                         SEQUENCE LISTING

<110>  Royal Nedalco B.V.
       C5 Yeast Company B.V.
 
<120>  Yeast strains engineered to produce ethanol and formate

<130>  P6031691PCT

<150>  EP10191736.7
<151>  2010-11-18

<150>  US61/415,054
<151>  2010-11-18

<150>  US61/471,836
<151>  2011-04-05

<160>  57    

<170>  PatentIn version 3.3

<210>  1
<211>  760
<212>  PRT
<213>  Escherichia coli

<400>  1

Met Ser Glu Leu Asn Glu Lys Leu Ala Thr Ala Trp Glu Gly Phe Thr 
1               5                   10                  15      


Lys Gly Asp Trp Gln Asn Glu Val Asn Val Arg Asp Phe Ile Gln Lys 
            20                  25                  30          


Asn Tyr Thr Pro Tyr Glu Gly Asp Glu Ser Phe Leu Ala Gly Ala Thr 
        35                  40                  45              


Glu Ala Thr Thr Thr Leu Trp Asp Lys Val Met Glu Gly Val Lys Leu 
    50                  55                  60                  


Glu Asn Arg Thr His Ala Pro Val Asp Phe Asp Thr Ala Val Ala Ser 
65                  70                  75                  80  


Thr Ile Thr Ser His Asp Ala Gly Tyr Ile Asn Lys Gln Leu Glu Lys 
                85                  90                  95      


Ile Val Gly Leu Gln Thr Glu Ala Pro Leu Lys Arg Ala Leu Ile Pro 
            100                 105                 110         


Phe Gly Gly Ile Lys Met Ile Glu Gly Ser Cys Lys Ala Tyr Asn Arg 
        115                 120                 125             


Glu Leu Asp Pro Met Ile Lys Lys Ile Phe Thr Glu Tyr Arg Lys Thr 
    130                 135                 140                 


His Asn Gln Gly Val Phe Asp Val Tyr Thr Pro Asp Ile Leu Arg Cys 
145                 150                 155                 160 


Arg Lys Ser Gly Val Leu Thr Gly Leu Pro Asp Ala Tyr Gly Arg Gly 
                165                 170                 175     


Arg Ile Ile Gly Asp Tyr Arg Arg Val Ala Leu Tyr Gly Ile Asp Tyr 
            180                 185                 190         


Leu Met Lys Asp Lys Leu Ala Gln Phe Thr Ser Leu Gln Ala Asp Leu 
        195                 200                 205             


Glu Asn Gly Val Asn Leu Glu Gln Thr Ile Arg Leu Arg Glu Glu Ile 
    210                 215                 220                 


Ala Glu Gln His Arg Ala Leu Gly Gln Met Lys Glu Met Ala Ala Lys 
225                 230                 235                 240 


Tyr Gly Tyr Asp Ile Ser Gly Pro Ala Thr Asn Ala Gln Glu Ala Ile 
                245                 250                 255     


Gln Trp Thr Tyr Phe Gly Tyr Leu Ala Ala Val Lys Ser Gln Asn Gly 
            260                 265                 270         


Ala Ala Met Ser Phe Gly Arg Thr Ser Thr Phe Leu Asp Val Tyr Ile 
        275                 280                 285             


Glu Arg Asp Leu Lys Ala Gly Lys Ile Thr Glu Gln Glu Ala Gln Glu 
    290                 295                 300                 


Met Val Asp His Leu Val Met Lys Leu Arg Met Val Arg Phe Leu Arg 
305                 310                 315                 320 


Thr Pro Glu Tyr Asp Glu Leu Phe Ser Gly Asp Pro Ile Trp Ala Thr 
                325                 330                 335     


Glu Ser Ile Gly Gly Met Gly Leu Asp Gly Arg Thr Leu Val Thr Lys 
            340                 345                 350         


Asn Ser Phe Arg Phe Leu Asn Thr Leu Tyr Thr Met Gly Pro Ser Pro 
        355                 360                 365             


Glu Pro Asn Met Thr Ile Leu Trp Ser Glu Lys Leu Pro Leu Asn Phe 
    370                 375                 380                 


Lys Lys Phe Ala Ala Lys Val Ser Ile Asp Thr Ser Ser Leu Gln Tyr 
385                 390                 395                 400 


Glu Asn Asp Asp Leu Met Arg Pro Asp Phe Asn Asn Asp Asp Tyr Ala 
                405                 410                 415     


Ile Ala Cys Cys Val Ser Pro Met Ile Val Gly Lys Gln Met Gln Phe 
            420                 425                 430         


Phe Gly Ala Arg Ala Asn Leu Ala Lys Thr Met Leu Tyr Ala Ile Asn 
        435                 440                 445             


Gly Gly Val Asp Glu Lys Leu Lys Met Gln Val Gly Pro Lys Ser Glu 
    450                 455                 460                 


Pro Ile Lys Gly Asp Val Leu Asn Tyr Asp Glu Val Met Glu Arg Met 
465                 470                 475                 480 


Asp His Phe Met Asp Trp Leu Ala Lys Gln Tyr Ile Thr Ala Leu Asn 
                485                 490                 495     


Ile Ile His Tyr Met His Asp Lys Tyr Ser Tyr Glu Ala Ser Leu Met 
            500                 505                 510         


Ala Leu His Asp Arg Asp Val Ile Arg Thr Met Ala Cys Gly Ile Ala 
        515                 520                 525             


Gly Leu Ser Val Ala Ala Asp Ser Leu Ser Ala Ile Lys Tyr Ala Lys 
    530                 535                 540                 


Val Lys Pro Ile Arg Asp Glu Asp Gly Leu Ala Ile Asp Phe Glu Ile 
545                 550                 555                 560 


Glu Gly Glu Tyr Pro Gln Phe Gly Asn Asn Asp Pro Arg Val Asp Asp 
                565                 570                 575     


Leu Ala Val Asp Leu Val Glu Arg Phe Met Lys Lys Ile Gln Lys Leu 
            580                 585                 590         


His Thr Tyr Arg Asp Ala Ile Pro Thr Gln Ser Val Leu Thr Ile Thr 
        595                 600                 605             


Ser Asn Val Val Tyr Gly Lys Lys Thr Gly Asn Thr Pro Asp Gly Arg 
    610                 615                 620                 


Arg Ala Gly Ala Pro Phe Gly Pro Gly Ala Asn Pro Met His Gly Arg 
625                 630                 635                 640 


Asp Gln Lys Gly Ala Val Ala Ser Leu Thr Ser Val Ala Lys Leu Pro 
                645                 650                 655     


Phe Ala Tyr Ala Lys Asp Gly Ile Ser Tyr Thr Phe Ser Ile Val Pro 
            660                 665                 670         


Asn Ala Leu Gly Lys Asp Asp Glu Val Arg Lys Thr Asn Leu Ala Gly 
        675                 680                 685             


Leu Met Asp Gly Tyr Phe His His Glu Ala Ser Ile Glu Gly Gly Gln 
    690                 695                 700                 


His Leu Asn Val Asn Val Met Asn Arg Glu Met Leu Leu Asp Ala Met 
705                 710                 715                 720 


Glu Asn Pro Glu Lys Tyr Pro Gln Leu Thr Ile Arg Val Ser Gly Tyr 
                725                 730                 735     


Ala Val Arg Phe Asn Ser Leu Thr Lys Glu Gln Gln Gln Asp Val Ile 
            740                 745                 750         


Thr Arg Thr Phe Thr Gln Ser Met 
        755                 760 


<210>  2
<211>  2283
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic codon optimised E.coli pflB

<400>  2
atgtctgaat tgaacgagaa gttggctacc gcttgggaag gtttcaccaa gggtgactgg     60

caaaacgaag ttaacgttag agacttcatc caaaagaact acaccccata cgaaggtgac    120

gaatctttct tggctggtgc taccgaagct accaccacct tgtgggacaa ggttatggaa    180

ggtgttaagt tggaaaacag aacccacgct ccagttgact tcgacaccgc tgttgcttct    240

accatcacct ctcacgacgc tggttacatc aacaagcaat tggaaaagat cgttggttta    300

caaaccgaag ctccattgaa gagagctttg atcccattcg gtggtatcaa gatgatcgaa    360

ggttcttgta aggcttacaa cagagaattg gacccaatga tcaagaagat tttcaccgaa    420

tacagaaaga cccacaacca aggtgttttc gacgtttaca ctccagacat cttgagatgt    480

agaaagtctg gtgttttgac tggtttgcca gacgcttacg gtagaggtag aatcatcggt    540

gactacagaa gagttgcttt gtacggtatc gactacttga tgaaggacaa gttggctcaa    600

ttcacctctt tgcaagctga cttggaaaac ggtgttaact tggaacaaac catcagattg    660

agagaagaaa tcgctgaaca acacagagct ttgggtcaaa tgaaggaaat ggctgctaag    720

tacggttacg acatctctgg tccagctacc aacgctcaag aagctatcca atggacctac    780

ttcggttact tggctgctgt taagtctcaa aacggtgctg ctatgtcttt cggtaggacc    840

tctaccttct tggacgttta catcgaaaga gacttgaagg ctggtaagat caccgaacaa    900

gaagctcaag aaatggttga ccacttggtt atgaagttga gaatggttag attcttgaga    960

accccagaat acgacgaatt gttctctggt gacccaatct gggctaccga atctatcggt   1020

ggtatgggtt tggacggtag aaccttggtt accaagaact ctttcagatt cttgaacacc   1080

ttatacacca tgggtccatc tccagaacca aacatgacca tcttgtggtc tgaaaagtta   1140

ccattgaact tcaagaagtt cgctgctaag gtttctatcg acacctcttc tttgcaatac   1200

gaaaacgacg acttgatgag accagacttc aacaacgacg actacgctat cgcttgttgt   1260

gtttctccaa tgatcgttgg taagcaaatg caattcttcg gtgctagagc taacttggct   1320

aagaccatgt tgtacgctat caacggtggt gttgacgaaa agttgaagat gcaagttggt   1380

ccaaagtctg aaccaatcaa gggtgacgtt ttgaactacg acgaagttat ggaaagaatg   1440

gaccacttca tggactggtt ggctaagcaa tacatcaccg ctttgaacat catccactac   1500

atgcacgaca agtactctta cgaagcatca ttgatggctt tgcacgacag agacgtaatc   1560

agaaccatgg cttgtggtat cgctggtttg tctgttgctg ctgactcttt gtctgctatc   1620

aagtacgcta aggttaagcc aatcagagac gaagacggtt tggctatcga cttcgaaatc   1680

gaaggtgaat accctcaatt cggtaacaac gacccaagag ttgacgactt ggctgttgac   1740

ttggttgaaa gatttatgaa gaagatccaa aagttgcaca cctacagaga cgctatccca   1800

acccaatctg ttttgactat cacatctaac gttgtttacg gtaagaagac tggtaacacc   1860

ccagacggta gaagagctgg tgctccattc ggtccaggtg ctaacccaat gcacggtaga   1920

gaccaaaagg gtgctgtagc atctttgacc tctgttgcta agttgccatt cgcttacgct   1980

aaggacggta tctcttacac cttctctatc gttccaaacg ctttgggtaa ggacgatgaa   2040

gttagaaaga ccaacttggc tggtttgatg gacggttact tccaccacga agcatctatc   2100

gaaggtggtc aacacttgaa cgtaaatgtt atgaacagag aaatgttgtt ggacgctatg   2160

gaaaacccag aaaagtaccc acaattgacc atcagagttt ctggttacgc tgttagattc   2220

aactctttga ccaaggaaca acaacaagac gttatcacca gaaccttcac ccaatctatg   2280

taa                                                                 2283


<210>  3
<211>  246
<212>  PRT
<213>  Escherichia coli

<400>  3

Met Ser Val Ile Gly Arg Ile His Ser Phe Glu Ser Cys Gly Thr Val 
1               5                   10                  15      


Asp Gly Pro Gly Ile Arg Phe Ile Thr Phe Phe Gln Gly Cys Leu Met 
            20                  25                  30          


Arg Cys Leu Tyr Cys His Asn Arg Asp Thr Trp Asp Thr His Gly Gly 
        35                  40                  45              


Lys Glu Val Thr Val Glu Asp Leu Met Lys Glu Val Val Thr Tyr Arg 
    50                  55                  60                  


His Phe Met Asn Ala Ser Gly Gly Gly Val Thr Ala Ser Gly Gly Glu 
65                  70                  75                  80  


Ala Ile Leu Gln Ala Glu Phe Val Arg Asp Trp Phe Arg Ala Cys Lys 
                85                  90                  95      


Lys Glu Gly Ile His Thr Cys Leu Asp Thr Asn Gly Phe Val Arg Arg 
            100                 105                 110         


Tyr Asp Pro Val Ile Asp Glu Leu Leu Glu Val Thr Asp Leu Val Met 
        115                 120                 125             


Leu Asp Leu Lys Gln Met Asn Asp Glu Ile His Gln Asn Leu Val Gly 
    130                 135                 140                 


Val Ser Asn His Arg Thr Leu Glu Phe Ala Lys Tyr Leu Ala Asn Lys 
145                 150                 155                 160 


Asn Val Lys Val Trp Ile Arg Tyr Val Val Val Pro Gly Trp Ser Asp 
                165                 170                 175     


Asp Asp Asp Ser Ala His Arg Leu Gly Glu Phe Thr Arg Asp Met Gly 
            180                 185                 190         


Asn Val Glu Lys Ile Glu Leu Leu Pro Tyr His Glu Leu Gly Lys His 
        195                 200                 205             


Lys Trp Val Ala Met Gly Glu Glu Tyr Lys Leu Asp Gly Val Lys Pro 
    210                 215                 220                 


Pro Lys Lys Glu Thr Met Glu Arg Val Lys Gly Ile Leu Glu Gln Tyr 
225                 230                 235                 240 


Gly His Lys Val Met Phe 
                245     


<210>  4
<211>  741
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic codon optimised E.coli pflA

<400>  4
atgtctgtta tcggtagaat ccactctttc gaatcttgtg gtactgttga cggtccaggt     60

atcagattca tcaccttctt ccaaggttgt ttgatgagat gtttgtactg tcacaacaga    120

gacacctggg acacccacgg tggtaaggaa gttactgttg aagacttgat gaaggaagtt    180

gttacctaca gacactttat gaacgcttca ggaggtggtg ttaccgcttc tggtggtgaa    240

gctatcttgc aagctgaatt tgttagagac tggttcagag cttgtaagaa ggaaggtatc    300

cacacctgtt tggacaccaa cggtttcgtt agaagatacg acccagttat cgacgaattg    360

ttggaagtta ccgacttggt tatgttggac ttgaagcaaa tgaacgacga aatccaccaa    420

aacttggttg gtgtttctaa ccacagaacc ttggaatttg ctaagtactt ggctaacaag    480

aacgttaagg tttggatcag atacgttgtt gttccaggtt ggtctgacga cgacgactct    540

gctcacagat tgggtgagtt caccagagac atgggtaacg ttgaaaagat cgaattgttg    600

ccataccacg aattgggtaa gcacaagtgg gttgctatgg gtgaagaata caagttggac    660

ggtgttaagc caccaaagaa ggaaaccatg gaaagagtta agggtatctt ggaacaatac    720

ggtcacaagg ttatgttcta a                                              741


<210>  5
<211>  376
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  5

Met Ser Lys Gly Lys Val Leu Leu Val Leu Tyr Glu Gly Gly Lys His 
1               5                   10                  15      


Ala Glu Glu Gln Glu Lys Leu Leu Gly Cys Ile Glu Asn Glu Leu Gly 
            20                  25                  30          


Ile Arg Asn Phe Ile Glu Glu Gln Gly Tyr Glu Leu Val Thr Thr Ile 
        35                  40                  45              


Asp Lys Asp Pro Glu Pro Thr Ser Thr Val Asp Arg Glu Leu Lys Asp 
    50                  55                  60                  


Ala Glu Ile Val Ile Thr Thr Pro Phe Phe Pro Ala Tyr Ile Ser Arg 
65                  70                  75                  80  


Asn Arg Ile Ala Glu Ala Pro Asn Leu Lys Leu Cys Val Thr Ala Gly 
                85                  90                  95      


Val Gly Ser Asp His Val Asp Leu Glu Ala Ala Asn Glu Arg Lys Ile 
            100                 105                 110         


Thr Val Thr Glu Val Thr Gly Ser Asn Val Val Ser Val Ala Glu His 
        115                 120                 125             


Val Met Ala Thr Ile Leu Val Leu Ile Arg Asn Tyr Asn Gly Gly His 
    130                 135                 140                 


Gln Gln Ala Ile Asn Gly Glu Trp Asp Ile Ala Gly Val Ala Lys Asn 
145                 150                 155                 160 


Glu Tyr Asp Leu Glu Asp Lys Ile Ile Ser Thr Val Gly Ala Gly Arg 
                165                 170                 175     


Ile Gly Tyr Arg Val Leu Glu Arg Leu Val Ala Phe Asn Pro Lys Lys 
            180                 185                 190         


Leu Leu Tyr Tyr Asp Tyr Gln Glu Leu Pro Ala Glu Ala Ile Asn Arg 
        195                 200                 205             


Leu Asn Glu Ala Ser Lys Leu Phe Asn Gly Arg Gly Asp Ile Val Gln 
    210                 215                 220                 


Arg Val Glu Lys Leu Glu Asp Met Val Ala Gln Ser Asp Val Val Thr 
225                 230                 235                 240 


Ile Asn Cys Pro Leu His Lys Asp Ser Arg Gly Leu Phe Asn Lys Lys 
                245                 250                 255     


Leu Ile Ser His Met Lys Asp Gly Ala Tyr Leu Val Asn Thr Ala Arg 
            260                 265                 270         


Gly Ala Ile Cys Val Ala Glu Asp Val Ala Glu Ala Val Lys Ser Gly 
        275                 280                 285             


Lys Leu Ala Gly Tyr Gly Gly Asp Val Trp Asp Lys Gln Pro Ala Pro 
    290                 295                 300                 


Lys Asp His Pro Trp Arg Thr Met Asp Asn Lys Asp His Val Gly Asn 
305                 310                 315                 320 


Ala Met Thr Val His Ile Ser Gly Thr Ser Leu Asp Ala Gln Lys Arg 
                325                 330                 335     


Tyr Ala Gln Gly Val Lys Asn Ile Leu Asn Ser Tyr Phe Ser Lys Lys 
            340                 345                 350         


Phe Asp Tyr Arg Pro Gln Asp Ile Ile Val Gln Asn Gly Ser Tyr Ala 
        355                 360                 365             


Thr Arg Ala Tyr Gly Gln Lys Lys 
    370                 375     


<210>  6
<211>  376
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  6

Met Ser Lys Gly Lys Val Leu Leu Val Leu Tyr Glu Gly Gly Lys His 
1               5                   10                  15      


Ala Glu Glu Gln Glu Lys Leu Leu Gly Cys Ile Glu Asn Glu Leu Gly 
            20                  25                  30          


Ile Arg Asn Phe Ile Glu Glu Gln Gly Tyr Glu Leu Val Thr Thr Ile 
        35                  40                  45              


Asp Lys Asp Pro Glu Pro Thr Ser Thr Val Asp Arg Glu Leu Lys Asp 
    50                  55                  60                  


Ala Glu Ile Val Ile Thr Thr Pro Phe Phe Pro Ala Tyr Ile Ser Arg 
65                  70                  75                  80  


Asn Arg Ile Ala Glu Ala Pro Asn Leu Lys Leu Cys Val Thr Ala Gly 
                85                  90                  95      


Val Gly Ser Asp His Val Asp Leu Glu Ala Ala Asn Glu Arg Lys Ile 
            100                 105                 110         


Thr Val Thr Glu Val Thr Gly Ser Asn Val Val Ser Val Ala Glu His 
        115                 120                 125             


Val Met Ala Thr Ile Leu Val Leu Ile Arg Asn Tyr Asn Gly Gly His 
    130                 135                 140                 


Gln Gln Ala Ile Asn Gly Glu Trp Asp Ile Ala Gly Val Ala Lys Asn 
145                 150                 155                 160 


Glu Tyr Asp Leu Glu Asp Lys Ile Ile Ser Thr Val Gly Ala Gly Arg 
                165                 170                 175     


Ile Gly Tyr Arg Val Leu Glu Arg Leu Val Ala Phe Asn Pro Lys Lys 
            180                 185                 190         


Leu Leu Tyr Tyr Asp Tyr Gln Glu Leu Pro Ala Glu Ala Ile Asn Arg 
        195                 200                 205             


Leu Asn Glu Ala Ser Lys Leu Phe Asn Gly Arg Gly Asp Ile Val Gln 
    210                 215                 220                 


Arg Val Glu Lys Leu Glu Asp Met Val Ala Gln Ser Asp Val Val Thr 
225                 230                 235                 240 


Ile Asn Cys Pro Leu His Lys Asp Ser Arg Gly Leu Phe Asn Lys Lys 
                245                 250                 255     


Leu Ile Ser His Met Lys Asp Gly Ala Tyr Leu Val Asn Thr Ala Arg 
            260                 265                 270         


Gly Ala Ile Cys Val Ala Glu Asp Val Ala Glu Ala Val Lys Ser Gly 
        275                 280                 285             


Lys Leu Ala Gly Tyr Gly Gly Asp Val Trp Asp Lys Gln Pro Ala Pro 
    290                 295                 300                 


Lys Asp His Pro Trp Arg Thr Met Asp Asn Lys Asp His Val Gly Asn 
305                 310                 315                 320 


Ala Met Thr Val His Ile Ser Gly Thr Ser Leu Asp Ala Gln Lys Arg 
                325                 330                 335     


Tyr Ala Gln Gly Val Lys Asn Ile Leu Asn Ser Tyr Phe Ser Lys Lys 
            340                 345                 350         


Phe Asp Tyr Arg Pro Gln Asp Ile Ile Val Gln Asn Gly Ser Tyr Ala 
        355                 360                 365             


Thr Arg Ala Tyr Gly Gln Lys Lys 
    370                 375     


<210>  7
<211>  316
<212>  PRT
<213>  Escherichia coli

<400>  7

Met Ser Lys Arg Lys Val Ala Ile Ile Gly Ser Gly Asn Ile Gly Thr 
1               5                   10                  15      


Asp Leu Met Ile Lys Ile Leu Arg His Gly Gln His Leu Glu Met Ala 
            20                  25                  30          


Val Met Val Gly Ile Asp Pro Gln Ser Asp Gly Leu Ala Arg Ala Arg 
        35                  40                  45              


Arg Met Gly Val Ala Thr Thr His Glu Gly Val Ile Gly Leu Met Asn 
    50                  55                  60                  


Met Pro Glu Phe Ala Asp Ile Asp Ile Val Phe Asp Ala Thr Ser Ala 
65                  70                  75                  80  


Gly Ala His Val Lys Asn Asp Ala Ala Leu Arg Glu Ala Lys Pro Asp 
                85                  90                  95      


Ile Arg Leu Ile Asp Leu Thr Pro Ala Ala Ile Gly Pro Tyr Cys Val 
            100                 105                 110         


Pro Val Val Asn Leu Glu Ala Asn Val Asp Gln Leu Asn Val Asn Met 
        115                 120                 125             


Val Thr Cys Gly Gly Gln Ala Thr Ile Pro Met Val Ala Ala Val Ser 
    130                 135                 140                 


Arg Val Ala Arg Val His Tyr Ala Glu Ile Ile Ala Ser Ile Ala Ser 
145                 150                 155                 160 


Lys Ser Ala Gly Pro Gly Thr Arg Ala Asn Ile Asp Glu Phe Thr Glu 
                165                 170                 175     


Thr Thr Ser Arg Ala Ile Glu Val Val Gly Gly Ala Ala Lys Gly Lys 
            180                 185                 190         


Ala Ile Ile Val Leu Asn Pro Ala Glu Pro Pro Leu Met Met Arg Asp 
        195                 200                 205             


Thr Val Tyr Val Leu Ser Asp Glu Ala Ser Gln Asp Asp Ile Glu Ala 
    210                 215                 220                 


Ser Ile Asn Glu Met Ala Glu Ala Val Gln Ala Tyr Val Pro Gly Tyr 
225                 230                 235                 240 


Arg Leu Lys Gln Arg Val Gln Phe Glu Val Ile Pro Gln Asp Lys Pro 
                245                 250                 255     


Val Asn Leu Pro Gly Val Gly Gln Phe Ser Gly Leu Lys Thr Ala Val 
            260                 265                 270         


Trp Leu Glu Val Glu Gly Ala Ala His Tyr Leu Pro Ala Tyr Ala Gly 
        275                 280                 285             


Asn Leu Asp Ile Met Thr Ser Ser Ala Leu Ala Thr Ala Glu Lys Met 
    290                 295                 300                 


Ala Gln Ser Leu Ala Arg Lys Ala Gly Glu Ala Ala 
305                 310                 315     


<210>  8
<211>  968
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic codon optimised E.coli mhpF

<400>  8
ctgcagtcta gatgtctaag agaaaggttg ctatcatcgg ttctggtaac atcggtactg     60

acttgatgat caagatccta agacacggtc aacacttgga aatggctgtt atggttggta    120

tcgacccaca atctgacggt ttggctagag ctagaagaat gggtgttgct accacccacg    180

aaggtgttat cggtttgatg aacatgccag aattcgctga catcgacatc gttttcgacg    240

ctacctctgc tggtgctcac gttaagaacg acgctgcttt gagagaagct aagccagaca    300

tcagattgat cgacttgacc ccagctgcta tcggtccata ctgtgttcca gttgttaact    360

tggaagctaa cgttgaccaa ttaaacgtta acatggttac ctgtggtggt caagctacca    420

tcccaatggt tgctgctgtt tcaagagttg ctagagttca ctacgctgaa atcatcgctt    480

ctatcgcttc taagtctgct ggtccaggta ccagagctaa catcgacgaa ttcaccgaaa    540

ccacctctag ggctatcgaa gttgttggtg gtgctgctaa gggtaaggct atcatcgttt    600

tgaacccagc tgaaccacca ttgatgatga gagacaccgt ttacgttttg tctgacgaag    660

catctcaaga cgacatcgaa gcttcaatca acgaaatggc tgaagctgtt caagcatacg    720

ttccaggtta cagattgaag caaagagttc aattcgaagt tatcccacaa gacaagccag    780

ttaacttgcc aggtgttggt caattctctg gtttgaagac cgctgtttgg ttggaagttg    840

aaggtgctgc tcactacttg ccagcttacg ctggtaactt ggacattatg acctcttctg    900

ctttggctac cgctgaaaag atggctcaat ctttggctag aaaggctggt gaagctgctt    960

aagcgcgc                                                             968


<210>  9
<211>  891
<212>  PRT
<213>  Escherichia coli

<400>  9

Met Ala Val Thr Asn Val Ala Glu Leu Asn Ala Leu Val Glu Arg Val 
1               5                   10                  15      


Lys Lys Ala Gln Arg Glu Tyr Ala Ser Phe Thr Gln Glu Gln Val Asp 
            20                  25                  30          


Lys Ile Phe Arg Ala Ala Ala Leu Ala Ala Ala Asp Ala Arg Ile Pro 
        35                  40                  45              


Leu Ala Lys Met Ala Val Ala Glu Ser Gly Met Gly Ile Val Glu Asp 
    50                  55                  60                  


Lys Val Ile Lys Asn His Phe Ala Ser Glu Tyr Ile Tyr Asn Ala Tyr 
65                  70                  75                  80  


Lys Asp Glu Lys Thr Cys Gly Val Leu Ser Glu Asp Asp Thr Phe Gly 
                85                  90                  95      


Thr Ile Thr Ile Ala Glu Pro Ile Gly Ile Ile Cys Gly Ile Val Pro 
            100                 105                 110         


Thr Thr Asn Pro Thr Ser Thr Ala Ile Phe Lys Ser Leu Ile Ser Leu 
        115                 120                 125             


Lys Thr Arg Asn Ala Ile Ile Phe Ser Pro His Pro Arg Ala Lys Asp 
    130                 135                 140                 


Ala Thr Asn Lys Ala Ala Asp Ile Val Leu Gln Ala Ala Ile Ala Ala 
145                 150                 155                 160 


Gly Ala Pro Lys Asp Leu Ile Gly Trp Ile Asp Gln Pro Ser Val Glu 
                165                 170                 175     


Leu Ser Asn Ala Leu Met His His Pro Asp Ile Asn Leu Ile Leu Ala 
            180                 185                 190         


Thr Gly Gly Pro Gly Met Val Lys Ala Ala Tyr Ser Ser Gly Lys Pro 
        195                 200                 205             


Ala Ile Gly Val Gly Ala Gly Asn Thr Pro Val Val Ile Asp Glu Thr 
    210                 215                 220                 


Ala Asp Ile Lys Arg Ala Val Ala Ser Val Leu Met Ser Lys Thr Phe 
225                 230                 235                 240 


Asp Asn Gly Val Ile Cys Ala Ser Glu Gln Ser Val Val Val Val Asp 
                245                 250                 255     


Ser Val Tyr Asp Ala Val Arg Glu Arg Phe Ala Thr His Gly Gly Tyr 
            260                 265                 270         


Leu Leu Gln Gly Lys Glu Leu Lys Ala Val Gln Asp Val Ile Leu Lys 
        275                 280                 285             


Asn Gly Ala Leu Asn Ala Ala Ile Val Gly Gln Pro Ala Tyr Lys Ile 
    290                 295                 300                 


Ala Glu Leu Ala Gly Phe Ser Val Pro Glu Asn Thr Lys Ile Leu Ile 
305                 310                 315                 320 


Gly Glu Val Thr Val Val Asp Glu Ser Glu Pro Phe Ala His Glu Lys 
                325                 330                 335     


Leu Ser Pro Thr Leu Ala Met Tyr Arg Ala Lys Asp Phe Glu Asp Ala 
            340                 345                 350         


Val Glu Lys Ala Glu Lys Leu Val Ala Met Gly Gly Ile Gly His Thr 
        355                 360                 365             


Ser Cys Leu Tyr Thr Asp Gln Asp Asn Gln Pro Ala Arg Val Ser Tyr 
    370                 375                 380                 


Phe Gly Gln Lys Met Lys Thr Ala Arg Ile Leu Ile Asn Thr Pro Ala 
385                 390                 395                 400 


Ser Gln Gly Gly Ile Gly Asp Leu Tyr Asn Phe Lys Leu Ala Pro Ser 
                405                 410                 415     


Leu Thr Leu Gly Cys Gly Ser Trp Gly Gly Asn Ser Ile Ser Glu Asn 
            420                 425                 430         


Val Gly Pro Lys His Leu Ile Asn Lys Lys Thr Val Ala Lys Arg Ala 
        435                 440                 445             


Glu Asn Met Leu Trp His Lys Leu Pro Lys Ser Ile Tyr Phe Arg Arg 
    450                 455                 460                 


Gly Ser Leu Pro Ile Ala Leu Asp Glu Val Ile Thr Asp Gly His Lys 
465                 470                 475                 480 


Arg Ala Leu Ile Val Thr Asp Arg Phe Leu Phe Asn Asn Gly Tyr Ala 
                485                 490                 495     


Asp Gln Ile Thr Ser Val Leu Lys Ala Ala Gly Val Glu Thr Glu Val 
            500                 505                 510         


Phe Phe Glu Val Glu Ala Asp Pro Thr Leu Ser Ile Val Arg Lys Gly 
        515                 520                 525             


Ala Glu Leu Ala Asn Ser Phe Lys Pro Asp Val Ile Ile Ala Leu Gly 
    530                 535                 540                 


Gly Gly Ser Pro Met Asp Ala Ala Lys Ile Met Trp Val Met Tyr Glu 
545                 550                 555                 560 


His Pro Glu Thr His Phe Glu Glu Leu Ala Leu Arg Phe Met Asp Ile 
                565                 570                 575     


Arg Lys Arg Ile Tyr Lys Phe Pro Lys Met Gly Val Lys Ala Lys Met 
            580                 585                 590         


Ile Ala Val Thr Thr Thr Ser Gly Thr Gly Ser Glu Val Thr Pro Phe 
        595                 600                 605             


Ala Val Val Thr Asp Asp Ala Thr Gly Gln Lys Tyr Pro Leu Ala Asp 
    610                 615                 620                 


Tyr Ala Leu Thr Pro Asp Met Ala Ile Val Asp Ala Asn Leu Val Met 
625                 630                 635                 640 


Asp Met Pro Lys Ser Leu Cys Ala Phe Gly Gly Leu Asp Ala Val Thr 
                645                 650                 655     


His Ala Met Glu Ala Tyr Val Ser Val Leu Ala Ser Glu Phe Ser Asp 
            660                 665                 670         


Gly Gln Ala Leu Gln Ala Leu Lys Leu Leu Lys Glu Tyr Leu Pro Ala 
        675                 680                 685             


Ser Tyr His Glu Gly Ser Lys Asn Pro Val Ala Arg Glu Arg Val His 
    690                 695                 700                 


Ser Ala Ala Thr Ile Ala Gly Ile Ala Phe Ala Asn Ala Phe Leu Gly 
705                 710                 715                 720 


Val Cys His Ser Met Ala His Lys Leu Gly Ser Gln Phe His Ile Pro 
                725                 730                 735     


His Gly Leu Ala Asn Ala Leu Leu Ile Cys Asn Val Ile Arg Tyr Asn 
            740                 745                 750         


Ala Asn Asp Asn Pro Thr Lys Gln Thr Ala Phe Ser Gln Tyr Asp Arg 
        755                 760                 765             


Pro Gln Ala Arg Arg Arg Tyr Ala Glu Ile Ala Asp His Leu Gly Leu 
    770                 775                 780                 


Ser Ala Pro Gly Asp Arg Thr Ala Ala Lys Ile Glu Lys Leu Leu Ala 
785                 790                 795                 800 


Trp Leu Glu Thr Leu Lys Ala Glu Leu Gly Ile Pro Lys Ser Ile Arg 
                805                 810                 815     


Glu Ala Gly Val Gln Glu Ala Asp Phe Leu Ala Asn Val Asp Lys Leu 
            820                 825                 830         


Ser Glu Asp Ala Phe Asp Asp Gln Cys Thr Gly Ala Asn Pro Arg Tyr 
        835                 840                 845             


Pro Leu Ile Ser Glu Leu Lys Gln Ile Leu Leu Asp Thr Tyr Tyr Gly 
    850                 855                 860                 


Arg Asp Tyr Val Glu Gly Glu Thr Ala Ala Lys Lys Glu Ala Ala Pro 
865                 870                 875                 880 


Ala Lys Ala Glu Lys Lys Ala Lys Lys Ser Ala 
                885                 890     


<210>  10
<211>  2690
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic codon optimised E.coli adhE

<400>  10
tctagaaaat ggctgttacc aacgttgctg aattgaacgc tttggttgaa agggttaaga     60

aggctcaaag agaatacgct tctttcaccc aagaacaagt tgacaagatc ttcagagctg    120

ctgctttggc tgctgctgac gctagaatcc cattggctaa gatggctgtt gctgaatctg    180

gtatgggtat cgttgaagac aaggttatca agaaccactt cgcttctgaa tacatctaca    240

acgcttacaa ggacgaaaag acctgtggtg ttttgtcaga agacgacacc ttcggtacca    300

tcaccatcgc tgaaccaatc ggtatcatct gtggtatcgt tccaaccacc aacccaacct    360

ctaccgctat cttcaagtct ttgatctctt tgaagaccag aaacgctatc atcttctctc    420

cacacccaag agctaaagac gctaccaaca aggctgctga catcgttttg caagctgcta    480

tcgctgctgg tgctccaaag gacttgatcg gttggatcga ccaaccatct gttgaattgt    540

ctaacgcttt gatgcaccac ccagacatca acttgatctt ggctaccggt ggtccaggta    600

tggttaaggc tgcttactct tctggtaagc cagctatcgg tgttggtgct ggtaacaccc    660

cagttgttat cgacgaaacc gctgacatca agagagctgt tgcttctgtt ttgatgtcta    720

agaccttcga caacggtgtt atctgtgctt ctgaacaatc tgttgttgtt gttgactctg    780

tttacgacgc tgttagagaa agattcgcta cccacggtgg ttacttgttg caaggtaagg    840

aattgaaggc tgttcaagac gttatcttga agaacggtgc tttgaacgct gctatcgttg    900

gtcaaccagc ttacaagatc gctgaattag ctggtttctc tgttccagaa aacaccaaga    960

tcttgatcgg tgaagttacc gttgttgacg aatctgaacc attcgctcac gaaaagttgt   1020

ctccaacctt ggctatgtac agagctaagg acttcgaaga cgctgttgaa aaagctgaaa   1080

agttggttgc tatgggtggt attggtcaca cctcttgttt gtacaccgac caagacaacc   1140

aaccagctag agtttcttac ttcggtcaaa agatgaagac cgctagaatc ttgatcaaca   1200

ccccagcttc tcaaggtggt atcggtgact tgtacaactt caagttggct ccatctttga   1260

ccttgggttg tggttcttgg ggtggtaact ctatctctga aaacgttggt ccaaagcact   1320

tgatcaacaa gaagaccgtt gctaagagag ctgaaaacat gttgtggcac aagttgccaa   1380

aatctatcta cttcagaaga ggttctttgc caatcgcttt ggacgaagtt atcaccgacg   1440

gtcacaagag agctttgatc gttaccgaca gattcttgtt caacaacggt tacgctgacc   1500

aaatcacctc tgttttgaag gctgctggtg ttgaaaccga agttttcttc gaagttgaag   1560

ctgacccaac cttgtctatc gttagaaagg gtgctgaatt ggctaactct ttcaagccag   1620

acgttatcat cgctttgggt ggtggttctc caatggacgc tgctaagatc atgtgggtta   1680

tgtacgaaca cccagaaacc cacttcgaag aattggcttt gagattcatg gacatcagaa   1740

agagaatcta caagttccca aagatgggtg ttaaggctaa gatgatcgct gttaccacca   1800

cctctggtac cggttctgaa gttaccccat tcgctgttgt taccgacgac gctaccggtc   1860

aaaagtaccc attggctgac tacgctttga ccccagacat ggctatcgtt gacgctaact   1920

tggttatgga catgccaaag tctttgtgtg ctttcggtgg tttggacgct gttacccacg   1980

ctatggaagc ttacgtttct gttttggctt ctgaattctc tgacggtcaa gctttgcaag   2040

ctttgaagtt gttgaaggaa tacttgccag cttcttacca cgaaggttct aagaacccag   2100

ttgctagaga aagagttcac tctgctgcta ccatcgctgg tatcgctttc gctaacgctt   2160

tcttgggtgt ttgtcactct atggctcaca agttgggttc tcaattccac atcccacacg   2220

gtttggctaa cgctttgttg atctgtaacg ttatcagata caacgctaac gacaacccaa   2280

ccaagcaaac cgctttctct caatacgaca gaccacaagc tagaagaaga tacgctgaaa   2340

tcgctgacca cttgggtttg tctgctccag gtgacagaac cgctgcaaag atcgaaaagt   2400

tgttggcttg gttggaaacc ttgaaggctg aattgggtat cccaaagtct atcagagaag   2460

ctggtgttca agaagctgac ttcttggcta acgttgacaa gttgtctgaa gacgctttcg   2520

acgaccaatg taccggtgct aacccaagat acccattgat ctctgaattg aagcaaatct   2580

tgttggacac ctactacggt agagactacg ttgaaggtga aaccgctgct aagaaggaag   2640

ctgctccagc taaggctgaa aagaaggcta agaagtctgc ttagcttaag              2690


<210>  11
<211>  870
<212>  PRT
<213>  Entamoeba histolytica

<400>  11

Met Ser Thr Gln Gln Thr Met Thr Val Asp Glu His Ile Asn Gln Leu 
1               5                   10                  15      


Val Arg Lys Ala Gln Val Ala Leu Lys Glu Tyr Leu Lys Pro Glu Tyr 
            20                  25                  30          


Thr Gln Glu Lys Ile Asp Tyr Ile Val Lys Lys Ala Ser Val Ala Ala 
        35                  40                  45              


Leu Asp Gln His Cys Ala Leu Ala Ala Ala Ala Val Glu Glu Thr Gly 
    50                  55                  60                  


Arg Gly Ile Phe Glu Asp Lys Ala Thr Lys Asn Ile Phe Ala Cys Glu 
65                  70                  75                  80  


His Val Thr His Glu Met Arg His Ala Lys Thr Val Gly Ile Ile Asn 
                85                  90                  95      


Val Asp Pro Leu Tyr Gly Ile Thr Glu Ile Ala Glu Pro Val Gly Val 
            100                 105                 110         


Val Cys Gly Val Thr Pro Val Thr Asn Pro Thr Ser Thr Ala Ile Phe 
        115                 120                 125             


Lys Ser Leu Ile Ser Ile Lys Thr Arg Asn Pro Ile Val Phe Ser Phe 
    130                 135                 140                 


His Pro Ser Ala Leu Lys Cys Ser Ile Met Ala Ala Lys Ile Val Arg 
145                 150                 155                 160 


Asp Ala Ala Ile Ala Ala Gly Ala Pro Glu Asn Cys Ile Gln Trp Ile 
                165                 170                 175     


Glu Phe Gly Gly Ile Glu Ala Ser Asn Lys Leu Met Asn His Pro Gly 
            180                 185                 190         


Val Ala Thr Ile Leu Ala Thr Gly Gly Asn Ala Met Val Lys Ala Ala 
        195                 200                 205             


Tyr Ser Ser Gly Lys Pro Ala Leu Gly Val Gly Ala Gly Asn Val Pro 
    210                 215                 220                 


Thr Tyr Ile Glu Lys Thr Cys Asn Ile Lys Gln Ala Ala Asn Asp Val 
225                 230                 235                 240 


Val Met Ser Lys Ser Phe Asp Asn Gly Met Ile Cys Ala Ser Glu Gln 
                245                 250                 255     


Ala Ala Ile Ile Asp Lys Glu Ile Tyr Asp Gln Val Val Glu Glu Met 
            260                 265                 270         


Lys Thr Leu Gly Ala Tyr Phe Ile Asn Glu Glu Glu Lys Ala Lys Leu 
        275                 280                 285             


Glu Lys Phe Met Phe Gly Val Asn Ala Tyr Ser Ala Asp Val Asn Asn 
    290                 295                 300                 


Ala Arg Leu Asn Pro Lys Cys Pro Gly Met Ser Pro Gln Trp Phe Ala 
305                 310                 315                 320 


Glu Gln Val Gly Ile Lys Val Pro Glu Asp Cys Asn Ile Ile Cys Ala 
                325                 330                 335     


Val Cys Lys Glu Val Gly Pro Asn Glu Pro Leu Thr Arg Glu Lys Leu 
            340                 345                 350         


Ser Pro Val Leu Ala Ile Leu Lys Ala Glu Asn Thr Gln Asp Gly Ile 
        355                 360                 365             


Asp Lys Ala Glu Ala Met Val Glu Phe Asn Gly Arg Gly His Ser Ala 
    370                 375                 380                 


Ala Ile His Ser Asn Asp Lys Ala Val Val Glu Lys Tyr Ala Leu Thr 
385                 390                 395                 400 


Met Lys Ala Cys Arg Ile Leu His Asn Thr Pro Ser Ser Gln Gly Gly 
                405                 410                 415     


Ile Gly Ser Ile Tyr Asn Tyr Ile Trp Pro Ser Phe Thr Leu Gly Cys 
            420                 425                 430         


Gly Ser Tyr Gly Gly Asn Ser Val Ser Ala Asn Val Thr Tyr His Asn 
        435                 440                 445             


Leu Leu Asn Ile Lys Arg Leu Ala Asp Arg Arg Asn Asn Leu Gln Trp 
    450                 455                 460                 


Phe Arg Val Pro Pro Lys Ile Phe Phe Glu Pro His Ser Ile Arg Tyr 
465                 470                 475                 480 


Leu Ala Glu Leu Lys Glu Leu Ser Lys Ile Phe Ile Val Ser Asp Arg 
                485                 490                 495     


Met Met Tyr Lys Leu Gly Tyr Val Asp Arg Val Met Asp Val Leu Lys 
            500                 505                 510         


Arg Arg Ser Asn Glu Val Glu Ile Glu Ile Phe Ile Asp Val Glu Pro 
        515                 520                 525             


Asp Pro Ser Ile Gln Thr Val Gln Lys Gly Leu Ala Val Met Asn Thr 
    530                 535                 540                 


Phe Gly Pro Asp Asn Ile Ile Ala Ile Gly Gly Gly Ser Ala Met Asp 
545                 550                 555                 560 


Ala Ala Lys Ile Met Trp Leu Leu Tyr Glu His Pro Glu Ala Asp Phe 
                565                 570                 575     


Phe Ala Met Lys Gln Lys Phe Ile Asp Leu Arg Lys Arg Ala Phe Lys 
            580                 585                 590         


Phe Pro Thr Met Gly Lys Lys Ala Arg Leu Ile Cys Ile Pro Thr Thr 
        595                 600                 605             


Ser Gly Thr Gly Ser Glu Val Thr Pro Phe Ala Val Ile Ser Asp His 
    610                 615                 620                 


Glu Thr Gly Lys Lys Tyr Pro Leu Ala Asp Tyr Ser Leu Thr Pro Ser 
625                 630                 635                 640 


Val Ala Ile Val Asp Pro Met Phe Thr Met Ser Leu Pro Lys Arg Ala 
                645                 650                 655     


Ile Ala Asp Thr Gly Leu Asp Val Leu Val His Ala Thr Glu Ala Tyr 
            660                 665                 670         


Val Ser Val Met Ala Asn Glu Tyr Thr Asp Gly Leu Ala Arg Glu Ala 
        675                 680                 685             


Val Lys Leu Val Phe Glu Asn Leu Leu Lys Ser Tyr Asn Gly Asp Leu 
    690                 695                 700                 


Glu Ala Arg Glu Lys Met His Asn Ala Ala Thr Ile Ala Gly Met Ala 
705                 710                 715                 720 


Phe Ala Ser Ala Phe Leu Gly Met Asp His Ser Met Ala His Lys Val 
                725                 730                 735     


Gly Ala Ala Phe His Leu Pro His Gly Arg Cys Val Ala Val Leu Leu 
            740                 745                 750         


Pro His Val Ile Arg Tyr Asn Gly Gln Lys Pro Arg Lys Leu Ala Met 
        755                 760                 765             


Trp Pro Lys Tyr Asn Phe Tyr Lys Ala Asp Gln Arg Tyr Met Glu Leu 
    770                 775                 780                 


Ala Gln Met Val Gly Leu Lys Cys Asn Thr Pro Ala Glu Gly Val Glu 
785                 790                 795                 800 


Ala Phe Ala Lys Ala Cys Glu Glu Leu Met Lys Ala Thr Glu Thr Ile 
                805                 810                 815     


Thr Gly Phe Lys Lys Ala Asn Ile Asp Glu Ala Ala Trp Met Ser Lys 
            820                 825                 830         


Val Pro Glu Met Ala Leu Leu Ala Phe Glu Asp Gln Cys Ser Pro Ala 
        835                 840                 845             


Asn Pro Arg Val Pro Met Val Lys Asp Met Glu Lys Ile Leu Lys Ala 
    850                 855                 860                 


Ala Tyr Tyr Pro Ile Ala 
865                 870 


<210>  12
<211>  2627
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic codon optimised E.histolytica ADH2

<400>  12
tctagaaaat gtctacccaa caaaccatga ccgttgacga acacatcaac caattagtta     60

gaaaggctca agttgctttg aaggaatact tgaagccaga atacacccaa gaaaagatcg    120

actacatcgt taagaaggct tctgttgctg ctttggacca acactgtgct ttggctgctg    180

ctgctgttga agaaaccggt agaggtatct tcgaagacaa ggctaccaag aacatcttcg    240

cttgtgaaca cgttacccac gaaatgagac acgctaagac cgttggtatc atcaacgttg    300

acccattgta cggtatcacc gaaatcgctg aaccagttgg tgttgtttgt ggtgttaccc    360

cagttaccaa cccaacctct accgctatct tcaagtcttt gatctctatc aagaccagaa    420

acccaatcgt tttctctttc cacccatctg ctttgaagtg ttctattatg gctgctaaaa    480

tcgttagaga cgctgctatc gctgctggtg ctccagaaaa ctgtatccaa tggatcgaat    540

tcggtggtat cgaagcttct aacaagttga tgaaccaccc aggtgttgct actatcttgg    600

ctaccggtgg taacgctatg gttaaggctg catactcttc tggtaagcca gctttgggtg    660

ttggtgctgg taacgttcca acctacatcg aaaagacctg taacatcaag caagctgcta    720

acgacgttgt tatgtctaag tctttcgaca acggtatgat ctgtgcttct gaacaagctg    780

ctatcatcga caaggaaatc tacgaccaag ttgttgaaga aatgaagacc ttgggtgctt    840

acttcatcaa cgaagaagaa aaggctaagt tggaaaagtt catgttcggt gttaacgctt    900

actctgctga cgttaacaac gctagattga acccaaagtg tccaggtatg tctccacaat    960

ggttcgctga acaagttggt atcaaggtac cagaagactg taacatcatc tgtgctgttt   1020

gtaaggaagt tggtccaaac gaaccattga ccagagaaaa gttgtctcca gttttggcta   1080

tcttgaaagc tgaaaacacc caagacggta tcgacaaggc tgaagctatg gttgaattta   1140

acggtagagg tcactctgct gctatccact ctaacgacaa ggctgttgtt gaaaagtacg   1200

ctttgaccat gaaggcttgt agaatcttgc acaacacccc atcttctcaa ggtggtatcg   1260

gttctatcta caactacatc tggccatctt tcaccttggg ttgtggttct tacggtggta   1320

actctgtttc tgctaacgtt acctaccaca acttgttgaa catcaagaga ttggctgaca   1380

gaagaaacaa cttgcaatgg ttcagagttc caccaaagat cttcttcgaa ccacactcta   1440

tcagatactt ggctgaattg aaggaattgt ctaagatctt catcgtttct gacagaatga   1500

tgtacaagtt gggttacgtt gacagagtta tggacgtttt gaagagaaga tctaacgaag   1560

ttgaaatcga aatcttcatc gacgttgaac cagacccatc tatccaaacc gttcaaaagg   1620

gtttggctgt tatgaacacc ttcggtccag acaacatcat cgctatcggt ggtggttctg   1680

ctatggacgc tgctaagatc atgtggttgt tgtacgaaca cccagaagct gacttcttcg   1740

ctatgaagca aaagttcatc gacttgagaa agagagcttt caagttccca accatgggta   1800

agaaggctag attgatctgt atcccaacca cctctggtac cggttctgaa gttaccccat   1860

tcgctgttat ctctgaccac gaaaccggta agaagtaccc attggctgac tactctttga   1920

ccccatctgt tgctatcgtt gacccaatgt tcaccatgtc tttgccaaag agagctatcg   1980

ctgacaccgg tttggacgtt ttggttcacg ctaccgaagc ttacgtttct gttatggcta   2040

acgaatacac cgacggtttg gctagagaag ctgttaagtt ggtttttgaa aacttgttga   2100

agtcttacaa cggtgacttg gaagctagag aaaagatgca caacgctgct accatcgctg   2160

gtatggcttt cgcttctgct ttcttgggta tggaccactc tatggctcac aaggttggtg   2220

ctgctttcca cttgccacac ggtagatgtg ttgctgtttt gttgccacac gttatcagat   2280

acaacggtca aaagccaaga aagttggcta tgtggccaaa gtacaacttc tacaaggctg   2340

accaaagata catggaattg gctcaaatgg ttggtttgaa gtgtaacacc ccagctgaag   2400

gtgttgaagc tttcgctaag gcttgtgaag aattgatgaa ggctaccgaa accatcaccg   2460

gtttcaagaa ggctaacatc gacgaagctg cttggatgtc taaggttcca gaaatggctt   2520

tgttggcttt cgaagaccaa tgttctccag ctaacccaag agttccaatg gttaaggaca   2580

tggaaaagat cttgaaggct gcttactacc caatcgctta gcttaag                 2627


<210>  13
<211>  312
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  13

Met Pro Ala Thr Leu His Asp Ser Thr Lys Ile Leu Ser Leu Asn Thr 
1               5                   10                  15      


Gly Ala Gln Ile Pro Gln Ile Gly Leu Gly Thr Trp Gln Ser Lys Glu 
            20                  25                  30          


Asn Asp Ala Tyr Lys Ala Val Leu Thr Ala Leu Lys Asp Gly Tyr Arg 
        35                  40                  45              


His Ile Asp Thr Ala Ala Ile Tyr Arg Asn Glu Asp Gln Val Gly Gln 
    50                  55                  60                  


Ala Ile Lys Asp Ser Gly Val Pro Arg Glu Glu Ile Phe Val Thr Thr 
65                  70                  75                  80  


Lys Leu Trp Cys Thr Gln His His Glu Pro Glu Val Ala Leu Asp Gln 
                85                  90                  95      


Ser Leu Lys Arg Leu Gly Leu Asp Tyr Val Asp Leu Tyr Leu Met His 
            100                 105                 110         


Trp Pro Ala Arg Leu Asp Pro Ala Tyr Ile Lys Asn Glu Asp Ile Leu 
        115                 120                 125             


Ser Val Pro Thr Lys Lys Asp Gly Ser Arg Ala Val Asp Ile Thr Asn 
    130                 135                 140                 


Trp Asn Phe Ile Lys Thr Trp Glu Leu Met Gln Glu Leu Pro Lys Thr 
145                 150                 155                 160 


Gly Lys Thr Lys Ala Val Gly Val Ser Asn Phe Ser Ile Asn Asn Leu 
                165                 170                 175     


Lys Asp Leu Leu Ala Ser Gln Gly Asn Lys Leu Thr Pro Ala Ala Asn 
            180                 185                 190         


Gln Val Glu Ile His Pro Leu Leu Pro Gln Asp Glu Leu Ile Asn Phe 
        195                 200                 205             


Cys Lys Ser Lys Gly Ile Val Val Glu Ala Tyr Ser Pro Leu Gly Ser 
    210                 215                 220                 


Thr Asp Ala Pro Leu Leu Lys Glu Pro Val Ile Leu Glu Ile Ala Lys 
225                 230                 235                 240 


Lys Asn Asn Val Gln Pro Gly His Val Val Ile Ser Trp His Val Gln 
                245                 250                 255     


Arg Gly Tyr Val Val Leu Pro Lys Ser Val Asn Pro Asp Arg Ile Lys 
            260                 265                 270         


Thr Asn Arg Lys Ile Phe Thr Leu Ser Thr Glu Asp Phe Glu Ala Ile 
        275                 280                 285             


Asn Asn Ile Ser Lys Glu Lys Gly Glu Lys Arg Val Val His Pro Asn 
    290                 295                 300                 


Trp Ser Pro Phe Glu Val Phe Lys 
305                 310         


<210>  14
<211>  584
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  14

Met Ser Ala Lys Ser Phe Glu Val Thr Asp Pro Val Asn Ser Ser Leu 
1               5                   10                  15      


Lys Gly Phe Ala Leu Ala Asn Pro Ser Ile Thr Leu Val Pro Glu Glu 
            20                  25                  30          


Lys Ile Leu Phe Arg Lys Thr Asp Ser Asp Lys Ile Ala Leu Ile Ser 
        35                  40                  45              


Gly Gly Gly Ser Gly His Glu Pro Thr His Ala Gly Phe Ile Gly Lys 
    50                  55                  60                  


Gly Met Leu Ser Gly Ala Val Val Gly Glu Ile Phe Ala Ser Pro Ser 
65                  70                  75                  80  


Thr Lys Gln Ile Leu Asn Ala Ile Arg Leu Val Asn Glu Asn Ala Ser 
                85                  90                  95      


Gly Val Leu Leu Ile Val Lys Asn Tyr Thr Gly Asp Val Leu His Phe 
            100                 105                 110         


Gly Leu Ser Ala Glu Arg Ala Arg Ala Leu Gly Ile Asn Cys Arg Val 
        115                 120                 125             


Ala Val Ile Gly Asp Asp Val Ala Val Gly Arg Glu Lys Gly Gly Met 
    130                 135                 140                 


Val Gly Arg Arg Ala Leu Ala Gly Thr Val Leu Val His Lys Ile Val 
145                 150                 155                 160 


Gly Ala Phe Ala Glu Glu Tyr Ser Ser Lys Tyr Gly Leu Asp Gly Thr 
                165                 170                 175     


Ala Lys Val Ala Lys Ile Ile Asn Asp Asn Leu Val Thr Ile Gly Ser 
            180                 185                 190         


Ser Leu Asp His Cys Lys Val Pro Gly Arg Lys Phe Glu Ser Glu Leu 
        195                 200                 205             


Asn Glu Lys Gln Met Glu Leu Gly Met Gly Ile His Asn Glu Pro Gly 
    210                 215                 220                 


Val Lys Val Leu Asp Pro Ile Pro Ser Thr Glu Asp Leu Ile Ser Lys 
225                 230                 235                 240 


Tyr Met Leu Pro Lys Leu Leu Asp Pro Asn Asp Lys Asp Arg Ala Phe 
                245                 250                 255     


Val Lys Phe Asp Glu Asp Asp Glu Val Val Leu Leu Val Asn Asn Leu 
            260                 265                 270         


Gly Gly Val Ser Asn Phe Val Ile Ser Ser Ile Thr Ser Lys Thr Thr 
        275                 280                 285             


Asp Phe Leu Lys Glu Asn Tyr Asn Ile Thr Pro Val Gln Thr Ile Ala 
    290                 295                 300                 


Gly Thr Leu Met Thr Ser Phe Asn Gly Asn Gly Phe Ser Ile Thr Leu 
305                 310                 315                 320 


Leu Asn Ala Thr Lys Ala Thr Lys Ala Leu Gln Ser Asp Phe Glu Glu 
                325                 330                 335     


Ile Lys Ser Val Leu Asp Leu Leu Asn Ala Phe Thr Asn Ala Pro Gly 
            340                 345                 350         


Trp Pro Ile Ala Asp Phe Glu Lys Thr Ser Ala Pro Ser Val Asn Asp 
        355                 360                 365             


Asp Leu Leu His Asn Glu Val Thr Ala Lys Ala Val Gly Thr Tyr Asp 
    370                 375                 380                 


Phe Asp Lys Phe Ala Glu Trp Met Lys Ser Gly Ala Glu Gln Val Ile 
385                 390                 395                 400 


Lys Ser Glu Pro His Ile Thr Glu Leu Asp Asn Gln Val Gly Asp Gly 
                405                 410                 415     


Asp Cys Gly Tyr Thr Leu Val Ala Gly Val Lys Gly Ile Thr Glu Asn 
            420                 425                 430         


Leu Asp Lys Leu Ser Lys Asp Ser Leu Ser Gln Ala Val Ala Gln Ile 
        435                 440                 445             


Ser Asp Phe Ile Glu Gly Ser Met Gly Gly Thr Ser Gly Gly Leu Tyr 
    450                 455                 460                 


Ser Ile Leu Leu Ser Gly Phe Ser His Gly Leu Ile Gln Val Cys Lys 
465                 470                 475                 480 


Ser Lys Asp Glu Pro Val Thr Lys Glu Ile Val Ala Lys Ser Leu Gly 
                485                 490                 495     


Ile Ala Leu Asp Thr Leu Tyr Lys Tyr Thr Lys Ala Arg Lys Gly Ser 
            500                 505                 510         


Ser Thr Met Ile Asp Ala Leu Glu Pro Phe Val Lys Glu Phe Thr Ala 
        515                 520                 525             


Ser Lys Asp Phe Asn Lys Ala Val Lys Ala Ala Glu Glu Gly Ala Lys 
    530                 535                 540                 


Ser Thr Ala Thr Phe Glu Ala Lys Phe Gly Arg Ala Ser Tyr Val Gly 
545                 550                 555                 560 


Asp Ser Ser Gln Val Glu Asp Pro Gly Ala Val Gly Leu Cys Glu Phe 
                565                 570                 575     


Leu Lys Gly Val Gln Ser Ala Leu 
            580                 


<210>  15
<211>  591
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  15

Met Ser His Lys Gln Phe Lys Ser Asp Gly Asn Ile Val Thr Pro Tyr 
1               5                   10                  15      


Leu Leu Gly Leu Ala Arg Ser Asn Pro Gly Leu Thr Val Ile Lys His 
            20                  25                  30          


Asp Arg Val Val Phe Arg Thr Ala Ser Ala Pro Asn Ser Gly Asn Pro 
        35                  40                  45              


Pro Lys Val Ser Leu Val Ser Gly Gly Gly Ser Gly His Glu Pro Thr 
    50                  55                  60                  


His Ala Gly Phe Val Gly Glu Gly Ala Leu Asp Ala Ile Ala Ala Gly 
65                  70                  75                  80  


Ala Ile Phe Ala Ser Pro Ser Thr Lys Gln Ile Tyr Ser Ala Ile Lys 
                85                  90                  95      


Ala Val Glu Ser Pro Lys Gly Thr Leu Ile Ile Val Lys Asn Tyr Thr 
            100                 105                 110         


Gly Asp Ile Ile His Phe Gly Leu Ala Ala Glu Arg Ala Lys Ala Ala 
        115                 120                 125             


Gly Met Lys Val Glu Leu Val Ala Val Gly Asp Asp Val Ser Val Gly 
    130                 135                 140                 


Lys Lys Lys Gly Ser Leu Val Gly Arg Arg Gly Leu Gly Ala Thr Val 
145                 150                 155                 160 


Leu Val His Lys Ile Ala Gly Ala Ala Ala Ser His Gly Leu Glu Leu 
                165                 170                 175     


Ala Glu Val Ala Glu Val Ala Gln Ser Val Val Asp Asn Ser Val Thr 
            180                 185                 190         


Ile Ala Ala Ser Leu Asp His Cys Thr Val Pro Gly His Lys Pro Glu 
        195                 200                 205             


Ala Ile Leu Gly Glu Asn Glu Tyr Glu Ile Gly Met Gly Ile His Asn 
    210                 215                 220                 


Glu Ser Gly Thr Tyr Lys Ser Ser Pro Leu Pro Ser Ile Ser Glu Leu 
225                 230                 235                 240 


Val Ser Gln Met Leu Pro Leu Leu Leu Asp Glu Asp Glu Asp Arg Ser 
                245                 250                 255     


Tyr Val Lys Phe Glu Pro Lys Glu Asp Val Val Leu Met Val Asn Asn 
            260                 265                 270         


Met Gly Gly Met Ser Asn Leu Glu Leu Gly Tyr Ala Ala Glu Val Ile 
        275                 280                 285             


Ser Glu Gln Leu Ile Asp Lys Tyr Gln Ile Val Pro Lys Arg Thr Ile 
    290                 295                 300                 


Thr Gly Ala Phe Ile Thr Ala Leu Asn Gly Pro Gly Phe Gly Ile Thr 
305                 310                 315                 320 


Leu Met Asn Ala Ser Lys Ala Gly Gly Asp Ile Leu Lys Tyr Phe Asp 
                325                 330                 335     


Tyr Pro Thr Thr Ala Ser Gly Trp Asn Gln Met Tyr His Ser Ala Lys 
            340                 345                 350         


Asp Trp Glu Val Leu Ala Lys Gly Gln Val Pro Thr Ala Pro Ser Leu 
        355                 360                 365             


Lys Thr Leu Arg Asn Glu Lys Gly Ser Gly Val Lys Ala Asp Tyr Asp 
    370                 375                 380                 


Thr Phe Ala Lys Ile Leu Leu Ala Gly Ile Ala Lys Ile Asn Glu Val 
385                 390                 395                 400 


Glu Pro Lys Val Thr Trp Tyr Asp Thr Ile Ala Gly Asp Gly Asp Cys 
                405                 410                 415     


Gly Thr Thr Leu Val Ser Gly Gly Glu Ala Leu Glu Glu Ala Ile Lys 
            420                 425                 430         


Asn His Thr Leu Arg Leu Glu Asp Ala Ala Leu Gly Ile Glu Asp Ile 
        435                 440                 445             


Ala Tyr Met Val Glu Asp Ser Met Gly Gly Thr Ser Gly Gly Leu Tyr 
    450                 455                 460                 


Ser Ile Tyr Leu Ser Ala Leu Ala Gln Gly Val Arg Asp Ser Gly Asp 
465                 470                 475                 480 


Lys Glu Leu Thr Ala Glu Thr Phe Lys Lys Ala Ser Asn Val Ala Leu 
                485                 490                 495     


Asp Ala Leu Tyr Lys Tyr Thr Arg Ala Arg Pro Gly Tyr Arg Thr Leu 
            500                 505                 510         


Ile Asp Ala Leu Gln Pro Phe Val Glu Ala Leu Lys Ala Gly Lys Gly 
        515                 520                 525             


Pro Arg Ala Ala Ala Gln Ala Ala Tyr Asp Gly Ala Glu Lys Thr Arg 
    530                 535                 540                 


Lys Met Asp Ala Leu Val Gly Arg Ala Ser Tyr Val Ala Lys Glu Glu 
545                 550                 555                 560 


Leu Arg Lys Leu Asp Ser Glu Gly Gly Leu Pro Asp Pro Gly Ala Val 
                565                 570                 575     


Gly Leu Ala Ala Leu Leu Asp Gly Phe Val Thr Ala Ala Gly Tyr 
            580                 585                 590     


<210>  16
<211>  560
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  16

Met Ser Leu Ile Ser Ile Leu Ser Pro Leu Ile Thr Ser Glu Gly Leu 
1               5                   10                  15      


Asp Ser Arg Ile Lys Pro Ser Pro Lys Lys Asp Ala Ser Thr Thr Thr 
            20                  25                  30          


Lys Pro Ser Leu Trp Lys Thr Thr Glu Phe Lys Phe Tyr Tyr Ile Ala 
        35                  40                  45              


Phe Leu Val Val Val Pro Leu Met Phe Tyr Ala Gly Leu Gln Ala Ser 
    50                  55                  60                  


Ser Pro Glu Asn Pro Asn Tyr Ala Arg Tyr Glu Arg Leu Leu Ser Gln 
65                  70                  75                  80  


Gly Trp Leu Phe Gly Arg Lys Val Asp Asn Ser Asp Ser Gln Tyr Arg 
                85                  90                  95      


Phe Phe Arg Asp Asn Phe Ala Leu Leu Ser Val Leu Met Leu Val His 
            100                 105                 110         


Thr Ser Ile Lys Arg Ile Val Leu Tyr Ser Thr Asn Ile Thr Lys Leu 
        115                 120                 125             


Arg Phe Asp Leu Ile Phe Gly Leu Ile Phe Leu Val Ala Ala His Gly 
    130                 135                 140                 


Val Asn Ser Ile Arg Ile Leu Ala His Met Leu Ile Leu Tyr Ala Ile 
145                 150                 155                 160 


Ala His Val Leu Lys Asn Phe Arg Arg Ile Ala Thr Ile Ser Ile Trp 
                165                 170                 175     


Ile Tyr Gly Ile Ser Thr Leu Phe Ile Asn Asp Asn Phe Arg Ala Tyr 
            180                 185                 190         


Pro Phe Gly Asn Ile Cys Ser Phe Leu Ser Pro Leu Asp His Trp Tyr 
        195                 200                 205             


Arg Gly Ile Ile Pro Arg Trp Asp Val Phe Phe Asn Phe Thr Leu Leu 
    210                 215                 220                 


Arg Val Leu Ser Tyr Asn Leu Asp Phe Leu Glu Arg Trp Glu Asn Leu 
225                 230                 235                 240 


Gln Lys Lys Lys Ser Pro Ser Tyr Glu Ser Lys Glu Ala Lys Ser Ala 
                245                 250                 255     


Ile Leu Leu Asn Glu Arg Ala Arg Leu Thr Ala Ala His Pro Ile Gln 
            260                 265                 270         


Asp Tyr Ser Leu Met Asn Tyr Ile Ala Tyr Val Thr Tyr Thr Pro Leu 
        275                 280                 285             


Phe Ile Ala Gly Pro Ile Ile Thr Phe Asn Asp Tyr Val Tyr Gln Ser 
    290                 295                 300                 


Lys His Thr Leu Pro Ser Ile Asn Phe Lys Phe Ile Phe Tyr Tyr Ala 
305                 310                 315                 320 


Val Arg Phe Val Ile Ala Leu Leu Ser Met Glu Phe Ile Leu His Phe 
                325                 330                 335     


Leu His Val Val Ala Ile Ser Lys Thr Lys Ala Trp Glu Asn Asp Thr 
            340                 345                 350         


Pro Phe Gln Ile Ser Met Ile Gly Leu Phe Asn Leu Asn Ile Ile Trp 
        355                 360                 365             


Leu Lys Leu Leu Ile Pro Trp Arg Leu Phe Arg Leu Trp Ala Leu Leu 
    370                 375                 380                 


Asp Gly Ile Asp Thr Pro Glu Asn Met Ile Arg Cys Val Asp Asn Asn 
385                 390                 395                 400 


Tyr Ser Ser Leu Ala Phe Trp Arg Ala Trp His Arg Ser Tyr Asn Lys 
                405                 410                 415     


Trp Val Val Arg Tyr Ile Tyr Ile Pro Leu Gly Gly Ser Lys Asn Arg 
            420                 425                 430         


Val Leu Thr Ser Leu Ala Val Phe Ser Phe Val Ala Ile Trp His Asp 
        435                 440                 445             


Ile Glu Leu Lys Leu Leu Leu Trp Gly Trp Leu Ile Val Leu Phe Leu 
    450                 455                 460                 


Leu Pro Glu Ile Phe Ala Thr Gln Ile Phe Ser His Tyr Thr Asp Ala 
465                 470                 475                 480 


Val Trp Tyr Arg His Val Cys Ala Val Gly Ala Val Phe Asn Ile Trp 
                485                 490                 495     


Val Met Met Ile Ala Asn Leu Phe Gly Phe Cys Leu Gly Ser Asp Gly 
            500                 505                 510         


Thr Lys Lys Leu Leu Ser Asp Met Phe Cys Thr Val Ser Gly Phe Lys 
        515                 520                 525             


Phe Val Ile Leu Ala Ser Val Ser Leu Phe Ile Ala Val Gln Ile Met 
    530                 535                 540                 


Phe Glu Ile Arg Glu Glu Glu Lys Arg His Gly Ile Tyr Leu Lys Cys 
545                 550                 555                 560 


<210>  17
<211>  609
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  17

Met Ser Met Leu Arg Ile Trp Ser Cys Ile Val His Phe Phe Ser Val 
1               5                   10                  15      


Gln Ala Leu Asp Ser Arg Ile Lys Pro Asp Ile Glu Phe Lys Arg Arg 
            20                  25                  30          


Gln Arg Ile Phe Ile Asn Ser Ser Lys Glu Glu Asn Gly Ser Ser Ser 
        35                  40                  45              


Ser Ala Val Thr Val Thr Arg Asn Pro Val Leu Ser Ser Asn Ser Pro 
    50                  55                  60                  


Ser Pro Pro Leu Trp Asn Thr Trp Glu Phe Arg Leu Tyr Tyr Leu Ala 
65                  70                  75                  80  


Phe Thr Val Val Val Pro Phe Met Ile Lys Ala Ala Leu Ala Thr Ser 
                85                  90                  95      


Ser Glu Ser Asn Pro Asn Tyr Tyr Lys Phe Ser Gly Leu Leu Ala His 
            100                 105                 110         


Gly Trp Ile Leu Gly Arg Lys Val Asp Asn Ser Asp Pro Gln Tyr Arg 
        115                 120                 125             


Phe Phe Arg Ser Asn Phe Phe Leu Leu Ala Ile Leu Ile Leu Leu Gln 
    130                 135                 140                 


Ile Ile Leu Lys Lys Val Phe Val Lys Phe Ser Lys Ile Pro Lys Thr 
145                 150                 155                 160 


Lys Phe Asp Phe Ala Cys Gly Leu Val Phe Val Cys Phe Met Tyr Gly 
                165                 170                 175     


Ile Asn Ser Val Lys Leu Phe Thr His Ala Phe Ile Phe Phe Thr Leu 
            180                 185                 190         


Ala His Ser Leu Lys Arg Lys Arg Leu Ile Ala Ala Phe Ala Ile Trp 
        195                 200                 205             


Ser Tyr Gly Ile Phe Thr Leu Phe Ile Asn Gln Lys Met Lys Asn Leu 
    210                 215                 220                 


Pro Phe Asn Asn Ile Ala Ile Ile Leu Ser Pro Met Asp Gln Trp Tyr 
225                 230                 235                 240 


Lys Gly Ile Val Pro Arg Trp Asp Phe Phe Phe Asn Phe Thr Leu Leu 
                245                 250                 255     


Arg Leu Leu Ser Tyr Ser Met Asp Phe Leu Glu Arg Trp His Glu Gln 
            260                 265                 270         


Leu Ser Arg Gln Pro Ser Ile Asp Tyr Asp Asp Arg Arg Pro Glu Phe 
        275                 280                 285             


Arg Lys Ser Leu Ser Gly Ser Thr Leu Gln Thr Ile Tyr Glu Ser Gly 
    290                 295                 300                 


Lys Asn Val Leu Glu Glu Lys Glu Arg Leu Val Ala Glu His His Ile 
305                 310                 315                 320 


Gln Asp Tyr Asn Phe Ile Asn Phe Ile Ala Tyr Ile Thr Tyr Ala Pro 
                325                 330                 335     


Leu Phe Leu Val Gly Pro Ile Ile Thr Phe Asn Asp Tyr Leu Tyr Gln 
            340                 345                 350         


Ser Glu Asn Lys Leu Pro Ser Leu Thr Lys Lys Asn Ile Gly Phe Tyr 
        355                 360                 365             


Ala Leu Lys Val Phe Ser Ser Leu Leu Leu Met Glu Ile Ile Leu His 
    370                 375                 380                 


Tyr Ile Tyr Val Gly Ala Ile Ala Arg Thr Lys Ala Trp Asn Asn Asp 
385                 390                 395                 400 


Thr Pro Leu Gln Gln Ala Met Ile Ala Leu Phe Asn Leu Asn Ile Met 
                405                 410                 415     


Tyr Leu Lys Leu Leu Ile Pro Trp Arg Leu Phe Arg Leu Trp Ala Met 
            420                 425                 430         


Val Asp Gly Ile Asp Ala Pro Glu Asn Met Leu Arg Cys Val Asp Asn 
        435                 440                 445             


Asn Tyr Ser Thr Val Gly Phe Trp Arg Ala Trp His Thr Ser Phe Asn 
    450                 455                 460                 


Lys Trp Val Ile Arg Tyr Ile Tyr Val Pro Phe Gly Gly Ser Asn Asn 
465                 470                 475                 480 


Lys Ile Leu Thr Ser Phe Ala Val Phe Ser Phe Val Ala Ile Trp His 
                485                 490                 495     


Asp Ile Gln Leu Arg Val Leu Phe Trp Gly Trp Leu Thr Val Leu Leu 
            500                 505                 510         


Leu Leu Gly Glu Thr Tyr Ile Thr Asn Cys Phe Ser Arg Tyr Arg Phe 
        515                 520                 525             


Arg Ser Trp Tyr Arg Phe Val Cys Gly Ile Gly Ala Ala Ile Asn Ile 
    530                 535                 540                 


Cys Met Met Met Ile Ile Asn Val Tyr Gly Phe Cys Leu Gly Ala Glu 
545                 550                 555                 560 


Gly Thr Lys Leu Leu Leu Lys Gly Ile Phe Asn Asn Ser His Ser Pro 
                565                 570                 575     


Glu Phe Leu Thr Ala Val Met Val Ser Leu Phe Ile Ala Val Gln Val 
            580                 585                 590         


Met Phe Glu Ile Arg Glu Glu Glu Lys Arg His Gly Ile Asn Leu Lys 
        595                 600                 605             


Cys 
    


<210>  18
<211>  669
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  18

Met Ser Asn Pro Gln Lys Ala Leu Asn Asp Phe Leu Ser Ser Glu Ser 
1               5                   10                  15      


Val His Thr His Asp Ser Ser Arg Lys Gln Ser Asn Lys Gln Ser Ser 
            20                  25                  30          


Asp Glu Gly Arg Ser Ser Ser Gln Pro Ser His His His Ser Gly Gly 
        35                  40                  45              


Thr Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Ser Asn Asn 
    50                  55                  60                  


Asn Asn Asn Gly Asn Asp Gly Gly Asn Asp Asp Asp Tyr Asp Tyr Glu 
65                  70                  75                  80  


Met Gln Asp Tyr Arg Pro Ser Pro Gln Ser Ala Arg Pro Thr Pro Thr 
                85                  90                  95      


Tyr Val Pro Gln Tyr Ser Val Glu Ser Gly Thr Ala Phe Pro Ile Gln 
            100                 105                 110         


Glu Val Ile Pro Ser Ala Tyr Ile Asn Thr Gln Asp Ile Asn His Lys 
        115                 120                 125             


Asp Asn Gly Pro Pro Ser Ala Ser Ser Asn Arg Ala Phe Arg Pro Arg 
    130                 135                 140                 


Gly Gln Thr Thr Val Ser Ala Asn Val Leu Asn Ile Glu Asp Phe Tyr 
145                 150                 155                 160 


Lys Asn Ala Asp Asp Ala His Thr Ile Pro Glu Ser His Leu Ser Arg 
                165                 170                 175     


Arg Arg Ser Arg Ser Arg Ala Thr Ser Asn Ala Gly His Ser Ala Asn 
            180                 185                 190         


Thr Gly Ala Thr Asn Gly Arg Thr Thr Gly Ala Gln Thr Asn Met Glu 
        195                 200                 205             


Ser Asn Glu Ser Pro Arg Asn Val Pro Ile Met Val Lys Pro Lys Thr 
    210                 215                 220                 


Leu Tyr Gln Asn Pro Gln Thr Pro Thr Val Leu Pro Ser Thr Tyr His 
225                 230                 235                 240 


Pro Ile Asn Lys Trp Ser Ser Val Lys Asn Thr Tyr Leu Lys Glu Phe 
                245                 250                 255     


Leu Ala Glu Phe Met Gly Thr Met Val Met Ile Ile Phe Gly Ser Ala 
            260                 265                 270         


Val Val Cys Gln Val Asn Val Ala Gly Lys Ile Gln Gln Asp Asn Phe 
        275                 280                 285             


Asn Val Ala Leu Asp Asn Leu Asn Val Thr Gly Ser Ser Ala Glu Thr 
    290                 295                 300                 


Ile Asp Ala Met Lys Ser Leu Thr Ser Leu Val Ser Ser Val Ala Gly 
305                 310                 315                 320 


Gly Thr Phe Asp Asp Val Ala Leu Gly Trp Ala Ala Ala Val Val Met 
                325                 330                 335     


Gly Tyr Phe Cys Ala Gly Gly Ser Ala Ile Ser Gly Ala His Leu Asn 
            340                 345                 350         


Pro Ser Ile Thr Leu Ala Asn Leu Val Tyr Arg Gly Phe Pro Leu Lys 
        355                 360                 365             


Lys Val Pro Tyr Tyr Phe Ala Gly Gln Leu Ile Gly Ala Phe Thr Gly 
    370                 375                 380                 


Ala Leu Ile Leu Phe Ile Trp Tyr Lys Arg Val Leu Gln Glu Ala Tyr 
385                 390                 395                 400 


Ser Asp Trp Trp Met Asn Glu Ser Val Ala Gly Met Phe Cys Val Phe 
                405                 410                 415     


Pro Lys Pro Tyr Leu Ser Ser Gly Arg Gln Phe Phe Ser Glu Phe Leu 
            420                 425                 430         


Cys Gly Ala Met Leu Gln Ala Gly Thr Phe Ala Leu Thr Asp Pro Tyr 
        435                 440                 445             


Thr Cys Leu Ser Ser Asp Val Phe Pro Leu Met Met Phe Ile Leu Ile 
    450                 455                 460                 


Phe Ile Ile Asn Ala Ser Met Ala Tyr Gln Thr Gly Thr Ala Met Asn 
465                 470                 475                 480 


Leu Ala Arg Asp Leu Gly Pro Arg Leu Ala Leu Tyr Ala Val Gly Phe 
                485                 490                 495     


Asp His Lys Met Leu Trp Val His His His His Phe Phe Trp Val Pro 
            500                 505                 510         


Met Val Gly Pro Phe Ile Gly Ala Leu Met Gly Gly Leu Val Tyr Asp 
        515                 520                 525             


Val Cys Ile Tyr Gln Gly His Glu Ser Pro Val Asn Trp Ser Leu Pro 
    530                 535                 540                 


Val Tyr Lys Glu Met Ile Met Arg Ala Trp Phe Arg Arg Pro Gly Trp 
545                 550                 555                 560 


Lys Lys Arg Asn Arg Ala Arg Arg Thr Ser Asp Leu Ser Asp Phe Ser 
                565                 570                 575     


Tyr Asn Asn Asp Asp Asp Glu Glu Phe Gly Glu Arg Met Ala Leu Gln 
            580                 585                 590         


Lys Thr Lys Thr Lys Ser Ser Ile Ser Asp Asn Glu Asn Glu Ala Gly 
        595                 600                 605             


Glu Lys Lys Val Gln Phe Lys Ser Val Gln Arg Gly Lys Arg Thr Phe 
    610                 615                 620                 


Gly Gly Ile Pro Thr Ile Leu Glu Glu Glu Asp Ser Ile Glu Thr Ala 
625                 630                 635                 640 


Ser Leu Gly Ala Thr Thr Thr Asp Ser Ile Gly Leu Ser Asp Thr Ser 
                645                 650                 655     


Ser Glu Asp Ser His Tyr Gly Asn Ala Lys Lys Val Thr 
            660                 665                 


<210>  19
<211>  713
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  19

Met Ser Pro Ser Ala Val Gln Ser Ser Lys Leu Glu Glu Gln Ser Ser 
1               5                   10                  15      


Glu Ile Asp Lys Leu Lys Ala Lys Met Ser Gln Ser Ala Ala Thr Ala 
            20                  25                  30          


Gln Gln Lys Lys Glu His Glu Tyr Glu His Leu Thr Ser Val Lys Ile 
        35                  40                  45              


Val Pro Gln Arg Pro Ile Ser Asp Arg Leu Gln Pro Ala Ile Ala Thr 
    50                  55                  60                  


His Tyr Ser Pro His Leu Asp Gly Leu Gln Asp Tyr Gln Arg Leu His 
65                  70                  75                  80  


Lys Glu Ser Ile Glu Asp Pro Ala Lys Phe Phe Gly Ser Lys Ala Thr 
                85                  90                  95      


Gln Phe Leu Asn Trp Ser Lys Pro Phe Asp Lys Val Phe Ile Pro Asp 
            100                 105                 110         


Pro Lys Thr Gly Arg Pro Ser Phe Gln Asn Asn Ala Trp Phe Leu Asn 
        115                 120                 125             


Gly Gln Leu Asn Ala Cys Tyr Asn Cys Val Asp Arg His Ala Leu Lys 
    130                 135                 140                 


Thr Pro Asn Lys Lys Ala Ile Ile Phe Glu Gly Asp Glu Pro Gly Gln 
145                 150                 155                 160 


Gly Tyr Ser Ile Thr Tyr Lys Glu Leu Leu Glu Glu Val Cys Gln Val 
                165                 170                 175     


Ala Gln Val Leu Thr Tyr Ser Met Gly Val Arg Lys Gly Asp Thr Val 
            180                 185                 190         


Ala Val Tyr Met Pro Met Val Pro Glu Ala Ile Ile Thr Leu Leu Ala 
        195                 200                 205             


Ile Ser Arg Ile Gly Ala Ile His Ser Val Val Phe Ala Gly Phe Ser 
    210                 215                 220                 


Ser Asn Ser Leu Arg Asp Arg Ile Asn Asp Gly Asp Ser Lys Val Val 
225                 230                 235                 240 


Ile Thr Thr Asp Glu Ser Asn Arg Gly Gly Lys Val Ile Glu Thr Lys 
                245                 250                 255     


Arg Ile Val Asp Asp Ala Leu Arg Glu Thr Pro Gly Val Arg His Val 
            260                 265                 270         


Leu Val Tyr Arg Lys Thr Asn Asn Pro Ser Val Ala Phe His Ala Pro 
        275                 280                 285             


Arg Asp Leu Asp Trp Ala Thr Glu Lys Lys Lys Tyr Lys Thr Tyr Tyr 
    290                 295                 300                 


Pro Cys Thr Pro Val Asp Ser Glu Asp Pro Leu Phe Leu Leu Tyr Thr 
305                 310                 315                 320 


Ser Gly Ser Thr Gly Ala Pro Lys Gly Val Gln His Ser Thr Ala Gly 
                325                 330                 335     


Tyr Leu Leu Gly Ala Leu Leu Thr Met Arg Tyr Thr Phe Asp Thr His 
            340                 345                 350         


Gln Glu Asp Val Phe Phe Thr Ala Gly Asp Ile Gly Trp Ile Thr Gly 
        355                 360                 365             


His Thr Tyr Val Val Tyr Gly Pro Leu Leu Tyr Gly Cys Ala Thr Leu 
    370                 375                 380                 


Val Phe Glu Gly Thr Pro Ala Tyr Pro Asn Tyr Ser Arg Tyr Trp Asp 
385                 390                 395                 400 


Ile Ile Asp Glu His Lys Val Thr Gln Phe Tyr Val Ala Pro Thr Ala 
                405                 410                 415     


Leu Arg Leu Leu Lys Arg Ala Gly Asp Ser Tyr Ile Glu Asn His Ser 
            420                 425                 430         


Leu Lys Ser Leu Arg Cys Leu Gly Ser Val Gly Glu Pro Ile Ala Ala 
        435                 440                 445             


Glu Val Trp Glu Trp Tyr Ser Glu Lys Ile Gly Lys Asn Glu Ile Pro 
    450                 455                 460                 


Ile Val Asp Thr Tyr Trp Gln Thr Glu Ser Gly Ser His Leu Val Thr 
465                 470                 475                 480 


Pro Leu Ala Gly Gly Val Thr Pro Met Lys Pro Gly Ser Ala Ser Phe 
                485                 490                 495     


Pro Phe Phe Gly Ile Asp Ala Val Val Leu Asp Pro Asn Thr Gly Glu 
            500                 505                 510         


Glu Leu Asn Thr Ser His Ala Glu Gly Val Leu Ala Val Lys Ala Ala 
        515                 520                 525             


Trp Pro Ser Phe Ala Arg Thr Ile Trp Lys Asn His Asp Arg Tyr Leu 
    530                 535                 540                 


Asp Thr Tyr Leu Asn Pro Tyr Pro Gly Tyr Tyr Phe Thr Gly Asp Gly 
545                 550                 555                 560 


Ala Ala Lys Asp Lys Asp Gly Tyr Ile Trp Ile Leu Gly Arg Val Asp 
                565                 570                 575     


Asp Val Val Asn Val Ser Gly His Arg Leu Ser Thr Ala Glu Ile Glu 
            580                 585                 590         


Ala Ala Ile Ile Glu Asp Pro Ile Val Ala Glu Cys Ala Val Val Gly 
        595                 600                 605             


Phe Asn Asp Asp Leu Thr Gly Gln Ala Val Ala Ala Phe Val Val Leu 
    610                 615                 620                 


Lys Asn Lys Ser Ser Trp Ser Thr Ala Thr Asp Asp Glu Leu Gln Asp 
625                 630                 635                 640 


Ile Lys Lys His Leu Val Phe Thr Val Arg Lys Asp Ile Gly Pro Phe 
                645                 650                 655     


Ala Ala Pro Lys Leu Ile Ile Leu Val Asp Asp Leu Pro Lys Thr Arg 
            660                 665                 670         


Ser Gly Lys Ile Met Arg Arg Ile Leu Arg Lys Ile Leu Ala Gly Glu 
        675                 680                 685             


Ser Asp Gln Leu Gly Asp Val Ser Thr Leu Ser Asn Pro Gly Ile Val 
    690                 695                 700                 


Arg His Leu Ile Asp Ser Val Lys Leu 
705                 710             


<210>  20
<211>  683
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  20

Met Thr Ile Lys Glu His Lys Val Val Tyr Glu Ala His Asn Val Lys 
1               5                   10                  15      


Ala Leu Lys Ala Pro Gln His Phe Tyr Asn Ser Gln Pro Gly Lys Gly 
            20                  25                  30          


Tyr Val Thr Asp Met Gln His Tyr Gln Glu Met Tyr Gln Gln Ser Ile 
        35                  40                  45              


Asn Glu Pro Glu Lys Phe Phe Asp Lys Met Ala Lys Glu Tyr Leu His 
    50                  55                  60                  


Trp Asp Ala Pro Tyr Thr Lys Val Gln Ser Gly Ser Leu Asn Asn Gly 
65                  70                  75                  80  


Asp Val Ala Trp Phe Leu Asn Gly Lys Leu Asn Ala Ser Tyr Asn Cys 
                85                  90                  95      


Val Asp Arg His Ala Phe Ala Asn Pro Asp Lys Pro Ala Leu Ile Tyr 
            100                 105                 110         


Glu Ala Asp Asp Glu Ser Asp Asn Lys Ile Ile Thr Phe Gly Glu Leu 
        115                 120                 125             


Leu Arg Lys Val Ser Gln Ile Ala Gly Val Leu Lys Ser Trp Gly Val 
    130                 135                 140                 


Lys Lys Gly Asp Thr Val Ala Ile Tyr Leu Pro Met Ile Pro Glu Ala 
145                 150                 155                 160 


Val Ile Ala Met Leu Ala Val Ala Arg Ile Gly Ala Ile His Ser Val 
                165                 170                 175     


Val Phe Ala Gly Phe Ser Ala Gly Ser Leu Lys Asp Arg Val Val Asp 
            180                 185                 190         


Ala Asn Ser Lys Val Val Ile Thr Cys Asp Glu Gly Lys Arg Gly Gly 
        195                 200                 205             


Lys Thr Ile Asn Thr Lys Lys Ile Val Asp Glu Gly Leu Asn Gly Val 
    210                 215                 220                 


Asp Leu Val Ser Arg Ile Leu Val Phe Gln Arg Thr Gly Thr Glu Gly 
225                 230                 235                 240 


Ile Pro Met Lys Ala Gly Arg Asp Tyr Trp Trp His Glu Glu Ala Ala 
                245                 250                 255     


Lys Gln Arg Thr Tyr Leu Pro Pro Val Ser Cys Asp Ala Glu Asp Pro 
            260                 265                 270         


Leu Phe Leu Leu Tyr Thr Ser Gly Ser Thr Gly Ser Pro Lys Gly Val 
        275                 280                 285             


Val His Thr Thr Gly Gly Tyr Leu Leu Gly Ala Ala Leu Thr Thr Arg 
    290                 295                 300                 


Tyr Val Phe Asp Ile His Pro Glu Asp Val Leu Phe Thr Ala Gly Asp 
305                 310                 315                 320 


Val Gly Trp Ile Thr Gly His Thr Tyr Ala Leu Tyr Gly Pro Leu Thr 
                325                 330                 335     


Leu Gly Thr Ala Ser Ile Ile Phe Glu Ser Thr Pro Ala Tyr Pro Asp 
            340                 345                 350         


Tyr Gly Arg Tyr Trp Arg Ile Ile Gln Arg His Lys Ala Thr His Phe 
        355                 360                 365             


Tyr Val Ala Pro Thr Ala Leu Arg Leu Ile Lys Arg Val Gly Glu Ala 
    370                 375                 380                 


Glu Ile Ala Lys Tyr Asp Thr Ser Ser Leu Arg Val Leu Gly Ser Val 
385                 390                 395                 400 


Gly Glu Pro Ile Ser Pro Asp Leu Trp Glu Trp Tyr His Glu Lys Val 
                405                 410                 415     


Gly Asn Lys Asn Cys Val Ile Cys Asp Thr Met Trp Gln Thr Glu Ser 
            420                 425                 430         


Gly Ser His Leu Ile Ala Pro Leu Ala Gly Ala Val Pro Thr Lys Pro 
        435                 440                 445             


Gly Ser Ala Thr Val Pro Phe Phe Gly Ile Asn Ala Cys Ile Ile Asp 
    450                 455                 460                 


Pro Val Thr Gly Val Glu Leu Glu Gly Asn Asp Val Glu Gly Val Leu 
465                 470                 475                 480 


Ala Val Lys Ser Pro Trp Pro Ser Met Ala Arg Ser Val Trp Asn His 
                485                 490                 495     


His Asp Arg Tyr Met Asp Thr Tyr Leu Lys Pro Tyr Pro Gly His Tyr 
            500                 505                 510         


Phe Thr Gly Asp Gly Ala Gly Arg Asp His Asp Gly Tyr Tyr Trp Ile 
        515                 520                 525             


Arg Gly Arg Val Asp Asp Val Val Asn Val Ser Gly His Arg Leu Ser 
    530                 535                 540                 


Thr Ser Glu Ile Glu Ala Ser Ile Ser Asn His Glu Asn Val Ser Glu 
545                 550                 555                 560 


Ala Ala Val Val Gly Ile Pro Asp Glu Leu Thr Gly Gln Thr Val Val 
                565                 570                 575     


Ala Tyr Val Ser Leu Lys Asp Gly Tyr Leu Gln Asn Asn Ala Thr Glu 
            580                 585                 590         


Gly Asp Ala Glu His Ile Thr Pro Asp Asn Leu Arg Arg Glu Leu Ile 
        595                 600                 605             


Leu Gln Val Arg Gly Glu Ile Gly Pro Phe Ala Ser Pro Lys Thr Ile 
    610                 615                 620                 


Ile Leu Val Arg Asp Leu Pro Arg Thr Arg Ser Gly Lys Ile Met Arg 
625                 630                 635                 640 


Arg Val Leu Arg Lys Val Ala Ser Asn Glu Ala Glu Gln Leu Gly Asp 
                645                 650                 655     


Leu Thr Thr Leu Ala Asn Pro Glu Val Val Pro Ala Ile Ile Ser Ala 
            660                 665                 670         


Val Glu Asn Gln Phe Phe Ser Gln Lys Lys Lys 
        675                 680             


<210>  21
<211>  440
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  21

Met Leu Ala Val Arg Arg Leu Thr Arg Tyr Thr Phe Leu Lys Arg Thr 
1               5                   10                  15      


His Pro Val Leu Tyr Thr Arg Arg Ala Tyr Lys Ile Leu Pro Ser Arg 
            20                  25                  30          


Ser Thr Phe Leu Arg Arg Ser Leu Leu Gln Thr Gln Leu His Ser Lys 
        35                  40                  45              


Met Thr Ala His Thr Asn Ile Lys Gln His Lys His Cys His Glu Asp 
    50                  55                  60                  


His Pro Ile Arg Arg Ser Asp Ser Ala Val Ser Ile Val His Leu Lys 
65                  70                  75                  80  


Arg Ala Pro Phe Lys Val Thr Val Ile Gly Ser Gly Asn Trp Gly Thr 
                85                  90                  95      


Thr Ile Ala Lys Val Ile Ala Glu Asn Thr Glu Leu His Ser His Ile 
            100                 105                 110         


Phe Glu Pro Glu Val Arg Met Trp Val Phe Asp Glu Lys Ile Gly Asp 
        115                 120                 125             


Glu Asn Leu Thr Asp Ile Ile Asn Thr Arg His Gln Asn Val Lys Tyr 
    130                 135                 140                 


Leu Pro Asn Ile Asp Leu Pro His Asn Leu Val Ala Asp Pro Asp Leu 
145                 150                 155                 160 


Leu His Ser Ile Lys Gly Ala Asp Ile Leu Val Phe Asn Ile Pro His 
                165                 170                 175     


Gln Phe Leu Pro Asn Ile Val Lys Gln Leu Gln Gly His Val Ala Pro 
            180                 185                 190         


His Val Arg Ala Ile Ser Cys Leu Lys Gly Phe Glu Leu Gly Ser Lys 
        195                 200                 205             


Gly Val Gln Leu Leu Ser Ser Tyr Val Thr Asp Glu Leu Gly Ile Gln 
    210                 215                 220                 


Cys Gly Ala Leu Ser Gly Ala Asn Leu Ala Pro Glu Val Ala Lys Glu 
225                 230                 235                 240 


His Trp Ser Glu Thr Thr Val Ala Tyr Gln Leu Pro Lys Asp Tyr Gln 
                245                 250                 255     


Gly Asp Gly Lys Asp Val Asp His Lys Ile Leu Lys Leu Leu Phe His 
            260                 265                 270         


Arg Pro Tyr Phe His Val Asn Val Ile Asp Asp Val Ala Gly Ile Ser 
        275                 280                 285             


Ile Ala Gly Ala Leu Lys Asn Val Val Ala Leu Ala Cys Gly Phe Val 
    290                 295                 300                 


Glu Gly Met Gly Trp Gly Asn Asn Ala Ser Ala Ala Ile Gln Arg Leu 
305                 310                 315                 320 


Gly Leu Gly Glu Ile Ile Lys Phe Gly Arg Met Phe Phe Pro Glu Ser 
                325                 330                 335     


Lys Val Glu Thr Tyr Tyr Gln Glu Ser Ala Gly Val Ala Asp Leu Ile 
            340                 345                 350         


Thr Thr Cys Ser Gly Gly Arg Asn Val Lys Val Ala Thr Tyr Met Ala 
        355                 360                 365             


Lys Thr Gly Lys Ser Ala Leu Glu Ala Glu Lys Glu Leu Leu Asn Gly 
    370                 375                 380                 


Gln Ser Ala Gln Gly Ile Ile Thr Cys Arg Glu Val His Glu Trp Leu 
385                 390                 395                 400 


Gln Thr Cys Glu Leu Thr Gln Glu Phe Pro Leu Phe Glu Ala Val Tyr 
                405                 410                 415     


Gln Ile Val Tyr Asn Asn Val Arg Met Glu Asp Leu Pro Glu Met Ile 
            420                 425                 430         


Glu Glu Leu Asp Ile Asp Asp Glu 
        435                 440 


<210>  22
<211>  391
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  22

Met Ser Ala Ala Ala Asp Arg Leu Asn Leu Thr Ser Gly His Leu Asn 
1               5                   10                  15      


Ala Gly Arg Lys Arg Ser Ser Ser Ser Val Ser Leu Lys Ala Ala Glu 
            20                  25                  30          


Lys Pro Phe Lys Val Thr Val Ile Gly Ser Gly Asn Trp Gly Thr Thr 
        35                  40                  45              


Ile Ala Lys Val Val Ala Glu Asn Cys Lys Gly Tyr Pro Glu Val Phe 
    50                  55                  60                  


Ala Pro Ile Val Gln Met Trp Val Phe Glu Glu Glu Ile Asn Gly Glu 
65                  70                  75                  80  


Lys Leu Thr Glu Ile Ile Asn Thr Arg His Gln Asn Val Lys Tyr Leu 
                85                  90                  95      


Pro Gly Ile Thr Leu Pro Asp Asn Leu Val Ala Asn Pro Asp Leu Ile 
            100                 105                 110         


Asp Ser Val Lys Asp Val Asp Ile Ile Val Phe Asn Ile Pro His Gln 
        115                 120                 125             


Phe Leu Pro Arg Ile Cys Ser Gln Leu Lys Gly His Val Asp Ser His 
    130                 135                 140                 


Val Arg Ala Ile Ser Cys Leu Lys Gly Phe Glu Val Gly Ala Lys Gly 
145                 150                 155                 160 


Val Gln Leu Leu Ser Ser Tyr Ile Thr Glu Glu Leu Gly Ile Gln Cys 
                165                 170                 175     


Gly Ala Leu Ser Gly Ala Asn Ile Ala Thr Glu Val Ala Gln Glu His 
            180                 185                 190         


Trp Ser Glu Thr Thr Val Ala Tyr His Ile Pro Lys Asp Phe Arg Gly 
        195                 200                 205             


Glu Gly Lys Asp Val Asp His Lys Val Leu Lys Ala Leu Phe His Arg 
    210                 215                 220                 


Pro Tyr Phe His Val Ser Val Ile Glu Asp Val Ala Gly Ile Ser Ile 
225                 230                 235                 240 


Cys Gly Ala Leu Lys Asn Val Val Ala Leu Gly Cys Gly Phe Val Glu 
                245                 250                 255     


Gly Leu Gly Trp Gly Asn Asn Ala Ser Ala Ala Ile Gln Arg Val Gly 
            260                 265                 270         


Leu Gly Glu Ile Ile Arg Phe Gly Gln Met Phe Phe Pro Glu Ser Arg 
        275                 280                 285             


Glu Glu Thr Tyr Tyr Gln Glu Ser Ala Gly Val Ala Asp Leu Ile Thr 
    290                 295                 300                 


Thr Cys Ala Gly Gly Arg Asn Val Lys Val Ala Arg Leu Met Ala Thr 
305                 310                 315                 320 


Ser Gly Lys Asp Ala Trp Glu Cys Glu Lys Glu Leu Leu Asn Gly Gln 
                325                 330                 335     


Ser Ala Gln Gly Leu Ile Thr Cys Lys Glu Val His Glu Trp Leu Glu 
            340                 345                 350         


Thr Cys Gly Ser Val Glu Asp Phe Pro Leu Phe Glu Ala Val Tyr Gln 
        355                 360                 365             


Ile Val Tyr Asn Asn Tyr Pro Met Lys Asn Leu Pro Asp Met Ile Glu 
    370                 375                 380                 


Glu Leu Asp Leu His Glu Asp 
385                 390     


<210>  23
<211>  2058
<212>  DNA
<213>  Artificial

<220>
<223>  GPD2 disruption

<400>  23
agatcttttg cggcgaggtg ccgatgggtt gctgagggga agagtgttta gcttacggac     60

ctattgccat tgttattccg attaatctat tgttcagcag ctcttctcta ccctgtcatt    120

ctagtatttt tttttttttt ttttggtttt actttttttt cttcttgcct ttttttcttg    180

ttactttttt tctagttttt tttccttcca ctaagctttt tccttgattt atccttgggt    240

tcttctttct actcctttag attttttttt tatatattaa tttttaagtt tatgtatttt    300

ggtagattca attctctttc cctttccttt tccttcgctc cccttcctta tcaatgcttg    360

ctgtcagaag attaacaaga tacacattcc ttaaggcctc gtccccgccg ggtcacccgg    420

ccagcgacat ggaggcccag aataccctcc ttgacagtct tgacgtgcgc agctcagggg    480

catgatgtga ctgtcgcccg tacatttagc ccatacatcc ccatgtataa tcatttgcat    540

ccatacattt tgatggccgc acggcgcgaa gcaaaaatta cggctcctcg ctgcagacct    600

gcgagcaggg aaacgctccc ctcacagacg cgttgaattg tccccacgcc gcgcccctgt    660

agagaaatat aaaaggttag gatttgccac tgaggttctt ctttcatata cttcctttta    720

aaatcttgct aggatacagt tctcacatca catccgaaca taaacaacca tgtaaaatga    780

ccactcttga cgacacggct taccggtacc gcaccagtgt cccgggggac gccgaggcca    840

tcgaggcact ggatgggtcc ttcaccaccg acaccgtctt ccgcgtcacc gccaccgggg    900

acggcttcac cctgcgggag gtgccggtgg acccgcccct gaccaaggtg ttccccgacg    960

acgaatcgga cgacgaatcg gacgccgggg aggacggcga cccggactcc cggacgttcg   1020

tcgcgtacgg ggacgacggc gacctggcgg gcttcgtggt cgtctcgtac tccggctgga   1080

accgccggct gaccgtcgag gacatcgagg tcgccccgga gcaccggggg cacggggtcg   1140

ggcgcgcgtt gatggggctc gcgacggagt tcgcccgcga gcggggcgcc gggcacctct   1200

ggctggaggt caccaacgtc aacgcaccgg cgatccacgc gtaccggcgg atggggttca   1260

ccctctgcgg cctggacacc gccctgtacg acggcaccgc ctcggacggc gagcaggcgc   1320

tctacatgag catgccctgc ccctagtact gacaataaaa agattcttgt tttcaagaac   1380

ttgtcatttg tatagttttt ttatattgta gttgttctat tttaatcaaa tgttagcgtg   1440

atttatattt tttttcgcct cgacatcatc tgcccagatg cgaagttaag tgcgcagaaa   1500

gtaatatcat gcgtcaatcg tatgtgaatg ctggtcgcta tactgctgtc gattcgatac   1560

taacgccgcc atccagtgtc gacggatcct aggtgtacag ggcccaaaag ggcgaattct   1620

gcagatatcc atcacactgg cggccgctcg aggatagtct acaacaacgt ccgcatggaa   1680

gacctaccgg agatgattga agagctagac atcgatgacg aatagacact ctcccccccc   1740

ctccccctct gatctttcct gttgcctctt tttcccccaa ccaatttatc attatacaca   1800

agttctacaa ctactactag taacattact acagttatta taattttcta ttctcttttt   1860

ctttaagaat ctatcattaa cgttaatttc tatatataca taactaccat tatacacgct   1920

attatcgttt acatatcaca tcaccgttaa tgaaagatac gacaccctgt acactaacac   1980

aattaaataa tcgccataac cttttctgtt atctatagcc cttaaagctg tttcttcgag   2040

ctttttcact gcagatct                                                 2058


<210>  24
<211>  816
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  24
ccatatgatc atgtgtcgtc gcacacatat atatatgcct gtatgtgtca gcactaaagt     60

tgcctggcca tccacgctat atatacacgc ctggcggatc tgctcgagga ttgcctacgc    120

gtgggcttga tccaccaacc aacgctcgcc aaatgaactg gcgctttggt cttctgccat    180

cgtccgtaaa ccccggccaa agagaccgga aagatcggtg aaaacatctt gatcttgctc    240

ccgggaattt tagattcagg taggaaattg attacatcaa tactgttacc ctgaatcata    300

ttcgacgatg tcgtctcaca cggaaatata attcatttct tggttttcca aaaaaatttt    360

catttttttt cacttttttg tttcgtcctc cttttttttt tttttttttt attttttttc    420

ctgtgttcac cttttttttt ttcagttgac atctttctgc attcttttct gtgttttttt    480

tttttttttt cgtttttcca ttgttcgttc gttgcctgtt ttttcgccct attgttctcg    540

agcctaaaaa ttttttcctt tcctgctttc ctttcttcgt tcaaagtttc ctattccatt    600

gttctctttg gtaaactcat tgttgtcgga actcagatat attcaggtca atttactgta    660

cttcaattga cttttttctt gaaatttcaa cttgcctttt caacttgttc ttctttttta    720

atcttattct acactttagt tcccttacct tgttcctaat tattgtctag caaaaagaaa    780

acatacacct atttcattca cacactgcag aaaatg                              816


<210>  25
<211>  954
<212>  DNA
<213>  Artificial

<220>
<223>  GCY1 PCR fragment

<400>  25
ctgcagaaaa tgcctgctac tttacatgat tctacgaaaa tcctttctct aaatactgga     60

gcccaaatcc ctcaaatagg tttaggtacg tggcagtcga aagagaacga tgcttataag    120

gctgttttaa ccgctttgaa agatggctac cgacacattg atactgctgc tatttaccgt    180

aatgaagacc aagtcggtca agccatcaag gattcaggtg ttcctcggga agaaatcttt    240

gttactacaa agttatggtg tacacaacac cacgaacctg aagtagcgct ggatcaatca    300

ctaaagaggt taggattgga ctacgtagac ttatatttga tgcattggcc tgccagatta    360

gatccagcct acatcaaaaa tgaagacatc ttgagtgtgc caacaaagaa ggatggttct    420

cgtgcagtgg atatcaccaa ttggaatttc atcaaaacct gggaattaat gcaggaacta    480

ccaaagactg gtaaaactaa ggccgttgga gtctccaact tttctataaa taacctgaaa    540

gatctattag catctcaagg taataagctt acgccagctg ctaaccaagt cgaaatacat    600

ccattactac ctcaagacga attgattaat ttttgtaaaa gtaaaggcat tgtggttgaa    660

gcttattctc cgttaggtag taccgatgct ccactattga aggaaccggt tatccttgaa    720

attgcgaaga aaaataacgt tcaacccgga cacgttgtta ttagctggca cgtccaaaga    780

ggttatgttg tcttgccaaa atctgtgaat cccgatcgaa tcaaaacgaa caggaaaata    840

tttactttgt ctactgagga ctttgaagct atcaataaca tatcgaagga aaagggcgaa    900

aaaagggttg tacatccaaa ttggtctcct ttcgaagtat tcaagtaact taag          954


<210>  26
<211>  2986
<212>  DNA
<213>  Artificial

<220>
<223>  DAK1 PCR fragment

<400>  26
ctcgagtacc ggtttcttct tcagattccc tcatggagaa agtgcggcag atgtatatga     60

cagagtcgcc agtttccaag agactttatt caggcacttc catgataggc aagagagaag    120

acccagagat gttgttgtcc tagttacaca tggtatttat tccagagtat tcctgatgaa    180

atggtttaga tggacatacg aagagtttga atcgtttacc aatgttccta acgggagcgt    240

aatggtgatg gaactggacg aatccatcaa tagatacgtc ctgaggaccg tgctacccaa    300

atggactgat tgtgagggag acctaactac atagtgttta aagattacgg atatttaact    360

tacttagaat aatgccattt ttttgagtta taataatcct acgttagtgt gagcgggatt    420

taaactgtga ggaccttaat acattcagac acttctgcgg tatcacccta cttattccct    480

tcgagattat atctaggaac ccatcaggtt ggtggaagat tacccgttct aagacttttc    540

agcttcctct attgatgtta cacctggaca ccccttttct ggcatccagt ttttaatctt    600

cagtggcatg tgagattctc cgaaattaat taaagcaatc acacaattct ctcggatacc    660

acctcggttg aaactgacag gtggtttgtt acgcatgcta atgcaaagga gcctatatac    720

ctttggctcg gctgctgtaa cagggaatat aaagggcagc ataatttagg agtttagtga    780

acttgcaaca tttactattt tcccttctta cgtaaatatt tttcttttta attctaaatc    840

aatctttttc aattttttgt ttgtattctt ttcttgctta aatctataac tacaaaaaac    900

acatacataa atctagaaaa tgtccgctaa atcgtttgaa gtcacagatc cagtcaattc    960

aagtctcaaa gggtttgccc ttgctaaccc ctccattacg ctggtccctg aagaaaaaat   1020

tctcttcaga aagaccgatt ccgacaagat cgcattaatt tctggtggtg gtagtggaca   1080

tgaacctaca cacgccggtt tcattggtaa gggtatgttg agtggcgccg tggttggcga   1140

aatttttgca tccccttcaa caaaacagat tttaaatgca atccgtttag tcaatgaaaa   1200

tgcgtctggc gttttattga ttgtgaagaa ctacacaggt gatgttttgc attttggtct   1260

gtccgctgag agagcaagag ccttgggtat taactgccgc gttgctgtca taggtgatga   1320

tgttgcagtt ggcagagaaa agggtggtat ggttggtaga agagcattgg caggtaccgt   1380

tttggttcat aagattgtag gtgccttcgc agaagaatat tctagtaagt atggcttaga   1440

cggtacagct aaagtggcta aaattatcaa cgacaatttg gtgaccattg gatcttcttt   1500

agaccattgt aaagttcctg gcaggaaatt cgaaagtgaa ttaaacgaaa aacaaatgga   1560

attgggtatg ggtattcata acgaacctgg tgtgaaagtt ttagacccta ttccttctac   1620

cgaagacttg atctccaagt atatgctacc aaaactattg gatccaaacg ataaggatag   1680

agcttttgta aagtttgatg aagatgatga agttgtcttg ttagttaaca atctcggcgg   1740

tgtttctaat tttgttatta gttctatcac ttccaaaact acggatttct taaaggaaaa   1800

ttacaacata accccggttc aaacaattgc tggcacattg atgacctcct tcaatggtaa   1860

tgggttcagt atcacattac taaacgccac taaggctaca aaggctttgc aatctgattt   1920

tgaggagatc aaatcagtac tagacttgtt gaacgcattt acgaacgcac cgggctggcc   1980

aattgcagat tttgaaaaga cttctgcccc atctgttaac gatgacttgt tacataatga   2040

agtaacagca aaggccgtcg gtacctatga ctttgacaag tttgctgagt ggatgaagag   2100

tggtgctgaa caagttatca agagcgaacc gcacattacg gaactagaca atcaagttgg   2160

tgatggtgat tgtggttaca ctttagtggc aggagttaaa ggcatcaccg aaaaccttga   2220

caagctgtcg aaggactcat tatctcaggc ggttgcccaa atttcagatt tcattgaagg   2280

ctcaatggga ggtacttctg gtggtttata ttctattctt ttgtcgggtt tttcacacgg   2340

attaattcag gtttgtaaat caaaggatga acccgtcact aaggaaattg tggctaagtc   2400

actcggaatt gcattggata ctttatacaa atatacaaag gcaaggaagg gatcatccac   2460

catgattgat gctttagaac cattcgttaa agaatttact gcatctaagg atttcaataa   2520

ggcggtaaaa gctgcagagg aaggtgctaa atccactgct acattcgagg ccaaatttgg   2580

cagagcttcg tatgtcggcg attcatctca agtagaagat cctggtgcag taggcctatg   2640

tgagtttttg aagggggttc aaagcgcctt gtaagtcgag acaaatcgct cttaaatata   2700

tacctaaaga acattaaagc tatattataa gcaaagatac gtaaattttg cttatattat   2760

tatacacata tcatatttct atatttttaa gatttggtta tataatgtac gtaatgcaaa   2820

ggaaataaat tttatacatt attgaacagc gtccaagtaa ctacattatg tgcactaata   2880

gtttagcgtc gtgaagactt tattgtgtcg cgaaaagtaa aaattttaaa aattagagca   2940

ccttgaactt gcgaaaaagg ttctcatcaa ctgtttaaaa cgtacg                  2986


<210>  27
<211>  2651
<212>  DNA
<213>  Artificial

<220>
<223>  GUP1 PCR fragment

<400>  27
ggtacctagg accggtttat cattatcaat actgccattt caaagaatac gtaaataatt     60

aatagtagtg attttcctaa ctttatttag tcaaaaaatt agccttttaa ttctgctgta    120

acccgtacat gcccaaaata gggggcgggt tacacagaat atataacatc gtaggtgtct    180

gggtgaacag tttattcctg gcatccacta aatataatgg agcccgcttt ttaagctggc    240

atccagaaaa aaaaagaatc ccagcaccaa aatattgttt tcttcaccaa ccatcagttc    300

ataggtccat tctcttagcg caactacaga gaacaggggc acaaacaggc aaaaaacggg    360

cacaacctca atggagtgat gcaacctgcc tggagtaaat gatgacacaa ggcaattgac    420

ccacgcatgt atctatctca ttttcttaca ccttctatta ccttctgctc tctctgattt    480

ggaaaaagct gaaaaaaaag gttgaaacca gttccctgaa attattcccc tacttgacta    540

ataagtatat aaagacggta ggtattgatt gtaattctgt aaatctattt cttaaacttc    600

ttaaattcta cttttatagt tagtcttttt tttagtttta aaacaccaag aacttagttt    660

cgaataaaca cacataaaga attcgaaaat gtcgctgatc agcatcctgt ctcccctaat    720

tacttccgag ggcttagatt caagaatcaa accttcacca aaaaaggatg cctctactac    780

cactaagcca tcactatgga aaactactga gttcaaattc tactacattg catttctggt    840

cgtggttccc ttgatgttct atgctgggtt acaagctagt tcgcccgaaa atccaaacta    900

tgcaagatac gaacgtctcc tatctcaagg ttggttattt ggcagaaaag tagacaatag    960

tgattctcaa tataggtttt tcagggacaa ttttgcgcta ttgtcagttt taatgctagt   1020

ccacacttct ataaaacgca ttgtacttta ttcaacaaat atcactaaat tgaggtttga   1080

tctgatattt ggtttgatct ttttagtggc cgctcatggt gtcaattcga taagaatttt   1140

agcccatatg ctaattttat atgccatcgc ccatgtacta aagaacttta gaagaatagc   1200

caccatcagc atttggattt atggtatttc tacgcttttt attaacgaca acttcagagc   1260

atatccattt ggtaatattt gctctttttt aagcccattg gaccattggt atagaggtat   1320

cattccaaga tgggatgtct ttttcaattt tactcttttg agagtcttaa gttacaactt   1380

ggacttctta gagaggtggg agaatttaca aaagaagaaa agtccatcct atgaatcaaa   1440

agaagctaaa tcagccattt tgctcaatga acgtgctaga ttaactgctg cacaccccat   1500

acaggactac agcttaatga attatattgc atatgttact tacacgccac ttttcattgc   1560

cggccccatt ataacattca atgattatgt ttaccaatcg aaacatacct tgccatcaat   1620

aaatttcaaa ttcatttttt actatgcggt gagattcgtt attgctctct tatctatgga   1680

gttcatttta cactttctcc acgttgtggc aatctcaaaa accaaagcgt gggaaaatga   1740

cacacctttc cagatttcca tgattggctt atttaatttg aatattattt ggctaaaact   1800

actgattccg tggaggctgt ttaggctgtg ggctttgcta gacggaatcg atacacctga   1860

aaatatgatc aggtgtgttg ataacaatta cagttcacta gcattctgga gagcttggca   1920

tagaagctac aataagtggg ttgtccgtta catatatatt cctctaggtg gttcaaaaaa   1980

tagagttttg acatcactag cagtcttttc cttcgtagct atatggcatg acatcgaact   2040

aaagttatta ttatggggtt ggctaatagt tttgttcctc ttaccagaaa tttttgctac   2100

ccaaattttc tctcattata ccgacgcagt ctggtacaga cacgtttgcg ctgtcggtgc   2160

tgttttcaac atatgggtta tgatgatcgc taatcttttt ggattctgct tgggctctga   2220

cggtactaaa aaattactaa gcgatatgtt ctgtaccgta tctggtttca aatttgtaat   2280

tttggcaagc gttagtttat tcatcgcagt acaaataatg tttgaaatca gagaagaaga   2340

aaagaggcac ggaatttacc taaaatgctg aggatcccct tttcctttgt cgatatcatg   2400

taattagtta tgtcacgctt acattcacgc cctcctccca catccgctct aaccgaaaag   2460

gaaggagtta gacaacctga agtctaggtc cctatttatt ttttttaata gttatgttag   2520

tattaagaac gttatttata tttcaaattt ttcttttttt tctgtacaaa cgcgtgtacg   2580

catgtaacat tatactgaaa accttgcttg agaaggtttt gggacgctcg aaggcttcct   2640

aggctcgagt t                                                        2651


<210>  28
<211>  3037
<212>  DNA
<213>  Artificial

<220>
<223>  FPS1 PCR fragment

<400>  28
aagagctccg gactagtcgt acgaattcta tccttttgtt gtttccgggt gtacaatatg     60

gacttcctct tttctggcaa ccaaacccat acatcgggat tcctataata ccttcgttgg    120

tctccctaac atgtaggtgg cggaggggag atatacaata gaacagatac cagacaagac    180

ataatgggct aaacaagact acaccaatta cactgcctca ttgatggtgg tacataacga    240

actaatactg tagccctaga cttgatagcc atcatcatat cgaagtttca ctaccctttt    300

tccatttgcc atctattgaa gtaataatag gcgcatgcaa cttcttttct ttttttttct    360

tttctctctc ccccgttgtt gtctcaccat atccgcaatg acaaaaaaat gatggaagac    420

actaaaggaa aaaattaacg acaaagacag caccaacaga tgtcgttgtt ccagagctga    480

tgaggggtat ctcgaagcac acgaaacttt ttccttcctt cattcacgca cactactctc    540

taatgagcaa cggtatacgg ccttccttcc agttacttga atttgaaata aaaaaagttt    600

gctgtcttgc tatcaagtat aaatagacct gcaattatta atcttttgtt tcctcgtcat    660

tgttctcgtt ccctttcttc cttgtttctt tttctgcaca atatttcaag ctataccaag    720

catacaatca actccagctg cattaaaatg agtaatcctc aaaaagctct aaacgacttt    780

ctgtccagtg aatctgttca tacacatgat agttctagga aacaatctaa taagcagtca    840

tccgacgaag gacgctcttc atcacaacct tcacatcatc actctggtgg tactaacaac    900

aataataaca ataataataa taataataac agtaacaaca acaacaacgg caacgatggg    960

ggaaatgatg acgactatga ttatgaaatg caagattata gaccttctcc gcaaagtgcg   1020

cggcctactc ccacgtatgt tccacaatat tctgtagaaa gtgggactgc tttcccgatt   1080

caagaggtta ttcctagcgc atacattaac acacaagata taaaccataa agataacggt   1140

ccgccgagtg caagcagtaa tagagcattc aggcctagag ggcagaccac agtgtcggcc   1200

aacgtgctta acattgaaga tttttacaaa aatgcagacg atgcgcatac catcccggag   1260

tcacatttat cgagaaggag aagtaggtcg agggctacga gtaatgctgg gcacagtgcc   1320

aatacaggcg ccacgaatgg caggactact ggtgcccaaa ctaatatgga aagcaatgaa   1380

tcaccacgta acgtccccat tatggtgaag ccaaagacat tataccagaa ccctcaaaca   1440

cctacagtct tgccctccac ataccatcca attaataaat ggtcttccgt caaaaacact   1500

tatttgaagg aatttttagc cgagtttatg ggaacaatgg ttatgattat tttcggtagt   1560

gctgttgttt gtcaggtcaa tgttgctggg aaaatacagc aggacaattt caacgtggct   1620

ttggataacc ttaacgttac cgggtcttct gcagaaacga tagacgctat gaagagttta   1680

acatccttgg tttcatccgt tgcgggcggt acctttgatg atgtggcatt gggctgggct   1740

gctgccgtgg tgatgggcta tttctgcgct ggtggtagtg ccatctcagg tgctcatttg   1800

aatccgtcta ttacattagc caatttggtg tatagaggtt ttcccctgaa gaaagttcct   1860

tattactttg ctggacaatt gatcggtgcc ttcacaggcg ctttgatctt gtttatttgg   1920

tacaaaaggg tgttacaaga ggcatatagc gattggtgga tgaatgaaag tgttgcggga   1980

atgttttgcg tttttccaaa gccttatcta agttcaggac ggcaattttt ttccgaattt   2040

ttatgtggag ctatgttaca agcaggaaca tttgcgctga ccgatcctta tacgtgtttg   2100

tcctctgatg ttttcccatt gatgatgttt attttgattt tcattatcaa tgcttccatg   2160

gcttatcaga caggtacagc aatgaatttg gctcgtgatc tgggcccacg tcttgcacta   2220

tatgcagttg gatttgatca taaaatgctt tgggtgcatc atcatcattt cttttgggtt   2280

cccatggtag gcccatttat tggtgcgtta atgggggggt tggtttacga tgtctgtatt   2340

tatcagggtc atgaatctcc agtcaactgg tctttaccag tttataagga aatgattatg   2400

agagcctggt ttagaaggcc tggttggaag aagagaaata gagcaagaag aacatcggac   2460

ctgagtgact tctcatacaa taacgatgat gatgaggaat ttggagaaag aatggctctt   2520

caaaagacaa agaccaagtc atctatttca gacaacgaaa atgaagcagg agaaaagaaa   2580

gtgcaattta aatctgttca gcgcggcaaa agaacgtttg gtggtatacc aacaattctt   2640

gaagaagaag attccattga aactgcttcg ctaggtgcga cgacgactga ttctattggg   2700

ttatccgaca catcatcaga agattcgcat tatggtaatg ctaagaaggt aacatgagga   2760

tccccttttc ctttgtcgat atcatgtaat tagttatgtc acgcttacat tcacgccctc   2820

ctcccacatc cgctctaacc gaaaaggaag gagttagaca acctgaagtc taggtcccta   2880

tttatttttt ttaatagtta tgttagtatt aagaacgtta tttatatttc aaatttttct   2940

tttttttctg tacaaacgcg tgtacgcatg taacattata ctgaaaacct tgcttgagaa   3000

ggttttggga cgctcgaagg cttcctaggc tcgagtt                            3037


<210>  29
<211>  12954
<212>  DNA
<213>  Artificial

<220>
<223>  pRN605 plasmid for overexpression of GCY1, DAK1 and GUP1

<400>  29
tacgccaagc tcggaattaa ccctcactaa agggaacaaa agctgggtac cgggcccccc     60

ctcgagccta ggaagccttc gagcgtccca aaaccttctc aagcaaggtt ttcagtataa    120

tgttacatgc gtacacgcgt ttgtacagaa aaaaaagaaa aatttgaaat ataaataacg    180

ttcttaatac taacataact attaaaaaaa ataaataggg acctagactt caggttgtct    240

aactccttcc ttttcggtta gagcggatgt gggaggaggg cgtgaatgta agcgtgacat    300

aactaattac atgatatcga caaaggaaaa ggggatcctc agcattttag gtaaattccg    360

tgcctctttt cttcttctct gatttcaaac attatttgta ctgcgatgaa taaactaacg    420

cttgccaaaa ttacaaattt gaaaccagat acggtacaga acatatcgct tagtaatttt    480

ttagtaccgt cagagcccaa gcagaatcca aaaagattag cgatcatcat aacccatatg    540

ttgaaaacag caccgacagc gcaaacgtgt ctgtaccaga ctgcgtcggt ataatgagag    600

aaaatttggg tagcaaaaat ttctggtaag aggaacaaaa ctattagcca accccataat    660

aataacttta gttcgatgtc atgccatata gctacgaagg aaaagactgc tagtgatgtc    720

aaaactctat tttttgaacc acctagagga atatatatgt aacggacaac ccacttattg    780

tagcttctat gccaagctct ccagaatgct agtgaactgt aattgttatc aacacacctg    840

atcatatttt caggtgtatc gattccgtct agcaaagccc acagcctaaa cagcctccac    900

ggaatcagta gttttagcca aataatattc aaattaaata agccaatcat ggaaatctgg    960

aaaggtgtgt cattttccca cgctttggtt tttgagattg ccacaacgtg gagaaagtgt   1020

aaaatgaact ccatagataa gagagcaata acgaatctca ccgcatagta aaaaatgaat   1080

ttgaaattta ttgatggcaa ggtatgtttc gattggtaaa cataatcatt gaatgttata   1140

atggggccgg caatgaaaag tggcgtgtaa gtaacatatg caatataatt cattaagctg   1200

tagtcctgta tggggtgtgc agcagttaat ctagcacgtt cattgagcaa aatggctgat   1260

ttagcttctt ttgattcata ggatggactt ttcttctttt gtaaattctc ccacctctct   1320

aagaagtcca agttgtaact taagactctc aaaagagtaa aattgaaaaa gacatcccat   1380

cttggaatga tacctctata ccaatggtcc aatgggctta aaaaagagca aatattacca   1440

aatggatatg ctctgaagtt gtcgttaata aaaagcgtag aaataccata aatccaaatg   1500

ctgatggtgg ctattcttct aaagttcttt agtacatggg cgatggcata taaaattagc   1560

atatgggcta aaattcttat cgaattgaca ccatgagcgg ccactaaaaa gatcaaacca   1620

aatatcagat caaacctcaa tttagtgata tttgttgaat aaagtacaat gcgttttata   1680

gaagtgtgga ctagcattaa aactgacaat agcgcaaaat tgtccctgaa aaacctatat   1740

tgagaatcac tattgtctac ttttctgcca aataaccaac cttgagatag gagacgttcg   1800

tatcttgcat agtttggatt ttcgggcgaa ctagcttgta acccagcata gaacatcaag   1860

ggaaccacga ccagaaatgc aatgtagtag aatttgaact cagtagtttt ccatagtgat   1920

ggcttagtgg tagtagaggc atcctttttt ggtgaaggtt tgattcttga atctaagccc   1980

tcggaagtaa ttaggggaga caggatgctg atcagcgaca ttttgaattc tttatgtgtg   2040

tttattcgaa actaagttct tggtgtttta aaactaaaaa aaagactaac tataaaagta   2100

gaatttaaga agtttaagaa atagatttac agaattacaa tcaataccta ccgtctttat   2160

atacttatta gtcaagtagg ggaataattt cagggaactg gtttcaacct tttttttcag   2220

ctttttccaa atcagagaga gcagaaggta atagaaggtg taagaaaatg agatagatac   2280

atgcgtgggt caattgcctt gtgtcatcat ttactccagg caggttgcat cactccattg   2340

aggttgtgcc cgttttttgc ctgtttgtgc ccctgttctc tgtagttgcg ctaagagaat   2400

ggacctatga actgatggtt ggtgaagaaa acaatatttt ggtgctggga ttcttttttt   2460

ttctggatgc cagcttaaaa agcgggctcc attatattta gtggatgcca ggaataaact   2520

gttcacccag acacctacga tgttatatat tctgtgtaac ccgcccccta ttttgggcat   2580

gtacgggtta cagcagaatt aaaaggctaa ttttttgact aaataaagtt aggaaaatca   2640

ctactattaa ttatttacgt attctttgaa atggcagtat tgataatgat aaaccggttt   2700

cttcttcaga ttccctcatg gagaaagtgc ggcagatgta tatgacagag tcgccagttt   2760

ccaagagact ttattcaggc acttccatga taggcaagag agaagaccca gagatgttgt   2820

tgtcctagtt acacatggta tttattccag agtattcctg atgaaatggt ttagatggac   2880

atacgaagag tttgaatcgt ttaccaatgt tcctaacggg agcgtaatgg tgatggaact   2940

ggacgaatcc atcaatagat acgtcctgag gaccgtgcta cccaaatgga ctgattgtga   3000

gggagaccta actacatagt gtttaaagat tacggatatt taacttactt agaataatgc   3060

catttttttg agttataata atcctacgtt agtgtgagcg ggatttaaac tgtgaggacc   3120

ttaatacatt cagacacttc tgcggtatca ccctacttat tcccttcgag attatatcta   3180

ggaacccatc aggttggtgg aagattaccc gttctaagac ttttcagctt cctctattga   3240

tgttacacct ggacacccct tttctggcat ccagttttta atcttcagtg gcatgtgaga   3300

ttctccgaaa ttaattaaag caatcacaca attctctcgg ataccacctc ggttgaaact   3360

gacaggtggt ttgttacgca tgctaatgca aaggagccta tatacctttg gctcggctgc   3420

tgtaacaggg aatataaagg gcagcataat ttaggagttt agtgaacttg caacatttac   3480

tattttccct tcttacgtaa atatttttct ttttaattct aaatcaatct ttttcaattt   3540

tttgtttgta ttcttttctt gcttaaatct ataactacaa aaaacacata cataaatcta   3600

gaaaatgtcc gctaaatcgt ttgaagtcac agatccagtc aattcaagtc tcaaagggtt   3660

tgcccttgct aacccctcca ttacgctggt ccctgaagaa aaaattctct tcagaaagac   3720

cgattccgac aagatcgcat taatttctgg tggtggtagt ggacatgaac ctacacacgc   3780

cggtttcatt ggtaagggta tgttgagtgg cgccgtggtt ggcgaaattt ttgcatcccc   3840

ttcaacaaaa cagattttaa atgcaatccg tttagtcaat gaaaatgcgt ctggcgtttt   3900

attgattgtg aagaactaca caggtgatgt tttgcatttt ggtctgtccg ctgagagagc   3960

aagagccttg ggtattaact gccgcgttgc tgtcataggt gatgatgttg cagttggcag   4020

agaaaagggt ggtatggttg gtagaagagc attggcaggt accgttttgg ttcataagat   4080

tgtaggtgcc ttcgcagaag aatattctag taagtatggc ttagacggta cagctaaagt   4140

ggctaaaatt atcaacgaca atttggtgac cattggatct tctttagacc attgtaaagt   4200

tcctggcagg aaattcgaaa gtgaattaaa cgaaaaacaa atggaattgg gtatgggtat   4260

tcataacgaa cctggtgtga aagttttaga ccctattcct tctaccgaag acttgatctc   4320

caagtatatg ctaccaaaac tattggatcc aaacgataag gatagagctt ttgtaaagtt   4380

tgatgaagat gatgaagttg tcttgttagt taacaatctc ggcggtgttt ctaattttgt   4440

tattagttct atcacttcca aaactacgga tttcttaaag gaaaattaca acataacccc   4500

ggttcaaaca attgctggca cattgatgac ctccttcaat ggtaatgggt tcagtatcac   4560

attactaaac gccactaagg ctacaaaggc tttgcaatct gattttgagg agatcaaatc   4620

agtactagac ttgttgaacg catttacgaa cgcaccgggc tggccaattg cagattttga   4680

aaagacttct gccccatctg ttaacgatga cttgttacat aatgaagtaa cagcaaaggc   4740

cgtcggtacc tatgactttg acaagtttgc tgagtggatg aagagtggtg ctgaacaagt   4800

tatcaagagc gaaccgcaca ttacggaact agacaatcaa gttggtgatg gtgattgtgg   4860

ttacacttta gtggcaggag ttaaaggcat caccgaaaac cttgacaagc tgtcgaagga   4920

ctcattatct caggcggttg cccaaatttc agatttcatt gaaggctcaa tgggaggtac   4980

ttctggtggt ttatattcta ttcttttgtc gggtttttca cacggattaa ttcaggtttg   5040

taaatcaaag gatgaacccg tcactaagga aattgtggct aagtcactcg gaattgcatt   5100

ggatacttta tacaaatata caaaggcaag gaagggatca tccaccatga ttgatgcttt   5160

agaaccattc gttaaagaat ttactgcatc taaggatttc aataaggcgg taaaagctgc   5220

agaggaaggt gctaaatcca ctgctacatt cgaggccaaa tttggcagag cttcgtatgt   5280

cggcgattca tctcaagtag aagatcctgg tgcagtaggc ctatgtgagt ttttgaaggg   5340

ggttcaaagc gccttgtaag tcgagacaaa tcgctcttaa atatatacct aaagaacatt   5400

aaagctatat tataagcaaa gatacgtaaa ttttgcttat attattatac acatatcata   5460

tttctatatt tttaagattt ggttatataa tgtacgtaat gcaaaggaaa taaattttat   5520

acattattga acagcgtcca agtaactaca ttatgtgcac taatagttta gcgtcgtgaa   5580

gactttattg tgtcgcgaaa agtaaaaatt ttaaaaatta gagcaccttg aacttgcgaa   5640

aaaggttctc atcaactgtt taaaacgtac gtgtggaaga acgattacaa caggtgttgt   5700

cctctgagga cataaaatac acaccgagat tcatcaactc attgctggag ttagcatatc   5760

tacaattggg tgaaatgggg agcgatttgc aggcatttgc tcggcatgcc ggtagaggtg   5820

tggtcaataa gagcgacctc atgctatacc tgagaaagca acctgaccta caggaaagag   5880

ttactcaaga ataagaattt tcgttttaaa acctaagagt cactttaaaa tttgtataca   5940

cttatttttt ttataactta tttaataata aaaatcataa atcataagaa attcgcgcgc   6000

ttacttgaat acttcgaaag gagaccaatt tggatgtaca accctttttt cgcccttttc   6060

cttcgatatg ttattgatag cttcaaagtc ctcagtagac aaagtaaata ttttcctgtt   6120

cgttttgatt cgatcgggat tcacagattt tggcaagaca acataacctc tttggacgtg   6180

ccagctaata acaacgtgtc cgggttgaac gttatttttc ttcgcaattt caaggataac   6240

cggttccttc aatagtggag catcggtact acctaacgga gaataagctt caaccacaat   6300

gcctttactt ttacaaaaat taatcaattc gtcttgaggt agtaatggat gtatttcgac   6360

ttggttagca gctggcgtaa gcttattacc ttgagatgct aatagatctt tcaggttatt   6420

tatagaaaag ttggagactc caacggcctt agttttacca gtctttggta gttcctgcat   6480

taattcccag gttttgatga aattccaatt ggtgatatcc actgcacgag aaccatcctt   6540

ctttgttggc acactcaaga tgtcttcatt tttgatgtag gctggatcta atctggcagg   6600

ccaatgcatc aaatataagt ctacgtagtc caatcctaac ctctttagtg attgatccag   6660

cgctacttca ggttcgtggt gttgtgtaca ccataacttt gtagtaacaa agatttcttc   6720

ccgaggaaca cctgaatcct tgatggcttg accgacttgg tcttcattac ggtaaatagc   6780

agcagtatca atgtgtcggt agccatcttt caaagcggtt aaaacagcct tataagcatc   6840

gttctctttc gactgccacg tacctaaacc tatttgaggg atttgggctc cagtatttag   6900

agaaaggatt ttcgtagaat catgtaaagt agcaggcatt ttctgcagtt aattcagtaa   6960

attttcgatc ttgggaagaa aaaagcagta agcgtgaaaa atctaaaagc tgatgtagta   7020

gaagatccta ttctttaaca aagattgacc ttttcttttt cttcttggtt tgagtagaaa   7080

ggggaaggaa gaatacaaga gagaggaaaa aaaggaagat aaaaagagag cgtgatataa   7140

atgaatatat attaaacaag agagattggg aaggaaagga tcaaacaaac ccaaaaatat   7200

ttcaaaaagg agagagagag gcgagtttgg tttcaaaacg gtttatttat ttatgcaaga   7260

ggacgtggaa gaaaaagaag aaggaagaaa aaaatttgaa agaaaaaaac gcgtggcggg   7320

taaagaagaa aatggaaaat agaggccggg tgacagagaa atattgaggg ttaattggaa   7380

aatatgttag ggtgaggcat atgtttttaa gggttttgag gatccgataa ggaagaatgt   7440

aggttaaatg ttgtgcatta attgctgtgg cagcttaccc gcttccccac acatttacta   7500

gttctagagc ggccgccacc gcggtggagc tccaattcgc cctatagtga gtcgtattac   7560

aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt   7620

aatcgccttg cagcacatcc ccccttcgcc agctggcgta atagcgaaga ggcccgcacc   7680

gatcgccctt cccaacagtt gcgcagcctg aatggcgaat ggcgcgacgc gccctgtagc   7740

ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc   7800

gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggtagt   7860

gttagacctg aacaaggttt actaaaaatc cgtaaagaac ttcaattgta cgccaactta   7920

aggcctcgtc cccgccgggt cacccggcca gcgacatgga ggcccagaat accctccttg   7980

acagtcttga cgtgcgcagc tcaggggcat gatgtgactg tcgcccgtac atttagccca   8040

tacatcccca tgtataatca tttgcatcca tacattttga tggccgcacg gcgcgaagca   8100

aaaattacgg ctcctcgctg cagacctgcg agcagggaaa cgctcccctc acagacgcgt   8160

gaattgtccc cacgccgcgc ccctgtagag aaatataaaa ggttaggatt tgccactgag   8220

gttcttcttt catatacttc cttttaaaat cttgctagga tacagttctc acatcacatc   8280

cgaacataaa caaccatggg taaaaagcct gaactcaccg cgacgtctgt cgagaagttt   8340

ctgatcgaaa agttcgacag cgtctccgac ctgatgcagc tctcggaggg cgaagaatct   8400

cgtgctttca gcttcgatgt aggagggcgt ggatatgtcc tgcgggtaaa tagctgcgcc   8460

gatggtttct acaaagatcg ttatgtttat cggcactttg catcggccgc gctcccgatt   8520

ccggaagtgc ttgacattgg ggaattcagc gagagcctga cctattgcat ctcccgccgt   8580

gcacagggtg tcacgttgca agacctgcct gaaaccgaac tgcccgctgt tctgcagccg   8640

gtcgcggagg ccatggatgc gatcgctgcg gccgatctta gccagacgag cgggttcggc   8700

ccattcggac cgcaaggaat cggtcaatac actacatggc gtgatttcat atgcgcgatt   8760

gctgatcccc atgtgtatca ctggcaaact gtgatggacg acaccgtcag tgcgtccgtc   8820

gcgcaggctc tcgatgagct gatgctttgg gccgaggact gccccgaagt ccggcacctc   8880

gtgcacgcgg atttcggctc caacaatgtc ctgacggaca atggccgcat aacagcggtc   8940

attgactgga gcgaggcgat gttcggggat tcccaatacg aggtcgccaa catcttcttc   9000

tggaggccgt ggttggcttg tatggagcag cagacgcgct acttcgagcg gaggcatccg   9060

gagcttgcag gatcgccgcg gctccgggcg tatatgctcc gcattggtct tgaccaactc   9120

tatcagagct tggttgacgg caatttcgat gatgcagctt gggcgcaggg tcgatgcgac   9180

gcaatcgtcc gatccggagc cgggactgtc gggcgtacac aaatcgcccg cagaagcgcg   9240

gccgtctgga ccgatggctg tgtagaagta ctcgccgata gtggaaaccg acgccccagc   9300

actcgtccga gggcaaagga ataatcagta ctgacaataa aaagattctt gttttcaaga   9360

acttgtcatt tgtatagttt ttttatattg tagttgttct attttaatca aatgttagcg   9420

tgatttatat tttttttcgc ctcgacatca tctgcccaga tgcgaagtta agtgcgcaga   9480

aagtaatatc atgcgtcaat cgtatgtgaa tgctggtcgc tatactgctg tcgattcgat   9540

actaacgccg ccatccagtg tcgacggatc ctaggtgtac ataaacttta taaatgaaat   9600

tcataataga aacgacacga aattacaaaa tggaatatgt tcatagggta gacgaaacta   9660

tatacgcaat ctacatacat ttatcaagaa ggagaaaaag gaggatagta aaggaataca   9720

ggtaagcaaa ttgatactaa tggctcaacg tgataaggaa aaagaattgc actttaacat   9780

taatattgac aaggaggagg gcaccacaca aaaagttagg tgtaacagaa aatcatgaaa   9840

ctacgattcc taatttgata ttggaggatt ttctctaaaa aaaaaaaaat acaacaaata   9900

aaaaacactc aatgacctga ccatttgatg gagtttaagt caataccttc ttgaaccatt   9960

tcccataatg gtgaaagttc cctcaagaat tttactctgt cagaaacggc cttacgacgt  10020

agtcgatatg gtgcactctc agtacaatct gctctgatgc cgcatagtta agccagcccc  10080

gacacccgcc aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt  10140

acagacaagc tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac  10200

cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt tttataggtt aatgtcatga  10260

taataatggt ttcttaggac ggatcgcttg cctgtaactt acacgcgcct cgtatctttt  10320

aatgatggaa taatttggga atttactctg tgtttattta tttttatgtt ttgtatttgg  10380

attttagaaa gtaaataaag aaggtagaag agttacggaa tgaagaaaaa aaaataaaca  10440

aaggtttaaa aaatttcaac aaaaagcgta ctttacatat atatttatta gacaagaaaa  10500

gcagattaaa tagatataca ttcgattaac gataagtaaa atgtaaaatc acaggatttt  10560

cgtgtgtggt cttctacaca gacaagatga aacaattcgg cattaatacc tgagagcagg  10620

aagagcaaga taaaaggtag tatttgttgg cgatccccct agagtctttt acatcttcgg  10680

aaaacaaaaa ctattttttc tttaatttct ttttttactt tctattttta atttatatat  10740

ttatattaaa aaatttaaat tataattatt tttatagcac gtgatgaaaa ggacccaggt  10800

ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca  10860

aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg  10920

aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc  10980

cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg  11040

ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt  11100

cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta  11160

ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat  11220

gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga  11280

gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca  11340

acgatcggag gaccgaagga gctaaccgct ttttttcaca acatggggga tcatgtaact  11400

cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc  11460

acgatgcctg tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact  11520

ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt  11580

ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt  11640

gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt  11700

atctacacga cgggcagtca ggcaactatg gatgaacgaa atagacagat cgctgagata  11760

ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag  11820

attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat  11880

ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa  11940

aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca  12000

aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt  12060

ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg  12120

tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc  12180

ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga  12240

cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc  12300

agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagca ttgagaaagc  12360

gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca  12420

ggagagcgca cgagggagct tccagggggg aacgcctggt atctttatag tcctgtcggg  12480

tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gccgagccta  12540

tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct  12600

cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag  12660

tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa  12720

gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc  12780

agctggcacg acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg  12840

agttacctca ctcattaggc accccaggct ttacacttta tgcttccggc tcctatgttg  12900

tgtggaattg tgagcggata acaatttcac acaggaaaca gctatgacca tgat        12954


<210>  30
<211>  10329
<212>  DNA
<213>  Artificial

<220>
<223>  pRN608 plasmid for overexpression of DAK1 and GCY1

<400>  30
agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg     60

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga    120

gatacctaca gcgtgagcat tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca    180

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggga    240

acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt    300

tgtgatgctc gtcagggggg ccgagcctat ggaaaaacgc cagcaacgcg gcctttttac    360

ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt    420

ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga    480

ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc    540

tccccgcgcg ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag    600

cgggcagtga gcgcaacgca attaatgtga gttacctcac tcattaggca ccccaggctt    660

tacactttat gcttccggct cctatgttgt gtggaattgt gagcggataa caatttcaca    720

caggaaacag ctatgaccat gattacgcca agctcggaat taaccctcac taaagggaac    780

aaaagctggg taccgggccc cccctcgagt accggtttct tcttcagatt ccctcatgga    840

gaaagtgcgg cagatgtata tgacagagtc gccagtttcc aagagacttt attcaggcac    900

ttccatgata ggcaagagag aagacccaga gatgttgttg tcctagttac acatggtatt    960

tattccagag tattcctgat gaaatggttt agatggacat acgaagagtt tgaatcgttt   1020

accaatgttc ctaacgggag cgtaatggtg atggaactgg acgaatccat caatagatac   1080

gtcctgagga ccgtgctacc caaatggact gattgtgagg gagacctaac tacatagtgt   1140

ttaaagatta cggatattta acttacttag aataatgcca tttttttgag ttataataat   1200

cctacgttag tgtgagcggg atttaaactg tgaggacctt aatacattca gacacttctg   1260

cggtatcacc ctacttattc ccttcgagat tatatctagg aacccatcag gttggtggaa   1320

gattacccgt tctaagactt ttcagcttcc tctattgatg ttacacctgg acaccccttt   1380

tctggcatcc agtttttaat cttcagtggc atgtgagatt ctccgaaatt aattaaagca   1440

atcacacaat tctctcggat accacctcgg ttgaaactga caggtggttt gttacgcatg   1500

ctaatgcaaa ggagcctata tacctttggc tcggctgctg taacagggaa tataaagggc   1560

agcataattt aggagtttag tgaacttgca acatttacta ttttcccttc ttacgtaaat   1620

atttttcttt ttaattctaa atcaatcttt ttcaattttt tgtttgtatt cttttcttgc   1680

ttaaatctat aactacaaaa aacacataca taaatctaga aaatgtccgc taaatcgttt   1740

gaagtcacag atccagtcaa ttcaagtctc aaagggtttg cccttgctaa cccctccatt   1800

acgctggtcc ctgaagaaaa aattctcttc agaaagaccg attccgacaa gatcgcatta   1860

atttctggtg gtggtagtgg acatgaacct acacacgccg gtttcattgg taagggtatg   1920

ttgagtggcg ccgtggttgg cgaaattttt gcatcccctt caacaaaaca gattttaaat   1980

gcaatccgtt tagtcaatga aaatgcgtct ggcgttttat tgattgtgaa gaactacaca   2040

ggtgatgttt tgcattttgg tctgtccgct gagagagcaa gagccttggg tattaactgc   2100

cgcgttgctg tcataggtga tgatgttgca gttggcagag aaaagggtgg tatggttggt   2160

agaagagcat tggcaggtac cgttttggtt cataagattg taggtgcctt cgcagaagaa   2220

tattctagta agtatggctt agacggtaca gctaaagtgg ctaaaattat caacgacaat   2280

ttggtgacca ttggatcttc tttagaccat tgtaaagttc ctggcaggaa attcgaaagt   2340

gaattaaacg aaaaacaaat ggaattgggt atgggtattc ataacgaacc tggtgtgaaa   2400

gttttagacc ctattccttc taccgaagac ttgatctcca agtatatgct accaaaacta   2460

ttggatccaa acgataagga tagagctttt gtaaagtttg atgaagatga tgaagttgtc   2520

ttgttagtta acaatctcgg cggtgtttct aattttgtta ttagttctat cacttccaaa   2580

actacggatt tcttaaagga aaattacaac ataaccccgg ttcaaacaat tgctggcaca   2640

ttgatgacct ccttcaatgg taatgggttc agtatcacat tactaaacgc cactaaggct   2700

acaaaggctt tgcaatctga ttttgaggag atcaaatcag tactagactt gttgaacgca   2760

tttacgaacg caccgggctg gccaattgca gattttgaaa agacttctgc cccatctgtt   2820

aacgatgact tgttacataa tgaagtaaca gcaaaggccg tcggtaccta tgactttgac   2880

aagtttgctg agtggatgaa gagtggtgct gaacaagtta tcaagagcga accgcacatt   2940

acggaactag acaatcaagt tggtgatggt gattgtggtt acactttagt ggcaggagtt   3000

aaaggcatca ccgaaaacct tgacaagctg tcgaaggact cattatctca ggcggttgcc   3060

caaatttcag atttcattga aggctcaatg ggaggtactt ctggtggttt atattctatt   3120

cttttgtcgg gtttttcaca cggattaatt caggtttgta aatcaaagga tgaacccgtc   3180

actaaggaaa ttgtggctaa gtcactcgga attgcattgg atactttata caaatataca   3240

aaggcaagga agggatcatc caccatgatt gatgctttag aaccattcgt taaagaattt   3300

actgcatcta aggatttcaa taaggcggta aaagctgcag aggaaggtgc taaatccact   3360

gctacattcg aggccaaatt tggcagagct tcgtatgtcg gcgattcatc tcaagtagaa   3420

gatcctggtg cagtaggcct atgtgagttt ttgaaggggg ttcaaagcgc cttgtaagtc   3480

gagacaaatc gctcttaaat atatacctaa agaacattaa agctatatta taagcaaaga   3540

tacgtaaatt ttgcttatat tattatacac atatcatatt tctatatttt taagatttgg   3600

ttatataatg tacgtaatgc aaaggaaata aattttatac attattgaac agcgtccaag   3660

taactacatt atgtgcacta atagtttagc gtcgtgaaga ctttattgtg tcgcgaaaag   3720

taaaaatttt aaaaattaga gcaccttgaa cttgcgaaaa aggttctcat caactgttta   3780

aaacgtacgt gtggaagaac gattacaaca ggtgttgtcc tctgaggaca taaaatacac   3840

accgagattc atcaactcat tgctggagtt agcatatcta caattgggtg aaatggggag   3900

cgatttgcag gcatttgctc ggcatgccgg tagaggtgtg gtcaataaga gcgacctcat   3960

gctatacctg agaaagcaac ctgacctaca ggaaagagtt actcaagaat aagaattttc   4020

gttttaaaac ctaagagtca ctttaaaatt tgtatacact tatttttttt ataacttatt   4080

taataataaa aatcataaat cataagaaat tcgcgcgctt acttgaatac ttcgaaagga   4140

gaccaatttg gatgtacaac ccttttttcg cccttttcct tcgatatgtt attgatagct   4200

tcaaagtcct cagtagacaa agtaaatatt ttcctgttcg ttttgattcg atcgggattc   4260

acagattttg gcaagacaac ataacctctt tggacgtgcc agctaataac aacgtgtccg   4320

ggttgaacgt tatttttctt cgcaatttca aggataaccg gttccttcaa tagtggagca   4380

tcggtactac ctaacggaga ataagcttca accacaatgc ctttactttt acaaaaatta   4440

atcaattcgt cttgaggtag taatggatgt atttcgactt ggttagcagc tggcgtaagc   4500

ttattacctt gagatgctaa tagatctttc aggttattta tagaaaagtt ggagactcca   4560

acggccttag ttttaccagt ctttggtagt tcctgcatta attcccaggt tttgatgaaa   4620

ttccaattgg tgatatccac tgcacgagaa ccatccttct ttgttggcac actcaagatg   4680

tcttcatttt tgatgtaggc tggatctaat ctggcaggcc aatgcatcaa atataagtct   4740

acgtagtcca atcctaacct ctttagtgat tgatccagcg ctacttcagg ttcgtggtgt   4800

tgtgtacacc ataactttgt agtaacaaag atttcttccc gaggaacacc tgaatccttg   4860

atggcttgac cgacttggtc ttcattacgg taaatagcag cagtatcaat gtgtcggtag   4920

ccatctttca aagcggttaa aacagcctta taagcatcgt tctctttcga ctgccacgta   4980

cctaaaccta tttgagggat ttgggctcca gtatttagag aaaggatttt cgtagaatca   5040

tgtaaagtag caggcatttt ctgcagttaa ttcagtaaat tttcgatctt gggaagaaaa   5100

aagcagtaag cgtgaaaaat ctaaaagctg atgtagtaga agatcctatt ctttaacaaa   5160

gattgacctt ttctttttct tcttggtttg agtagaaagg ggaaggaaga atacaagaga   5220

gaggaaaaaa aggaagataa aaagagagcg tgatataaat gaatatatat taaacaagag   5280

agattgggaa ggaaaggatc aaacaaaccc aaaaatattt caaaaaggag agagagaggc   5340

gagtttggtt tcaaaacggt ttatttattt atgcaagagg acgtggaaga aaaagaagaa   5400

ggaagaaaaa aatttgaaag aaaaaaacgc gtggcgggta aagaagaaaa tggaaaatag   5460

aggccgggtg acagagaaat attgagggtt aattggaaaa tatgttaggg tgaggcatat   5520

gtttttaagg gttttgagga tccgataagg aagaatgtag gttaaatgtt gtgcattaat   5580

tgctgtggca gcttacccgc ttccccacac atttactagt tctagagcgg ccgccaccgc   5640

ggtggagctc caattcgccc tatagtgagt cgtattacaa ttcactggcc gtcgttttac   5700

aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca gcacatcccc   5760

ccttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc   5820

gcagcctgaa tggcgaatgg cgcgacgcgc cctgtagcgg cgcattaagc gcggcgggtg   5880

tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg   5940

ctttcttccc ttcctttctc gccacgttcg ccggtagtgt tagacctgaa caaggtttac   6000

taaaaatccg taaagaactt caattgtacg ccaacttaag gcctcgtccc cgccgggtca   6060

cccggccagc gacatggagg cccagaatac cctccttgac agtcttgacg tgcgcagctc   6120

aggggcatga tgtgactgtc gcccgtacat ttagcccata catccccatg tataatcatt   6180

tgcatccata cattttgatg gccgcacggc gcgaagcaaa aattacggct cctcgctgca   6240

gacctgcgag cagggaaacg ctcccctcac agacgcgtga attgtcccca cgccgcgccc   6300

ctgtagagaa atataaaagg ttaggatttg ccactgaggt tcttctttca tatacttcct   6360

tttaaaatct tgctaggata cagttctcac atcacatccg aacataaaca accatgggta   6420

aaaagcctga actcaccgcg acgtctgtcg agaagtttct gatcgaaaag ttcgacagcg   6480

tctccgacct gatgcagctc tcggagggcg aagaatctcg tgctttcagc ttcgatgtag   6540

gagggcgtgg atatgtcctg cgggtaaata gctgcgccga tggtttctac aaagatcgtt   6600

atgtttatcg gcactttgca tcggccgcgc tcccgattcc ggaagtgctt gacattgggg   6660

aattcagcga gagcctgacc tattgcatct cccgccgtgc acagggtgtc acgttgcaag   6720

acctgcctga aaccgaactg cccgctgttc tgcagccggt cgcggaggcc atggatgcga   6780

tcgctgcggc cgatcttagc cagacgagcg ggttcggccc attcggaccg caaggaatcg   6840

gtcaatacac tacatggcgt gatttcatat gcgcgattgc tgatccccat gtgtatcact   6900

ggcaaactgt gatggacgac accgtcagtg cgtccgtcgc gcaggctctc gatgagctga   6960

tgctttgggc cgaggactgc cccgaagtcc ggcacctcgt gcacgcggat ttcggctcca   7020

acaatgtcct gacggacaat ggccgcataa cagcggtcat tgactggagc gaggcgatgt   7080

tcggggattc ccaatacgag gtcgccaaca tcttcttctg gaggccgtgg ttggcttgta   7140

tggagcagca gacgcgctac ttcgagcgga ggcatccgga gcttgcagga tcgccgcggc   7200

tccgggcgta tatgctccgc attggtcttg accaactcta tcagagcttg gttgacggca   7260

atttcgatga tgcagcttgg gcgcagggtc gatgcgacgc aatcgtccga tccggagccg   7320

ggactgtcgg gcgtacacaa atcgcccgca gaagcgcggc cgtctggacc gatggctgtg   7380

tagaagtact cgccgatagt ggaaaccgac gccccagcac tcgtccgagg gcaaaggaat   7440

aatcagtact gacaataaaa agattcttgt tttcaagaac ttgtcatttg tatagttttt   7500

ttatattgta gttgttctat tttaatcaaa tgttagcgtg atttatattt tttttcgcct   7560

cgacatcatc tgcccagatg cgaagttaag tgcgcagaaa gtaatatcat gcgtcaatcg   7620

tatgtgaatg ctggtcgcta tactgctgtc gattcgatac taacgccgcc atccagtgtc   7680

gacggatcct aggtgtacat aaactttata aatgaaattc ataatagaaa cgacacgaaa   7740

ttacaaaatg gaatatgttc atagggtaga cgaaactata tacgcaatct acatacattt   7800

atcaagaagg agaaaaagga ggatagtaaa ggaatacagg taagcaaatt gatactaatg   7860

gctcaacgtg ataaggaaaa agaattgcac tttaacatta atattgacaa ggaggagggc   7920

accacacaaa aagttaggtg taacagaaaa tcatgaaact acgattccta atttgatatt   7980

ggaggatttt ctctaaaaaa aaaaaaatac aacaaataaa aaacactcaa tgacctgacc   8040

atttgatgga gtttaagtca ataccttctt gaaccatttc ccataatggt gaaagttccc   8100

tcaagaattt tactctgtca gaaacggcct tacgacgtag tcgatatggt gcactctcag   8160

tacaatctgc tctgatgccg catagttaag ccagccccga cacccgccaa cacccgctga   8220

cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg tgaccgtctc   8280

cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga gacgaaaggg   8340

cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt cttaggacgg   8400

atcgcttgcc tgtaacttac acgcgcctcg tatcttttaa tgatggaata atttgggaat   8460

ttactctgtg tttatttatt tttatgtttt gtatttggat tttagaaagt aaataaagaa   8520

ggtagaagag ttacggaatg aagaaaaaaa aataaacaaa ggtttaaaaa atttcaacaa   8580

aaagcgtact ttacatatat atttattaga caagaaaagc agattaaata gatatacatt   8640

cgattaacga taagtaaaat gtaaaatcac aggattttcg tgtgtggtct tctacacaga   8700

caagatgaaa caattcggca ttaatacctg agagcaggaa gagcaagata aaaggtagta   8760

tttgttggcg atccccctag agtcttttac atcttcggaa aacaaaaact attttttctt   8820

taatttcttt ttttactttc tatttttaat ttatatattt atattaaaaa atttaaatta   8880

taattatttt tatagcacgt gatgaaaagg acccaggtgg cacttttcgg ggaaatgtgc   8940

gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac   9000

aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt   9060

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag   9120

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg   9180

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa   9240

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc   9300

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag   9360

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa   9420

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc   9480

taaccgcttt ttttcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg   9540

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa   9600

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa   9660

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg   9720

gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag   9780

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg ggcagtcagg   9840

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt   9900

ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt   9960

aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac  10020

gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag  10080

atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg  10140

tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca  10200

gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga  10260

actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca  10320

gtggcgata                                                          10329


<210>  31
<211>  11163
<212>  DNA
<213>  Artificial

<220>
<223>  pRN616

<400>  31
tttgattaaa atagaacaac tacaatataa aaaaactata caaatgacaa gttcttgaaa     60

acaagaatct ttttattgtc agtgtgtcag tcctgctcct cggccacgaa gtgcacgcag    120

ttgccggccg ggtcgcgcag ggcgaactcc cgcccccacg gctgctcgcc gatctcggtc    180

atggccggcc cggaggcgtc ccggaagttc gtggacacga cctccgacca ctcggcgtac    240

agctcgtcca ggccgcgcac ccacacccag gccagggtgt tgtccggcac cacctggtcc    300

tggaccgcgc tgatgaacag ggtcacgtcg tcccggacca caccggcgaa gtcgtcctcc    360

acgaagtccc gggagaaccc gagccggtcg gtccagaact cgaccgctcc ggcgacgtcg    420

cgcgcggtga gcaccggaac ggcactggtc aacttggcca tggttgttta tgttcggatg    480

tgatgtgaga actgtatcct agcaagattt taaaaggaag tatatgaaag aagaacctca    540

gtggcaaatc ctaacctttt atatttctct acaggggcgc ggcgtgggga caattcaacg    600

cgtctgtgag gggagcgttt ccctgctcgc aggtctgcag cgaggagccg taatttttgc    660

ttcgcgccgt gcggccatca aaatgtatgg atgcaaatga ttatacatgg ggatgtatgg    720

gctaaatgta cgggcgacag tcacatcatg cccctgagct gcgcacgtca agactgtcaa    780

ggagggtatt ctgggcctcc atgtcgctgg ccgggtgacc cggcggggac gaggccttaa    840

gcggccgcat gctagctccg gattatcgat gataagctgt caaacatgag aattaattcc    900

acggactata gactatacct agtatactcc gtctactgta cgatacactt ccgctcaggt    960

ccttgtcctt taacgaggcc ttaccactct tttgttactc tattgatcca gctcagcaaa   1020

ggcagtgtga tctaagattc tatcttcgcg atgtagtaaa actagctaga ccgagaaaga   1080

gactagaaat gcaaaaggca cttctacaat ggctgccatc attattatcc gatgtgacgc   1140

tgcagcttct caatgatatt cgaatacgct ttgaggagat acagcctaat atccgacaaa   1200

ctgttttaca gatttacgat cgtacttgtt acccatcatt gaattttgaa catccgaacc   1260

tgggagtttt ccctgaaaca gatagtatat ttgaacctgt ataataatat atagtctagc   1320

gctttacgga agacaatgta tgtatttcgg ttcctggaga aactattgca tctattgcat   1380

aggtaatctt gcacgtcgca tccccggttc attttctgcg tttccatctt gcacttcaat   1440

agcatatctt tgttaacgaa gcatctgtgc ttcattttgt agaacaaaaa tgcaacgcga   1500

gagcgctaat ttttcaaaca aagaatctga gctgcatttt tacagaacag aaatgcaacg   1560

cgaaagcgct attttaccaa cgaagaatct gtgcttcatt tttgtaaaac aaaaatgcaa   1620

cgcgagagcg ctaatttttc aaacaaagaa tctgagctgc atttttacag aacagaaatg   1680

caacgcgaga gcgctatttt accaacaaag aatctatact tcttttttgt tctacaaaaa   1740

tgcatcccga gagcgctatt tttctaacaa agcatcttag attacttttt ttctcctttg   1800

tgcgctctat aatgcagtct cttgataact ttttgcactg taggtccgtt aaggttagaa   1860

gaaggctact ttggtgtcta ttttctcttc cataaaaaaa gcctgactcc acttcccgcg   1920

tttactgatt actagcgaag ctgcgggtgc attttttcaa gataaaggca tccccgatta   1980

tattctatac cgatgtggat tgcgcatact ttgtgaacag aaagtgatag cgttgatgat   2040

tcttcattgg tcagaaaatt atgaacggtt tcttctattt tgtctctata tactacgtat   2100

aggaaatgtt tacattttcg tattgttttc gattcactct atgaatagtt cttactacaa   2160

tttttttgtc taaagagtaa tactagagat aaacataaaa aatgtagagg tcgagtttag   2220

atgcaagttc aaggagcgaa aggtggatgg gtaggttata tagggatata gcacagagat   2280

atatagcaaa gagatacttt tgagcaatgt ttgtggaaag cggtattcgc aatgccggca   2340

aaagggcgaa ttgattttga agagaatgtg gattttgatg taattgttgg gattccattt   2400

ttaataaggc aataatatta ggtatgtgga tatactagaa gttctcctcg accgtcgata   2460

tgcggtgtga aataccgcac agatgcgtaa ggagaaaata ccgcatcagg aaattgtaaa   2520

cgttaatatt ttgttaaaat tcgcgttaaa tttttgttaa atcagctcat tttttaacca   2580

ataggccgaa atcggcaaaa tcccttataa atcaaaagaa tagaccgaga tagggttgag   2640

tgttgttcca gtttggaaca agagtccact attaaagaac gtggactcca acgtcaaagg   2700

gcgaaaaacc gtctatcagg gcgatggccc actacgtgaa ccatcaccct aatcaagttt   2760

tttggggtcg aggtgccgta aagcactaaa tcggaaccct aaagggagcc cccgatttag   2820

agcttgacgg ggaaagccgg cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc   2880

gggcgctagg gcgctggcaa gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc   2940

gcttaatgcg ccgctacagg gcgcgtcgcg ccattcgcca ttcaggctgc gcaactgttg   3000

ggaagggcga tcggtgcggg cctcttcgct attacgccag ctggcgaagg ggggatgtgc   3060

tgcaaggcga ttaagttggg taacgccagg gttttcccag tcacgacgtt gtaaaacgac   3120

ggccagtgaa ttgtaatacg actcactata gggcgaattg gagctccacc gcggtggcgg   3180

ccgctctaga actagtctcg agctcttcaa ctcaagacgc acagatatta taacatctgc   3240

ataataggca tttgcaagaa ttactcgtga gtaaggaaag agtgaggaac tatcgcatac   3300

ctgcatttaa agatgccgat ttgggcgcga atcctttatt ttggcttcac cctcatacta   3360

ttatcagggc cagaaaaagg aagtgtttcc ctccttcttg aattgatgtt accctcataa   3420

agcacgtggc ctcttatcga gaaagaaatt accgtcgctc gtgatttgtt tgcaaaaaga   3480

acaaaactga aaaaacccag acacgctcga cttcctgtct tcctattgat tgcagcttcc   3540

aatttcgtca cacaacaagg tcctagcgac ggctcacagg ttttgtaaca agcaatcgaa   3600

ggttctggaa tggcgggaaa gggtttagta ccacatgcta tgatgcccac tgtgatctcc   3660

agagcaaagt tcgttcgatc gtactgttac tctctctctt tcaaacagaa ttgtccgaat   3720

cgtgtgacaa caacagcctg ttctcacaca ctcttttctt ctaaccaagg gggtggttta   3780

gtttagtaga acctcgtgaa acttacattt acatatatat aaacttgcat aaattggtca   3840

atgcaagaaa tacatatttg gtcttttcta attcgtagtt tttcaagttc ttagatgctt   3900

tctttttctc ttttttacag atcatcaagg aagtaattat ctacttttta caacaaatat   3960

atctagactg cagaaaatgt ctgaattgaa cgagaagttg gctaccgctt gggaaggttt   4020

caccaagggt gactggcaaa acgaagttaa cgttagagac ttcatccaaa agaactacac   4080

cccatacgaa ggtgacgaat ctttcttggc tggtgctacc gaagctacca ccaccttgtg   4140

ggacaaggtt atggaaggtg ttaagttgga aaacagaacc cacgctccag ttgacttcga   4200

caccgctgtt gcttctacca tcacctctca cgacgctggt tacatcaaca agcaattgga   4260

aaagatcgtt ggtttacaaa ccgaagctcc attgaagaga gctttgatcc cattcggtgg   4320

tatcaagatg atcgaaggtt cttgtaaggc ttacaacaga gaattggacc caatgatcaa   4380

gaagattttc accgaataca gaaagaccca caaccaaggt gttttcgacg tttacactcc   4440

agacatcttg agatgtagaa agtctggtgt tttgactggt ttgccagacg cttacggtag   4500

aggtagaatc atcggtgact acagaagagt tgctttgtac ggtatcgact acttgatgaa   4560

ggacaagttg gctcaattca cctctttgca agctgacttg gaaaacggtg ttaacttgga   4620

acaaaccatc agattgagag aagaaatcgc tgaacaacac agagctttgg gtcaaatgaa   4680

ggaaatggct gctaagtacg gttacgacat ctctggtcca gctaccaacg ctcaagaagc   4740

tatccaatgg acctacttcg gttacttggc tgctgttaag tctcaaaacg gtgctgctat   4800

gtctttcggt aggacctcta ccttcttgga cgtttacatc gaaagagact tgaaggctgg   4860

taagatcacc gaacaagaag ctcaagaaat ggttgaccac ttggttatga agttgagaat   4920

ggttagattc ttgagaaccc cagaatacga cgaattgttc tctggtgacc caatctgggc   4980

taccgaatct atcggtggta tgggtttgga cggtagaacc ttggttacca agaactcttt   5040

cagattcttg aacaccttat acaccatggg tccatctcca gaaccaaaca tgaccatctt   5100

gtggtctgaa aagttaccat tgaacttcaa gaagttcgct gctaaggttt ctatcgacac   5160

ctcttctttg caatacgaaa acgacgactt gatgagacca gacttcaaca acgacgacta   5220

cgctatcgct tgttgtgttt ctccaatgat cgttggtaag caaatgcaat tcttcggtgc   5280

tagagctaac ttggctaaga ccatgttgta cgctatcaac ggtggtgttg acgaaaagtt   5340

gaagatgcaa gttggtccaa agtctgaacc aatcaagggt gacgttttga actacgacga   5400

agttatggaa agaatggacc acttcatgga ctggttggct aagcaataca tcaccgcttt   5460

gaacatcatc cactacatgc acgacaagta ctcttacgaa gcatcattga tggctttgca   5520

cgacagagac gtaatcagaa ccatggcttg tggtatcgct ggtttgtctg ttgctgctga   5580

ctctttgtct gctatcaagt acgctaaggt taagccaatc agagacgaag acggtttggc   5640

tatcgacttc gaaatcgaag gtgaataccc tcaattcggt aacaacgacc caagagttga   5700

cgacttggct gttgacttgg ttgaaagatt tatgaagaag atccaaaagt tgcacaccta   5760

cagagacgct atcccaaccc aatctgtttt gactatcaca tctaacgttg tttacggtaa   5820

gaagactggt aacaccccag acggtagaag agctggtgct ccattcggtc caggtgctaa   5880

cccaatgcac ggtagagacc aaaagggtgc tgtagcatct ttgacctctg ttgctaagtt   5940

gccattcgct tacgctaagg acggtatctc ttacaccttc tctatcgttc caaacgcttt   6000

gggtaaggac gatgaagtta gaaagaccaa cttggctggt ttgatggacg gttacttcca   6060

ccacgaagca tctatcgaag gtggtcaaca cttgaacgta aatgttatga acagagaaat   6120

gttgttggac gctatggaaa acccagaaaa gtacccacaa ttgaccatca gagtttctgg   6180

ttacgctgtt agattcaact ctttgaccaa ggaacaacaa caagacgtta tcaccagaac   6240

cttcacccaa tctatgtaag tcgagacaaa tcgctcttaa atatatacct aaagaacatt   6300

aaagctatat tataagcaaa gatacgtaaa ttttgcttat attattatac acatatcata   6360

tttctatatt tttaagattt ggttatataa tgtacgtaat gcaaaggaaa taaattttat   6420

acattattga acagcgtcca agtaactaca ttatgtgcac taatagttta gcgtcgtgaa   6480

gactttattg tgtcgcgaaa agtaaaaatt ttaaaaatta gagcaccttg aacttgcgaa   6540

aaaggttctc atcaactgtt taaaacgtac gtgtggaaga acgattacaa caggtgttgt   6600

cctctgagga cataaaatac acaccgagat tcatcaactc attgctggag ttagcatatc   6660

tacaattggg tgaaatgggg agcgatttgc aggcatttgc tcggcatgcc ggtagaggtg   6720

tggtcaataa gagcgacctc atgctatacc tgagaaagca acctgaccta caggaaagag   6780

ttactcaaga ataagaattt tcgttttaaa acctaagagt cactttaaaa tttgtataca   6840

cttatttttt ttataactta tttaataata aaaatcataa atcataagaa attcgcgcgc   6900

ttagaacata accttgtgac cgtattgttc caagataccc ttaactcttt ccatggtttc   6960

cttctttggt ggcttaacac cgtccaactt gtattcttca cccatagcaa cccacttgtg   7020

cttacccaat tcgtggtatg gcaacaattc gatcttttca acgttaccca tgtctctggt   7080

gaactcaccc aatctgtgag cagagtcgtc gtcgtcagac caacctggaa caacaacgta   7140

tctgatccaa accttaacgt tcttgttagc caagtactta gcaaattcca aggttctgtg   7200

gttagaaaca ccaaccaagt tttggtggat ttcgtcgttc atttgcttca agtccaacat   7260

aaccaagtcg gtaacttcca acaattcgtc gataactggg tcgtatcttc taacgaaacc   7320

gttggtgtcc aaacaggtgt ggataccttc cttcttacaa gctctgaacc agtctctaac   7380

aaattcagct tgcaagatag cttcaccacc agaagcggta acaccacctc ctgaagcgtt   7440

cataaagtgt ctgtaggtaa caacttcctt catcaagtct tcaacagtaa cttccttacc   7500

accgtgggtg tcccaggtgt ctctgttgtg acagtacaaa catctcatca aacaaccttg   7560

gaagaaggtg atgaatctga tacctggacc gtcaacagta ccacaagatt cgaaagagtg   7620

gattctaccg ataacagaca ttttaagctt ctgcagctta gattagattg ctatgctttc   7680

tttctaatga gcaagaagta aaaaaagttg taatagaaca agaaaaatga aactgaaact   7740

tgagaaattg aagaccgttt attaacttaa atatcaatgg gaggtcatcg aaagagaaaa   7800

aaatcaaaaa aaaaaatttt caagaaaaag aaacgtgata aaaattttta ttgccttttt   7860

cgacgaagaa aaagaaacga ggcggtctct tttttctttt ccaaaccttt agtacgggta   7920

attaacgaca ccctagagga agaaagaggg gaaatttagt atgctgtgct tgggtgtttt   7980

gaagtggtac ggcgatgcgc ggagtccgag aaaatctgga agagtaaaaa aggagtagaa   8040

acattttgaa gctatggtgt gtgggaccgg tcgagggggg gcccggtacc cagcttttgt   8100

tccctttagt gagggttaat tccgagcttg gcgtaatcat ggtcatagct gtttcctgtg   8160

tgaaattgtt atccgctcac aattccacac aacataggag ccggaagcat aaagtgtaaa   8220

gcctggggtg cctaatgagt gaggtaactc acattaattg cgttgcgctc actgcccgct   8280

ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa tcggccaacg cgcggggaga   8340

ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc   8400

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa   8460

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt   8520

aaaaaggccg cgttgctggc gtttttccat aggctcggcc cccctgacga gcatcacaaa   8580

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttc   8640

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg   8700

tccgcctttc tcccttcggg aagcgtggcg ctttctcaat gctcacgctg taggtatctc   8760

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc   8820

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta   8880

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct   8940

acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc   9000

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa   9060

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa   9120

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa   9180

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt   9240

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac   9300

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc   9360

atagttgcct gactgcccgt cgtgtagata actacgatac gggagggctt accatctggc   9420

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata   9480

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc   9540

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc   9600

aacgttgttg ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca   9660

ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgaaaaaaa   9720

gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca   9780

ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt   9840

tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt   9900

tgctcttgcc cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg   9960

ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga  10020

tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc  10080

agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg  10140

acacggaaat gttgaatact catactcttc ctttttcaat attattgaag catttatcag  10200

ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg  10260

gttccgcgca catttccccg aaaagtgcca cctgacgtct aagaaaccat tattatcatg  10320

acattaacct ataaaaatag gcgtatcacg aggccctttc gtctcgcgcg tttcggtgat  10380

gacggtgaaa acctctgaca catgcagctc ccggagacgg tcacagcttg tctgtaagcg  10440

gatgccggga gcagacaagc ccgtcagggc gcgtcagcgg gtgttggcgg gtgtcggggc  10500

tggcttaact atgcggcatc agagcagatt gtactgagag tgcaccatat cgactacgtc  10560

gtaaggccgt ttctgacaga gtaaaattct tgagggaact ttcaccatta tgggaaatgg  10620

ttcaagaagg tattgactta aactccatca aatggtcagg tcattgagtg ttttttattt  10680

gttgtatttt ttttttttta gagaaaatcc tccaatatca aattaggaat cgtagtttca  10740

tgattttctg ttacacctaa ctttttgtgt ggtgccctcc tccttgtcaa tattaatgtt  10800

aaagtgcaat tctttttcct tatcacgttg agccattagt atcaatttgc ttacctgtat  10860

tcctttacta tcctcctttt tctccttctt gataaatgta tgtagattgc gtatatagtt  10920

tcgtctaccc tatgaacata ttccattttg taatttcgtg tcgtttctat tatgaatttc  10980

atttataaag tttatgtaca cctaggatcc gtcgacactg gatggcggcg ttagtatcga  11040

atcgacagca gtatagcgac cagcattcac atacgattga cgcatgatat tactttctgc  11100

gcacttaact tcgcatctgg gcagatgatg tcgaggcgaa aaaaaatata aatcacgcta  11160

aca                                                                11163


<210>  32
<211>  7830
<212>  DNA
<213>  Artificial

<220>
<223>  pRN619

<400>  32
aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg     60

cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca    120

cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga    180

aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc    240

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata    300

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg    360

ccacctgacg tctaagaaac cattattatc atgacattaa cctataaaaa taggcgtatc    420

acgaggccct ttcgtctcgc gcgtttcggt gatgacggtg aaaacctctg acacatgcag    480

ctcccggaga cggtcacagc ttgtctgtaa gcggatgccg ggagcagaca agcccgtcag    540

ggcgcgtcag cgggtgttgg cgggtgtcgg ggctggctta actatgcggc atcagagcag    600

attgtactga gagtgcacca tatcgactac gtcgtaaggc cgtttctgac agagtaaaat    660

tcttgaggga actttcacca ttatgggaaa tggttcaaga aggtattgac ttaaactcca    720

tcaaatggtc aggtcattga gtgtttttta tttgttgtat tttttttttt ttagagaaaa    780

tcctccaata tcaaattagg aatcgtagtt tcatgatttt ctgttacacc taactttttg    840

tgtggtgccc tcctccttgt caatattaat gttaaagtgc aattcttttt ccttatcacg    900

ttgagccatt agtatcaatt tgcttacctg tattccttta ctatcctcct ttttctcctt    960

cttgataaat gtatgtagat tgcgtatata gtttcgtcta ccctatgaac atattccatt   1020

ttgtaatttc gtgtcgtttc tattatgaat ttcatttata aagtttatgt acacctagga   1080

tccgtcgaca ctggatggcg gcgttagtat cgaatcgaca gcagtatagc gaccagcatt   1140

cacatacgat tgacgcatga tattactttc tgcgcactta acttcgcatc tgggcagatg   1200

atgtcgaggc gaaaaaaaat ataaatcacg ctaacatttg attaaaatag aacaactaca   1260

atataaaaaa actatacaaa tgacaagttc ttgaaaacaa gaatcttttt attgtcagtg   1320

tgtcagtcct gctcctcggc cacgaagtgc acgcagttgc cggccgggtc gcgcagggcg   1380

aactcccgcc cccacggctg ctcgccgatc tcggtcatgg ccggcccgga ggcgtcccgg   1440

aagttcgtgg acacgacctc cgaccactcg gcgtacagct cgtccaggcc gcgcacccac   1500

acccaggcca gggtgttgtc cggcaccacc tggtcctgga ccgcgctgat gaacagggtc   1560

acgtcgtccc ggaccacacc ggcgaagtcg tcctccacga agtcccggga gaacccgagc   1620

cggtcggtcc agaactcgac cgctccggcg acgtcgcgcg cggtgagcac cggaacggca   1680

ctggtcaact tggccatggt tgtttatgtt cggatgtgat gtgagaactg tatcctagca   1740

agattttaaa aggaagtata tgaaagaaga acctcagtgg caaatcctaa ccttttatat   1800

ttctctacag gggcgcggcg tggggacaat tcaacgcgtc tgtgagggga gcgtttccct   1860

gctcgcaggt ctgcagcgag gagccgtaat ttttgcttcg cgccgtgcgg ccatcaaaat   1920

gtatggatgc aaatgattat acatggggat gtatgggcta aatgtacggg cgacagtcac   1980

atcatgcccc tgagctgcgc acgtcaagac tgtcaaggag ggtattctgg gcctccatgt   2040

cgctggccgg gtgacccggc ggggacgagg ccttaagcgg ccgcatgcta gctccggatt   2100

atcgatgata agctgtcaaa catgagaatt aattccacgg actatagact atacctagta   2160

tactccgtct actgtacgat acacttccgc tcaggtcctt gtcctttaac gaggccttac   2220

cactcttttg ttactctatt gatccagctc agcaaaggca gtgtgatcta agattctatc   2280

ttcgcgatgt agtaaaacta gctagaccga gaaagagact agaaatgcaa aaggcacttc   2340

tacaatggct gccatcatta ttatccgatg tgacgctgca gcttctcaat gatattcgaa   2400

tacgctttga ggagatacag cctaatatcc gacaaactgt tttacagatt tacgatcgta   2460

cttgttaccc atcattgaat tttgaacatc cgaacctggg agttttccct gaaacagata   2520

gtatatttga acctgtataa taatatatag tctagcgctt tacggaagac aatgtatgta   2580

tttcggttcc tggagaaact attgcatcta ttgcataggt aatcttgcac gtcgcatccc   2640

cggttcattt tctgcgtttc catcttgcac ttcaatagca tatctttgtt aacgaagcat   2700

ctgtgcttca ttttgtagaa caaaaatgca acgcgagagc gctaattttt caaacaaaga   2760

atctgagctg catttttaca gaacagaaat gcaacgcgaa agcgctattt taccaacgaa   2820

gaatctgtgc ttcatttttg taaaacaaaa atgcaacgcg agagcgctaa tttttcaaac   2880

aaagaatctg agctgcattt ttacagaaca gaaatgcaac gcgagagcgc tattttacca   2940

acaaagaatc tatacttctt ttttgttcta caaaaatgca tcccgagagc gctatttttc   3000

taacaaagca tcttagatta ctttttttct cctttgtgcg ctctataatg cagtctcttg   3060

ataacttttt gcactgtagg tccgttaagg ttagaagaag gctactttgg tgtctatttt   3120

ctcttccata aaaaaagcct gactccactt cccgcgttta ctgattacta gcgaagctgc   3180

gggtgcattt tttcaagata aaggcatccc cgattatatt ctataccgat gtggattgcg   3240

catactttgt gaacagaaag tgatagcgtt gatgattctt cattggtcag aaaattatga   3300

acggtttctt ctattttgtc tctatatact acgtatagga aatgtttaca ttttcgtatt   3360

gttttcgatt cactctatga atagttctta ctacaatttt tttgtctaaa gagtaatact   3420

agagataaac ataaaaaatg tagaggtcga gtttagatgc aagttcaagg agcgaaaggt   3480

ggatgggtag gttatatagg gatatagcac agagatatat agcaaagaga tacttttgag   3540

caatgtttgt ggaaagcggt attcgcaatg ccggcaaaag ggcgaattga ttttgaagag   3600

aatgtggatt ttgatgtaat tgttgggatt ccatttttaa taaggcaata atattaggta   3660

tgtggatata ctagaagttc tcctcgaccg tcgatatgcg gtgtgaaata ccgcacagat   3720

gcgtaaggag aaaataccgc atcaggaaat tgtaaacgtt aatattttgt taaaattcgc   3780

gttaaatttt tgttaaatca gctcattttt taaccaatag gccgaaatcg gcaaaatccc   3840

ttataaatca aaagaataga ccgagatagg gttgagtgtt gttccagttt ggaacaagag   3900

tccactatta aagaacgtgg actccaacgt caaagggcga aaaaccgtct atcagggcga   3960

tggcccacta cgtgaaccat caccctaatc aagttttttg gggtcgaggt gccgtaaagc   4020

actaaatcgg aaccctaaag ggagcccccg atttagagct tgacggggaa agccggcgaa   4080

cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc gctagggcgc tggcaagtgt   4140

agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt aatgcgccgc tacagggcgc   4200

gtcgcgccat tcgccattca ggctgcgcaa ctgttgggaa gggcgatcgg tgcgggcctc   4260

ttcgctatta cgccagctgg cgaagggggg atgtgctgca aggcgattaa gttgggtaac   4320

gccagggttt tcccagtcac gacgttgtaa aacgacggcc agtgaattgt aatacgactc   4380

actatagggc gaattggagc tccaccgcgg tggcggccgc tctagaacta gtggatcccc   4440

cgggctgcag gaattcgata tcaagcttat cgataccgtc gacctcgacc ggtcccacac   4500

accatagctt caaaatgttt ctactccttt tttactcttc cagattttct cggactccgc   4560

gcatcgccgt accacttcaa aacacccaag cacagcatac taaatttccc ctctttcttc   4620

ctctagggtg tcgttaatta cccgtactaa aggtttggaa aagaaaaaag agaccgcctc   4680

gtttcttttt cttcgtcgaa aaaggcaata aaaattttta tcacgtttct ttttcttgaa   4740

aatttttttt tttgattttt ttctctttcg atgacctccc attgatattt aagttaataa   4800

acggtcttca atttctcaag tttcagtttc atttttcttg ttctattaca acttttttta   4860

cttcttgctc attagaaaga aagcatagca atctaatcta agctgcagaa gcttaaaatg   4920

tctgttatcg gtagaatcca ctctttcgaa tcttgtggta ctgttgacgg tccaggtatc   4980

agattcatca ccttcttcca aggttgtttg atgagatgtt tgtactgtca caacagagac   5040

acctgggaca cccacggtgg taaggaagtt actgttgaag acttgatgaa ggaagttgtt   5100

acctacagac actttatgaa cgcttcagga ggtggtgtta ccgcttctgg tggtgaagct   5160

atcttgcaag ctgaatttgt tagagactgg ttcagagctt gtaagaagga aggtatccac   5220

acctgtttgg acaccaacgg tttcgttaga agatacgacc cagttatcga cgaattgttg   5280

gaagttaccg acttggttat gttggacttg aagcaaatga acgacgaaat ccaccaaaac   5340

ttggttggtg tttctaacca cagaaccttg gaatttgcta agtacttggc taacaagaac   5400

gttaaggttt ggatcagata cgttgttgtt ccaggttggt ctgacgacga cgactctgct   5460

cacagattgg gtgagttcac cagagacatg ggtaacgttg aaaagatcga attgttgcca   5520

taccacgaat tgggtaagca caagtgggtt gctatgggtg aagaatacaa gttggacggt   5580

gttaagccac caaagaagga aaccatggaa agagttaagg gtatcttgga acaatacggt   5640

cacaaggtta tgttctaagc gcgcgaattt cttatgattt atgattttta ttattaaata   5700

agttataaaa aaaataagtg tatacaaatt ttaaagtgac tcttaggttt taaaacgaaa   5760

attcttattc ttgagtaact ctttcctgta ggtcaggttg ctttctcagg tatagcatga   5820

ggtcgctctt attgaccaca cctctaccgg catgccgagc aaatgcctgc aaatcgctcc   5880

ccatttcacc caattgtaga tatgctaact ccagcaatga gttgatgaat ctcggtgtgt   5940

attttatgtc ctcagaggac aacacctgtt gtaatcgttc ttccacacgt acccagcttt   6000

tgttcccttt agtgagggtt aattccgagc ttggcgtaat catggtcata gctgtttcct   6060

gtgtgaaatt gttatccgct cacaattcca cacaacatag gagccggaag cataaagtgt   6120

aaagcctggg gtgcctaatg agtgaggtaa ctcacattaa ttgcgttgcg ctcactgccc   6180

gctttccagt cgggaaacct gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg   6240

agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg   6300

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca   6360

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac   6420

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcg gcccccctga cgagcatcac   6480

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg   6540

ttcccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac   6600

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc aatgctcacg ctgtaggtat   6660

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag   6720

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac   6780

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt   6840

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt   6900

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc   6960

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga   7020

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac   7080

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc   7140

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct   7200

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca   7260

tccatagttg cctgactgcc cgtcgtgtag ataactacga tacgggaggg cttaccatct   7320

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca   7380

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc   7440

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg   7500

cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct   7560

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgaaaa   7620

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta   7680

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc   7740

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg   7800

agttgctctt gcccggcgtc aatacgggat                                    7830


<210>  33
<211>  9695
<212>  DNA
<213>  Artificial

<220>
<223>  pRN620

<400>  33
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca     60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg    120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc    180

accatatcga ctacgtcgta aggccgtttc tgacagagta aaattcttga gggaactttc    240

accattatgg gaaatggttc aagaaggtat tgacttaaac tccatcaaat ggtcaggtca    300

ttgagtgttt tttatttgtt gtattttttt ttttttagag aaaatcctcc aatatcaaat    360

taggaatcgt agtttcatga ttttctgtta cacctaactt tttgtgtggt gccctcctcc    420

ttgtcaatat taatgttaaa gtgcaattct ttttccttat cacgttgagc cattagtatc    480

aatttgctta cctgtattcc tttactatcc tcctttttct ccttcttgat aaatgtatgt    540

agattgcgta tatagtttcg tctaccctat gaacatattc cattttgtaa tttcgtgtcg    600

tttctattat gaatttcatt tataaagttt atgtacacct aggatccgtc gacactggat    660

ggcggcgtta gtatcgaatc gacagcagta tagcgaccag cattcacata cgattgacgc    720

atgatattac tttctgcgca cttaacttcg catctgggca gatgatgtcg aggcgaaaaa    780

aaatataaat cacgctaaca tttgattaaa atagaacaac tacaatataa aaaaactata    840

caaatgacaa gttcttgaaa acaagaatct ttttattgtc agtgtgtcag tcctgctcct    900

cggccacgaa gtgcacgcag ttgccggccg ggtcgcgcag ggcgaactcc cgcccccacg    960

gctgctcgcc gatctcggtc atggccggcc cggaggcgtc ccggaagttc gtggacacga   1020

cctccgacca ctcggcgtac agctcgtcca ggccgcgcac ccacacccag gccagggtgt   1080

tgtccggcac cacctggtcc tggaccgcgc tgatgaacag ggtcacgtcg tcccggacca   1140

caccggcgaa gtcgtcctcc acgaagtccc gggagaaccc gagccggtcg gtccagaact   1200

cgaccgctcc ggcgacgtcg cgcgcggtga gcaccggaac ggcactggtc aacttggcca   1260

tggttgttta tgttcggatg tgatgtgaga actgtatcct agcaagattt taaaaggaag   1320

tatatgaaag aagaacctca gtggcaaatc ctaacctttt atatttctct acaggggcgc   1380

ggcgtgggga caattcaacg cgtctgtgag gggagcgttt ccctgctcgc aggtctgcag   1440

cgaggagccg taatttttgc ttcgcgccgt gcggccatca aaatgtatgg atgcaaatga   1500

ttatacatgg ggatgtatgg gctaaatgta cgggcgacag tcacatcatg cccctgagct   1560

gcgcacgtca agactgtcaa ggagggtatt ctgggcctcc atgtcgctgg ccgggtgacc   1620

cggcggggac gaggccttaa gcggccgcat gctagctccg gattatcgat gataagctgt   1680

caaacatgag aattaattcc acggactata gactatacct agtatactcc gtctactgta   1740

cgatacactt ccgctcaggt ccttgtcctt taacgaggcc ttaccactct tttgttactc   1800

tattgatcca gctcagcaaa ggcagtgtga tctaagattc tatcttcgcg atgtagtaaa   1860

actagctaga ccgagaaaga gactagaaat gcaaaaggca cttctacaat ggctgccatc   1920

attattatcc gatgtgacgc tgcagcttct caatgatatt cgaatacgct ttgaggagat   1980

acagcctaat atccgacaaa ctgttttaca gatttacgat cgtacttgtt acccatcatt   2040

gaattttgaa catccgaacc tgggagtttt ccctgaaaca gatagtatat ttgaacctgt   2100

ataataatat atagtctagc gctttacgga agacaatgta tgtatttcgg ttcctggaga   2160

aactattgca tctattgcat aggtaatctt gcacgtcgca tccccggttc attttctgcg   2220

tttccatctt gcacttcaat agcatatctt tgttaacgaa gcatctgtgc ttcattttgt   2280

agaacaaaaa tgcaacgcga gagcgctaat ttttcaaaca aagaatctga gctgcatttt   2340

tacagaacag aaatgcaacg cgaaagcgct attttaccaa cgaagaatct gtgcttcatt   2400

tttgtaaaac aaaaatgcaa cgcgagagcg ctaatttttc aaacaaagaa tctgagctgc   2460

atttttacag aacagaaatg caacgcgaga gcgctatttt accaacaaag aatctatact   2520

tcttttttgt tctacaaaaa tgcatcccga gagcgctatt tttctaacaa agcatcttag   2580

attacttttt ttctcctttg tgcgctctat aatgcagtct cttgataact ttttgcactg   2640

taggtccgtt aaggttagaa gaaggctact ttggtgtcta ttttctcttc cataaaaaaa   2700

gcctgactcc acttcccgcg tttactgatt actagcgaag ctgcgggtgc attttttcaa   2760

gataaaggca tccccgatta tattctatac cgatgtggat tgcgcatact ttgtgaacag   2820

aaagtgatag cgttgatgat tcttcattgg tcagaaaatt atgaacggtt tcttctattt   2880

tgtctctata tactacgtat aggaaatgtt tacattttcg tattgttttc gattcactct   2940

atgaatagtt cttactacaa tttttttgtc taaagagtaa tactagagat aaacataaaa   3000

aatgtagagg tcgagtttag atgcaagttc aaggagcgaa aggtggatgg gtaggttata   3060

tagggatata gcacagagat atatagcaaa gagatacttt tgagcaatgt ttgtggaaag   3120

cggtattcgc aatgccggca aaagggcgaa ttgattttga agagaatgtg gattttgatg   3180

taattgttgg gattccattt ttaataaggc aataatatta ggtatgtgga tatactagaa   3240

gttctcctcg accgtcgata tgcggtgtga aataccgcac agatgcgtaa ggagaaaata   3300

ccgcatcagg aaattgtaaa cgttaatatt ttgttaaaat tcgcgttaaa tttttgttaa   3360

atcagctcat tttttaacca ataggccgaa atcggcaaaa tcccttataa atcaaaagaa   3420

tagaccgaga tagggttgag tgttgttcca gtttggaaca agagtccact attaaagaac   3480

gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg gcgatggccc actacgtgaa   3540

ccatcaccct aatcaagttt tttggggtcg aggtgccgta aagcactaaa tcggaaccct   3600

aaagggagcc cccgatttag agcttgacgg ggaaagccgg cgaacgtggc gagaaaggaa   3660

gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa gtgtagcggt cacgctgcgc   3720

gtaaccacca cacccgccgc gcttaatgcg ccgctacagg gcgcgtcgcg ccattcgcca   3780

ttcaggctgc gcaactgttg ggaagggcga tcggtgcggg cctcttcgct attacgccag   3840

ctggcgaagg ggggatgtgc tgcaaggcga ttaagttggg taacgccagg gttttcccag   3900

tcacgacgtt gtaaaacgac ggccagtgaa ttgtaatacg actcactata gggcgaattg   3960

gagctccacc gcggtggcgg ccgctctaga actagtggat cccccgggct gcaggaattc   4020

gatatcaagc ttatcgatac cgtcgacctc gagctcttca actcaagacg cacagatatt   4080

ataacatctg cataataggc atttgcaaga attactcgtg agtaaggaaa gagtgaggaa   4140

ctatcgcata cctgcattta aagatgccga tttgggcgcg aatcctttat tttggcttca   4200

ccctcatact attatcaggg ccagaaaaag gaagtgtttc cctccttctt gaattgatgt   4260

taccctcata aagcacgtgg cctcttatcg agaaagaaat taccgtcgct cgtgatttgt   4320

ttgcaaaaag aacaaaactg aaaaaaccca gacacgctcg acttcctgtc ttcctattga   4380

ttgcagcttc caatttcgtc acacaacaag gtcctagcga cggctcacag gttttgtaac   4440

aagcaatcga aggttctgga atggcgggaa agggtttagt accacatgct atgatgccca   4500

ctgtgatctc cagagcaaag ttcgttcgat cgtactgtta ctctctctct ttcaaacaga   4560

attgtccgaa tcgtgtgaca acaacagcct gttctcacac actcttttct tctaaccaag   4620

ggggtggttt agtttagtag aacctcgtga aacttacatt tacatatata taaacttgca   4680

taaattggtc aatgcaagaa atacatattt ggtcttttct aattcgtagt ttttcaagtt   4740

cttagatgct ttctttttct cttttttaca gatcatcaag gaagtaatta tctacttttt   4800

acaacaaata tatctagact gcagaaaatg tctgaattga acgagaagtt ggctaccgct   4860

tgggaaggtt tcaccaaggg tgactggcaa aacgaagtta acgttagaga cttcatccaa   4920

aagaactaca ccccatacga aggtgacgaa tctttcttgg ctggtgctac cgaagctacc   4980

accaccttgt gggacaaggt tatggaaggt gttaagttgg aaaacagaac ccacgctcca   5040

gttgacttcg acaccgctgt tgcttctacc atcacctctc acgacgctgg ttacatcaac   5100

aagcaattgg aaaagatcgt tggtttacaa accgaagctc cattgaagag agctttgatc   5160

ccattcggtg gtatcaagat gatcgaaggt tcttgtaagg cttacaacag agaattggac   5220

ccaatgatca agaagatttt caccgaatac agaaagaccc acaaccaagg tgttttcgac   5280

gtttacactc cagacatctt gagatgtaga aagtctggtg ttttgactgg tttgccagac   5340

gcttacggta gaggtagaat catcggtgac tacagaagag ttgctttgta cggtatcgac   5400

tacttgatga aggacaagtt ggctcaattc acctctttgc aagctgactt ggaaaacggt   5460

gttaacttgg aacaaaccat cagattgaga gaagaaatcg ctgaacaaca cagagctttg   5520

ggtcaaatga aggaaatggc tgctaagtac ggttacgaca tctctggtcc agctaccaac   5580

gctcaagaag ctatccaatg gacctacttc ggttacttgg ctgctgttaa gtctcaaaac   5640

ggtgctgcta tgtctttcgg taggacctct accttcttgg acgtttacat cgaaagagac   5700

ttgaaggctg gtaagatcac cgaacaagaa gctcaagaaa tggttgacca cttggttatg   5760

aagttgagaa tggttagatt cttgagaacc ccagaatacg acgaattgtt ctctggtgac   5820

ccaatctggg ctaccgaatc tatcggtggt atgggtttgg acggtagaac cttggttacc   5880

aagaactctt tcagattctt gaacacctta tacaccatgg gtccatctcc agaaccaaac   5940

atgaccatct tgtggtctga aaagttacca ttgaacttca agaagttcgc tgctaaggtt   6000

tctatcgaca cctcttcttt gcaatacgaa aacgacgact tgatgagacc agacttcaac   6060

aacgacgact acgctatcgc ttgttgtgtt tctccaatga tcgttggtaa gcaaatgcaa   6120

ttcttcggtg ctagagctaa cttggctaag accatgttgt acgctatcaa cggtggtgtt   6180

gacgaaaagt tgaagatgca agttggtcca aagtctgaac caatcaaggg tgacgttttg   6240

aactacgacg aagttatgga aagaatggac cacttcatgg actggttggc taagcaatac   6300

atcaccgctt tgaacatcat ccactacatg cacgacaagt actcttacga agcatcattg   6360

atggctttgc acgacagaga cgtaatcaga accatggctt gtggtatcgc tggtttgtct   6420

gttgctgctg actctttgtc tgctatcaag tacgctaagg ttaagccaat cagagacgaa   6480

gacggtttgg ctatcgactt cgaaatcgaa ggtgaatacc ctcaattcgg taacaacgac   6540

ccaagagttg acgacttggc tgttgacttg gttgaaagat ttatgaagaa gatccaaaag   6600

ttgcacacct acagagacgc tatcccaacc caatctgttt tgactatcac atctaacgtt   6660

gtttacggta agaagactgg taacacccca gacggtagaa gagctggtgc tccattcggt   6720

ccaggtgcta acccaatgca cggtagagac caaaagggtg ctgtagcatc tttgacctct   6780

gttgctaagt tgccattcgc ttacgctaag gacggtatct cttacacctt ctctatcgtt   6840

ccaaacgctt tgggtaagga cgatgaagtt agaaagacca acttggctgg tttgatggac   6900

ggttacttcc accacgaagc atctatcgaa ggtggtcaac acttgaacgt aaatgttatg   6960

aacagagaaa tgttgttgga cgctatggaa aacccagaaa agtacccaca attgaccatc   7020

agagtttctg gttacgctgt tagattcaac tctttgacca aggaacaaca acaagacgtt   7080

atcaccagaa ccttcaccca atctatgtaa gtcgagacaa atcgctctta aatatatacc   7140

taaagaacat taaagctata ttataagcaa agatacgtaa attttgctta tattattata   7200

cacatatcat atttctatat ttttaagatt tggttatata atgtacgtaa tgcaaaggaa   7260

ataaatttta tacattattg aacagcgtcc aagtaactac attatgtgca ctaatagttt   7320

agcgtcgtga agactttatt gtgtcgcgaa aagtaaaaat tttaaaaatt agagcacctt   7380

gaacttgcga aaaaggttct catcaactgt ttaaaacgta cccagctttt gttcccttta   7440

gtgagggtta attccgagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg   7500

ttatccgctc acaattccac acaacatagg agccggaagc ataaagtgta aagcctgggg   7560

tgcctaatga gtgaggtaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc   7620

gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt   7680

gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct   7740

gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga   7800

taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc   7860

cgcgttgctg gcgtttttcc ataggctcgg cccccctgac gagcatcaca aaaatcgacg   7920

ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt tcccccctgg   7980

aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt   8040

tctcccttcg ggaagcgtgg cgctttctca atgctcacgc tgtaggtatc tcagttcggt   8100

gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg   8160

cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact   8220

ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt   8280

cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta tctgcgctct   8340

gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac   8400

cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc   8460

tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg   8520

ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta   8580

aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca   8640

atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc   8700

ctgactgccc gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc   8760

tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc   8820

agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat   8880

taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt   8940

tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc   9000

cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgaaaaa aagcggttag   9060

ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt   9120

tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac   9180

tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg   9240

cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat   9300

tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc   9360

gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc   9420

tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa   9480

atgttgaata ctcatactct tcctttttca atattattga agcatttatc agggttattg   9540

tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg   9600

cacatttccc cgaaaagtgc cacctgacgt ctaagaaacc attattatca tgacattaac   9660

ctataaaaat aggcgtatca cgaggccctt tcgtc                              9695


<210>  34
<211>  14159
<212>  DNA
<213>  Artificial

<220>
<223>  pRN618

<400>  34
tggtatacca acaattcttg aagaagaaga ttccattgaa actgcttcgc taggtgcgac     60

gacgactgat tctattgggt tatccgacac atcatcagaa gattcgcatt atggtaatgc    120

taagaaggta acatgaggat ccccttttcc tttgtcgata tcatgtaatt agttatgtca    180

cgcttacatt cacgccctcc tcccacatcc gctctaaccg aaaaggaagg agttagacaa    240

cctgaagtct aggtccctat ttattttttt taatagttat gttagtatta agaacgttat    300

ttatatttca aatttttctt ttttttctgt acaaacgcgt gtacgcatgt aacattatac    360

tgaaaacctt gcttgagaag gttttgggac gctcgaaggc ttcctaggct cgacactgga    420

tggcggcgtt agtatcgaat cgacagcagt atagcgacca gcattcacat acgattgacg    480

catgatatta ctttctgcgc acttaacttc gcatctgggc agatgatgtc gaggcgaaaa    540

aaaatataaa tcacgctaac atttgattaa aatagaacaa ctacaatata aaaaaactat    600

acaaatgaca agttcttgaa aacaagaatc tttttattgt cagtgtgtca gtcctgctcc    660

tcggccacga agtgcacgca gttgccggcc gggtcgcgca gggcgaactc ccgcccccac    720

ggctgctcgc cgatctcggt catggccggc ccggaggcgt cccggaagtt cgtggacacg    780

acctccgacc actcggcgta cagctcgtcc aggccgcgca cccacaccca ggccagggtg    840

ttgtccggca ccacctggtc ctggaccgcg ctgatgaaca gggtcacgtc gtcccggacc    900

acaccggcga agtcgtcctc cacgaagtcc cgggagaacc cgagccggtc ggtccagaac    960

tcgaccgctc cggcgacgtc gcgcgcggtg agcaccggaa cggcactggt caacttggcc   1020

atggttgttt atgttcggat gtgatgtgag aactgtatcc tagcaagatt ttaaaaggaa   1080

gtatatgaaa gaagaacctc agtggcaaat cctaaccttt tatatttctc tacaggggcg   1140

cggcgtgggg acaattcaac gcgtctgtga ggggagcgtt tccctgctcg caggtctgca   1200

gcgaggagcc gtaatttttg cttcgcgccg tgcggccatc aaaatgtatg gatgcaaatg   1260

attatacatg gggatgtatg ggctaaatgt acgggcgaca gtcacatcat gcccctgagc   1320

tgcgcacgtc aagactgtca aggagggtat tctgggcctc catgtcgctg gccgggtgac   1380

ccggcgggga cgaggcctta agcggccgca tgctagctcc ggattatcga tgataagctg   1440

tcaaacatga gaattaattc cacggactat agactatacc tagtatactc cgtctactgt   1500

acgatacact tccgctcagg tccttgtcct ttaacgaggc cttaccactc ttttgttact   1560

ctattgatcc agctcagcaa aggcagtgtg atctaagatt ctatcttcgc gatgtagtaa   1620

aactagctag accgagaaag agactagaaa tgcaaaaggc acttctacaa tggctgccat   1680

cattattatc cgatgtgacg ctgcagcttc tcaatgatat tcgaatacgc tttgaggaga   1740

tacagcctaa tatccgacaa actgttttac agatttacga tcgtacttgt tacccatcat   1800

tgaattttga acatccgaac ctgggagttt tccctgaaac agatagtata tttgaacctg   1860

tataataata tatagtctag cgctttacgg aagacaatgt atgtatttcg gttcctggag   1920

aaactattgc atctattgca taggtaatct tgcacgtcgc atccccggtt cattttctgc   1980

gtttccatct tgcacttcaa tagcatatct ttgttaacga agcatctgtg cttcattttg   2040

tagaacaaaa atgcaacgcg agagcgctaa tttttcaaac aaagaatctg agctgcattt   2100

ttacagaaca gaaatgcaac gcgaaagcgc tattttacca acgaagaatc tgtgcttcat   2160

ttttgtaaaa caaaaatgca acgcgagagc gctaattttt caaacaaaga atctgagctg   2220

catttttaca gaacagaaat gcaacgcgag agcgctattt taccaacaaa gaatctatac   2280

ttcttttttg ttctacaaaa atgcatcccg agagcgctat ttttctaaca aagcatctta   2340

gattactttt tttctccttt gtgcgctcta taatgcagtc tcttgataac tttttgcact   2400

gtaggtccgt taaggttaga agaaggctac tttggtgtct attttctctt ccataaaaaa   2460

agcctgactc cacttcccgc gtttactgat tactagcgaa gctgcgggtg cattttttca   2520

agataaaggc atccccgatt atattctata ccgatgtgga ttgcgcatac tttgtgaaca   2580

gaaagtgata gcgttgatga ttcttcattg gtcagaaaat tatgaacggt ttcttctatt   2640

ttgtctctat atactacgta taggaaatgt ttacattttc gtattgtttt cgattcactc   2700

tatgaatagt tcttactaca atttttttgt ctaaagagta atactagaga taaacataaa   2760

aaatgtagag gtcgagttta gatgcaagtt caaggagcga aaggtggatg ggtaggttat   2820

atagggatat agcacagaga tatatagcaa agagatactt ttgagcaatg tttgtggaaa   2880

gcggtattcg caatgccggc aaaagggcga attgattttg aagagaatgt ggattttgat   2940

gtaattgttg ggattccatt tttaataagg caataatatt aggtatgtgg atatactaga   3000

agttctcctc gaccgtcgat atgcggtgtg aaataccgca cagatgcgta aggagaaaat   3060

accgcatcag gaaattgtaa acgttaatat tttgttaaaa ttcgcgttaa atttttgtta   3120

aatcagctca ttttttaacc aataggccga aatcggcaaa atcccttata aatcaaaaga   3180

atagaccgag atagggttga gtgttgttcc agtttggaac aagagtccac tattaaagaa   3240

cgtggactcc aacgtcaaag ggcgaaaaac cgtctatcag ggcgatggcc cactacgtga   3300

accatcaccc taatcaagtt ttttggggtc gaggtgccgt aaagcactaa atcggaaccc   3360

taaagggagc ccccgattta gagcttgacg gggaaagccg gcgaacgtgg cgagaaagga   3420

agggaagaaa gcgaaaggag cgggcgctag ggcgctggca agtgtagcgg tcacgctgcg   3480

cgtaaccacc acacccgccg cgcttaatgc gccgctacag ggcgcgtcgc gccattcgcc   3540

attcaggctg cgcaactgtt gggaagggcg atcggtgcgg gcctcttcgc tattacgcca   3600

gctggcgaag gggggatgtg ctgcaaggcg attaagttgg gtaacgccag ggttttccca   3660

gtcacgacgt tgtaaaacga cggccagtga attgtaatac gactcactat agggcgaatt   3720

ggagctccac cgcggtggcg gccgctctag aactagtctc gagctcttca actcaagacg   3780

cacagatatt ataacatctg cataataggc atttgcaaga attactcgtg agtaaggaaa   3840

gagtgaggaa ctatcgcata cctgcattta aagatgccga tttgggcgcg aatcctttat   3900

tttggcttca ccctcatact attatcaggg ccagaaaaag gaagtgtttc cctccttctt   3960

gaattgatgt taccctcata aagcacgtgg cctcttatcg agaaagaaat taccgtcgct   4020

cgtgatttgt ttgcaaaaag aacaaaactg aaaaaaccca gacacgctcg acttcctgtc   4080

ttcctattga ttgcagcttc caatttcgtc acacaacaag gtcctagcga cggctcacag   4140

gttttgtaac aagcaatcga aggttctgga atggcgggaa agggtttagt accacatgct   4200

atgatgccca ctgtgatctc cagagcaaag ttcgttcgat cgtactgtta ctctctctct   4260

ttcaaacaga attgtccgaa tcgtgtgaca acaacagcct gttctcacac actcttttct   4320

tctaaccaag ggggtggttt agtttagtag aacctcgtga aacttacatt tacatatata   4380

taaacttgca taaattggtc aatgcaagaa atacatattt ggtcttttct aattcgtagt   4440

ttttcaagtt cttagatgct ttctttttct cttttttaca gatcatcaag gaagtaatta   4500

tctacttttt acaacaaata tatctagact gcagaaaatg tctgaattga acgagaagtt   4560

ggctaccgct tgggaaggtt tcaccaaggg tgactggcaa aacgaagtta acgttagaga   4620

cttcatccaa aagaactaca ccccatacga aggtgacgaa tctttcttgg ctggtgctac   4680

cgaagctacc accaccttgt gggacaaggt tatggaaggt gttaagttgg aaaacagaac   4740

ccacgctcca gttgacttcg acaccgctgt tgcttctacc atcacctctc acgacgctgg   4800

ttacatcaac aagcaattgg aaaagatcgt tggtttacaa accgaagctc cattgaagag   4860

agctttgatc ccattcggtg gtatcaagat gatcgaaggt tcttgtaagg cttacaacag   4920

agaattggac ccaatgatca agaagatttt caccgaatac agaaagaccc acaaccaagg   4980

tgttttcgac gtttacactc cagacatctt gagatgtaga aagtctggtg ttttgactgg   5040

tttgccagac gcttacggta gaggtagaat catcggtgac tacagaagag ttgctttgta   5100

cggtatcgac tacttgatga aggacaagtt ggctcaattc acctctttgc aagctgactt   5160

ggaaaacggt gttaacttgg aacaaaccat cagattgaga gaagaaatcg ctgaacaaca   5220

cagagctttg ggtcaaatga aggaaatggc tgctaagtac ggttacgaca tctctggtcc   5280

agctaccaac gctcaagaag ctatccaatg gacctacttc ggttacttgg ctgctgttaa   5340

gtctcaaaac ggtgctgcta tgtctttcgg taggacctct accttcttgg acgtttacat   5400

cgaaagagac ttgaaggctg gtaagatcac cgaacaagaa gctcaagaaa tggttgacca   5460

cttggttatg aagttgagaa tggttagatt cttgagaacc ccagaatacg acgaattgtt   5520

ctctggtgac ccaatctggg ctaccgaatc tatcggtggt atgggtttgg acggtagaac   5580

cttggttacc aagaactctt tcagattctt gaacacctta tacaccatgg gtccatctcc   5640

agaaccaaac atgaccatct tgtggtctga aaagttacca ttgaacttca agaagttcgc   5700

tgctaaggtt tctatcgaca cctcttcttt gcaatacgaa aacgacgact tgatgagacc   5760

agacttcaac aacgacgact acgctatcgc ttgttgtgtt tctccaatga tcgttggtaa   5820

gcaaatgcaa ttcttcggtg ctagagctaa cttggctaag accatgttgt acgctatcaa   5880

cggtggtgtt gacgaaaagt tgaagatgca agttggtcca aagtctgaac caatcaaggg   5940

tgacgttttg aactacgacg aagttatgga aagaatggac cacttcatgg actggttggc   6000

taagcaatac atcaccgctt tgaacatcat ccactacatg cacgacaagt actcttacga   6060

agcatcattg atggctttgc acgacagaga cgtaatcaga accatggctt gtggtatcgc   6120

tggtttgtct gttgctgctg actctttgtc tgctatcaag tacgctaagg ttaagccaat   6180

cagagacgaa gacggtttgg ctatcgactt cgaaatcgaa ggtgaatacc ctcaattcgg   6240

taacaacgac ccaagagttg acgacttggc tgttgacttg gttgaaagat ttatgaagaa   6300

gatccaaaag ttgcacacct acagagacgc tatcccaacc caatctgttt tgactatcac   6360

atctaacgtt gtttacggta agaagactgg taacacccca gacggtagaa gagctggtgc   6420

tccattcggt ccaggtgcta acccaatgca cggtagagac caaaagggtg ctgtagcatc   6480

tttgacctct gttgctaagt tgccattcgc ttacgctaag gacggtatct cttacacctt   6540

ctctatcgtt ccaaacgctt tgggtaagga cgatgaagtt agaaagacca acttggctgg   6600

tttgatggac ggttacttcc accacgaagc atctatcgaa ggtggtcaac acttgaacgt   6660

aaatgttatg aacagagaaa tgttgttgga cgctatggaa aacccagaaa agtacccaca   6720

attgaccatc agagtttctg gttacgctgt tagattcaac tctttgacca aggaacaaca   6780

acaagacgtt atcaccagaa ccttcaccca atctatgtaa gtcgagacaa atcgctctta   6840

aatatatacc taaagaacat taaagctata ttataagcaa agatacgtaa attttgctta   6900

tattattata cacatatcat atttctatat ttttaagatt tggttatata atgtacgtaa   6960

tgcaaaggaa ataaatttta tacattattg aacagcgtcc aagtaactac attatgtgca   7020

ctaatagttt agcgtcgtga agactttatt gtgtcgcgaa aagtaaaaat tttaaaaatt   7080

agagcacctt gaacttgcga aaaaggttct catcaactgt ttaaaacgta cgtgtggaag   7140

aacgattaca acaggtgttg tcctctgagg acataaaata cacaccgaga ttcatcaact   7200

cattgctgga gttagcatat ctacaattgg gtgaaatggg gagcgatttg caggcatttg   7260

ctcggcatgc cggtagaggt gtggtcaata agagcgacct catgctatac ctgagaaagc   7320

aacctgacct acaggaaaga gttactcaag aataagaatt ttcgttttaa aacctaagag   7380

tcactttaaa atttgtatac acttattttt tttataactt atttaataat aaaaatcata   7440

aatcataaga aattcgcgcg cttagaacat aaccttgtga ccgtattgtt ccaagatacc   7500

cttaactctt tccatggttt ccttctttgg tggcttaaca ccgtccaact tgtattcttc   7560

acccatagca acccacttgt gcttacccaa ttcgtggtat ggcaacaatt cgatcttttc   7620

aacgttaccc atgtctctgg tgaactcacc caatctgtga gcagagtcgt cgtcgtcaga   7680

ccaacctgga acaacaacgt atctgatcca aaccttaacg ttcttgttag ccaagtactt   7740

agcaaattcc aaggttctgt ggttagaaac accaaccaag ttttggtgga tttcgtcgtt   7800

catttgcttc aagtccaaca taaccaagtc ggtaacttcc aacaattcgt cgataactgg   7860

gtcgtatctt ctaacgaaac cgttggtgtc caaacaggtg tggatacctt ccttcttaca   7920

agctctgaac cagtctctaa caaattcagc ttgcaagata gcttcaccac cagaagcggt   7980

aacaccacct cctgaagcgt tcataaagtg tctgtaggta acaacttcct tcatcaagtc   8040

ttcaacagta acttccttac caccgtgggt gtcccaggtg tctctgttgt gacagtacaa   8100

acatctcatc aaacaacctt ggaagaaggt gatgaatctg atacctggac cgtcaacagt   8160

accacaagat tcgaaagagt ggattctacc gataacagac attttaagct tctgcagctt   8220

agattagatt gctatgcttt ctttctaatg agcaagaagt aaaaaaagtt gtaatagaac   8280

aagaaaaatg aaactgaaac ttgagaaatt gaagaccgtt tattaactta aatatcaatg   8340

ggaggtcatc gaaagagaaa aaaatcaaaa aaaaaaattt tcaagaaaaa gaaacgtgat   8400

aaaaattttt attgcctttt tcgacgaaga aaaagaaacg aggcggtctc ttttttcttt   8460

tccaaacctt tagtacgggt aattaacgac accctagagg aagaaagagg ggaaatttag   8520

tatgctgtgc ttgggtgttt tgaagtggta cggcgatgcg cggagtccga gaaaatctgg   8580

aagagtaaaa aaggagtaga aacattttga agctatggtg tgtgggaccg gtcgaggggg   8640

ggcccggtac ccagcttttg ttccctttag tgagggttaa ttccgagctt ggcgtaatca   8700

tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatagga   8760

gccggaagca taaagtgtaa agcctggggt gcctaatgag tgaggtaact cacattaatt   8820

gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga   8880

atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc   8940

actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg   9000

gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc   9060

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctcggc   9120

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga   9180

ctataaagat accaggcgtt cccccctgga agctccctcg tgcgctctcc tgttccgacc   9240

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcaa   9300

tgctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg   9360

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc   9420

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga   9480

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact   9540

agaaggacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt   9600

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag   9660

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg   9720

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa   9780

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata   9840

tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg   9900

atctgtctat ttcgttcatc catagttgcc tgactgcccg tcgtgtagat aactacgata   9960

cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg  10020

gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct  10080

gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt  10140

tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc  10200

tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga  10260

tcccccatgt tgtgaaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt  10320

aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc  10380

atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa  10440

tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca  10500

catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca  10560

aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct  10620

tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc  10680

gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa  10740

tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt  10800

tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc  10860

taagaaacca ttattatcat gacattaacc tataaaaata ggcgtatcac gaggcccttt  10920

cgtctcgcgc gtttcggtga tgacggtgaa aacctctgac acatgcagct cccggagacg  10980

gtcacagctt gtctgtaagc ggatgccggg agcagacaag cccgtcaggg cgcgtcagcg  11040

ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat cagagcagat tgtactgaga  11100

gtgcaccata tcgactacgt cgtaaggccg tttctgacag agtaaaattc ttgagggaac  11160

tttcaccatt atgggaaatg gttcaagaag gtattgactt aaactccatc aaatggtcag  11220

gtcattgagt gttttttatt tgttgtattt tttttttttt agagaaaatc ctccaatatc  11280

aaattaggaa tcgtagtttc atgattttct gttacaccta actttttgtg tggtgccctc  11340

ctccttgtca atattaatgt taaagtgcaa ttctttttcc ttatcacgtt gagccattag  11400

tatcaatttg cttacctgta ttcctttact atcctccttt ttctccttct tgataaatgt  11460

atgtagattg cgtatatagt ttcgtctacc ctatgaacat attccatttt gtaatttcgt  11520

gtcgtttcta ttatgaattt catttataaa gtttatgtac gaattctatc cttttgttgt  11580

ttccgggtgt acaatatgga cttcctcttt tctggcaacc aaacccatac atcgggattc  11640

ctataatacc ttcgttggtc tccctaacat gtaggtggcg gaggggagat atacaataga  11700

acagatacca gacaagacat aatgggctaa acaagactac accaattaca ctgcctcatt  11760

gatggtggta cataacgaac taatactgta gccctagact tgatagccat catcatatcg  11820

aagtttcact accctttttc catttgccat ctattgaagt aataataggc gcatgcaact  11880

tcttttcttt ttttttcttt tctctctccc ccgttgttgt ctcaccatat ccgcaatgac  11940

aaaaaaatga tggaagacac taaaggaaaa aattaacgac aaagacagca ccaacagatg  12000

tcgttgttcc agagctgatg aggggtatct cgaagcacac gaaacttttt ccttccttca  12060

ttcacgcaca ctactctcta atgagcaacg gtatacggcc ttccttccag ttacttgaat  12120

ttgaaataaa aaaagtttgc tgtcttgcta tcaagtataa atagacctgc aattattaat  12180

cttttgtttc ctcgtcattg ttctcgttcc ctttcttcct tgtttctttt tctgcacaat  12240

atttcaagct ataccaagca tacaatcaac tccagctgca ttaaaatgag taatcctcaa  12300

aaagctctaa acgactttct gtccagtgaa tctgttcata cacatgatag ttctaggaaa  12360

caatctaata agcagtcatc cgacgaagga cgctcttcat cacaaccttc acatcatcac  12420

tctggtggta ctaacaacaa taataacaat aataataata ataataacag taacaacaac  12480

aacaacggca acgatggggg aaatgatgac gactatgatt atgaaatgca agattataga  12540

ccttctccgc aaagtgcgcg gcctactccc acgtatgttc cacaatattc tgtagaaagt  12600

gggactgctt tcccgattca agaggttatt cctagcgcat acattaacac acaagatata  12660

aaccataaag ataacggtcc gccgagtgca agcagtaata gagcattcag gcctagaggg  12720

cagaccacag tgtcggccaa cgtgcttaac attgaagatt tttacaaaaa tgcagacgat  12780

gcgcatacca tcccggagtc acatttatcg agaaggagaa gtaggtcgag ggctacgagt  12840

aatgctgggc acagtgccaa tacaggcgcc acgaatggca ggactactgg tgcccaaact  12900

aatatggaaa gcaatgaatc accacgtaac gtccccatta tggtgaagcc aaagacatta  12960

taccagaacc ctcaaacacc tacagtcttg ccctccacat accatccaat taataaatgg  13020

tcttccgtca aaaacactta tttgaaggaa tttttagccg agtttatggg aacaatggtt  13080

atgattattt tcggtagtgc tgttgtttgt caggtcaatg ttgctgggaa aatacagcag  13140

gacaatttca acgtggcttt ggataacctt aacgttaccg ggtcttctgc agaaacgata  13200

gacgctatga agagtttaac atccttggtt tcatccgttg cgggcggtac ctttgatgat  13260

gtggcattgg gctgggctgc tgccgtggtg atgggctatt tctgcgctgg tggtagtgcc  13320

atctcaggtg ctcatttgaa tccgtctatt acattagcca atttggtgta tagaggtttt  13380

cccctgaaga aagttcctta ttactttgct ggacaattga tcggtgcctt cacaggcgct  13440

ttgatcttgt ttatttggta caaaagggtg ttacaagagg catatagcga ttggtggatg  13500

aatgaaagtg ttgcgggaat gttttgcgtt tttccaaagc cttatctaag ttcaggacgg  13560

caattttttt ccgaattttt atgtggagct atgttacaag caggaacatt tgcgctgacc  13620

gatccttata cgtgtttgtc ctctgatgtt ttcccattga tgatgtttat tttgattttc  13680

attatcaatg cttccatggc ttatcagaca ggtacagcaa tgaatttggc tcgtgatctg  13740

ggcccacgtc ttgcactata tgcagttgga tttgatcata aaatgctttg ggtgcatcat  13800

catcatttct tttgggttcc catggtaggc ccatttattg gtgcgttaat gggggggttg  13860

gtttacgatg tctgtattta tcagggtcat gaatctccag tcaactggtc tttaccagtt  13920

tataaggaaa tgattatgag agcctggttt agaaggcctg gttggaagaa gagaaataga  13980

gcaagaagaa catcggacct gagtgacttc tcatacaata acgatgatga tgaggaattt  14040

ggagaaagaa tggctcttca aaagacaaag accaagtcat ctatttcaga caacgaaaat  14100

gaagcaggag aaaagaaagt gcaatttaaa tctgttcagc gcggcaaaag aacgtttgg   14159


<210>  35
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Primer FDHuf

<400>  35
tcgaagactc cgaatgaaaa agacatgcca g                                    31


<210>  36
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Primer FDHur

<400>  36
tccggatacc aagttcattt tcaatacacc cca                                  33


<210>  37
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Primer FDHdf

<400>  37
atgcatgcag aatggttctt atgccac                                         27


<210>  38
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Primer FDHdr

<400>  38
gaagacagtt ctgttattaa cgacgagcca                                      30


<210>  39
<211>  5577
<212>  DNA
<213>  Artificial

<220>
<223>  pRN621

<400>  39
tctgtgcggt atttcacacc gcatacaggt ggcacttttc ggggaaatgt gcgcggaacc     60

cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc    120

tgataaatgc ttcaataata gcacgtgagg agggccacca tggccaagtt gaccagtgcc    180

gttccggtgc tcaccgcgcg cgacgtcgcc ggagcggtcg agttctggac cgaccggctc    240

gggttctccc gggacttcgt ggaggacgac ttcgccggtg tggtccggga cgacgtgacc    300

ctgttcatca gcgcggtcca ggaccaggtg gtgccggaca acaccctggc ctgggtgtgg    360

gtgcgcggcc tggacgagct gtacgccgag tggtcggagg tcgtgtccac gaacttccgg    420

gacgcctccg ggccggccat gaccgagatc ggcgagcagc cgtgggggcg ggagttcgcc    480

ctgcgcgacc cggccggcaa ctgcgtgcac ttcgtggccg aggagcagga ctgacacgtg    540

ctaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg    600

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc    660

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa    720

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag    780

gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta    840

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta    900

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag    960

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg   1020

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg   1080

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag   1140

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc   1200

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa   1260

aacgccagca acgcggcctt tttacggttc ctgggctttt gctggccttt tgctcacatg   1320

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct   1380

gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa   1440

gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg   1500

cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa tgtgagttag   1560

ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcgtat gttgtgtgga   1620

attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta cgccaagcta   1680

tttaggtgac actatagaat actcaagcta tgcatcaagc ttggtaccga gctcggatcc   1740

actagtaacg gccgccagtg tgctggaatt cgcccttcga agactccgaa tgaaaaagac   1800

atgccagtaa taaaactatt ttgatgttat gcggaatata ctattcttgg attattcact   1860

gttaactaaa agttggagaa atcactctgc actgtcaatc attgaaaaaa agaacatata   1920

aaagggcaca aaattgagtc ttttttaatg agttcttgct gaggaaagtt tagttaatat   1980

atcatttacg taaaatatgc atattcttgt attgtgcttt ttttattcat tttaagcagg   2040

aacaatttac aagtattgca acgctaatca aatcaaaata acagctgaaa attaatatgt   2100

cgaagggaaa ggttttgctg gttctttacg aaggtggtaa gcatgctgaa gagcaggaaa   2160

agttattggg gtgtattgaa aatgaacttg gtatccggag ctcgtacgtt cgaacttaag   2220

gcctcgtccc cgccgggtca cccggccagc gacatggagg cccagaatac cctccttgac   2280

agtcttgacg tgcgcagctc aggggcatga tgtgactgtc gcccgtacat ttagcccata   2340

catccccatg tataatcatt tgcatccata cattttgatg gccgcacggc gcgaagcaaa   2400

aattacggct cctcgctgca gacctgcgag cagggaaacg ctcccctcac agacgcgttg   2460

aattgtcccc acgccgcgcc cctgtagaga aatataaaag gttaggattt gccactgagg   2520

ttcttctttc atatacttcc ttttaaaatc ttgctaggat acagttctca catcacatcc   2580

gaacataaac aaccgggtag cccagaacga cgcccggtcg agatccgtcc cgccaccgcc   2640

gccgacatgg cggcggtctg cgacatcgtc aatcactaca tcgagacgag cacggtcaac   2700

ttccgtacgg agccgcagac tccgcaggag tggatcgacg acctggagcg cctccaggac   2760

cgctacccct ggctcgtcgc cgaggtggag ggcgtcgtcg ccggcatcgc ctacgccggc   2820

ccctggaagg cccgcaacgc ctacgactgg accgtcgagt cgacggtgta cgtctcccac   2880

cggcaccagc ggctcggact gggctccacc ctctacaccc acctgctgaa gtccatggag   2940

acccagggct tcaagagcgt ggtcgccgtc atcggactgc ccaacgaccc gagcgtgcgc   3000

ctgcacgagg cgctcggata caccgcgcgc gggacgctgc gggcagccgg ctacaagcac   3060

gggggctggc acgacgtggg gttctggcag cgcgacttct agctgccggc cccgccccgc   3120

cccgtccggc ccgtcacaca gatctaatca atactgacaa taaaaagatt cttgttttca   3180

agaacttgtc atttgtatag tttttttata ttgtagttgt tctattttaa tcaaatgtta   3240

gcgtgattta tatttttttt cgcctcgaca tcatctgccc agatgcgaag ttaagtgcgc   3300

agaaagtaat atcatgcgtc aatcgtatgt gaatgctggt cgctatactg ctgtcgattc   3360

gatactaacg ccgccatcca gtgtcgacgg atcctaggtg tacagggccc aagggcgaat   3420

tctgcagata tccatcacac tggcggccgc tcgagcatgc atgcagaatg gttcttatgc   3480

caccagagct tatggacaga agaaataaga gtgattatga gtatttgtga gcagaagttt   3540

tccggtctcc ttttgttctt gttttggcgt attctccact attcgtccat agcacattta   3600

taccttagct aaatattttg taaagcaaaa ttttcgttat ctcttaaaaa atagaagagc   3660

ggtttattaa tatcaaataa ttgaaactgc tgatatggta gctatataca aaatctgctg   3720

tcaaaatttg gcagtaaacg atcttcacgg tagcggttca aataaagagg aaaagtcttt   3780

ctcccttact gtttttctgg aatttggctc gtcgttaata acagaactgt cttcgaaggg   3840

cgaattctgc agatatccat cacactggcg gccgctcgag catgcatcta gagggcccaa   3900

ttcgccctat agtgagtcgt attacaattc actggccgtc gttttacaac gtcgtgactg   3960

ggaaaaccct ggcgttaccc aacttaatcg ccttgcagca catccccctt tcgccagctg   4020

gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa cagttgcgca gcctatacgt   4080

acggcagttt aaggtttaca cctataaaag agagagccgt tatcgtctgt ttgtggatgt   4140

acagagtgat attattgaca cgccggggcg acggatggtg atccccctgg ccagtgcacg   4200

tctgctgtca gataaagtct cccgtgaact ttacccggtg gtgcatatcg gggatgaaag   4260

ctggcgcatg atgaccaccg atatggccag tgtgccggtc tccgttatcg gggaagaagt   4320

ggctgatctc agccaccgcg aaaatgacat caaaaacgcc attaacctga tgttctgggg   4380

aatataaatg tcaggcatga gattatcaaa aaggatcttc acctagatcc ttttcacgta   4440

gaaagccagt ccgcagaaac ggtgctgacc ccggatgaat gtcagctact gggctatctg   4500

gacaagggaa aacgcaagcg caaagagaaa gcaggtagct tgcagtgggc ttacatggcg   4560

atagctagac tgggcggttt tatggacagc aagcgaaccg gaattgccag ctggggcgcc   4620

ctctggtaag gttgggaagc cctgcaaagt aaactggatg gctttctcgc cgccaaggat   4680

ctgatggcgc aggggatcaa gctctgatca agagacagga tgaggatcgt ttcgcatgat   4740

tgaacaagat ggattgcacg caggttctcc ggccgcttgg gtggagaggc tattcggcta   4800

tgactgggca caacagacaa tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca   4860

ggggcgcccg gttctttttg tcaagaccga cctgtccggt gccctgaatg aactgcaaga   4920

cgaggcagcg cggctatcgt ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga   4980

cgttgtcact gaagcgggaa gggactggct gctattgggc gaagtgccgg ggcaggatct   5040

cctgtcatct caccttgctc ctgccgagaa agtatccatc atggctgatg caatgcggcg   5100

gctgcatacg cttgatccgg ctacctgccc attcgaccac caagcgaaac atcgcatcga   5160

gcgagcacgt actcggatgg aagccggtct tgtcgatcag gatgatctgg acgaagagca   5220

tcaggggctc gcgccagccg aactgttcgc caggctcaag gcgagcatgc ccgacggcga   5280

ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat atcatggtgg aaaatggccg   5340

cttttctgga ttcatcgact gtggccggct gggtgtggcg gaccgctatc aggacatagc   5400

gttggctacc cgtgatattg ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt   5460

gctttacggt atcgccgctc ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga   5520

gttcttctga attattaacg cttacaattt cctgatgcgg tattttctcc ttacgca      5577


<210>  40
<211>  5830
<212>  DNA
<213>  Artificial

<220>
<223>  pRN622

<400>  40
tatttcacac cgcatacagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt     60

ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg    120

cttcaataat agcacgtgag gagggccacc atggccaagt tgaccagtgc cgttccggtg    180

ctcaccgcgc gcgacgtcgc cggagcggtc gagttctgga ccgaccggct cgggttctcc    240

cgggacttcg tggaggacga cttcgccggt gtggtccggg acgacgtgac cctgttcatc    300

agcgcggtcc aggaccaggt ggtgccggac aacaccctgg cctgggtgtg ggtgcgcggc    360

ctggacgagc tgtacgccga gtggtcggag gtcgtgtcca cgaacttccg ggacgcctcc    420

gggccggcca tgaccgagat cggcgagcag ccgtgggggc gggagttcgc cctgcgcgac    480

ccggccggca actgcgtgca cttcgtggcc gaggagcagg actgacacgt gctaaaactt    540

catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc    600

ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct    660

tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta    720

ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc    780

ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac    840

ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct    900

gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat    960

aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg   1020

acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa   1080

gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg   1140

gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga   1200

cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc   1260

aacgcggcct ttttacggtt cctgggcttt tgctggcctt ttgctcacat gttctttcct   1320

gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct   1380

cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgccca   1440

atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg   1500

tttcccgact ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta gctcactcat   1560

taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc   1620

ggataacaat ttcacacagg aaacagctat gaccatgatt acgccaagct atttaggtga   1680

cactatagaa tactcaagct atgcatcaag cttggtaccg agctcggatc cactagtaac   1740

ggccgccagt gtgctggaat tcgccctttc gaagactccg aatgaaaaag acatgccagt   1800

aataaaaata attgatgtta tgcggaatat actattcttg gattattcac tgttaactaa   1860

aagttggaga aatcactctg cactgtcaat cattgaaaaa aagaacatat aaaagggcac   1920

aaaatcgagt cttttttaat gagttcttgc tgaggaaaat ttagttaata tatcatttac   1980

ataaaacatg catattattg tgttgtactt tctttattca ttttaagcag gaataattac   2040

aagtattgca acgctaatca aatcgaaata acagctgaaa attaatatgt cgaagggaaa   2100

ggttttgctg gttctttatg aaggtggtaa gcatgctgaa gagcaggaaa agttattggg   2160

gtgtattgaa aatgaacttg gtatccggag ctcgtacgtt cgaacttaag gcctcgtccc   2220

cgccgggtca cccggccagc gacatggagg cccagaatac cctccttgac agtcttgacg   2280

tgcgcagctc aggggcatga tgtgactgtc gcccgtacat ttagcccata catccccatg   2340

tataatcatt tgcatccata cattttgatg gccgcacggc gcgaagcaaa aattacggct   2400

cctcgctgca gacctgcgag cagggaaacg ctcccctcac agacgcgttg aattgtcccc   2460

acgccgcgcc cctgtagaga aatataaaag gttaggattt gccactgagg ttcttctttc   2520

atatacttcc ttttaaaatc ttgctaggat acagttctca catcacatcc gaacataaac   2580

aaccatgggt aaggaaaaga ctcacgtttc gaggccgcga ttaaattcca acatggatgc   2640

tgatttatat gggtataaat gggctcgcga taatgtcggg caatcaggtg cgacaatcta   2700

tcgattgtat gggaagcccg atgcgccaga gttgtttctg aaacatggca aaggtagcgt   2760

tgccaatgat gttacagatg agatggtcag actaaactgg ctgacggaat ttatgcctct   2820

tccgaccatc aagcatttta tccgtactcc tgatgatgca tggttactca ccactgcgat   2880

ccccggcaaa acagcattcc aggtattaga agaatatcct gattcaggtg aaaatattgt   2940

tgatgcgctg gcagtgttcc tgcgccggtt gcattcgatt cctgtttgta attgtccttt   3000

taacagcgat cgcgtatttc gtctcgctca ggcgcaatca cgaatgaata acggtttggt   3060

tgatgcgagt gattttgatg acgagcgtaa tggctggcct gttgaacaag tctggaaaga   3120

aatgcataag cttttgccat tctcaccgga ttcagtcgtc actcatggtg atttctcact   3180

tgataacctt atttttgacg aggggaaatt aataggttgt attgatgttg gacgagtcgg   3240

aatcgcagac cgataccagg atcttgccat cctatggaac tgcctcggtg agttttctcc   3300

ttcattacag aaacggcttt ttcaaaaata tggtattgat aatcctgata tgaataaatt   3360

gcagtttcat ttgatgctcg atgagttttt ctaatcagta ctgacaataa aaagattctt   3420

gttttcaaga acttgtcatt tgtatagttt ttttatattg tagttgttct attttaatca   3480

aatgttagcg tgatttatat tttttttcgc ctcgacatca tctgcccaga tgcgaagtta   3540

agtgcgcaga aagtaatatc atgcgtcaat cgtatgtgaa tgctggtcgc tatactgctg   3600

tcgattcgat actaacgccg ccatccagtg tcgacggatc ctaggtgtac agggcccaaa   3660

agggcgaatt ctgcagatat ccatcacact ggcggccgct cgagcatgca gaatggttct   3720

tatgccacca gagcttatgg acagaagaaa taagagtgat tatgagtatt tgtgagcaga   3780

agttttccgg tctccttttg ttcttgtttt ggcgtattct ccactattcg tccatagcac   3840

atttatacct tagctaaata ttttgtaaag caaaattttc gttatctctt aaaaaataga   3900

agagcggttt attaatatca aataattgaa actgctgata tggtagctat atacaaaatc   3960

tgctgtcaaa atttggcagt aaacgatctt cacggtagcg gttcaaataa agaggaaaag   4020

tccttctccc ttactgtttt tctggaattt ggctcgtcgt taataacaga actgtcttca   4080

agggcgaatt ctgcagatat ccatcacact ggcggccgct cgagcatgca tctagagggc   4140

ccaattcgcc ctatagtgag tcgtattaca attcactggc cgtcgtttta caacgtcgtg   4200

actgggaaaa ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca   4260

gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctat   4320

acgtacggca gtttaaggtt tacacctata aaagagagag ccgttatcgt ctgtttgtgg   4380

atgtacagag tgatattatt gacacgccgg ggcgacggat ggtgatcccc ctggccagtg   4440

cacgtctgct gtcagataaa gtctcccgtg aactttaccc ggtggtgcat atcggggatg   4500

aaagctggcg catgatgacc accgatatgg ccagtgtgcc ggtctccgtt atcggggaag   4560

aagtggctga tctcagccac cgcgaaaatg acatcaaaaa cgccattaac ctgatgttct   4620

ggggaatata aatgtcaggc atgagattat caaaaaggat cttcacctag atccttttca   4680

cgtagaaagc cagtccgcag aaacggtgct gaccccggat gaatgtcagc tactgggcta   4740

tctggacaag ggaaaacgca agcgcaaaga gaaagcaggt agcttgcagt gggcttacat   4800

ggcgatagct agactgggcg gttttatgga cagcaagcga accggaattg ccagctgggg   4860

cgccctctgg taaggttggg aagccctgca aagtaaactg gatggctttc tcgccgccaa   4920

ggatctgatg gcgcagggga tcaagctctg atcaagagac aggatgagga tcgtttcgca   4980

tgattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag aggctattcg   5040

gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag   5100

cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc   5160

aagacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc   5220

tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg   5280

atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct gatgcaatgc   5340

ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca   5400

tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag   5460

agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgagc atgcccgacg   5520

gcgaggatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg gtggaaaatg   5580

gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca   5640

tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc   5700

tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat cgccttcttg   5760

acgagttctt ctgaattatt aacgcttaca atttcctgat gcggtatttt ctccttacgc   5820

atctgtgcgg                                                          5830


<210>  41
<211>  7690
<212>  DNA
<213>  Artificial

<220>
<223>  pRN558

<400>  41
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca     60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg    120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc    180

accataattc cgttttaaga gcttggtgag cgctaggagt cactgccagg tatcgtttga    240

acacggcatt agtcagggaa gtcataacac agtcctttcc cgcaattttc tttttctatt    300

actcttggcc tcctctagta cactctatat ttttttatgc ctcggtaatg attttcattt    360

ttttttttcc acctagcgga tgactctttt tttttcttag cgattggcat tatcacataa    420

tgaattatac attatataaa gtaatgtgat ttcttcgaag aatatactaa aaaatgagca    480

ggcaagataa acgaaggcaa agatgacaga gcagaaagcc ctagtaaagc gtattacaaa    540

tgaaaccaag attcagattg cgatctcttt aaagggtggt cccctagcga tagagcactc    600

gatcttccca gaaaaagagg cagaagcagt agcagaacag gccacacaat cgcaagtgat    660

taacgtccac acaggtatag ggtttctgga ccatatgata catgctctgg ccaagcattc    720

cggctggtcg ctaatcgttg agtgcattgg tgacttacac atagacgacc atcacaccac    780

tgaagactgc gggattgctc tcggtcaagc ttttaaagag gccctactgg cgcgtggagt    840

aaaaaggttt ggatcaggat ttgcgccttt ggatgaggca ctttccagag cggtggtaga    900

tctttcgaac aggccgtacg cagttgtcga acttggtttg caaagggaga aagtaggaga    960

tctctcttgc gagatgatcc cgcattttct tgaaagcttt gcagaggcta gcagaattac   1020

cctccacgtt gattgtctgc gaggcaagaa tgatcatcac cgtagtgaga gtgcgttcaa   1080

ggctcttgcg gttgccataa gagaagccac ctcgcccaat ggtaccaacg atgttccctc   1140

caccaaaggt gttcttatgt agtgacaccg attatttaaa gctgcagcat acgatatata   1200

tacatgtgta tatatgtata cctatgaatg tcagtaagta tgtatacgaa cagtatgata   1260

ctgaagatga caaggtaatg catcattcta tacgtgtcat tctgaacgag gcgcgctttc   1320

cttttttctt tttgcttttt cttttttttt ctcttgaact cgacggatca tatgcggtgt   1380

gaaataccgc acagatgcgt aaggagaaaa taccgcatca ggaaattgta aacgttaata   1440

ttttgttaaa attcgcgtta aatttttgtt aaatcagctc attttttaac caataggccg   1500

aaatcggcaa aatcccttat aaatcaaaag aatagaccga gatagggttg agtgttgttc   1560

cagtttggaa caagagtcca ctattaaaga acgtggactc caacgtcaaa gggcgaaaaa   1620

ccgtctatca gggcgatggc ccactacgtg aaccatcacc ctaatcaagt tttttggggt   1680

cgaggtgccg taaagcacta aatcggaacc ctaaagggag cccccgattt agagcttgac   1740

ggggaaagcc ggcattgcga ataccgcttc cacaaacatt gctcaaaagt atctctttgc   1800

tatatatctc tgtgctatat ccctatataa cctacccatc cacctttcgc tccttgaact   1860

tgcatctaaa ctcgacctct acatttttta tgtttatctc tagtattact ctttagacaa   1920

aaaaattgta gtaagaacta ttcatagagt gaatcgaaaa caatacgaaa atgtaaacat   1980

ttcctatacg tagtatatag agacaaaata gaagaaaccg ttcataattt tctgaccaat   2040

gaagaatcat caacgctatc actttctgtt cacaaagtat gcgcaatcca catcggtata   2100

gaatataatc ggggatgcct ttatcttgaa aaaatgcacc cgcagcttcg ctagtaatca   2160

gtaaacgcgg gaagtggagt caggcttttt ttatggaaga gaaaatagac accaaagtag   2220

ccttcttcta accttaacgg acctacagtg caaaaagtta tcaagagact gcattataga   2280

gcgcacaaag gagaaaaaaa gtaatctaag atgctttgtt agaaaaatag cgctctcggg   2340

atgcattttt gtagaacaaa aaagaagtat agattctttg ttggtaaaat agcgctctcg   2400

cgttgcattt ctgttctgta aaaatgcagc tcagattctt tgtttgaaaa attagcgctc   2460

tcgtcgcgtt gcatttttgt tttacaaaaa tgaagcacag attcttcgtt ggtaaaatag   2520

cgctttcgcg ttgcatttct gttctgtaaa aatgcagctc agattctttg tttgaaaaat   2580

tagcgctctc gcgttgcatt tttgttctac aaaatgaagc acagatgctt cgttaacaaa   2640

gatatgctat tgaagtgcaa gatggaaacg cagaaaatga accggggatg cgacgtgcaa   2700

gattacctat gcaatagatg caatagtttc tccaggaacc gaaatacata cattgtcttc   2760

cgtaaagcgc tagactatat attattatac aggttcaaat atactatctg tttcagggaa   2820

aactcccagg ttcggatgtt caaaattcaa tgatgggtaa caagtacgat cgtaaatctg   2880

taaaacagtt tgtcggatat taggctgtat ctcctcaaag cgtattcgaa tatcattgag   2940

aagctgcagc gtcacatcgg ataataatga tggcagccat tgtagaagtg ccttttgcat   3000

ttctagtctc tttctcggtc tagctagttt tactacatcg cgaagataga atcttagatc   3060

acactgcctt tgctgagctg gatcaataga gtaacaaaag agtggtaagg cctcgttaaa   3120

ggacaaggac ctgagcggaa gtgtatcgta cagtagacgg agtatctagt atagtctata   3180

gtccgtggaa ttaattctca tctttgacag cttatcatcg ataatccgga gctagcatgc   3240

ggccgccagt gtgatggata tctgcagaat tcgccctttt aagcttcgta cgtgtggaag   3300

aacgattaca acaggtgttg tcctctgagg acataaaata cacaccgaga ttcatcaact   3360

cattgctgga gttagcatat ctacaattgg gtgaaatggg gagcgatttg caggcatttg   3420

ctcggcatgc cggtagaggt gtggtcaata agagcgacct catgctatac ctgagaaagc   3480

aacctgacct acaggaaaga gttactcaag aataagaatt ttcgttttaa aacctaagag   3540

tcactttaaa atttgtatac acttattttt tttataactt atttaataat aaaaatcata   3600

aatcataaga aattcgcgcg cttaagcagc ttcaccagcc tttctagcca aagattgagc   3660

catcttttca gcggtagcca aagcagaaga ggtcataatg tccaagttac cagcgtaagc   3720

tggcaagtag tgagcagcac cttcaacttc caaccaaaca gcggtcttca aaccagagaa   3780

ttgaccaaca cctggcaagt taactggctt gtcttgtggg ataacttcga attgaactct   3840

ttgcttcaat ctgtaacctg gaacgtatgc ttgaacagct tcagccattt cgttgattga   3900

agcttcgatg tcgtcttgag atgcttcgtc agacaaaacg taaacggtgt ctctcatcat   3960

caatggtggt tcagctgggt tcaaaacgat gatagcctta cccttagcag caccaccaac   4020

aacttcgata gccctagagg tggtttcggt gaattcgtcg atgttagctc tggtacctgg   4080

accagcagac ttagaagcga tagaagcgat gatttcagcg tagtgaactc tagcaactct   4140

tgaaacagca gcaaccattg ggatggtagc ttgaccacca caggtaacca tgttaacgtt   4200

taattggtca acgttagctt ccaagttaac aactggaaca cagtatggac cgatagcagc   4260

tggggtcaag tcgatcaatc tgatgtctgg cttagcttct ctcaaagcag cgtcgttctt   4320

aacgtgagca ccagcagagg tagcgtcgaa aacgatgtcg atgtcagcga attctggcat   4380

gttcatcaaa ccgataacac cttcgtgggt ggtagcaaca cccattcttc tagctctagc   4440

caaaccgtca gattgtgggt cgataccaac cataacagcc atttccaagt gttgaccgtg   4500

tcttaggatc ttgatcatca agtcagtacc gatgttacca gaaccgatga tagcaacctt   4560

tctcttagac atctgcagtc tagatatatt tgttgtaaaa agtagataat tacttccttg   4620

atgatctgta aaaaagagaa aaagaaagca tctaagaact tgaaaaacta cgaattagaa   4680

aagaccaaat atgtatttct tgcattgacc aatttatgca agtttatata tatgtaaatg   4740

taagtttcac gaggttctac taaactaaac cacccccttg gttagaagaa aagagtgtgt   4800

gagaacaggc tgttgttgtc acacgattcg gacaattctg tttgaaagag agagagtaac   4860

agtacgatcg aacgaacttt gctctggaga tcacagtggg catcatagca tgtggtacta   4920

aaccctttcc cgccattcca gaaccttcga ttgcttgtta caaaacctgt gagccgtcgc   4980

taggaccttg ttgtgtgacg aaattggaag ctgcaatcaa taggaagaca ggaagtcgag   5040

cgtgtctggg ttttttcagt tttgttcttt ttgcaaacaa atcacgagcg acggtaattt   5100

ctttctcgat aagaggccac gtgctttatg agggtaacat caattcaaga aggagggaaa   5160

cacttccttt ttctggccct gataatagta tgagggtgaa gccaaaataa aggattcgcg   5220

cccaaatcgg catctttaaa tgcaggtatg cgatagttcc tcactctttc cttactcacg   5280

agtaattctt gcaaatgcct attatgcaga tgttataata tctgtgcgtc ttgagttgaa   5340

gagctcgaga ctagtggatc ccccgggctg caggaattcg atatcaagct tatcgatacc   5400

gtcgacctcg agggggggcc cggtacccag cttttgttcc ctttagtgag ggttaattcc   5460

gagcttggcg taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat   5520

tccacacaac ataggagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag   5580

gtaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg   5640

ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc   5700

ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc   5760

agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa   5820

catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt   5880

tttccatagg ctcggccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg   5940

gcgaaacccg acaggactat aaagatacca ggcgttcccc cctggaagct ccctcgtgcg   6000

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag   6060

cgtggcgctt tctcaatgct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc   6120

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa   6180

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg   6240

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc   6300

taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac   6360

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg   6420

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt   6480

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt   6540

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa   6600

atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga   6660

ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac tgcccgtcgt   6720

gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa tgataccgcg   6780

agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg gaagggccga   6840

gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt gttgccggga   6900

agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca ttgctacagg   6960

catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt cccaacgatc   7020

aaggcgagtt acatgatccc ccatgttgtg aaaaaaagcg gttagctcct tcggtcctcc   7080

gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg cagcactgca   7140

taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg agtactcaac   7200

caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg   7260

ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa aacgttcttc   7320

ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt aacccactcg   7380

tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt gagcaaaaac   7440

aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt gaatactcat   7500

actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata   7560

catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa   7620

agtgccacct gacgtcttat tatcatgaca ttaacctata aaaataggcg tatcacgagg   7680

ccctttcgtc                                                          7690


<210>  42
<211>  9416
<212>  DNA
<213>  Artificial

<220>
<223>  pRN595

<400>  42
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataagacgtc     60

aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca    120

ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa    180

aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt    240

ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca    300

gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag    360

ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc    420

ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca    480

gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt    540

aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct    600

gacaacgatc ggaggaccga aggagctaac cgcttttttt cacaacatgg gggatcatgt    660

aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga    720

caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact    780

tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc    840

acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga    900

gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt    960

agttatctac acgacgggca gtcaggcaac tatggatgaa cgaaatagac agatcgctga   1020

gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact   1080

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga   1140

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt   1200

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca   1260

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct   1320

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta   1380

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct   1440

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc   1500

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca   1560

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agcattgaga   1620

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg   1680

aacaggagag cgcacgaggg agcttccagg ggggaacgcc tggtatcttt atagtcctgt   1740

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggccgag   1800

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt   1860

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt   1920

tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga   1980

ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta   2040

atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa   2100

tgtgagttac ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcctat   2160

gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta   2220

cgccaagctc ggaattaacc ctcactaaag ggaacaaaag ctgggtaccg ggccccccct   2280

cgaggtcgac ggtatcgata agcttgatat cgaattcctg cagcccgggg gatccactag   2340

tctcgagctc ttcaactcaa gacgcacaga tattataaca tctgcataat aggcatttgc   2400

aagaattact cgtgagtaag gaaagagtga ggaactatcg catacctgca tttaaagatg   2460

ccgatttggg cgcgaatcct ttattttggc ttcaccctca tactattatc agggccagaa   2520

aaaggaagtg tttccctcct tcttgaattg atgttaccct cataaagcac gtggcctctt   2580

atcgagaaag aaattaccgt cgctcgtgat ttgtttgcaa aaagaacaaa actgaaaaaa   2640

cccagacacg ctcgacttcc tgtcttccta ttgattgcag cttccaattt cgtcacacaa   2700

caaggtccta gcgacggctc acaggttttg taacaagcaa tcgaaggttc tggaatggcg   2760

ggaaagggtt tagtaccaca tgctatgatg cccactgtga tctccagagc aaagttcgtt   2820

cgatcgtact gttactctct ctctttcaaa cagaattgtc cgaatcgtgt gacaacaaca   2880

gcctgttctc acacactctt ttcttctaac caagggggtg gtttagttta gtagaacctc   2940

gtgaaactta catttacata tatataaact tgcataaatt ggtcaatgca agaaatacat   3000

atttggtctt ttctaattcg tagtttttca agttcttaga tgctttcttt ttctcttttt   3060

tacagatcat caaggaagta attatctact ttttacaaca aatatatcta gaaaatggct   3120

gttaccaacg ttgctgaatt gaacgctttg gttgaaaggg ttaagaaggc tcaaagagaa   3180

tacgcttctt tcacccaaga acaagttgac aagatcttca gagctgctgc tttggctgct   3240

gctgacgcta gaatcccatt ggctaagatg gctgttgctg aatctggtat gggtatcgtt   3300

gaagacaagg ttatcaagaa ccacttcgct tctgaataca tctacaacgc ttacaaggac   3360

gaaaagacct gtggtgtttt gtcagaagac gacaccttcg gtaccatcac catcgctgaa   3420

ccaatcggta tcatctgtgg tatcgttcca accaccaacc caacctctac cgctatcttc   3480

aagtctttga tctctttgaa gaccagaaac gctatcatct tctctccaca cccaagagct   3540

aaagacgcta ccaacaaggc tgctgacatc gttttgcaag ctgctatcgc tgctggtgct   3600

ccaaaggact tgatcggttg gatcgaccaa ccatctgttg aattgtctaa cgctttgatg   3660

caccacccag acatcaactt gatcttggct accggtggtc caggtatggt taaggctgct   3720

tactcttctg gtaagccagc tatcggtgtt ggtgctggta acaccccagt tgttatcgac   3780

gaaaccgctg acatcaagag agctgttgct tctgttttga tgtctaagac cttcgacaac   3840

ggtgttatct gtgcttctga acaatctgtt gttgttgttg actctgttta cgacgctgtt   3900

agagaaagat tcgctaccca cggtggttac ttgttgcaag gtaaggaatt gaaggctgtt   3960

caagacgtta tcttgaagaa cggtgctttg aacgctgcta tcgttggtca accagcttac   4020

aagatcgctg aattagctgg tttctctgtt ccagaaaaca ccaagatctt gatcggtgaa   4080

gttaccgttg ttgacgaatc tgaaccattc gctcacgaaa agttgtctcc aaccttggct   4140

atgtacagag ctaaggactt cgaagacgct gttgaaaaag ctgaaaagtt ggttgctatg   4200

ggtggtattg gtcacacctc ttgtttgtac accgaccaag acaaccaacc agctagagtt   4260

tcttacttcg gtcaaaagat gaagaccgct agaatcttga tcaacacccc agcttctcaa   4320

ggtggtatcg gtgacttgta caacttcaag ttggctccat ctttgacctt gggttgtggt   4380

tcttggggtg gtaactctat ctctgaaaac gttggtccaa agcacttgat caacaagaag   4440

accgttgcta agagagctga aaacatgttg tggcacaagt tgccaaaatc tatctacttc   4500

agaagaggtt ctttgccaat cgctttggac gaagttatca ccgacggtca caagagagct   4560

ttgatcgtta ccgacagatt cttgttcaac aacggttacg ctgaccaaat cacctctgtt   4620

ttgaaggctg ctggtgttga aaccgaagtt ttcttcgaag ttgaagctga cccaaccttg   4680

tctatcgtta gaaagggtgc tgaattggct aactctttca agccagacgt tatcatcgct   4740

ttgggtggtg gttctccaat ggacgctgct aagatcatgt gggttatgta cgaacaccca   4800

gaaacccact tcgaagaatt ggctttgaga ttcatggaca tcagaaagag aatctacaag   4860

ttcccaaaga tgggtgttaa ggctaagatg atcgctgtta ccaccacctc tggtaccggt   4920

tctgaagtta ccccattcgc tgttgttacc gacgacgcta ccggtcaaaa gtacccattg   4980

gctgactacg ctttgacccc agacatggct atcgttgacg ctaacttggt tatggacatg   5040

ccaaagtctt tgtgtgcttt cggtggtttg gacgctgtta cccacgctat ggaagcttac   5100

gtttctgttt tggcttctga attctctgac ggtcaagctt tgcaagcttt gaagttgttg   5160

aaggaatact tgccagcttc ttaccacgaa ggttctaaga acccagttgc tagagaaaga   5220

gttcactctg ctgctaccat cgctggtatc gctttcgcta acgctttctt gggtgtttgt   5280

cactctatgg ctcacaagtt gggttctcaa ttccacatcc cacacggttt ggctaacgct   5340

ttgttgatct gtaacgttat cagatacaac gctaacgaca acccaaccaa gcaaaccgct   5400

ttctctcaat acgacagacc acaagctaga agaagatacg ctgaaatcgc tgaccacttg   5460

ggtttgtctg ctccaggtga cagaaccgct gcaaagatcg aaaagttgtt ggcttggttg   5520

gaaaccttga aggctgaatt gggtatccca aagtctatca gagaagctgg tgttcaagaa   5580

gctgacttct tggctaacgt tgacaagttg tctgaagacg ctttcgacga ccaatgtacc   5640

ggtgctaacc caagataccc attgatctct gaattgaagc aaatcttgtt ggacacctac   5700

tacggtagag actacgttga aggtgaaacc gctgctaaga aggaagctgc tccagctaag   5760

gctgaaaaga aggctaagaa gtctgcttag cttaagcgcg cgaatttctt atgatttatg   5820

atttttatta ttaaataagt tataaaaaaa ataagtgtat acaaatttta aagtgactct   5880

taggttttaa aacgaaaatt cttattcttg agtaactctt tcctgtaggt caggttgctt   5940

tctcaggtat agcatgaggt cgctcttatt gaccacacct ctaccggcat gccgagcaaa   6000

tgcctgcaaa tcgctcccca tttcacccaa ttgtagatat gctaactcca gcaatgagtt   6060

gatgaatctc ggtgtgtatt ttatgtcctc agaggacaac acctgttgta atcgttcttc   6120

cacacgtacg aagcttaaaa gggcgaattc tgcagatatc catcacactg gcggccgcat   6180

gctagctccg gattatcgat gataagctgt caaagatgag aattaattcc acggactata   6240

gactatacta gatactccgt ctactgtacg atacacttcc gctcaggtcc ttgtccttta   6300

acgaggcctt accactcttt tgttactcta ttgatccagc tcagcaaagg cagtgtgatc   6360

taagattcta tcttcgcgat gtagtaaaac tagctagacc gagaaagaga ctagaaatgc   6420

aaaaggcact tctacaatgg ctgccatcat tattatccga tgtgacgctg cagcttctca   6480

atgatattcg aatacgcttt gaggagatac agcctaatat ccgacaaact gttttacaga   6540

tttacgatcg tacttgttac ccatcattga attttgaaca tccgaacctg ggagttttcc   6600

ctgaaacaga tagtatattt gaacctgtat aataatatat agtctagcgc tttacggaag   6660

acaatgtatg tatttcggtt cctggagaaa ctattgcatc tattgcatag gtaatcttgc   6720

acgtcgcatc cccggttcat tttctgcgtt tccatcttgc acttcaatag catatctttg   6780

ttaacgaagc atctgtgctt cattttgtag aacaaaaatg caacgcgaga gcgctaattt   6840

ttcaaacaaa gaatctgagc tgcattttta cagaacagaa atgcaacgcg aaagcgctat   6900

tttaccaacg aagaatctgt gcttcatttt tgtaaaacaa aaatgcaacg cgacgagagc   6960

gctaattttt caaacaaaga atctgagctg catttttaca gaacagaaat gcaacgcgag   7020

agcgctattt taccaacaaa gaatctatac ttcttttttg ttctacaaaa atgcatcccg   7080

agagcgctat ttttctaaca aagcatctta gattactttt tttctccttt gtgcgctcta   7140

taatgcagtc tcttgataac tttttgcact gtaggtccgt taaggttaga agaaggctac   7200

tttggtgtct attttctctt ccataaaaaa agcctgactc cacttcccgc gtttactgat   7260

tactagcgaa gctgcgggtg cattttttca agataaaggc atccccgatt atattctata   7320

ccgatgtgga ttgcgcatac tttgtgaaca gaaagtgata gcgttgatga ttcttcattg   7380

gtcagaaaat tatgaacggt ttcttctatt ttgtctctat atactacgta taggaaatgt   7440

ttacattttc gtattgtttt cgattcactc tatgaatagt tcttactaca atttttttgt   7500

ctaaagagta atactagaga taaacataaa aaatgtagag gtcgagttta gatgcaagtt   7560

caaggagcga aaggtggatg ggtaggttat atagggatat agcacagaga tatatagcaa   7620

agagatactt ttgagcaatg tttgtggaag cggtattcgc aatgccggct ttccccgtca   7680

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc   7740

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt   7800

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac   7860

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc   7920

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt   7980

aacgtttaca atttcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac   8040

cgcatatgat ccgtcgagtt caagagaaaa aaaaagaaaa agcaaaaaga aaaaaggaaa   8100

gcgcgcctcg ttcagaatga cacgtataga atgatgcatt accttgtcat cttcagtatc   8160

atactgttcg tatacatact tactgacatt cataggtata catatataca catgtatata   8220

tatcgtatgc tgcagcttta aataatcggt gtcactacat aagaacacct ttggtggagg   8280

gaacatcgtt ggtaccattg ggcgaggtgg cttctcttat ggcaaccgca agagccttga   8340

acgcactctc actacggtga tgatcattct tgcctcgcag acaatcaacg tggagggtaa   8400

ttctgctagc ctctgcaaag ctttcaagaa aatgcgggat catctcgcaa gagagatctc   8460

ctactttctc cctttgcaaa ccaagttcga caactgcgta cggcctgttc gaaagatcta   8520

ccaccgctct ggaaagtgcc tcatccaaag gcgcaaatcc tgatccaaac ctttttactc   8580

cacgcgccag tagggcctct ttaaaagctt gaccgagagc aatcccgcag tcttcagtgg   8640

tgtgatggtc gtctatgtgt aagtcaccaa tgcactcaac gattagcgac cagccggaat   8700

gcttggccag agcatgtatc atatggtcca gaaaccctat acctgtgtgg acgttaatca   8760

cttgcgattg tgtggcctgt tctgctactg cttctgcctc tttttctggg aagatcgagt   8820

gctctatcgc taggggacca ccctttaaag agatcgcaat ctgaatcttg gtttcatttg   8880

taatacgctt tactagggct ttctgctctg tcatctttgc cttcgtttat cttgcctgct   8940

cattttttag tatattcttc gaagaaatca cattacttta tataatgtat aattcattat   9000

gtgataatgc caatcgctaa gaaaaaaaaa gagtcatccg ctaggtggaa aaaaaaaaat   9060

gaaaatcatt accgaggcat aaaaaaatat agagtgtact agaggaggcc aagagtaata   9120

gaaaaagaaa attgcgggaa aggactgtgt tatgacttcc ctgactaatg ccgtgttcaa   9180

acgatacctg gcagtgactc ctagcgctca ccaagctctt aaaacggaat tatggtgcac   9240

tctcagtaca atctgctctg atgccgcata gttaagccag ccccgacacc cgccaacacc   9300

cgctgacgcg ccctgacggg cttgtctgct cccggcatcc gcttacagac aagctgtgac   9360

cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac gcgcga       9416


<210>  43
<211>  9352
<212>  DNA
<213>  Artificial

<220>
<223>  pRN596

<400>  43
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataagacgtc     60

aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca    120

ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa    180

aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt    240

ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca    300

gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag    360

ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc    420

ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca    480

gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt    540

aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct    600

gacaacgatc ggaggaccga aggagctaac cgcttttttt cacaacatgg gggatcatgt    660

aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga    720

caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact    780

tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc    840

acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga    900

gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt    960

agttatctac acgacgggca gtcaggcaac tatggatgaa cgaaatagac agatcgctga   1020

gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact   1080

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga   1140

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt   1200

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca   1260

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct   1320

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta   1380

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct   1440

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc   1500

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca   1560

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agcattgaga   1620

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg   1680

aacaggagag cgcacgaggg agcttccagg ggggaacgcc tggtatcttt atagtcctgt   1740

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggccgag   1800

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt   1860

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt   1920

tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga   1980

ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta   2040

atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa   2100

tgtgagttac ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcctat   2160

gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta   2220

cgccaagctc ggaattaacc ctcactaaag ggaacaaaag ctgggtaccg ggccccccct   2280

cgaggtcgac ggtatcgata agcttgatat cgaattcctg cagcccgggg gatccactag   2340

tctcgagctc ttcaactcaa gacgcacaga tattataaca tctgcataat aggcatttgc   2400

aagaattact cgtgagtaag gaaagagtga ggaactatcg catacctgca tttaaagatg   2460

ccgatttggg cgcgaatcct ttattttggc ttcaccctca tactattatc agggccagaa   2520

aaaggaagtg tttccctcct tcttgaattg atgttaccct cataaagcac gtggcctctt   2580

atcgagaaag aaattaccgt cgctcgtgat ttgtttgcaa aaagaacaaa actgaaaaaa   2640

cccagacacg ctcgacttcc tgtcttccta ttgattgcag cttccaattt cgtcacacaa   2700

caaggtccta gcgacggctc acaggttttg taacaagcaa tcgaaggttc tggaatggcg   2760

ggaaagggtt tagtaccaca tgctatgatg cccactgtga tctccagagc aaagttcgtt   2820

cgatcgtact gttactctct ctctttcaaa cagaattgtc cgaatcgtgt gacaacaaca   2880

gcctgttctc acacactctt ttcttctaac caagggggtg gtttagttta gtagaacctc   2940

gtgaaactta catttacata tatataaact tgcataaatt ggtcaatgca agaaatacat   3000

atttggtctt ttctaattcg tagtttttca agttcttaga tgctttcttt ttctcttttt   3060

tacagatcat caaggaagta attatctact ttttacaaca aatatatcta gaaaatgtct   3120

acccaacaaa ccatgaccgt tgacgaacac atcaaccaat tagttagaaa ggctcaagtt   3180

gctttgaagg aatacttgaa gccagaatac acccaagaaa agatcgacta catcgttaag   3240

aaggcttctg ttgctgcttt ggaccaacac tgtgctttgg ctgctgctgc tgttgaagaa   3300

accggtagag gtatcttcga agacaaggct accaagaaca tcttcgcttg tgaacacgtt   3360

acccacgaaa tgagacacgc taagaccgtt ggtatcatca acgttgaccc attgtacggt   3420

atcaccgaaa tcgctgaacc agttggtgtt gtttgtggtg ttaccccagt taccaaccca   3480

acctctaccg ctatcttcaa gtctttgatc tctatcaaga ccagaaaccc aatcgttttc   3540

tctttccacc catctgcttt gaagtgttct attatggctg ctaaaatcgt tagagacgct   3600

gctatcgctg ctggtgctcc agaaaactgt atccaatgga tcgaattcgg tggtatcgaa   3660

gcttctaaca agttgatgaa ccacccaggt gttgctacta tcttggctac cggtggtaac   3720

gctatggtta aggctgcata ctcttctggt aagccagctt tgggtgttgg tgctggtaac   3780

gttccaacct acatcgaaaa gacctgtaac atcaagcaag ctgctaacga cgttgttatg   3840

tctaagtctt tcgacaacgg tatgatctgt gcttctgaac aagctgctat catcgacaag   3900

gaaatctacg accaagttgt tgaagaaatg aagaccttgg gtgcttactt catcaacgaa   3960

gaagaaaagg ctaagttgga aaagttcatg ttcggtgtta acgcttactc tgctgacgtt   4020

aacaacgcta gattgaaccc aaagtgtcca ggtatgtctc cacaatggtt cgctgaacaa   4080

gttggtatca aggtaccaga agactgtaac atcatctgtg ctgtttgtaa ggaagttggt   4140

ccaaacgaac cattgaccag agaaaagttg tctccagttt tggctatctt gaaagctgaa   4200

aacacccaag acggtatcga caaggctgaa gctatggttg aatttaacgg tagaggtcac   4260

tctgctgcta tccactctaa cgacaaggct gttgttgaaa agtacgcttt gaccatgaag   4320

gcttgtagaa tcttgcacaa caccccatct tctcaaggtg gtatcggttc tatctacaac   4380

tacatctggc catctttcac cttgggttgt ggttcttacg gtggtaactc tgtttctgct   4440

aacgttacct accacaactt gttgaacatc aagagattgg ctgacagaag aaacaacttg   4500

caatggttca gagttccacc aaagatcttc ttcgaaccac actctatcag atacttggct   4560

gaattgaagg aattgtctaa gatcttcatc gtttctgaca gaatgatgta caagttgggt   4620

tacgttgaca gagttatgga cgttttgaag agaagatcta acgaagttga aatcgaaatc   4680

ttcatcgacg ttgaaccaga cccatctatc caaaccgttc aaaagggttt ggctgttatg   4740

aacaccttcg gtccagacaa catcatcgct atcggtggtg gttctgctat ggacgctgct   4800

aagatcatgt ggttgttgta cgaacaccca gaagctgact tcttcgctat gaagcaaaag   4860

ttcatcgact tgagaaagag agctttcaag ttcccaacca tgggtaagaa ggctagattg   4920

atctgtatcc caaccacctc tggtaccggt tctgaagtta ccccattcgc tgttatctct   4980

gaccacgaaa ccggtaagaa gtacccattg gctgactact ctttgacccc atctgttgct   5040

atcgttgacc caatgttcac catgtctttg ccaaagagag ctatcgctga caccggtttg   5100

gacgttttgg ttcacgctac cgaagcttac gtttctgtta tggctaacga atacaccgac   5160

ggtttggcta gagaagctgt taagttggtt tttgaaaact tgttgaagtc ttacaacggt   5220

gacttggaag ctagagaaaa gatgcacaac gctgctacca tcgctggtat ggctttcgct   5280

tctgctttct tgggtatgga ccactctatg gctcacaagg ttggtgctgc tttccacttg   5340

ccacacggta gatgtgttgc tgttttgttg ccacacgtta tcagatacaa cggtcaaaag   5400

ccaagaaagt tggctatgtg gccaaagtac aacttctaca aggctgacca aagatacatg   5460

gaattggctc aaatggttgg tttgaagtgt aacaccccag ctgaaggtgt tgaagctttc   5520

gctaaggctt gtgaagaatt gatgaaggct accgaaacca tcaccggttt caagaaggct   5580

aacatcgacg aagctgcttg gatgtctaag gttccagaaa tggctttgtt ggctttcgaa   5640

gaccaatgtt ctccagctaa cccaagagtt ccaatggtta aggacatgga aaagatcttg   5700

aaggctgctt actacccaat cgcttagctt aagcgcgcga atttcttatg atttatgatt   5760

tttattatta aataagttat aaaaaaaata agtgtataca aattttaaag tgactcttag   5820

gttttaaaac gaaaattctt attcttgagt aactctttcc tgtaggtcag gttgctttct   5880

caggtatagc atgaggtcgc tcttattgac cacacctcta ccggcatgcc gagcaaatgc   5940

ctgcaaatcg ctccccattt cacccaattg tagatatgct aactccagca atgagttgat   6000

gaatctcggt gtgtatttta tgtcctcaga ggacaacacc tgttgtaatc gttcttccac   6060

acgtacgaag ctaaaagggc gaattctgca gatatccatc acactggcgg ccgcatgcta   6120

gctccggatt atcgatgata agctgtcaaa gatgagaatt aattccacgg actatagact   6180

atactagata ctccgtctac tgtacgatac acttccgctc aggtccttgt cctttaacga   6240

ggccttacca ctcttttgtt actctattga tccagctcag caaaggcagt gtgatctaag   6300

attctatctt cgcgatgtag taaaactagc tagaccgaga aagagactag aaatgcaaaa   6360

ggcacttcta caatggctgc catcattatt atccgatgtg acgctgcagc ttctcaatga   6420

tattcgaata cgctttgagg agatacagcc taatatccga caaactgttt tacagattta   6480

cgatcgtact tgttacccat cattgaattt tgaacatccg aacctgggag ttttccctga   6540

aacagatagt atatttgaac ctgtataata atatatagtc tagcgcttta cggaagacaa   6600

tgtatgtatt tcggttcctg gagaaactat tgcatctatt gcataggtaa tcttgcacgt   6660

cgcatccccg gttcattttc tgcgtttcca tcttgcactt caatagcata tctttgttaa   6720

cgaagcatct gtgcttcatt ttgtagaaca aaaatgcaac gcgagagcgc taatttttca   6780

aacaaagaat ctgagctgca tttttacaga acagaaatgc aacgcgaaag cgctatttta   6840

ccaacgaaga atctgtgctt catttttgta aaacaaaaat gcaacgcgac gagagcgcta   6900

atttttcaaa caaagaatct gagctgcatt tttacagaac agaaatgcaa cgcgagagcg   6960

ctattttacc aacaaagaat ctatacttct tttttgttct acaaaaatgc atcccgagag   7020

cgctattttt ctaacaaagc atcttagatt actttttttc tcctttgtgc gctctataat   7080

gcagtctctt gataactttt tgcactgtag gtccgttaag gttagaagaa ggctactttg   7140

gtgtctattt tctcttccat aaaaaaagcc tgactccact tcccgcgttt actgattact   7200

agcgaagctg cgggtgcatt ttttcaagat aaaggcatcc ccgattatat tctataccga   7260

tgtggattgc gcatactttg tgaacagaaa gtgatagcgt tgatgattct tcattggtca   7320

gaaaattatg aacggtttct tctattttgt ctctatatac tacgtatagg aaatgtttac   7380

attttcgtat tgttttcgat tcactctatg aatagttctt actacaattt ttttgtctaa   7440

agagtaatac tagagataaa cataaaaaat gtagaggtcg agtttagatg caagttcaag   7500

gagcgaaagg tggatgggta ggttatatag ggatatagca cagagatata tagcaaagag   7560

atacttttga gcaatgtttg tggaagcggt attcgcaatg ccggctttcc ccgtcaagct   7620

ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa   7680

aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc   7740

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca   7800

ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat   7860

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg   7920

tttacaattt cctgatgcgg tattttctcc ttacgcatct gtgcggtatt tcacaccgca   7980

tatgatccgt cgagttcaag agaaaaaaaa agaaaaagca aaaagaaaaa aggaaagcgc   8040

gcctcgttca gaatgacacg tatagaatga tgcattacct tgtcatcttc agtatcatac   8100

tgttcgtata catacttact gacattcata ggtatacata tatacacatg tatatatatc   8160

gtatgctgca gctttaaata atcggtgtca ctacataaga acacctttgg tggagggaac   8220

atcgttggta ccattgggcg aggtggcttc tcttatggca accgcaagag ccttgaacgc   8280

actctcacta cggtgatgat cattcttgcc tcgcagacaa tcaacgtgga gggtaattct   8340

gctagcctct gcaaagcttt caagaaaatg cgggatcatc tcgcaagaga gatctcctac   8400

tttctccctt tgcaaaccaa gttcgacaac tgcgtacggc ctgttcgaaa gatctaccac   8460

cgctctggaa agtgcctcat ccaaaggcgc aaatcctgat ccaaaccttt ttactccacg   8520

cgccagtagg gcctctttaa aagcttgacc gagagcaatc ccgcagtctt cagtggtgtg   8580

atggtcgtct atgtgtaagt caccaatgca ctcaacgatt agcgaccagc cggaatgctt   8640

ggccagagca tgtatcatat ggtccagaaa ccctatacct gtgtggacgt taatcacttg   8700

cgattgtgtg gcctgttctg ctactgcttc tgcctctttt tctgggaaga tcgagtgctc   8760

tatcgctagg ggaccaccct ttaaagagat cgcaatctga atcttggttt catttgtaat   8820

acgctttact agggctttct gctctgtcat ctttgccttc gtttatcttg cctgctcatt   8880

ttttagtata ttcttcgaag aaatcacatt actttatata atgtataatt cattatgtga   8940

taatgccaat cgctaagaaa aaaaaagagt catccgctag gtggaaaaaa aaaaatgaaa   9000

atcattaccg aggcataaaa aaatatagag tgtactagag gaggccaaga gtaatagaaa   9060

aagaaaattg cgggaaagga ctgtgttatg acttccctga ctaatgccgt gttcaaacga   9120

tacctggcag tgactcctag cgctcaccaa gctcttaaaa cggaattatg gtgcactctc   9180

agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct   9240

gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc   9300

tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc ga           9352


<210>  44
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Primer GPD2uf

<400>  44
ggtaccagat cttttgcggc gaggtgccg                                       29


<210>  45
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Primer GPD2ur

<400>  45
tctagactta aggaatgtgt atcttgttaa tcttctgaca gc                        42


<210>  46
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Primer GPD2df

<400>  46
ctcgagatag tctacaacaa cgtccgca                                        28


<210>  47
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Primer GPD2dr

<400>  47
ccatggagat ctgcagtgaa aaagctcgaa gaaacagct                            39


<210>  48
<211>  4397
<212>  DNA
<213>  Artificial

<220>
<223>  pRN594

<400>  48
gacgacggcg acctggcggg cttcgtggtc gtctcgtact ccggctggaa ccgccggctg     60

accgtcgagg acatcgaggt cgccccggag caccgggggc acggggtcgg gcgcgcgttg    120

atggggctcg cgacggagtt cgcccgcgag cggggcgccg ggcacctctg gctggaggtc    180

accaacgtca acgcaccggc gatccacgcg taccggcgga tggggttcac cctctgcggc    240

ctggacaccg ccctgtacga cggcaccgcc tcggacggcg agcaggcgct ctacatgagc    300

atgccctgcc cctagtactg acaataaaaa gattcttgtt ttcaagaact tgtcatttgt    360

atagtttttt tatattgtag ttgttctatt ttaatcaaat gttagcgtga tttatatttt    420

ttttcgcctc gacatcatct gcccagatgc gaagttaagt gcgcagaaag taatatcatg    480

cgtcaatcgt atgtgaatgc tggtcgctat actgctgtcg attcgatact aacgccgcca    540

tccagtgtcg acggatccta ggtgtacagg gcccaaaagg gcgaattctg cagatatcca    600

tcacactggc ggccgctcga gatagtctac aacaacgtcc gcatggaaga cctaccggag    660

atgattgaag agctagacat cgatgacgaa tagacactct ccccccccct ccccctctga    720

tctttcctgt tgcctctttt tcccccaacc aatttatcat tatacacaag ttctacaact    780

actactagta acattactac agttattata attttctatt ctctttttct ttaagaatct    840

atcattaacg ttaatttcta tatatacata actaccatta tacacgctat tatcgtttac    900

atatcacatc accgttaatg aaagatacga caccctgtac actaacacaa ttaaataatc    960

gccataacct tttctgttat ctatagccct taaagctgtt tcttcgagct ttttcactgc   1020

agatctccat ggcgatgcct gcttgccgaa tatcatggtg gaaaatggcc gcttttctgg   1080

attcatcgac tgtggccggc tgggtgtggc ggaccgctat caggacatag cgttggctac   1140

ccgtgatatt gctgaagagc ttggcggcga atgggctgac cgcttcctcg tgctttacgg   1200

tatcgccgct cccgattcgc agcgcatcgc cttctatcgc cttcttgacg agttcttctg   1260

aattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt   1320

gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct   1380

gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc   1440

cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta   1500

tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac   1560

tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc   1620

atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac   1680

ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg   1740

gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac   1800

gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc   1860

gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt   1920

gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga   1980

gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc   2040

cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag   2100

atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca   2160

tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc   2220

ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca   2280

gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc   2340

tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta   2400

ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgttctt   2460

ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc   2520

gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg   2580

ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg   2640

tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag   2700

ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc   2760

agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat   2820

agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg   2880

gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc   2940

tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt   3000

accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca   3060

gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg   3120

attcattaat gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac   3180

gcaattaatg tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg   3240

gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc acacaggaaa cagctatgac   3300

catgattacg ccaagctatt taggtgacac tatagaatac tcaagctatg catcaagctt   3360

ggtaccagat cttttgcggc gaggtgccga tgggttgctg aggggaagag tgtttagctt   3420

acggacctat tgccattgtt attccgatta atctattgtt cagcagctct tctctaccct   3480

gtcattctag tatttttttt tttttttttt ggttttactt ttttttcttc ttgccttttt   3540

ttcttgttac tttttttcta gttttttttc cttccactaa gctttttcct tgatttatcc   3600

ttgggttctt ctttctactc ctttagattt tttttttata tattaatttt taagtttatg   3660

tattttggta gattcaattc tctttccctt tccttttcct tcgctcccct tccttatcaa   3720

tgcttgctgt cagaagatta acaagataca cattccttaa ggcctcgtcc ccgccgggtc   3780

acccggccag cgacatggag gcccagaata ccctccttga cagtcttgac gtgcgcagct   3840

caggggcatg atgtgactgt cgcccgtaca tttagcccat acatccccat gtataatcat   3900

ttgcatccat acattttgat ggccgcacgg cgcgaagcaa aaattacggc tcctcgctgc   3960

agacctgcga gcagggaaac gctcccctca cagacgcgtt gaattgtccc cacgccgcgc   4020

ccctgtagag aaatataaaa ggttaggatt tgccactgag gttcttcttt catatacttc   4080

cttttaaaat cttgctagga tacagttctc acatcacatc cgaacataaa caaccatgta   4140

aaatgaccac tcttgacgac acggcttacc ggtaccgcac cagtgtcccg ggggacgccg   4200

aggccatcga ggcactggat gggtccttca ccaccgacac cgtcttccgc gtcaccgcca   4260

ccggggacgg cttcaccctg cgggaggtgc cggtggaccc gcccctgacc aaggtgttcc   4320

ccgacgacga atcggacgac gaatcggacg ccggggagga cggcgacccg gactcccgga   4380

cgttcgtcgc gtacggg                                                  4397


<210>  49
<211>  367
<212>  PRT
<213>  Escherichia coli

<400>  49

Met Asp Arg Ile Ile Gln Ser Pro Gly Lys Tyr Ile Gln Gly Ala Asp 
1               5                   10                  15      


Val Ile Asn Arg Leu Gly Glu Tyr Leu Lys Pro Leu Ala Glu Arg Trp 
            20                  25                  30          


Leu Val Val Gly Asp Lys Phe Val Leu Gly Phe Ala Gln Ser Thr Val 
        35                  40                  45              


Glu Lys Ser Phe Lys Asp Ala Gly Leu Val Val Glu Ile Ala Pro Phe 
    50                  55                  60                  


Gly Gly Glu Cys Ser Gln Asn Glu Ile Asp Arg Leu Arg Gly Ile Ala 
65                  70                  75                  80  


Glu Thr Ala Gln Cys Gly Ala Ile Leu Gly Ile Gly Gly Gly Lys Thr 
                85                  90                  95      


Leu Asp Thr Ala Lys Ala Leu Ala His Phe Met Gly Val Pro Val Ala 
            100                 105                 110         


Ile Ala Pro Thr Ile Ala Ser Thr Asp Ala Pro Cys Ser Ala Leu Ser 
        115                 120                 125             


Val Ile Tyr Thr Asp Glu Gly Glu Phe Asp Arg Tyr Leu Leu Leu Pro 
    130                 135                 140                 


Asn Asn Pro Asn Met Val Ile Val Asp Thr Lys Ile Val Ala Gly Ala 
145                 150                 155                 160 


Pro Ala Arg Leu Leu Ala Ala Gly Ile Gly Asp Ala Leu Ala Thr Trp 
                165                 170                 175     


Phe Glu Ala Arg Ala Cys Ser Arg Ser Gly Ala Thr Thr Met Ala Gly 
            180                 185                 190         


Gly Lys Cys Thr Gln Ala Ala Leu Ala Leu Ala Glu Leu Cys Tyr Asn 
        195                 200                 205             


Thr Leu Leu Glu Glu Gly Glu Lys Ala Met Leu Ala Ala Glu Gln His 
    210                 215                 220                 


Val Val Thr Pro Ala Leu Glu Arg Val Ile Glu Ala Asn Thr Tyr Leu 
225                 230                 235                 240 


Ser Gly Val Gly Phe Glu Ser Gly Gly Leu Ala Ala Ala His Ala Val 
                245                 250                 255     


His Asn Gly Leu Thr Ala Ile Pro Asp Ala His His Tyr Tyr His Gly 
            260                 265                 270         


Glu Lys Val Ala Phe Gly Thr Leu Thr Gln Leu Val Leu Glu Asn Ala 
        275                 280                 285             


Pro Val Glu Glu Ile Glu Thr Val Ala Ala Leu Ser His Ala Val Gly 
    290                 295                 300                 


Leu Pro Ile Thr Leu Ala Gln Leu Asp Ile Lys Glu Asp Val Pro Ala 
305                 310                 315                 320 


Lys Met Arg Ile Val Ala Glu Ala Ala Cys Ala Glu Gly Glu Thr Ile 
                325                 330                 335     


His Asn Met Pro Gly Gly Ala Thr Pro Asp Gln Val Tyr Ala Ala Leu 
            340                 345                 350         


Leu Val Ala Asp Gln Tyr Gly Gln Arg Phe Leu Gln Glu Trp Glu 
        355                 360                 365         


<210>  50
<211>  1120
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide seqeunce encoding E.coli gldA codon-optimised for 
       yeast

<400>  50
ctgcagaaaa tggacagaat catccaatct ccaggtaagt acatccaagg tgctgacgtt     60

atcaacagat tgggtgaata cttgaagcca ttggctgaaa gatggttggt tgttggtgac    120

aagttcgttt tgggtttcgc tcaatctacc gttgaaaagt ctttcaagga cgctggtttg    180

gttgttgaaa tcgctccatt cggtggtgaa tgttctcaaa acgaaatcga cagattgaga    240

ggtatcgctg aaaccgctca atgtggtgct atcttgggta tcggtggtgg taagaccttg    300

gacaccgcta aggctttggc tcacttcatg ggtgttccag ttgctatcgc tccaaccatc    360

gcttctaccg acgctccatg ttctgctttg tctgttatct acaccgacga aggtgaattc    420

gacagatact tgttgttgcc aaacaaccca aacatggtta tcgttgacac caagatcgtt    480

gctggtgctc cagctagatt gttggcagct ggtatcggtg acgctttggc tacctggttc    540

gaagctagag cttgttctag atctggtgct accaccatgg ctggtggtaa gtgtacccaa    600

gctgctttgg ctttggctga attgtgttac aacaccttgt tggaagaagg tgaaaaggct    660

atgttggctg ctgaacaaca cgttgttacc ccagctttgg aaagagttat cgaagctaac    720

acctacttgt ctggtgttgg tttcgaatct ggtggtttgg ctgctgctca cgctgttcac    780

aacggtttga ccgctatccc agacgctcac cactactacc acggtgaaaa ggttgctttc    840

ggtaccttga cccaattggt tttggaaaac gctccagttg aagaaatcga aaccgttgct    900

gctttgtctc acgctgttgg tttgccaatc accttggctc aattggacat caaggaagac    960

gttccagcta agatgagaat cgttgctgaa gctgcttgtg ctgaaggtga aaccatccac   1020

aacatgccag gtggtgctac cccagaccaa gtttacgctg ctttgttggt tgctgaccaa   1080

tacggtcaaa gattcctaca agaatgggaa taaggcgcgc                         1120


<210>  51
<211>  1949
<212>  DNA
<213>  Artificial

<220>
<223>  pRNgldA

<400>  51
actagtaaat gtgtggggaa gcgggtaagc tgccacagca attaatgcac aacatttaac     60

ctacattctt ccttatcgga tcctcaaaac ccttaaaaac atatgcctca ccctaacata    120

ttttccaatt aaccctcaat atttctctgt cacccggcct ctattttcca ttttcttctt    180

tacccgccac gcgttttttt ctttcaaatt tttttcttcc ttcttctttt tcttccacgt    240

cctcttgcat aaataaataa accgttttga aaccaaactc gcctctctct ctcctttttg    300

aaatattttt gggtttgttt gatcctttcc ttcccaatct ctcttgttta atatatattc    360

atttatatca cgctctcttt ttatcttcct ttttttcctc tctcttgtat tcttccttcc    420

cctttctact caaaccaaga agaaaaagaa aaggtcaatc tttgttaaag aataggatct    480

tctactacat cagcttttag atttttcacg cttactgctt ttttcttccc aagatcgaaa    540

atttactgaa ttaactgcag aaaatggaca gaatcatcca atctccaggt aagtacatcc    600

aaggtgctga cgttatcaac agattgggtg aatacttgaa gccattggct gaaagatggt    660

tggttgttgg tgacaagttc gttttgggtt tcgctcaatc taccgttgaa aagtctttca    720

aggacgctgg tttggttgtt gaaatcgctc cattcggtgg tgaatgttct caaaacgaaa    780

tcgacagatt gagaggtatc gctgaaaccg ctcaatgtgg tgctatcttg ggtatcggtg    840

gtggtaagac cttggacacc gctaaggctt tggctcactt catgggtgtt ccagttgcta    900

tcgctccaac catcgcttct accgacgctc catgttctgc tttgtctgtt atctacaccg    960

acgaaggtga attcgacaga tacttgttgt tgccaaacaa cccaaacatg gttatcgttg   1020

acaccaagat cgttgctggt gctccagcta gattgttggc agctggtatc ggtgacgctt   1080

tggctacctg gttcgaagct agagcttgtt ctagatctgg tgctaccacc atggctggtg   1140

gtaagtgtac ccaagctgct ttggctttgg ctgaattgtg ttacaacacc ttgttggaag   1200

aaggtgaaaa ggctatgttg gctgctgaac aacacgttgt taccccagct ttggaaagag   1260

ttatcgaagc taacacctac ttgtctggtg ttggtttcga atctggtggt ttggctgctg   1320

ctcacgctgt tcacaacggt ttgaccgcta tcccagacgc tcaccactac taccacggtg   1380

aaaaggttgc tttcggtacc ttgacccaat tggttttgga aaacgctcca gttgaagaaa   1440

tcgaaaccgt tgctgctttg tctcacgctg ttggtttgcc aatcaccttg gctcaattgg   1500

acatcaagga agacgttcca gctaagatga gaatcgttgc tgaagctgct tgtgctgaag   1560

gtgaaaccat ccacaacatg ccaggtggtg ctaccccaga ccaagtttac gctgctttgt   1620

tggttgctga ccaatacggt caaagattcc tacaagaatg ggaataaggc gcgccccttt   1680

tcctttgtcg atatcatgta attagttatg tcacgcttac attcacgccc tcctcccaca   1740

tccgctctaa ccgaaaagga aggagttaga caacctgaag tctaggtccc tatttatttt   1800

ttttaatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt cttttttttc   1860

tgtacaaacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag aaggttttgg   1920

gacgctcgaa ggcttcctag gcgtacgtt                                     1949


<210>  52
<211>  552
<212>  PRT
<213>  Citrobacter freundii

<400>  52

Met Ser Gln Phe Phe Phe Asn Gln Arg Thr His Leu Val Ser Asp Val 
1               5                   10                  15      


Ile Asp Gly Thr Ile Ile Ala Ser Pro Trp Asn Asn Leu Ala Arg Leu 
            20                  25                  30          


Glu Ser Asp Pro Ala Ile Arg Ile Val Val Arg Arg Asp Leu Asn Lys 
        35                  40                  45              


Asn Asn Val Ala Val Ile Ser Gly Gly Gly Ser Gly His Glu Pro Ala 
    50                  55                  60                  


His Val Gly Phe Ile Gly Lys Gly Met Leu Thr Ala Ala Val Cys Gly 
65                  70                  75                  80  


Asp Val Phe Ala Ser Pro Ser Val Asp Ala Val Leu Thr Ala Ile Gln 
                85                  90                  95      


Ala Val Thr Gly Glu Ala Gly Cys Leu Leu Ile Val Lys Asn Tyr Thr 
            100                 105                 110         


Gly Asp Arg Leu Asn Phe Gly Leu Ala Ala Glu Lys Ala Arg Arg Leu 
        115                 120                 125             


Gly Tyr Asn Val Glu Met Leu Ile Val Gly Asp Asp Ile Ser Leu Pro 
    130                 135                 140                 


Asp Asn Lys His Pro Arg Gly Ile Ala Gly Thr Ile Leu Val His Lys 
145                 150                 155                 160 


Ile Ala Gly Tyr Phe Ala Glu Arg Gly Tyr Asn Leu Ala Thr Val Leu 
                165                 170                 175     


Arg Glu Ala Gln Tyr Ala Ala Asn Asn Thr Phe Ser Leu Gly Val Ala 
            180                 185                 190         


Leu Ser Ser Cys His Leu Pro Gln Glu Ala Asp Ala Ala Pro Arg His 
        195                 200                 205             


His Pro Gly His Ala Glu Leu Gly Met Gly Ile His Gly Glu Pro Gly 
    210                 215                 220                 


Ala Ser Val Ile Asp Thr Gln Asn Ser Ala Gln Val Val Asn Leu Met 
225                 230                 235                 240 


Val Asp Lys Leu Met Ala Ala Leu Pro Glu Thr Gly Arg Leu Ala Val 
                245                 250                 255     


Met Ile Asn Asn Leu Gly Gly Val Ser Val Ala Glu Met Ala Ile Ile 
            260                 265                 270         


Thr Arg Glu Leu Ala Ser Ser Pro Leu His Pro Arg Ile Asp Trp Leu 
        275                 280                 285             


Ile Gly Pro Ala Ser Leu Val Thr Ala Leu Asp Met Lys Ser Phe Ser 
    290                 295                 300                 


Leu Thr Ala Ile Val Leu Glu Glu Ser Ile Glu Lys Ala Leu Leu Thr 
305                 310                 315                 320 


Glu Val Glu Thr Ser Asn Trp Pro Thr Pro Val Pro Pro Arg Glu Ile 
                325                 330                 335     


Ser Cys Val Pro Ser Ser Gln Arg Ser Ala Arg Val Glu Phe Gln Pro 
            340                 345                 350         


Ser Ala Asn Ala Met Val Ala Gly Ile Val Glu Leu Val Thr Thr Thr 
        355                 360                 365             


Leu Ser Asp Leu Glu Thr His Leu Asn Ala Leu Asp Ala Lys Val Gly 
    370                 375                 380                 


Asp Gly Asp Thr Gly Ser Thr Phe Ala Ala Gly Ala Arg Glu Ile Ala 
385                 390                 395                 400 


Ser Leu Leu His Arg Gln Gln Leu Pro Leu Asp Asn Leu Ala Thr Leu 
                405                 410                 415     


Phe Ala Leu Ile Gly Glu Arg Leu Thr Val Val Met Gly Gly Ser Ser 
            420                 425                 430         


Gly Val Leu Met Ser Ile Phe Phe Thr Ala Ala Gly Gln Lys Leu Glu 
        435                 440                 445             


Gln Gly Ala Ser Val Ala Glu Ser Leu Asn Thr Gly Leu Ala Gln Met 
    450                 455                 460                 


Lys Phe Tyr Gly Gly Ala Asp Glu Gly Asp Arg Thr Met Ile Asp Ala 
465                 470                 475                 480 


Leu Gln Pro Ala Leu Thr Ser Leu Leu Thr Gln Pro Gln Asn Leu Gln 
                485                 490                 495     


Ala Ala Phe Asp Ala Ala Gln Ala Gly Ala Glu Arg Thr Cys Leu Ser 
            500                 505                 510         


Ser Lys Ala Asn Ala Gly Arg Ala Ser Tyr Leu Ser Ser Glu Ser Leu 
        515                 520                 525             


Leu Gly Asn Met Asp Pro Gly Ala His Ala Val Ala Met Val Phe Lys 
    530                 535                 540                 


Ala Leu Ala Glu Ser Glu Leu Gly 
545                 550         


<210>  53
<211>  1678
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding the C. freundii dhaK codon-optimised
       for yeast

<400>  53
tctagaaaaa tgtctcaatt cttcttcaac cagagaaccc acttggtttc tgacgttatc     60

gacggtgcta tcatcgcttc accatggaac aatttggcta gattggaatc tgacccagct    120

atcagaatcg ttgttagaag agacttgaac aagaacaacg ttgctgttat ctctggtggt    180

ggttctggtc acgaaccagc tcacgttggt ttcatcggta agggtatgtt gaccgctgct    240

gtttgtggtg acgttttcgc ttctccatct gttgacgctg ttttgactgc tatccaagct    300

gttaccggtg aagctggttg tttgttgatc gttaagaact acaccggtga cagattgaac    360

ttcggtttgg ctgctgaaaa ggctagaaga ttgggttaca acgttgaaat gttgatcgtt    420

ggtgacgaca tctctttgcc agacaacaag cacccaagag gtatcgctgg taccatcttg    480

gttcacaaga tcgctggtta cttcgctgaa agaggttaca acttagctac cgttttgaga    540

gaagctcaat acgctgcttc taacaccttc tctttgggtg ttgctttgtc ttcttgtcac    600

ttgccacaag aaaccgacgc tgctccaaga caccacccag gtcacgctga attgggtatg    660

ggtatccacg gtgaaccagg tgcttctgtt atcgacaccc aaaactctgc tcaagttgtt    720

aacttgatgg ttgacaagtt gttggctgct ttgccagaaa ccggtagatt ggctgttatg    780

atcaacaact tgggtggtgt ttctgttgct gaaatggcta tcatcaccag agaattggct    840

tcttctccat tgcactcaag aatcgactgg ttgatcggtc cagcttcttt ggtaaccgct    900

ttggacatga agggtttctc tttgaccgct atcgttttgg aagaatctat cgaaaaggct    960

ttgttgaccg aagttgaaac ctctaactgg ccaaccccag ttccaccaag agaaatcacc   1020

tgtgttgttt cttctcacgc ttctgctaga gttgaattcc aaccatctgc taacgctttg   1080

gttgctggta tcgttgaatt ggttaccgct accttgtctg acttggaaac ccacttgaac   1140

gctttggacg ctaaggttgg tgacggtgac accggttcta ccttcgctgc tgctgctaga   1200

gaaatcgctt ctttgttgca cagacaacaa ttgccattga acaacttggc taccttgttc   1260

gctttgatcg gtgaaagatt gaccgttgtt atgggtggtt cttctggtgt tttgatgtct   1320

atcttcttca ccgctgctgg tcaaaagttg gaacaaggtg ctaacgttgt tgaagctttg   1380

aacaccggtt tggctcaaat gaagttctac ggtggtgctg acgaaggtga cagaaccatg   1440

atcgacgctt tgcaaccagc tttgacctct ttgttggctc aaccaaagaa cttgcaagct   1500

gctttcgacg ctgctcaagc tggtgctgaa agaacctgtt tgtcttctaa ggctaacgct   1560

ggtagagctt cttacttgtc ttctgaatct ttgttgggta acatggaccc aggtgctcaa   1620

agattggcta tggttttcaa ggctttggct gaatctgaat tgggttaata aggtcgac     1678


<210>  54
<211>  2951
<212>  DNA
<213>  Artificial

<220>
<223>  pRNdhaK

<400>  54
ggatccacta gtaacggccg ccagtgtgct ggaattcgcc cttctcgagc ttaagacgcg     60

tttcttcttc agattccctc atggagaaag tgcggcagat gtatatgaca gagtcgccag    120

tttccaagag actttattca ggcacttcca tgataggcaa gagagaagac ccagagatgt    180

tgttgtccta gttacacatg gtatttattc cagagtattc ctgatgaaat ggtttagatg    240

gacatacgaa gagtttgaat cgtttaccaa tgttcctaac gggagcgtaa tggtgatgga    300

actggacgaa tccatcaata gatacgtcct gaggaccgtg ctacccaaat ggactgattg    360

tgagggagac ctaactacat agtgtttaaa gattacggat atttaactta cttagaataa    420

tgccattttt ttgagttata ataatcctac gttagtgtga gcgggattta aactgtgagg    480

accttaatac attcagacac ttctgcggta tcaccctact tattcccttc gagattatat    540

ctaggaaccc atcaggttgg tggaagatta cccgttctaa gacttttcag cttcctctat    600

tgatgttaca cctggacacc ccttttctgg catccagttt ttaatcttca gtggcatgtg    660

agattctccg aaattaatta aagcaatcac acaattctct cggataccac ctcggttgaa    720

actgacaggt ggtttgttac gcatgctaat gcaaaggagc ctatatacct ttggctcggc    780

tgctgtaaca gggaatataa agggcagcat aatttaggag tttagtgaac ttgcaacatt    840

tactattttc ccttcttacg taaatatttt tctttttaat tctaaatcaa tctttttcaa    900

ttttttgttt gtattctttt cttgcttaaa tctataacta caaaaaacac atacataaat    960

ctagaaaaat gtctcaattc ttcttcaacc agagaaccca cttggtttct gacgttatcg   1020

acggtgctat catcgcttca ccatggaaca atttggctag attggaatct gacccagcta   1080

tcagaatcgt tgttagaaga gacttgaaca agaacaacgt tgctgttatc tctggtggtg   1140

gttctggtca cgaaccagct cacgttggtt tcatcggtaa gggtatgttg accgctgctg   1200

tttgtggtga cgttttcgct tctccatctg ttgacgctgt tttgactgct atccaagctg   1260

ttaccggtga agctggttgt ttgttgatcg ttaagaacta caccggtgac agattgaact   1320

tcggtttggc tgctgaaaag gctagaagat tgggttacaa cgttgaaatg ttgatcgttg   1380

gtgacgacat ctctttgcca gacaacaagc acccaagagg tatcgctggt accatcttgg   1440

ttcacaagat cgctggttac ttcgctgaaa gaggttacaa cttagctacc gttttgagag   1500

aagctcaata cgctgcttct aacaccttct ctttgggtgt tgctttgtct tcttgtcact   1560

tgccacaaga aaccgacgct gctccaagac accacccagg tcacgctgaa ttgggtatgg   1620

gtatccacgg tgaaccaggt gcttctgtta tcgacaccca aaactctgct caagttgtta   1680

acttgatggt tgacaagttg ttggctgctt tgccagaaac cggtagattg gctgttatga   1740

tcaacaactt gggtggtgtt tctgttgctg aaatggctat catcaccaga gaattggctt   1800

cttctccatt gcactcaaga atcgactggt tgatcggtcc agcttctttg gtaaccgctt   1860

tggacatgaa gggtttctct ttgaccgcta tcgttttgga agaatctatc gaaaaggctt   1920

tgttgaccga agttgaaacc tctaactggc caaccccagt tccaccaaga gaaatcacct   1980

gtgttgtttc ttctcacgct tctgctagag ttgaattcca accatctgct aacgctttgg   2040

ttgctggtat cgttgaattg gttaccgcta ccttgtctga cttggaaacc cacttgaacg   2100

ctttggacgc taaggttggt gacggtgaca ccggttctac cttcgctgct gctgctagag   2160

aaatcgcttc tttgttgcac agacaacaat tgccattgaa caacttggct accttgttcg   2220

ctttgatcgg tgaaagattg accgttgtta tgggtggttc ttctggtgtt ttgatgtcta   2280

tcttcttcac cgctgctggt caaaagttgg aacaaggtgc taacgttgtt gaagctttga   2340

acaccggttt ggctcaaatg aagttctacg gtggtgctga cgaaggtgac agaaccatga   2400

tcgacgcttt gcaaccagct ttgacctctt tgttggctca accaaagaac ttgcaagctg   2460

ctttcgacgc tgctcaagct ggtgctgaaa gaacctgttt gtcttctaag gctaacgctg   2520

gtagagcttc ttacttgtct tctgaatctt tgttgggtaa catggaccca ggtgctcaaa   2580

gattggctat ggttttcaag gctttggctg aatctgaatt gggttaataa ggtcgagaca   2640

aatcgctctt aaatatatac ctaaagaaca ttaaagctat attataagca aagatacgta   2700

aattttgctt atattattat acacatatca tatttctata tttttaagat ttggttatat   2760

aatgtacgta atgcaaagga aataaatttt atacattatt gaacagcgtc caagtaacta   2820

cattatgtgc actaatagtt tagcgtcgtg aagactttat tgtgtcgcga aaagtaaaaa   2880

ttttaaaaat tagagcacct tgaacttgcg aaaaaggttc tcatcaactg tttaaaacgt   2940

acgaagctta a                                                        2951


<210>  55
<211>  14200
<212>  DNA
<213>  Artificial

<220>
<223>  pRN957

<400>  55
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataagacgtc     60

aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca    120

ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa    180

aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt    240

ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca    300

gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag    360

ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc    420

ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca    480

gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt    540

aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct    600

gacaacgatc ggaggaccga aggagctaac cgcttttttt cacaacatgg gggatcatgt    660

aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga    720

caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact    780

tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc    840

acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga    900

gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt    960

agttatctac acgacgggca gtcaggcaac tatggatgaa cgaaatagac agatcgctga   1020

gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact   1080

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga   1140

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt   1200

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca   1260

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct   1320

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta   1380

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct   1440

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc   1500

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca   1560

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agcattgaga   1620

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg   1680

aacaggagag cgcacgaggg agcttccagg ggggaacgcc tggtatcttt atagtcctgt   1740

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggccgag   1800

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt   1860

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt   1920

tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga   1980

ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta   2040

atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa   2100

tgtgagttac ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcctat   2160

gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta   2220

cgccaagctc ggaattaacc ctcactaaag ggaacaaaag ctgggtaccg ggccccccct   2280

cgaggtcgag cttaagacgc gtttcttctt cagattccct catggagaaa gtgcggcaga   2340

tgtatatgac agagtcgcca gtttccaaga gactttattc aggcacttcc atgataggca   2400

agagagaaga cccagagatg ttgttgtcct agttacacat ggtatttatt ccagagtatt   2460

cctgatgaaa tggtttagat ggacatacga agagtttgaa tcgtttacca atgttcctaa   2520

cgggagcgta atggtgatgg aactggacga atccatcaat agatacgtcc tgaggaccgt   2580

gctacccaaa tggactgatt gtgagggaga cctaactaca tagtgtttaa agattacgga   2640

tatttaactt acttagaata atgccatttt tttgagttat aataatccta cgttagtgtg   2700

agcgggattt aaactgtgag gaccttaata cattcagaca cttctgcggt atcaccctac   2760

ttattccctt cgagattata tctaggaacc catcaggttg gtggaagatt acccgttcta   2820

agacttttca gcttcctcta ttgatgttac acctggacac cccttttctg gcatccagtt   2880

tttaatcttc agtggcatgt gagattctcc gaaattaatt aaagcaatca cacaattctc   2940

tcggatacca cctcggttga aactgacagg tggtttgtta cgcatgctaa tgcaaaggag   3000

cctatatacc tttggctcgg ctgctgtaac agggaatata aagggcagca taatttagga   3060

gtttagtgaa cttgcaacat ttactatttt cccttcttac gtaaatattt ttctttttaa   3120

ttctaaatca atctttttca attttttgtt tgtattcttt tcttgcttaa atctataact   3180

acaaaaaaca catacataaa tctagaaaaa tgtctcaatt cttcttcaac cagagaaccc   3240

acttggtttc tgacgttatc gacggtgcta tcatcgcttc accatggaac aatttggcta   3300

gattggaatc tgacccagct atcagaatcg ttgttagaag agacttgaac aagaacaacg   3360

ttgctgttat ctctggtggt ggttctggtc acgaaccagc tcacgttggt ttcatcggta   3420

agggtatgtt gaccgctgct gtttgtggtg acgttttcgc ttctccatct gttgacgctg   3480

ttttgactgc tatccaagct gttaccggtg aagctggttg tttgttgatc gttaagaact   3540

acaccggtga cagattgaac ttcggtttgg ctgctgaaaa ggctagaaga ttgggttaca   3600

acgttgaaat gttgatcgtt ggtgacgaca tctctttgcc agacaacaag cacccaagag   3660

gtatcgctgg taccatcttg gttcacaaga tcgctggtta cttcgctgaa agaggttaca   3720

acttagctac cgttttgaga gaagctcaat acgctgcttc taacaccttc tctttgggtg   3780

ttgctttgtc ttcttgtcac ttgccacaag aaaccgacgc tgctccaaga caccacccag   3840

gtcacgctga attgggtatg ggtatccacg gtgaaccagg tgcttctgtt atcgacaccc   3900

aaaactctgc tcaagttgtt aacttgatgg ttgacaagtt gttggctgct ttgccagaaa   3960

ccggtagatt ggctgttatg atcaacaact tgggtggtgt ttctgttgct gaaatggcta   4020

tcatcaccag agaattggct tcttctccat tgcactcaag aatcgactgg ttgatcggtc   4080

cagcttcttt ggtaaccgct ttggacatga agggtttctc tttgaccgct atcgttttgg   4140

aagaatctat cgaaaaggct ttgttgaccg aagttgaaac ctctaactgg ccaaccccag   4200

ttccaccaag agaaatcacc tgtgttgttt cttctcacgc ttctgctaga gttgaattcc   4260

aaccatctgc taacgctttg gttgctggta tcgttgaatt ggttaccgct accttgtctg   4320

acttggaaac ccacttgaac gctttggacg ctaaggttgg tgacggtgac accggttcta   4380

ccttcgctgc tgctgctaga gaaatcgctt ctttgttgca cagacaacaa ttgccattga   4440

acaacttggc taccttgttc gctttgatcg gtgaaagatt gaccgttgtt atgggtggtt   4500

cttctggtgt tttgatgtct atcttcttca ccgctgctgg tcaaaagttg gaacaaggtg   4560

ctaacgttgt tgaagctttg aacaccggtt tggctcaaat gaagttctac ggtggtgctg   4620

acgaaggtga cagaaccatg atcgacgctt tgcaaccagc tttgacctct ttgttggctc   4680

aaccaaagaa cttgcaagct gctttcgacg ctgctcaagc tggtgctgaa agaacctgtt   4740

tgtcttctaa ggctaacgct ggtagagctt cttacttgtc ttctgaatct ttgttgggta   4800

acatggaccc aggtgctcaa agattggcta tggttttcaa ggctttggct gaatctgaat   4860

tgggttaata aggtcgagac aaatcgctct taaatatata cctaaagaac attaaagcta   4920

tattataagc aaagatacgt aaattttgct tatattatta tacacatatc atatttctat   4980

atttttaaga tttggttata taatgtacgt aatgcaaagg aaataaattt tatacattat   5040

tgaacagcgt ccaagtaact acattatgtg cactaatagt ttagcgtcgt gaagacttta   5100

ttgtgtcgcg aaaagtaaaa attttaaaaa ttagagcacc ttgaacttgc gaaaaaggtt   5160

ctcatcaact gtttaaaacg tacgcctagg aagccttcga gcgtcccaaa accttctcaa   5220

gcaaggtttt cagtataatg ttacatgcgt acacgcgttt gtacagaaaa aaaagaaaaa   5280

tttgaaatat aaataacgtt cttaatacta acataactat taaaaaaaat aaatagggac   5340

ctagacttca ggttgtctaa ctccttcctt ttcggttaga gcggatgtgg gaggagggcg   5400

tgaatgtaag cgtgacataa ctaattacat gatatcgaca aaggaaaagg ggcgcgcctt   5460

attcccattc ttgtaggaat ctttgaccgt attggtcagc aaccaacaaa gcagcgtaaa   5520

cttggtctgg ggtagcacca cctggcatgt tgtggatggt ttcaccttca gcacaagcag   5580

cttcagcaac gattctcatc ttagctggaa cgtcttcctt gatgtccaat tgagccaagg   5640

tgattggcaa accaacagcg tgagacaaag cagcaacggt ttcgatttct tcaactggag   5700

cgttttccaa aaccaattgg gtcaaggtac cgaaagcaac cttttcaccg tggtagtagt   5760

ggtgagcgtc tgggatagcg gtcaaaccgt tgtgaacagc gtgagcagca gccaaaccac   5820

cagattcgaa accaacacca gacaagtagg tgttagcttc gataactctt tccaaagctg   5880

gggtaacaac gtgttgttca gcagccaaca tagccttttc accttcttcc aacaaggtgt   5940

tgtaacacaa ttcagccaaa gccaaagcag cttgggtaca cttaccacca gccatggtgg   6000

tagcaccaga tctagaacaa gctctagctt cgaaccaggt agccaaagcg tcaccgatac   6060

cagctgccaa caatctagct ggagcaccag caacgatctt ggtgtcaacg ataaccatgt   6120

ttgggttgtt tggcaacaac aagtatctgt cgaattcacc ttcgtcggtg tagataacag   6180

acaaagcaga acatggagcg tcggtagaag cgatggttgg agcgatagca actggaacac   6240

ccatgaagtg agccaaagcc ttagcggtgt ccaaggtctt accaccaccg atacccaaga   6300

tagcaccaca ttgagcggtt tcagcgatac ctctcaatct gtcgatttcg ttttgagaac   6360

attcaccacc gaatggagcg atttcaacaa ccaaaccagc gtccttgaaa gacttttcaa   6420

cggtagattg agcgaaaccc aaaacgaact tgtcaccaac aaccaaccat ctttcagcca   6480

atggcttcaa gtattcaccc aatctgttga taacgtcagc accttggatg tacttacctg   6540

gagattggat gattctgtcc attttctgca gttaattcag taaattttcg atcttgggaa   6600

gaaaaaagca gtaagcgtga aaaatctaaa agctgatgta gtagaagatc ctattcttta   6660

acaaagattg accttttctt tttcttcttg gtttgagtag aaaggggaag gaagaataca   6720

agagagagga aaaaaaggaa gataaaaaga gagcgtgata taaatgaata tatattaaac   6780

aagagagatt gggaaggaaa ggatcaaaca aacccaaaaa tatttcaaaa aggagagaga   6840

gaggcgagtt tggtttcaaa acggtttatt tatttatgca agaggacgtg gaagaaaaag   6900

aagaaggaag aaaaaaattt gaaagaaaaa aacgcgtggc gggtaaagaa gaaaatggaa   6960

aatagaggcc gggtgacaga gaaatattga gggttaattg gaaaatatgt tagggtgagg   7020

catatgtttt taagggtttt gaggatccga taaggaagaa tgtaggttaa atgttgtgca   7080

ttaattgctg tggcagctta cccgcttccc cacacattta ctagtctcga gctcttcaac   7140

tcaagacgca cagatattat aacatctgca taataggcat ttgcaagaat tactcgtgag   7200

taaggaaaga gtgaggaact atcgcatacc tgcatttaaa gatgccgatt tgggcgcgaa   7260

tcctttattt tggcttcacc ctcatactat tatcagggcc agaaaaagga agtgtttccc   7320

tccttcttga attgatgtta ccctcataaa gcacgtggcc tcttatcgag aaagaaatta   7380

ccgtcgctcg tgatttgttt gcaaaaagaa caaaactgaa aaaacccaga cacgctcgac   7440

ttcctgtctt cctattgatt gcagcttcca atttcgtcac acaacaaggt cctagcgacg   7500

gctcacaggt tttgtaacaa gcaatcgaag gttctggaat ggcgggaaag ggtttagtac   7560

cacatgctat gatgcccact gtgatctcca gagcaaagtt cgttcgatcg tactgttact   7620

ctctctcttt caaacagaat tgtccgaatc gtgtgacaac aacagcctgt tctcacacac   7680

tcttttcttc taaccaaggg ggtggtttag tttagtagaa cctcgtgaaa cttacattta   7740

catatatata aacttgcata aattggtcaa tgcaagaaat acatatttgg tcttttctaa   7800

ttcgtagttt ttcaagttct tagatgcttt ctttttctct tttttacaga tcatcaagga   7860

agtaattatc tactttttac aacaaatata tctagaaaat ggctgttacc aacgttgctg   7920

aattgaacgc tttggttgaa agggttaaga aggctcaaag agaatacgct tctttcaccc   7980

aagaacaagt tgacaagatc ttcagagctg ctgctttggc tgctgctgac gctagaatcc   8040

cattggctaa gatggctgtt gctgaatctg gtatgggtat cgttgaagac aaggttatca   8100

agaaccactt cgcttctgaa tacatctaca acgcttacaa ggacgaaaag acctgtggtg   8160

ttttgtcaga agacgacacc ttcggtacca tcaccatcgc tgaaccaatc ggtatcatct   8220

gtggtatcgt tccaaccacc aacccaacct ctaccgctat cttcaagtct ttgatctctt   8280

tgaagaccag aaacgctatc atcttctctc cacacccaag agctaaagac gctaccaaca   8340

aggctgctga catcgttttg caagctgcta tcgctgctgg tgctccaaag gacttgatcg   8400

gttggatcga ccaaccatct gttgaattgt ctaacgcttt gatgcaccac ccagacatca   8460

acttgatctt ggctaccggt ggtccaggta tggttaaggc tgcttactct tctggtaagc   8520

cagctatcgg tgttggtgct ggtaacaccc cagttgttat cgacgaaacc gctgacatca   8580

agagagctgt tgcttctgtt ttgatgtcta agaccttcga caacggtgtt atctgtgctt   8640

ctgaacaatc tgttgttgtt gttgactctg tttacgacgc tgttagagaa agattcgcta   8700

cccacggtgg ttacttgttg caaggtaagg aattgaaggc tgttcaagac gttatcttga   8760

agaacggtgc tttgaacgct gctatcgttg gtcaaccagc ttacaagatc gctgaattag   8820

ctggtttctc tgttccagaa aacaccaaga tcttgatcgg tgaagttacc gttgttgacg   8880

aatctgaacc attcgctcac gaaaagttgt ctccaacctt ggctatgtac agagctaagg   8940

acttcgaaga cgctgttgaa aaagctgaaa agttggttgc tatgggtggt attggtcaca   9000

cctcttgttt gtacaccgac caagacaacc aaccagctag agtttcttac ttcggtcaaa   9060

agatgaagac cgctagaatc ttgatcaaca ccccagcttc tcaaggtggt atcggtgact   9120

tgtacaactt caagttggct ccatctttga ccttgggttg tggttcttgg ggtggtaact   9180

ctatctctga aaacgttggt ccaaagcact tgatcaacaa gaagaccgtt gctaagagag   9240

ctgaaaacat gttgtggcac aagttgccaa aatctatcta cttcagaaga ggttctttgc   9300

caatcgcttt ggacgaagtt atcaccgacg gtcacaagag agctttgatc gttaccgaca   9360

gattcttgtt caacaacggt tacgctgacc aaatcacctc tgttttgaag gctgctggtg   9420

ttgaaaccga agttttcttc gaagttgaag ctgacccaac cttgtctatc gttagaaagg   9480

gtgctgaatt ggctaactct ttcaagccag acgttatcat cgctttgggt ggtggttctc   9540

caatggacgc tgctaagatc atgtgggtta tgtacgaaca cccagaaacc cacttcgaag   9600

aattggcttt gagattcatg gacatcagaa agagaatcta caagttccca aagatgggtg   9660

ttaaggctaa gatgatcgct gttaccacca cctctggtac cggttctgaa gttaccccat   9720

tcgctgttgt taccgacgac gctaccggtc aaaagtaccc attggctgac tacgctttga   9780

ccccagacat ggctatcgtt gacgctaact tggttatgga catgccaaag tctttgtgtg   9840

ctttcggtgg tttggacgct gttacccacg ctatggaagc ttacgtttct gttttggctt   9900

ctgaattctc tgacggtcaa gctttgcaag ctttgaagtt gttgaaggaa tacttgccag   9960

cttcttacca cgaaggttct aagaacccag ttgctagaga aagagttcac tctgctgcta  10020

ccatcgctgg tatcgctttc gctaacgctt tcttgggtgt ttgtcactct atggctcaca  10080

agttgggttc tcaattccac atcccacacg gtttggctaa cgctttgttg atctgtaacg  10140

ttatcagata caacgctaac gacaacccaa ccaagcaaac cgctttctct caatacgaca  10200

gaccacaagc tagaagaaga tacgctgaaa tcgctgacca cttgggtttg tctgctccag  10260

gtgacagaac cgctgcaaag atcgaaaagt tgttggcttg gttggaaacc ttgaaggctg  10320

aattgggtat cccaaagtct atcagagaag ctggtgttca agaagctgac ttcttggcta  10380

acgttgacaa gttgtctgaa gacgctttcg acgaccaatg taccggtgct aacccaagat  10440

acccattgat ctctgaattg aagcaaatct tgttggacac ctactacggt agagactacg  10500

ttgaaggtga aaccgctgct aagaaggaag ctgctccagc taaggctgaa aagaaggcta  10560

agaagtctgc ttagcttaag cgcgcgaatt tcttatgatt tatgattttt attattaaat  10620

aagttataaa aaaaataagt gtatacaaat tttaaagtga ctcttaggtt ttaaaacgaa  10680

aattcttatt cttgagtaac tctttcctgt aggtcaggtt gctttctcag gtatagcatg  10740

aggtcgctct tattgaccac acctctaccg gcatgccgag caaatgcctg caaatcgctc  10800

cccatttcac ccaattgtag atatgctaac tccagcaatg agttgatgaa tctcggtgtg  10860

tattttatgt cctcagagga caacacctgt tgtaatcgtt cttccacacg tacgaagctt  10920

aaaagggcga attctgcaga tatccatcac actggcggcc gcatgctagc tccggattat  10980

cgatgataag ctgtcaaaga tgagaattaa ttccacggac tatagactat actagatact  11040

ccgtctactg tacgatacac ttccgctcag gtccttgtcc tttaacgagg ccttaccact  11100

cttttgttac tctattgatc cagctcagca aaggcagtgt gatctaagat tctatcttcg  11160

cgatgtagta aaactagcta gaccgagaaa gagactagaa atgcaaaagg cacttctaca  11220

atggctgcca tcattattat ccgatgtgac gctgcagctt ctcaatgata ttcgaatacg  11280

ctttgaggag atacagccta atatccgaca aactgtttta cagatttacg atcgtacttg  11340

ttacccatca ttgaattttg aacatccgaa cctgggagtt ttccctgaaa cagatagtat  11400

atttgaacct gtataataat atatagtcta gcgctttacg gaagacaatg tatgtatttc  11460

ggttcctgga gaaactattg catctattgc ataggtaatc ttgcacgtcg catccccggt  11520

tcattttctg cgtttccatc ttgcacttca atagcatatc tttgttaacg aagcatctgt  11580

gcttcatttt gtagaacaaa aatgcaacgc gagagcgcta atttttcaaa caaagaatct  11640

gagctgcatt tttacagaac agaaatgcaa cgcgaaagcg ctattttacc aacgaagaat  11700

ctgtgcttca tttttgtaaa acaaaaatgc aacgcgacga gagcgctaat ttttcaaaca  11760

aagaatctga gctgcatttt tacagaacag aaatgcaacg cgagagcgct attttaccaa  11820

caaagaatct atacttcttt tttgttctac aaaaatgcat cccgagagcg ctatttttct  11880

aacaaagcat cttagattac tttttttctc ctttgtgcgc tctataatgc agtctcttga  11940

taactttttg cactgtaggt ccgttaaggt tagaagaagg ctactttggt gtctattttc  12000

tcttccataa aaaaagcctg actccacttc ccgcgtttac tgattactag cgaagctgcg  12060

ggtgcatttt ttcaagataa aggcatcccc gattatattc tataccgatg tggattgcgc  12120

atactttgtg aacagaaagt gatagcgttg atgattcttc attggtcaga aaattatgaa  12180

cggtttcttc tattttgtct ctatatacta cgtataggaa atgtttacat tttcgtattg  12240

ttttcgattc actctatgaa tagttcttac tacaattttt ttgtctaaag agtaatacta  12300

gagataaaca taaaaaatgt agaggtcgag tttagatgca agttcaagga gcgaaaggtg  12360

gatgggtagg ttatataggg atatagcaca gagatatata gcaaagagat acttttgagc  12420

aatgtttgtg gaagcggtat tcgcaatgcc ggctttcccc gtcaagctct aaatcggggg  12480

ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag  12540

ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg  12600

gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc  12660

tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat  12720

gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt tacaatttcc  12780

tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata tgatccgtcg  12840

agttcaagag aaaaaaaaag aaaaagcaaa aagaaaaaag gaaagcgcgc ctcgttcaga  12900

atgacacgta tagaatgatg cattaccttg tcatcttcag tatcatactg ttcgtataca  12960

tacttactga cattcatagg tatacatata tacacatgta tatatatcgt atgctgcagc  13020

tttaaataat cggtgtcact acataagaac acctttggtg gagggaacat cgttggtacc  13080

attgggcgag gtggcttctc ttatggcaac cgcaagagcc ttgaacgcac tctcactacg  13140

gtgatgatca ttcttgcctc gcagacaatc aacgtggagg gtaattctgc tagcctctgc  13200

aaagctttca agaaaatgcg ggatcatctc gcaagagaga tctcctactt tctccctttg  13260

caaaccaagt tcgacaactg cgtacggcct gttcgaaaga tctaccaccg ctctggaaag  13320

tgcctcatcc aaaggcgcaa atcctgatcc aaaccttttt actccacgcg ccagtagggc  13380

ctctttaaaa gcttgaccga gagcaatccc gcagtcttca gtggtgtgat ggtcgtctat  13440

gtgtaagtca ccaatgcact caacgattag cgaccagccg gaatgcttgg ccagagcatg  13500

tatcatatgg tccagaaacc ctatacctgt gtggacgtta atcacttgcg attgtgtggc  13560

ctgttctgct actgcttctg cctctttttc tgggaagatc gagtgctcta tcgctagggg  13620

accacccttt aaagagatcg caatctgaat cttggtttca tttgtaatac gctttactag  13680

ggctttctgc tctgtcatct ttgccttcgt ttatcttgcc tgctcatttt ttagtatatt  13740

cttcgaagaa atcacattac tttatataat gtataattca ttatgtgata atgccaatcg  13800

ctaagaaaaa aaaagagtca tccgctaggt ggaaaaaaaa aaatgaaaat cattaccgag  13860

gcataaaaaa atatagagtg tactagagga ggccaagagt aatagaaaaa gaaaattgcg  13920

ggaaaggact gtgttatgac ttccctgact aatgccgtgt tcaaacgata cctggcagtg  13980

actcctagcg ctcaccaagc tcttaaaacg gaattatggt gcactctcag tacaatctgc  14040

tctgatgccg catagttaag ccagccccga cacccgccaa cacccgctga cgcgccctga  14100

cgggcttgtc tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc  14160

atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga                        14200


<210>  56
<211>  11289
<212>  DNA
<213>  Artificial

<220>
<223>  pRN958

<400>  56
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataagacgtc     60

aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca    120

ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa    180

aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt    240

ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca    300

gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag    360

ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc    420

ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca    480

gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt    540

aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct    600

gacaacgatc ggaggaccga aggagctaac cgcttttttt cacaacatgg gggatcatgt    660

aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga    720

caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact    780

tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc    840

acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga    900

gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt    960

agttatctac acgacgggca gtcaggcaac tatggatgaa cgaaatagac agatcgctga   1020

gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact   1080

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga   1140

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt   1200

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca   1260

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct   1320

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta   1380

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct   1440

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc   1500

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca   1560

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agcattgaga   1620

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg   1680

aacaggagag cgcacgaggg agcttccagg ggggaacgcc tggtatcttt atagtcctgt   1740

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggccgag   1800

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt   1860

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt   1920

tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga   1980

ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta   2040

atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa   2100

tgtgagttac ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcctat   2160

gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta   2220

cgccaagctc ggaattaacc ctcactaaag ggaacaaaag ctgggtaccg ggccctagga   2280

agccttcgag cgtcccaaaa ccttctcaag caaggttttc agtataatgt tacatgcgta   2340

cacgcgtttg tacagaaaaa aaagaaaaat ttgaaatata aataacgttc ttaatactaa   2400

cataactatt aaaaaaaata aatagggacc tagacttcag gttgtctaac tccttccttt   2460

tcggttagag cggatgtggg aggagggcgt gaatgtaagc gtgacataac taattacatg   2520

atatcgacaa aggaaaaggg gcgcgcctta ttcccattct tgtaggaatc tttgaccgta   2580

ttggtcagca accaacaaag cagcgtaaac ttggtctggg gtagcaccac ctggcatgtt   2640

gtggatggtt tcaccttcag cacaagcagc ttcagcaacg attctcatct tagctggaac   2700

gtcttccttg atgtccaatt gagccaaggt gattggcaaa ccaacagcgt gagacaaagc   2760

agcaacggtt tcgatttctt caactggagc gttttccaaa accaattggg tcaaggtacc   2820

gaaagcaacc ttttcaccgt ggtagtagtg gtgagcgtct gggatagcgg tcaaaccgtt   2880

gtgaacagcg tgagcagcag ccaaaccacc agattcgaaa ccaacaccag acaagtaggt   2940

gttagcttcg ataactcttt ccaaagctgg ggtaacaacg tgttgttcag cagccaacat   3000

agccttttca ccttcttcca acaaggtgtt gtaacacaat tcagccaaag ccaaagcagc   3060

ttgggtacac ttaccaccag ccatggtggt agcaccagat ctagaacaag ctctagcttc   3120

gaaccaggta gccaaagcgt caccgatacc agctgccaac aatctagctg gagcaccagc   3180

aacgatcttg gtgtcaacga taaccatgtt tgggttgttt ggcaacaaca agtatctgtc   3240

gaattcacct tcgtcggtgt agataacaga caaagcagaa catggagcgt cggtagaagc   3300

gatggttgga gcgatagcaa ctggaacacc catgaagtga gccaaagcct tagcggtgtc   3360

caaggtctta ccaccaccga tacccaagat agcaccacat tgagcggttt cagcgatacc   3420

tctcaatctg tcgatttcgt tttgagaaca ttcaccaccg aatggagcga tttcaacaac   3480

caaaccagcg tccttgaaag acttttcaac ggtagattga gcgaaaccca aaacgaactt   3540

gtcaccaaca accaaccatc tttcagccaa tggcttcaag tattcaccca atctgttgat   3600

aacgtcagca ccttggatgt acttacctgg agattggatg attctgtcca ttttctgcag   3660

ttaattcagt aaattttcga tcttgggaag aaaaaagcag taagcgtgaa aaatctaaaa   3720

gctgatgtag tagaagatcc tattctttaa caaagattga ccttttcttt ttcttcttgg   3780

tttgagtaga aaggggaagg aagaatacaa gagagaggaa aaaaaggaag ataaaaagag   3840

agcgtgatat aaatgaatat atattaaaca agagagattg ggaaggaaag gatcaaacaa   3900

acccaaaaat atttcaaaaa ggagagagag aggcgagttt ggtttcaaaa cggtttattt   3960

atttatgcaa gaggacgtgg aagaaaaaga agaaggaaga aaaaaatttg aaagaaaaaa   4020

acgcgtggcg ggtaaagaag aaaatggaaa atagaggccg ggtgacagag aaatattgag   4080

ggttaattgg aaaatatgtt agggtgaggc atatgttttt aagggttttg aggatccgat   4140

aaggaagaat gtaggttaaa tgttgtgcat taattgctgt ggcagcttac ccgcttcccc   4200

acacatttac tagtctcgag ctcttcaact caagacgcac agatattata acatctgcat   4260

aataggcatt tgcaagaatt actcgtgagt aaggaaagag tgaggaacta tcgcatacct   4320

gcatttaaag atgccgattt gggcgcgaat cctttatttt ggcttcaccc tcatactatt   4380

atcagggcca gaaaaaggaa gtgtttccct ccttcttgaa ttgatgttac cctcataaag   4440

cacgtggcct cttatcgaga aagaaattac cgtcgctcgt gatttgtttg caaaaagaac   4500

aaaactgaaa aaacccagac acgctcgact tcctgtcttc ctattgattg cagcttccaa   4560

tttcgtcaca caacaaggtc ctagcgacgg ctcacaggtt ttgtaacaag caatcgaagg   4620

ttctggaatg gcgggaaagg gtttagtacc acatgctatg atgcccactg tgatctccag   4680

agcaaagttc gttcgatcgt actgttactc tctctctttc aaacagaatt gtccgaatcg   4740

tgtgacaaca acagcctgtt ctcacacact cttttcttct aaccaagggg gtggtttagt   4800

ttagtagaac ctcgtgaaac ttacatttac atatatataa acttgcataa attggtcaat   4860

gcaagaaata catatttggt cttttctaat tcgtagtttt tcaagttctt agatgctttc   4920

tttttctctt ttttacagat catcaaggaa gtaattatct actttttaca acaaatatat   4980

ctagaaaatg gctgttacca acgttgctga attgaacgct ttggttgaaa gggttaagaa   5040

ggctcaaaga gaatacgctt ctttcaccca agaacaagtt gacaagatct tcagagctgc   5100

tgctttggct gctgctgacg ctagaatccc attggctaag atggctgttg ctgaatctgg   5160

tatgggtatc gttgaagaca aggttatcaa gaaccacttc gcttctgaat acatctacaa   5220

cgcttacaag gacgaaaaga cctgtggtgt tttgtcagaa gacgacacct tcggtaccat   5280

caccatcgct gaaccaatcg gtatcatctg tggtatcgtt ccaaccacca acccaacctc   5340

taccgctatc ttcaagtctt tgatctcttt gaagaccaga aacgctatca tcttctctcc   5400

acacccaaga gctaaagacg ctaccaacaa ggctgctgac atcgttttgc aagctgctat   5460

cgctgctggt gctccaaagg acttgatcgg ttggatcgac caaccatctg ttgaattgtc   5520

taacgctttg atgcaccacc cagacatcaa cttgatcttg gctaccggtg gtccaggtat   5580

ggttaaggct gcttactctt ctggtaagcc agctatcggt gttggtgctg gtaacacccc   5640

agttgttatc gacgaaaccg ctgacatcaa gagagctgtt gcttctgttt tgatgtctaa   5700

gaccttcgac aacggtgtta tctgtgcttc tgaacaatct gttgttgttg ttgactctgt   5760

ttacgacgct gttagagaaa gattcgctac ccacggtggt tacttgttgc aaggtaagga   5820

attgaaggct gttcaagacg ttatcttgaa gaacggtgct ttgaacgctg ctatcgttgg   5880

tcaaccagct tacaagatcg ctgaattagc tggtttctct gttccagaaa acaccaagat   5940

cttgatcggt gaagttaccg ttgttgacga atctgaacca ttcgctcacg aaaagttgtc   6000

tccaaccttg gctatgtaca gagctaagga cttcgaagac gctgttgaaa aagctgaaaa   6060

gttggttgct atgggtggta ttggtcacac ctcttgtttg tacaccgacc aagacaacca   6120

accagctaga gtttcttact tcggtcaaaa gatgaagacc gctagaatct tgatcaacac   6180

cccagcttct caaggtggta tcggtgactt gtacaacttc aagttggctc catctttgac   6240

cttgggttgt ggttcttggg gtggtaactc tatctctgaa aacgttggtc caaagcactt   6300

gatcaacaag aagaccgttg ctaagagagc tgaaaacatg ttgtggcaca agttgccaaa   6360

atctatctac ttcagaagag gttctttgcc aatcgctttg gacgaagtta tcaccgacgg   6420

tcacaagaga gctttgatcg ttaccgacag attcttgttc aacaacggtt acgctgacca   6480

aatcacctct gttttgaagg ctgctggtgt tgaaaccgaa gttttcttcg aagttgaagc   6540

tgacccaacc ttgtctatcg ttagaaaggg tgctgaattg gctaactctt tcaagccaga   6600

cgttatcatc gctttgggtg gtggttctcc aatggacgct gctaagatca tgtgggttat   6660

gtacgaacac ccagaaaccc acttcgaaga attggctttg agattcatgg acatcagaaa   6720

gagaatctac aagttcccaa agatgggtgt taaggctaag atgatcgctg ttaccaccac   6780

ctctggtacc ggttctgaag ttaccccatt cgctgttgtt accgacgacg ctaccggtca   6840

aaagtaccca ttggctgact acgctttgac cccagacatg gctatcgttg acgctaactt   6900

ggttatggac atgccaaagt ctttgtgtgc tttcggtggt ttggacgctg ttacccacgc   6960

tatggaagct tacgtttctg ttttggcttc tgaattctct gacggtcaag ctttgcaagc   7020

tttgaagttg ttgaaggaat acttgccagc ttcttaccac gaaggttcta agaacccagt   7080

tgctagagaa agagttcact ctgctgctac catcgctggt atcgctttcg ctaacgcttt   7140

cttgggtgtt tgtcactcta tggctcacaa gttgggttct caattccaca tcccacacgg   7200

tttggctaac gctttgttga tctgtaacgt tatcagatac aacgctaacg acaacccaac   7260

caagcaaacc gctttctctc aatacgacag accacaagct agaagaagat acgctgaaat   7320

cgctgaccac ttgggtttgt ctgctccagg tgacagaacc gctgcaaaga tcgaaaagtt   7380

gttggcttgg ttggaaacct tgaaggctga attgggtatc ccaaagtcta tcagagaagc   7440

tggtgttcaa gaagctgact tcttggctaa cgttgacaag ttgtctgaag acgctttcga   7500

cgaccaatgt accggtgcta acccaagata cccattgatc tctgaattga agcaaatctt   7560

gttggacacc tactacggta gagactacgt tgaaggtgaa accgctgcta agaaggaagc   7620

tgctccagct aaggctgaaa agaaggctaa gaagtctgct tagcttaagc gcgcgaattt   7680

cttatgattt atgattttta ttattaaata agttataaaa aaaataagtg tatacaaatt   7740

ttaaagtgac tcttaggttt taaaacgaaa attcttattc ttgagtaact ctttcctgta   7800

ggtcaggttg ctttctcagg tatagcatga ggtcgctctt attgaccaca cctctaccgg   7860

catgccgagc aaatgcctgc aaatcgctcc ccatttcacc caattgtaga tatgctaact   7920

ccagcaatga gttgatgaat ctcggtgtgt attttatgtc ctcagaggac aacacctgtt   7980

gtaatcgttc ttccacacgt acgaagctta aaagggcgaa ttctgcagat atccatcaca   8040

ctggcggccg catgctagct ccggattatc gatgataagc tgtcaaagat gagaattaat   8100

tccacggact atagactata ctagatactc cgtctactgt acgatacact tccgctcagg   8160

tccttgtcct ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa   8220

aggcagtgtg atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag   8280

agactagaaa tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg   8340

ctgcagcttc tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa   8400

actgttttac agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac   8460

ctgggagttt tccctgaaac agatagtata tttgaacctg tataataata tatagtctag   8520

cgctttacgg aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca   8580

taggtaatct tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa   8640

tagcatatct ttgttaacga agcatctgtg cttcattttg tagaacaaaa atgcaacgcg   8700

agagcgctaa tttttcaaac aaagaatctg agctgcattt ttacagaaca gaaatgcaac   8760

gcgaaagcgc tattttacca acgaagaatc tgtgcttcat ttttgtaaaa caaaaatgca   8820

acgcgacgag agcgctaatt tttcaaacaa agaatctgag ctgcattttt acagaacaga   8880

aatgcaacgc gagagcgcta ttttaccaac aaagaatcta tacttctttt ttgttctaca   8940

aaaatgcatc ccgagagcgc tatttttcta acaaagcatc ttagattact ttttttctcc   9000

tttgtgcgct ctataatgca gtctcttgat aactttttgc actgtaggtc cgttaaggtt   9060

agaagaaggc tactttggtg tctattttct cttccataaa aaaagcctga ctccacttcc   9120

cgcgtttact gattactagc gaagctgcgg gtgcattttt tcaagataaa ggcatccccg   9180

attatattct ataccgatgt ggattgcgca tactttgtga acagaaagtg atagcgttga   9240

tgattcttca ttggtcagaa aattatgaac ggtttcttct attttgtctc tatatactac   9300

gtataggaaa tgtttacatt ttcgtattgt tttcgattca ctctatgaat agttcttact   9360

acaatttttt tgtctaaaga gtaatactag agataaacat aaaaaatgta gaggtcgagt   9420

ttagatgcaa gttcaaggag cgaaaggtgg atgggtaggt tatataggga tatagcacag   9480

agatatatag caaagagata cttttgagca atgtttgtgg aagcggtatt cgcaatgccg   9540

gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac   9600

ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct   9660

gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt   9720

tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt   9780

tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt   9840

ttaacaaaat attaacgttt acaatttcct gatgcggtat tttctcctta cgcatctgtg   9900

cggtatttca caccgcatat gatccgtcga gttcaagaga aaaaaaaaga aaaagcaaaa   9960

agaaaaaagg aaagcgcgcc tcgttcagaa tgacacgtat agaatgatgc attaccttgt  10020

catcttcagt atcatactgt tcgtatacat acttactgac attcataggt atacatatat  10080

acacatgtat atatatcgta tgctgcagct ttaaataatc ggtgtcacta cataagaaca  10140

cctttggtgg agggaacatc gttggtacca ttgggcgagg tggcttctct tatggcaacc  10200

gcaagagcct tgaacgcact ctcactacgg tgatgatcat tcttgcctcg cagacaatca  10260

acgtggaggg taattctgct agcctctgca aagctttcaa gaaaatgcgg gatcatctcg  10320

caagagagat ctcctacttt ctccctttgc aaaccaagtt cgacaactgc gtacggcctg  10380

ttcgaaagat ctaccaccgc tctggaaagt gcctcatcca aaggcgcaaa tcctgatcca  10440

aaccttttta ctccacgcgc cagtagggcc tctttaaaag cttgaccgag agcaatcccg  10500

cagtcttcag tggtgtgatg gtcgtctatg tgtaagtcac caatgcactc aacgattagc  10560

gaccagccgg aatgcttggc cagagcatgt atcatatggt ccagaaaccc tatacctgtg  10620

tggacgttaa tcacttgcga ttgtgtggcc tgttctgcta ctgcttctgc ctctttttct  10680

gggaagatcg agtgctctat cgctagggga ccacccttta aagagatcgc aatctgaatc  10740

ttggtttcat ttgtaatacg ctttactagg gctttctgct ctgtcatctt tgccttcgtt  10800

tatcttgcct gctcattttt tagtatattc ttcgaagaaa tcacattact ttatataatg  10860

tataattcat tatgtgataa tgccaatcgc taagaaaaaa aaagagtcat ccgctaggtg  10920

gaaaaaaaaa aatgaaaatc attaccgagg cataaaaaaa tatagagtgt actagaggag  10980

gccaagagta atagaaaaag aaaattgcgg gaaaggactg tgttatgact tccctgacta  11040

atgccgtgtt caaacgatac ctggcagtga ctcctagcgc tcaccaagct cttaaaacgg  11100

aattatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc cagccccgac  11160

acccgccaac acccgctgac gcgccctgac gggcttgtct gctcccggca tccgcttaca  11220

gacaagctgt gaccgtctcc gggagctgca tgtgtcagag gttttcaccg tcatcaccga  11280

aacgcgcga                                                          11289


<210>  57
<211>  11102
<212>  DNA
<213>  Artificial

<220>
<223>  pRN607

<400>  57
agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg     60

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga    120

gatacctaca gcgtgagcat tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca    180

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggga    240

acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt    300

tgtgatgctc gtcagggggg ccgagcctat ggaaaaacgc cagcaacgcg gcctttttac    360

ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt    420

ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga    480

ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc    540

tccccgcgcg ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag    600

cgggcagtga gcgcaacgca attaatgtga gttacctcac tcattaggca ccccaggctt    660

tacactttat gcttccggct cctatgttgt gtggaattgt gagcggataa caatttcaca    720

caggaaacag ctatgaccat gattacgcca agctcggaat taaccctcac taaagggaac    780

aaaagctggg tacgttttaa acagttgatg agaacctttt tcgcaagttc aaggtgctct    840

aatttttaaa atttttactt ttcgcgacac aataaagtct tcacgacgct aaactattag    900

tgcacataat gtagttactt ggacgctgtt caataatgta taaaatttat ttcctttgca    960

ttacgtacat tatataacca aatcttaaaa atatagaaat atgatatgtg tataataata   1020

taagcaaaat ttacgtatct ttgcttataa tatagcttta atgttcttta ggtatatatt   1080

taagagcgat ttgtctcgac ttacaaggcg ctttgaaccc ccttcaaaaa ctcacatagg   1140

cctactgcac caggatcttc tacttgagat gaatcgccga catacgaagc tctgccaaat   1200

ttggcctcga atgtagcagt ggatttagca ccttcctctg cagcttttac cgccttattg   1260

aaatccttag atgcagtaaa ttctttaacg aatggttcta aagcatcaat catggtggat   1320

gatcccttcc ttgcctttgt atatttgtat aaagtatcca atgcaattcc gagtgactta   1380

gccacaattt ccttagtgac gggttcatcc tttgatttac aaacctgaat taatccgtgt   1440

gaaaaacccg acaaaagaat agaatataaa ccaccagaag tacctcccat tgagccttca   1500

atgaaatctg aaatttgggc aaccgcctga gataatgagt ccttcgacag cttgtcaagg   1560

ttttcggtga tgcctttaac tcctgccact aaagtgtaac cacaatcacc atcaccaact   1620

tgattgtcta gttccgtaat gtgcggttcg ctcttgataa cttgttcagc accactcttc   1680

atccactcag caaacttgtc aaagtcatag gtaccgacgg cctttgctgt tacttcatta   1740

tgtaacaagt catcgttaac agatggggca gaagtctttt caaaatctgc aattggccag   1800

cccggtgcgt tcgtaaatgc gttcaacaag tctagtactg atttgatctc ctcaaaatca   1860

gattgcaaag cctttgtagc cttagtggcg tttagtaatg tgatactgaa cccattacca   1920

ttgaaggagg tcatcaatgt gccagcaatt gtttgaaccg gggttatgtt gtaattttcc   1980

tttaagaaat ccgtagtttt ggaagtgata gaactaataa caaaattaga aacaccgccg   2040

agattgttaa ctaacaagac aacttcatca tcttcatcaa actttacaaa agctctatcc   2100

ttatcgtttg gatccaatag ttttggtagc atatacttgg agatcaagtc ttcggtagaa   2160

ggaatagggt ctaaaacttt cacaccaggt tcgttatgaa tacccatacc caattccatt   2220

tgtttttcgt ttaattcact ttcgaatttc ctgccaggaa ctttacaatg gtctaaagaa   2280

gatccaatgg tcaccaaatt gtcgttgata attttagcca ctttagctgt accgtctaag   2340

ccatacttac tagaatattc ttctgcgaag gcacctacaa tcttatgaac caaaacggta   2400

cctgccaatg ctcttctacc aaccatacca cccttttctc tgccaactgc aacatcatca   2460

cctatgacag caacgcggca gttaataccc aaggctcttg ctctctcagc ggacagacca   2520

aaatgcaaaa catcacctgt gtagttcttc acaatcaata aaacgccaga cgcattttca   2580

ttgactaaac ggattgcatt taaaatctgt tttgttgaag gggatgcaaa aatttcgcca   2640

accacggcgc cactcaacat acccttacca atgaaaccgg cgtgtgtagg ttcatgtcca   2700

ctaccaccac cagaaattaa tgcgatcttg tcggaatcgg tctttctgaa gagaattttt   2760

tcttcaggga ccagcgtaat ggaggggtta gcaagggcaa accctttgag acttgaattg   2820

actggatctg tgacttcaaa cgatttagcg gacattttct agatttatgt atgtgttttt   2880

tgtagttata gatttaagca agaaaagaat acaaacaaaa aattgaaaaa gattgattta   2940

gaattaaaaa gaaaaatatt tacgtaagaa gggaaaatag taaatgttgc aagttcacta   3000

aactcctaaa ttatgctgcc ctttatattc cctgttacag cagccgagcc aaaggtatat   3060

aggctccttt gcattagcat gcgtaacaaa ccacctgtca gtttcaaccg aggtggtatc   3120

cgagagaatt gtgtgattgc tttaattaat ttcggagaat ctcacatgcc actgaagatt   3180

aaaaactgga tgccagaaaa ggggtgtcca ggtgtaacat caatagagga agctgaaaag   3240

tcttagaacg ggtaatcttc caccaacctg atgggttcct agatataatc tcgaagggaa   3300

taagtagggt gataccgcag aagtgtctga atgtattaag gtcctcacag tttaaatccc   3360

gctcacacta acgtaggatt attataactc aaaaaaatgg cattattcta agtaagttaa   3420

atatccgtaa tctttaaaca ctatgtagtt aggtctccct cacaatcagt ccatttgggt   3480

agcacggtcc tcaggacgta tctattgatg gattcgtcca gttccatcac cattacgctc   3540

ccgttaggaa cattggtaaa cgattcaaac tcttcgtatg tccatctaaa ccatttcatc   3600

aggaatactc tggaataaat accatgtgta actaggacaa caacatctct gggtcttctc   3660

tcttgcctat catggaagtg cctgaataaa gtctcttgga aactggcgac tctgtcatat   3720

acatctgccg cactttctcc atgagggaat ctgaagaaga aaccggttta tcattatcaa   3780

tactgccatt tcaaagaata cgtaaataat taatagtagt gattttccta actttattta   3840

gtcaaaaaat tagcctttta attctgctgt aacccgtaca tgcccaaaat agggggcggg   3900

ttacacagaa tatataacat cgtaggtgtc tgggtgaaca gtttattcct ggcatccact   3960

aaatataatg gagcccgctt tttaagctgg catccagaaa aaaaaagaat cccagcacca   4020

aaatattgtt ttcttcacca accatcagtt cataggtcca ttctcttagc gcaactacag   4080

agaacagggg cacaaacagg caaaaaacgg gcacaacctc aatggagtga tgcaacctgc   4140

ctggagtaaa tgatgacaca aggcaattga cccacgcatg tatctatctc attttcttac   4200

accttctatt accttctgct ctctctgatt tggaaaaagc tgaaaaaaaa ggttgaaacc   4260

agttccctga aattattccc ctacttgact aataagtata taaagacggt aggtattgat   4320

tgtaattctg taaatctatt tcttaaactt cttaaattct acttttatag ttagtctttt   4380

ttttagtttt aaaacaccaa gaacttagtt tcgaataaac acacataaag aattcaaaat   4440

gtcgctgatc agcatcctgt ctcccctaat tacttccgag ggcttagatt caagaatcaa   4500

accttcacca aaaaaggatg cctctactac cactaagcca tcactatgga aaactactga   4560

gttcaaattc tactacattg catttctggt cgtggttccc ttgatgttct atgctgggtt   4620

acaagctagt tcgcccgaaa atccaaacta tgcaagatac gaacgtctcc tatctcaagg   4680

ttggttattt ggcagaaaag tagacaatag tgattctcaa tataggtttt tcagggacaa   4740

ttttgcgcta ttgtcagttt taatgctagt ccacacttct ataaaacgca ttgtacttta   4800

ttcaacaaat atcactaaat tgaggtttga tctgatattt ggtttgatct ttttagtggc   4860

cgctcatggt gtcaattcga taagaatttt agcccatatg ctaattttat atgccatcgc   4920

ccatgtacta aagaacttta gaagaatagc caccatcagc atttggattt atggtatttc   4980

tacgcttttt attaacgaca acttcagagc atatccattt ggtaatattt gctctttttt   5040

aagcccattg gaccattggt atagaggtat cattccaaga tgggatgtct ttttcaattt   5100

tactcttttg agagtcttaa gttacaactt ggacttctta gagaggtggg agaatttaca   5160

aaagaagaaa agtccatcct atgaatcaaa agaagctaaa tcagccattt tgctcaatga   5220

acgtgctaga ttaactgctg cacaccccat acaggactac agcttaatga attatattgc   5280

atatgttact tacacgccac ttttcattgc cggccccatt ataacattca atgattatgt   5340

ttaccaatcg aaacatacct tgccatcaat aaatttcaaa ttcatttttt actatgcggt   5400

gagattcgtt attgctctct tatctatgga gttcatttta cactttctcc acgttgtggc   5460

aatctcaaaa accaaagcgt gggaaaatga cacacctttc cagatttcca tgattggctt   5520

atttaatttg aatattattt ggctaaaact actgattccg tggaggctgt ttaggctgtg   5580

ggctttgcta gacggaatcg atacacctga aaatatgatc aggtgtgttg ataacaatta   5640

cagttcacta gcattctgga gagcttggca tagaagctac aataagtggg ttgtccgtta   5700

catatatatt cctctaggtg gttcaaaaaa tagagttttg acatcactag cagtcttttc   5760

cttcgtagct atatggcatg acatcgaact aaagttatta ttatggggtt ggctaatagt   5820

tttgttcctc ttaccagaaa tttttgctac ccaaattttc tctcattata ccgacgcagt   5880

ctggtacaga cacgtttgcg ctgtcggtgc tgttttcaac atatgggtta tgatgatcgc   5940

taatcttttt ggattctgct tgggctctga cggtactaaa aaattactaa gcgatatgtt   6000

ctgtaccgta tctggtttca aatttgtaat tttggcaagc gttagtttat tcatcgcagt   6060

acaaataatg tttgaaatca gagaagaaga aaagaggcac ggaatttacc taaaatgctg   6120

aggatcccct tttcctttgt cgatatcatg taattagtta tgtcacgctt acattcacgc   6180

cctcctccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc   6240

cctatttatt ttttttaata gttatgttag tattaagaac gttatttata tttcaaattt   6300

ttcttttttt tctgtacaaa cgcgtgtacg catgtaacat tatactgaaa accttgcttg   6360

agaaggtttt gggacgctcg aaggcttcct agttctagag cggccgccac cgcggtggag   6420

ctccaattcg ccctatagtg agtcgtatta caattcactg gccgtcgttt tacaacgtcg   6480

tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc cccccttcgc   6540

cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct   6600

gaatggcgaa tggcgcgacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt   6660

tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt   6720

cccttccttt ctcgccacgt tcgccggtag tgttagacct gaacaaggtt tactaaaaat   6780

ccgtaaagaa cttcaattgt acgccaactt aaggcctcgt ccccgccggg tcacccggcc   6840

agcgacatgg aggcccagaa taccctcctt gacagtcttg acgtgcgcag ctcaggggca   6900

tgatgtgact gtcgcccgta catttagccc atacatcccc atgtataatc atttgcatcc   6960

atacattttg atggccgcac ggcgcgaagc aaaaattacg gctcctcgct gcagacctgc   7020

gagcagggaa acgctcccct cacagacgcg tgaattgtcc ccacgccgcg cccctgtaga   7080

gaaatataaa aggttaggat ttgccactga ggttcttctt tcatatactt ccttttaaaa   7140

tcttgctagg atacagttct cacatcacat ccgaacataa acaaccatgg gtaaaaagcc   7200

tgaactcacc gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga   7260

cctgatgcag ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg   7320

tggatatgtc ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta   7380

tcggcacttt gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaattcag   7440

cgagagcctg acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc   7500

tgaaaccgaa ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc   7560

ggccgatctt agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata   7620

cactacatgg cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac   7680

tgtgatggac gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg   7740

ggccgaggac tgccccgaag tccggcacct cgtgcacgcg gatttcggct ccaacaatgt   7800

cctgacggac aatggccgca taacagcggt cattgactgg agcgaggcga tgttcgggga   7860

ttcccaatac gaggtcgcca acatcttctt ctggaggccg tggttggctt gtatggagca   7920

gcagacgcgc tacttcgagc ggaggcatcc ggagcttgca ggatcgccgc ggctccgggc   7980

gtatatgctc cgcattggtc ttgaccaact ctatcagagc ttggttgacg gcaatttcga   8040

tgatgcagct tgggcgcagg gtcgatgcga cgcaatcgtc cgatccggag ccgggactgt   8100

cgggcgtaca caaatcgccc gcagaagcgc ggccgtctgg accgatggct gtgtagaagt   8160

actcgccgat agtggaaacc gacgccccag cactcgtccg agggcaaagg aataatcagt   8220

actgacaata aaaagattct tgttttcaag aacttgtcat ttgtatagtt tttttatatt   8280

gtagttgttc tattttaatc aaatgttagc gtgatttata ttttttttcg cctcgacatc   8340

atctgcccag atgcgaagtt aagtgcgcag aaagtaatat catgcgtcaa tcgtatgtga   8400

atgctggtcg ctatactgct gtcgattcga tactaacgcc gccatccagt gtcgacggat   8460

cctaggtgta cataaacttt ataaatgaaa ttcataatag aaacgacacg aaattacaaa   8520

atggaatatg ttcatagggt agacgaaact atatacgcaa tctacataca tttatcaaga   8580

aggagaaaaa ggaggatagt aaaggaatac aggtaagcaa attgatacta atggctcaac   8640

gtgataagga aaaagaattg cactttaaca ttaatattga caaggaggag ggcaccacac   8700

aaaaagttag gtgtaacaga aaatcatgaa actacgattc ctaatttgat attggaggat   8760

tttctctaaa aaaaaaaaaa tacaacaaat aaaaaacact caatgacctg accatttgat   8820

ggagtttaag tcaatacctt cttgaaccat ttcccataat ggtgaaagtt ccctcaagaa   8880

ttttactctg tcagaaacgg ccttacgacg tagtcgatat ggtgcactct cagtacaatc   8940

tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc tgacgcgccc   9000

tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt ctccgggagc   9060

tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg   9120

atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagga cggatcgctt   9180

gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg aatttactct   9240

gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa gaaggtagaa   9300

gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa caaaaagcgt   9360

actttacata tatatttatt agacaagaaa agcagattaa atagatatac attcgattaa   9420

cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac agacaagatg   9480

aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta gtatttgttg   9540

gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt ctttaatttc   9600

tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa ttataattat   9660

ttttatagca cgtgatgaaa aggacccagg tggcactttt cggggaaatg tgcgcggaac   9720

ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc   9780

ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt   9840

cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct   9900

ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga   9960

tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag  10020

cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca  10080

actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga  10140

aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag  10200

tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc  10260

tttttttcac aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa  10320

tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt  10380

gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg  10440

gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt  10500

tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg  10560

gccagatggt aagccctccc gtatcgtagt tatctacacg acgggcagtc aggcaactat  10620

ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact  10680

gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa  10740

aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt  10800

ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt  10860

ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg  10920

tttgccggat caagagctac caactctttt tccgaaggta actggcttca gcagagcgca  10980

gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt  11040

agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga  11100

ta                                                                 11102


