaaaca     3120



tctcaaacat agcaggaaat ggctcttttt catcaccatc atcttcccac ctaccttctg     3180



aaaatgaaaa acagcagcag attcagccca aggcatacaa cccagagacc ctgacaacta     3240



ttcaaaccca ggacatctca cagcctggta cttttccagc agtttctgct tctagtcagc     3300



tgcccaacag cgatgcacta ttgcagcagg ctacacagtt tcagacaaga gaaactcagt     3360



ctagagagat attacagtca gatggtacag tggttaattt gtcacaactg actgaggcat     3420



cacaacaaca gcagcagtca ccactacaag aacaagcaca gactttacag cagcagattt     3480



catcaaatat ttttccatca ccaaatagtg tgagtcagct tcagaatact attcagcagc     3540



tgcaagcagg gagtttcaca ggcagtactg ctagtggcag cagtggaagt gttgacttgg     3600



tccaacaagt tttagaggca cagcagcagt tatcttcagt tttattttct gctccagatg     3660



gtaatgagaa tgttcaagag cagcttagtg cagatatttt tcaacaagtc agtcaaattc     3720



agagtggtgt aagccctgga atgttttcct caacagagcc aacagtccat accagaccag     3780



ataatttatt acctggaaga gctgaaagtg ttcatccaca gtctgaaaac acgttatcta     3840



atcaacagca gcagcagcag cagcaacagc aagtgatgga atcttcagcc gcaatggtga     3900



tggagatgca acagagtatc tgccaggcag ctgcccagat tcagtcagag ttattccctt     3960



caactgcttc agcaaatgga aaccttcagc aatcgccagt ttaccagcag acttctcaca     4020



tgatgagtgc attgtctacc aatgaggata tgcaaatgca gtgtgaattg ttttcttctc     4080



ctcctgcagt ttctggaaat gaaacttcta caactaccac acagcaggtt gcaacccctg     4140



gcactaccat gtttcagaca tcaagttcag gagatggaga agaaactgga acacaagcaa     4200



aacagattca gaacagtgtc tttcagacca tggtccaaat gcaacatagt ggggacaatc     4260



aacctcaagt taaccttttt tcatccacaa aaagtatgat gagtgttcag aatagtggta     4320



cccaacaaca aggtaatggt ttattccagc aagggaatga gatgatgtca cttcaatctg     4380



gaaatttttt gcagcagtct tctcattcac aggcccaact ttttcatcct caaaatccta     4440



ttgccgatgc tcagaacctt tcccaggaaa ctcaaggttc tctctttcat agtccaaatc     4500



ctattgtcca cagtcagact tctacaacct cctctgaaca aatgcagcct ccaatgtttc     4560



actctcaaag taccattgct gtgttacagg gctcttcagt tcctcaagac cagcagtcaa     4620



ccaacatatt tctttcccag agtcccatga ataatcttca gactaacaca gtagcccaag     4680



aagcattttt tgcagcaccg aactcaattt ctccacttca gtcaacatca aacagtgaac     4740



aacaagctgc tttccaacag caagctccaa tatcacacat ccagactcct atgctttccc     4800



aagaacaggc acaacccccg cagcagggtt tatttcagcc tcaggtggcc ctgggctccc     4860



ttccacctaa tccaatgcct caaagccaac aaggaaccat gttccagtca cagcactcaa     4920



tagttgccat gcagagtaac tctccatccc aggaacagca gcagcagcag caacagcagc     4980



agcaacagca gcagcaacaa caacagagca ttttattcag taatcagaat accatggcta     5040



caatggcgtc tccaaagcaa ccaccaccaa acatgatatt caacccaaat caaaatccaa     5100



tggctaatca ggagcaacag aaccagtcaa tttttcacca acaaagtaac atggccccaa     5160



tgaatcaaga gcaacagccc atgcaatttc agagtcagtc cacagtttcc tcacttcaga     5220



acccaggtcc tacccagtcg gaatcatcac agaccccctt gttccatagc tctcctcaga     5280



ttcagttggt acaagggtca cctagttctc aagagcagca agtaactctc ttcttatctc     5340



cagcatccat gtctgccttg cagaccagta taaatcaaca agatatgcaa cagtctcctc     5400



tttattcccc tcagaacaac atgcctggaa ttcaaggagc cacatcttcg cctcaaccac     5460



aggctacttt atttcacaac acagcaggag gcacaatgaa ccaactgcag aattctcctg     5520



gctcatctca gcagacatca ggaatgttct tatttggcat tcaaaataac tgtagtcagc     5580



ttttaacctc tggaccagct acattgcctg atcagttgat ggccataagt cagccaggcc     5640



aaccacaaaa cgagggccag ccacctgtga caacacttct ttctcagcaa atgccagaga     5700



attctccact ggcatcctct ataaacacca accagaacat cgaaaagatt gatttgcttg     5760



tttcattgca aaaccaaggg aacaacttga ctggctcctt ttaactggat ataaattcca     5820



cgaagaaaat cctgattcca agatgtcctg agatcttgtg gttccatgag aattattact     5880



ttaaaaacaa aacaaaatat aaaaaactgt gtttgagtaa actgatagat tttactctga     5940



ctgcaaaaga gcacacctat gctgcttgtt gcagtaacta accaccaatg ttaacatctt     6000



catattttat attcctaata acagtgatga ctgagaatct atttgagttt ccagctggca     6060



gaattaattg ttattatttt cctaggcgca atttccttaa acgtacagtt taaattcaag     6120



gctggaccac tcagttatta ttgctattag aaaataatat atcatgttta cttttgttct     6180



tcattatttt ctttcctgca ttgttttagt caagtaatgg cttttgaaaa agtaaagttc     6240



aataataact aaggctgtga tttttttcaa tataaaaggc acagctgttg gccaaagtga     6300



aggaatcttt tttcagtttt attggagaaa ctgaagggta acattctaac aagtaaactg     6360



tatgtgcaga taaaagtact cttgatttaa cacaaaggca gatgatacac ttataaaact     6420



gggaacagct ggaatgcttc ttgattttat tttttcagag agttgttagt tctctgggtt     6480



tctactaagg ggtttagcca taactgtgca tagaaaaata attatctgta aaaaatgaag     6540



gggataatat atgataaatt atgttctgat atcctcctac agtagtttaa attgacagaa     6600



aaatttgaat gttttcttct taacccagtc ttaggctggt attccctttt tatatatatc     6660



tatattactt ttcacctctt tttcacttta ctttagagaa ctattaatat actactggct     6720



tcatgaccct gtagcatctt tggccacttt aatctagggt gacctagcaa tcctgcagca     6780



cagggcagag agtactgtct taggaattat taggagttga ttcctgagaa acaacacatt     6840



tttccccatg aacggtgctg ttctgaagtc ttcaaatttt tccctctaat aggaaacagt     6900



ataaatttta attaaaaaaa aaaggcaaac taaaatttct tgaaatatca cttctccctg     6960



atctgcagtg agtataaatt cacttgtcac ctcagtgctt tacagtttga agtggtcact     7020



tacctgatgg ttcccacaag ccttaggctt tacagggttg tatcattgac ttaaaatgaa     7080



gaattaactt gtgttacatc tataaagagc aaaataacac actccagaac ttggcagttg     7140



tagcattagt tatacagttt tgggtgttct tgccacccgt gggatgcctg cttctcacta     7200



ccacctgtgt ctggacacat gcttatgtct cattttcctt ttggcatgtg gaaagctgtc     7260



aatgcagtgt aaggccaacg tgtgtgtggc ttctatgtgt tgagataatg ttttggtatc     7320



cttgtccgtt tcatttattt tttaagtgta caaaaaataa cctgttaatt gttgaaggct     7380



acttttctgt tctttttttt tttttttttc tatcctgtac atttagttga actgtgcgga     7440



attgtggtgt tggttttgtt tacacagcca gatttttcct tctttttgtt ttgtgatgat     7500



cttcctttgt tctttgaatg tgctcttttg tctttttctc ttttttctca tgttttcttc     7560



cctccacctc cacccctttc tttctttctc tctctgattg agaggcattg aattacgttt     7620



tcagtagtac aggcttcttg ccgatatgaa gggaactttt cagaaagaga cctactctgg     7680



gtcatttaat tttgaataca gttttcaatc gttcaagttt tggatggttt atatctaatg     7740



tgtgtttcat ttttttggaa agctatattt tgtatttagg aaatggtata ctattttgct     7800



atttgtactg agtgagtaca ttggcataaa tatagaaatt tatatatata catatatata     7860



aactattctt ttttgccaca catttttgtg gtaaatttgt gagtttgtct gatgttctac     7920



cacaacgtgg cgtctgataa cagtgagggg gggtggggtt tgttatgtct ttattgagta     7980



tttaagtatc ttttgaaaca aatgacctgt tcatctgtgg ccattccatc aggcagttag     8040



ttccttgatg tcagtagtgg gctaaaggca gcttactgtg tgtttgctgg agctttcact     8100



cagccaagtg ttagagtcag gaaacccatt gaggcaatgg cgtcaaatgg tgtttcacaa     8160



gaatgagcca ttcagtcttt gctcactata tatttaatat tttattattg ttgttattgt     8220



tattattaat tggctttctg tattctatgc cttttattta taaagacact aagaaaaccc     8280



atgtttgtaa ttttaataac atttttccca tcttgtaata tccagagcta ctttataaat     8340



tctctgaacc aaaagtattt tcctcagtgt atctcttctc ccccagcccc tattgggaaa     8400



aattacccag tatagttcag gttatgagga ggatcagcca cacaatccag tgcttcagtt     8460



tgaaaatgta aaattctaac cctaaagtag ggttggttga aatttcagac aaagcaaacc     8520



cagcaggtat aaaaagtagt ataaatacaa atctgtaagt tatttttgaa ttttctgaac     8580



ttttttctaa gagattacat aggagactaa agaaatctat ctgttcaagt tctaattagg     8640



atgattgtta atactgcact gtggatgaag tggcgactgg cttgtgtgct gacttctgtg     8700



gtttagcaag aggtttattg ttatcaaatg ctaattggca atgccaagtc actgggacca     8760



attttctgtt ttataatatc taagtttaga acagaatata tacctgaact gtagtggttt     8820



gatcggatgg agacagaaaa cccgattttt attctcataa attttgtggt tatttataca     8880



agggctgtgc tatgctacca tattcttgtt caataataat aggtttgttg ttttttttac     8940



attgttaaat gttccttacc cctaaaggtc aatgttaagt acaacattct gaaaatacaa     9000



tttggctacg aagagtattc atcttctttg aagctcagtg gttgatattt gtgctaataa     9060



tgcaatttcc tgattactgt tacaagttat agctacatat gggagagact cagtgagcca     9120



gcaaaggcca tagaaacaac aatttattaa atgtatttat ggcagaagga cctaaataaa     9180



ctgtgagcca ccttttcttc tttatattgt tacatttaag tgttcttgct ttcagcaact     9240



cacattaatg cttggagctt atctctttct ctctctctct ctctctctct gtgtgtgtgt     9300



gtgtatgtgt gtgtgtgtgt gtgtgtgttt ccttattgtc attccattat atatccacac     9360



caacatgggt gacgataatt caaagtcata ttttgcctct aagcttgatc atgttacctt     9420



tatgattaaa gtatcatgtt atttagccaa tgcaaatctg ttttaaaaca aatagtttaa     9480



aaaaagaaca agtttttaag ggctttatta tagaagaagt attaatgaag gactttcctt     9540



cctccctccc tttcctcccc tccctgcctc ccttcttccc ttccatctcc ccctcctccc     9600



tgccttcttt gtttctcctt cccttattcc tccctccctc ctttctccct tccttccttt     9660



cttccattca tccttccttg ccttttattt ttattttttg taatatcaca tgtgctgtag     9720



tttggaattt tattctagtg catttcttgc tcatcagaac ctcagctaat ctacctagga     9780



aaaatagtat caaaggaaat gagaaagttg tatctgagtc cctccagaac taagataatt     9840



ctttttgacc atttaagcct ttataaatgc gttttgacca tttaagcctt tataaatgct     9900



tgttttagga aagtgaatct gttagatgca tcaacaaata atgaccagga caaaacgatt     9960



taataattaa agtctcaaat caccatggtt atacattttc accagaaata gtaatcttac    10020



aatttttcat ttttctgatg aagatttctg ttccaatatc tgtttcctaa tagatttttt    10080



aaattaatta gctttcctct gctttatgac cacaggtttt atccctaacc gagacagctg    10140



tcttatatct gcatgcctta gactgtgtgg agggactcca tgaagaaaga ccataggtta    10200



gaaaaataac tcatagtata taccctagta agtgggttag tagaatctca taacatgtat    10260



taaaaagagg ttttcttctc tgcttgtttg tgtcactaga gcaaaattgt agagataatg    10320



ctcataatgc agtaaatatc agaataatat ctacaatatc atttgtggat ggtcccaggt    10380



cccagtgctc tagttacttt acttcttttt ttttttttga gatggagtct tgctctgtct    10440



ctcaggctag agcagtgtgc gatctcagct cactgcagcc tccacctccc aggttcaagc    10500



gattctcctg cctcagcctc ccaagtagcc aggattacag gcaccctcca ctaggcccgg    10560



ctaatttttt ttgtattttt ttagtagaga tggggttttg ccatgttggc caggctggtt    10620



tcgaactcct aacctccagt gatccacctg cctcggcgtc ccaaagtgct aggattacag    10680



gcatgagcca ccacatccgg cctaattact tctttaatcc ccatttattt ttatgccatt    10740



ctagcctcat ttattaataa aattatgttt ttactttctc tttcaggaaa ttttttaaat    10800



taatatttta tatctagatc taatgctatg gaaaagtgcc tttttatcat ttataatttc    10860



atttttcact atttccaaaa acacataaac aaatagtttc agtaggtccc agcttttact    10920



ttttccattt aaaccttctt ttctccattt cttccctttg gcttaagaat aaaagaaaag    10980



gtacattgct agaattgttt ctttgggaga gggtaaaaga ttacagaatt agactgttca    11040



gcctttatat aaactaaatt tgtcttcatc tcaaccagct aatggtaggt cttatctgaa    11100



tactcatgag aattttagca tctgtgaaac tccatgcacc agatgtgtgt aaatttcagg    11160



aagaaagtgt tgaaagcatt ttctctgatg ttaattagat ggaaataaat cactaaaaca    11220



tagtttaggt aaagcctgat tatgccactt ttttttaact agacagggca aagttgttta    11280



tgttagtgta cttcttgtct atcctcagtt aatttaccta gacaaaaagt gtcaaaggaa    11340



atgagaaaaa ggttatatct gactccctcc agacctaaga taattccttt tgatcagata    11400



cagtcagatg gagtgccttg gtttttgtta attttgcctc tattccagct ccttaccaca    11460



gcggtggtgc ttaaagaaag gatcatcagc aacaggtcag gatagttcta cctttgggat    11520



agggctgctt tccccgtgct agtatttctg tgactgttag tggcactgag gactgcaaac    11580



ttttatgcaa tattcttaat accctattga tattatgcac tttaatcatt ccaaagaagc    11640



caagaatgct gtatagtgat gattccttcc taatgaattc atcttaacta tttagaatgt    11700



tatgtccctt ttcttttgga tagccaactt ggtataaatg ttatatggat ttttctaaaa    11760



tgactatata ggacttaaga ctttgaaatg taatttactt ataaggggaa ataattatgc    11820



tttagcacat cattttagaa acgtcacatt ttagaaacat tcagcttgct aacctacatg    11880



tttgggaatt cattaaaacc agttgtctat atattttgtg ccatgtatat aagaacatta    11940



caatatatct ttttctacat atgtagtatg tgcaaccagt ggttctcaga gtatggttct    12000



cagcccacca gctagtatca gtatcacctg ggaactagtt agaaatgtaa attctttggc    12060



cccatcccag acatactgag tcagaaactc tggaataggg cccccgcaat ctgttttcac    12120



aagccctcca ggtgattctg atgcacactt taaagtttag gaaccactgg gctaagactc    12180



tgttgagata tagagttttt cttccactca gactgatata gttatacatt gttcttcatg    12240



taaattcagc ttaacctggt tatctataat cttttattgg caaaagttaa ttctcagtac    12300



tgcctataga gatacagtgt attttatgta catacacaat tagtctaatt cttgataatt    12360



cagttaattt agtttggcat tttcctacca cttactaaaa ggtttacatt aaatgactga    12420



tttaaatata taggtgcaat gttctatgtt tattttaatt gttatgacat ttaagtagct    12480



aatataattg accggtgcta aagtctcctg tttatccata aaatgggtac attatgggca    12540



gtgtaataca agctttcttt tcattgccta gtactttacc agcagaccac agttttgccc    12600



tggctagacc aaccctcaga acaaaatcat cattccttgt atttatattt gtatctgaga    12660



tagtaaacaa gatggctggc caggtcaaca tggcacctta acttattttt ttaataggta    12720



aaacttcttc aaaagtagct tgctttgtat aagaactaag ctatcagtat agatatagct    12780



atccttggag cttatgtttc agacaagaat tatttactaa aataaataat aaacaagata    12840



atgcattata caatttgggc atttctcgtt tctcaagtgt atgcatcatg gtaaatataa    12900



actaaccaca agataggtag attgattcat ttcattttaa tctccttgtg taattcagta    12960



cctccataat tgttctaatc ttcttcccac tgtttacaaa ttaccagtta attaactcgt    13020



gaaagaaaaa ttcacatatc agaataaaaa taaatgtata ctcactttat aaaaatcacc    13080



actgctgtct ttccttaata ctagcagtgg aaatgtaagt ggcttactct acaaattttg    13140



gtgctggcaa atacataggc aaactgttgg gagctgctct agttacattc ctcccttctt    13200



attccctttt tctcttcctc actttattgc ataacatatt cctgtaccca aagcattcta    13260



ccacagttct atttgactcc cacttgtaat aactccttta aaaaattcca tgtttaacca    13320



tatgaccctg cttgcttact catattctcc ctccctctcc ccttcctttc tctctcttcc    13380



agaagtcatt tgcctggttt gaaatatttt gtagggattg cttattatat tattttagct    13440



gatgaacctc aggacaacgt ctacacacac acacatacat acacgcacac aaaatctcag    13500



ctgttgaaga gtgggcttgg aatcagactt ctgtgtccag taaaaaactc ctgcactgaa    13560



gtcattgtga cttgagtagt tacagactga ttccagtgaa cttgatctaa tttcttttga    13620



tctaatgaat gtgtctgctt accttgtttc cttttaattg ataagctcca agtagttgct    13680



aattttttga caactttaaa tgagtttcat tcacttcttt tacttaatgt tttaagtata    13740



gtaccaataa tttcattaac ctgttctcaa gtggtttagc taccattctg ccatttttaa    13800



tttttattta attttatttg cttgagcaca ctgatcaacc actgaactgc cttcttccat    13860



tgtcctgcaa tgatataagg gttacatttt tgtgtatatg gctttcatag ttgggatttc    13920



agagcactga taccagatat tttcagtttg ttctctgggg gaatttcatt tgcatctatg    13980



tttttagcta tctgtgataa cttgttaaat attaaaaaga tattttgctt ctattggaac    14040



atttgtatac tcgcaactat atttctgtaa acagctgcag tcaaaaataa aacactgaaa    14100



gttaaaaaaa aaaaaaaaaa aaa                                            14123





<210>  112

<211>  1531

<212>  PRT

<213>  Homo sapiens



<400>  112



Met Pro Ser Asp Phe Ile Ser Leu Leu Ser Ala Asp Leu Asp Leu Glu 

1               5                   10                  15      





Ser Pro Lys Ser Leu Tyr Ser Arg Glu Ser Val Tyr Asp Leu Leu Pro 

            20                  25                  30          





Lys Glu Leu Gln Leu Pro Pro Ser Arg Glu Thr Ser Val Ala Ser Met 

        35                  40                  45              





Ser Gln Thr Ser Gly Gly Glu Ala Gly Ser Pro Pro Pro Ala Val Val 

    50                  55                  60                  





Ala Ala Asp Ala Ser Ser Ala Pro Ser Ser Ser Ser Met Gly Gly Ala 

65                  70                  75                  80  





Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile Tyr Ser Thr Ser 

                85                  90                  95      





Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys Ser Ser Ala Val 

            100                 105                 110         





Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu Thr Ser Asn Thr 

        115                 120                 125             





Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr Val Leu Tyr Ile 

    130                 135                 140                 





Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg Met Ser Cys Gln 

145                 150                 155                 160 





Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys Ser Met Trp Met 

                165                 170                 175     





Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr Ser Ser Tyr Asn 

            180                 185                 190         





Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg Asn Pro Lys Gln 

        195                 200                 205             





Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser Asn Met Asp Ile 

    210                 215                 220                 





Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val Leu Ser Gln Leu 

225                 230                 235                 240 





Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn Gly Thr Leu Glu 

                245                 250                 255     





Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met Leu Cys Gly Gln 

            260                 265                 270         





Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile Val Val Gln Pro 

        275                 280                 285             





Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly Ser Arg Gly Ser 

    290                 295                 300                 





Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val Lys Leu Glu Gly 

305                 310                 315                 320 





His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly Asn Asp Ser Gly 

                325                 330                 335     





Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg Val Thr Gly Arg 

            340                 345                 350         





Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly Thr Thr Val Ile 

        355                 360                 365             





Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu Ala Val Asp Cys 

    370                 375                 380                 





Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu Ala Arg Ile Gly 

385                 390                 395                 400 





Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg Leu Val Phe Arg 

                405                 410                 415     





Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr Leu Gln Thr Pro 

            420                 425                 430         





Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val Pro Glu Ile Leu 

        435                 440                 445             





Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu Glu Glu Val Phe 

    450                 455                 460                 





Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val Ile Phe Gln Glu 

465                 470                 475                 480 





Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala Glu Ile Asp Met 

                485                 490                 495     





Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val Pro Pro Tyr His 

            500                 505                 510         





Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile Tyr Val Val Thr 

        515                 520                 525             





Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr Tyr Thr Pro Asp 

    530                 535                 540                 





Pro Ala Ala Ala Gly Ala Leu Asn Val Asn Val Lys Lys Glu Ile Ser 

545                 550                 555                 560 





Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met Lys Ala Met Lys 

                565                 570                 575     





Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile Pro Asn Ala Leu 

            580                 585                 590         





Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser Glu Asp Val Thr 

        595                 600                 605             





Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr Ile Phe Lys Thr 

    610                 615                 620                 





Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu Asn Ile Ser Asn 

625                 630                 635                 640 





Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser Ser His Leu Pro 

                645                 650                 655     





Ser Glu Asn Glu Lys Gln Gln Gln Ile Gln Pro Lys Ala Tyr Asn Pro 

            660                 665                 670         





Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser Gln Pro Gly Thr 

        675                 680                 685             





Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn Ser Asp Ala Leu 

    690                 695                 700                 





Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr Gln Ser Arg Glu 

705                 710                 715                 720 





Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser Gln Leu Thr Glu 

                725                 730                 735     





Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu Gln Ala Gln Thr 

            740                 745                 750         





Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser Pro Asn Ser Val 

        755                 760                 765             





Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala Gly Ser Phe Thr 

    770                 775                 780                 





Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp Leu Val Gln Gln 

785                 790                 795                 800 





Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu Phe Ser Ala Pro 

                805                 810                 815     





Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala Asp Ile Phe Gln 

            820                 825                 830         





Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly Met Phe Ser Ser 

        835                 840                 845             





Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu Leu Pro Gly Arg 

    850                 855                 860                 





Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu Ser Asn Gln Gln 

865                 870                 875                 880 





Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser Ser Ala Ala Met 

                885                 890                 895     





Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala Ala Gln Ile Gln 

            900                 905                 910         





Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly Asn Leu Gln Gln 

        915                 920                 925             





Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser Ala Leu Ser Thr 

    930                 935                 940                 





Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser Ser Pro Pro Ala 

945                 950                 955                 960 





Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln Gln Val Ala Thr 

                965                 970                 975     





Pro Gly Thr Thr Met Phe Gln Thr Ser Ser Ser Gly Asp Gly Glu Glu 

            980                 985                 990         





Thr Gly Thr Gln Ala Lys Gln Ile  Gln Asn Ser Val Phe  Gln Thr Met 

        995                 1000                 1005             





Val Gln  Met Gln His Ser Gly  Asp Asn Gln Pro Gln  Val Asn Leu 

    1010                 1015                 1020             





Phe Ser  Ser Thr Lys Ser Met  Met Ser Val Gln Asn  Ser Gly Thr 

    1025                 1030                 1035             





Gln Gln  Gln Gly Asn Gly Leu  Phe Gln Gln Gly Asn  Glu Met Met 

    1040                 1045                 1050             





Ser Leu  Gln Ser Gly Asn Phe  Leu Gln Gln Ser Ser  His Ser Gln 

    1055                 1060                 1065             





Ala Gln  Leu Phe His Pro Gln  Asn Pro Ile Ala Asp  Ala Gln Asn 

    1070                 1075                 1080             





Leu Ser  Gln Glu Thr Gln Gly  Ser Leu Phe His Ser  Pro Asn Pro 

    1085                 1090                 1095             





Ile Val  His Ser Gln Thr Ser  Thr Thr Ser Ser Glu  Gln Met Gln 

    1100                 1105                 1110             





Pro Pro  Met Phe His Ser Gln  Ser Thr Ile Ala Val  Leu Gln Gly 

    1115                 1120                 1125             





Ser Ser  Val Pro Gln Asp Gln  Gln Ser Thr Asn Ile  Phe Leu Ser 

    1130                 1135                 1140             





Gln Ser  Pro Met Asn Asn Leu  Gln Thr Asn Thr Val  Ala Gln Glu 

    1145                 1150                 1155             





Ala Phe  Phe Ala Ala Pro Asn  Ser Ile Ser Pro Leu  Gln Ser Thr 

    1160                 1165                 1170             





Ser Asn  Ser Glu Gln Gln Ala  Ala Phe Gln Gln Gln  Ala Pro Ile 

    1175                 1180                 1185             





Ser His  Ile Gln Thr Pro Met  Leu Ser Gln Glu Gln  Ala Gln Pro 

    1190                 1195                 1200             





Pro Gln  Gln Gly Leu Phe Gln  Pro Gln Val Ala Leu  Gly Ser Leu 

    1205                 1210                 1215             





Pro Pro  Asn Pro Met Pro Gln  Ser Gln Gln Gly Thr  Met Phe Gln 

    1220                 1225                 1230             





Ser Gln  His Ser Ile Val Ala  Met Gln Ser Asn Ser  Pro Ser Gln 

    1235                 1240                 1245             





Glu Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 

    1250                 1255                 1260             





Gln Gln  Gln Ser Ile Leu Phe  Ser Asn Gln Asn Thr  Met Ala Thr 

    1265                 1270                 1275             





Met Ala  Ser Pro Lys Gln Pro  Pro Pro Asn Met Ile  Phe Asn Pro 

    1280                 1285                 1290             





Asn Gln  Asn Pro Met Ala Asn  Gln Glu Gln Gln Asn  Gln Ser Ile 

    1295                 1300                 1305             





Phe His  Gln Gln Ser Asn Met  Ala Pro Met Asn Gln  Glu Gln Gln 

    1310                 1315                 1320             





Pro Met  Gln Phe Gln Ser Gln  Ser Thr Val Ser Ser  Leu Gln Asn 

    1325                 1330                 1335             





Pro Gly  Pro Thr Gln Ser Glu  Ser Ser Gln Thr Pro  Leu Phe His 

    1340                 1345                 1350             





Ser Ser  Pro Gln Ile Gln Leu  Val Gln Gly Ser Pro  Ser Ser Gln 

    1355                 1360                 1365             





Glu Gln  Gln Val Thr Leu Phe  Leu Ser Pro Ala Ser  Met Ser Ala 

    1370                 1375                 1380             





Leu Gln  Thr Ser Ile Asn Gln  Gln Asp Met Gln Gln  Ser Pro Leu 

    1385                 1390                 1395             





Tyr Ser  Pro Gln Asn Asn Met  Pro Gly Ile Gln Gly  Ala Thr Ser 

    1400                 1405                 1410             





Ser Pro  Gln Pro Gln Ala Thr  Leu Phe His Asn Thr  Ala Gly Gly 

    1415                 1420                 1425             





Thr Met  Asn Gln Leu Gln Asn  Ser Pro Gly Ser Ser  Gln Gln Thr 

    1430                 1435                 1440             





Ser Gly  Met Phe Leu Phe Gly  Ile Gln Asn Asn Cys  Ser Gln Leu 

    1445                 1450                 1455             





Leu Thr  Ser Gly Pro Ala Thr  Leu Pro Asp Gln Leu  Met Ala Ile 

    1460                 1465                 1470             





Ser Gln  Pro Gly Gln Pro Gln  Asn Glu Gly Gln Pro  Pro Val Thr 

    1475                 1480                 1485             





Thr Leu  Leu Ser Gln Gln Met  Pro Glu Asn Ser Pro  Leu Ala Ser 

    1490                 1495                 1500             





Ser Ile  Asn Thr Asn Gln Asn  Ile Glu Lys Ile Asp  Leu Leu Val 

    1505                 1510                 1515             





Ser Leu  Gln Asn Gln Gly Asn  Asn Leu Thr Gly Ser  Phe 

    1520                 1525                 1530     





<210>  113

<211>  14177

<212>  DNA

<213>  Homo sapiens



<400>  113

tgcaacggaa acttttggct ccacgaacag aaaagcaaga gcaaaaactc agttaaatgc       60



gttcttcctc catctttgcc tagtccaaaa ggaaaaaaaa agaaacagaa aaaagaaaaa      120



ctgtttggaa gagtagcgtt gaggtttgct ttttacctgt ttttcctcta gaacagccag      180



gtggattcac atgatccaat tttttaattg tcttctatgt cccactccga ataacccgga      240



tgccccagca caatcagaga gatcgttttt tttaaaaaaa atttcagcct ccaaaggtag      300



gaggggagtg ttaggggaga aagtacttta attaaaaatc aataactcga ggtttttggg      360



atacggtttg ccatttccta attaagaaat gggtttgaca gtccctttgt acacactgct      420



atgcaaaccc caaagggttg gcggctgtcc gggcgatgac actccggtcc cctgcgagac      480



cccgggccag ccaggcccgt ccgccgccgg cctctggggt ccgtccccgg ctcgcgcaga      540



cctctcgctt ctctcggctc tgtctcctgc gctcagctct gctcggggcc ggccgcctca      600



ggctcgccgc caccaggtcg ttgcaaatac cttttccctc cccggggccc cagcgcgcgg      660



ccacctccca gcctcccccc ctcccaccct ggcagcgggg ccctttcccg gctcaggaac      720



agcagcagcc cgggccgcgc cggcaggaag cgaggcccat gttgctgctg ttccctggcg      780



cgcctccccg ccctccgggg gccgccacgg ctcttccgcg ctcccgggca cccccctccg      840



cgcctgcgct gtgccccacg ggggcggggc tcagattcct gtcagcggcg gcggcggtgg      900



cggcgaccgt cagttttcgc tgaggagaaa cacgaaacgg accctttggc tctccccctt      960



ccccttcccc gtcctgaacc cctctcctgg tcaccgagaa tcagtccccg tggagttccc     1020



cctccacctc gccatcgttt cctcggtcct cggcccagtg gaagtcacta ccctcgagga     1080



ggaggcagcg gcagccgccc tcgcgtcgcc gcccccggtt cggtgcccgc ggtcccggag     1140



aggaggtgcc gccgccaccg ccgctccccc cctcccgctg ccctcgggcc gggctgggtc     1200



gagctgcgat gccctcggac ttcatctcat tgctcagcgc ggacctagac ctggaatcgc     1260



ccaagtccct ctactcgcga gattctctga agttacaccc atcacagaat tttcatagag     1320



ctggactatt ggaagaatct gtctatgatc ttctcccaaa ggagttacag ttacctccat     1380



ctagagaaac atctgtagca tcaatgagtc agacaagcgg tggtgaggca ggctcgcctc     1440



ctccagctgt tgttgctgct gatgcttctt cagctccctc ctcttcctcc atgggcggtg     1500



cttgcagctc ctttaccacc tcttccagcc ctaccattta ttctacctca gtcaccgaca     1560



gcaaggctat gcaagtggag agctgctcct cagccgtggg ggtaagtaac agaggggtaa     1620



gtgaaaagca gttaaccagt aacacagttc agcagcatcc atcaacaccg aagaggcaca     1680



cagtcttgta catctcacca ccacctgagg acttgctgga taacagtcgg atgtcctgcc     1740



aggatgaggg gtgtggattg gaatctgagc agagctgcag tatgtggatg gaggattccc     1800



cctccaactt cagtaacatg agcaccagtt cctacaatga taacactgag gtacctcgta     1860



aatcacgaaa acgaaatcca aagcagaggc cgggggtcaa acgacgagat tgtgaagaat     1920



ctaatatgga tatatttgat gccgacagtg ccaaagcacc tcactatgtg ctttctcagc     1980



ttaccacgga caacaaaggc aactcaaaag cgggaaatgg aacattggaa aaccaaaaag     2040



gaactggagt aaagaagagc cctatgttgt gtggacaata tcctgttaaa agtgagggaa     2100



aggagctgaa gatagttgta caacctgaga cacagcaccg agctcggtac ctgactgagg     2160



gcagccgtgg ctcagtgaaa gatagaacac agcaaggctt tcctacagta aagctggaag     2220



gccataatga acctgtagtg ttgcaagtgt ttgtgggcaa cgactctgga cgagtgaaac     2280



cacatggatt ttatcaggcc tgcagagtaa ctggacgaaa tacaactcct tgcaaagaag     2340



tggacattga aggcactact gttatagaag tcggccttga tcctagcaac aacatgacac     2400



tggcggtgga ctgcgtaggg atattgaaat tgaggaatgc tgatgtcgaa gccagaatag     2460



gaattgctgg ttccaagaag aaaagcactc gtgccagatt ggtttttcga gttaatatca     2520



tgaggaaaga tggctccact ttgacactgc aaacaccctc ttctccaatt ttgtgtactc     2580



agccagcagg agtgccagaa atcttaaaga aaagcttgca tagctgttca gtgaaaggag     2640



aagaagaagt gtttttaatc ggcaagaact ttctgaaagg aactaaagtt attttccaag     2700



aaaatgtttc tgatgaaaac tcttggaagt cagaagctga aattgatatg gaactatttc     2760



atcagaatca tcttattgtg aaggttcctc cctatcatga ccaacatata actttgcctg     2820



tgtcagtggg aatatatgta gtgacaaatg ctggaagatc tcatgatgtt caaccattca     2880



cttacactcc agacccagca gcagctggtg ctttgaatgt aaatgtgaag aaggaaatat     2940



ctagtccagc aagaccttgc tcttttgaag aggccatgaa agcaatgaaa actactggat     3000



gtaatttaga taaggtaaat attatcccta atgccctgat gactccactc ataccaagca     3060



gtatgattaa gagtgaagat gttactccaa tggaagtaac agcagaaaaa agatcttcca     3120



ctatttttaa gactacaaag tctgttggat caactcagca aacattagaa aacatctcaa     3180



acatagcagg aaatggctct ttttcatcac catcatcttc ccacctacct tctgaaaatg     3240



aaaaacagca gcagattcag cccaaggcat acaacccaga gaccctgaca actattcaaa     3300



cccaggacat ctcacagcct ggtacttttc cagcagtttc tgcttctagt cagctgccca     3360



acagcgatgc actattgcag caggctacac agtttcagac aagagaaact cagtctagag     3420



agatattaca gtcagatggt acagtggtta atttgtcaca actgactgag gcatcacaac     3480



aacagcagca gtcaccacta caagaacaag cacagacttt acagcagcag atttcatcaa     3540



atatttttcc atcaccaaat agtgtgagtc agcttcagaa tactattcag cagctgcaag     3600



cagggagttt cacaggcagt actgctagtg gcagcagtgg aagtgttgac ttggtccaac     3660



aagttttaga ggcacagcag cagttatctt cagttttatt ttctgctcca gatggtaatg     3720



agaatgttca agagcagctt agtgcagata tttttcaaca agtcagtcaa attcagagtg     3780



gtgtaagccc tggaatgttt tcctcaacag agccaacagt ccataccaga ccagataatt     3840



tattacctgg aagagctgaa agtgttcatc cacagtctga aaacacgtta tctaatcaac     3900



agcagcagca gcagcagcaa cagcaagtga tggaatcttc agccgcaatg gtgatggaga     3960



tgcaacagag tatctgccag gcagctgccc agattcagtc agagttattc ccttcaactg     4020



cttcagcaaa tggaaacctt cagcaatcgc cagtttacca gcagacttct cacatgatga     4080



gtgcattgtc taccaatgag gatatgcaaa tgcagtgtga attgttttct tctcctcctg     4140



cagtttctgg aaatgaaact tctacaacta ccacacagca ggttgcaacc cctggcacta     4200



ccatgtttca gacatcaagt tcaggagatg gagaagaaac tggaacacaa gcaaaacaga     4260



ttcagaacag tgtctttcag accatggtcc aaatgcaaca tagtggggac aatcaacctc     4320



aagttaacct tttttcatcc acaaaaagta tgatgagtgt tcagaatagt ggtacccaac     4380



aacaaggtaa tggtttattc cagcaaggga atgagatgat gtcacttcaa tctggaaatt     4440



ttttgcagca gtcttctcat tcacaggccc aactttttca tcctcaaaat cctattgccg     4500



atgctcagaa cctttcccag gaaactcaag gttctctctt tcatagtcca aatcctattg     4560



tccacagtca gacttctaca acctcctctg aacaaatgca gcctccaatg tttcactctc     4620



aaagtaccat tgctgtgtta cagggctctt cagttcctca agaccagcag tcaaccaaca     4680



tatttctttc ccagagtccc atgaataatc ttcagactaa cacagtagcc caagaagcat     4740



tttttgcagc accgaactca atttctccac ttcagtcaac atcaaacagt gaacaacaag     4800



ctgctttcca acagcaagct ccaatatcac acatccagac tcctatgctt tcccaagaac     4860



aggcacaacc cccgcagcag ggtttatttc agcctcaggt ggccctgggc tcccttccac     4920



ctaatccaat gcctcaaagc caacaaggaa ccatgttcca gtcacagcac tcaatagttg     4980



ccatgcagag taactctcca tcccaggaac agcagcagca gcagcaacag cagcagcaac     5040



agcagcagca acaacaacag agcattttat tcagtaatca gaataccatg gctacaatgg     5100



cgtctccaaa gcaaccacca ccaaacatga tattcaaccc aaatcaaaat ccaatggcta     5160



atcaggagca acagaaccag tcaatttttc accaacaaag taacatggcc ccaatgaatc     5220



aagagcaaca gcccatgcaa tttcagagtc agtccacagt ttcctcactt cagaacccag     5280



gtcctaccca gtcggaatca tcacagaccc ccttgttcca tagctctcct cagattcagt     5340



tggtacaagg gtcacctagt tctcaagagc agcaagtaac tctcttctta tctccagcat     5400



ccatgtctgc cttgcagacc agtataaatc aacaagatat gcaacagtct cctctttatt     5460



cccctcagaa caacatgcct ggaattcaag gagccacatc ttcgcctcaa ccacaggcta     5520



ctttatttca caacacagca ggaggcacaa tgaaccaact gcagaattct cctggctcat     5580



ctcagcagac atcaggaatg ttcttatttg gcattcaaaa taactgtagt cagcttttaa     5640



cctctggacc agctacattg cctgatcagt tgatggccat aagtcagcca ggccaaccac     5700



aaaacgaggg ccagccacct gtgacaacac ttctttctca gcaaatgcca gagaattctc     5760



cactggcatc ctctataaac accaaccaga acatcgaaaa gattgatttg cttgtttcat     5820



tgcaaaacca agggaacaac ttgactggct ccttttaact ggatataaat tccacgaaga     5880



aaatcctgat tccaagatgt cctgagatct tgtggttcca tgagaattat tactttaaaa     5940



acaaaacaaa atataaaaaa ctgtgtttga gtaaactgat agattttact ctgactgcaa     6000



aagagcacac ctatgctgct tgttgcagta actaaccacc aatgttaaca tcttcatatt     6060



ttatattcct aataacagtg atgactgaga atctatttga gtttccagct ggcagaatta     6120



attgttatta ttttcctagg cgcaatttcc ttaaacgtac agtttaaatt caaggctgga     6180



ccactcagtt attattgcta ttagaaaata atatatcatg tttacttttg ttcttcatta     6240



ttttctttcc tgcattgttt tagtcaagta atggcttttg aaaaagtaaa gttcaataat     6300



aactaaggct gtgatttttt tcaatataaa aggcacagct gttggccaaa gtgaaggaat     6360



cttttttcag ttttattgga gaaactgaag ggtaacattc taacaagtaa actgtatgtg     6420



cagataaaag tactcttgat ttaacacaaa ggcagatgat acacttataa aactgggaac     6480



agctggaatg cttcttgatt ttattttttc agagagttgt tagttctctg ggtttctact     6540



aaggggttta gccataactg tgcatagaaa aataattatc tgtaaaaaat gaaggggata     6600



atatatgata aattatgttc tgatatcctc ctacagtagt ttaaattgac agaaaaattt     6660



gaatgttttc ttcttaaccc agtcttaggc tggtattccc tttttatata tatctatatt     6720



acttttcacc tctttttcac tttactttag agaactatta atatactact ggcttcatga     6780



ccctgtagca tctttggcca ctttaatcta gggtgaccta gcaatcctgc agcacagggc     6840



agagagtact gtcttaggaa ttattaggag ttgattcctg agaaacaaca catttttccc     6900



catgaacggt gctgttctga agtcttcaaa tttttccctc taataggaaa cagtataaat     6960



tttaattaaa aaaaaaaggc aaactaaaat ttcttgaaat atcacttctc cctgatctgc     7020



agtgagtata aattcacttg tcacctcagt gctttacagt ttgaagtggt cacttacctg     7080



atggttccca caagccttag gctttacagg gttgtatcat tgacttaaaa tgaagaatta     7140



acttgtgtta catctataaa gagcaaaata acacactcca gaacttggca gttgtagcat     7200



tagttataca gttttgggtg ttcttgccac ccgtgggatg cctgcttctc actaccacct     7260



gtgtctggac acatgcttat gtctcatttt ccttttggca tgtggaaagc tgtcaatgca     7320



gtgtaaggcc aacgtgtgtg tggcttctat gtgttgagat aatgttttgg tatccttgtc     7380



cgtttcattt attttttaag tgtacaaaaa ataacctgtt aattgttgaa ggctactttt     7440



ctgttctttt tttttttttt tttctatcct gtacatttag ttgaactgtg cggaattgtg     7500



gtgttggttt tgtttacaca gccagatttt tccttctttt tgttttgtga tgatcttcct     7560



ttgttctttg aatgtgctct tttgtctttt tctctttttt ctcatgtttt cttccctcca     7620



cctccacccc tttctttctt tctctctctg attgagaggc attgaattac gttttcagta     7680



gtacaggctt cttgccgata tgaagggaac ttttcagaaa gagacctact ctgggtcatt     7740



taattttgaa tacagttttc aatcgttcaa gttttggatg gtttatatct aatgtgtgtt     7800



tcattttttt ggaaagctat attttgtatt taggaaatgg tatactattt tgctatttgt     7860



actgagtgag tacattggca taaatataga aatttatata tatacatata tataaactat     7920



tcttttttgc cacacatttt tgtggtaaat ttgtgagttt gtctgatgtt ctaccacaac     7980



gtggcgtctg ataacagtga gggggggtgg ggtttgttat gtctttattg agtatttaag     8040



tatcttttga aacaaatgac ctgttcatct gtggccattc catcaggcag ttagttcctt     8100



gatgtcagta gtgggctaaa ggcagcttac tgtgtgtttg ctggagcttt cactcagcca     8160



agtgttagag tcaggaaacc cattgaggca atggcgtcaa atggtgtttc acaagaatga     8220



gccattcagt ctttgctcac tatatattta atattttatt attgttgtta ttgttattat     8280



taattggctt tctgtattct atgcctttta tttataaaga cactaagaaa acccatgttt     8340



gtaattttaa taacattttt cccatcttgt aatatccaga gctactttat aaattctctg     8400



aaccaaaagt attttcctca gtgtatctct tctcccccag cccctattgg gaaaaattac     8460



ccagtatagt tcaggttatg aggaggatca gccacacaat ccagtgcttc agtttgaaaa     8520



tgtaaaattc taaccctaaa gtagggttgg ttgaaatttc agacaaagca aacccagcag     8580



gtataaaaag tagtataaat acaaatctgt aagttatttt tgaattttct gaactttttt     8640



ctaagagatt acataggaga ctaaagaaat ctatctgttc aagttctaat taggatgatt     8700



gttaatactg cactgtggat gaagtggcga ctggcttgtg tgctgacttc tgtggtttag     8760



caagaggttt attgttatca aatgctaatt ggcaatgcca agtcactggg accaattttc     8820



tgttttataa tatctaagtt tagaacagaa tatatacctg aactgtagtg gtttgatcgg     8880



atggagacag aaaacccgat ttttattctc ataaattttg tggttattta tacaagggct     8940



gtgctatgct accatattct tgttcaataa taataggttt gttgtttttt ttacattgtt     9000



aaatgttcct tacccctaaa ggtcaatgtt aagtacaaca ttctgaaaat acaatttggc     9060



tacgaagagt attcatcttc tttgaagctc agtggttgat atttgtgcta ataatgcaat     9120



ttcctgatta ctgttacaag ttatagctac atatgggaga gactcagtga gccagcaaag     9180



gccatagaaa caacaattta ttaaatgtat ttatggcaga aggacctaaa taaactgtga     9240



gccacctttt cttctttata ttgttacatt taagtgttct tgctttcagc aactcacatt     9300



aatgcttgga gcttatctct ttctctctct ctctctctct ctctgtgtgt gtgtgtgtat     9360



gtgtgtgtgt gtgtgtgtgt gtttccttat tgtcattcca ttatatatcc acaccaacat     9420



gggtgacgat aattcaaagt catattttgc ctctaagctt gatcatgtta cctttatgat     9480



taaagtatca tgttatttag ccaatgcaaa tctgttttaa aacaaatagt ttaaaaaaag     9540



aacaagtttt taagggcttt attatagaag aagtattaat gaaggacttt ccttcctccc     9600



tccctttcct cccctccctg cctcccttct tcccttccat ctccccctcc tccctgcctt     9660



ctttgtttct ccttccctta ttcctccctc cctcctttct cccttccttc ctttcttcca     9720



ttcatccttc cttgcctttt atttttattt tttgtaatat cacatgtgct gtagtttgga     9780



attttattct agtgcatttc ttgctcatca gaacctcagc taatctacct aggaaaaata     9840



gtatcaaagg aaatgagaaa gttgtatctg agtccctcca gaactaagat aattcttttt     9900



gaccatttaa gcctttataa atgcgttttg accatttaag cctttataaa tgcttgtttt     9960



aggaaagtga atctgttaga tgcatcaaca aataatgacc aggacaaaac gatttaataa    10020



ttaaagtctc aaatcaccat ggttatacat tttcaccaga aatagtaatc ttacaatttt    10080



tcatttttct gatgaagatt tctgttccaa tatctgtttc ctaatagatt ttttaaatta    10140



attagctttc ctctgcttta tgaccacagg ttttatccct aaccgagaca gctgtcttat    10200



atctgcatgc cttagactgt gtggagggac tccatgaaga aagaccatag gttagaaaaa    10260



taactcatag tatataccct agtaagtggg ttagtagaat ctcataacat gtattaaaaa    10320



gaggttttct tctctgcttg tttgtgtcac tagagcaaaa ttgtagagat aatgctcata    10380



atgcagtaaa tatcagaata atatctacaa tatcatttgt ggatggtccc aggtcccagt    10440



gctctagtta ctttacttct tttttttttt ttgagatgga gtcttgctct gtctctcagg    10500



ctagagcagt gtgcgatctc agctcactgc agcctccacc tcccaggttc aagcgattct    10560



cctgcctcag cctcccaagt agccaggatt acaggcaccc tccactaggc ccggctaatt    10620



ttttttgtat ttttttagta gagatggggt tttgccatgt tggccaggct ggtttcgaac    10680



tcctaacctc cagtgatcca cctgcctcgg cgtcccaaag tgctaggatt acaggcatga    10740



gccaccacat ccggcctaat tacttcttta atccccattt atttttatgc cattctagcc    10800



tcatttatta ataaaattat gtttttactt tctctttcag gaaatttttt aaattaatat    10860



tttatatcta gatctaatgc tatggaaaag tgccttttta tcatttataa tttcattttt    10920



cactatttcc aaaaacacat aaacaaatag tttcagtagg tcccagcttt tactttttcc    10980



atttaaacct tcttttctcc atttcttccc tttggcttaa gaataaaaga aaaggtacat    11040



tgctagaatt gtttctttgg gagagggtaa aagattacag aattagactg ttcagccttt    11100



atataaacta aatttgtctt catctcaacc agctaatggt aggtcttatc tgaatactca    11160



tgagaatttt agcatctgtg aaactccatg caccagatgt gtgtaaattt caggaagaaa    11220



gtgttgaaag cattttctct gatgttaatt agatggaaat aaatcactaa aacatagttt    11280



aggtaaagcc tgattatgcc actttttttt aactagacag ggcaaagttg tttatgttag    11340



tgtacttctt gtctatcctc agttaattta cctagacaaa aagtgtcaaa ggaaatgaga    11400



aaaaggttat atctgactcc ctccagacct aagataattc cttttgatca gatacagtca    11460



gatggagtgc cttggttttt gttaattttg cctctattcc agctccttac cacagcggtg    11520



gtgcttaaag aaaggatcat cagcaacagg tcaggatagt tctacctttg ggatagggct    11580



gctttccccg tgctagtatt tctgtgactg ttagtggcac tgaggactgc aaacttttat    11640



gcaatattct taatacccta ttgatattat gcactttaat cattccaaag aagccaagaa    11700



tgctgtatag tgatgattcc ttcctaatga attcatctta actatttaga atgttatgtc    11760



ccttttcttt tggatagcca acttggtata aatgttatat ggatttttct aaaatgacta    11820



tataggactt aagactttga aatgtaattt acttataagg ggaaataatt atgctttagc    11880



acatcatttt agaaacgtca cattttagaa acattcagct tgctaaccta catgtttggg    11940



aattcattaa aaccagttgt ctatatattt tgtgccatgt atataagaac attacaatat    12000



atctttttct acatatgtag tatgtgcaac cagtggttct cagagtatgg ttctcagccc    12060



accagctagt atcagtatca cctgggaact agttagaaat gtaaattctt tggccccatc    12120



ccagacatac tgagtcagaa actctggaat agggcccccg caatctgttt tcacaagccc    12180



tccaggtgat tctgatgcac actttaaagt ttaggaacca ctgggctaag actctgttga    12240



gatatagagt ttttcttcca ctcagactga tatagttata cattgttctt catgtaaatt    12300



cagcttaacc tggttatcta taatctttta ttggcaaaag ttaattctca gtactgccta    12360



tagagataca gtgtatttta tgtacataca caattagtct aattcttgat aattcagtta    12420



atttagtttg gcattttcct accacttact aaaaggttta cattaaatga ctgatttaaa    12480



tatataggtg caatgttcta tgtttatttt aattgttatg acatttaagt agctaatata    12540



attgaccggt gctaaagtct cctgtttatc cataaaatgg gtacattatg ggcagtgtaa    12600



tacaagcttt cttttcattg cctagtactt taccagcaga ccacagtttt gccctggcta    12660



gaccaaccct cagaacaaaa tcatcattcc ttgtatttat atttgtatct gagatagtaa    12720



acaagatggc tggccaggtc aacatggcac cttaacttat ttttttaata ggtaaaactt    12780



cttcaaaagt agcttgcttt gtataagaac taagctatca gtatagatat agctatcctt    12840



ggagcttatg tttcagacaa gaattattta ctaaaataaa taataaacaa gataatgcat    12900



tatacaattt gggcatttct cgtttctcaa gtgtatgcat catggtaaat ataaactaac    12960



cacaagatag gtagattgat tcatttcatt ttaatctcct tgtgtaattc agtacctcca    13020



taattgttct aatcttcttc ccactgttta caaattacca gttaattaac tcgtgaaaga    13080



aaaattcaca tatcagaata aaaataaatg tatactcact ttataaaaat caccactgct    13140



gtctttcctt aatactagca gtggaaatgt aagtggctta ctctacaaat tttggtgctg    13200



gcaaatacat aggcaaactg ttgggagctg ctctagttac attcctccct tcttattccc    13260



tttttctctt cctcacttta ttgcataaca tattcctgta cccaaagcat tctaccacag    13320



ttctatttga ctcccacttg taataactcc tttaaaaaat tccatgttta accatatgac    13380



cctgcttgct tactcatatt ctccctccct ctccccttcc tttctctctc ttccagaagt    13440



catttgcctg gtttgaaata ttttgtaggg attgcttatt atattatttt agctgatgaa    13500



cctcaggaca acgtctacac acacacacat acatacacgc acacaaaatc tcagctgttg    13560



aagagtgggc ttggaatcag acttctgtgt ccagtaaaaa actcctgcac tgaagtcatt    13620



gtgacttgag tagttacaga ctgattccag tgaacttgat ctaatttctt ttgatctaat    13680



gaatgtgtct gcttaccttg tttcctttta attgataagc tccaagtagt tgctaatttt    13740



ttgacaactt taaatgagtt tcattcactt cttttactta atgttttaag tatagtacca    13800



ataatttcat taacctgttc tcaagtggtt tagctaccat tctgccattt ttaattttta    13860



tttaatttta tttgcttgag cacactgatc aaccactgaa ctgccttctt ccattgtcct    13920



gcaatgatat aagggttaca tttttgtgta tatggctttc atagttggga tttcagagca    13980



ctgataccag atattttcag tttgttctct gggggaattt catttgcatc tatgttttta    14040



gctatctgtg ataacttgtt aaatattaaa aagatatttt gcttctattg gaacatttgt    14100



atactcgcaa ctatatttct gtaaacagct gcagtcaaaa ataaaacact gaaagttaaa    14160



aaaaaaaaaa aaaaaaa                                                   14177





<210>  114

<211>  1549

<212>  PRT

<213>  Homo sapiens



<400>  114



Met Pro Ser Asp Phe Ile Ser Leu Leu Ser Ala Asp Leu Asp Leu Glu 

1               5                   10                  15      





Ser Pro Lys Ser Leu Tyr Ser Arg Asp Ser Leu Lys Leu His Pro Ser 

            20                  25                  30          





Gln Asn Phe His Arg Ala Gly Leu Leu Glu Glu Ser Val Tyr Asp Leu 

        35                  40                  45              





Leu Pro Lys Glu Leu Gln Leu Pro Pro Ser Arg Glu Thr Ser Val Ala 

    50                  55                  60                  





Ser Met Ser Gln Thr Ser Gly Gly Glu Ala Gly Ser Pro Pro Pro Ala 

65                  70                  75                  80  





Val Val Ala Ala Asp Ala Ser Ser Ala Pro Ser Ser Ser Ser Met Gly 

                85                  90                  95      





Gly Ala Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile Tyr Ser 

            100                 105                 110         





Thr Ser Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys Ser Ser 

        115                 120                 125             





Ala Val Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu Thr Ser 

    130                 135                 140                 





Asn Thr Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr Val Leu 

145                 150                 155                 160 





Tyr Ile Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg Met Ser 

                165                 170                 175     





Cys Gln Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys Ser Met 

            180                 185                 190         





Trp Met Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr Ser Ser 

        195                 200                 205             





Tyr Asn Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg Asn Pro 

    210                 215                 220                 





Lys Gln Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser Asn Met 

225                 230                 235                 240 





Asp Ile Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val Leu Ser 

                245                 250                 255     





Gln Leu Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn Gly Thr 

            260                 265                 270         





Leu Glu Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met Leu Cys 

        275                 280                 285             





Gly Gln Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile Val Val 

    290                 295                 300                 





Gln Pro Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly Ser Arg 

305                 310                 315                 320 





Gly Ser Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val Lys Leu 

                325                 330                 335     





Glu Gly His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly Asn Asp 

            340                 345                 350         





Ser Gly Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg Val Thr 

        355                 360                 365             





Gly Arg Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly Thr Thr 

    370                 375                 380                 





Val Ile Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu Ala Val 

385                 390                 395                 400 





Asp Cys Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu Ala Arg 

                405                 410                 415     





Ile Gly Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg Leu Val 

            420                 425                 430         





Phe Arg Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr Leu Gln 

        435                 440                 445             





Thr Pro Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val Pro Glu 

    450                 455                 460                 





Ile Leu Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu Glu Glu 

465                 470                 475                 480 





Val Phe Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val Ile Phe 

                485                 490                 495     





Gln Glu Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala Glu Ile 

            500                 505                 510         





Asp Met Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val Pro Pro 

        515                 520                 525             





Tyr His Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile Tyr Val 

    530                 535                 540                 





Val Thr Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr Tyr Thr 

545                 550                 555                 560 





Pro Asp Pro Ala Ala Ala Gly Ala Leu Asn Val Asn Val Lys Lys Glu 

                565                 570                 575     





Ile Ser Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met Lys Ala 

            580                 585                 590         





Met Lys Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile Pro Asn 

        595                 600                 605             





Ala Leu Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser Glu Asp 

    610                 615                 620                 





Val Thr Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr Ile Phe 

625                 630                 635                 640 





Lys Thr Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu Asn Ile 

                645                 650                 655     





Ser Asn Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser Ser His 

            660                 665                 670         





Leu Pro Ser Glu Asn Glu Lys Gln Gln Gln Ile Gln Pro Lys Ala Tyr 

        675                 680                 685             





Asn Pro Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser Gln Pro 

    690                 695                 700                 





Gly Thr Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn Ser Asp 

705                 710                 715                 720 





Ala Leu Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr Gln Ser 

                725                 730                 735     





Arg Glu Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser Gln Leu 

            740                 745                 750         





Thr Glu Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu Gln Ala 

        755                 760                 765             





Gln Thr Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser Pro Asn 

    770                 775                 780                 





Ser Val Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala Gly Ser 

785                 790                 795                 800 





Phe Thr Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp Leu Val 

                805                 810                 815     





Gln Gln Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu Phe Ser 

            820                 825                 830         





Ala Pro Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala Asp Ile 

        835                 840                 845             





Phe Gln Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly Met Phe 

    850                 855                 860                 





Ser Ser Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu Leu Pro 

865                 870                 875                 880 





Gly Arg Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu Ser Asn 

                885                 890                 895     





Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser Ser Ala 

            900                 905                 910         





Ala Met Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala Ala Gln 

        915                 920                 925             





Ile Gln Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly Asn Leu 

    930                 935                 940                 





Gln Gln Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser Ala Leu 

945                 950                 955                 960 





Ser Thr Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser Ser Pro 

                965                 970                 975     





Pro Ala Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln Gln Val 

            980                 985                 990         





Ala Thr Pro Gly Thr Thr Met Phe  Gln Thr Ser Ser Ser  Gly Asp Gly 

        995                 1000                 1005             





Glu Glu  Thr Gly Thr Gln Ala  Lys Gln Ile Gln Asn  Ser Val Phe 

    1010                 1015                 1020             





Gln Thr  Met Val Gln Met Gln  His Ser Gly Asp Asn  Gln Pro Gln 

    1025                 1030                 1035             





Val Asn  Leu Phe Ser Ser Thr  Lys Ser Met Met Ser  Val Gln Asn 

    1040                 1045                 1050             





Ser Gly  Thr Gln Gln Gln Gly  Asn Gly Leu Phe Gln  Gln Gly Asn 

    1055                 1060                 1065             





Glu Met  Met Ser Leu Gln Ser  Gly Asn Phe Leu Gln  Gln Ser Ser 

    1070                 1075                 1080             





His Ser  Gln Ala Gln Leu Phe  His Pro Gln Asn Pro  Ile Ala Asp 

    1085                 1090                 1095             





Ala Gln  Asn Leu Ser Gln Glu  Thr Gln Gly Ser Leu  Phe His Ser 

    1100                 1105                 1110             





Pro Asn  Pro Ile Val His Ser  Gln Thr Ser Thr Thr  Ser Ser Glu 

    1115                 1120                 1125             





Gln Met  Gln Pro Pro Met Phe  His Ser Gln Ser Thr  Ile Ala Val 

    1130                 1135                 1140             





Leu Gln  Gly Ser Ser Val Pro  Gln Asp Gln Gln Ser  Thr Asn Ile 

    1145                 1150                 1155             





Phe Leu  Ser Gln Ser Pro Met  Asn Asn Leu Gln Thr  Asn Thr Val 

    1160                 1165                 1170             





Ala Gln  Glu Ala Phe Phe Ala  Ala Pro Asn Ser Ile  Ser Pro Leu 

    1175                 1180                 1185             





Gln Ser  Thr Ser Asn Ser Glu  Gln Gln Ala Ala Phe  Gln Gln Gln 

    1190                 1195                 1200             





Ala Pro  Ile Ser His Ile Gln  Thr Pro Met Leu Ser  Gln Glu Gln 

    1205                 1210                 1215             





Ala Gln  Pro Pro Gln Gln Gly  Leu Phe Gln Pro Gln  Val Ala Leu 

    1220                 1225                 1230             





Gly Ser  Leu Pro Pro Asn Pro  Met Pro Gln Ser Gln  Gln Gly Thr 

    1235                 1240                 1245             





Met Phe  Gln Ser Gln His Ser  Ile Val Ala Met Gln  Ser Asn Ser 

    1250                 1255                 1260             





Pro Ser  Gln Glu Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 

    1265                 1270                 1275             





Gln Gln  Gln Gln Gln Gln Ser  Ile Leu Phe Ser Asn  Gln Asn Thr 

    1280                 1285                 1290             





Met Ala  Thr Met Ala Ser Pro  Lys Gln Pro Pro Pro  Asn Met Ile 

    1295                 1300                 1305             





Phe Asn  Pro Asn Gln Asn Pro  Met Ala Asn Gln Glu  Gln Gln Asn 

    1310                 1315                 1320             





Gln Ser  Ile Phe His Gln Gln  Ser Asn Met Ala Pro  Met Asn Gln 

    1325                 1330                 1335             





Glu Gln  Gln Pro Met Gln Phe  Gln Ser Gln Ser Thr  Val Ser Ser 

    1340                 1345                 1350             





Leu Gln  Asn Pro Gly Pro Thr  Gln Ser Glu Ser Ser  Gln Thr Pro 

    1355                 1360                 1365             





Leu Phe  His Ser Ser Pro Gln  Ile Gln Leu Val Gln  Gly Ser Pro 

    1370                 1375                 1380             





Ser Ser  Gln Glu Gln Gln Val  Thr Leu Phe Leu Ser  Pro Ala Ser 

    1385                 1390                 1395             





Met Ser  Ala Leu Gln Thr Ser  Ile Asn Gln Gln Asp  Met Gln Gln 

    1400                 1405                 1410             





Ser Pro  Leu Tyr Ser Pro Gln  Asn Asn Met Pro Gly  Ile Gln Gly 

    1415                 1420                 1425             





Ala Thr  Ser Ser Pro Gln Pro  Gln Ala Thr Leu Phe  His Asn Thr 

    1430                 1435                 1440             





Ala Gly  Gly Thr Met Asn Gln  Leu Gln Asn Ser Pro  Gly Ser Ser 

    1445                 1450                 1455             





Gln Gln  Thr Ser Gly Met Phe  Leu Phe Gly Ile Gln  Asn Asn Cys 

    1460                 1465                 1470             





Ser Gln  Leu Leu Thr Ser Gly  Pro Ala Thr Leu Pro  Asp Gln Leu 

    1475                 1480                 1485             





Met Ala  Ile Ser Gln Pro Gly  Gln Pro Gln Asn Glu  Gly Gln Pro 

    1490                 1495                 1500             





Pro Val  Thr Thr Leu Leu Ser  Gln Gln Met Pro Glu  Asn Ser Pro 

    1505                 1510                 1515             





Leu Ala  Ser Ser Ile Asn Thr  Asn Gln Asn Ile Glu  Lys Ile Asp 

    1520                 1525                 1530             





Leu Leu  Val Ser Leu Gln Asn  Gln Gly Asn Asn Leu  Thr Gly Ser 

    1535                 1540                 1545             





Phe 

    





<210>  115

<211>  14239

<212>  DNA

<213>  Homo sapiens



<400>  115

tgcaacggaa acttttggct ccacgaacag aaaagcaaga gcaaaaactc agttaaatgc       60



gttcttcctc catctttgcc tagtccaaaa ggaaaaaaaa agaaacagaa aaaagaaaaa      120



ctgtttggaa gagtagcgtt gaggtttgct ttttacctgt ttttcctcta gaacagccag      180



gtggattcac atgatccaat tttttaattg tcttctatgt cccactccga ataacccgga      240



tgccccagca caatcagaga gatcgttttt tttaaaaaaa atttcagcct ccaaaggtag      300



gaggggagtg ttaggggaga aagtacttta attaaaaatc aataactcga ggtttttggg      360



atacggtttg ccatttccta attaagaaat gggtttgaca gtccctttgt acacactgct      420



atgcaaaccc caaagggttg gcggctgtcc gggcgatgac actccggtcc cctgcgagac      480



cccgggccag ccaggcccgt ccgccgccgg cctctggggt ccgtccccgg ctcgcgcaga      540



cctctcgctt ctctcggctc tgtctcctgc gctcagctct gctcggggcc ggccgcctca      600



ggctcgccgc caccaggtcg ttgcaaatac cttttccctc cccggggccc cagcgcgcgg      660



ccacctccca gcctcccccc ctcccaccct ggcagcgggg ccctttcccg gctcaggaac      720



agcagcagcc cgggccgcgc cggcaggaag cgaggcccat gttgctgctg ttccctggcg      780



cgcctccccg ccctccgggg gccgccacgg ctcttccgcg ctcccgggca cccccctccg      840



cgcctgcgct gtgccccacg ggggcggggc tcagattcct gtcagcggcg gcggcggtgg      900



cggcgaccgt cagttttcgc tgaggagaaa cacgaaacgg accctttggc tctccccctt      960



ccccttcccc gtcctgaacc cctctcctgg tcaccgagaa tcagtccccg tggagttccc     1020



cctccacctc gccatcgttt cctcggtcct cggcccagtg gaagtcacta ccctcgagga     1080



ggaggcagcg gcagccgccc tcgcgtcgcc gcccccggtt cggtgcccgc ggtcccggag     1140



aggaggtgcc gccgccaccg ccgctccccc cctcccgctg ccctcgggcc gggctgggtc     1200



gagctgcgat gccctcggac ttcatctcat tgctcagcgc ggacctagac ctggaatcgc     1260



ccaagtccct ctactcgcga gattctctga agttacaccc atcacagaat tttcatagag     1320



ctggactatt ggaagaatct gtctatgatc ttctcccaaa ggagttacag ttacctccat     1380



ctagagaaac atctgtagca tcaatgagtc agacaagcgg tggtgaggca ggctcgcctc     1440



ctccagctgt tgttgctgct ggatttgcct ctgaagcagg gagtgtctgc attaaaaatg     1500



acctgtagtt ctctgcttca tagatgcttc ttcagctccc tcctcttcct ccatgggcgg     1560



tgcttgcagc tcctttacca cctcttccag ccctaccatt tattctacct cagtcaccga     1620



cagcaaggct atgcaagtgg agagctgctc ctcagccgtg ggggtaagta acagaggggt     1680



aagtgaaaag cagttaacca gtaacacagt tcagcagcat ccatcaacac cgaagaggca     1740



cacagtcttg tacatctcac caccacctga ggacttgctg gataacagtc ggatgtcctg     1800



ccaggatgag gggtgtggat tggaatctga gcagagctgc agtatgtgga tggaggattc     1860



cccctccaac ttcagtaaca tgagcaccag ttcctacaat gataacactg aggtacctcg     1920



taaatcacga aaacgaaatc caaagcagag gccgggggtc aaacgacgag attgtgaaga     1980



atctaatatg gatatatttg atgccgacag tgccaaagca cctcactatg tgctttctca     2040



gcttaccacg gacaacaaag gcaactcaaa agcgggaaat ggaacattgg aaaaccaaaa     2100



aggaactgga gtaaagaaga gccctatgtt gtgtggacaa tatcctgtta aaagtgaggg     2160



aaaggagctg aagatagttg tacaacctga gacacagcac cgagctcggt acctgactga     2220



gggcagccgt ggctcagtga aagatagaac acagcaaggc tttcctacag taaagctgga     2280



aggccataat gaacctgtag tgttgcaagt gtttgtgggc aacgactctg gacgagtgaa     2340



accacatgga ttttatcagg cctgcagagt aactggacga aatacaactc cttgcaaaga     2400



agtggacatt gaaggcacta ctgttataga agtcggcctt gatcctagca acaacatgac     2460



actggcggtg gactgcgtag ggatattgaa attgaggaat gctgatgtcg aagccagaat     2520



aggaattgct ggttccaaga agaaaagcac tcgtgccaga ttggtttttc gagttaatat     2580



catgaggaaa gatggctcca ctttgacact gcaaacaccc tcttctccaa ttttgtgtac     2640



tcagccagca ggagtgccag aaatcttaaa gaaaagcttg catagctgtt cagtgaaagg     2700



agaagaagaa gtgtttttaa tcggcaagaa ctttctgaaa ggaactaaag ttattttcca     2760



agaaaatgtt tctgatgaaa actcttggaa gtcagaagct gaaattgata tggaactatt     2820



tcatcagaat catcttattg tgaaggttcc tccctatcat gaccaacata taactttgcc     2880



tgtgtcagtg ggaatatatg tagtgacaaa tgctggaaga tctcatgatg ttcaaccatt     2940



cacttacact ccagacccag cagcagctgg tgctttgaat gtaaatgtga agaaggaaat     3000



atctagtcca gcaagacctt gctcttttga agaggccatg aaagcaatga aaactactgg     3060



atgtaattta gataaggtaa atattatccc taatgccctg atgactccac tcataccaag     3120



cagtatgatt aagagtgaag atgttactcc aatggaagta acagcagaaa aaagatcttc     3180



cactattttt aagactacaa agtctgttgg atcaactcag caaacattag aaaacatctc     3240



aaacatagca ggaaatggct ctttttcatc accatcatct tcccacctac cttctgaaaa     3300



tgaaaaacag cagcagattc agcccaaggc atacaaccca gagaccctga caactattca     3360



aacccaggac atctcacagc ctggtacttt tccagcagtt tctgcttcta gtcagctgcc     3420



caacagcgat gcactattgc agcaggctac acagtttcag acaagagaaa ctcagtctag     3480



agagatatta cagtcagatg gtacagtggt taatttgtca caactgactg aggcatcaca     3540



acaacagcag cagtcaccac tacaagaaca agcacagact ttacagcagc agatttcatc     3600



aaatattttt ccatcaccaa atagtgtgag tcagcttcag aatactattc agcagctgca     3660



agcagggagt ttcacaggca gtactgctag tggcagcagt ggaagtgttg acttggtcca     3720



acaagtttta gaggcacagc agcagttatc ttcagtttta ttttctgctc cagatggtaa     3780



tgagaatgtt caagagcagc ttagtgcaga tatttttcaa caagtcagtc aaattcagag     3840



tggtgtaagc cctggaatgt tttcctcaac agagccaaca gtccatacca gaccagataa     3900



tttattacct ggaagagctg aaagtgttca tccacagtct gaaaacacgt tatctaatca     3960



acagcagcag cagcagcagc aacagcaagt gatggaatct tcagccgcaa tggtgatgga     4020



gatgcaacag agtatctgcc aggcagctgc ccagattcag tcagagttat tcccttcaac     4080



tgcttcagca aatggaaacc ttcagcaatc gccagtttac cagcagactt ctcacatgat     4140



gagtgcattg tctaccaatg aggatatgca aatgcagtgt gaattgtttt cttctcctcc     4200



tgcagtttct ggaaatgaaa cttctacaac taccacacag caggttgcaa cccctggcac     4260



taccatgttt cagacatcaa gttcaggaga tggagaagaa actggaacac aagcaaaaca     4320



gattcagaac agtgtctttc agaccatggt ccaaatgcaa catagtgggg acaatcaacc     4380



tcaagttaac cttttttcat ccacaaaaag tatgatgagt gttcagaata gtggtaccca     4440



acaacaaggt aatggtttat tccagcaagg gaatgagatg atgtcacttc aatctggaaa     4500



ttttttgcag cagtcttctc attcacaggc ccaacttttt catcctcaaa atcctattgc     4560



cgatgctcag aacctttccc aggaaactca aggttctctc tttcatagtc caaatcctat     4620



tgtccacagt cagacttcta caacctcctc tgaacaaatg cagcctccaa tgtttcactc     4680



tcaaagtacc attgctgtgt tacagggctc ttcagttcct caagaccagc agtcaaccaa     4740



catatttctt tcccagagtc ccatgaataa tcttcagact aacacagtag cccaagaagc     4800



attttttgca gcaccgaact caatttctcc acttcagtca acatcaaaca gtgaacaaca     4860



agctgctttc caacagcaag ctccaatatc acacatccag actcctatgc tttcccaaga     4920



acaggcacaa cccccgcagc agggtttatt tcagcctcag gtggccctgg gctcccttcc     4980



acctaatcca atgcctcaaa gccaacaagg aaccatgttc cagtcacagc actcaatagt     5040



tgccatgcag agtaactctc catcccagga acagcagcag cagcagcaac agcagcagca     5100



acagcagcag caacaacaac agagcatttt attcagtaat cagaatacca tggctacaat     5160



ggcgtctcca aagcaaccac caccaaacat gatattcaac ccaaatcaaa atccaatggc     5220



taatcaggag caacagaacc agtcaatttt tcaccaacaa agtaacatgg ccccaatgaa     5280



tcaagagcaa cagcccatgc aatttcagag tcagtccaca gtttcctcac ttcagaaccc     5340



aggtcctacc cagtcggaat catcacagac ccccttgttc catagctctc ctcagattca     5400



gttggtacaa gggtcaccta gttctcaaga gcagcaagta actctcttct tatctccagc     5460



atccatgtct gccttgcaga ccagtataaa tcaacaagat atgcaacagt ctcctcttta     5520



ttcccctcag aacaacatgc ctggaattca aggagccaca tcttcgcctc aaccacaggc     5580



tactttattt cacaacacag caggaggcac aatgaaccaa ctgcagaatt ctcctggctc     5640



atctcagcag acatcaggaa tgttcttatt tggcattcaa aataactgta gtcagctttt     5700



aacctctgga ccagctacat tgcctgatca gttgatggcc ataagtcagc caggccaacc     5760



acaaaacgag ggccagccac ctgtgacaac acttctttct cagcaaatgc cagagaattc     5820



tccactggca tcctctataa acaccaacca gaacatcgaa aagattgatt tgcttgtttc     5880



attgcaaaac caagggaaca acttgactgg ctccttttaa ctggatataa attccacgaa     5940



gaaaatcctg attccaagat gtcctgagat cttgtggttc catgagaatt attactttaa     6000



aaacaaaaca aaatataaaa aactgtgttt gagtaaactg atagatttta ctctgactgc     6060



aaaagagcac acctatgctg cttgttgcag taactaacca ccaatgttaa catcttcata     6120



ttttatattc ctaataacag tgatgactga gaatctattt gagtttccag ctggcagaat     6180



taattgttat tattttccta ggcgcaattt ccttaaacgt acagtttaaa ttcaaggctg     6240



gaccactcag ttattattgc tattagaaaa taatatatca tgtttacttt tgttcttcat     6300



tattttcttt cctgcattgt tttagtcaag taatggcttt tgaaaaagta aagttcaata     6360



ataactaagg ctgtgatttt tttcaatata aaaggcacag ctgttggcca aagtgaagga     6420



atcttttttc agttttattg gagaaactga agggtaacat tctaacaagt aaactgtatg     6480



tgcagataaa agtactcttg atttaacaca aaggcagatg atacacttat aaaactggga     6540



acagctggaa tgcttcttga ttttattttt tcagagagtt gttagttctc tgggtttcta     6600



ctaaggggtt tagccataac tgtgcataga aaaataatta tctgtaaaaa atgaagggga     6660



taatatatga taaattatgt tctgatatcc tcctacagta gtttaaattg acagaaaaat     6720



ttgaatgttt tcttcttaac ccagtcttag gctggtattc cctttttata tatatctata     6780



ttacttttca cctctttttc actttacttt agagaactat taatatacta ctggcttcat     6840



gaccctgtag catctttggc cactttaatc tagggtgacc tagcaatcct gcagcacagg     6900



gcagagagta ctgtcttagg aattattagg agttgattcc tgagaaacaa cacatttttc     6960



cccatgaacg gtgctgttct gaagtcttca aatttttccc tctaatagga aacagtataa     7020



attttaatta aaaaaaaaag gcaaactaaa atttcttgaa atatcacttc tccctgatct     7080



gcagtgagta taaattcact tgtcacctca gtgctttaca gtttgaagtg gtcacttacc     7140



tgatggttcc cacaagcctt aggctttaca gggttgtatc attgacttaa aatgaagaat     7200



taacttgtgt tacatctata aagagcaaaa taacacactc cagaacttgg cagttgtagc     7260



attagttata cagttttggg tgttcttgcc acccgtggga tgcctgcttc tcactaccac     7320



ctgtgtctgg acacatgctt atgtctcatt ttccttttgg catgtggaaa gctgtcaatg     7380



cagtgtaagg ccaacgtgtg tgtggcttct atgtgttgag ataatgtttt ggtatccttg     7440



tccgtttcat ttatttttta agtgtacaaa aaataacctg ttaattgttg aaggctactt     7500



ttctgttctt tttttttttt tttttctatc ctgtacattt agttgaactg tgcggaattg     7560



tggtgttggt tttgtttaca cagccagatt tttccttctt tttgttttgt gatgatcttc     7620



ctttgttctt tgaatgtgct cttttgtctt tttctctttt ttctcatgtt ttcttccctc     7680



cacctccacc cctttctttc tttctctctc tgattgagag gcattgaatt acgttttcag     7740



tagtacaggc ttcttgccga tatgaaggga acttttcaga aagagaccta ctctgggtca     7800



tttaattttg aatacagttt tcaatcgttc aagttttgga tggtttatat ctaatgtgtg     7860



tttcattttt ttggaaagct atattttgta tttaggaaat ggtatactat tttgctattt     7920



gtactgagtg agtacattgg cataaatata gaaatttata tatatacata tatataaact     7980



attctttttt gccacacatt tttgtggtaa atttgtgagt ttgtctgatg ttctaccaca     8040



acgtggcgtc tgataacagt gagggggggt ggggtttgtt atgtctttat tgagtattta     8100



agtatctttt gaaacaaatg acctgttcat ctgtggccat tccatcaggc agttagttcc     8160



ttgatgtcag tagtgggcta aaggcagctt actgtgtgtt tgctggagct ttcactcagc     8220



caagtgttag agtcaggaaa cccattgagg caatggcgtc aaatggtgtt tcacaagaat     8280



gagccattca gtctttgctc actatatatt taatatttta ttattgttgt tattgttatt     8340



attaattggc tttctgtatt ctatgccttt tatttataaa gacactaaga aaacccatgt     8400



ttgtaatttt aataacattt ttcccatctt gtaatatcca gagctacttt ataaattctc     8460



tgaaccaaaa gtattttcct cagtgtatct cttctccccc agcccctatt gggaaaaatt     8520



acccagtata gttcaggtta tgaggaggat cagccacaca atccagtgct tcagtttgaa     8580



aatgtaaaat tctaacccta aagtagggtt ggttgaaatt tcagacaaag caaacccagc     8640



aggtataaaa agtagtataa atacaaatct gtaagttatt tttgaatttt ctgaactttt     8700



ttctaagaga ttacatagga gactaaagaa atctatctgt tcaagttcta attaggatga     8760



ttgttaatac tgcactgtgg atgaagtggc gactggcttg tgtgctgact tctgtggttt     8820



agcaagaggt ttattgttat caaatgctaa ttggcaatgc caagtcactg ggaccaattt     8880



tctgttttat aatatctaag tttagaacag aatatatacc tgaactgtag tggtttgatc     8940



ggatggagac agaaaacccg atttttattc tcataaattt tgtggttatt tatacaaggg     9000



ctgtgctatg ctaccatatt cttgttcaat aataataggt ttgttgtttt ttttacattg     9060



ttaaatgttc cttaccccta aaggtcaatg ttaagtacaa cattctgaaa atacaatttg     9120



gctacgaaga gtattcatct tctttgaagc tcagtggttg atatttgtgc taataatgca     9180



atttcctgat tactgttaca agttatagct acatatggga gagactcagt gagccagcaa     9240



aggccataga aacaacaatt tattaaatgt atttatggca gaaggaccta aataaactgt     9300



gagccacctt ttcttcttta tattgttaca tttaagtgtt cttgctttca gcaactcaca     9360



ttaatgcttg gagcttatct ctttctctct ctctctctct ctctctgtgt gtgtgtgtgt     9420



atgtgtgtgt gtgtgtgtgt gtgtttcctt attgtcattc cattatatat ccacaccaac     9480



atgggtgacg ataattcaaa gtcatatttt gcctctaagc ttgatcatgt tacctttatg     9540



attaaagtat catgttattt agccaatgca aatctgtttt aaaacaaata gtttaaaaaa     9600



agaacaagtt tttaagggct ttattataga agaagtatta atgaaggact ttccttcctc     9660



cctccctttc ctcccctccc tgcctccctt cttcccttcc atctccccct cctccctgcc     9720



ttctttgttt ctccttccct tattcctccc tccctccttt ctcccttcct tcctttcttc     9780



cattcatcct tccttgcctt ttatttttat tttttgtaat atcacatgtg ctgtagtttg     9840



gaattttatt ctagtgcatt tcttgctcat cagaacctca gctaatctac ctaggaaaaa     9900



tagtatcaaa ggaaatgaga aagttgtatc tgagtccctc cagaactaag ataattcttt     9960



ttgaccattt aagcctttat aaatgcgttt tgaccattta agcctttata aatgcttgtt    10020



ttaggaaagt gaatctgtta gatgcatcaa caaataatga ccaggacaaa acgatttaat    10080



aattaaagtc tcaaatcacc atggttatac attttcacca gaaatagtaa tcttacaatt    10140



tttcattttt ctgatgaaga tttctgttcc aatatctgtt tcctaataga ttttttaaat    10200



taattagctt tcctctgctt tatgaccaca ggttttatcc ctaaccgaga cagctgtctt    10260



atatctgcat gccttagact gtgtggaggg actccatgaa gaaagaccat aggttagaaa    10320



aataactcat agtatatacc ctagtaagtg ggttagtaga atctcataac atgtattaaa    10380



aagaggtttt cttctctgct tgtttgtgtc actagagcaa aattgtagag ataatgctca    10440



taatgcagta aatatcagaa taatatctac aatatcattt gtggatggtc ccaggtccca    10500



gtgctctagt tactttactt cttttttttt ttttgagatg gagtcttgct ctgtctctca    10560



ggctagagca gtgtgcgatc tcagctcact gcagcctcca cctcccaggt tcaagcgatt    10620



ctcctgcctc agcctcccaa gtagccagga ttacaggcac cctccactag gcccggctaa    10680



ttttttttgt atttttttag tagagatggg gttttgccat gttggccagg ctggtttcga    10740



actcctaacc tccagtgatc cacctgcctc ggcgtcccaa agtgctagga ttacaggcat    10800



gagccaccac atccggccta attacttctt taatccccat ttatttttat gccattctag    10860



cctcatttat taataaaatt atgtttttac tttctctttc aggaaatttt ttaaattaat    10920



attttatatc tagatctaat gctatggaaa agtgcctttt tatcatttat aatttcattt    10980



ttcactattt ccaaaaacac ataaacaaat agtttcagta ggtcccagct tttacttttt    11040



ccatttaaac cttcttttct ccatttcttc cctttggctt aagaataaaa gaaaaggtac    11100



attgctagaa ttgtttcttt gggagagggt aaaagattac agaattagac tgttcagcct    11160



ttatataaac taaatttgtc ttcatctcaa ccagctaatg gtaggtctta tctgaatact    11220



catgagaatt ttagcatctg tgaaactcca tgcaccagat gtgtgtaaat ttcaggaaga    11280



aagtgttgaa agcattttct ctgatgttaa ttagatggaa ataaatcact aaaacatagt    11340



ttaggtaaag cctgattatg ccactttttt ttaactagac agggcaaagt tgtttatgtt    11400



agtgtacttc ttgtctatcc tcagttaatt tacctagaca aaaagtgtca aaggaaatga    11460



gaaaaaggtt atatctgact ccctccagac ctaagataat tccttttgat cagatacagt    11520



cagatggagt gccttggttt ttgttaattt tgcctctatt ccagctcctt accacagcgg    11580



tggtgcttaa agaaaggatc atcagcaaca ggtcaggata gttctacctt tgggataggg    11640



ctgctttccc cgtgctagta tttctgtgac tgttagtggc actgaggact gcaaactttt    11700



atgcaatatt cttaataccc tattgatatt atgcacttta atcattccaa agaagccaag    11760



aatgctgtat agtgatgatt ccttcctaat gaattcatct taactattta gaatgttatg    11820



tcccttttct tttggatagc caacttggta taaatgttat atggattttt ctaaaatgac    11880



tatataggac ttaagacttt gaaatgtaat ttacttataa ggggaaataa ttatgcttta    11940



gcacatcatt ttagaaacgt cacattttag aaacattcag cttgctaacc tacatgtttg    12000



ggaattcatt aaaaccagtt gtctatatat tttgtgccat gtatataaga acattacaat    12060



atatcttttt ctacatatgt agtatgtgca accagtggtt ctcagagtat ggttctcagc    12120



ccaccagcta gtatcagtat cacctgggaa ctagttagaa atgtaaattc tttggcccca    12180



tcccagacat actgagtcag aaactctgga atagggcccc cgcaatctgt tttcacaagc    12240



cctccaggtg attctgatgc acactttaaa gtttaggaac cactgggcta agactctgtt    12300



gagatataga gtttttcttc cactcagact gatatagtta tacattgttc ttcatgtaaa    12360



ttcagcttaa cctggttatc tataatcttt tattggcaaa agttaattct cagtactgcc    12420



tatagagata cagtgtattt tatgtacata cacaattagt ctaattcttg ataattcagt    12480



taatttagtt tggcattttc ctaccactta ctaaaaggtt tacattaaat gactgattta    12540



aatatatagg tgcaatgttc tatgtttatt ttaattgtta tgacatttaa gtagctaata    12600



taattgaccg gtgctaaagt ctcctgttta tccataaaat gggtacatta tgggcagtgt    12660



aatacaagct ttcttttcat tgcctagtac tttaccagca gaccacagtt ttgccctggc    12720



tagaccaacc ctcagaacaa aatcatcatt ccttgtattt atatttgtat ctgagatagt    12780



aaacaagatg gctggccagg tcaacatggc accttaactt atttttttaa taggtaaaac    12840



ttcttcaaaa gtagcttgct ttgtataaga actaagctat cagtatagat atagctatcc    12900



ttggagctta tgtttcagac aagaattatt tactaaaata aataataaac aagataatgc    12960



attatacaat ttgggcattt ctcgtttctc aagtgtatgc atcatggtaa atataaacta    13020



accacaagat aggtagattg attcatttca ttttaatctc cttgtgtaat tcagtacctc    13080



cataattgtt ctaatcttct tcccactgtt tacaaattac cagttaatta actcgtgaaa    13140



gaaaaattca catatcagaa taaaaataaa tgtatactca ctttataaaa atcaccactg    13200



ctgtctttcc ttaatactag cagtggaaat gtaagtggct tactctacaa attttggtgc    13260



tggcaaatac ataggcaaac tgttgggagc tgctctagtt acattcctcc cttcttattc    13320



cctttttctc ttcctcactt tattgcataa catattcctg tacccaaagc attctaccac    13380



agttctattt gactcccact tgtaataact cctttaaaaa attccatgtt taaccatatg    13440



accctgcttg cttactcata ttctccctcc ctctcccctt cctttctctc tcttccagaa    13500



gtcatttgcc tggtttgaaa tattttgtag ggattgctta ttatattatt ttagctgatg    13560



aacctcagga caacgtctac acacacacac atacatacac gcacacaaaa tctcagctgt    13620



tgaagagtgg gcttggaatc agacttctgt gtccagtaaa aaactcctgc actgaagtca    13680



ttgtgacttg agtagttaca gactgattcc agtgaacttg atctaatttc ttttgatcta    13740



atgaatgtgt ctgcttacct tgtttccttt taattgataa gctccaagta gttgctaatt    13800



ttttgacaac tttaaatgag tttcattcac ttcttttact taatgtttta agtatagtac    13860



caataatttc attaacctgt tctcaagtgg tttagctacc attctgccat ttttaatttt    13920



tatttaattt tatttgcttg agcacactga tcaaccactg aactgccttc ttccattgtc    13980



ctgcaatgat ataagggtta catttttgtg tatatggctt tcatagttgg gatttcagag    14040



cactgatacc agatattttc agtttgttct ctgggggaat ttcatttgca tctatgtttt    14100



tagctatctg tgataacttg ttaaatatta aaaagatatt ttgcttctat tggaacattt    14160



gtatactcgc aactatattt ctgtaaacag ctgcagtcaa aaataaaaca ctgaaagtta    14220



aaaaaaaaaa aaaaaaaaa                                                 14239





<210>  116

<211>  1455

<212>  PRT

<213>  Homo sapiens



<400>  116



Met Gly Gly Ala Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile 

1               5                   10                  15      





Tyr Ser Thr Ser Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys 

            20                  25                  30          





Ser Ser Ala Val Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu 

        35                  40                  45              





Thr Ser Asn Thr Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr 

    50                  55                  60                  





Val Leu Tyr Ile Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg 

65                  70                  75                  80  





Met Ser Cys Gln Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys 

                85                  90                  95      





Ser Met Trp Met Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr 

            100                 105                 110         





Ser Ser Tyr Asn Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg 

        115                 120                 125             





Asn Pro Lys Gln Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser 

    130                 135                 140                 





Asn Met Asp Ile Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val 

145                 150                 155                 160 





Leu Ser Gln Leu Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn 

                165                 170                 175     





Gly Thr Leu Glu Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met 

            180                 185                 190         





Leu Cys Gly Gln Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile 

        195                 200                 205             





Val Val Gln Pro Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly 

    210                 215                 220                 





Ser Arg Gly Ser Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val 

225                 230                 235                 240 





Lys Leu Glu Gly His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly 

                245                 250                 255     





Asn Asp Ser Gly Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg 

            260                 265                 270         





Val Thr Gly Arg Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly 

        275                 280                 285             





Thr Thr Val Ile Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu 

    290                 295                 300                 





Ala Val Asp Cys Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu 

305                 310                 315                 320 





Ala Arg Ile Gly Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg 

                325                 330                 335     





Leu Val Phe Arg Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr 

            340                 345                 350         





Leu Gln Thr Pro Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val 

        355                 360                 365             





Pro Glu Ile Leu Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu 

    370                 375                 380                 





Glu Glu Val Phe Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val 

385                 390                 395                 400 





Ile Phe Gln Glu Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala 

                405                 410                 415     





Glu Ile Asp Met Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val 

            420                 425                 430         





Pro Pro Tyr His Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile 

        435                 440                 445             





Tyr Val Val Thr Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr 

    450                 455                 460                 





Tyr Thr Pro Asp Pro Ala Ala Ala Gly Ala Leu Asn Val Asn Val Lys 

465                 470                 475                 480 





Lys Glu Ile Ser Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met 

                485                 490                 495     





Lys Ala Met Lys Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile 

            500                 505                 510         





Pro Asn Ala Leu Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser 

        515                 520                 525             





Glu Asp Val Thr Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr 

    530                 535                 540                 





Ile Phe Lys Thr Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu 

545                 550                 555                 560 





Asn Ile Ser Asn Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser 

                565                 570                 575     





Ser His Leu Pro Ser Glu Asn Glu Lys Gln Gln Gln Ile Gln Pro Lys 

            580                 585                 590         





Ala Tyr Asn Pro Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser 

        595                 600                 605             





Gln Pro Gly Thr Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn 

    610                 615                 620                 





Ser Asp Ala Leu Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr 

625                 630                 635                 640 





Gln Ser Arg Glu Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser 

                645                 650                 655     





Gln Leu Thr Glu Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu 

            660                 665                 670         





Gln Ala Gln Thr Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser 

        675                 680                 685             





Pro Asn Ser Val Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala 

    690                 695                 700                 





Gly Ser Phe Thr Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp 

705                 710                 715                 720 





Leu Val Gln Gln Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu 

                725                 730                 735     





Phe Ser Ala Pro Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala 

            740                 745                 750         





Asp Ile Phe Gln Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly 

        755                 760                 765             





Met Phe Ser Ser Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu 

    770                 775                 780                 





Leu Pro Gly Arg Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu 

785                 790                 795                 800 





Ser Asn Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser 

                805                 810                 815     





Ser Ala Ala Met Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala 

            820                 825                 830         





Ala Gln Ile Gln Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly 

        835                 840                 845             





Asn Leu Gln Gln Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser 

    850                 855                 860                 





Ala Leu Ser Thr Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser 

865                 870                 875                 880 





Ser Pro Pro Ala Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln 

                885                 890                 895     





Gln Val Ala Thr Pro Gly Thr Thr Met Phe Gln Thr Ser Ser Ser Gly 

            900                 905                 910         





Asp Gly Glu Glu Thr Gly Thr Gln Ala Lys Gln Ile Gln Asn Ser Val 

        915                 920                 925             





Phe Gln Thr Met Val Gln Met Gln His Ser Gly Asp Asn Gln Pro Gln 

    930                 935                 940                 





Val Asn Leu Phe Ser Ser Thr Lys Ser Met Met Ser Val Gln Asn Ser 

945                 950                 955                 960 





Gly Thr Gln Gln Gln Gly Asn Gly Leu Phe Gln Gln Gly Asn Glu Met 

                965                 970                 975     





Met Ser Leu Gln Ser Gly Asn Phe Leu Gln Gln Ser Ser His Ser Gln 

            980                 985                 990         





Ala Gln Leu Phe His Pro Gln Asn  Pro Ile Ala Asp Ala  Gln Asn Leu 

        995                 1000                 1005             





Ser Gln  Glu Thr Gln Gly Ser  Leu Phe His Ser Pro  Asn Pro Ile 

    1010                 1015                 1020             





Val His  Ser Gln Thr Ser Thr  Thr Ser Ser Glu Gln  Met Gln Pro 

    1025                 1030                 1035             





Pro Met  Phe His Ser Gln Ser  Thr Ile Ala Val Leu  Gln Gly Ser 

    1040                 1045                 1050             





Ser Val  Pro Gln Asp Gln Gln  Ser Thr Asn Ile Phe  Leu Ser Gln 

    1055                 1060                 1065             





Ser Pro  Met Asn Asn Leu Gln  Thr Asn Thr Val Ala  Gln Glu Ala 

    1070                 1075                 1080             





Phe Phe  Ala Ala Pro Asn Ser  Ile Ser Pro Leu Gln  Ser Thr Ser 

    1085                 1090                 1095             





Asn Ser  Glu Gln Gln Ala Ala  Phe Gln Gln Gln Ala  Pro Ile Ser 

    1100                 1105                 1110             





His Ile  Gln Thr Pro Met Leu  Ser Gln Glu Gln Ala  Gln Pro Pro 

    1115                 1120                 1125             





Gln Gln  Gly Leu Phe Gln Pro  Gln Val Ala Leu Gly  Ser Leu Pro 

    1130                 1135                 1140             





Pro Asn  Pro Met Pro Gln Ser  Gln Gln Gly Thr Met  Phe Gln Ser 

    1145                 1150                 1155             





Gln His  Ser Ile Val Ala Met  Gln Ser Asn Ser Pro  Ser Gln Glu 

    1160                 1165                 1170             





Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 

    1175                 1180                 1185             





Gln Gln  Ser Ile Leu Phe Ser  Asn Gln Asn Thr Met  Ala Thr Met 

    1190                 1195                 1200             





Ala Ser  Pro Lys Gln Pro Pro  Pro Asn Met Ile Phe  Asn Pro Asn 

    1205                 1210                 1215             





Gln Asn  Pro Met Ala Asn Gln  Glu Gln Gln Asn Gln  Ser Ile Phe 

    1220                 1225                 1230             





His Gln  Gln Ser Asn Met Ala  Pro Met Asn Gln Glu  Gln Gln Pro 

    1235                 1240                 1245             





Met Gln  Phe Gln Ser Gln Ser  Thr Val Ser Ser Leu  Gln Asn Pro 

    1250                 1255                 1260             





Gly Pro  Thr Gln Ser Glu Ser  Ser Gln Thr Pro Leu  Phe His Ser 

    1265                 1270                 1275             





Ser Pro  Gln Ile Gln Leu Val  Gln Gly Ser Pro Ser  Ser Gln Glu 

    1280                 1285                 1290             





Gln Gln  Val Thr Leu Phe Leu  Ser Pro Ala Ser Met  Ser Ala Leu 

    1295                 1300                 1305             





Gln Thr  Ser Ile Asn Gln Gln  Asp Met Gln Gln Ser  Pro Leu Tyr 

    1310                 1315                 1320             





Ser Pro  Gln Asn Asn Met Pro  Gly Ile Gln Gly Ala  Thr Ser Ser 

    1325                 1330                 1335             





Pro Gln  Pro Gln Ala Thr Leu  Phe His Asn Thr Ala  Gly Gly Thr 

    1340                 1345                 1350             





Met Asn  Gln Leu Gln Asn Ser  Pro Gly Ser Ser Gln  Gln Thr Ser 

    1355                 1360                 1365             





Gly Met  Phe Leu Phe Gly Ile  Gln Asn Asn Cys Ser  Gln Leu Leu 

    1370                 1375                 1380             





Thr Ser  Gly Pro Ala Thr Leu  Pro Asp Gln Leu Met  Ala Ile Ser 

    1385                 1390                 1395             





Gln Pro  Gly Gln Pro Gln Asn  Glu Gly Gln Pro Pro  Val Thr Thr 

    1400                 1405                 1410             





Leu Leu  Ser Gln Gln Met Pro  Glu Asn Ser Pro Leu  Ala Ser Ser 

    1415                 1420                 1425             





Ile Asn  Thr Asn Gln Asn Ile  Glu Lys Ile Asp Leu  Leu Val Ser 

    1430                 1435                 1440             





Leu Gln  Asn Gln Gly Asn Asn  Leu Thr Gly Ser Phe  

    1445                 1450                 1455 





<210>  117

<211>  42

<212>  PRT

<213>  Artificial sequece



<220>

<223>  A-beta 1-42 synthetic peptide



<400>  117



Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 

1               5                   10                  15      





Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 

            20                  25                  30          





Gly Leu Met Val Gly Gly Val Val Ile Ala 

        35                  40          





<210>  118

<211>  17

<212>  PRT

<213>  Artificial sequece



<220>

<223>  Ova peptide



<400>  118



Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly 

1               5                   10                  15      





Arg 

    





<210>  119

<211>  2217

<212>  DNA

<213>  Homo sapiens



<400>  119

ccccgccgcc gccgcccttc gcgccctggg ccatctccct cccacctccc tccgcggagc       60



agccagacag cgagggcccc ggccgggggc aggggggacg ccccgtccgg ggcacccccc      120



cggctctgag ccgcccgcgg ggccggcctc ggcccggagc ggaggaagga gtcgccgagg      180



agcagcctga ggccccagag tctgagacga gccgccgccg cccccgccac tgcggggagg      240



agggggagga ggagcgggag gagggacgag ctggtcggga gaagaggaaa aaaacttttg      300



agacttttcc gttgccgctg ggagccggag gcgcggggac ctcttggcgc gacgctgccc      360



cgcgaggagg caggacttgg ggaccccaga ccgcctccct ttgccgccgg ggacgcttgc      420



tccctccctg ccccctacac ggcgtccctc aggcgccccc attccggacc agccctcggg      480



agtcgccgac ccggcctccc gcaaagactt ttccccagac ctcgggcgca ccccctgcac      540



gccgccttca tccccggcct gtctcctgag cccccgcgca tcctagaccc tttctcctcc      600



aggagacgga tctctctccg acctgccaca gatcccctat tcaagaccac ccaccttctg      660



gtaccagatc gcgcccatct aggttatttc cgtgggatac tgagacaccc ccggtccaag      720



cctcccctcc accactgcgc ccttctccct gaggacctca gctttccctc gaggccctcc      780



taccttttgc cgggagaccc ccagcccctg caggggcggg gcctccccac cacaccagcc      840



ctgttcgcgc tctcggcagt gccggggggc gccgcctccc ccatgccgcc ctccgggctg      900



cggctgctgc cgctgctgct accgctgctg tggctactgg tgctgacgcc tggccggccg      960



gccgcgggac tatccacctg caagactatc gacatggagc tggtgaagcg gaagcgcatc     1020



gaggccatcc gcggccagat cctgtccaag ctgcggctcg ccagcccccc gagccagggg     1080



gaggtgccgc ccggcccgct gcccgaggcc gtgctcgccc tgtacaacag cacccgcgac     1140



cgggtggccg gggagagtgc agaaccggag cccgagcctg aggccgacta ctacgccaag     1200



gaggtcaccc gcgtgctaat ggtggaaacc cacaacgaaa tctatgacaa gttcaagcag     1260



agtacacaca gcatatatat gttcttcaac acatcagagc tccgagaagc ggtacctgaa     1320



cccgtgttgc tctcccgggc agagctgcgt ctgctgaggc tcaagttaaa agtggagcag     1380



cacgtggagc tgtaccagaa atacagcaac aattcctggc gatacctcag caaccggctg     1440



ctggcaccca gcgactcgcc agagtggtta tcttttgatg tcaccggagt tgtgcggcag     1500



tggttgagcc gtggagggga aattgagggc tttcgcctta gcgcccactg ctcctgtgac     1560



agcagggata acacactgca agtggacatc aacgggttca ctaccggccg ccgaggtgac     1620



ctggccacca ttcatggcat gaaccggcct ttcctgcttc tcatggccac cccgctggag     1680



agggcccagc atctgcaaag ctcccggcac cgccgagccc tggacaccaa ctattgcttc     1740



agctccacgg agaagaactg ctgcgtgcgg cagctgtaca ttgacttccg caaggacctc     1800



ggctggaagt ggatccacga gcccaagggc taccatgcca acttctgcct cgggccctgc     1860



ccctacattt ggagcctgga cacgcagtac agcaaggtcc tggccctgta caaccagcat     1920



aacccgggcg cctcggcggc gccgtgctgc gtgccgcagg cgctggagcc gctgcccatc     1980



gtgtactacg tgggccgcaa gcccaaggtg gagcagctgt ccaacatgat cgtgcgctcc     2040



tgcaagtgca gctgaggtcc cgccccgccc cgccccgccc cggcaggccc ggccccaccc     2100



cgccccgccc ccgctgcctt gcccatgggg gctgtattta aggacacccg tgccccaagc     2160



ccacctgggg ccccattaaa gatggagaga ggactgcgga aaaaaaaaaa aaaaaaa        2217





<210>  120

<211>  760

<212>  DNA

<213>  Homo sapiens



<400>  120

gaggaaccga gaggctgaga ctaacccaga aacatccaat tctcaaactg aagctcgcac       60



tctcgcctcc agcatgaaag tctctgccgc ccttctgtgc ctgctgctca tagcagccac      120



cttcattccc caagggctcg ctcagccaga tgcaatcaat gccccagtca cctgctgtta      180



taacttcacc aataggaaga tctcagtgca gaggctcgcg agctatagaa gaatcaccag      240



cagcaagtgt cccaaagaag ctgtgatctt caagaccatt gtggccaagg agatctgtgc      300



tgaccccaag cagaagtggg ttcaggattc catggaccac ctggacaagc aaacccaaac      360



tccgaagact tgaacactca ctccacaacc caagaatctg cagctaactt attttcccct      420



agctttcccc agacaccctg ttttatttta ttataatgaa ttttgtttgt tgatgtgaaa      480



cattatgcct taagtaatgt taattcttat ttaagttatt gatgttttaa gtttatcttt      540



catggtacta gtgtttttta gatacagaga cttggggaaa ttgcttttcc tcttgaacca      600



cagttctacc cctgggatgt tttgagggtc tttgcaagaa tcattaatac aaagaatttt      660



ttttaacatt ccaatgcatt gctaaaatat tattgtggaa atgaatattt tgtaactatt      720



acaccaaata aatatatttt tgtacaaaaa aaaaaaaaaa                            760





<210>  121

<211>  1052

<212>  DNA

<213>  Homo sapiens



<400>  121

agagagcgct gggagccgga ggggagcgca gcgagttttg gccagtggtc gtgcagtcca       60



aggggctgga tggcatgctg gacccaagct cagctcagcg tccggaccca ataacagttt      120



taccaaggga gcagctttct atcctggcca cactgaggtg catagcgtaa tgtccatgtt      180



gttctacact ctgatcacag cttttctgat cggcatacag gcggaaccac actcagagag      240



caatgtccct gcaggacaca ccatccccca agcccactgg actaaacttc agcattccct      300



tgacactgcc cttcgcagag cccgcagcgc cccggcagcg gcgatagctg cacgcgtggc      360



ggggcagacc cgcaacatta ctgtggaccc caggctgttt aaaaagcggc gactccgttc      420



accccgtgtg ctgtttagca cccagcctcc ccgtgaagct gcagacactc aggatctgga      480



cttcgaggtc ggtggtgctg cccccttcaa caggactcac aggagcaagc ggtcatcatc      540



ccatcccatc ttccacaggg gcgaattctc ggtgtgtgac agtgtcagcg tgtgggttgg      600



ggataagacc accgccacag acatcaaggg caaggaggtg atggtgttgg gagaggtgaa      660



cattaacaac agtgtattca aacagtactt ttttgagacc aagtgccggg acccaaatcc      720



cgttgacagc gggtgccggg gcattgactc aaagcactgg aactcatatt gtaccacgac      780



tcacaccttt gtcaaggcgc tgaccatgga tggcaagcag gctgcctggc ggtttatccg      840



gatagatacg gcctgtgtgt gtgtgctcag caggaaggct gtgagaagag cctgacctgc      900



cgacacgctc cctccccctg ccccttctac actctcctgg gcccctccct acctcaacct      960



gtaaattatt ttaaattata aggactgcat ggtaatttat agtttataca gttttaaaga     1020



atcattattt attaaatttt tggaagcata aa                                   1052





<210>  122

<211>  241

<212>  PRT

<213>  Homo sapiens



<400>  122



Met Ser Met Leu Phe Tyr Thr Leu Ile Thr Ala Phe Leu Ile Gly Ile 

1               5                   10                  15      





Gln Ala Glu Pro His Ser Glu Ser Asn Val Pro Ala Gly His Thr Ile 

            20                  25                  30          





Pro Gln Ala His Trp Thr Lys Leu Gln His Ser Leu Asp Thr Ala Leu 

        35                  40                  45              





Arg Arg Ala Arg Ser Ala Pro Ala Ala Ala Ile Ala Ala Arg Val Ala 

    50                  55                  60                  





Gly Gln Thr Arg Asn Ile Thr Val Asp Pro Arg Leu Phe Lys Lys Arg 

65                  70                  75                  80  





Arg Leu Arg Ser Pro Arg Val Leu Phe Ser Thr Gln Pro Pro Arg Glu 

                85                  90                  95      





Ala Ala Asp Thr Gln Asp Leu Asp Phe Glu Val Gly Gly Ala Ala Pro 

            100                 105                 110         





Phe Asn Arg Thr His Arg Ser Lys Arg Ser Ser Ser His Pro Ile Phe 

        115                 120                 125             





His Arg Gly Glu Phe Ser Val Cys Asp Ser Val Ser Val Trp Val Gly 

    130                 135                 140                 





Asp Lys Thr Thr Ala Thr Asp Ile Lys Gly Lys Glu Val Met Val Leu 

145                 150                 155                 160 





Gly Glu Val Asn Ile Asn Asn Ser Val Phe Lys Gln Tyr Phe Phe Glu 

                165                 170                 175     





Thr Lys Cys Arg Asp Pro Asn Pro Val Asp Ser Gly Cys Arg Gly Ile 

            180                 185                 190         





Asp Ser Lys His Trp Asn Ser Tyr Cys Thr Thr Thr His Thr Phe Val 

        195                 200                 205             





Lys Ala Leu Thr Met Asp Gly Lys Gln Ala Ala Trp Arg Phe Ile Arg 

    210                 215                 220                 





Ile Asp Thr Ala Cys Val Cys Val Leu Ser Arg Lys Ala Val Arg Arg 

225                 230                 235                 240 





Ala 

    





<210>  123

<211>  1349

<212>  DNA

<213>  Homo sapiens



<400>  123

agttgaagct cctctccctt ccgaacagct ccgcgcaccg ccccgcgacg cagcccggcg       60



caactacttt cttctctctc ctttctttct tcctctcctt tttcccctgc tgggtagtgg      120



ctgcggcggg gtgggggaga ctttgaatga ccgagctcgc gtccaccttt ctcttcatgt      180



cgacgtccct ggaaacggcc acacggatgc catggttact tttgccacga tcttacaggt      240



gaacaaggtg atgtccatct tgttttatgt gatatttctc gcttatctcc gtggcatcca      300



aggtaacaac atggatcaaa ggagtttgcc agaagactcg ctcaattccc tcattattaa      360



gctgatccag gcagatattt tgaaaaacaa gctctccaag cagatggtgg acgttaagga      420



aaattaccag agcaccctgc ccaaagctga ggctccccga gagccggagc ggggagggcc      480



cgccaagtca gcattccagc cggtgattgc aatggacacc gaactgctgc gacaacagag      540



acgctacaac tcaccgcggg tcctgctgag cgacagcacc cccttggagc ccccgccctt      600



gtatctcatg gaggattacg tgggcagccc cgtggtggcg aacagaacat cacggcggaa      660



acggtacgcg gagcataaga gtcaccgagg ggagtactcg gtatgtgaca gtgagagtct      720



gtgggtgacc gacaagtcat cggccatcga cattcgggga caccaggtca cggtgctggg      780



ggagatcaaa acgggcaact ctcccgtcaa acaatatttt tatgaaacgc gatgtaagga      840



agccaggccg gtcaaaaacg gttgcagggg tattgatgat aaacactgga actctcagtg      900



caaaacatcc caaacctacg tccgagcact gacttcagag aacaataaac tcgtgggctg      960



gcggtggata cggatagaca cgtcctgtgt gtgtgccttg tcgagaaaaa tcggaagaac     1020



atgaattggc atctctcccc atatataaat tattacttta aattatatga tatgcatgta     1080



gcatataaat gtttatattg tttttatata ttataagttg acctttattt attaaacttc     1140



agcaacccta cagtatataa gcttttttct caataaaatc agtgtgcttg ccttccctca     1200



ggcctctccc atctgttaaa acttgttttg tgatccggct ctcaggagtc actctgtaaa     1260



atctgtgtac accagtattt tgcattcagt attgtcaagg ccatgactgt tgttttagta     1320



aacttgttaa aatcaaaaaa aaaaaaaaa                                       1349





<210>  124

<211>  270

<212>  PRT

<213>  Homo sapiens



<400>  124



Met Val Thr Phe Ala Thr Ile Leu Gln Val Asn Lys Val Met Ser Ile 

1               5                   10                  15      





Leu Phe Tyr Val Ile Phe Leu Ala Tyr Leu Arg Gly Ile Gln Gly Asn 

            20                  25                  30          





Asn Met Asp Gln Arg Ser Leu Pro Glu Asp Ser Leu Asn Ser Leu Ile 

        35                  40                  45              





Ile Lys Leu Ile Gln Ala Asp Ile Leu Lys Asn Lys Leu Ser Lys Gln 

    50                  55                  60                  





Met Val Asp Val Lys Glu Asn Tyr Gln Ser Thr Leu Pro Lys Ala Glu 

65                  70                  75                  80  





Ala Pro Arg Glu Pro Glu Arg Gly Gly Pro Ala Lys Ser Ala Phe Gln 

                85                  90                  95      





Pro Val Ile Ala Met Asp Thr Glu Leu Leu Arg Gln Gln Arg Arg Tyr 

            100                 105                 110         





Asn Ser Pro Arg Val Leu Leu Ser Asp Ser Thr Pro Leu Glu Pro Pro 

        115                 120                 125             





Pro Leu Tyr Leu Met Glu Asp Tyr Val Gly Ser Pro Val Val Ala Asn 

    130                 135                 140                 





Arg Thr Ser Arg Arg Lys Arg Tyr Ala Glu His Lys Ser His Arg Gly 

145                 150                 155                 160 





Glu Tyr Ser Val Cys Asp Ser Glu Ser Leu Trp Val Thr Asp Lys Ser 

                165                 170                 175     





Ser Ala Ile Asp Ile Arg Gly His Gln Val Thr Val Leu Gly Glu Ile 

            180                 185                 190         





Lys Thr Gly Asn Ser Pro Val Lys Gln Tyr Phe Tyr Glu Thr Arg Cys 

        195                 200                 205             





Lys Glu Ala Arg Pro Val Lys Asn Gly Cys Arg Gly Ile Asp Asp Lys 

    210                 215                 220                 





His Trp Asn Ser Gln Cys Lys Thr Ser Gln Thr Tyr Val Arg Ala Leu 

225                 230                 235                 240 





Thr Ser Glu Asn Asn Lys Leu Val Gly Trp Arg Trp Ile Arg Ile Asp 

                245                 250                 255     





Thr Ser Cys Val Cys Ala Leu Ser Arg Lys Ile Gly Arg Thr 

            260                 265                 270 





<210>  125

<211>  1182

<212>  DNA

<213>  Homo sapiens



<400>  125

tgccagaata acacagactc agctgccaga gcctgctctt aacacctgtg tttccttttc       60



agatcttaca ggtgaacaag gtgatgtcca tcttgtttta tgtgatattt ctcgcttatc      120



tccgtggcat ccaaggtaac aacatggatc aaaggagttt gccagaagac tcgctcaatt      180



ccctcattat taagctgatc caggcagata ttttgaaaaa caagctctcc aagcagatgg      240



tggacgttaa ggaaaattac cagagcaccc tgcccaaagc tgaggctccc cgagagccgg      300



agcggggagg gcccgccaag tcagcattcc agccggtgat tgcaatggac accgaactgc      360



tgcgacaaca gagacgctac aactcaccgc gggtcctgct gagcgacagc acccccttgg      420



agcccccgcc cttgtatctc atggaggatt acgtgggcag ccccgtggtg gcgaacagaa      480



catcacggcg gaaacggtac gcggagcata agagtcaccg aggggagtac tcggtatgtg      540



acagtgagag tctgtgggtg accgacaagt catcggccat cgacattcgg ggacaccagg      600



tcacggtgct gggggagatc aaaacgggca actctcccgt caaacaatat ttttatgaaa      660



cgcgatgtaa ggaagccagg ccggtcaaaa acggttgcag gggtattgat gataaacact      720



ggaactctca gtgcaaaaca tcccaaacct acgtccgagc actgacttca gagaacaata      780



aactcgtggg ctggcggtgg atacggatag acacgtcctg tgtgtgtgcc ttgtcgagaa      840



aaatcggaag aacatgaatt ggcatctctc cccatatata aattattact ttaaattata      900



tgatatgcat gtagcatata aatgtttata ttgtttttat atattataag ttgaccttta      960



tttattaaac ttcagcaacc ctacagtata taagcttttt tctcaataaa atcagtgtgc     1020



ttgccttccc tcaggcctct cccatctgtt aaaacttgtt ttgtgatccg gctctcagga     1080



gtcactctgt aaaatctgtg tacaccagta ttttgcattc agtattgtca aggccatgac     1140



tgttgtttta gtaaacttgt taaaatcaaa aaaaaaaaaa aa                        1182





<210>  126

<211>  257

<212>  PRT

<213>  Homo sapiens



<400>  126



Met Ser Ile Leu Phe Tyr Val Ile Phe Leu Ala Tyr Leu Arg Gly Ile 

1               5                   10                  15      





Gln Gly Asn Asn Met Asp Gln Arg Ser Leu Pro Glu Asp Ser Leu Asn 

            20                  25                  30          





Ser Leu Ile Ile Lys Leu Ile Gln Ala Asp Ile Leu Lys Asn Lys Leu 

        35                  40                  45              





Ser Lys Gln Met Val Asp Val Lys Glu Asn Tyr Gln Ser Thr Leu Pro 

    50                  55                  60                  





Lys Ala Glu Ala Pro Arg Glu Pro Glu Arg Gly Gly Pro Ala Lys Ser 

65                  70                  75                  80  





Ala Phe Gln Pro Val Ile Ala Met Asp Thr Glu Leu Leu Arg Gln Gln 

                85                  90                  95      





Arg Arg Tyr Asn Ser Pro Arg Val Leu Leu Ser Asp Ser Thr Pro Leu 

            100                 105                 110         





Glu Pro Pro Pro Leu Tyr Leu Met Glu Asp Tyr Val Gly Ser Pro Val 

        115                 120                 125             





Val Ala Asn Arg Thr Ser Arg Arg Lys Arg Tyr Ala Glu His Lys Ser 

    130                 135                 140                 





His Arg Gly Glu Tyr Ser Val Cys Asp Ser Glu Ser Leu Trp Val Thr 

145                 150                 155                 160 





Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly His Gln Val Thr Val Leu 

                165                 170                 175     





Gly Glu Ile Lys Thr Gly Asn Ser Pro Val Lys Gln Tyr Phe Tyr Glu 

            180                 185                 190         





Thr Arg Cys Lys Glu Ala Arg Pro Val Lys Asn Gly Cys Arg Gly Ile 

        195                 200                 205             





Asp Asp Lys His Trp Asn Ser Gln Cys Lys Thr Ser Gln Thr Tyr Val 

    210                 215                 220                 





Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu Val Gly Trp Arg Trp Ile 

225                 230                 235                 240 





Arg Ile Asp Thr Ser Cys Val Cys Ala Leu Ser Arg Lys Ile Gly Arg 

                245                 250                 255     





Thr 

    





<210>  127

<211>  999

<212>  DNA

<213>  Homo sapiens



<400>  127

cctaggtggt tgccccctcc ctctcctgag atgtcaggaa ggagggggcc acctgtgtcc       60



tccacagggg ccccccgaag cctggggact cccagcccca gagctccgag gcggaggagg      120



tgctgacagg tgctccgaga gatgctccct ctcccctcat gctccctccc catcctcctc      180



cttttcctcc tccccagtgt gccaattgag tcccaacccc caccctcaac attgccccct      240



tttctggccc ctgagtggga ccttctctcc ccccgagtag tcctgtctag gggtgcccct      300



gctgggcccc ctctgctctt cctgctggag gctggggcct ttcgggagtc agcaggtgcc      360



ccggccaacc gcagccggcg tggggtgagc gaaactgcac cagcgagtcg tcggggtgag      420



ctggctgtgt gcgatgcagt cagtggctgg gtgacagacc gccggaccgc tgtggacttg      480



cgtgggcgcg aggtggaggt gttgggcgag gtgcctgcag ctggcggcag tcccctccgc      540



cagtacttct ttgaaacccg ctgcaaggct gataacgctg aggaaggtgg cccgggggca      600



ggtggagggg gctgccgggg agtggacagg aggcactggg tatctgagtg caaggccaag      660



cagtcctatg tgcgggcatt gaccgctgat gcccagggcc gtgtgggctg gcgatggatt      720



cgaattgaca ctgcctgcgt ctgcacactc ctcagccgga ctggccgggc ctgagaccca      780



tgcccaggaa aataacagag ctggatgctg agagacctca gggatggccc agctgatcta      840



aggaccccag tttgggaact catcaaataa tcacaaaatc acaattctct gattttgagc      900



tcaatctctg caggatgggt gaaaccacat ggggttttgg aggttgaata ggagttctcc      960



tggagcaact tgagggtaat aatgatgatg atataataa                             999





<210>  128

<211>  210

<212>  PRT

<213>  Homo sapiens



<400>  128



Met Leu Pro Leu Pro Ser Cys Ser Leu Pro Ile Leu Leu Leu Phe Leu 

1               5                   10                  15      





Leu Pro Ser Val Pro Ile Glu Ser Gln Pro Pro Pro Ser Thr Leu Pro 

            20                  25                  30          





Pro Phe Leu Ala Pro Glu Trp Asp Leu Leu Ser Pro Arg Val Val Leu 

        35                  40                  45              





Ser Arg Gly Ala Pro Ala Gly Pro Pro Leu Leu Phe Leu Leu Glu Ala 

    50                  55                  60                  





Gly Ala Phe Arg Glu Ser Ala Gly Ala Pro Ala Asn Arg Ser Arg Arg 

65                  70                  75                  80  





Gly Val Ser Glu Thr Ala Pro Ala Ser Arg Arg Gly Glu Leu Ala Val 

                85                  90                  95      





Cys Asp Ala Val Ser Gly Trp Val Thr Asp Arg Arg Thr Ala Val Asp 

            100                 105                 110         





Leu Arg Gly Arg Glu Val Glu Val Leu Gly Glu Val Pro Ala Ala Gly 

        115                 120                 125             





Gly Ser Pro Leu Arg Gln Tyr Phe Phe Glu Thr Arg Cys Lys Ala Asp 

    130                 135                 140                 





Asn Ala Glu Glu Gly Gly Pro Gly Ala Gly Gly Gly Gly Cys Arg Gly 

145                 150                 155                 160 





Val Asp Arg Arg His Trp Val Ser Glu Cys Lys Ala Lys Gln Ser Tyr 

                165                 170                 175     





Val Arg Ala Leu Thr Ala Asp Ala Gln Gly Arg Val Gly Trp Arg Trp 

            180                 185                 190         





Ile Arg Ile Asp Thr Ala Cys Val Cys Thr Leu Leu Ser Arg Thr Gly 

        195                 200                 205             





Arg Ala 

    210 





<210>  129

<211>  40

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  129

tccaccgcgg ccgcgccacc atgaccatcc ttttccttac                             40





<210>  130

<211>  37

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  130

ctatacggat ccaatccact atcttcccct tttaatg                                37





