SEQUENCE LISTING

<110>   Novartis AG


<120>   PNEUMOCOCCAL RrgB EPITOPES AND CLADE COMBINATIONS
        
<130>   PAT054430-US-PSP

<160>   105

<170>   SeqWin99, version 1.02

<210>   1
<211>   665
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   1
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Gly Thr 
            20                  25                  30          

Thr Thr Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp 
        35                  40                  45              

Met Asp Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn 
    50                  55                  60                  

Lys Val Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met 
65                  70                  75                  80  

Phe Val Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln 
                85                  90                  95      

Thr Leu Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala 
            100                 105                 110         

Met Pro Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys 
        115                 120                 125             

Phe Asn Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile 
    130                 135                 140                 

His Ser Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly 
145                 150                 155                 160 

Ser Lys Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val 
                165                 170                 175     

Asp Ala His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp 
            180                 185                 190         

Lys Asp Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys 
        195                 200                 205             

Asp Thr Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile 
    210                 215                 220                 

Val Thr Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser 
225                 230                 235                 240 

Asp Arg Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val 
                245                 250                 255     

Thr Val Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu 
            260                 265                 270         

Val Ala Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys 
        275                 280                 285             

Val Asn Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala 
    290                 295                 300                 

Thr Leu Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val 
305                 310                 315                 320 

Thr Phe Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro 
                325                 330                 335     

Asn Lys Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val 
            340                 345                 350         

Asp Ala Thr Gly Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp 
        355                 360                 365             

Leu Val Asn Ala Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr 
    370                 375                 380                 

Thr Asp Lys Asn Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu 
385                 390                 395                 400 

Tyr Lys Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln 
                405                 410                 415     

Glu Ile Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu 
            420                 425                 430         

Asn Pro Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly 
        435                 440                 445             

Lys Lys Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala 
    450                 455                 460                 

Glu Phe Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg 
465                 470                 475                 480 

Lys Ala Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr 
                485                 490                 495     

Lys Asp Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala 
            500                 505                 510         

Gln Gln Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala 
        515                 520                 525             

Ala Tyr Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val 
    530                 535                 540                 

Ala Asp Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln 
545                 550                 555                 560 

Gly Arg Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu 
                565                 570                 575     

Glu Thr Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys 
            580                 585                 590         

Phe Glu Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu 
        595                 600                 605             

Tyr Thr Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys 
    610                 615                 620                 

Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala 
625                 630                 635                 640 

Val Ala Gly Ala Ala Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys 
                645                 650                 655     

Asn Asn Lys Asp Glu Asp Gln Leu Ala 
            660                 665 

<210>   2
<211>   644
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   2
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Asp Asn 
            20                  25                  30          

Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys 
        35                  40                  45              

Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro 
    50                  55                  60                  

Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val 
65                  70                  75                  80  

Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn 
                85                  90                  95      

Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp 
            100                 105                 110         

Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu 
        115                 120                 125             

Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys 
    130                 135                 140                 

Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala 
145                 150                 155                 160 

Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val 
                165                 170                 175     

Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val 
            180                 185                 190         

Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu 
        195                 200                 205             

Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser 
    210                 215                 220                 

Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly 
225                 230                 235                 240 

Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met 
                245                 250                 255     

Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Asn Asn Gly Phe Asn Leu 
            260                 265                 270         

Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp 
        275                 280                 285             

Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val 
    290                 295                 300                 

Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His 
305                 310                 315                 320 

Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln 
                325                 330                 335     

Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val 
            340                 345                 350         

Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly 
        355                 360                 365             

Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly 
    370                 375                 380                 

Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr 
385                 390                 395                 400 

Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn 
                405                 410                 415     

Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val 
            420                 425                 430         

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg 
        435                 440                 445             

Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr 
    450                 455                 460                 

Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala 
465                 470                 475                 480 

Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn 
                485                 490                 495     

Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln 
            500                 505                 510         

Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val 
        515                 520                 525             

Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln 
    530                 535                 540                 

Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile 
545                 550                 555                 560 

Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val 
                565                 570                 575     

Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val 
            580                 585                 590         

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Ile Pro 
        595                 600                 605             

Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala Val Ala Gly Ala Ala 
    610                 615                 620                 

Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu 
625                 630                 635                 640 

Asp Gln Leu Ala 
                

<210>   3
<211>   654
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   3
Met Lys Ser Ile Asn Lys Phe Leu Thr Ile Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Val Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Glu Gln 
            20                  25                  30          

Lys Thr Lys Thr Leu Thr Val His Lys Leu Leu Met Thr Asp Gln Glu 
        35                  40                  45              

Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr Thr Ala Gly Tyr Asp Gly 
    50                  55                  60                  

Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu Gln Gly Val Pro Gln Gly 
65                  70                  75                  80  

Val Thr Glu Ile Ser Gly Val Ala Phe Glu Leu Gln Ser Tyr Thr Gly 
                85                  90                  95      

Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr Asn Asp Ala Val Trp Thr 
            100                 105                 110         

Ala Val Asn Lys Gly Val Thr Thr Glu Thr Gly Val Lys Phe Asp Thr 
        115                 120                 125             

Glu Val Leu Gln Gly Thr Tyr Arg Leu Val Glu Val Arg Lys Glu Ser 
    130                 135                 140                 

Thr Tyr Val Gly Pro Asn Gly Lys Val Leu Thr Gly Met Lys Ala Val 
145                 150                 155                 160 

Pro Ala Leu Ile Thr Leu Pro Leu Val Asn Gln Asn Gly Val Val Glu 
                165                 170                 175     

Asn Ala His Val Tyr Pro Lys Asn Ser Glu Asp Lys Pro Thr Ala Thr 
            180                 185                 190         

Lys Thr Phe Asp Thr Ala Ala Gly Phe Val Asp Pro Gly Glu Lys Gly 
        195                 200                 205             

Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile Val Thr Thr Thr Ile Pro 
    210                 215                 220                 

Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp Ser Asp Glu Met Thr Glu 
225                 230                 235                 240 

Gly Leu Asp Tyr Asn Gly Asp Val Val Val Asn Tyr Asn Gly Gln Pro 
                245                 250                 255     

Leu Asp Asn Ser His Tyr Thr Leu Glu Ala Gly His Asn Gly Phe Ile 
            260                 265                 270         

Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala Ile Asn Gly Lys Asp Ala 
        275                 280                 285             

Glu Ala Thr Ile Thr Leu Lys Tyr Thr Ala Thr Leu Asn Ala Leu Ala 
    290                 295                 300                 

Val Ala Asp Val Pro Glu Ala Asn Asp Val Thr Phe His Tyr Gly Asn 
305                 310                 315                 320 

Asn Pro Gly His Gly Asn Thr Pro Lys Pro Asn Lys Pro Lys Asn Gly 
                325                 330                 335     

Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp Ala Lys Asp Ala Pro Ile 
            340                 345                 350         

Ala Gly Val Glu Val Thr Phe Asp Leu Val Asn Ala Gln Thr Gly Glu 
        355                 360                 365             

Val Val Lys Val Pro Gly His Glu Thr Gly Ile Val Leu Asn Gln Thr 
    370                 375                 380                 

Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu Asp Asn Asn Thr Glu Tyr 
385                 390                 395                 400 

Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Thr 
                405                 410                 415     

Ile Thr Glu Thr Gly Lys Ile Ala Val Lys Asn Trp Lys Asp Glu Asn 
            420                 425                 430         

Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly Lys 
        435                 440                 445             

Lys Phe Val Lys Val Asp Gln Lys Asp Glu Arg Leu Lys Glu Ala Gln 
    450                 455                 460                 

Phe Val Val Lys Asn Glu Gln Gly Lys Tyr Leu Ala Leu Lys Ser Ala 
465                 470                 475                 480 

Ala Gln Gln Ala Val Asn Glu Lys Ala Ala Ala Glu Ala Lys Gln Ala 
                485                 490                 495     

Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala Ala Asp Lys Asn Ala 
            500                 505                 510         

Ala Gln Ala Val Val Asp Ala Ala Gln Lys Thr Tyr Asn Asp Asn Tyr 
        515                 520                 525             

Arg Ala Ala Arg Phe Gly Tyr Val Glu Val Glu Arg Lys Glu Asp Ala 
    530                 535                 540                 

Leu Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser Gly Leu 
545                 550                 555                 560 

Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr Lys Ala Pro Glu Gly Phe 
                565                 570                 575     

Ala Lys Leu Gly Asp Val Lys Phe Glu Val Gly Ala Gly Ser Trp Asn 
            580                 585                 590         

Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp Ala Thr 
        595                 600                 605             

Lys Val Val Asn Lys Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly 
    610                 615                 620                 

Thr Ile Ile Phe Ala Val Ala Gly Ala Val Ile Met Gly Ile Ala Val 
625                 630                 635                 640 

Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu Asp Gln Leu Ala 
                645                 650                 

<210>   4
<211>   604
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Fragment of SEQ ID NO: 1

<400>   4
Ala Ala Thr Val Phe Ala Ala Gly Thr Thr Thr Thr Ser Val Thr Val 
1               5                   10                  15      

His Lys Leu Leu Ala Thr Asp Gly Asp Met Asp Lys Ile Ala Asn Glu 
            20                  25                  30          

Leu Glu Thr Gly Asn Tyr Ala Gly Asn Lys Val Gly Val Leu Pro Ala 
        35                  40                  45              

Asn Ala Lys Glu Ile Ala Gly Val Met Phe Val Trp Thr Asn Thr Asn 
    50                  55                  60                  

Asn Glu Ile Ile Asp Glu Asn Gly Gln Thr Leu Gly Val Asn Ile Asp 
65                  70                  75                  80  

Pro Gln Thr Phe Lys Leu Ser Gly Ala Met Pro Ala Thr Ala Met Lys 
                85                  90                  95      

Lys Leu Thr Glu Ala Glu Gly Ala Lys Phe Asn Thr Ala Asn Leu Pro 
            100                 105                 110         

Ala Ala Lys Tyr Lys Ile Tyr Glu Ile His Ser Leu Ser Thr Tyr Val 
        115                 120                 125             

Gly Glu Asp Gly Ala Thr Leu Thr Gly Ser Lys Ala Val Pro Ile Glu 
    130                 135                 140                 

Ile Glu Leu Pro Leu Asn Asp Val Val Asp Ala His Val Tyr Pro Lys 
145                 150                 155                 160 

Asn Thr Glu Ala Lys Pro Lys Ile Asp Lys Asp Phe Lys Gly Lys Ala 
                165                 170                 175     

Asn Pro Asp Thr Pro Arg Val Asp Lys Asp Thr Pro Val Asn His Gln 
            180                 185                 190         

Val Gly Asp Val Val Glu Tyr Glu Ile Val Thr Lys Ile Pro Ala Leu 
        195                 200                 205             

Ala Asn Tyr Ala Thr Ala Asn Trp Ser Asp Arg Met Thr Glu Gly Leu 
    210                 215                 220                 

Ala Phe Asn Lys Gly Thr Val Lys Val Thr Val Asp Asp Val Ala Leu 
225                 230                 235                 240 

Glu Ala Gly Asp Tyr Ala Leu Thr Glu Val Ala Thr Gly Phe Asp Leu 
                245                 250                 255     

Lys Leu Thr Asp Ala Gly Leu Ala Lys Val Asn Asp Gln Asn Ala Glu 
            260                 265                 270         

Lys Thr Val Lys Ile Thr Tyr Ser Ala Thr Leu Asn Asp Lys Ala Ile 
        275                 280                 285             

Val Glu Val Pro Glu Ser Asn Asp Val Thr Phe Asn Tyr Gly Asn Asn 
    290                 295                 300                 

Pro Asp His Gly Asn Thr Pro Lys Pro Asn Lys Pro Asn Glu Asn Gly 
305                 310                 315                 320 

Asp Leu Thr Leu Thr Lys Thr Trp Val Asp Ala Thr Gly Ala Pro Ile 
                325                 330                 335     

Pro Ala Gly Ala Glu Ala Thr Phe Asp Leu Val Asn Ala Gln Thr Gly 
            340                 345                 350         

Lys Val Val Gln Thr Val Thr Leu Thr Thr Asp Lys Asn Thr Val Thr 
        355                 360                 365             

Val Asn Gly Leu Asp Lys Asn Thr Glu Tyr Lys Phe Val Glu Arg Ser 
    370                 375                 380                 

Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Glu Ile Thr Thr Ala Gly Glu 
385                 390                 395                 400 

Ile Ala Val Lys Asn Trp Lys Asp Glu Asn Pro Lys Pro Leu Asp Pro 
                405                 410                 415     

Thr Glu Pro Lys Val Val Thr Tyr Gly Lys Lys Phe Val Lys Val Asn 
            420                 425                 430         

Asp Lys Asp Asn Arg Leu Ala Gly Ala Glu Phe Val Ile Ala Asn Ala 
        435                 440                 445             

Asp Asn Ala Gly Gln Tyr Leu Ala Arg Lys Ala Asp Lys Val Ser Gln 
    450                 455                 460                 

Glu Glu Lys Gln Leu Val Val Thr Thr Lys Asp Ala Leu Asp Arg Ala 
465                 470                 475                 480 

Val Ala Ala Tyr Asn Ala Leu Thr Ala Gln Gln Gln Thr Gln Gln Glu 
                485                 490                 495     

Lys Glu Lys Val Asp Lys Ala Gln Ala Ala Tyr Asn Ala Ala Val Ile 
            500                 505                 510         

Ala Ala Asn Asn Ala Phe Glu Trp Val Ala Asp Lys Asp Asn Glu Asn 
        515                 520                 525             

Val Val Lys Leu Val Ser Asp Ala Gln Gly Arg Phe Glu Ile Thr Gly 
    530                 535                 540                 

Leu Leu Ala Gly Thr Tyr Tyr Leu Glu Glu Thr Lys Gln Pro Ala Gly 
545                 550                 555                 560 

Tyr Ala Leu Leu Thr Ser Arg Gln Lys Phe Glu Val Thr Ala Thr Ser 
                565                 570                 575     

Tyr Ser Ala Thr Gly Gln Gly Ile Glu Tyr Thr Ala Gly Ser Gly Lys 
            580                 585                 590         

Asp Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr 
        595                 600                 

<210>   5
<211>   583
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Fragment of SEQ ID NO: 2

<400>   5
Ala Ala Thr Val Phe Ala Ala Asp Asn Val Ser Thr Ala Pro Asp Ala 
1               5                   10                  15      

Val Thr Lys Thr Leu Thr Ile His Lys Leu Leu Leu Ser Glu Asp Asp 
            20                  25                  30          

Leu Lys Thr Trp Asp Thr Asn Gly Pro Lys Gly Tyr Asp Gly Thr Gln 
        35                  40                  45              

Ser Ser Leu Lys Asp Leu Thr Gly Val Val Ala Glu Glu Ile Pro Asn 
    50                  55                  60                  

Val Tyr Phe Glu Leu Gln Lys Tyr Asn Leu Thr Asp Gly Lys Glu Lys 
65                  70                  75                  80  

Glu Asn Leu Lys Asp Asp Ser Lys Trp Thr Thr Val His Gly Gly Leu 
                85                  90                  95      

Thr Thr Lys Asp Gly Leu Lys Ile Glu Thr Ser Thr Leu Lys Gly Val 
            100                 105                 110         

Tyr Arg Ile Arg Glu Asp Arg Thr Lys Thr Thr Tyr Val Gly Pro Asn 
        115                 120                 125             

Gly Gln Val Leu Thr Gly Ser Lys Ala Val Pro Ala Leu Val Thr Leu 
    130                 135                 140                 

Pro Leu Val Asn Asn Asn Gly Thr Val Ile Asp Ala His Val Phe Pro 
145                 150                 155                 160 

Lys Asn Ser Tyr Asn Lys Pro Val Val Asp Lys Arg Ile Ala Asp Thr 
                165                 170                 175     

Leu Asn Tyr Asn Asp Gln Asn Gly Leu Ser Ile Gly Thr Lys Ile Pro 
            180                 185                 190         

Tyr Val Val Asn Thr Thr Ile Pro Ser Asn Ala Thr Phe Ala Thr Ser 
        195                 200                 205             

Phe Trp Ser Asp Glu Met Thr Glu Gly Leu Thr Tyr Asn Glu Asp Val 
    210                 215                 220                 

Thr Ile Thr Leu Asn Asn Val Ala Met Asp Gln Ala Asp Tyr Glu Val 
225                 230                 235                 240 

Thr Lys Gly Asn Asn Gly Phe Asn Leu Lys Leu Thr Glu Ala Gly Leu 
                245                 250                 255     

Ala Lys Ile Asn Gly Lys Asp Ala Asp Gln Lys Ile Gln Ile Thr Tyr 
            260                 265                 270         

Ser Ala Thr Leu Asn Ser Leu Ala Val Ala Asp Ile Pro Glu Ser Asn 
        275                 280                 285             

Asp Ile Thr Tyr His Tyr Gly Asn His Gln Asp His Gly Asn Thr Pro 
    290                 295                 300                 

Lys Pro Thr Lys Pro Asn Asn Gly Gln Ile Thr Val Thr Lys Thr Trp 
305                 310                 315                 320 

Asp Ser Gln Pro Ala Pro Glu Gly Val Lys Ala Thr Val Gln Leu Val 
                325                 330                 335     

Asn Ala Lys Thr Gly Glu Lys Val Gly Ala Pro Val Glu Leu Ser Glu 
            340                 345                 350         

Asn Asn Trp Thr Tyr Thr Trp Ser Gly Leu Asp Asn Ser Ile Glu Tyr 
        355                 360                 365             

Lys Val Glu Glu Glu Tyr Asn Gly Tyr Ser Ala Glu Tyr Thr Val Glu 
    370                 375                 380                 

Ser Lys Gly Lys Leu Gly Val Lys Asn Trp Lys Asp Asn Asn Pro Ala 
385                 390                 395                 400 

Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly Lys Lys Phe 
                405                 410                 415     

Val Lys Val Asp Gln Lys Asp Thr Arg Leu Glu Asn Ala Gln Phe Val 
            420                 425                 430         

Val Lys Lys Ala Asp Ser Asn Lys Tyr Ile Ala Phe Lys Ser Thr Ala 
        435                 440                 445             

Gln Gln Ala Ala Asp Glu Lys Ala Ala Ala Thr Ala Lys Gln Lys Leu 
    450                 455                 460                 

Asp Ala Ala Val Ala Ala Tyr Thr Asn Ala Ala Asp Lys Gln Ala Ala 
465                 470                 475                 480 

Gln Ala Leu Val Asp Gln Ala Gln Gln Glu Tyr Asn Val Ala Tyr Lys 
                485                 490                 495     

Glu Ala Lys Phe Gly Tyr Val Glu Val Ala Gly Lys Asp Glu Ala Met 
            500                 505                 510         

Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser Gly Leu Ala 
        515                 520                 525             

Ala Gly Thr Tyr Lys Leu Glu Glu Ile Lys Ala Pro Glu Gly Phe Ala 
    530                 535                 540                 

Lys Ile Asp Asp Val Glu Phe Val Val Gly Ala Gly Ser Trp Asn Gln 
545                 550                 555                 560 

Gly Glu Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp Ala Thr Lys 
                565                 570                 575     

Val Val Asn Lys Lys Ile Thr 
            580             

<210>   6
<211>   587
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Fragment of SEQ ID NO: 3

<400>   6
Ala Glu Gln Lys Thr Lys Thr Leu Thr Val His Lys Leu Leu Met Thr 
1               5                   10                  15      

Asp Gln Glu Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr Thr Ala Gly 
            20                  25                  30          

Tyr Asp Gly Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu Gln Gly Val 
        35                  40                  45              

Pro Gln Gly Val Thr Glu Ile Ser Gly Val Ala Phe Glu Leu Gln Ser 
    50                  55                  60                  

Tyr Thr Gly Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr Asn Asp Ala 
65                  70                  75                  80  

Val Trp Thr Ala Val Asn Lys Gly Val Thr Thr Glu Thr Gly Val Lys 
                85                  90                  95      

Phe Asp Thr Glu Val Leu Gln Gly Thr Tyr Arg Leu Val Glu Val Arg 
            100                 105                 110         

Lys Glu Ser Thr Tyr Val Gly Pro Asn Gly Lys Val Leu Thr Gly Met 
        115                 120                 125             

Lys Ala Val Pro Ala Leu Ile Thr Leu Pro Leu Val Asn Gln Asn Gly 
    130                 135                 140                 

Val Val Glu Asn Ala His Val Tyr Pro Lys Asn Ser Glu Asp Lys Pro 
145                 150                 155                 160 

Thr Ala Thr Lys Thr Phe Asp Thr Ala Ala Gly Phe Val Asp Pro Gly 
                165                 170                 175     

Glu Lys Gly Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile Val Thr Thr 
            180                 185                 190         

Thr Ile Pro Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp Ser Asp Glu 
        195                 200                 205             

Met Thr Glu Gly Leu Asp Tyr Asn Gly Asp Val Val Val Asn Tyr Asn 
    210                 215                 220                 

Gly Gln Pro Leu Asp Asn Ser His Tyr Thr Leu Glu Ala Gly His Asn 
225                 230                 235                 240 

Gly Phe Ile Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala Ile Asn Gly 
                245                 250                 255     

Lys Asp Ala Glu Ala Thr Ile Thr Leu Lys Tyr Thr Ala Thr Leu Asn 
            260                 265                 270         

Ala Leu Ala Val Ala Asp Val Pro Glu Ala Asn Asp Val Thr Phe His 
        275                 280                 285             

Tyr Gly Asn Asn Pro Gly His Gly Asn Thr Pro Lys Pro Asn Lys Pro 
    290                 295                 300                 

Lys Asn Gly Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp Ala Lys Asp 
305                 310                 315                 320 

Ala Pro Ile Ala Gly Val Glu Val Thr Phe Asp Leu Val Asn Ala Gln 
                325                 330                 335     

Thr Gly Glu Val Val Lys Val Pro Gly His Glu Thr Gly Ile Val Leu 
            340                 345                 350         

Asn Gln Thr Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu Asp Asn Asn 
        355                 360                 365             

Thr Glu Tyr Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr Ser Ala Asp 
    370                 375                 380                 

Tyr Gln Thr Ile Thr Glu Thr Gly Lys Ile Ala Val Lys Asn Trp Lys 
385                 390                 395                 400 

Asp Glu Asn Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr 
                405                 410                 415     

Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Glu Arg Leu Lys 
            420                 425                 430         

Glu Ala Gln Phe Val Val Lys Asn Glu Gln Gly Lys Tyr Leu Ala Leu 
        435                 440                 445             

Lys Ser Ala Ala Gln Gln Ala Val Asn Glu Lys Ala Ala Ala Glu Ala 
    450                 455                 460                 

Lys Gln Ala Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala Ala Asp 
465                 470                 475                 480 

Lys Asn Ala Ala Gln Ala Val Val Asp Ala Ala Gln Lys Thr Tyr Asn 
                485                 490                 495     

Asp Asn Tyr Arg Ala Ala Arg Phe Gly Tyr Val Glu Val Glu Arg Lys 
            500                 505                 510         

Glu Asp Ala Leu Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile 
        515                 520                 525             

Ser Gly Leu Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr Lys Ala Pro 
    530                 535                 540                 

Glu Gly Phe Ala Lys Leu Gly Asp Val Lys Phe Glu Val Gly Ala Gly 
545                 550                 555                 560 

Ser Trp Asn Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn 
                565                 570                 575     

Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr 
            580                 585         

<210>   7
<211>   6
<212>   PRT
<213>   Artificial

<220>
<223>   linker amino acid sequence

<400>   7
Gly Ser Gly Gly Gly Gly 
1               5       

<210>   8
<211>   8
<212>   PRT
<213>   Artificial

<220>
<223>   linker amino acid sequence

<400>   8
Gly Ser Gly Ser Gly Gly Gly Gly 
1               5               

<210>   9
<211>   6
<212>   PRT
<213>   Artificial

<220>
<223>   hexa-His tag

<400>   9
His His His His His His 
1               5       

<210>   10
<211>   8
<212>   PRT
<213>   Artificial

<220>
<223>   linker

<400>   10
Leu Gly Gly Ser Gly Gly Gly Gly 
1               5               

<210>   11
<211>   1801
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   RrgB I-II-III

<400>   11
Met Ala Ser Ala Ala Thr Val Phe Ala Ala Gly Thr Thr Thr Thr Ser 
1               5                   10                  15      

Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp Met Asp Lys Ile 
            20                  25                  30          

Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn Lys Val Gly Val 
        35                  40                  45              

Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met Phe Val Trp Thr 
    50                  55                  60                  

Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln Thr Leu Gly Val 
65                  70                  75                  80  

Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala Met Pro Ala Thr 
                85                  90                  95      

Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys Phe Asn Thr Ala 
            100                 105                 110         

Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile His Ser Leu Ser 
        115                 120                 125             

Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly Ser Lys Ala Val 
    130                 135                 140                 

Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val Asp Ala His Val 
145                 150                 155                 160 

Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp Lys Asp Phe Lys 
                165                 170                 175     

Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys Asp Thr Pro Val 
            180                 185                 190         

Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile Val Thr Lys Ile 
        195                 200                 205             

Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser Asp Arg Met Thr 
    210                 215                 220                 

Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val Thr Val Asp Asp 
225                 230                 235                 240 

Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu Val Ala Thr Gly 
                245                 250                 255     

Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys Val Asn Asp Gln 
            260                 265                 270         

Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala Thr Leu Asn Asp 
        275                 280                 285             

Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val Thr Phe Asn Tyr 
    290                 295                 300                 

Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro Asn Lys Pro Asn 
305                 310                 315                 320 

Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val Asp Ala Thr Gly 
                325                 330                 335     

Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp Leu Val Asn Ala 
            340                 345                 350         

Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr Thr Asp Lys Asn 
        355                 360                 365             

Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu Tyr Lys Phe Val 
    370                 375                 380                 

Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Glu Ile Thr Thr 
385                 390                 395                 400 

Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu Asn Pro Lys Pro 
                405                 410                 415     

Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly Lys Lys Phe Val 
            420                 425                 430         

Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala Glu Phe Val Ile 
        435                 440                 445             

Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg Lys Ala Asp Lys 
    450                 455                 460                 

Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr Lys Asp Ala Leu 
465                 470                 475                 480 

Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala Gln Gln Gln Thr 
                485                 490                 495     

Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala Ala Tyr Asn Ala 
            500                 505                 510         

Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val Ala Asp Lys Asp 
        515                 520                 525             

Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln Gly Arg Phe Glu 
    530                 535                 540                 

Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu Glu Thr Lys Gln 
545                 550                 555                 560 

Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys Phe Glu Val Thr 
                565                 570                 575     

Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu Tyr Thr Ala Gly 
            580                 585                 590         

Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Gly 
        595                 600                 605             

Ser Gly Ser Gly Gly Gly Gly Ala Ala Thr Val Phe Ala Ala Asp Asn 
    610                 615                 620                 

Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys 
625                 630                 635                 640 

Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro 
                645                 650                 655     

Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val 
            660                 665                 670         

Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn 
        675                 680                 685             

Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp 
    690                 695                 700                 

Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu 
705                 710                 715                 720 

Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys 
                725                 730                 735     

Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala 
            740                 745                 750         

Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val 
        755                 760                 765             

Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val 
    770                 775                 780                 

Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu 
785                 790                 795                 800 

Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser 
                805                 810                 815     

Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly 
            820                 825                 830         

Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met 
        835                 840                 845             

Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Asn Asn Gly Phe Asn Leu 
    850                 855                 860                 

Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp 
865                 870                 875                 880 

Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val 
                885                 890                 895     

Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His 
            900                 905                 910         

Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln 
        915                 920                 925             

Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val 
    930                 935                 940                 

Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly 
945                 950                 955                 960 

Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly 
                965                 970                 975     

Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr 
            980                 985                 990         

Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn 
        995                 1000                1005            

Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val 
    1010                1015                1020                

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg 
1025                1030                1035                1040

Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr 
                1045                1050                1055    

Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala 
            1060                1065                1070        

Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn 
        1075                1080                1085            

Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln 
    1090                1095                1100                

Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val 
1105                1110                1115                1120

Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln 
                1125                1130                1135    

Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile 
            1140                1145                1150        

Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val 
        1155                1160                1165            

Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val 
    1170                1175                1180                

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Leu Gly 
1185                1190                1195                1200

Gly Ser Gly Gly Gly Gly Ala Glu Gln Lys Thr Lys Thr Leu Thr Val 
                1205                1210                1215    

His Lys Leu Leu Met Thr Asp Gln Glu Leu Asp Ala Trp Asn Ser Asp 
            1220                1225                1230        

Ala Ile Thr Thr Ala Gly Tyr Asp Gly Ser Gln Asn Phe Glu Gln Phe 
        1235                1240                1245            

Lys Gln Leu Gln Gly Val Pro Gln Gly Val Thr Glu Ile Ser Gly Val 
    1250                1255                1260                

Ala Phe Glu Leu Gln Ser Tyr Thr Gly Pro Gln Gly Lys Glu Gln Glu 
1265                1270                1275                1280

Asn Leu Thr Asn Asp Ala Val Trp Thr Ala Val Asn Lys Gly Val Thr 
                1285                1290                1295    

Thr Glu Thr Gly Val Lys Phe Asp Thr Glu Val Leu Gln Gly Thr Tyr 
            1300                1305                1310        

Arg Leu Val Glu Val Arg Lys Glu Ser Thr Tyr Val Gly Pro Asn Gly 
        1315                1320                1325            

Lys Val Leu Thr Gly Met Lys Ala Val Pro Ala Leu Ile Ile Leu Pro 
    1330                1335                1340                

Leu Val Asn Gln Asn Gly Val Val Glu Asn Ala His Val Tyr Pro Lys 
1345                1350                1355                1360

Asn Ser Glu Asp Lys Pro Thr Ala Thr Lys Thr Phe Asp Thr Ala Ala 
                1365                1370                1375    

Gly Phe Val Asp Pro Gly Glu Lys Gly Leu Ala Ile Gly Thr Lys Val 
            1380                1385                1390        

Pro Tyr Ile Val Thr Thr Thr Ile Pro Lys Asn Ser Thr Leu Ala Thr 
        1395                1400                1405            

Ala Phe Trp Ser Asp Glu Met Thr Glu Gly Leu Asp Tyr Asn Gly Asp 
    1410                1415                1420                

Val Val Val Asn Tyr Asn Gly Gln Pro Leu Asp Asn Ser His Tyr Thr 
1425                1430                1435                1440

Leu Glu Ala Gly His Asn Gly Phe Ile Leu Lys Leu Asn Glu Lys Gly 
                1445                1450                1455    

Leu Glu Ala Ile Asn Gly Lys Asp Ala Glu Ala Thr Ile Thr Leu Lys 
            1460                1465                1470        

Tyr Thr Ala Thr Leu Asn Ala Leu Ala Val Ala Asp Val Pro Glu Ala 
        1475                1480                1485            

Asn Asp Val Thr Phe His Tyr Gly Asn Asn Pro Gly His Gly Asn Thr 
    1490                1495                1500                

Pro Lys Pro Asn Lys Pro Lys Asn Gly Glu Leu Thr Ile Thr Lys Thr 
1505                1510                1515                1520

Trp Ala Asp Ala Lys Asp Ala Pro Ile Ala Gly Val Glu Val Thr Phe 
                1525                1530                1535    

Asp Leu Val Asn Ala Gln Thr Gly Glu Val Val Lys Val Pro Gly His 
            1540                1545                1550        

Glu Thr Gly Ile Val Leu Asn Gln Thr Asn Asn Trp Thr Phe Thr Ala 
        1555                1560                1565            

Thr Gly Leu Asp Asn Asn Thr Glu Tyr Lys Phe Val Glu Arg Thr Ile 
    1570                1575                1580                

Lys Gly Tyr Ser Ala Asp Tyr Gln Thr Ile Thr Glu Thr Gly Lys Ile 
1585                1590                1595                1600

Ala Val Lys Asn Trp Lys Asp Glu Asn Pro Glu Pro Ile Asn Pro Glu 
                1605                1610                1615    

Glu Pro Arg Val Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln 
            1620                1625                1630        

Lys Asp Glu Arg Leu Lys Glu Ala Gln Phe Val Val Lys Asn Glu Gln 
        1635                1640                1645            

Gly Lys Tyr Leu Ala Leu Lys Ser Ala Ala Gln Gln Ala Val Asn Glu 
    1650                1655                1660                

Lys Ala Ala Ala Glu Ala Lys Gln Ala Leu Asp Ala Ala Ile Ala Ala 
1665                1670                1675                1680

Tyr Thr Asn Ala Ala Asp Lys Asn Ala Ala Gln Ala Val Val Asp Ala 
                1685                1690                1695    

Ala Gln Lys Thr Tyr Asn Asp Asn Tyr Arg Ala Ala Arg Phe Gly Tyr 
            1700                1705                1710        

Val Glu Val Glu Arg Lys Glu Asp Ala Leu Val Leu Thr Ser Asn Thr 
        1715                1720                1725            

Asp Gly Gln Phe Gln Ile Ser Gly Leu Ala Ala Gly Ser Tyr Thr Leu 
    1730                1735                1740                

Glu Glu Thr Lys Ala Pro Glu Gly Phe Ala Lys Leu Gly Asp Val Lys 
1745                1750                1755                1760

Phe Glu Val Gly Ala Gly Ser Trp Asn Gln Gly Asp Phe Asn Tyr Leu 
                1765                1770                1775    

Lys Asp Val Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile 
            1780                1785                1790        

Thr Leu Gly His His His His His His 
        1795                1800    

<210>   12
<211>   5403
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence encoding SEQ ID NO: 11

<400>   12
atggctagcg ctgcaacagt ttttgcggct gggacgacaa caacatctgt taccgttcat   60
aaactattgg caacagatgg ggatatggat aaaattgcaa atgagttaga aacaggtaac   120
tatgctggta ataaagtggg tgttctacct gcaaatgcaa aagaaattgc cggtgttatg   180
ttcgtttgga caaatactaa taatgaaatt attgatgaaa atggccaaac tctaggagtg   240
aatattgatc cacaaacatt taaactctca ggggcaatgc cggcaactgc aatgaaaaaa   300
ttaacagaag ctgaaggagc taaatttaac acggcaaatt taccagctgc taagtataaa   360
atttatgaaa ttcacagttt atcaacttat gtcggtgaag atggagcaac cttaacaggt   420
tctaaagcag ttccaattga aattgaatta ccattgaacg atgttgtgga tgcgcatgtg   480
tatccaaaaa atacagaagc aaagccaaaa attgataaag atttcaaagg taaagcaaat   540
ccagatacac cacgtgtaga taaagataca cctgtgaacc accaagttgg agatgttgta   600
gagtacgaaa ttgttacaaa aattccagca cttgctaatt atgcaacagc aaactggagc   660
gatagaatga ctgaaggttt ggcattcaac aaaggtacag tgaaagtaac tgttgatgat   720
gttgcacttg aagcaggtga ttatgctcta acagaagtag caactggttt tgatttgaaa   780
ttaacagatg ctggtttagc taaagtgaat gaccaaaacg ctgaaaaaac tgtgaaaatc   840
acttattcgg caacattgaa tgacaaagca attgtagaag taccagaatc taatgatgta   900
acatttaact atggtaataa tccagatcac gggaatactc caaagccgaa taagccaaat   960
gaaaacggcg atttgacatt gaccaagaca tgggttgatg ctacaggtgc accaattccg   1020
gctggagctg aagcaacgtt cgatttggtt aatgctcaga ctggtaaagt tgtacaaact   1080
gtaactttga caacagacaa aaatacagtt actgttaacg gattggataa aaatacagaa   1140
tataaattcg ttgaacgtag tataaaaggg tattcagcag attatcaaga aatcactaca   1200
gctggagaaa ttgctgtcaa gaactggaaa gacgaaaatc caaaaccact tgatccaaca   1260
gagccaaaag ttgttacata tggtaaaaag tttgtcaaag ttaatgataa agataatcgt   1320
ttagctgggg cagaatttgt aattgcaaat gctgataatg ctggtcaata tttagcacgt   1380
aaagcagata aagtgagtca agaagagaag cagttggttg ttacaacaaa ggatgcttta   1440
gatagagcag ttgctgctta taacgctctt actgcacaac aacaaactca gcaagaaaaa   1500
gagaaagttg acaaagctca agctgcttat aatgctgctg tgattgctgc caacaatgca   1560
tttgaatggg tggcagataa ggacaatgaa aatgttgtga aattagtttc tgatgcacaa   1620
ggtcgctttg aaattacagg ccttcttgca ggtacatatt acttagaaga aacaaaacag   1680
cctgctggtt atgcattact aactagccgt cagaaatttg aagtcactgc aacttcttat   1740
tcagcgactg gacaaggcat tgagtatact gctggttcag gtaaagatga cgctacaaaa   1800
gtagtcaaca aaaaaatcac tggatccggc agcggtggcg gtggcgctgc aacagttttt   1860
gcggcggaca atgttagtac agcaccagat gctgttacta aaactttaac aatccataag   1920
ttactgctct cagaagatga tttaaagact tgggatacaa acggtcctaa aggatatgat   1980
ggaactcaat ctagtttaaa agatttaact ggagttgtag ctgaggaaat tccaaatgta   2040
tactttgaat tacaaaagta taatttgact gatggtaagg aaaaagaaaa tcttaaagat   2100
gatagtaaat ggacaacagt tcatggtggt ttgacaacta aagatggact taaaattgaa   2160
accagtactc ttaaaggtgt gtatcgtatt cgtgaggata gaacaaagac tacctatgtt   2220
ggtcctaatg ggcaagtatt aacaggttca aaagccgtac ctgctcttgt aactcttcca   2280
cttgttaaca ataatggtac agtaattgat gcacatgttt tccctaaaaa ttcatataat   2340
aaaccagttg tagataaaag aattgctgat actttgaatt ataacgatca aaatggtctg   2400
tctatcggta ctaaaatccc atatgttgtt aatacaacaa ttccaagtaa tgcaacattt   2460
gcaacttcat tttggtcaga tgaaatgaca gaaggtctaa cttataatga agatgtaaca   2520
attactttga ataatgtagc tatggatcaa gctgattatg aagtcactaa aggaaataat   2580
ggctttaact taaaattaac agaagcaggt ttagctaaaa ttaatggtaa ggatgcagac   2640
caaaaaatcc aaattactta ctcagctact ttgaactcac ttgctgttgc agacattcct   2700
gaaagtaacg atattacata tcattacgga aatcatcaag atcatgggaa tactccaaaa   2760
ccaactaaac ctaataatgg tcaaattaca gtaactaaga catgggacag tcaacctgct   2820
cctgaggggg tgaaagcgac tgttcaactt gtaaatgcca agactggtga gaaagtcggt   2880
gctcctgtag aactttcaga aaataattgg acatatactt ggagtggtct agataattct   2940
attgaataca aagttgaaga agaatataat ggatactcag ctgaatacac agtagagagc   3000
aaagggaagt tgggggtaaa aaactggaaa gataataacc cagctccaat caatcctgaa   3060
gaaccacgtg taaaaacata cggtaaaaag tttgtcaaag tagaccaaaa agatactcgt   3120
ctagaaaatg cgcagttcgt tgttaaaaaa gcagatagca ataaatatat tgcctttaag   3180
tcaactgcac aacaagctgc agatgaaaaa gcagcagcaa ctgcaaaaca aaaattggat   3240
gcagcggtag cagcttacac aaatgctgca gataagcaag ccgctcaagc tctagtagat   3300
caagcacagc aagaatacaa tgtagcttac aaagaagcca aatttggtta tgttgaagta   3360
gctggaaaag atgaagcaat ggttcttact tctaatacgg atggtcaatt ccaaatttca   3420
ggtcttgctg ctggtactta taaattagaa gaaattaaag ctccagaagg ttttgcgaaa   3480
attgatgatg tagaatttgt tgttggagca ggttcttgga atcaaggtga gtttaattac   3540
ttaaaagatg ttcaaaagaa tgacgctaca aaagtagtca acaaaaaaat cactctcgag   3600
ggcagcggtg gcggtggcgc ggaacaaaaa actaagacac ttacagttca taaattattg   3660
atgacagatc aagagcttga cgcttggaat tctgatgcga ttactactgc aggttatgac   3720
ggttcgcaaa attttgaaca gttcaaacaa cttcaaggtg ttccacaagg agtaaccgaa   3780
atctctggtg ttgcattcga gttacagagt tatacgggtc ctcaaggaaa agaacaagaa   3840
aatttaacga atgatgcggt ttggactgcg gttaataaag gtgtgacgac tgaaacgggt   3900
gttaaatttg atactgaagt tttacaaggg acatatcgtc ttgtcgaagt acgtaaagaa   3960
tcgacttatg tcggtccaaa tggtaaagtt ttaacaggta tgaaagctgt tcctgcttta   4020
attattctgc cgcttgtaaa ccaaaatggt gttgtagaaa atgcacatgt ctatccaaag   4080
aattctgaag acaaacctac agcaacgaaa acatttgata ctgcagcagg tttcgtagat   4140
ccaggtgaaa aaggtttagc aattggcact aaggtaccgt atattgttac aacaactatt   4200
ccgaaaaact caactcttgc aacagctttc tggtcagatg aaatgacaga aggtctagat   4260
tataatggtg atgtagttgt taattataat ggtcaaccgc ttgataattc tcattacaca   4320
ttagaagcag gtcataatgg ctttatcttg aagttaaatg aaaaaggtct ggaagcaatc   4380
aacggtaaag atgcagaagc aacaattacg ttgaagtata ctgcaacttt aaatgctctt   4440
gctgttgctg atgtgccaga agcgaatgat gtaacattcc attatggaaa caacccaggt   4500
catggtaaca ctccaaaacc aaacaaacct aaaaacggtg aacttacaat tactaaaaca   4560
tgggctgatg ctaaagatgc tcctatagca ggtgtagaag taacttttga tttggtaaat   4620
gctcagacag gtgaggtcgt taaagtacct ggacatgaaa caggtattgt attgaatcaa   4680
acaaataatt ggacatttac tgctacaggt cttgataata atacagaata taaatttgtt   4740
gaacggacaa ttaagggata ttctgcagat taccaaacaa ttactgaaac aggaaaaatt   4800
gctgttaaaa actggaaaga tgaaaatcca gaaccaataa atcctgaaga gccacgtgta   4860
aaaacatatg gtaaaaaatt cgttaaggtt gaccaaaaag acgaacgctt aaaagaagca   4920
caattcgttg tgaagaatga gcaagggaaa tatcttgcac tcaaatctgc agcacaacaa   4980
gctgtaaatg agaaagctgc cgcagaagcg aaacaagcgc tagatgcagc gatagcagcc   5040
tatacaaatg ctgcagataa aaatgcagca caagctgtag tagatgctgc gcaaaaaaca   5100
tataatgaca attacagagc agctagattt ggctatgtag aagtagagag aaaagaagat   5160
gcgttagttc ttacttctaa cactgatggt caattccaaa tttcaggtct tgctgctgga   5220
agctacacgt tggaagaaac aaaagctcca gaaggctttg caaaacttgg agatgtgaag   5280
tttgaggttg gagcaggttc ttggaatcaa ggtgatttca attatttaaa agatgttcag   5340
aagaacgacg ctacaaaagt agtcaacaaa aaaatcacgc tcgagcacca ccaccaccac   5400
cac                                                                 5403

<210>   13
<211>   1801
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   RrgB I-III-II

<400>   13
Met Ala Ser Ala Ala Thr Val Phe Ala Ala Gly Thr Thr Thr Thr Ser 
1               5                   10                  15      

Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp Met Asp Lys Ile 
            20                  25                  30          

Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn Lys Val Gly Val 
        35                  40                  45              

Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met Phe Val Trp Thr 
    50                  55                  60                  

Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln Thr Leu Gly Val 
65                  70                  75                  80  

Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala Met Pro Ala Thr 
                85                  90                  95      

Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys Phe Asn Thr Ala 
            100                 105                 110         

Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile His Ser Leu Ser 
        115                 120                 125             

Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly Ser Lys Ala Val 
    130                 135                 140                 

Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val Asp Ala His Val 
145                 150                 155                 160 

Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp Lys Asp Phe Lys 
                165                 170                 175     

Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys Asp Thr Pro Val 
            180                 185                 190         

Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile Val Thr Lys Ile 
        195                 200                 205             

Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser Asp Arg Met Thr 
    210                 215                 220                 

Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val Thr Val Asp Asp 
225                 230                 235                 240 

Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu Val Ala Thr Gly 
                245                 250                 255     

Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys Val Asn Asp Gln 
            260                 265                 270         

Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala Thr Leu Asn Asp 
        275                 280                 285             

Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val Thr Phe Asn Tyr 
    290                 295                 300                 

Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro Asn Lys Pro Asn 
305                 310                 315                 320 

Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val Asp Ala Thr Gly 
                325                 330                 335     

Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp Leu Val Asn Ala 
            340                 345                 350         

Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr Thr Asp Lys Asn 
        355                 360                 365             

Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu Tyr Lys Phe Val 
    370                 375                 380                 

Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Glu Ile Thr Thr 
385                 390                 395                 400 

Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu Asn Pro Lys Pro 
                405                 410                 415     

Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly Lys Lys Phe Val 
            420                 425                 430         

Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala Glu Phe Val Ile 
        435                 440                 445             

Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg Lys Ala Asp Lys 
    450                 455                 460                 

Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr Lys Asp Ala Leu 
465                 470                 475                 480 

Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala Gln Gln Gln Thr 
                485                 490                 495     

Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala Ala Tyr Asn Ala 
            500                 505                 510         

Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val Ala Asp Lys Asp 
        515                 520                 525             

Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln Gly Arg Phe Glu 
    530                 535                 540                 

Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu Glu Thr Lys Gln 
545                 550                 555                 560 

Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys Phe Glu Val Thr 
                565                 570                 575     

Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu Tyr Thr Ala Gly 
            580                 585                 590         

Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Gly 
        595                 600                 605             

Ser Gly Ser Gly Gly Gly Gly Ala Glu Gln Lys Thr Lys Thr Leu Thr 
    610                 615                 620                 

Val His Lys Leu Leu Met Thr Asp Gln Glu Leu Asp Ala Trp Asn Ser 
625                 630                 635                 640 

Asp Ala Ile Thr Thr Ala Gly Tyr Asp Gly Ser Gln Asn Phe Glu Gln 
                645                 650                 655     

Phe Lys Gln Leu Gln Gly Val Pro Gln Gly Val Thr Glu Ile Ser Gly 
            660                 665                 670         

Val Ala Phe Glu Leu Gln Ser Tyr Thr Gly Pro Gln Gly Lys Glu Gln 
        675                 680                 685             

Glu Asn Leu Thr Asn Asp Ala Val Trp Thr Ala Val Asn Lys Gly Val 
    690                 695                 700                 

Thr Thr Glu Thr Gly Val Lys Phe Asp Thr Glu Val Leu Gln Gly Thr 
705                 710                 715                 720 

Tyr Arg Leu Val Glu Val Arg Lys Glu Ser Thr Tyr Val Gly Pro Asn 
                725                 730                 735     

Gly Lys Val Leu Thr Gly Met Lys Ala Val Pro Ala Leu Ile Ile Leu 
            740                 745                 750         

Pro Leu Val Asn Gln Asn Gly Val Val Glu Asn Ala His Val Tyr Pro 
        755                 760                 765             

Lys Asn Ser Glu Asp Lys Pro Thr Ala Thr Lys Thr Phe Asp Thr Ala 
    770                 775                 780                 

Ala Gly Phe Val Asp Pro Gly Glu Lys Gly Leu Ala Ile Gly Thr Lys 
785                 790                 795                 800 

Val Pro Tyr Ile Val Thr Thr Thr Ile Pro Lys Asn Ser Thr Leu Ala 
                805                 810                 815     

Thr Ala Phe Trp Ser Asp Glu Met Thr Glu Gly Leu Asp Tyr Asn Gly 
            820                 825                 830         

Asp Val Val Val Asn Tyr Asn Gly Gln Pro Leu Asp Asn Ser His Tyr 
        835                 840                 845             

Thr Leu Glu Ala Gly His Asn Gly Phe Ile Leu Lys Leu Asn Glu Lys 
    850                 855                 860                 

Gly Leu Glu Ala Ile Asn Gly Lys Asp Ala Glu Ala Thr Ile Thr Leu 
865                 870                 875                 880 

Lys Tyr Thr Ala Thr Leu Asn Ala Leu Ala Val Ala Asp Val Pro Glu 
                885                 890                 895     

Ala Asn Asp Val Thr Phe His Tyr Gly Asn Asn Pro Gly His Gly Asn 
            900                 905                 910         

Thr Pro Lys Pro Asn Lys Pro Lys Asn Gly Glu Leu Thr Ile Thr Lys 
        915                 920                 925             

Thr Trp Ala Asp Ala Lys Asp Ala Pro Ile Ala Gly Val Glu Val Thr 
    930                 935                 940                 

Phe Asp Leu Val Asn Ala Gln Thr Gly Glu Val Val Lys Val Pro Gly 
945                 950                 955                 960 

His Glu Thr Gly Ile Val Leu Asn Gln Thr Asn Asn Trp Thr Phe Thr 
                965                 970                 975     

Ala Thr Gly Leu Asp Asn Asn Thr Glu Tyr Lys Phe Val Glu Arg Thr 
            980                 985                 990         

Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Thr Ile Thr Glu Thr Gly Lys 
        995                 1000                1005            

Ile Ala Val Lys Asn Trp Lys Asp Glu Asn Pro Glu Pro Ile Asn Pro 
    1010                1015                1020                

Glu Glu Pro Arg Val Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp 
1025                1030                1035                1040

Gln Lys Asp Glu Arg Leu Lys Glu Ala Gln Phe Val Val Lys Asn Glu 
                1045                1050                1055    

Gln Gly Lys Tyr Leu Ala Leu Lys Ser Ala Ala Gln Gln Ala Val Asn 
            1060                1065                1070        

Glu Lys Ala Ala Ala Glu Ala Lys Gln Ala Leu Asp Ala Ala Ile Ala 
        1075                1080                1085            

Ala Tyr Thr Asn Ala Ala Asp Lys Asn Ala Ala Gln Ala Val Val Asp 
    1090                1095                1100                

Ala Ala Gln Lys Thr Tyr Asn Asp Asn Tyr Arg Ala Ala Arg Phe Gly 
1105                1110                1115                1120

Tyr Val Glu Val Glu Arg Lys Glu Asp Ala Leu Val Leu Thr Ser Asn 
                1125                1130                1135    

Thr Asp Gly Gln Phe Gln Ile Ser Gly Leu Ala Ala Gly Ser Tyr Thr 
            1140                1145                1150        

Leu Glu Glu Thr Lys Ala Pro Glu Gly Phe Ala Lys Leu Gly Asp Val 
        1155                1160                1165            

Lys Phe Glu Val Gly Ala Gly Ser Trp Asn Gln Gly Asp Phe Asn Tyr 
    1170                1175                1180                

Leu Lys Asp Val Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys 
1185                1190                1195                1200

Ile Thr Leu Gly Gly Ser Gly Gly Gly Gly Ala Ala Thr Val Phe Ala 
                1205                1210                1215    

Ala Asp Asn Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr 
            1220                1225                1230        

Ile His Lys Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr 
        1235                1240                1245            

Asn Gly Pro Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu 
    1250                1255                1260                

Thr Gly Val Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln 
1265                1270                1275                1280

Lys Tyr Asn Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp 
                1285                1290                1295    

Ser Lys Trp Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu 
            1300                1305                1310        

Lys Ile Glu Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp 
        1315                1320                1325            

Arg Thr Lys Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly 
    1330                1335                1340                

Ser Lys Ala Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn 
1345                1350                1355                1360

Gly Thr Val Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys 
                1365                1370                1375    

Pro Val Val Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln 
            1380                1385                1390        

Asn Gly Leu Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr 
        1395                1400                1405            

Ile Pro Ser Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met 
    1410                1415                1420                

Thr Glu Gly Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn 
1425                1430                1435                1440

Val Ala Met Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Asn Asn Gly 
                1445                1450                1455    

Phe Asn Leu Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys 
            1460                1465                1470        

Asp Ala Asp Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser 
        1475                1480                1485            

Leu Ala Val Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr 
    1490                1495                1500                

Gly Asn His Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn 
1505                1510                1515                1520

Asn Gly Gln Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro 
                1525                1530                1535    

Glu Gly Val Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu 
            1540                1545                1550        

Lys Val Gly Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr 
        1555                1560                1565            

Trp Ser Gly Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr 
    1570                1575                1580                

Asn Gly Tyr Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly 
1585                1590                1595                1600

Val Lys Asn Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu 
                1605                1610                1615    

Pro Arg Val Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys 
            1620                1625                1630        

Asp Thr Arg Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser 
        1635                1640                1645            

Asn Lys Tyr Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu 
    1650                1655                1660                

Lys Ala Ala Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala 
1665                1670                1675                1680

Tyr Thr Asn Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln 
                1685                1690                1695    

Ala Gln Gln Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr 
            1700                1705                1710        

Val Glu Val Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr 
        1715                1720                1725            

Asp Gly Gln Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu 
    1730                1735                1740                

Glu Glu Ile Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu 
1745                1750                1755                1760

Phe Val Val Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu 
                1765                1770                1775    

Lys Asp Val Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile 
            1780                1785                1790        

Thr Leu Gly His His His His His His 
        1795                1800    

<210>   14
<211>   5403
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence encoding SEQ ID NO: 13

<400>   14
atggctagcg ctgcaacagt ttttgcggct gggacgacaa caacatctgt taccgttcat   60
aaactattgg caacagatgg ggatatggat aaaattgcaa atgagttaga aacaggtaac   120
tatgctggta ataaagtggg tgttctacct gcaaatgcaa aagaaattgc cggtgttatg   180
ttcgtttgga caaatactaa taatgaaatt attgatgaaa atggccaaac tctaggagtg   240
aatattgatc cacaaacatt taaactctca ggggcaatgc cggcaactgc aatgaaaaaa   300
ttaacagaag ctgaaggagc taaatttaac acggcaaatt taccagctgc taagtataaa   360
atttatgaaa ttcacagttt atcaacttat gtcggtgaag atggagcaac cttaacaggt   420
tctaaagcag ttccaattga aattgaatta ccattgaacg atgttgtgga tgcgcatgtg   480
tatccaaaaa atacagaagc aaagccaaaa attgataaag atttcaaagg taaagcaaat   540
ccagatacac cacgtgtaga taaagataca cctgtgaacc accaagttgg agatgttgta   600
gagtacgaaa ttgttacaaa aattccagca cttgctaatt atgcaacagc aaactggagc   660
gatagaatga ctgaaggttt ggcattcaac aaaggtacag tgaaagtaac tgttgatgat   720
gttgcacttg aagcaggtga ttatgctcta acagaagtag caactggttt tgatttgaaa   780
ttaacagatg ctggtttagc taaagtgaat gaccaaaacg ctgaaaaaac tgtgaaaatc   840
acttattcgg caacattgaa tgacaaagca attgtagaag taccagaatc taatgatgta   900
acatttaact atggtaataa tccagatcac gggaatactc caaagccgaa taagccaaat   960
gaaaacggcg atttgacatt gaccaagaca tgggttgatg ctacaggtgc accaattccg   1020
gctggagctg aagcaacgtt cgatttggtt aatgctcaga ctggtaaagt tgtacaaact   1080
gtaactttga caacagacaa aaatacagtt actgttaacg gattggataa aaatacagaa   1140
tataaattcg ttgaacgtag tataaaaggg tattcagcag attatcaaga aatcactaca   1200
gctggagaaa ttgctgtcaa gaactggaaa gacgaaaatc caaaaccact tgatccaaca   1260
gagccaaaag ttgttacata tggtaaaaag tttgtcaaag ttaatgataa agataatcgt   1320
ttagctgggg cagaatttgt aattgcaaat gctgataatg ctggtcaata tttagcacgt   1380
aaagcagata aagtgagtca agaagagaag cagttggttg ttacaacaaa ggatgcttta   1440
gatagagcag ttgctgctta taacgctctt actgcacaac aacaaactca gcaagaaaaa   1500
gagaaagttg acaaagctca agctgcttat aatgctgctg tgattgctgc caacaatgca   1560
tttgaatggg tggcagataa ggacaatgaa aatgttgtga aattagtttc tgatgcacaa   1620
ggtcgctttg aaattacagg ccttcttgca ggtacatatt acttagaaga aacaaaacag   1680
cctgctggtt atgcattact aactagccgt cagaaatttg aagtcactgc aacttcttat   1740
tcagcgactg gacaaggcat tgagtatact gctggttcag gtaaagatga cgctacaaaa   1800
gtagtcaaca aaaaaatcac tggatccggc agcggtggcg gtggcgcgga acaaaaaact   1860
aagacactta cagttcataa attattgatg acagatcaag agcttgacgc ttggaattct   1920
gatgcgatta ctactgcagg ttatgacggt tcgcaaaatt ttgaacagtt caaacaactt   1980
caaggtgttc cacaaggagt aaccgaaatc tctggtgttg cattcgagtt acagagttat   2040
acgggtcctc aaggaaaaga acaagaaaat ttaacgaatg atgcggtttg gactgcggtt   2100
aataaaggtg tgacgactga aacgggtgtt aaatttgata ctgaagtttt acaagggaca   2160
tatcgtcttg tcgaagtacg taaagaatcg acttatgtcg gtccaaatgg taaagtttta   2220
acaggtatga aagctgttcc tgctttaatt attctgccgc ttgtaaacca aaatggtgtt   2280
gtagaaaatg cacatgtcta tccaaagaat tctgaagaca aacctacagc aacgaaaaca   2340
tttgatactg cagcaggttt cgtagatcca ggtgaaaaag gtttagcaat tggcactaag   2400
gtaccgtata ttgttacaac aactattccg aaaaactcaa ctcttgcaac agctttctgg   2460
tcagatgaaa tgacagaagg tctagattat aatggtgatg tagttgttaa ttataatggt   2520
caaccgcttg ataattctca ttacacatta gaagcaggtc ataatggctt tatcttgaag   2580
ttaaatgaaa aaggtctgga agcaatcaac ggtaaagatg cagaagcaac aattacgttg   2640
aagtatactg caactttaaa tgctcttgct gttgctgatg tgccagaagc gaatgatgta   2700
acattccatt atggaaacaa cccaggtcat ggtaacactc caaaaccaaa caaacctaaa   2760
aacggtgaac ttacaattac taaaacatgg gctgatgcta aagatgctcc tatagcaggt   2820
gtagaagtaa cttttgattt ggtaaatgct cagacaggtg aggtcgttaa agtacctgga   2880
catgaaacag gtattgtatt gaatcaaaca aataattgga catttactgc tacaggtctt   2940
gataataata cagaatataa atttgttgaa cggacaatta agggatattc tgcagattac   3000
caaacaatta ctgaaacagg aaaaattgct gttaaaaact ggaaagatga aaatccagaa   3060
ccaataaatc ctgaagagcc acgtgtaaaa acatatggta aaaaattcgt taaggttgac   3120
caaaaagacg aacgcttaaa agaagcacaa ttcgttgtga agaatgagca agggaaatat   3180
cttgcactca aatctgcagc acaacaagct gtaaatgaga aagctgccgc agaagcgaaa   3240
caagcgctag atgcagcgat agcagcctat acaaatgctg cagataaaaa tgcagcacaa   3300
gctgtagtag atgctgcgca aaaaacatat aatgacaatt acagagcagc tagatttggc   3360
tatgtagaag tagagagaaa agaagatgcg ttagttctta cttctaacac tgatggtcaa   3420
ttccaaattt caggtcttgc tgctggaagc tacacgttgg aagaaacaaa agctccagaa   3480
ggctttgcaa aacttggaga tgtgaagttt gaggttggag caggttcttg gaatcaaggt   3540
gatttcaatt atttaaaaga tgttcagaag aacgacgcta caaaagtagt caacaaaaaa   3600
atcacgctcg agggcagcgg tggcggtggc gctgcaacag tttttgcggc ggacaatgtt   3660
agtacagcac cagatgctgt tactaaaact ttaacaatcc ataagttact gctctcagaa   3720
gatgatttaa agacttggga tacaaacggt cctaaaggat atgatggaac tcaatctagt   3780
ttaaaagatt taactggagt tgtagctgag gaaattccaa atgtatactt tgaattacaa   3840
aagtataatt tgactgatgg taaggaaaaa gaaaatctta aagatgatag taaatggaca   3900
acagttcatg gtggtttgac aactaaagat ggacttaaaa ttgaaaccag tactcttaaa   3960
ggtgtgtatc gtattcgtga ggatagaaca aagactacct atgttggtcc taatgggcaa   4020
gtattaacag gttcaaaagc cgtacctgct cttgtaactc ttccacttgt taacaataat   4080
ggtacagtaa ttgatgcaca tgttttccct aaaaattcat ataataaacc agttgtagat   4140
aaaagaattg ctgatacttt gaattataac gatcaaaatg gtctgtctat cggtactaaa   4200
atcccatatg ttgttaatac aacaattcca agtaatgcaa catttgcaac ttcattttgg   4260
tcagatgaaa tgacagaagg tctaacttat aatgaagatg taacaattac tttgaataat   4320
gtagctatgg atcaagctga ttatgaagtc actaaaggaa ataatggctt taacttaaaa   4380
ttaacagaag caggtttagc taaaattaat ggtaaggatg cagaccaaaa aatccaaatt   4440
acttactcag ctactttgaa ctcacttgct gttgcagaca ttcctgaaag taacgatatt   4500
acatatcatt acggaaatca tcaagatcat gggaatactc caaaaccaac taaacctaat   4560
aatggtcaaa ttacagtaac taagacatgg gacagtcaac ctgctcctga gggggtgaaa   4620
gcgactgttc aacttgtaaa tgccaagact ggtgagaaag tcggtgctcc tgtagaactt   4680
tcagaaaata attggacata tacttggagt ggtctagata attctattga atacaaagtt   4740
gaagaagaat ataatggata ctcagctgaa tacacagtag agagcaaagg gaagttgggg   4800
gtaaaaaact ggaaagataa taacccagct ccaatcaatc ctgaagaacc acgtgtaaaa   4860
acatacggta aaaagtttgt caaagtagac caaaaagata ctcgtctaga aaatgcgcag   4920
ttcgttgtta aaaaagcaga tagcaataaa tatattgcct ttaagtcaac tgcacaacaa   4980
gctgcagatg aaaaagcagc agcaactgca aaacaaaaat tggatgcagc ggtagcagct   5040
tacacaaatg ctgcagataa gcaagccgct caagctctag tagatcaagc acagcaagaa   5100
tacaatgtag cttacaaaga agccaaattt ggttatgttg aagtagctgg aaaagatgaa   5160
gcaatggttc ttacttctaa tacggatggt caattccaaa tttcaggtct tgctgctggt   5220
acttataaat tagaagaaat taaagctcca gaaggttttg cgaaaattga tgatgtagaa   5280
tttgttgttg gagcaggttc ttggaatcaa ggtgagttta attacttaaa agatgttcaa   5340
aagaatgacg ctacaaaagt agtcaacaaa aaaatcactc tcgagcacca ccaccaccac   5400
cac                                                                 5403

<210>   15
<211>   1801
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   RrgB III-II-I

<400>   15
Met Ala Ser Ala Glu Gln Lys Thr Lys Thr Leu Thr Val His Lys Leu 
1               5                   10                  15      

Leu Met Thr Asp Gln Glu Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr 
            20                  25                  30          

Thr Ala Gly Tyr Asp Gly Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu 
        35                  40                  45              

Gln Gly Val Pro Gln Gly Val Thr Glu Ile Ser Gly Val Ala Phe Glu 
    50                  55                  60                  

Leu Gln Ser Tyr Thr Gly Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr 
65                  70                  75                  80  

Asn Asp Ala Val Trp Thr Ala Val Asn Lys Gly Val Thr Thr Glu Thr 
                85                  90                  95      

Gly Val Lys Phe Asp Thr Glu Val Leu Gln Gly Thr Tyr Arg Leu Val 
            100                 105                 110         

Glu Val Arg Lys Glu Ser Thr Tyr Val Gly Pro Asn Gly Lys Val Leu 
        115                 120                 125             

Thr Gly Met Lys Ala Val Pro Ala Leu Ile Ile Leu Pro Leu Val Asn 
    130                 135                 140                 

Gln Asn Gly Val Val Glu Asn Ala His Val Tyr Pro Lys Asn Ser Glu 
145                 150                 155                 160 

Asp Lys Pro Thr Ala Thr Lys Thr Phe Asp Thr Ala Ala Gly Phe Val 
                165                 170                 175     

Asp Pro Gly Glu Lys Gly Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile 
            180                 185                 190         

Val Thr Thr Thr Ile Pro Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp 
        195                 200                 205             

Ser Asp Glu Met Thr Glu Gly Leu Asp Tyr Asn Gly Asp Val Val Val 
    210                 215                 220                 

Asn Tyr Asn Gly Gln Pro Leu Asp Asn Ser His Tyr Thr Leu Glu Ala 
225                 230                 235                 240 

Gly His Asn Gly Phe Ile Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala 
                245                 250                 255     

Ile Asn Gly Lys Asp Ala Glu Ala Thr Ile Thr Leu Lys Tyr Thr Ala 
            260                 265                 270         

Thr Leu Asn Ala Leu Ala Val Ala Asp Val Pro Glu Ala Asn Asp Val 
        275                 280                 285             

Thr Phe His Tyr Gly Asn Asn Pro Gly His Gly Asn Thr Pro Lys Pro 
    290                 295                 300                 

Asn Lys Pro Lys Asn Gly Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp 
305                 310                 315                 320 

Ala Lys Asp Ala Pro Ile Ala Gly Val Glu Val Thr Phe Asp Leu Val 
                325                 330                 335     

Asn Ala Gln Thr Gly Glu Val Val Lys Val Pro Gly His Glu Thr Gly 
            340                 345                 350         

Ile Val Leu Asn Gln Thr Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu 
        355                 360                 365             

Asp Asn Asn Thr Glu Tyr Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr 
    370                 375                 380                 

Ser Ala Asp Tyr Gln Thr Ile Thr Glu Thr Gly Lys Ile Ala Val Lys 
385                 390                 395                 400 

Asn Trp Lys Asp Glu Asn Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg 
                405                 410                 415     

Val Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Glu 
            420                 425                 430         

Arg Leu Lys Glu Ala Gln Phe Val Val Lys Asn Glu Gln Gly Lys Tyr 
        435                 440                 445             

Leu Ala Leu Lys Ser Ala Ala Gln Gln Ala Val Asn Glu Lys Ala Ala 
    450                 455                 460                 

Ala Glu Ala Lys Gln Ala Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn 
465                 470                 475                 480 

Ala Ala Asp Lys Asn Ala Ala Gln Ala Val Val Asp Ala Ala Gln Lys 
                485                 490                 495     

Thr Tyr Asn Asp Asn Tyr Arg Ala Ala Arg Phe Gly Tyr Val Glu Val 
            500                 505                 510         

Glu Arg Lys Glu Asp Ala Leu Val Leu Thr Ser Asn Thr Asp Gly Gln 
        515                 520                 525             

Phe Gln Ile Ser Gly Leu Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr 
    530                 535                 540                 

Lys Ala Pro Glu Gly Phe Ala Lys Leu Gly Asp Val Lys Phe Glu Val 
545                 550                 555                 560 

Gly Ala Gly Ser Trp Asn Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val 
                565                 570                 575     

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Gly Ser 
            580                 585                 590         

Gly Ser Gly Gly Gly Gly Ala Ala Thr Val Phe Ala Ala Asp Asn Val 
        595                 600                 605             

Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys Leu 
    610                 615                 620                 

Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro Lys 
625                 630                 635                 640 

Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val Val 
                645                 650                 655     

Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn Leu 
            660                 665                 670         

Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp Thr 
        675                 680                 685             

Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu Thr 
    690                 695                 700                 

Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys Thr 
705                 710                 715                 720 

Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala Val 
                725                 730                 735     

Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val Ile 
            740                 745                 750         

Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val Asp 
        755                 760                 765             

Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu Ser 
    770                 775                 780                 

Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser Asn 
785                 790                 795                 800 

Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly Leu 
                805                 810                 815     

Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met Asp 
            820                 825                 830         

Gln Ala Asp Tyr Glu Val Thr Lys Gly Asn Asn Gly Phe Asn Leu Lys 
        835                 840                 845             

Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp Gln 
    850                 855                 860                 

Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val Ala 
865                 870                 875                 880 

Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His Gln 
                885                 890                 895     

Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln Ile 
            900                 905                 910         

Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val Lys 
        915                 920                 925             

Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly Ala 
    930                 935                 940                 

Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly Leu 
945                 950                 955                 960 

Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr Ser 
                965                 970                 975     

Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn Trp 
            980                 985                 990         

Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val Lys 
        995                 1000                1005            

Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg Leu 
    1010                1015                1020                

Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr Ile 
1025                1030                1035                1040

Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala Ala 
                1045                1050                1055    

Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn Ala 
            1060                1065                1070        

Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln Glu 
        1075                1080                1085            

Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val Ala 
    1090                1095                1100                

Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln Phe 
1105                1110                1115                1120

Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile Lys 
                1125                1130                1135    

Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val Gly 
            1140                1145                1150        

Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val Gln 
        1155                1160                1165            

Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Leu Gly Gly 
    1170                1175                1180                

Ser Gly Gly Gly Gly Ala Ala Thr Val Phe Ala Ala Gly Thr Thr Thr 
1185                1190                1195                1200

Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp Met Asp 
                1205                1210                1215    

Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn Lys Val 
            1220                1225                1230        

Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met Phe Val 
        1235                1240                1245            

Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln Thr Leu 
    1250                1255                1260                

Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala Met Pro 
1265                1270                1275                1280

Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys Phe Asn 
                1285                1290                1295    

Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile His Ser 
            1300                1305                1310        

Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly Ser Lys 
        1315                1320                1325            

Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val Asp Ala 
    1330                1335                1340                

His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp Lys Asp 
1345                1350                1355                1360

Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys Asp Thr 
                1365                1370                1375    

Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile Val Thr 
            1380                1385                1390        

Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser Asp Arg 
        1395                1400                1405            

Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val Thr Val 
    1410                1415                1420                

Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu Val Ala 
1425                1430                1435                1440

Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys Val Asn 
                1445                1450                1455    

Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala Thr Leu 
            1460                1465                1470        

Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val Thr Phe 
        1475                1480                1485            

Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro Asn Lys 
    1490                1495                1500                

Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val Asp Ala 
1505                1510                1515                1520

Thr Gly Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp Leu Val 
                1525                1530                1535    

Asn Ala Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr Thr Asp 
            1540                1545                1550        

Lys Asn Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu Tyr Lys 
        1555                1560                1565            

Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Glu Ile 
    1570                1575                1580                

Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu Asn Pro 
1585                1590                1595                1600

Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly Lys Lys 
                1605                1610                1615    

Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala Glu Phe 
            1620                1625                1630        

Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg Lys Ala 
        1635                1640                1645            

Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr Lys Asp 
    1650                1655                1660                

Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala Gln Gln 
1665                1670                1675                1680

Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala Ala Tyr 
                1685                1690                1695    

Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val Ala Asp 
            1700                1705                1710        

Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln Gly Arg 
        1715                1720                1725            

Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu Glu Thr 
    1730                1735                1740                

Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys Phe Glu 
1745                1750                1755                1760

Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu Tyr Thr 
                1765                1770                1775    

Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys Lys Ile 
            1780                1785                1790        

Thr Leu Gly His His His His His His 
        1795                1800    

<210>   16
<211>   5403
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence encoding SEQ ID NO: 15

<400>   16
atggctagcg cggaacaaaa aactaagaca cttacagttc ataaattatt gatgacagat   60
caagagcttg acgcttggaa ttctgatgcg attactactg caggttatga cggttcgcaa   120
aattttgaac agttcaaaca acttcaaggt gttccacaag gagtaaccga aatctctggt   180
gttgcattcg agttacagag ttatacgggt cctcaaggaa aagaacaaga aaatttaacg   240
aatgatgcgg tttggactgc ggttaataaa ggtgtgacga ctgaaacggg tgttaaattt   300
gatactgaag ttttacaagg gacatatcgt cttgtcgaag tacgtaaaga atcgacttat   360
gtcggtccaa atggtaaagt tttaacaggt atgaaagctg ttcctgcttt aattattctg   420
ccgcttgtaa accaaaatgg tgttgtagaa aatgcacatg tctatccaaa gaattctgaa   480
gacaaaccta cagcaacgaa aacatttgat actgcagcag gtttcgtaga tccaggtgaa   540
aaaggtttag caattggcac taaggtaccg tatattgtta caacaactat tccgaaaaac   600
tcaactcttg caacagcttt ctggtcagat gaaatgacag aaggtctaga ttataatggt   660
gatgtagttg ttaattataa tggtcaaccg cttgataatt ctcattacac attagaagca   720
ggtcataatg gctttatctt gaagttaaat gaaaaaggtc tggaagcaat caacggtaaa   780
gatgcagaag caacaattac gttgaagtat actgcaactt taaatgctct tgctgttgct   840
gatgtgccag aagcgaatga tgtaacattc cattatggaa acaacccagg tcatggtaac   900
actccaaaac caaacaaacc taaaaacggt gaacttacaa ttactaaaac atgggctgat   960
gctaaagatg ctcctatagc aggtgtagaa gtaacttttg atttggtaaa tgctcagaca   1020
ggtgaggtcg ttaaagtacc tggacatgaa acaggtattg tattgaatca aacaaataat   1080
tggacattta ctgctacagg tcttgataat aatacagaat ataaatttgt tgaacggaca   1140
attaagggat attctgcaga ttaccaaaca attactgaaa caggaaaaat tgctgttaaa   1200
aactggaaag atgaaaatcc agaaccaata aatcctgaag agccacgtgt aaaaacatat   1260
ggtaaaaaat tcgttaaggt tgaccaaaaa gacgaacgct taaaagaagc acaattcgtt   1320
gtgaagaatg agcaagggaa atatcttgca ctcaaatctg cagcacaaca agctgtaaat   1380
gagaaagctg ccgcagaagc gaaacaagcg ctagatgcag cgatagcagc ctatacaaat   1440
gctgcagata aaaatgcagc acaagctgta gtagatgctg cgcaaaaaac atataatgac   1500
aattacagag cagctagatt tggctatgta gaagtagaga gaaaagaaga tgcgttagtt   1560
cttacttcta acactgatgg tcaattccaa atttcaggtc ttgctgctgg aagctacacg   1620
ttggaagaaa caaaagctcc agaaggcttt gcaaaacttg gagatgtgaa gtttgaggtt   1680
ggagcaggtt cttggaatca aggtgatttc aattatttaa aagatgttca gaagaacgac   1740
gctacaaaag tagtcaacaa aaaaatcacg ggatccggca gcggtggcgg tggcgctgca   1800
acagtttttg cggcggacaa tgttagtaca gcaccagatg ctgttactaa aactttaaca   1860
atccataagt tactgctctc agaagatgat ttaaagactt gggatacaaa cggtcctaaa   1920
ggatatgatg gaactcaatc tagtttaaaa gatttaactg gagttgtagc tgaggaaatt   1980
ccaaatgtat actttgaatt acaaaagtat aatttgactg atggtaagga aaaagaaaat   2040
cttaaagatg atagtaaatg gacaacagtt catggtggtt tgacaactaa agatggactt   2100
aaaattgaaa ccagtactct taaaggtgtg tatcgtattc gtgaggatag aacaaagact   2160
acctatgttg gtcctaatgg gcaagtatta acaggttcaa aagccgtacc tgctcttgta   2220
actcttccac ttgttaacaa taatggtaca gtaattgatg cacatgtttt ccctaaaaat   2280
tcatataata aaccagttgt agataaaaga attgctgata ctttgaatta taacgatcaa   2340
aatggtctgt ctatcggtac taaaatccca tatgttgtta atacaacaat tccaagtaat   2400
gcaacatttg caacttcatt ttggtcagat gaaatgacag aaggtctaac ttataatgaa   2460
gatgtaacaa ttactttgaa taatgtagct atggatcaag ctgattatga agtcactaaa   2520
ggaaataatg gctttaactt aaaattaaca gaagcaggtt tagctaaaat taatggtaag   2580
gatgcagacc aaaaaatcca aattacttac tcagctactt tgaactcact tgctgttgca   2640
gacattcctg aaagtaacga tattacatat cattacggaa atcatcaaga tcatgggaat   2700
actccaaaac caactaaacc taataatggt caaattacag taactaagac atgggacagt   2760
caacctgctc ctgagggggt gaaagcgact gttcaacttg taaatgccaa gactggtgag   2820
aaagtcggtg ctcctgtaga actttcagaa aataattgga catatacttg gagtggtcta   2880
gataattcta ttgaatacaa agttgaagaa gaatataatg gatactcagc tgaatacaca   2940
gtagagagca aagggaagtt gggggtaaaa aactggaaag ataataaccc agctccaatc   3000
aatcctgaag aaccacgtgt aaaaacatac ggtaaaaagt ttgtcaaagt agaccaaaaa   3060
gatactcgtc tagaaaatgc gcagttcgtt gttaaaaaag cagatagcaa taaatatatt   3120
gcctttaagt caactgcaca acaagctgca gatgaaaaag cagcagcaac tgcaaaacaa   3180
aaattggatg cagcggtagc agcttacaca aatgctgcag ataagcaagc cgctcaagct   3240
ctagtagatc aagcacagca agaatacaat gtagcttaca aagaagccaa atttggttat   3300
gttgaagtag ctggaaaaga tgaagcaatg gttcttactt ctaatacgga tggtcaattc   3360
caaatttcag gtcttgctgc tggtacttat aaattagaag aaattaaagc tccagaaggt   3420
tttgcgaaaa ttgatgatgt agaatttgtt gttggagcag gttcttggaa tcaaggtgag   3480
tttaattact taaaagatgt tcaaaagaat gacgctacaa aagtagtcaa caaaaaaatc   3540
actctcgagg gcagcggtgg cggtggcgct gcaacagttt ttgcggctgg gacgacaaca   3600
acatctgtta ccgttcataa actattggca acagatgggg atatggataa aattgcaaat   3660
gagttagaaa caggtaacta tgctggtaat aaagtgggtg ttctacctgc aaatgcaaaa   3720
gaaattgccg gtgttatgtt cgtttggaca aatactaata atgaaattat tgatgaaaat   3780
ggccaaactc taggagtgaa tattgatcca caaacattta aactctcagg ggcaatgccg   3840
gcaactgcaa tgaaaaaatt aacagaagct gaaggagcta aatttaacac ggcaaattta   3900
ccagctgcta agtataaaat ttatgaaatt cacagtttat caacttatgt cggtgaagat   3960
ggagcaacct taacaggttc taaagcagtt ccaattgaaa ttgaattacc attgaacgat   4020
gttgtggatg cgcatgtgta tccaaaaaat acagaagcaa agccaaaaat tgataaagat   4080
ttcaaaggta aagcaaatcc agatacacca cgtgtagata aagatacacc tgtgaaccac   4140
caagttggag atgttgtaga gtacgaaatt gttacaaaaa ttccagcact tgctaattat   4200
gcaacagcaa actggagcga tagaatgact gaaggtttgg cattcaacaa aggtacagtg   4260
aaagtaactg ttgatgatgt tgcacttgaa gcaggtgatt atgctctaac agaagtagca   4320
actggttttg atttgaaatt aacagatgct ggtttagcta aagtgaatga ccaaaacgct   4380
gaaaaaactg tgaaaatcac ttattcggca acattgaatg acaaagcaat tgtagaagta   4440
ccagaatcta atgatgtaac atttaactat ggtaataatc cagatcacgg gaatactcca   4500
aagccgaata agccaaatga aaacggcgat ttgacattga ccaagacatg ggttgatgct   4560
acaggtgcac caattccggc tggagctgaa gcaacgttcg atttggttaa tgctcagact   4620
ggtaaagttg tacaaactgt aactttgaca acagacaaaa atacagttac tgttaacgga   4680
ttggataaaa atacagaata taaattcgtt gaacgtagta taaaagggta ttcagcagat   4740
tatcaagaaa tcactacagc tggagaaatt gctgtcaaga actggaaaga cgaaaatcca   4800
aaaccacttg atccaacaga gccaaaagtt gttacatatg gtaaaaagtt tgtcaaagtt   4860
aatgataaag ataatcgttt agctggggca gaatttgtaa ttgcaaatgc tgataatgct   4920
ggtcaatatt tagcacgtaa agcagataaa gtgagtcaag aagagaagca gttggttgtt   4980
acaacaaagg atgctttaga tagagcagtt gctgcttata acgctcttac tgcacaacaa   5040
caaactcagc aagaaaaaga gaaagttgac aaagctcaag ctgcttataa tgctgctgtg   5100
attgctgcca acaatgcatt tgaatgggtg gcagataagg acaatgaaaa tgttgtgaaa   5160
ttagtttctg atgcacaagg tcgctttgaa attacaggcc ttcttgcagg tacatattac   5220
ttagaagaaa caaaacagcc tgctggttat gcattactaa ctagccgtca gaaatttgaa   5280
gtcactgcaa cttcttattc agcgactgga caaggcattg agtatactgc tggttcaggt   5340
aaagatgacg ctacaaaagt agtcaacaaa aaaatcactc tcgagcacca ccaccaccac   5400
cac                                                                 5403

<210>   17
<211>   1801
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   RrgB III-I-II

<400>   17
Met Ala Ser Ala Glu Gln Lys Thr Lys Thr Leu Thr Val His Lys Leu 
1               5                   10                  15      

Leu Met Thr Asp Gln Glu Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr 
            20                  25                  30          

Thr Ala Gly Tyr Asp Gly Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu 
        35                  40                  45              

Gln Gly Val Pro Gln Gly Val Thr Glu Ile Ser Gly Val Ala Phe Glu 
    50                  55                  60                  

Leu Gln Ser Tyr Thr Gly Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr 
65                  70                  75                  80  

Asn Asp Ala Val Trp Thr Ala Val Asn Lys Gly Val Thr Thr Glu Thr 
                85                  90                  95      

Gly Val Lys Phe Asp Thr Glu Val Leu Gln Gly Thr Tyr Arg Leu Val 
            100                 105                 110         

Glu Val Arg Lys Glu Ser Thr Tyr Val Gly Pro Asn Gly Lys Val Leu 
        115                 120                 125             

Thr Gly Met Lys Ala Val Pro Ala Leu Ile Ile Leu Pro Leu Val Asn 
    130                 135                 140                 

Gln Asn Gly Val Val Glu Asn Ala His Val Tyr Pro Lys Asn Ser Glu 
145                 150                 155                 160 

Asp Lys Pro Thr Ala Thr Lys Thr Phe Asp Thr Ala Ala Gly Phe Val 
                165                 170                 175     

Asp Pro Gly Glu Lys Gly Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile 
            180                 185                 190         

Val Thr Thr Thr Ile Pro Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp 
        195                 200                 205             

Ser Asp Glu Met Thr Glu Gly Leu Asp Tyr Asn Gly Asp Val Val Val 
    210                 215                 220                 

Asn Tyr Asn Gly Gln Pro Leu Asp Asn Ser His Tyr Thr Leu Glu Ala 
225                 230                 235                 240 

Gly His Asn Gly Phe Ile Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala 
                245                 250                 255     

Ile Asn Gly Lys Asp Ala Glu Ala Thr Ile Thr Leu Lys Tyr Thr Ala 
            260                 265                 270         

Thr Leu Asn Ala Leu Ala Val Ala Asp Val Pro Glu Ala Asn Asp Val 
        275                 280                 285             

Thr Phe His Tyr Gly Asn Asn Pro Gly His Gly Asn Thr Pro Lys Pro 
    290                 295                 300                 

Asn Lys Pro Lys Asn Gly Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp 
305                 310                 315                 320 

Ala Lys Asp Ala Pro Ile Ala Gly Val Glu Val Thr Phe Asp Leu Val 
                325                 330                 335     

Asn Ala Gln Thr Gly Glu Val Val Lys Val Pro Gly His Glu Thr Gly 
            340                 345                 350         

Ile Val Leu Asn Gln Thr Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu 
        355                 360                 365             

Asp Asn Asn Thr Glu Tyr Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr 
    370                 375                 380                 

Ser Ala Asp Tyr Gln Thr Ile Thr Glu Thr Gly Lys Ile Ala Val Lys 
385                 390                 395                 400 

Asn Trp Lys Asp Glu Asn Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg 
                405                 410                 415     

Val Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Glu 
            420                 425                 430         

Arg Leu Lys Glu Ala Gln Phe Val Val Lys Asn Glu Gln Gly Lys Tyr 
        435                 440                 445             

Leu Ala Leu Lys Ser Ala Ala Gln Gln Ala Val Asn Glu Lys Ala Ala 
    450                 455                 460                 

Ala Glu Ala Lys Gln Ala Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn 
465                 470                 475                 480 

Ala Ala Asp Lys Asn Ala Ala Gln Ala Val Val Asp Ala Ala Gln Lys 
                485                 490                 495     

Thr Tyr Asn Asp Asn Tyr Arg Ala Ala Arg Phe Gly Tyr Val Glu Val 
            500                 505                 510         

Glu Arg Lys Glu Asp Ala Leu Val Leu Thr Ser Asn Thr Asp Gly Gln 
        515                 520                 525             

Phe Gln Ile Ser Gly Leu Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr 
    530                 535                 540                 

Lys Ala Pro Glu Gly Phe Ala Lys Leu Gly Asp Val Lys Phe Glu Val 
545                 550                 555                 560 

Gly Ala Gly Ser Trp Asn Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val 
                565                 570                 575     

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Gly Ser 
            580                 585                 590         

Gly Ser Gly Gly Gly Gly Ala Ala Thr Val Phe Ala Ala Gly Thr Thr 
        595                 600                 605             

Thr Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp Met 
    610                 615                 620                 

Asp Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn Lys 
625                 630                 635                 640 

Val Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met Phe 
                645                 650                 655     

Val Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln Thr 
            660                 665                 670         

Leu Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala Met 
        675                 680                 685             

Pro Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys Phe 
    690                 695                 700                 

Asn Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile His 
705                 710                 715                 720 

Ser Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly Ser 
                725                 730                 735     

Lys Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val Asp 
            740                 745                 750         

Ala His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp Lys 
        755                 760                 765             

Asp Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys Asp 
    770                 775                 780                 

Thr Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile Val 
785                 790                 795                 800 

Thr Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser Asp 
                805                 810                 815     

Arg Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val Thr 
            820                 825                 830         

Val Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu Val 
        835                 840                 845             

Ala Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys Val 
    850                 855                 860                 

Asn Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala Thr 
865                 870                 875                 880 

Leu Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val Thr 
                885                 890                 895     

Phe Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro Asn 
            900                 905                 910         

Lys Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val Asp 
        915                 920                 925             

Ala Thr Gly Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp Leu 
    930                 935                 940                 

Val Asn Ala Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr Thr 
945                 950                 955                 960 

Asp Lys Asn Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu Tyr 
                965                 970                 975     

Lys Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Glu 
            980                 985                 990         

Ile Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu Asn 
        995                 1000                1005            

Pro Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly Lys 
    1010                1015                1020                

Lys Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala Glu 
1025                1030                1035                1040

Phe Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg Lys 
                1045                1050                1055    

Ala Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr Lys 
            1060                1065                1070        

Asp Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala Gln 
        1075                1080                1085            

Gln Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala Ala 
    1090                1095                1100                

Tyr Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val Ala 
1105                1110                1115                1120

Asp Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln Gly 
                1125                1130                1135    

Arg Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu Glu 
            1140                1145                1150        

Thr Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys Phe 
        1155                1160                1165            

Glu Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu Tyr 
    1170                1175                1180                

Thr Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys Lys 
1185                1190                1195                1200

Ile Thr Leu Gly Gly Ser Gly Gly Gly Gly Ala Ala Thr Val Phe Ala 
                1205                1210                1215    

Ala Asp Asn Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr 
            1220                1225                1230        

Ile His Lys Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr 
        1235                1240                1245            

Asn Gly Pro Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu 
    1250                1255                1260                

Thr Gly Val Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln 
1265                1270                1275                1280

Lys Tyr Asn Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp 
                1285                1290                1295    

Ser Lys Trp Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu 
            1300                1305                1310        

Lys Ile Glu Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp 
        1315                1320                1325            

Arg Thr Lys Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly 
    1330                1335                1340                

Ser Lys Ala Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn 
1345                1350                1355                1360

Gly Thr Val Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys 
                1365                1370                1375    

Pro Val Val Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln 
            1380                1385                1390        

Asn Gly Leu Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr 
        1395                1400                1405            

Ile Pro Ser Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met 
    1410                1415                1420                

Thr Glu Gly Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn 
1425                1430                1435                1440

Val Ala Met Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Asn Asn Gly 
                1445                1450                1455    

Phe Asn Leu Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys 
            1460                1465                1470        

Asp Ala Asp Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser 
        1475                1480                1485            

Leu Ala Val Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr 
    1490                1495                1500                

Gly Asn His Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn 
1505                1510                1515                1520

Asn Gly Gln Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro 
                1525                1530                1535    

Glu Gly Val Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu 
            1540                1545                1550        

Lys Val Gly Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr 
        1555                1560                1565            

Trp Ser Gly Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr 
    1570                1575                1580                

Asn Gly Tyr Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly 
1585                1590                1595                1600

Val Lys Asn Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu 
                1605                1610                1615    

Pro Arg Val Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys 
            1620                1625                1630        

Asp Thr Arg Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser 
        1635                1640                1645            

Asn Lys Tyr Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu 
    1650                1655                1660                

Lys Ala Ala Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala 
1665                1670                1675                1680

Tyr Thr Asn Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln 
                1685                1690                1695    

Ala Gln Gln Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr 
            1700                1705                1710        

Val Glu Val Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr 
        1715                1720                1725            

Asp Gly Gln Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu 
    1730                1735                1740                

Glu Glu Ile Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu 
1745                1750                1755                1760

Phe Val Val Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu 
                1765                1770                1775    

Lys Asp Val Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile 
            1780                1785                1790        

Thr Leu Gly His His His His His His 
        1795                1800    

<210>   18
<211>   5403
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence encoding SEQ ID NO: 17

<400>   18
atggctagcg cggaacaaaa aactaagaca cttacagttc ataaattatt gatgacagat   60
caagagcttg acgcttggaa ttctgatgcg attactactg caggttatga cggttcgcaa   120
aattttgaac agttcaaaca acttcaaggt gttccacaag gagtaaccga aatctctggt   180
gttgcattcg agttacagag ttatacgggt cctcaaggaa aagaacaaga aaatttaacg   240
aatgatgcgg tttggactgc ggttaataaa ggtgtgacga ctgaaacggg tgttaaattt   300
gatactgaag ttttacaagg gacatatcgt cttgtcgaag tacgtaaaga atcgacttat   360
gtcggtccaa atggtaaagt tttaacaggt atgaaagctg ttcctgcttt aattattctg   420
ccgcttgtaa accaaaatgg tgttgtagaa aatgcacatg tctatccaaa gaattctgaa   480
gacaaaccta cagcaacgaa aacatttgat actgcagcag gtttcgtaga tccaggtgaa   540
aaaggtttag caattggcac taaggtaccg tatattgtta caacaactat tccgaaaaac   600
tcaactcttg caacagcttt ctggtcagat gaaatgacag aaggtctaga ttataatggt   660
gatgtagttg ttaattataa tggtcaaccg cttgataatt ctcattacac attagaagca   720
ggtcataatg gctttatctt gaagttaaat gaaaaaggtc tggaagcaat caacggtaaa   780
gatgcagaag caacaattac gttgaagtat actgcaactt taaatgctct tgctgttgct   840
gatgtgccag aagcgaatga tgtaacattc cattatggaa acaacccagg tcatggtaac   900
actccaaaac caaacaaacc taaaaacggt gaacttacaa ttactaaaac atgggctgat   960
gctaaagatg ctcctatagc aggtgtagaa gtaacttttg atttggtaaa tgctcagaca   1020
ggtgaggtcg ttaaagtacc tggacatgaa acaggtattg tattgaatca aacaaataat   1080
tggacattta ctgctacagg tcttgataat aatacagaat ataaatttgt tgaacggaca   1140
attaagggat attctgcaga ttaccaaaca attactgaaa caggaaaaat tgctgttaaa   1200
aactggaaag atgaaaatcc agaaccaata aatcctgaag agccacgtgt aaaaacatat   1260
ggtaaaaaat tcgttaaggt tgaccaaaaa gacgaacgct taaaagaagc acaattcgtt   1320
gtgaagaatg agcaagggaa atatcttgca ctcaaatctg cagcacaaca agctgtaaat   1380
gagaaagctg ccgcagaagc gaaacaagcg ctagatgcag cgatagcagc ctatacaaat   1440
gctgcagata aaaatgcagc acaagctgta gtagatgctg cgcaaaaaac atataatgac   1500
aattacagag cagctagatt tggctatgta gaagtagaga gaaaagaaga tgcgttagtt   1560
cttacttcta acactgatgg tcaattccaa atttcaggtc ttgctgctgg aagctacacg   1620
ttggaagaaa caaaagctcc agaaggcttt gcaaaacttg gagatgtgaa gtttgaggtt   1680
ggagcaggtt cttggaatca aggtgatttc aattatttaa aagatgttca gaagaacgac   1740
gctacaaaag tagtcaacaa aaaaatcacg ggatccggca gcggtggcgg tggcgctgca   1800
acagtttttg cggctgggac gacaacaaca tctgttaccg ttcataaact attggcaaca   1860
gatggggata tggataaaat tgcaaatgag ttagaaacag gtaactatgc tggtaataaa   1920
gtgggtgttc tacctgcaaa tgcaaaagaa attgccggtg ttatgttcgt ttggacaaat   1980
actaataatg aaattattga tgaaaatggc caaactctag gagtgaatat tgatccacaa   2040
acatttaaac tctcaggggc aatgccggca actgcaatga aaaaattaac agaagctgaa   2100
ggagctaaat ttaacacggc aaatttacca gctgctaagt ataaaattta tgaaattcac   2160
agtttatcaa cttatgtcgg tgaagatgga gcaaccttaa caggttctaa agcagttcca   2220
attgaaattg aattaccatt gaacgatgtt gtggatgcgc atgtgtatcc aaaaaataca   2280
gaagcaaagc caaaaattga taaagatttc aaaggtaaag caaatccaga tacaccacgt   2340
gtagataaag atacacctgt gaaccaccaa gttggagatg ttgtagagta cgaaattgtt   2400
acaaaaattc cagcacttgc taattatgca acagcaaact ggagcgatag aatgactgaa   2460
ggtttggcat tcaacaaagg tacagtgaaa gtaactgttg atgatgttgc acttgaagca   2520
ggtgattatg ctctaacaga agtagcaact ggttttgatt tgaaattaac agatgctggt   2580
ttagctaaag tgaatgacca aaacgctgaa aaaactgtga aaatcactta ttcggcaaca   2640
ttgaatgaca aagcaattgt agaagtacca gaatctaatg atgtaacatt taactatggt   2700
aataatccag atcacgggaa tactccaaag ccgaataagc caaatgaaaa cggcgatttg   2760
acattgacca agacatgggt tgatgctaca ggtgcaccaa ttccggctgg agctgaagca   2820
acgttcgatt tggttaatgc tcagactggt aaagttgtac aaactgtaac tttgacaaca   2880
gacaaaaata cagttactgt taacggattg gataaaaata cagaatataa attcgttgaa   2940
cgtagtataa aagggtattc agcagattat caagaaatca ctacagctgg agaaattgct   3000
gtcaagaact ggaaagacga aaatccaaaa ccacttgatc caacagagcc aaaagttgtt   3060
acatatggta aaaagtttgt caaagttaat gataaagata atcgtttagc tggggcagaa   3120
tttgtaattg caaatgctga taatgctggt caatatttag cacgtaaagc agataaagtg   3180
agtcaagaag agaagcagtt ggttgttaca acaaaggatg ctttagatag agcagttgct   3240
gcttataacg ctcttactgc acaacaacaa actcagcaag aaaaagagaa agttgacaaa   3300
gctcaagctg cttataatgc tgctgtgatt gctgccaaca atgcatttga atgggtggca   3360
gataaggaca atgaaaatgt tgtgaaatta gtttctgatg cacaaggtcg ctttgaaatt   3420
acaggccttc ttgcaggtac atattactta gaagaaacaa aacagcctgc tggttatgca   3480
ttactaacta gccgtcagaa atttgaagtc actgcaactt cttattcagc gactggacaa   3540
ggcattgagt atactgctgg ttcaggtaaa gatgacgcta caaaagtagt caacaaaaaa   3600
atcactctcg agggcagcgg tggcggtggc gctgcaacag tttttgcggc ggacaatgtt   3660
agtacagcac cagatgctgt tactaaaact ttaacaatcc ataagttact gctctcagaa   3720
gatgatttaa agacttggga tacaaacggt cctaaaggat atgatggaac tcaatctagt   3780
ttaaaagatt taactggagt tgtagctgag gaaattccaa atgtatactt tgaattacaa   3840
aagtataatt tgactgatgg taaggaaaaa gaaaatctta aagatgatag taaatggaca   3900
acagttcatg gtggtttgac aactaaagat ggacttaaaa ttgaaaccag tactcttaaa   3960
ggtgtgtatc gtattcgtga ggatagaaca aagactacct atgttggtcc taatgggcaa   4020
gtattaacag gttcaaaagc cgtacctgct cttgtaactc ttccacttgt taacaataat   4080
ggtacagtaa ttgatgcaca tgttttccct aaaaattcat ataataaacc agttgtagat   4140
aaaagaattg ctgatacttt gaattataac gatcaaaatg gtctgtctat cggtactaaa   4200
atcccatatg ttgttaatac aacaattcca agtaatgcaa catttgcaac ttcattttgg   4260
tcagatgaaa tgacagaagg tctaacttat aatgaagatg taacaattac tttgaataat   4320
gtagctatgg atcaagctga ttatgaagtc actaaaggaa ataatggctt taacttaaaa   4380
ttaacagaag caggtttagc taaaattaat ggtaaggatg cagaccaaaa aatccaaatt   4440
acttactcag ctactttgaa ctcacttgct gttgcagaca ttcctgaaag taacgatatt   4500
acatatcatt acggaaatca tcaagatcat gggaatactc caaaaccaac taaacctaat   4560
aatggtcaaa ttacagtaac taagacatgg gacagtcaac ctgctcctga gggggtgaaa   4620
gcgactgttc aacttgtaaa tgccaagact ggtgagaaag tcggtgctcc tgtagaactt   4680
tcagaaaata attggacata tacttggagt ggtctagata attctattga atacaaagtt   4740
gaagaagaat ataatggata ctcagctgaa tacacagtag agagcaaagg gaagttgggg   4800
gtaaaaaact ggaaagataa taacccagct ccaatcaatc ctgaagaacc acgtgtaaaa   4860
acatacggta aaaagtttgt caaagtagac caaaaagata ctcgtctaga aaatgcgcag   4920
ttcgttgtta aaaaagcaga tagcaataaa tatattgcct ttaagtcaac tgcacaacaa   4980
gctgcagatg aaaaagcagc agcaactgca aaacaaaaat tggatgcagc ggtagcagct   5040
tacacaaatg ctgcagataa gcaagccgct caagctctag tagatcaagc acagcaagaa   5100
tacaatgtag cttacaaaga agccaaattt ggttatgttg aagtagctgg aaaagatgaa   5160
gcaatggttc ttacttctaa tacggatggt caattccaaa tttcaggtct tgctgctggt   5220
acttataaat tagaagaaat taaagctcca gaaggttttg cgaaaattga tgatgtagaa   5280
tttgttgttg gagcaggttc ttggaatcaa ggtgagttta attacttaaa agatgttcaa   5340
aagaatgacg ctacaaaagt agtcaacaaa aaaatcactc tcgagcacca ccaccaccac   5400
cac                                                                 5403

<210>   19
<211>   1801
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   RrgB II-III-I

<400>   19
Met Ala Ser Ala Ala Thr Val Phe Ala Ala Asp Asn Val Ser Thr Ala 
1               5                   10                  15      

Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys Leu Leu Leu Ser 
            20                  25                  30          

Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro Lys Gly Tyr Asp 
        35                  40                  45              

Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val Val Ala Glu Glu 
    50                  55                  60                  

Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn Leu Thr Asp Gly 
65                  70                  75                  80  

Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp Thr Thr Val His 
                85                  90                  95      

Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu Thr Ser Thr Leu 
            100                 105                 110         

Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys Thr Thr Tyr Val 
        115                 120                 125             

Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala Val Pro Ala Leu 
    130                 135                 140                 

Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val Ile Asp Ala His 
145                 150                 155                 160 

Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val Asp Lys Arg Ile 
                165                 170                 175     

Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu Ser Ile Gly Thr 
            180                 185                 190         

Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser Asn Ala Thr Phe 
        195                 200                 205             

Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly Leu Thr Tyr Asn 
    210                 215                 220                 

Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met Asp Gln Ala Asp 
225                 230                 235                 240 

Tyr Glu Val Thr Lys Gly Asn Asn Gly Phe Asn Leu Lys Leu Thr Glu 
                245                 250                 255     

Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp Gln Lys Ile Gln 
            260                 265                 270         

Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val Ala Asp Ile Pro 
        275                 280                 285             

Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His Gln Asp His Gly 
    290                 295                 300                 

Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln Ile Thr Val Thr 
305                 310                 315                 320 

Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val Lys Ala Thr Val 
                325                 330                 335     

Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly Ala Pro Val Glu 
            340                 345                 350         

Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly Leu Asp Asn Ser 
        355                 360                 365             

Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr Ser Ala Glu Tyr 
    370                 375                 380                 

Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn Trp Lys Asp Asn 
385                 390                 395                 400 

Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly 
                405                 410                 415     

Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg Leu Glu Asn Ala 
            420                 425                 430         

Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr Ile Ala Phe Lys 
        435                 440                 445             

Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala Ala Thr Ala Lys 
    450                 455                 460                 

Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn Ala Ala Asp Lys 
465                 470                 475                 480 

Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln Glu Tyr Asn Val 
                485                 490                 495     

Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val Ala Gly Lys Asp 
            500                 505                 510         

Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser 
        515                 520                 525             

Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile Lys Ala Pro Glu 
    530                 535                 540                 

Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val Gly Ala Gly Ser 
545                 550                 555                 560 

Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp 
                565                 570                 575     

Ala Thr Lys Val Val Asn Lys Lys Ile Thr Gly Ser Gly Ser Gly Gly 
            580                 585                 590         

Gly Gly Ala Glu Gln Lys Thr Lys Thr Leu Thr Val His Lys Leu Leu 
        595                 600                 605             

Met Thr Asp Gln Glu Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr Thr 
    610                 615                 620                 

Ala Gly Tyr Asp Gly Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu Gln 
625                 630                 635                 640 

Gly Val Pro Gln Gly Val Thr Glu Ile Ser Gly Val Ala Phe Glu Leu 
                645                 650                 655     

Gln Ser Tyr Thr Gly Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr Asn 
            660                 665                 670         

Asp Ala Val Trp Thr Ala Val Asn Lys Gly Val Thr Thr Glu Thr Gly 
        675                 680                 685             

Val Lys Phe Asp Thr Glu Val Leu Gln Gly Thr Tyr Arg Leu Val Glu 
    690                 695                 700                 

Val Arg Lys Glu Ser Thr Tyr Val Gly Pro Asn Gly Lys Val Leu Thr 
705                 710                 715                 720 

Gly Met Lys Ala Val Pro Ala Leu Ile Ile Leu Pro Leu Val Asn Gln 
                725                 730                 735     

Asn Gly Val Val Glu Asn Ala His Val Tyr Pro Lys Asn Ser Glu Asp 
            740                 745                 750         

Lys Pro Thr Ala Thr Lys Thr Phe Asp Thr Ala Ala Gly Phe Val Asp 
        755                 760                 765             

Pro Gly Glu Lys Gly Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile Val 
    770                 775                 780                 

Thr Thr Thr Ile Pro Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp Ser 
785                 790                 795                 800 

Asp Glu Met Thr Glu Gly Leu Asp Tyr Asn Gly Asp Val Val Val Asn 
                805                 810                 815     

Tyr Asn Gly Gln Pro Leu Asp Asn Ser His Tyr Thr Leu Glu Ala Gly 
            820                 825                 830         

His Asn Gly Phe Ile Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala Ile 
        835                 840                 845             

Asn Gly Lys Asp Ala Glu Ala Thr Ile Thr Leu Lys Tyr Thr Ala Thr 
    850                 855                 860                 

Leu Asn Ala Leu Ala Val Ala Asp Val Pro Glu Ala Asn Asp Val Thr 
865                 870                 875                 880 

Phe His Tyr Gly Asn Asn Pro Gly His Gly Asn Thr Pro Lys Pro Asn 
                885                 890                 895     

Lys Pro Lys Asn Gly Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp Ala 
            900                 905                 910         

Lys Asp Ala Pro Ile Ala Gly Val Glu Val Thr Phe Asp Leu Val Asn 
        915                 920                 925             

Ala Gln Thr Gly Glu Val Val Lys Val Pro Gly His Glu Thr Gly Ile 
    930                 935                 940                 

Val Leu Asn Gln Thr Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu Asp 
945                 950                 955                 960 

Asn Asn Thr Glu Tyr Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr Ser 
                965                 970                 975     

Ala Asp Tyr Gln Thr Ile Thr Glu Thr Gly Lys Ile Ala Val Lys Asn 
            980                 985                 990         

Trp Lys Asp Glu Asn Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg Val 
        995                 1000                1005            

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Glu Arg 
    1010                1015                1020                

Leu Lys Glu Ala Gln Phe Val Val Lys Asn Glu Gln Gly Lys Tyr Leu 
1025                1030                1035                1040

Ala Leu Lys Ser Ala Ala Gln Gln Ala Val Asn Glu Lys Ala Ala Ala 
                1045                1050                1055    

Glu Ala Lys Gln Ala Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala 
            1060                1065                1070        

Ala Asp Lys Asn Ala Ala Gln Ala Val Val Asp Ala Ala Gln Lys Thr 
        1075                1080                1085            

Tyr Asn Asp Asn Tyr Arg Ala Ala Arg Phe Gly Tyr Val Glu Val Glu 
    1090                1095                1100                

Arg Lys Glu Asp Ala Leu Val Leu Thr Ser Asn Thr Asp Gly Gln Phe 
1105                1110                1115                1120

Gln Ile Ser Gly Leu Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr Lys 
                1125                1130                1135    

Ala Pro Glu Gly Phe Ala Lys Leu Gly Asp Val Lys Phe Glu Val Gly 
            1140                1145                1150        

Ala Gly Ser Trp Asn Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val Gln 
        1155                1160                1165            

Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Leu Gly Gly 
    1170                1175                1180                

Ser Gly Gly Gly Gly Ala Ala Thr Val Phe Ala Ala Gly Thr Thr Thr 
1185                1190                1195                1200

Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp Met Asp 
                1205                1210                1215    

Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn Lys Val 
            1220                1225                1230        

Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met Phe Val 
        1235                1240                1245            

Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln Thr Leu 
    1250                1255                1260                

Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala Met Pro 
1265                1270                1275                1280

Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys Phe Asn 
                1285                1290                1295    

Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile His Ser 
            1300                1305                1310        

Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly Ser Lys 
        1315                1320                1325            

Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val Asp Ala 
    1330                1335                1340                

His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp Lys Asp 
1345                1350                1355                1360

Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys Asp Thr 
                1365                1370                1375    

Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile Val Thr 
            1380                1385                1390        

Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser Asp Arg 
        1395                1400                1405            

Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val Thr Val 
    1410                1415                1420                

Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu Val Ala 
1425                1430                1435                1440

Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys Val Asn 
                1445                1450                1455    

Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala Thr Leu 
            1460                1465                1470        

Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val Thr Phe 
        1475                1480                1485            

Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro Asn Lys 
    1490                1495                1500                

Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val Asp Ala 
1505                1510                1515                1520

Thr Gly Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp Leu Val 
                1525                1530                1535    

Asn Ala Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr Thr Asp 
            1540                1545                1550        

Lys Asn Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu Tyr Lys 
        1555                1560                1565            

Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Glu Ile 
    1570                1575                1580                

Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu Asn Pro 
1585                1590                1595                1600

Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly Lys Lys 
                1605                1610                1615    

Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala Glu Phe 
            1620                1625                1630        

Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg Lys Ala 
        1635                1640                1645            

Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr Lys Asp 
    1650                1655                1660                

Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala Gln Gln 
1665                1670                1675                1680

Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala Ala Tyr 
                1685                1690                1695    

Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val Ala Asp 
            1700                1705                1710        

Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln Gly Arg 
        1715                1720                1725            

Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu Glu Thr 
    1730                1735                1740                

Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys Phe Glu 
1745                1750                1755                1760

Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu Tyr Thr 
                1765                1770                1775    

Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys Lys Ile 
            1780                1785                1790        

Thr Leu Gly His His His His His His 
        1795                1800    

<210>   20
<211>   5403
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence encoding SEQ ID NO: 19

<400>   20
atggctagcg ctgcaacagt ttttgcggcg gacaatgtta gtacagcacc agatgctgtt   60
actaaaactt taacaatcca taagttactg ctctcagaag atgatttaaa gacttgggat   120
acaaacggtc ctaaaggata tgatggaact caatctagtt taaaagattt aactggagtt   180
gtagctgagg aaattccaaa tgtatacttt gaattacaaa agtataattt gactgatggt   240
aaggaaaaag aaaatcttaa agatgatagt aaatggacaa cagttcatgg tggtttgaca   300
actaaagatg gacttaaaat tgaaaccagt actcttaaag gtgtgtatcg tattcgtgag   360
gatagaacaa agactaccta tgttggtcct aatgggcaag tattaacagg ttcaaaagcc   420
gtacctgctc ttgtaactct tccacttgtt aacaataatg gtacagtaat tgatgcacat   480
gttttcccta aaaattcata taataaacca gttgtagata aaagaattgc tgatactttg   540
aattataacg atcaaaatgg tctgtctatc ggtactaaaa tcccatatgt tgttaataca   600
acaattccaa gtaatgcaac atttgcaact tcattttggt cagatgaaat gacagaaggt   660
ctaacttata atgaagatgt aacaattact ttgaataatg tagctatgga tcaagctgat   720
tatgaagtca ctaaaggaaa taatggcttt aacttaaaat taacagaagc aggtttagct   780
aaaattaatg gtaaggatgc agaccaaaaa atccaaatta cttactcagc tactttgaac   840
tcacttgctg ttgcagacat tcctgaaagt aacgatatta catatcatta cggaaatcat   900
caagatcatg ggaatactcc aaaaccaact aaacctaata atggtcaaat tacagtaact   960
aagacatggg acagtcaacc tgctcctgag ggggtgaaag cgactgttca acttgtaaat   1020
gccaagactg gtgagaaagt cggtgctcct gtagaacttt cagaaaataa ttggacatat   1080
acttggagtg gtctagataa ttctattgaa tacaaagttg aagaagaata taatggatac   1140
tcagctgaat acacagtaga gagcaaaggg aagttggggg taaaaaactg gaaagataat   1200
aacccagctc caatcaatcc tgaagaacca cgtgtaaaaa catacggtaa aaagtttgtc   1260
aaagtagacc aaaaagatac tcgtctagaa aatgcgcagt tcgttgttaa aaaagcagat   1320
agcaataaat atattgcctt taagtcaact gcacaacaag ctgcagatga aaaagcagca   1380
gcaactgcaa aacaaaaatt ggatgcagcg gtagcagctt acacaaatgc tgcagataag   1440
caagccgctc aagctctagt agatcaagca cagcaagaat acaatgtagc ttacaaagaa   1500
gccaaatttg gttatgttga agtagctgga aaagatgaag caatggttct tacttctaat   1560
acggatggtc aattccaaat ttcaggtctt gctgctggta cttataaatt agaagaaatt   1620
aaagctccag aaggttttgc gaaaattgat gatgtagaat ttgttgttgg agcaggttct   1680
tggaatcaag gtgagtttaa ttacttaaaa gatgttcaaa agaatgacgc tacaaaagta   1740
gtcaacaaaa aaatcactgg atccggcagc ggtggcggtg gcgcggaaca aaaaactaag   1800
acacttacag ttcataaatt attgatgaca gatcaagagc ttgacgcttg gaattctgat   1860
gcgattacta ctgcaggtta tgacggttcg caaaattttg aacagttcaa acaacttcaa   1920
ggtgttccac aaggagtaac cgaaatctct ggtgttgcat tcgagttaca gagttatacg   1980
ggtcctcaag gaaaagaaca agaaaattta acgaatgatg cggtttggac tgcggttaat   2040
aaaggtgtga cgactgaaac gggtgttaaa tttgatactg aagttttaca agggacatat   2100
cgtcttgtcg aagtacgtaa agaatcgact tatgtcggtc caaatggtaa agttttaaca   2160
ggtatgaaag ctgttcctgc tttaattatt ctgccgcttg taaaccaaaa tggtgttgta   2220
gaaaatgcac atgtctatcc aaagaattct gaagacaaac ctacagcaac gaaaacattt   2280
gatactgcag caggtttcgt agatccaggt gaaaaaggtt tagcaattgg cactaaggta   2340
ccgtatattg ttacaacaac tattccgaaa aactcaactc ttgcaacagc tttctggtca   2400
gatgaaatga cagaaggtct agattataat ggtgatgtag ttgttaatta taatggtcaa   2460
ccgcttgata attctcatta cacattagaa gcaggtcata atggctttat cttgaagtta   2520
aatgaaaaag gtctggaagc aatcaacggt aaagatgcag aagcaacaat tacgttgaag   2580
tatactgcaa ctttaaatgc tcttgctgtt gctgatgtgc cagaagcgaa tgatgtaaca   2640
ttccattatg gaaacaaccc aggtcatggt aacactccaa aaccaaacaa acctaaaaac   2700
ggtgaactta caattactaa aacatgggct gatgctaaag atgctcctat agcaggtgta   2760
gaagtaactt ttgatttggt aaatgctcag acaggtgagg tcgttaaagt acctggacat   2820
gaaacaggta ttgtattgaa tcaaacaaat aattggacat ttactgctac aggtcttgat   2880
aataatacag aatataaatt tgttgaacgg acaattaagg gatattctgc agattaccaa   2940
acaattactg aaacaggaaa aattgctgtt aaaaactgga aagatgaaaa tccagaacca   3000
ataaatcctg aagagccacg tgtaaaaaca tatggtaaaa aattcgttaa ggttgaccaa   3060
aaagacgaac gcttaaaaga agcacaattc gttgtgaaga atgagcaagg gaaatatctt   3120
gcactcaaat ctgcagcaca acaagctgta aatgagaaag ctgccgcaga agcgaaacaa   3180
gcgctagatg cagcgatagc agcctataca aatgctgcag ataaaaatgc agcacaagct   3240
gtagtagatg ctgcgcaaaa aacatataat gacaattaca gagcagctag atttggctat   3300
gtagaagtag agagaaaaga agatgcgtta gttcttactt ctaacactga tggtcaattc   3360
caaatttcag gtcttgctgc tggaagctac acgttggaag aaacaaaagc tccagaaggc   3420
tttgcaaaac ttggagatgt gaagtttgag gttggagcag gttcttggaa tcaaggtgat   3480
ttcaattatt taaaagatgt tcagaagaac gacgctacaa aagtagtcaa caaaaaaatc   3540
acgctcgagg gcagcggtgg cggtggcgct gcaacagttt ttgcggctgg gacgacaaca   3600
acatctgtta ccgttcataa actattggca acagatgggg atatggataa aattgcaaat   3660
gagttagaaa caggtaacta tgctggtaat aaagtgggtg ttctacctgc aaatgcaaaa   3720
gaaattgccg gtgttatgtt cgtttggaca aatactaata atgaaattat tgatgaaaat   3780
ggccaaactc taggagtgaa tattgatcca caaacattta aactctcagg ggcaatgccg   3840
gcaactgcaa tgaaaaaatt aacagaagct gaaggagcta aatttaacac ggcaaattta   3900
ccagctgcta agtataaaat ttatgaaatt cacagtttat caacttatgt cggtgaagat   3960
ggagcaacct taacaggttc taaagcagtt ccaattgaaa ttgaattacc attgaacgat   4020
gttgtggatg cgcatgtgta tccaaaaaat acagaagcaa agccaaaaat tgataaagat   4080
ttcaaaggta aagcaaatcc agatacacca cgtgtagata aagatacacc tgtgaaccac   4140
caagttggag atgttgtaga gtacgaaatt gttacaaaaa ttccagcact tgctaattat   4200
gcaacagcaa actggagcga tagaatgact gaaggtttgg cattcaacaa aggtacagtg   4260
aaagtaactg ttgatgatgt tgcacttgaa gcaggtgatt atgctctaac agaagtagca   4320
actggttttg atttgaaatt aacagatgct ggtttagcta aagtgaatga ccaaaacgct   4380
gaaaaaactg tgaaaatcac ttattcggca acattgaatg acaaagcaat tgtagaagta   4440
ccagaatcta atgatgtaac atttaactat ggtaataatc cagatcacgg gaatactcca   4500
aagccgaata agccaaatga aaacggcgat ttgacattga ccaagacatg ggttgatgct   4560
acaggtgcac caattccggc tggagctgaa gcaacgttcg atttggttaa tgctcagact   4620
ggtaaagttg tacaaactgt aactttgaca acagacaaaa atacagttac tgttaacgga   4680
ttggataaaa atacagaata taaattcgtt gaacgtagta taaaagggta ttcagcagat   4740
tatcaagaaa tcactacagc tggagaaatt gctgtcaaga actggaaaga cgaaaatcca   4800
aaaccacttg atccaacaga gccaaaagtt gttacatatg gtaaaaagtt tgtcaaagtt   4860
aatgataaag ataatcgttt agctggggca gaatttgtaa ttgcaaatgc tgataatgct   4920
ggtcaatatt tagcacgtaa agcagataaa gtgagtcaag aagagaagca gttggttgtt   4980
acaacaaagg atgctttaga tagagcagtt gctgcttata acgctcttac tgcacaacaa   5040
caaactcagc aagaaaaaga gaaagttgac aaagctcaag ctgcttataa tgctgctgtg   5100
attgctgcca acaatgcatt tgaatgggtg gcagataagg acaatgaaaa tgttgtgaaa   5160
ttagtttctg atgcacaagg tcgctttgaa attacaggcc ttcttgcagg tacatattac   5220
ttagaagaaa caaaacagcc tgctggttat gcattactaa ctagccgtca gaaatttgaa   5280
gtcactgcaa cttcttattc agcgactgga caaggcattg agtatactgc tggttcaggt   5340
aaagatgacg ctacaaaagt agtcaacaaa aaaatcactc tcgagcacca ccaccaccac   5400
cac                                                                 5403

<210>   21
<211>   1801
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   RrgB II-I-III

<400>   21
Met Ala Ser Ala Ala Thr Val Phe Ala Ala Asp Asn Val Ser Thr Ala 
1               5                   10                  15      

Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys Leu Leu Leu Ser 
            20                  25                  30          

Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro Lys Gly Tyr Asp 
        35                  40                  45              

Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val Val Ala Glu Glu 
    50                  55                  60                  

Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn Leu Thr Asp Gly 
65                  70                  75                  80  

Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp Thr Thr Val His 
                85                  90                  95      

Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu Thr Ser Thr Leu 
            100                 105                 110         

Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys Thr Thr Tyr Val 
        115                 120                 125             

Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala Val Pro Ala Leu 
    130                 135                 140                 

Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val Ile Asp Ala His 
145                 150                 155                 160 

Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val Asp Lys Arg Ile 
                165                 170                 175     

Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu Ser Ile Gly Thr 
            180                 185                 190         

Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser Asn Ala Thr Phe 
        195                 200                 205             

Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly Leu Thr Tyr Asn 
    210                 215                 220                 

Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met Asp Gln Ala Asp 
225                 230                 235                 240 

Tyr Glu Val Thr Lys Gly Asn Asn Gly Phe Asn Leu Lys Leu Thr Glu 
                245                 250                 255     

Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp Gln Lys Ile Gln 
            260                 265                 270         

Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val Ala Asp Ile Pro 
        275                 280                 285             

Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His Gln Asp His Gly 
    290                 295                 300                 

Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln Ile Thr Val Thr 
305                 310                 315                 320 

Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val Lys Ala Thr Val 
                325                 330                 335     

Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly Ala Pro Val Glu 
            340                 345                 350         

Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly Leu Asp Asn Ser 
        355                 360                 365             

Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr Ser Ala Glu Tyr 
    370                 375                 380                 

Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn Trp Lys Asp Asn 
385                 390                 395                 400 

Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly 
                405                 410                 415     

Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg Leu Glu Asn Ala 
            420                 425                 430         

Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr Ile Ala Phe Lys 
        435                 440                 445             

Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala Ala Thr Ala Lys 
    450                 455                 460                 

Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn Ala Ala Asp Lys 
465                 470                 475                 480 

Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln Glu Tyr Asn Val 
                485                 490                 495     

Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val Ala Gly Lys Asp 
            500                 505                 510         

Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser 
        515                 520                 525             

Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile Lys Ala Pro Glu 
    530                 535                 540                 

Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val Gly Ala Gly Ser 
545                 550                 555                 560 

Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp 
                565                 570                 575     

Ala Thr Lys Val Val Asn Lys Lys Ile Thr Gly Ser Gly Ser Gly Gly 
            580                 585                 590         

Gly Gly Ala Ala Thr Val Phe Ala Ala Gly Thr Thr Thr Thr Ser Val 
        595                 600                 605             

Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp Met Asp Lys Ile Ala 
    610                 615                 620                 

Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn Lys Val Gly Val Leu 
625                 630                 635                 640 

Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met Phe Val Trp Thr Asn 
                645                 650                 655     

Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln Thr Leu Gly Val Asn 
            660                 665                 670         

Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala Met Pro Ala Thr Ala 
        675                 680                 685             

Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys Phe Asn Thr Ala Asn 
    690                 695                 700                 

Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile His Ser Leu Ser Thr 
705                 710                 715                 720 

Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly Ser Lys Ala Val Pro 
                725                 730                 735     

Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val Asp Ala His Val Tyr 
            740                 745                 750         

Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp Lys Asp Phe Lys Gly 
        755                 760                 765             

Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys Asp Thr Pro Val Asn 
    770                 775                 780                 

His Gln Val Gly Asp Val Val Glu Tyr Glu Ile Val Thr Lys Ile Pro 
785                 790                 795                 800 

Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser Asp Arg Met Thr Glu 
                805                 810                 815     

Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val Thr Val Asp Asp Val 
            820                 825                 830         

Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu Val Ala Thr Gly Phe 
        835                 840                 845             

Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys Val Asn Asp Gln Asn 
    850                 855                 860                 

Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala Thr Leu Asn Asp Lys 
865                 870                 875                 880 

Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val Thr Phe Asn Tyr Gly 
                885                 890                 895     

Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro Asn Lys Pro Asn Glu 
            900                 905                 910         

Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val Asp Ala Thr Gly Ala 
        915                 920                 925             

Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp Leu Val Asn Ala Gln 
    930                 935                 940                 

Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr Thr Asp Lys Asn Thr 
945                 950                 955                 960 

Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu Tyr Lys Phe Val Glu 
                965                 970                 975     

Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Glu Ile Thr Thr Ala 
            980                 985                 990         

Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu Asn Pro Lys Pro Leu 
        995                 1000                1005            

Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly Lys Lys Phe Val Lys 
    1010                1015                1020                

Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala Glu Phe Val Ile Ala 
1025                1030                1035                1040

Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg Lys Ala Asp Lys Val 
                1045                1050                1055    

Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr Lys Asp Ala Leu Asp 
            1060                1065                1070        

Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala Gln Gln Gln Thr Gln 
        1075                1080                1085            

Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala Ala Tyr Asn Ala Ala 
    1090                1095                1100                

Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val Ala Asp Lys Asp Asn 
1105                1110                1115                1120

Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln Gly Arg Phe Glu Ile 
                1125                1130                1135    

Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu Glu Thr Lys Gln Pro 
            1140                1145                1150        

Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys Phe Glu Val Thr Ala 
        1155                1160                1165            

Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu Tyr Thr Ala Gly Ser 
    1170                1175                1180                

Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Leu Gly 
1185                1190                1195                1200

Gly Ser Gly Gly Gly Gly Ala Glu Gln Lys Thr Lys Thr Leu Thr Val 
                1205                1210                1215    

His Lys Leu Leu Met Thr Asp Gln Glu Leu Asp Ala Trp Asn Ser Asp 
            1220                1225                1230        

Ala Ile Thr Thr Ala Gly Tyr Asp Gly Ser Gln Asn Phe Glu Gln Phe 
        1235                1240                1245            

Lys Gln Leu Gln Gly Val Pro Gln Gly Val Thr Glu Ile Ser Gly Val 
    1250                1255                1260                

Ala Phe Glu Leu Gln Ser Tyr Thr Gly Pro Gln Gly Lys Glu Gln Glu 
1265                1270                1275                1280

Asn Leu Thr Asn Asp Ala Val Trp Thr Ala Val Asn Lys Gly Val Thr 
                1285                1290                1295    

Thr Glu Thr Gly Val Lys Phe Asp Thr Glu Val Leu Gln Gly Thr Tyr 
            1300                1305                1310        

Arg Leu Val Glu Val Arg Lys Glu Ser Thr Tyr Val Gly Pro Asn Gly 
        1315                1320                1325            

Lys Val Leu Thr Gly Met Lys Ala Val Pro Ala Leu Ile Ile Leu Pro 
    1330                1335                1340                

Leu Val Asn Gln Asn Gly Val Val Glu Asn Ala His Val Tyr Pro Lys 
1345                1350                1355                1360

Asn Ser Glu Asp Lys Pro Thr Ala Thr Lys Thr Phe Asp Thr Ala Ala 
                1365                1370                1375    

Gly Phe Val Asp Pro Gly Glu Lys Gly Leu Ala Ile Gly Thr Lys Val 
            1380                1385                1390        

Pro Tyr Ile Val Thr Thr Thr Ile Pro Lys Asn Ser Thr Leu Ala Thr 
        1395                1400                1405            

Ala Phe Trp Ser Asp Glu Met Thr Glu Gly Leu Asp Tyr Asn Gly Asp 
    1410                1415                1420                

Val Val Val Asn Tyr Asn Gly Gln Pro Leu Asp Asn Ser His Tyr Thr 
1425                1430                1435                1440

Leu Glu Ala Gly His Asn Gly Phe Ile Leu Lys Leu Asn Glu Lys Gly 
                1445                1450                1455    

Leu Glu Ala Ile Asn Gly Lys Asp Ala Glu Ala Thr Ile Thr Leu Lys 
            1460                1465                1470        

Tyr Thr Ala Thr Leu Asn Ala Leu Ala Val Ala Asp Val Pro Glu Ala 
        1475                1480                1485            

Asn Asp Val Thr Phe His Tyr Gly Asn Asn Pro Gly His Gly Asn Thr 
    1490                1495                1500                

Pro Lys Pro Asn Lys Pro Lys Asn Gly Glu Leu Thr Ile Thr Lys Thr 
1505                1510                1515                1520

Trp Ala Asp Ala Lys Asp Ala Pro Ile Ala Gly Val Glu Val Thr Phe 
                1525                1530                1535    

Asp Leu Val Asn Ala Gln Thr Gly Glu Val Val Lys Val Pro Gly His 
            1540                1545                1550        

Glu Thr Gly Ile Val Leu Asn Gln Thr Asn Asn Trp Thr Phe Thr Ala 
        1555                1560                1565            

Thr Gly Leu Asp Asn Asn Thr Glu Tyr Lys Phe Val Glu Arg Thr Ile 
    1570                1575                1580                

Lys Gly Tyr Ser Ala Asp Tyr Gln Thr Ile Thr Glu Thr Gly Lys Ile 
1585                1590                1595                1600

Ala Val Lys Asn Trp Lys Asp Glu Asn Pro Glu Pro Ile Asn Pro Glu 
                1605                1610                1615    

Glu Pro Arg Val Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln 
            1620                1625                1630        

Lys Asp Glu Arg Leu Lys Glu Ala Gln Phe Val Val Lys Asn Glu Gln 
        1635                1640                1645            

Gly Lys Tyr Leu Ala Leu Lys Ser Ala Ala Gln Gln Ala Val Asn Glu 
    1650                1655                1660                

Lys Ala Ala Ala Glu Ala Lys Gln Ala Leu Asp Ala Ala Ile Ala Ala 
1665                1670                1675                1680

Tyr Thr Asn Ala Ala Asp Lys Asn Ala Ala Gln Ala Val Val Asp Ala 
                1685                1690                1695    

Ala Gln Lys Thr Tyr Asn Asp Asn Tyr Arg Ala Ala Arg Phe Gly Tyr 
            1700                1705                1710        

Val Glu Val Glu Arg Lys Glu Asp Ala Leu Val Leu Thr Ser Asn Thr 
        1715                1720                1725            

Asp Gly Gln Phe Gln Ile Ser Gly Leu Ala Ala Gly Ser Tyr Thr Leu 
    1730                1735                1740                

Glu Glu Thr Lys Ala Pro Glu Gly Phe Ala Lys Leu Gly Asp Val Lys 
1745                1750                1755                1760

Phe Glu Val Gly Ala Gly Ser Trp Asn Gln Gly Asp Phe Asn Tyr Leu 
                1765                1770                1775    

Lys Asp Val Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile 
            1780                1785                1790        

Thr Leu Gly His His His His His His 
        1795                1800    

<210>   22
<211>   5403
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence encoding SEQ ID NO: 21

<400>   22
atggctagcg ctgcaacagt ttttgcggcg gacaatgtta gtacagcacc agatgctgtt   60
actaaaactt taacaatcca taagttactg ctctcagaag atgatttaaa gacttgggat   120
acaaacggtc ctaaaggata tgatggaact caatctagtt taaaagattt aactggagtt   180
gtagctgagg aaattccaaa tgtatacttt gaattacaaa agtataattt gactgatggt   240
aaggaaaaag aaaatcttaa agatgatagt aaatggacaa cagttcatgg tggtttgaca   300
actaaagatg gacttaaaat tgaaaccagt actcttaaag gtgtgtatcg tattcgtgag   360
gatagaacaa agactaccta tgttggtcct aatgggcaag tattaacagg ttcaaaagcc   420
gtacctgctc ttgtaactct tccacttgtt aacaataatg gtacagtaat tgatgcacat   480
gttttcccta aaaattcata taataaacca gttgtagata aaagaattgc tgatactttg   540
aattataacg atcaaaatgg tctgtctatc ggtactaaaa tcccatatgt tgttaataca   600
acaattccaa gtaatgcaac atttgcaact tcattttggt cagatgaaat gacagaaggt   660
ctaacttata atgaagatgt aacaattact ttgaataatg tagctatgga tcaagctgat   720
tatgaagtca ctaaaggaaa taatggcttt aacttaaaat taacagaagc aggtttagct   780
aaaattaatg gtaaggatgc agaccaaaaa atccaaatta cttactcagc tactttgaac   840
tcacttgctg ttgcagacat tcctgaaagt aacgatatta catatcatta cggaaatcat   900
caagatcatg ggaatactcc aaaaccaact aaacctaata atggtcaaat tacagtaact   960
aagacatggg acagtcaacc tgctcctgag ggggtgaaag cgactgttca acttgtaaat   1020
gccaagactg gtgagaaagt cggtgctcct gtagaacttt cagaaaataa ttggacatat   1080
acttggagtg gtctagataa ttctattgaa tacaaagttg aagaagaata taatggatac   1140
tcagctgaat acacagtaga gagcaaaggg aagttggggg taaaaaactg gaaagataat   1200
aacccagctc caatcaatcc tgaagaacca cgtgtaaaaa catacggtaa aaagtttgtc   1260
aaagtagacc aaaaagatac tcgtctagaa aatgcgcagt tcgttgttaa aaaagcagat   1320
agcaataaat atattgcctt taagtcaact gcacaacaag ctgcagatga aaaagcagca   1380
gcaactgcaa aacaaaaatt ggatgcagcg gtagcagctt acacaaatgc tgcagataag   1440
caagccgctc aagctctagt agatcaagca cagcaagaat acaatgtagc ttacaaagaa   1500
gccaaatttg gttatgttga agtagctgga aaagatgaag caatggttct tacttctaat   1560
acggatggtc aattccaaat ttcaggtctt gctgctggta cttataaatt agaagaaatt   1620
aaagctccag aaggttttgc gaaaattgat gatgtagaat ttgttgttgg agcaggttct   1680
tggaatcaag gtgagtttaa ttacttaaaa gatgttcaaa agaatgacgc tacaaaagta   1740
gtcaacaaaa aaatcactgg atccggcagc ggtggcggtg gcgctgcaac agtttttgcg   1800
gctgggacga caacaacatc tgttaccgtt cataaactat tggcaacaga tggggatatg   1860
gataaaattg caaatgagtt agaaacaggt aactatgctg gtaataaagt gggtgttcta   1920
cctgcaaatg caaaagaaat tgccggtgtt atgttcgttt ggacaaatac taataatgaa   1980
attattgatg aaaatggcca aactctagga gtgaatattg atccacaaac atttaaactc   2040
tcaggggcaa tgccggcaac tgcaatgaaa aaattaacag aagctgaagg agctaaattt   2100
aacacggcaa atttaccagc tgctaagtat aaaatttatg aaattcacag tttatcaact   2160
tatgtcggtg aagatggagc aaccttaaca ggttctaaag cagttccaat tgaaattgaa   2220
ttaccattga acgatgttgt ggatgcgcat gtgtatccaa aaaatacaga agcaaagcca   2280
aaaattgata aagatttcaa aggtaaagca aatccagata caccacgtgt agataaagat   2340
acacctgtga accaccaagt tggagatgtt gtagagtacg aaattgttac aaaaattcca   2400
gcacttgcta attatgcaac agcaaactgg agcgatagaa tgactgaagg tttggcattc   2460
aacaaaggta cagtgaaagt aactgttgat gatgttgcac ttgaagcagg tgattatgct   2520
ctaacagaag tagcaactgg ttttgatttg aaattaacag atgctggttt agctaaagtg   2580
aatgaccaaa acgctgaaaa aactgtgaaa atcacttatt cggcaacatt gaatgacaaa   2640
gcaattgtag aagtaccaga atctaatgat gtaacattta actatggtaa taatccagat   2700
cacgggaata ctccaaagcc gaataagcca aatgaaaacg gcgatttgac attgaccaag   2760
acatgggttg atgctacagg tgcaccaatt ccggctggag ctgaagcaac gttcgatttg   2820
gttaatgctc agactggtaa agttgtacaa actgtaactt tgacaacaga caaaaataca   2880
gttactgtta acggattgga taaaaataca gaatataaat tcgttgaacg tagtataaaa   2940
gggtattcag cagattatca agaaatcact acagctggag aaattgctgt caagaactgg   3000
aaagacgaaa atccaaaacc acttgatcca acagagccaa aagttgttac atatggtaaa   3060
aagtttgtca aagttaatga taaagataat cgtttagctg gggcagaatt tgtaattgca   3120
aatgctgata atgctggtca atatttagca cgtaaagcag ataaagtgag tcaagaagag   3180
aagcagttgg ttgttacaac aaaggatgct ttagatagag cagttgctgc ttataacgct   3240
cttactgcac aacaacaaac tcagcaagaa aaagagaaag ttgacaaagc tcaagctgct   3300
tataatgctg ctgtgattgc tgccaacaat gcatttgaat gggtggcaga taaggacaat   3360
gaaaatgttg tgaaattagt ttctgatgca caaggtcgct ttgaaattac aggccttctt   3420
gcaggtacat attacttaga agaaacaaaa cagcctgctg gttatgcatt actaactagc   3480
cgtcagaaat ttgaagtcac tgcaacttct tattcagcga ctggacaagg cattgagtat   3540
actgctggtt caggtaaaga tgacgctaca aaagtagtca acaaaaaaat cactctcgag   3600
ggcagcggtg gcggtggcgc ggaacaaaaa actaagacac ttacagttca taaattattg   3660
atgacagatc aagagcttga cgcttggaat tctgatgcga ttactactgc aggttatgac   3720
ggttcgcaaa attttgaaca gttcaaacaa cttcaaggtg ttccacaagg agtaaccgaa   3780
atctctggtg ttgcattcga gttacagagt tatacgggtc ctcaaggaaa agaacaagaa   3840
aatttaacga atgatgcggt ttggactgcg gttaataaag gtgtgacgac tgaaacgggt   3900
gttaaatttg atactgaagt tttacaaggg acatatcgtc ttgtcgaagt acgtaaagaa   3960
tcgacttatg tcggtccaaa tggtaaagtt ttaacaggta tgaaagctgt tcctgcttta   4020
attattctgc cgcttgtaaa ccaaaatggt gttgtagaaa atgcacatgt ctatccaaag   4080
aattctgaag acaaacctac agcaacgaaa acatttgata ctgcagcagg tttcgtagat   4140
ccaggtgaaa aaggtttagc aattggcact aaggtaccgt atattgttac aacaactatt   4200
ccgaaaaact caactcttgc aacagctttc tggtcagatg aaatgacaga aggtctagat   4260
tataatggtg atgtagttgt taattataat ggtcaaccgc ttgataattc tcattacaca   4320
ttagaagcag gtcataatgg ctttatcttg aagttaaatg aaaaaggtct ggaagcaatc   4380
aacggtaaag atgcagaagc aacaattacg ttgaagtata ctgcaacttt aaatgctctt   4440
gctgttgctg atgtgccaga agcgaatgat gtaacattcc attatggaaa caacccaggt   4500
catggtaaca ctccaaaacc aaacaaacct aaaaacggtg aacttacaat tactaaaaca   4560
tgggctgatg ctaaagatgc tcctatagca ggtgtagaag taacttttga tttggtaaat   4620
gctcagacag gtgaggtcgt taaagtacct ggacatgaaa caggtattgt attgaatcaa   4680
acaaataatt ggacatttac tgctacaggt cttgataata atacagaata taaatttgtt   4740
gaacggacaa ttaagggata ttctgcagat taccaaacaa ttactgaaac aggaaaaatt   4800
gctgttaaaa actggaaaga tgaaaatcca gaaccaataa atcctgaaga gccacgtgta   4860
aaaacatatg gtaaaaaatt cgttaaggtt gaccaaaaag acgaacgctt aaaagaagca   4920
caattcgttg tgaagaatga gcaagggaaa tatcttgcac tcaaatctgc agcacaacaa   4980
gctgtaaatg agaaagctgc cgcagaagcg aaacaagcgc tagatgcagc gatagcagcc   5040
tatacaaatg ctgcagataa aaatgcagca caagctgtag tagatgctgc gcaaaaaaca   5100
tataatgaca attacagagc agctagattt ggctatgtag aagtagagag aaaagaagat   5160
gcgttagttc ttacttctaa cactgatggt caattccaaa tttcaggtct tgctgctgga   5220
agctacacgt tggaagaaac aaaagctcca gaaggctttg caaaacttgg agatgtgaag   5280
tttgaggttg gagcaggttc ttggaatcaa ggtgatttca attatttaaa agatgttcag   5340
aagaacgacg ctacaaaagt agtcaacaaa aaaatcacgc tcgagcacca ccaccaccac   5400
cac                                                                 5403

<210>   23
<211>   1312
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr0057 as found in the R6 strain

<400>   23
Met Lys His Glu Lys Gln Gln Arg Phe Ser Ile Arg Lys Tyr Ala Val 
1               5                   10                  15      

Gly Ala Ala Ser Val Leu Ile Gly Phe Ala Phe Gln Ala Gln Thr Val 
            20                  25                  30          

Ala Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr Ile 
        35                  40                  45              

His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu Glu 
    50                  55                  60                  

Thr Pro Lys Ala Glu Leu Gln Pro Glu Ala Pro Lys Thr Val Glu Thr 
65                  70                  75                  80  

Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu Glu 
                85                  90                  95      

Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu Val 
            100                 105                 110         

Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Glu Glu 
        115                 120                 125             

Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys Glu 
    130                 135                 140                 

Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp Glu 
145                 150                 155                 160 

Ala Lys Ala Glu Ala Asp Lys Pro Glu Thr Glu Thr Gly Lys Glu Arg 
                165                 170                 175     

Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser Ile 
            180                 185                 190         

Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile Ile 
        195                 200                 205             

Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val Gly 
    210                 215                 220                 

Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala Asn 
225                 230                 235                 240 

Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys Gly 
                245                 250                 255     

Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu Ser 
            260                 265                 270         

Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly Leu 
        275                 280                 285             

Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn Ala 
    290                 295                 300                 

Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly Lys 
305                 310                 315                 320 

Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala Phe 
                325                 330                 335     

Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys Thr 
            340                 345                 350         

Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr Asp 
        355                 360                 365             

Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn Glu 
    370                 375                 380                 

Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn Asp 
385                 390                 395                 400 

Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe Asn 
                405                 410                 415     

Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp Lys 
            420                 425                 430         

Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp Val 
        435                 440                 445             

Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn Thr 
    450                 455                 460                 

Asn Asp Ala Trp Cys Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln Gly 
465                 470                 475                 480 

Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro Ile 
                485                 490                 495     

Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly Gly 
            500                 505                 510         

Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro Ser 
        515                 520                 525             

His Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu Tyr 
    530                 535                 540                 

Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val Pro 
545                 550                 555                 560 

Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Ala Ala Val Lys Glu 
                565                 570                 575     

Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala Gln 
            580                 585                 590         

Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val Asn 
        595                 600                 605             

Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys Arg 
    610                 615                 620                 

Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala Gly 
625                 630                 635                 640 

Arg Lys Tyr Phe Thr Leu Asp Gln Leu Lys Arg Ile Val Asp Lys Ala 
                645                 650                 655     

Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp Gly 
            660                 665                 670         

Leu Arg Phe Leu Leu Asn Asp Met Thr Ile Thr Ala Asn Gly Lys Thr 
        675                 680                 685             

Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys Ala 
    690                 695                 700                 

Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val Thr 
705                 710                 715                 720 

Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro Ala 
                725                 730                 735     

Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu Lys 
            740                 745                 750         

Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys Thr 
        755                 760                 765             

Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala Leu 
    770                 775                 780                 

Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe Asn 
785                 790                 795                 800 

Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly Trp 
                805                 810                 815     

Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr Ala 
            820                 825                 830         

Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met Ala 
        835                 840                 845             

Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe Asp 
    850                 855                 860                 

Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr Asn 
865                 870                 875                 880 

Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu Asn 
                885                 890                 895     

Thr Asn Gly Asp Trp Tyr Tyr Val Ile Gly Asn His Lys Gln Asp Glu 
            900                 905                 910         

Ala Tyr Pro Leu Ser Lys Ala Val Glu Asn Ser Gly Lys Val Pro Phe 
        915                 920                 925             

Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr Val 
    930                 935                 940                 

Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr Lys 
945                 950                 955                 960 

Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn Lys 
                965                 970                 975     

Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala Lys 
            980                 985                 990         

Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala Leu 
        995                 1000                1005            

Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys Gln 
    1010                1015                1020                

Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln Gly 
1025                1030                1035                1040

Leu Lys Pro Ala Ala Thr His Ser Gly Ser Leu Asp Glu Asn Glu Val 
                1045                1050                1055    

Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu Glu 
            1060                1065                1070        

Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala Gly 
        1075                1080                1085            

Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His Tyr 
    1090                1095                1100                

Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu Asp 
1105                1110                1115                1120

Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly Ser 
                1125                1130                1135    

Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr Glu 
            1140                1145                1150        

Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr Thr 
        1155                1160                1165            

Val Thr Arg Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val Ile 
    1170                1175                1180                

Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser Thr 
1185                1190                1195                1200

Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val Ala 
                1205                1210                1215    

Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr His 
            1220                1225                1230        

Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro Lys 
        1235                1240                1245            

Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu Glu 
    1250                1255                1260                

Ser Lys Ala Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys Lys 
1265                1270                1275                1280

Leu Pro Glu Thr Gly Thr His Asp Ser Ala Glu Leu Val Val Ala Gly 
                1285                1290                1295    

Leu Met Ser Thr Leu Ala Ala Tyr Gly Leu Thr Lys Arg Lys Glu Asp 
            1300                1305                1310        


<210>   24
<211>   1062
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr0057 with N-terminal and C-terminal truncations

<400>   24
Leu His Leu Leu Val Gly Asn Asp Gly Leu Arg Phe Met Leu Asp Asp 
1               5                   10                  15      

Met Ser Ile Thr Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys 
            20                  25                  30          

Arg Ala Ile Glu Lys Gly Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly 
        35                  40                  45              

Asn His Leu Thr Glu Ser Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys 
    50                  55                  60                  

Asp Lys Gly Ile Gly Leu Ile Pro Thr Val Asn Ser Pro Gly His Met 
65                  70                  75                  80  

Asp Ala Ile Leu Asn Ala Met Lys Glu Leu Gly Ile Gln Asn Pro Asn 
                85                  90                  95      

Phe Ser Tyr Phe Gly Lys Lys Ser Ala Arg Thr Val Asp Leu Asp Asn 
            100                 105                 110         

Glu Gln Ala Val Ala Phe Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala 
        115                 120                 125             

Tyr Phe Ala Lys Lys Thr Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr 
    130                 135                 140                 

Ala Asn Asp Ala Thr Asp Ala Lys Gly Trp Ser Val Leu Gln Ala Asp 
145                 150                 155                 160 

Lys Tyr Tyr Pro Asn Glu Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe 
                165                 170                 175     

Ile Ala Tyr Ala Asn Asp Leu Ala Arg Ile Val Lys Ser His Gly Leu 
            180                 185                 190         

Lys Pro Met Ala Phe Asn Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser 
        195                 200                 205             

Phe Gly Ser Phe Asp Lys Asp Ile Ile Val Ser Met Trp Thr Gly Gly 
    210                 215                 220                 

Trp Gly Gly Tyr Asp Val Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly 
225                 230                 235                 240 

His Gln Ile Leu Asn Thr Asn Asp Ala Trp Cys Tyr Val Leu Gly Arg 
                245                 250                 255     

Asn Ala Asp Gly Gln Gly Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly 
            260                 265                 270         

Ile Lys Asn Thr Pro Ile Thr Ser Val Pro Lys Thr Glu Gly Ala Asp 
        275                 280                 285             

Ile Pro Ile Ile Gly Gly Met Val Ala Ala Trp Ala Asp Thr Pro Ser 
    290                 295                 300                 

Ala Arg Tyr Ser Pro Ser His Leu Phe Lys Leu Met Arg His Phe Ala 
305                 310                 315                 320 

Asn Ala Asn Ala Glu Tyr Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln 
                325                 330                 335     

Ala Leu Asn Glu Val Pro Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser 
            340                 345                 350         

Val Ala Ala Val Lys Glu Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser 
        355                 360                 365             

Asn Leu Ser Arg Ala Gln Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys 
    370                 375                 380                 

Leu Gln Glu Thr Val Asn Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys 
385                 390                 395                 400 

Glu Glu Glu Ala Lys Arg Glu Val Glu Lys Leu Ala Lys Asn Lys Val 
                405                 410                 415     

Ile Ser Ile Asp Ala Gly Arg Lys Tyr Phe Thr Leu Asp Gln Leu Lys 
            420                 425                 430         

Arg Ile Val Asp Lys Ala Ser Glu Leu Gly Tyr Ser Asp Val His Leu 
        435                 440                 445             

Leu Leu Gly Asn Asp Gly Leu Arg Phe Leu Leu Asn Asp Met Thr Ile 
    450                 455                 460                 

Thr Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile 
465                 470                 475                 480 

Ile Glu Gly Thr Lys Ala Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu 
                485                 490                 495     

Thr Gln Ala Glu Val Thr Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp 
            500                 505                 510         

Ile Gly Leu Ile Pro Ala Ile Asn Ser Pro Gly His Met Asp Ala Met 
        515                 520                 525             

Leu Val Ala Met Glu Lys Leu Gly Ile Lys Asn Pro Gln Ala His Phe 
    530                 535                 540                 

Asp Lys Val Ser Lys Thr Thr Met Asp Leu Lys Asn Glu Glu Ala Met 
545                 550                 555                 560 

Asn Phe Val Lys Ala Leu Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly 
                565                 570                 575     

Lys Thr Lys Ile Phe Asn Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala 
            580                 585                 590         

Thr Ser Ala Gln Gly Trp Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly 
        595                 600                 605             

Lys Phe Ala Glu Tyr Ala Asn Thr Leu Ala Ala Met Ala Lys Glu Arg 
    610                 615                 620                 

Gly Leu Gln Pro Met Ala Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys 
625                 630                 635                 640 

Asp Asp Val Gln Phe Asp Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys 
                645                 650                 655     

Gly Trp Trp Gly Tyr Asn Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys 
            660                 665                 670         

Gly Tyr Lys Phe Leu Asn Thr Asn Gly Asp Trp Tyr Tyr Val Ile Gly 
        675                 680                 685             

Asn His Lys Gln Asp Glu Ala Tyr Pro Leu Ser Lys Ala Val Glu Asn 
    690                 695                 700                 

Ser Gly Lys Val Pro Phe Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu 
705                 710                 715                 720 

Val Asp Leu Pro Thr Val Gly Ser Met Leu Ser Ile Trp Ala Asp Arg 
                725                 730                 735     

Pro Ser Ala Glu Tyr Lys Glu Glu Glu Ile Phe Glu Leu Met Thr Ala 
            740                 745                 750         

Phe Ala Asp His Asn Lys Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu 
        755                 760                 765             

Arg Glu Glu Leu Ala Lys Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys 
    770                 775                 780                 

Glu Ser Leu Glu Ala Leu Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn 
785                 790                 795                 800 

Leu Asn Arg Asn Lys Gln Ala Glu Leu Asp Thr Leu Val Ala Asn Leu 
                805                 810                 815     

Lys Ala Ala Leu Gln Gly Leu Lys Pro Ala Ala Thr His Ser Gly Ser 
            820                 825                 830         

Leu Asp Glu Asn Glu Val Ala Ala Asn Val Glu Thr Arg Pro Glu Leu 
        835                 840                 845             

Ile Thr Arg Thr Glu Glu Ile Pro Phe Glu Val Ile Lys Lys Glu Asn 
    850                 855                 860                 

Pro Asn Leu Pro Ala Gly Gln Glu Asn Ile Ile Thr Ala Gly Val Lys 
865                 870                 875                 880 

Gly Glu Arg Thr His Tyr Ile Ser Val Leu Thr Glu Asn Gly Lys Thr 
                885                 890                 895     

Thr Glu Thr Val Leu Asp Ser Gln Val Thr Lys Glu Val Ile Asn Gln 
            900                 905                 910         

Val Val Glu Val Gly Ser Pro Val Thr His Lys Gly Asp Glu Ser Gly 
        915                 920                 925             

Leu Ala Pro Thr Thr Glu Val Lys Pro Arg Leu Asp Ile Gln Glu Glu 
    930                 935                 940                 

Glu Ile Pro Phe Thr Thr Val Thr Arg Glu Asn Pro Leu Leu Leu Lys 
945                 950                 955                 960 

Gly Lys Thr Gln Val Ile Thr Lys Gly Val Asn Gly His Arg Ser Asn 
                965                 970                 975     

Phe Tyr Ser Val Ser Thr Ser Ala Asp Gly Lys Glu Val Lys Thr Leu 
            980                 985                 990         

Val Asn Ser Val Val Ala Gln Glu Ala Val Thr Gln Ile Val Glu Val 
        995                 1000                1005            

Gly Thr Met Val Thr His Val Gly Asp Glu Asn Gly Gln Ala Ala Ile 
    1010                1015                1020                

Ala Glu Glu Lys Pro Lys Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser 
1025                1030                1035                1040

Thr Ala Pro Ala Glu Glu Ser Lys Ala Leu Pro Gln Asp Pro Ala Pro 
                1045                1050                1055    

Val Val Thr Glu Lys Lys 
            1060        

<210>   25
<211>   2228
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr0565 as found in the R6 strain

<400>   25
Met Gly Lys Gly His Trp Asn Arg Lys Arg Val Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Phe Ala Val Gly Ala Cys Ser Val Met Ile Gly Thr Cys Ala Val Leu 
            20                  25                  30          

Leu Gly Gly Asn Ile Ala Gly Glu Ser Val Val Tyr Ala Asp Glu Thr 
        35                  40                  45              

Leu Ile Thr His Thr Ala Glu Lys Pro Lys Glu Glu Lys Met Ile Val 
    50                  55                  60                  

Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr Lys Asn Val Val Glu Arg 
65                  70                  75                  80  

Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu Ala Ile Ala Ser Glu Lys 
                85                  90                  95      

Lys Glu Asp Glu Ala Val Thr Pro Lys Glu Glu Lys Val Ser Ala Lys 
            100                 105                 110         

Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser Gln Ala Ser Ser Gln Glu 
        115                 120                 125             

Lys Pro Leu Lys Glu Asp Ala Lys Ala Val Thr Asn Glu Glu Val Asn 
    130                 135                 140                 

Gln Met Ile Glu Asn Arg Lys Val Asp Phe Asn Gln Asn Trp Tyr Phe 
145                 150                 155                 160 

Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile Lys Pro Asp Ala Asp Val 
                165                 170                 175     

Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr Asp Trp Ser Ile Phe Asn 
            180                 185                 190         

Asp Phe Asp His Glu Ser Pro Ala Gln Asn Glu Gly Gly Gln Leu Asn 
        195                 200                 205             

Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe Lys Leu Asp Glu Lys Asp 
    210                 215                 220                 

Leu Lys Lys Asn Val Arg Leu Thr Phe Asp Gly Val Tyr Met Asp Ser 
225                 230                 235                 240 

Gln Val Tyr Val Asn Gly Gln Leu Val Gly His Tyr Pro Asn Gly Tyr 
                245                 250                 255     

Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr Leu Tyr Lys Asp Gly Arg 
            260                 265                 270         

Glu Asn Val Ile Ala Val His Ala Val Asn Lys Gln Pro Ser Ser Arg 
        275                 280                 285             

Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu Gln Val Thr 
    290                 295                 300                 

Asp Lys Val His Val Glu Lys Asn Gly Thr Thr Ile Leu Thr Pro Lys 
305                 310                 315                 320 

Leu Glu Glu Gln Gln His Gly Lys Val Glu Thr His Val Thr Ser Lys 
                325                 330                 335     

Ile Val Asn Thr Asp Asp Lys Asp His Glu Leu Val Ala Glu Tyr Gln 
            340                 345                 350         

Ile Val Glu Arg Gly Gly His Ala Val Thr Gly Leu Val Arg Thr Ala 
        355                 360                 365             

Ser Arg Thr Leu Lys Ala His Glu Ser Thr Ser Leu Asp Ala Ile Leu 
    370                 375                 380                 

Glu Val Glu Arg Pro Lys Leu Trp Thr Val Leu Asn Asp Lys Pro Ala 
385                 390                 395                 400 

Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg Asp Gly Gln Leu Val Asp 
                405                 410                 415     

Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr Tyr His Trp Thr Pro Asn 
            420                 425                 430         

Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile Lys Phe His Gly Val Ser 
        435                 440                 445             

Leu His His Asp His Gly Ala Leu Gly Ala Glu Glu Asn Tyr Lys Ala 
    450                 455                 460                 

Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu Met Gly Val Asn Ser Ile 
465                 470                 475                 480 

Arg Thr Thr His Asn Pro Ala Ser Glu Gln Thr Leu Gln Ile Ala Ala 
                485                 490                 495     

Glu Leu Gly Leu Leu Val Gln Glu Glu Ala Phe Asp Thr Trp Tyr Gly 
            500                 505                 510         

Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe Phe Glu Lys Asp Ala Thr 
        515                 520                 525             

His Pro Glu Ala Arg Lys Gly Glu Lys Trp Ser Asp Phe Asp Leu Arg 
    530                 535                 540                 

Thr Met Val Glu Arg Gly Lys Asn Asn Pro Ala Ile Phe Met Trp Ser 
545                 550                 555                 560 

Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly Asp Ala His Ser Leu Ala 
                565                 570                 575     

Thr Val Lys Arg Leu Val Lys Val Ile Lys Asp Val Asp Lys Thr Arg 
            580                 585                 590         

Tyr Val Thr Met Gly Ala Asp Lys Phe Arg Phe Gly Asn Gly Ser Gly 
        595                 600                 605             

Gly His Glu Lys Ile Ala Asp Glu Leu Asp Ala Val Gly Phe Asn Tyr 
    610                 615                 620                 

Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala Lys His Pro Lys Trp Leu 
625                 630                 635                 640 

Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr Arg Thr Arg Gly Ser Tyr 
                645                 650                 655     

Tyr Arg Pro Glu Arg Glu Leu Lys His Ser Asn Gly Pro Glu Arg Asn 
            660                 665                 670         

Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg Val Gly Trp Gly Lys Thr 
        675                 680                 685             

Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp Asn Ala Gly Tyr Ala Gly 
    690                 695                 700                 

Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile Gly Glu Pro Thr Pro Trp 
705                 710                 715                 720 

His Asn Gln Asn Gln Thr Pro Val Lys Ser Ser Tyr Phe Gly Ile Val 
                725                 730                 735     

Asp Thr Ala Gly Ile Pro Lys His Asp Phe Tyr Leu Tyr Gln Ser Gln 
            740                 745                 750         

Trp Val Ser Val Lys Lys Lys Pro Met Val His Leu Leu Pro His Trp 
        755                 760                 765             

Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys Val Ala Asp Ser Glu Gly 
    770                 775                 780                 

Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala Ser Ser Val Glu Leu Phe 
785                 790                 795                 800 

Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr Phe Asn Lys Lys Gln Thr 
                805                 810                 815     

Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala Asn Ala Asn Glu Leu Tyr 
            820                 825                 830         

Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly Thr Leu Glu Ala Ile Ala 
        835                 840                 845             

Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg Asp Lys Ile Thr Thr Ala 
    850                 855                 860                 

Gly Lys Pro Ala Ala Val Arg Leu Ile Lys Glu Asp His Ala Ile Ala 
865                 870                 875                 880 

Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr Tyr Glu Ile Val Asp Ser 
                885                 890                 895     

Gln Gly Asn Val Val Pro Thr Ala Asn Asn Leu Val Arg Phe Gln Leu 
            900                 905                 910         

His Gly Gln Gly Gln Leu Val Gly Val Asp Asn Gly Glu Gln Ala Ser 
        915                 920                 925             

Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly Ser Trp Ile Arg Lys Ala 
    930                 935                 940                 

Phe Asn Gly Lys Gly Val Ala Ile Val Lys Ser Thr Glu Gln Ala Gly 
945                 950                 955                 960 

Lys Phe Thr Leu Thr Ala His Ser Asp Leu Leu Lys Ser Asn Gln Val 
                965                 970                 975     

Thr Val Phe Thr Gly Lys Lys Glu Gly Gln Glu Lys Thr Val Leu Gly 
            980                 985                 990         

Thr Glu Val Pro Lys Val Gln Thr Ile Ile Gly Glu Ala Pro Glu Met 
        995                 1000                1005            

Pro Thr Thr Val Pro Phe Val Tyr Ser Asp Gly Ser Arg Ala Glu Arg 
    1010                1015                1020                

Pro Val Thr Trp Ser Leu Val Asp Val Ser Lys Pro Gly Ile Val Thr 
1025                1030                1035                1040

Val Lys Gly Met Ala Asp Gly Arg Glu Val Glu Ala Arg Val Glu Val 
                1045                1050                1055    

Ile Ala Leu Lys Ser Glu Leu Pro Val Val Lys Arg Ile Ala Pro Asn 
            1060                1065                1070        

Thr Asn Leu Asn Ser Val Asp Lys Ser Val Ser Tyr Val Leu Thr Asp 
        1075                1080                1085            

Gly Ser Val Gln Glu Tyr Glu Val Asp Lys Trp Glu Ile Ala Glu Glu 
    1090                1095                1100                

Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser Arg Ile Gln Ala Thr Gly 
1105                1110                1115                1120

Tyr Leu Glu Gly Gln Pro Ile His Ala Thr Leu Val Val Glu Glu Gly 
                1125                1130                1135    

Asn Pro Ala Ala Pro Val Val Pro Thr Val Thr Val Gly Gly Glu Ala 
            1140                1145                1150        

Val Thr Gly Leu Thr Ser Arg Gln Pro Met Gln Tyr Arg Thr Leu Ser 
        1155                1160                1165            

Tyr Gly Ala Gln Leu Pro Glu Val Thr Ala Ser Ala Glu Asn Ala Asp 
    1170                1175                1180                

Val Thr Val Leu Gln Ala Ser Ala Ala Asn Gly Met Arg Ala Ser Ile 
1185                1190                1195                1200

Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu Gln Thr Tyr Ala Ile Gln 
                1205                1210                1215    

Phe Leu Glu Glu Ala Pro Lys Ile Ala His Leu Ser Leu Gln Val Glu 
            1220                1225                1230        

Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr Val Lys Leu Ser Val Arg 
        1235                1240                1245            

Ala His Tyr Gln Asp Gly Thr Gln Ala Val Leu Pro Ala Asp Lys Val 
    1250                1255                1260                

Thr Phe Ser Thr Ser Gly Glu Gly Glu Val Ala Ile Arg Lys Gly Met 
1265                1270                1275                1280

Leu Glu Leu His Lys Pro Gly Ala Val Thr Leu Asn Ala Glu Tyr Glu 
                1285                1290                1295    

Gly Ala Lys Gly Gln Val Glu Leu Thr Ile Gln Ala Asn Thr Glu Lys 
            1300                1305                1310        

Lys Ile Ala Gln Ser Ile Arg Pro Val Asn Val Val Thr Asp Leu His 
        1315                1320                1325            

Gln Glu Pro Ser Leu Pro Ala Thr Val Thr Val Glu Tyr Asp Lys Gly 
    1330                1335                1340                

Phe Pro Lys Thr His Lys Val Thr Trp Gln Ala Ile Pro Lys Glu Lys 
1345                1350                1355                1360

Leu Asp Ser Tyr Gln Ile Phe Glu Val Leu Gly Lys Val Glu Gly Ile 
                1365                1370                1375    

Asp Leu Glu Ala Arg Ala Lys Val Ser Val Glu Gly Ile Val Ser Val 
            1380                1385                1390        

Glu Glu Val Ser Val Thr Thr Pro Ile Ala Glu Ala Pro Gln Leu Pro 
        1395                1400                1405            

Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly His Val Ser Ser Ala Lys 
    1410                1415                1420                

Val Ala Trp Asp Ala Ile Arg Pro Glu Gln Tyr Ala Lys Glu Gly Val 
1425                1430                1435                1440

Phe Thr Val Asn Gly Arg Leu Glu Gly Thr Gln Leu Thr Thr Lys Leu 
                1445                1450                1455    

His Val Arg Val Ser Ala Gln Thr Glu Gln Gly Ala Asn Ile Ser Asp 
            1460                1465                1470        

Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala Phe Ala Ser Asp Ser Asn 
        1475                1480                1485            

Pro Ser Asp Pro Val Ser Asn Val Asn Asp Lys Leu Ile Ser Tyr Asn 
    1490                1495                1500                

Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp Asn Arg Ser Asn Pro Glu 
1505                1510                1515                1520

Ala Ser Val Gly Val Leu Phe Gly Asp Ser Gly Ile Leu Ser Lys Arg 
                1525                1530                1535    

Ser Val Asp Asn Leu Ser Val Gly Phe His Glu Asp His Gly Val Gly 
            1540                1545                1550        

Ala Pro Lys Ser Tyr Val Ile Glu Tyr Tyr Val Gly Lys Thr Val Pro 
        1555                1560                1565            

Thr Ala Pro Lys Asn Pro Ser Phe Val Gly Asn Glu Asp His Val Phe 
    1570                1575                1580                

Asn Asp Ser Ala Asn Trp Lys Pro Val Thr Asn Leu Lys Ala Pro Ala 
1585                1590                1595                1600

Gln Leu Lys Ala Gly Glu Met Asn His Phe Ser Phe Asp Lys Val Glu 
                1605                1610                1615    

Thr Tyr Ala Ile Arg Ile Arg Met Val Lys Ala Asp Asn Lys Arg Gly 
            1620                1625                1630        

Thr Ser Ile Thr Glu Val Gln Ile Phe Ala Lys Gln Val Ala Ala Ala 
        1635                1640                1645            

Lys Gln Gly Gln Thr Arg Ile Gln Val Asp Gly Lys Asp Leu Ala Asn 
    1650                1655                1660                

Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu Glu Ser Val Asp Gly Lys 
1665                1670                1675                1680

Val Pro Ala Val Thr Ala Asn Val Ser Asn Asn Gly Leu Ala Thr Val 
                1685                1690                1695    

Val Pro Ser Val Arg Glu Gly Glu Pro Val Arg Val Ile Ala Lys Ala 
            1700                1705                1710        

Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg Leu His Phe Thr Lys Asp 
        1715                1720                1725            

Lys Asn Leu Leu Ser His Lys Pro Val Ala Ala Val Lys Gln Ala Arg 
    1730                1735                1740                

Leu Leu Gln Val Gly Gln Ala Leu Glu Leu Pro Thr Lys Val Pro Val 
1745                1750                1755                1760

Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr Lys Asp Leu Thr Val Glu 
                1765                1770                1775    

Trp Glu Glu Val Pro Ala Glu Asn Leu Thr Lys Ala Gly Gln Phe Thr 
            1780                1785                1790        

Val Arg Gly Arg Val Leu Gly Ser Asn Leu Val Ala Glu Val Thr Val 
        1795                1800                1805            

Arg Val Thr Asp Lys Leu Gly Glu Thr Leu Ser Asp Asn Pro Asn Tyr 
    1810                1815                1820                

Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser Ala Thr Asn Asp Ile Asp 
1825                1830                1835                1840

Lys Asn Ser His Asp Arg Val Asp Tyr Leu Asn Asp Gly Asp His Ser 
                1845                1850                1855    

Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro Thr Pro Ser Ser Asn Pro 
            1860                1865                1870        

Glu Val Ser Ala Gly Val Ile Phe Arg Glu Asn Gly Lys Ile Val Glu 
        1875                1880                1885            

Arg Thr Val Ala Gln Ala Lys Leu His Phe Phe Ala Asp Ser Gly Thr 
    1890                1895                1900                

Asp Ala Pro Ser Lys Leu Val Leu Glu Arg Tyr Val Gly Pro Gly Phe 
1905                1910                1915                1920

Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln Ala Tyr Glu Ser Gly His 
                1925                1930                1935    

Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala Val Pro Tyr Arg Ala Asp 
            1940                1945                1950        

Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn Val Thr Phe Lys Ala Val 
        1955                1960                1965            

Lys Ala Lys Val Met Arg Trp Arg Met Glu Arg Lys Ala Asp Lys Ser 
    1970                1975                1980                

Gly Val Ala Met Ile Glu Met Thr Phe Leu Ala Pro Ser Glu Leu Pro 
1985                1990                1995                2000

Gln Glu Ser Thr Gln Ser Lys Ile Leu Val Asp Gly Lys Glu Leu Ala 
                2005                2010                2015    

Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln Ile Thr Tyr Lys Gly Gln 
            2020                2025                2030        

Arg Pro Lys Val Ser Val Glu Glu Asn Asn Gln Val Ala Ser Thr Val 
        2035                2040                2045            

Val Asp Ser Gly Glu Asp Ser Leu Pro Val Leu Val Arg Leu Val Ser 
    2050                2055                2060                

Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg Ile Gln Leu Thr Lys Glu 
2065                2070                2075                2080

Lys Pro Val Ser Ala Val Gln Glu Asp Leu Pro Lys Leu Glu Phe Val 
                2085                2090                2095    

Glu Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu 
            2100                2105                2110        

Tyr Leu Gly Glu Thr Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu 
        2115                2120                2125            

Arg Ile Phe Thr Val Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu 
    2130                2135                2140                

Arg Glu Val Val Glu Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr 
2145                2150                2155                2160

Lys Pro Val Ala Gln Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala 
                2165                2170                2175    

Asp Thr Lys Pro Ile Asp Ser Ser Glu Ala Asp Gln Thr Asn Lys Ala 
            2180                2185                2190        

Gln Leu Pro Asn Thr Gly Ser Ala Ala Ser Gln Ala Ala Val Ala Ala 
        2195                2200                2205            

Gly Leu Ala Leu Leu Gly Leu Ser Ala Gly Leu Val Val Thr Lys Gly 
    2210                2215                2220                

Lys Lys Glu Asp 
2225            

<210>   26
<211>   247
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr1098 as found in the R6 strain

<400>   26
Met Ser Gln Lys Asn Asn Lys Lys Lys Asn Lys Arg Lys Asn Leu Leu 
1               5                   10                  15      

Thr Asn Ile Leu Ala Gly Phe Leu Ile Leu Leu Ser Leu Ala Leu Ile 
            20                  25                  30          

Phe Asn Thr Gln Ile Arg Asn Ile Phe Ile Val Trp Asn Thr Asn Lys 
        35                  40                  45              

Tyr Gln Val Ser Gln Val Ser Lys Glu Lys Leu Glu Glu Asn Gln Asp 
    50                  55                  60                  

Thr Glu Gly Asn Phe Asp Phe Asp Ser Val Lys Ala Ile Ser Ser Glu 
65                  70                  75                  80  

Ala Val Leu Thr Ser Gln Trp Asp Ala Gln Lys Leu Pro Val Ile Gly 
                85                  90                  95      

Gly Ile Ala Ile Pro Glu Leu Glu Met Asn Leu Pro Ile Phe Lys Gly 
            100                 105                 110         

Leu Asp Asn Val Asn Leu Phe Tyr Gly Ala Gly Thr Met Lys Arg Glu 
        115                 120                 125             

Gln Val Met Gly Glu Gly Asn Tyr Ser Leu Ala Ser His His Ile Phe 
    130                 135                 140                 

Gly Val Asp Asn Ala Asn Lys Met Leu Phe Ser Pro Leu Asp Asn Ala 
145                 150                 155                 160 

Lys Asn Gly Met Lys Ile Tyr Leu Thr Asp Lys Asn Lys Val Tyr Thr 
                165                 170                 175     

Tyr Glu Ile Arg Glu Val Lys Arg Val Thr Pro Asp Arg Val Asp Glu 
            180                 185                 190         

Val Asp Asp Arg Asp Gly Val Asn Glu Ile Thr Leu Val Thr Cys Glu 
        195                 200                 205             

Asp Leu Ala Ala Thr Glu Arg Ile Ile Val Lys Gly Asp Leu Lys Glu 
    210                 215                 220                 

Thr Lys Asp Tyr Ser Gln Thr Ser Asp Glu Ile Leu Thr Ala Phe Asn 
225                 230                 235                 240 

Gln Pro Tyr Lys Gln Phe Tyr 
                245         

<210>   27
<211>   1062
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   a variant of SEQ ID NO: 24 based on a different wild-type strain

<400>   27
Leu His Leu Leu Val Gly Asn Asp Gly Leu Arg Phe Met Leu Asp Asp 
1               5                   10                  15      

Met Ser Ile Thr Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys 
            20                  25                  30          

Arg Ala Ile Glu Lys Gly Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly 
        35                  40                  45              

Asn His Leu Thr Glu Ser Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys 
    50                  55                  60                  

Asp Lys Gly Ile Gly Leu Ile Pro Thr Val Asn Ser Pro Gly His Met 
65                  70                  75                  80  

Asp Ala Ile Leu Asn Ala Met Lys Glu Leu Gly Ile Gln Asn Pro Asn 
                85                  90                  95      

Phe Ser Tyr Phe Gly Lys Lys Ser Ala Arg Thr Val Asp Leu Asp Asn 
            100                 105                 110         

Glu Gln Ala Val Ala Phe Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala 
        115                 120                 125             

Tyr Phe Ala Lys Lys Thr Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr 
    130                 135                 140                 

Ala Asn Asp Ala Thr Asp Ala Lys Gly Trp Ser Val Leu Gln Ala Asp 
145                 150                 155                 160 

Lys Tyr Tyr Pro Asn Glu Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe 
                165                 170                 175     

Ile Ala Tyr Ala Asn Asp Leu Ala Arg Ile Val Lys Ser His Gly Leu 
            180                 185                 190         

Lys Pro Met Ala Phe Asn Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser 
        195                 200                 205             

Phe Gly Ser Phe Asp Lys Asp Ile Ile Val Ser Met Trp Thr Gly Gly 
    210                 215                 220                 

Trp Gly Gly Tyr Asp Val Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly 
225                 230                 235                 240 

His Gln Ile Leu Asn Thr Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg 
                245                 250                 255     

Asn Ala Asp Gly Gln Gly Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly 
            260                 265                 270         

Ile Lys Asn Thr Pro Ile Thr Ser Val Pro Lys Thr Glu Gly Ala Asp 
        275                 280                 285             

Ile Pro Ile Ile Gly Gly Met Val Ala Ala Trp Ala Asp Thr Pro Ser 
    290                 295                 300                 

Ala Arg Tyr Ser Pro Ser Arg Leu Phe Lys Leu Met Arg His Phe Ala 
305                 310                 315                 320 

Asn Ala Asn Ala Glu Tyr Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln 
                325                 330                 335     

Ala Leu Asn Glu Val Pro Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser 
            340                 345                 350         

Val Thr Ala Val Lys Glu Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser 
        355                 360                 365             

Asn Leu Ser Arg Ala Gln Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys 
    370                 375                 380                 

Leu Gln Glu Thr Val Asn Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys 
385                 390                 395                 400 

Glu Glu Glu Ala Lys Arg Glu Val Glu Lys Leu Ala Lys Asn Lys Val 
                405                 410                 415     

Ile Ser Ile Asp Ala Gly Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys 
            420                 425                 430         

Arg Ile Val Asp Lys Ala Ser Glu Leu Gly Tyr Ser Asp Val His Leu 
        435                 440                 445             

Leu Leu Gly Asn Asp Gly Leu Arg Phe Leu Leu Asp Asp Met Thr Ile 
    450                 455                 460                 

Thr Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile 
465                 470                 475                 480 

Ile Glu Gly Thr Lys Ala Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu 
                485                 490                 495     

Thr Gln Ala Glu Val Thr Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp 
            500                 505                 510         

Ile Gly Leu Ile Pro Ala Ile Asn Ser Pro Gly His Met Asp Ala Met 
        515                 520                 525             

Leu Val Ala Met Glu Lys Leu Gly Ile Lys Asn Pro Gln Ala His Phe 
    530                 535                 540                 

Asp Lys Val Ser Lys Thr Thr Met Asp Leu Lys Asn Glu Glu Ala Met 
545                 550                 555                 560 

Asn Phe Val Lys Ala Leu Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly 
                565                 570                 575     

Lys Thr Lys Ile Phe Asn Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala 
            580                 585                 590         

Thr Ser Ala Gln Gly Trp Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly 
        595                 600                 605             

Lys Phe Ala Glu Tyr Ala Asn Thr Leu Ala Ala Met Ala Lys Glu Arg 
    610                 615                 620                 

Gly Leu Gln Pro Met Ala Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys 
625                 630                 635                 640 

Asp Asp Val Gln Phe Asp Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys 
                645                 650                 655     

Gly Trp Trp Gly Tyr Asn Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys 
            660                 665                 670         

Gly Tyr Lys Phe Leu Asn Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly 
        675                 680                 685             

Gln Lys Pro Glu Asp Gly Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn 
    690                 695                 700                 

Thr Gly Lys Thr Pro Phe Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu 
705                 710                 715                 720 

Val Asp Leu Pro Thr Val Gly Ser Met Leu Ser Ile Trp Ala Asp Arg 
                725                 730                 735     

Pro Ser Ala Glu Tyr Lys Glu Glu Glu Ile Phe Glu Leu Met Thr Ala 
            740                 745                 750         

Phe Ala Asp His Asn Lys Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu 
        755                 760                 765             

Arg Glu Glu Leu Ala Lys Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys 
    770                 775                 780                 

Glu Ser Leu Glu Ala Leu Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn 
785                 790                 795                 800 

Leu Asn Arg Asn Lys Gln Ala Glu Leu Asp Thr Leu Val Ala Asn Leu 
                805                 810                 815     

Lys Ala Ala Leu Gln Gly Leu Lys Pro Ala Val Thr His Ser Gly Ser 
            820                 825                 830         

Leu Asp Glu Asn Glu Val Ala Ala Asn Val Glu Thr Arg Pro Glu Leu 
        835                 840                 845             

Ile Thr Arg Thr Glu Glu Ile Pro Phe Glu Val Ile Lys Lys Glu Asn 
    850                 855                 860                 

Pro Asn Leu Pro Ala Gly Gln Glu Asn Ile Ile Thr Ala Gly Val Lys 
865                 870                 875                 880 

Gly Glu Arg Thr His Tyr Ile Ser Val Leu Thr Glu Asn Gly Lys Thr 
                885                 890                 895     

Thr Glu Thr Val Leu Asp Ser Gln Val Thr Lys Glu Val Ile Asn Gln 
            900                 905                 910         

Val Val Glu Val Gly Ala Pro Val Thr His Lys Gly Asp Glu Ser Gly 
        915                 920                 925             

Leu Ala Pro Thr Thr Glu Val Lys Pro Arg Leu Asp Ile Gln Glu Glu 
    930                 935                 940                 

Glu Ile Pro Phe Thr Thr Val Thr Cys Glu Asn Pro Leu Leu Leu Lys 
945                 950                 955                 960 

Gly Lys Thr Gln Val Ile Thr Lys Gly Val Asn Gly His Arg Ser Asn 
                965                 970                 975     

Phe Tyr Ser Val Ser Thr Ser Ala Asp Gly Lys Glu Val Lys Thr Leu 
            980                 985                 990         

Val Asn Ser Val Val Ala Gln Glu Ala Val Thr Gln Ile Val Glu Val 
        995                 1000                1005            

Gly Thr Met Val Thr His Val Gly Asp Glu Asn Gly Gln Ala Ala Ile 
    1010                1015                1020                

Ala Glu Glu Lys Pro Lys Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser 
1025                1030                1035                1040

Thr Ala Pro Ala Glu Glu Ser Lys Val Leu Pro Gln Asp Pro Ala Pro 
                1045                1050                1055    

Val Val Thr Glu Lys Lys 
            1060        

<210>   28
<211>   128
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr1416 as found in the R6 strain

<400>   28
Met Glu Lys Asp Met Asn Leu Lys Arg Glu Gln Glu Phe Val Ser Gln 
1               5                   10                  15      

Tyr His Phe Asp Ala Arg Asn Phe Glu Trp Glu Asn Glu Asn Gly Ala 
            20                  25                  30          

Pro Glu Thr Lys Val Asp Val Asn Phe Gln Leu Leu Gln His Asp Gln 
        35                  40                  45              

Glu Asn Gln Val Thr Ser Leu Ile Val Ile Leu Ser Phe Met Ile Val 
    50                  55                  60                  

Phe Asp Lys Phe Val Ile Ser Gly Thr Ile Ser Gln Val Asn His Ile 
65                  70                  75                  80  

Asp Gly Arg Ile Val Asn Glu Pro Asn Glu Leu Asn Gln Glu Glu Val 
                85                  90                  95      

Glu Thr Leu Ala Arg Pro Cys Leu Asn Met Leu Asn Arg Leu Thr Tyr 
            100                 105                 110         

Glu Val Thr Glu Ile Ala Leu Asp Leu Pro Gly Ile Asn Leu Glu Phe 
        115                 120                 125             


<210>   29
<211>   259
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr1418 as found in the R6 strain

<400>   29
Met Lys Lys Asn Ser Leu Tyr Ile Ile Ser Ser Leu Phe Phe Ala Cys 
1               5                   10                  15      

Val Leu Phe Val Tyr Ala Thr Ala Thr Asn Phe Gln Asn Ser Thr Ser 
            20                  25                  30          

Ala Arg Gln Val Lys Thr Glu Thr Tyr Thr Asn Thr Val Thr Asn Val 
        35                  40                  45              

Pro Ile Asp Ile Arg Tyr Asn Ser Asp Lys Tyr Phe Ile Ser Gly Phe 
    50                  55                  60                  

Ala Ser Glu Val Ser Val Val Leu Thr Gly Ala Asn Arg Leu Ser Leu 
65                  70                  75                  80  

Ala Ser Glu Met Gln Glu Ser Thr Arg Lys Phe Lys Val Thr Ala Asp 
                85                  90                  95      

Leu Thr Asp Ala Gly Val Gly Thr Ile Glu Val Pro Leu Ser Ile Glu 
            100                 105                 110         

Asp Leu Pro Asn Gly Leu Thr Ala Val Ala Thr Pro Gln Lys Ile Thr 
        115                 120                 125             

Val Lys Ile Gly Lys Lys Ala Gln Lys Asp Lys Val Lys Ile Val Pro 
    130                 135                 140                 

Glu Ile Asp Pro Ser Gln Ile Asp Ser Arg Val Gln Ile Glu Asn Val 
145                 150                 155                 160 

Met Val Ser Asp Lys Glu Val Ser Ile Thr Ser Asp Gln Glu Thr Leu 
                165                 170                 175     

Asp Arg Ile Asp Lys Ile Ile Ala Val Leu Pro Thr Ser Glu Arg Ile 
            180                 185                 190         

Thr Gly Asn Tyr Ser Gly Ser Val Pro Leu Gln Ala Ile Asp Arg Asn 
        195                 200                 205             

Gly Val Val Leu Pro Ala Val Ile Thr Pro Phe Asp Thr Ile Met Lys 
    210                 215                 220                 

Val Thr Thr Lys Pro Val Ala Pro Ser Ser Ser Thr Ser Asn Ser Ser 
225                 230                 235                 240 

Thr Ser Ser Ser Ser Glu Thr Ser Ser Ser Thr Lys Ala Thr Ser Ser 
                245                 250                 255     

Lys Thr Asn 
            

<210>   30
<211>   721
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr0867 as found in the R6 strain

<400>   30
Met Asn Leu Gly Glu Phe Trp Tyr Asn Lys Ile Asn Lys Asn Arg Gly 
1               5                   10                  15      

Arg Arg Leu Met Lys Lys Val Arg Phe Ile Phe Leu Ala Leu Leu Phe 
            20                  25                  30          

Phe Leu Ala Ser Pro Glu Gly Ala Met Ala Ser Asp Gly Thr Trp Gln 
        35                  40                  45              

Gly Lys Gln Tyr Leu Lys Glu Asp Gly Ser Gln Ala Ala Asn Glu Trp 
    50                  55                  60                  

Val Phe Asp Thr His Tyr Gln Ser Trp Phe Tyr Ile Lys Ala Asp Ala 
65                  70                  75                  80  

Asn Tyr Ala Glu Asn Glu Trp Leu Lys Gln Gly Asp Asp Tyr Phe Tyr 
                85                  90                  95      

Leu Lys Ser Gly Gly Tyr Met Ala Lys Ser Glu Trp Val Glu Asp Lys 
            100                 105                 110         

Gly Ala Phe Tyr Tyr Leu Asp Gln Asp Gly Lys Met Lys Arg Asn Ala 
        115                 120                 125             

Trp Val Gly Thr Ser Tyr Val Gly Ala Thr Gly Ala Lys Val Ile Glu 
    130                 135                 140                 

Asp Trp Val Tyr Asp Ser Gln Tyr Asp Ala Trp Phe Tyr Ile Lys Ala 
145                 150                 155                 160 

Asp Gly Gln His Ala Glu Lys Glu Trp Leu Gln Ile Lys Gly Lys Asp 
                165                 170                 175     

Tyr Tyr Phe Lys Ser Gly Gly Tyr Leu Leu Thr Ser Gln Trp Ile Asn 
            180                 185                 190         

Gln Ala Tyr Val Asn Ala Ser Gly Ala Lys Val Gln Gln Gly Trp Leu 
        195                 200                 205             

Phe Asp Lys Gln Tyr Gln Ser Trp Phe Tyr Ile Lys Glu Asn Gly Asn 
    210                 215                 220                 

Tyr Ala Asp Lys Glu Trp Ile Phe Glu Asn Gly His Tyr Tyr Tyr Leu 
225                 230                 235                 240 

Lys Ser Gly Gly Tyr Met Ala Ala Asn Glu Trp Ile Trp Asp Lys Glu 
                245                 250                 255     

Ser Trp Phe Tyr Leu Lys Phe Asp Gly Lys Ile Ala Glu Lys Glu Trp 
            260                 265                 270         

Val Tyr Asp Ser His Ser Gln Ala Trp Tyr Tyr Phe Lys Ser Gly Gly 
        275                 280                 285             

Tyr Met Ala Ala Asn Glu Trp Ile Trp Asp Lys Glu Ser Trp Phe Tyr 
    290                 295                 300                 

Leu Lys Phe Asp Gly Lys Met Ala Glu Lys Glu Trp Val Tyr Asp Ser 
305                 310                 315                 320 

His Ser Gln Ala Trp Tyr Tyr Phe Lys Ser Gly Gly Tyr Met Thr Ala 
                325                 330                 335     

Asn Glu Trp Ile Trp Asp Lys Glu Ser Trp Phe Tyr Leu Lys Ser Asp 
            340                 345                 350         

Gly Lys Ile Ala Glu Lys Glu Trp Val Tyr Asp Ser His Ser Gln Ala 
        355                 360                 365             

Trp Tyr Tyr Phe Lys Ser Gly Gly Tyr Met Thr Ala Asn Glu Trp Ile 
    370                 375                 380                 

Trp Asp Lys Glu Ser Trp Phe Tyr Leu Lys Ser Asp Gly Lys Met Ala 
385                 390                 395                 400 

Glu Lys Glu Trp Val Tyr Asp Ser His Ser Gln Ala Trp Tyr Tyr Phe 
                405                 410                 415     

Lys Ser Gly Gly Tyr Met Ala Lys Asn Glu Thr Val Asp Gly Tyr Gln 
            420                 425                 430         

Leu Gly Ser Asp Gly Lys Trp Leu Gly Gly Lys Ala Thr Asn Lys Asn 
        435                 440                 445             

Ala Ala Tyr Tyr Gln Val Val Pro Val Thr Ala Asn Val Tyr Asp Ser 
    450                 455                 460                 

Asp Gly Glu Lys Leu Ser Tyr Ile Ser Gln Gly Ser Val Val Trp Leu 
465                 470                 475                 480 

Asp Lys Asp Arg Lys Ser Asp Asp Lys Arg Leu Ala Ile Thr Ile Ser 
                485                 490                 495     

Gly Leu Ser Gly Tyr Met Lys Thr Glu Asp Leu Gln Ala Leu Asp Ala 
            500                 505                 510         

Ser Lys Asp Phe Ile Pro Tyr Tyr Glu Ser Asp Gly His Arg Phe Tyr 
        515                 520                 525             

His Tyr Val Ala Gln Asn Ala Ser Ile Pro Val Ala Ser His Leu Ser 
    530                 535                 540                 

Asp Met Glu Val Gly Lys Lys Tyr Tyr Ser Ala Asp Gly Leu His Phe 
545                 550                 555                 560 

Asp Gly Phe Lys Leu Glu Asn Pro Phe Leu Phe Lys Asp Leu Thr Glu 
                565                 570                 575     

Ala Thr Asn Tyr Ser Ala Glu Glu Leu Asp Lys Val Phe Ser Leu Leu 
            580                 585                 590         

Asn Ile Asn Asn Ser Leu Leu Glu Asn Lys Gly Ala Thr Phe Lys Glu 
        595                 600                 605             

Ala Glu Glu His Tyr His Ile Asn Ala Leu Tyr Leu Leu Ala His Ser 
    610                 615                 620                 

Ala Leu Glu Ser Asn Trp Gly Arg Ser Lys Ile Ala Lys Asp Lys Asn 
625                 630                 635                 640 

Asn Phe Phe Gly Ile Thr Ala Tyr Asp Thr Thr Pro Tyr Leu Ser Ala 
                645                 650                 655     

Lys Thr Phe Asp Asp Val Asp Lys Gly Ile Leu Gly Ala Thr Lys Trp 
            660                 665                 670         

Ile Lys Glu Asn Tyr Ile Asp Arg Gly Arg Thr Phe Leu Gly Asn Lys 
        675                 680                 685             

Ala Ser Gly Met Asn Val Glu Tyr Ala Ser Asp Pro Tyr Trp Gly Glu 
    690                 695                 700                 

Lys Ile Ala Ser Val Met Met Lys Ile Asn Glu Lys Leu Gly Gly Lys 
705                 710                 715                 720 

Asp 
    

<210>   31
<211>   501
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr1431 as found in the R6 strain

<400>   31
Met Ser Val Thr Phe Phe Ile Gly Glu Glu Arg Leu Lys Ile Lys Ile 
1               5                   10                  15      

Gly Leu Ala Ser Ile Cys Leu Leu Gly Leu Ala Thr Ser His Val Ala 
            20                  25                  30          

Ala Asn Glu Thr Glu Val Ala Lys Thr Ser Gln Asp Thr Thr Thr Ala 
        35                  40                  45              

Ser Ser Ser Ser Glu Gln Asn Gln Ser Ser Asn Lys Thr Gln Thr Ser 
    50                  55                  60                  

Ala Glu Val Gln Thr Asn Ala Ala Ala Tyr Trp Asp Gly Asp Tyr Tyr 
65                  70                  75                  80  

Val Lys Asp Asp Gly Ser Lys Ala Gln Ser Glu Trp Ile Phe Asp Asn 
                85                  90                  95      

Tyr Tyr Lys Ala Trp Phe Tyr Ile Asn Ser Asp Gly Arg Tyr Ser Gln 
            100                 105                 110         

Asn Glu Trp His Gly Asn Tyr Tyr Leu Lys Ser Gly Gly Tyr Met Ala 
        115                 120                 125             

Gln Asn Glu Trp Ile Tyr Asp Ser Asn Tyr Lys Ser Trp Phe Tyr Leu 
    130                 135                 140                 

Lys Ser Asp Gly Ala Tyr Ala His Gln Glu Trp Gln Leu Ile Gly Asn 
145                 150                 155                 160 

Lys Trp Tyr Tyr Phe Lys Lys Trp Gly Tyr Met Ala Lys Ser Gln Trp 
                165                 170                 175     

Gln Gly Ser Tyr Phe Leu Asn Gly Gln Gly Ala Met Ile Gln Asn Glu 
            180                 185                 190         

Trp Leu Tyr Asp Pro Ala Tyr Ser Ala Tyr Phe Tyr Leu Lys Ser Asp 
        195                 200                 205             

Gly Thr Tyr Ala Asn Gln Glu Trp Gln Lys Val Gly Gly Lys Trp Tyr 
    210                 215                 220                 

Tyr Phe Lys Lys Trp Gly Tyr Met Ala Arg Asn Glu Trp Gln Gly Asn 
225                 230                 235                 240 

Tyr Tyr Leu Thr Gly Ser Gly Ala Met Ala Thr Asp Glu Val Ile Met 
                245                 250                 255     

Asp Gly Ala Arg Tyr Ile Phe Ala Ala Ser Gly Glu Leu Lys Glu Lys 
            260                 265                 270         

Lys Asp Leu Asn Val Gly Trp Val His Arg Asp Gly Lys Arg Tyr Phe 
        275                 280                 285             

Phe Asn Asn Arg Glu Glu Gln Val Gly Thr Glu His Ala Lys Lys Ile 
    290                 295                 300                 

Ile Asp Ile Ser Glu His Asn Gly Arg Ile Asn Asp Trp Lys Lys Val 
305                 310                 315                 320 

Ile Asp Glu Asn Lys Val Asp Gly Val Ile Val Arg Leu Gly Tyr Ser 
                325                 330                 335     

Gly Lys Glu Asp Lys Glu Leu Ala His Asn Ile Lys Glu Leu Asn Arg 
            340                 345                 350         

Leu Gly Ile Pro Tyr Gly Val Tyr Leu Tyr Thr Tyr Ala Glu Asn Glu 
        355                 360                 365             

Thr Asp Ala Glu Asn Asp Ala Lys Gln Thr Ile Glu Leu Ile Lys Lys 
    370                 375                 380                 

Tyr Asn Met Asn Leu Ser Tyr Pro Ile Tyr Tyr Asp Val Glu Asn Trp 
385                 390                 395                 400 

Glu Tyr Val Asn Lys Ser Lys Arg Ala Pro Ser Asp Thr Asp Thr Trp 
                405                 410                 415     

Val Lys Ile Ile Asn Lys Tyr Met Asp Thr Met Lys Gln Ala Gly Tyr 
            420                 425                 430         

Gln Asn Val Tyr Val Tyr Ser Tyr Arg Ser Leu Leu Gln Thr Arg Leu 
        435                 440                 445             

Lys His Pro Asp Ile Leu Lys His Val Asn Trp Val Ala Ala Tyr Thr 
    450                 455                 460                 

Asn Ala Leu Glu Trp Glu Asn Pro Tyr Tyr Ser Gly Glu Lys Gly Trp 
465                 470                 475                 480 

Gln Tyr Thr Ser Ser Glu Tyr Met Lys Gly Ile Gln Gly Arg Val Asp 
                485                 490                 495     

Val Ser Val Trp Tyr 
            500     

<210>   32
<211>   471
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr1739 as found in the R6 strain

<400>   32
Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      

Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          

Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              

Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  

Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  

Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      

Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         

Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             

Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 

Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 

Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     

Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         

Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             

Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 

Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 

Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     

Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         

Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             

Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 

Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 

Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     

Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         

Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             

Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asp Glu Leu Ser Tyr 
    370                 375                 380                 

Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 

Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     

Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         

Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             

Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 

Glu Asp Lys Val Glu Asn Asp 
465                 470     

<210>   33
<211>   392
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr2021 as found in the R6 strain

<400>   33
Met Lys Lys Lys Ile Leu Ala Ser Leu Leu Leu Ser Thr Val Met Val 
1               5                   10                  15      

Ser Gln Val Ala Val Leu Thr Thr Ala His Ala Glu Thr Thr Asp Asp 
            20                  25                  30          

Lys Ile Ala Ala Gln Asp Asn Lys Ile Ser Asn Leu Thr Ala Gln Gln 
        35                  40                  45              

Gln Glu Ala Gln Lys Gln Val Asp Gln Ile Gln Glu Gln Val Ser Ala 
    50                  55                  60                  

Ile Gln Ala Glu Gln Ser Asn Leu Gln Ala Glu Asn Asp Arg Leu Gln 
65                  70                  75                  80  

Ala Glu Ser Lys Lys Leu Glu Gly Glu Ile Thr Glu Leu Ser Lys Asn 
                85                  90                  95      

Ile Val Ser Arg Asn Gln Ser Leu Glu Lys Gln Ala Arg Ser Ala Gln 
            100                 105                 110         

Thr Asn Gly Ala Val Thr Ser Tyr Ile Asn Thr Ile Val Asn Ser Lys 
        115                 120                 125             

Ser Ile Thr Glu Ala Ile Ser Arg Val Ala Ala Met Ser Glu Ile Val 
    130                 135                 140                 

Ser Ala Asn Asn Lys Met Leu Glu Gln Gln Lys Ala Asp Lys Lys Ala 
145                 150                 155                 160 

Ile Ser Glu Lys Gln Val Ala Asn Asn Asp Ala Ile Asn Thr Val Ile 
                165                 170                 175     

Ala Asn Gln Gln Lys Leu Ala Asp Asp Ala Gln Ala Leu Thr Thr Lys 
            180                 185                 190         

Gln Ala Glu Leu Lys Ala Ala Glu Leu Ser Leu Ala Ala Glu Lys Ala 
        195                 200                 205             

Thr Ala Glu Gly Glu Lys Ala Ser Leu Leu Glu Gln Lys Ala Ala Ala 
    210                 215                 220                 

Glu Ala Glu Ala Arg Ala Ala Ala Val Ala Glu Ala Ala Tyr Lys Glu 
225                 230                 235                 240 

Lys Arg Ala Ser Gln Gln Gln Ser Val Leu Ala Ser Ala Asn Thr Asn 
                245                 250                 255     

Leu Thr Ala Gln Val Gln Ala Val Ser Glu Ser Ala Ala Ala Pro Val 
            260                 265                 270         

Arg Ala Lys Val Arg Pro Thr Tyr Ser Thr Asn Ala Ser Ser Tyr Pro 
        275                 280                 285             

Ile Gly Glu Cys Thr Trp Gly Val Lys Thr Leu Ala Pro Trp Ala Gly 
    290                 295                 300                 

Asp Tyr Trp Gly Asn Gly Ala Gln Trp Ala Thr Ser Ala Ala Ala Ala 
305                 310                 315                 320 

Gly Phe Arg Thr Gly Ser Thr Pro Gln Val Gly Ala Ile Ala Cys Trp 
                325                 330                 335     

Asn Asp Gly Gly Tyr Gly His Val Ala Val Val Thr Ala Val Glu Ser 
            340                 345                 350         

Thr Thr Arg Ile Gln Val Ser Glu Ser Asn Tyr Ala Gly Asn Arg Thr 
        355                 360                 365             

Ile Gly Asn His Arg Gly Trp Phe Asn Pro Thr Thr Thr Ser Glu Gly 
    370                 375                 380                 

Phe Val Thr Tyr Ile Tyr Ala Asp 
385                 390         

<210>   34
<211>   167
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr0096 as found in the R6 strain

<400>   34
Met Lys Ser Ile Thr Lys Lys Ile Lys Ala Thr Leu Ala Gly Val Ala 
1               5                   10                  15      

Ala Leu Phe Ala Val Phe Ala Pro Ser Phe Val Ser Ala Gln Glu Ser 
            20                  25                  30          

Ser Thr Tyr Thr Val Lys Glu Gly Asp Thr Leu Ser Glu Ile Ala Glu 
        35                  40                  45              

Thr His Asn Thr Thr Val Glu Lys Leu Ala Glu Asn Asn His Ile Asp 
    50                  55                  60                  

Asn Ile His Leu Ile Tyr Val Asp Gln Glu Leu Val Ile Asp Gly Pro 
65                  70                  75                  80  

Val Ala Pro Val Ala Thr Pro Ala Pro Ala Thr Tyr Ala Ala Pro Ala 
                85                  90                  95      

Ala Gln Asp Glu Thr Val Ser Ala Pro Val Ala Glu Thr Pro Val Val 
            100                 105                 110         

Ser Glu Thr Val Val Ser Thr Val Ser Gly Ser Glu Ala Glu Ala Lys 
        115                 120                 125             

Glu Trp Ile Ala Gln Lys Glu Ser Gly Gly Ser Tyr Thr Ala Thr Asn 
    130                 135                 140                 

Gly Arg Tyr Ile Gly Arg Tyr Gly Ser Trp Thr Ala Ala Lys Asn Phe 
145                 150                 155                 160 

Trp Leu Asn Asn Gly Trp Tyr 
                165         

<210>   35
<211>   380
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr1875 as found in the R6 strain

<400>   35
Met Lys Lys Arg Met Leu Leu Ala Ser Thr Val Ala Leu Ser Phe Ala 
1               5                   10                  15      

Pro Val Leu Ala Thr Gln Ala Glu Glu Val Leu Trp Thr Ala Arg Ser 
            20                  25                  30          

Val Glu Gln Ile Gln Asn Asp Leu Thr Lys Thr Asp Asn Lys Thr Ser 
        35                  40                  45              

Tyr Thr Val Gln Tyr Gly Asp Thr Leu Ser Thr Ile Ala Glu Ala Leu 
    50                  55                  60                  

Gly Val Asp Val Thr Val Leu Ala Asn Leu Asn Lys Ile Thr Asn Met 
65                  70                  75                  80  

Asp Leu Ile Phe Pro Glu Thr Val Leu Thr Thr Thr Val Asn Glu Ala 
                85                  90                  95      

Glu Glu Val Thr Glu Val Glu Ile Gln Thr Pro Gln Ala Asp Ser Ser 
            100                 105                 110         

Glu Glu Val Thr Thr Ala Thr Ala Asp Leu Thr Thr Asn Gln Val Thr 
        115                 120                 125             

Val Asp Asp Gln Thr Val Gln Val Ala Asp Leu Ser Gln Pro Ile Ala 
    130                 135                 140                 

Glu Ala Pro Lys Glu Val Ala Ser Ser Ser Glu Val Thr Lys Thr Val 
145                 150                 155                 160 

Ile Ala Ser Glu Glu Val Ala Pro Ser Thr Gly Thr Ser Val Pro Glu 
                165                 170                 175     

Glu Gln Thr Ala Glu Thr Ser Ser Ala Val Ala Glu Glu Ala Pro Gln 
            180                 185                 190         

Glu Thr Thr Pro Ala Glu Lys Gln Glu Thr Gln Thr Ser Pro Gln Ala 
        195                 200                 205             

Ala Ser Ala Val Glu Ala Thr Thr Thr Ser Ser Glu Ala Lys Glu Val 
    210                 215                 220                 

Ala Ser Ser Asn Gly Ala Thr Ala Ala Val Ser Thr Tyr Gln Pro Glu 
225                 230                 235                 240 

Glu Thr Lys Ile Ile Ser Thr Thr Tyr Glu Ala Pro Ala Ala Pro Asp 
                245                 250                 255     

Tyr Ala Gly Leu Ala Val Ala Lys Ser Glu Asn Ala Gly Leu Gln Pro 
            260                 265                 270         

Gln Thr Ala Ala Phe Lys Glu Glu Ile Ala Asn Leu Phe Gly Ile Thr 
        275                 280                 285             

Ser Phe Ser Gly Tyr Arg Pro Gly Asp Ser Gly Asp His Gly Lys Gly 
    290                 295                 300                 

Leu Ala Ile Asp Phe Met Val Pro Glu Arg Ser Glu Leu Gly Asp Lys 
305                 310                 315                 320 

Ile Ala Glu Tyr Ala Ile Gln Asn Met Ala Ser Arg Gly Ile Ser Tyr 
                325                 330                 335     

Ile Ile Trp Lys Gln Arg Phe Tyr Ala Pro Phe Asp Ser Lys Tyr Gly 
            340                 345                 350         

Pro Ala Asn Thr Trp Asn Pro Met Pro Asp Arg Gly Ser Val Thr Glu 
        355                 360                 365             

Asn His Tyr Asp His Val His Val Ser Met Asn Gly 
    370                 375                 380 

<210>   36
<211>   659
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr1707 as found in the R6 strain

<400>   36
Met Lys Lys Asn Arg Val Phe Ala Thr Ala Gly Leu Val Leu Leu Ala 
1               5                   10                  15      

Ala Gly Val Leu Ala Ala Cys Ser Ser Ser Lys Ser Ser Asp Ser Ser 
            20                  25                  30          

Ala Pro Lys Ala Tyr Gly Tyr Val Tyr Thr Ala Asp Pro Glu Thr Leu 
        35                  40                  45              

Asp Tyr Leu Ile Ser Arg Lys Asn Ser Thr Thr Val Val Thr Ser Asn 
    50                  55                  60                  

Gly Ile Asp Gly Leu Phe Thr Asn Asp Asn Tyr Gly Asn Leu Ala Pro 
65                  70                  75                  80  

Ala Val Ala Glu Asp Trp Glu Val Ser Lys Asp Gly Leu Thr Tyr Thr 
                85                  90                  95      

Tyr Lys Ile Arg Lys Gly Val Lys Trp Phe Thr Ser Asp Gly Glu Glu 
            100                 105                 110         

Tyr Ala Glu Val Thr Ala Lys Asp Phe Val Asn Gly Leu Lys His Ala 
        115                 120                 125             

Ala Asp Lys Lys Ser Glu Ala Met Tyr Leu Ala Glu Asn Ser Val Lys 
    130                 135                 140                 

Gly Leu Ala Asp Tyr Leu Ser Gly Thr Ser Thr Asp Phe Ser Thr Val 
145                 150                 155                 160 

Gly Val Lys Ala Val Asp Asp Tyr Thr Leu Gln Tyr Thr Leu Asn Gln 
                165                 170                 175     

Pro Glu Pro Phe Trp Asn Ser Lys Leu Thr Tyr Ser Ile Phe Trp Pro 
            180                 185                 190         

Leu Asn Glu Glu Phe Glu Thr Ser Lys Gly Ser Asp Phe Ala Lys Pro 
        195                 200                 205             

Thr Asp Pro Thr Ser Leu Leu Tyr Asn Gly Pro Phe Leu Leu Lys Gly 
    210                 215                 220                 

Leu Thr Ala Lys Ser Ser Val Glu Phe Val Lys Asn Glu Gln Tyr Trp 
225                 230                 235                 240 

Asp Lys Glu Asn Val His Leu Asp Thr Ile Asn Leu Ala Tyr Tyr Asp 
                245                 250                 255     

Gly Ser Asp Gln Glu Ser Leu Glu Arg Asn Phe Thr Ser Gly Ala Tyr 
            260                 265                 270         

Ser Tyr Ala Arg Leu Tyr Pro Thr Ser Ser Asn Tyr Ser Lys Val Ala 
        275                 280                 285             

Glu Glu Tyr Lys Asp Asn Ile Tyr Tyr Thr Gln Ser Gly Ser Gly Ile 
    290                 295                 300                 

Ala Gly Leu Gly Val Asn Ile Asp Arg Gln Ser Tyr Asn Tyr Thr Ser 
305                 310                 315                 320 

Lys Thr Thr Asp Ser Glu Lys Val Ala Thr Lys Lys Ala Leu Leu Asn 
                325                 330                 335     

Lys Asp Phe Arg Gln Ala Leu Asn Phe Ala Leu Asp Arg Ser Ala Tyr 
            340                 345                 350         

Ser Ala Gln Ile Asn Gly Lys Asp Gly Ala Ala Leu Ala Val Arg Asn 
        355                 360                 365             

Leu Phe Val Lys Pro Asp Phe Val Ser Ala Gly Glu Lys Thr Phe Gly 
    370                 375                 380                 

Asp Leu Val Ala Ala Gln Leu Pro Ala Tyr Gly Asp Glu Trp Lys Gly 
385                 390                 395                 400 

Val Asn Leu Ala Asp Gly Gln Asp Gly Leu Phe Asn Ala Asp Lys Ala 
                405                 410                 415     

Lys Ala Glu Phe Ala Lys Ala Lys Lys Ala Leu Glu Ala Asp Gly Val 
            420                 425                 430         

Gln Phe Pro Ile His Leu Asp Val Pro Val Asp Gln Ala Ser Lys Asn 
        435                 440                 445             

Tyr Ile Ser Arg Ile Gln Ser Phe Lys Gln Ser Val Glu Thr Val Leu 
    450                 455                 460                 

Gly Val Glu Asn Val Val Val Asp Ile Gln Gln Met Thr Ser Asp Glu 
465                 470                 475                 480 

Phe Leu Asn Ile Thr Tyr Tyr Ala Ala Asn Ala Ser Ser Glu Asp Trp 
                485                 490                 495     

Asp Val Ser Gly Gly Val Ser Trp Gly Pro Asp Tyr Gln Asp Pro Ser 
            500                 505                 510         

Thr Tyr Leu Asp Ile Leu Lys Thr Thr Ser Ser Glu Thr Thr Lys Thr 
        515                 520                 525             

Tyr Leu Gly Phe Asp Asn Pro Asn Ser Pro Ser Val Val Gln Val Gly 
    530                 535                 540                 

Leu Lys Glu Tyr Asp Lys Leu Val Asp Glu Ala Ala Lys Glu Thr Ser 
545                 550                 555                 560 

Asp Leu Asn Val Arg Tyr Glu Lys Tyr Ala Ala Ala Gln Ala Trp Leu 
                565                 570                 575     

Thr Asp Ser Ser Leu Phe Ile Pro Ala Met Ala Ser Ser Gly Ala Ala 
            580                 585                 590         

Pro Val Leu Ser Arg Ile Val Pro Phe Thr Gly Ala Ser Ala Gln Thr 
        595                 600                 605             

Gly Ser Lys Gly Ser Asp Val Tyr Phe Lys Tyr Leu Lys Leu Gln Asp 
    610                 615                 620                 

Lys Ala Val Thr Lys Glu Glu Tyr Glu Lys Ala Arg Glu Lys Trp Leu 
625                 630                 635                 640 

Lys Glu Lys Ala Glu Ser Asn Glu Lys Ala Gln Lys Glu Leu Ala Ser 
                645                 650                 655     

His Val Lys 
            

<210>   37
<211>   313
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid sequence of full length spr0884

<400>   37
Met Lys Lys Lys Leu Leu Ala Gly Ala Ile Thr Leu Leu Ser Val Ala 
1               5                   10                  15      

Thr Leu Ala Ala Cys Ser Lys Gly Ser Glu Gly Ala Asp Leu Ile Ser 
            20                  25                  30          

Met Lys Gly Asp Val Ile Thr Glu His Gln Phe Tyr Glu Gln Val Lys 
        35                  40                  45              

Asn Asn Pro Ser Ala Gln Gln Val Leu Leu Asn Met Thr Ile Gln Lys 
    50                  55                  60                  

Val Phe Glu Lys Gln Tyr Gly Ser Glu Leu Asp Asp Lys Glu Val Asp 
65                  70                  75                  80  

Asp Thr Ile Ala Glu Glu Lys Lys Gln Tyr Gly Glu Asn Tyr Gln Arg 
                85                  90                  95      

Val Leu Ser Gln Ala Gly Met Thr Leu Glu Thr Arg Lys Ala Gln Ile 
            100                 105                 110         

Arg Thr Ser Lys Leu Val Glu Leu Ala Val Lys Lys Val Ala Glu Ala 
        115                 120                 125             

Glu Leu Thr Asp Glu Ala Tyr Lys Lys Ala Phe Asp Glu Tyr Thr Pro 
    130                 135                 140                 

Asp Val Thr Ala Gln Ile Ile Arg Leu Asn Asn Glu Asp Lys Ala Lys 
145                 150                 155                 160 

Glu Val Leu Glu Lys Ala Lys Ala Glu Gly Ala Asp Phe Ala Gln Leu 
                165                 170                 175     

Ala Lys Asp Asn Ser Thr Asp Glu Lys Thr Lys Glu Asn Gly Gly Glu 
            180                 185                 190         

Ile Thr Phe Asp Ser Ala Ser Thr Glu Val Pro Glu Gln Val Lys Lys 
        195                 200                 205             

Ala Ala Phe Ala Leu Asp Val Asp Gly Val Ser Asp Val Ile Thr Ala 
    210                 215                 220                 

Thr Gly Thr Gln Ala Tyr Ser Ser Gln Tyr Tyr Ile Val Lys Leu Thr 
225                 230                 235                 240 

Lys Lys Thr Glu Lys Ser Ser Asn Ile Asp Asp Tyr Lys Glu Lys Leu 
                245                 250                 255     

Lys Thr Val Ile Leu Thr Gln Lys Gln Asn Asp Ser Thr Phe Val Gln 
            260                 265                 270         

Ser Ile Ile Gly Lys Glu Leu Gln Ala Ala Asn Ile Lys Val Lys Asp 
        275                 280                 285             

Gln Ala Phe Gln Asn Ile Phe Thr Gln Tyr Ile Gly Gly Gly Asp Ser 
    290                 295                 300                 

Ser Ser Ser Ser Ser Thr Ser Asn Glu 
305                 310             

<210>   38
<211>   1247
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr0057 protein which omits the natural leader peptide and sortase recognition sequences

<400>   38
Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr Ile His 
1               5                   10                  15      

Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu Glu Thr 
            20                  25                  30          

Pro Lys Ala Glu Leu Gln Pro Glu Ala Pro Lys Thr Val Glu Thr Glu 
        35                  40                  45              

Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu Glu Lys 
    50                  55                  60                  

Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu Val Val 
65                  70                  75                  80  

Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Glu Glu Glu 
                85                  90                  95      

Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys Glu Ser 
            100                 105                 110         

Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp Glu Ala 
        115                 120                 125             

Lys Ala Glu Ala Asp Lys Pro Glu Thr Glu Thr Gly Lys Glu Arg Ala 
    130                 135                 140                 

Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser Ile Asp 
145                 150                 155                 160 

Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile Ile Asp 
                165                 170                 175     

Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val Gly Asn 
            180                 185                 190         

Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala Asn Gly 
        195                 200                 205             

Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys Gly Thr 
    210                 215                 220                 

Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu Ser Gln 
225                 230                 235                 240 

Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly Leu Ile 
                245                 250                 255     

Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn Ala Met 
            260                 265                 270         

Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly Lys Lys 
        275                 280                 285             

Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala Phe Thr 
    290                 295                 300                 

Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys Thr Glu 
305                 310                 315                 320 

Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr Asp Ala 
                325                 330                 335     

Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn Glu Gly 
            340                 345                 350         

Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn Asp Leu 
        355                 360                 365             

Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe Asn Asp 
    370                 375                 380                 

Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp Lys Asp 
385                 390                 395                 400 

Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp Val Ala 
                405                 410                 415     

Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn Thr Asn 
            420                 425                 430         

Asp Ala Trp Cys Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln Gly Trp 
        435                 440                 445             

Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro Ile Thr 
    450                 455                 460                 

Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly Gly Met 
465                 470                 475                 480 

Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro Ser His 
                485                 490                 495     

Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu Tyr Phe 
            500                 505                 510         

Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val Pro Lys 
        515                 520                 525             

Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Ala Ala Val Lys Glu Ala 
    530                 535                 540                 

Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala Gln Gln 
545                 550                 555                 560 

Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val Asn Asn 
                565                 570                 575     

Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys Arg Glu 
            580                 585                 590         

Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala Gly Arg 
        595                 600                 605             

Lys Tyr Phe Thr Leu Asp Gln Leu Lys Arg Ile Val Asp Lys Ala Ser 
    610                 615                 620                 

Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp Gly Leu 
625                 630                 635                 640 

Arg Phe Leu Leu Asn Asp Met Thr Ile Thr Ala Asn Gly Lys Thr Tyr 
                645                 650                 655     

Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys Ala Tyr 
            660                 665                 670         

Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val Thr Glu 
        675                 680                 685             

Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro Ala Ile 
    690                 695                 700                 

Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu Lys Leu 
705                 710                 715                 720 

Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys Thr Thr 
                725                 730                 735     

Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala Leu Ile 
            740                 745                 750         

Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe Asn Phe 
        755                 760                 765             

Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly Trp Tyr 
    770                 775                 780                 

Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr Ala Asn 
785                 790                 795                 800 

Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met Ala Phe 
                805                 810                 815     

Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe Asp Lys 
            820                 825                 830         

Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr Asn Leu 
        835                 840                 845             

Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu Asn Thr 
    850                 855                 860                 

Asn Gly Asp Trp Tyr Tyr Val Ile Gly Asn His Lys Gln Asp Glu Ala 
865                 870                 875                 880 

Tyr Pro Leu Ser Lys Ala Val Glu Asn Ser Gly Lys Val Pro Phe Asn 
                885                 890                 895     

Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr Val Gly 
            900                 905                 910         

Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr Lys Glu 
        915                 920                 925             

Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn Lys Asp 
    930                 935                 940                 

Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala Lys Ile 
945                 950                 955                 960 

Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala Leu Asp 
                965                 970                 975     

Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys Gln Ala 
            980                 985                 990         

Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln Gly Leu 
        995                 1000                1005            

Lys Pro Ala Ala Thr His Ser Gly Ser Leu Asp Glu Asn Glu Val Ala 
    1010                1015                1020                

Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu Glu Ile 
1025                1030                1035                1040

Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala Gly Gln 
                1045                1050                1055    

Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His Tyr Ile 
            1060                1065                1070        

Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu Asp Ser 
        1075                1080                1085            

Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly Ser Pro 
    1090                1095                1100                

Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr Glu Val 
1105                1110                1115                1120

Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr Thr Val 
                1125                1130                1135    

Thr Arg Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val Ile Thr 
            1140                1145                1150        

Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser Thr Ser 
        1155                1160                1165            

Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val Ala Gln 
    1170                1175                1180                

Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr His Val 
1185                1190                1195                1200

Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro Lys Leu 
                1205                1210                1215    

Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu Glu Ser 
            1220                1225                1230        

Lys Ala Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys Lys 
        1235                1240                1245        

<210>   39
<211>   1008
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr0286

<400>   39
Gly Ala Glu Glu Thr Thr Thr Asn Thr Ile Gln Gln Ser Gln Lys Glu 
1               5                   10                  15      

Val Gln Tyr Gln Gln Arg Asp Thr Lys Asn Leu Val Glu Asn Gly Asp 
            20                  25                  30          

Phe Gly Gln Thr Glu Asp Gly Ser Ser Pro Trp Thr Gly Ser Lys Ala 
        35                  40                  45              

Gln Gly Trp Ser Ala Trp Val Asp Gln Lys Asn Ser Ser Ala Asp Ala 
    50                  55                  60                  

Ser Thr Arg Val Ile Glu Ala Lys Asp Gly Ala Ile Thr Ile Ser Ser 
65                  70                  75                  80  

Pro Glu Lys Leu Arg Ala Ala Val His Arg Met Val Pro Ile Glu Ala 
                85                  90                  95      

Lys Lys Lys Tyr Lys Leu Arg Phe Lys Ile Lys Thr Asp Asn Lys Val 
            100                 105                 110         

Gly Ile Ala Lys Val Arg Ile Ile Glu Glu Ser Gly Lys Asp Lys Arg 
        115                 120                 125             

Leu Trp Asn Ser Ala Thr Thr Ser Gly Thr Lys Asp Trp Gln Thr Ile 
    130                 135                 140                 

Glu Ala Asp Tyr Ser Pro Thr Leu Asp Val Asp Lys Ile Lys Leu Glu 
145                 150                 155                 160 

Leu Phe Tyr Glu Thr Gly Thr Gly Thr Val Ser Phe Lys Asp Ile Glu 
                165                 170                 175     

Leu Val Glu Val Ala Asp Gln Pro Ser Glu Asp Ser Gln Thr Asp Lys 
            180                 185                 190         

Gln Leu Glu Glu Lys Ile Asp Leu Pro Ile Gly Lys Lys His Val Phe 
        195                 200                 205             

Ser Leu Ala Asp Tyr Thr Tyr Lys Val Glu Asn Pro Asp Val Ala Ser 
    210                 215                 220                 

Val Lys Asn Gly Ile Leu Glu Pro Leu Lys Glu Gly Thr Thr Asn Val 
225                 230                 235                 240 

Ile Val Ser Lys Asp Gly Lys Glu Val Lys Lys Ile Pro Leu Lys Ile 
                245                 250                 255     

Leu Ala Ser Val Lys Asp Thr Tyr Thr Asp Arg Leu Asp Asp Trp Asn 
            260                 265                 270         

Gly Ile Ile Ala Gly Asn Gln Tyr Tyr Asp Ser Lys Asn Glu Gln Met 
        275                 280                 285             

Ala Lys Leu Asn Gln Glu Leu Glu Gly Lys Val Ala Asp Ser Leu Ser 
    290                 295                 300                 

Ser Ile Ser Ser Gln Ala Asp Arg Ile Tyr Leu Trp Glu Lys Phe Ser 
305                 310                 315                 320 

Asn Tyr Lys Thr Ser Ala Asn Leu Thr Ala Thr Tyr Arg Lys Leu Glu 
                325                 330                 335     

Glu Met Ala Lys Gln Val Thr Asn Pro Ser Ser Arg Tyr Tyr Gln Asp 
            340                 345                 350         

Glu Thr Val Val Arg Thr Val Arg Asp Ser Met Glu Trp Met His Lys 
        355                 360                 365             

His Val Tyr Asn Ser Glu Lys Ser Ile Val Gly Asn Trp Trp Asp Tyr 
    370                 375                 380                 

Glu Ile Gly Thr Pro Arg Ala Ile Asn Asn Thr Leu Ser Leu Met Lys 
385                 390                 395                 400 

Glu Tyr Phe Ser Asp Glu Glu Ile Lys Lys Tyr Thr Asp Val Ile Glu 
                405                 410                 415     

Lys Phe Val Pro Asp Pro Glu His Phe Arg Lys Thr Thr Asp Asn Pro 
            420                 425                 430         

Phe Lys Ala Leu Gly Gly Asn Leu Val Asp Met Gly Arg Val Lys Val 
        435                 440                 445             

Ile Ala Gly Leu Leu Arg Lys Asp Asp Gln Glu Ile Ser Ser Thr Ile 
    450                 455                 460                 

Arg Ser Ile Glu Gln Val Phe Lys Leu Val Asp Gln Gly Glu Gly Phe 
465                 470                 475                 480 

Tyr Gln Asp Gly Ser Tyr Ile Asp His Thr Asn Val Ala Tyr Thr Gly 
                485                 490                 495     

Ala Tyr Gly Asn Val Leu Ile Asp Gly Leu Ser Gln Leu Leu Pro Val 
            500                 505                 510         

Ile Gln Lys Thr Lys Asn Pro Ile Asp Lys Asp Lys Met Gln Thr Met 
        515                 520                 525             

Tyr His Trp Ile Asp Lys Ser Phe Ala Pro Leu Leu Val Asn Gly Glu 
    530                 535                 540                 

Leu Met Asp Met Ser Arg Gly Arg Ser Ile Ser Arg Ala Asn Ser Glu 
545                 550                 555                 560 

Gly His Val Ala Ala Val Glu Val Leu Arg Gly Ile His Arg Ile Ala 
                565                 570                 575     

Asp Met Ser Glu Gly Glu Thr Lys Gln Arg Leu Gln Ser Leu Val Lys 
            580                 585                 590         

Thr Ile Val Gln Ser Asp Ser Tyr Tyr Asp Val Phe Lys Asn Leu Lys 
        595                 600                 605             

Thr Tyr Lys Asp Ile Ser Leu Met Gln Ser Leu Leu Ser Asp Ala Gly 
    610                 615                 620                 

Val Ala Ser Val Pro Arg Thr Ser Tyr Leu Ser Ala Phe Asn Lys Met 
625                 630                 635                 640 

Asp Lys Thr Ala Met Tyr Asn Ala Glu Lys Gly Phe Gly Phe Gly Leu 
                645                 650                 655     

Ser Leu Phe Ser Ser Arg Thr Leu Asn Tyr Glu His Met Asn Lys Glu 
            660                 665                 670         

Asn Lys Arg Gly Trp Tyr Thr Ser Asp Gly Met Phe Tyr Leu Tyr Asn 
        675                 680                 685             

Gly Asp Leu Ser His Tyr Ser Asp Gly Tyr Trp Pro Thr Val Asn Pro 
    690                 695                 700                 

Tyr Lys Met Pro Gly Thr Thr Glu Thr Asp Ala Lys Arg Ala Asp Ser 
705                 710                 715                 720 

Asp Thr Gly Lys Val Leu Pro Ser Ala Phe Val Gly Thr Ser Lys Leu 
                725                 730                 735     

Asp Asp Ala Asn Ala Thr Ala Thr Met Asp Phe Thr Asn Trp Asn Gln 
            740                 745                 750         

Thr Leu Thr Ala His Lys Ser Trp Phe Met Leu Lys Asp Lys Ile Ala 
        755                 760                 765             

Phe Leu Gly Ser Asn Ile Gln Asn Thr Ser Thr Asp Thr Ala Ala Thr 
    770                 775                 780                 

Thr Ile Asp Gln Arg Lys Leu Glu Ser Ser Asn Pro Tyr Lys Val Tyr 
785                 790                 795                 800 

Val Asn Asp Lys Glu Ala Ser Leu Thr Glu Gln Glu Lys Asp Tyr Pro 
                805                 810                 815     

Glu Thr Gln Ser Val Phe Leu Glu Ser Ser Asp Ser Lys Lys Asn Ile 
            820                 825                 830         

Gly Tyr Phe Phe Phe Lys Lys Ser Ser Ile Ser Met Ser Lys Ala Leu 
        835                 840                 845             

Gln Lys Gly Ala Trp Lys Asp Ile Asn Glu Gly Gln Ser Asp Lys Glu 
    850                 855                 860                 

Val Glu Asn Glu Phe Leu Thr Ile Ser Gln Ala His Lys Gln Asn Gly 
865                 870                 875                 880 

Asp Ser Tyr Gly Tyr Met Leu Ile Pro Asn Val Asp Arg Ala Thr Phe 
                885                 890                 895     

Asn Gln Met Ile Lys Glu Leu Glu Ser Ser Leu Ile Glu Asn Asn Glu 
            900                 905                 910         

Thr Leu Gln Ser Val Tyr Asp Ala Lys Gln Gly Val Trp Gly Ile Val 
        915                 920                 925             

Lys Tyr Asp Asp Ser Val Ser Thr Ile Ser Asn Gln Phe Gln Val Leu 
    930                 935                 940                 

Lys Arg Gly Val Tyr Thr Ile Arg Lys Glu Gly Asp Glu Tyr Lys Ile 
945                 950                 955                 960 

Ala Tyr Tyr Asn Pro Glu Thr Gln Glu Ser Ala Pro Asp Gln Glu Val 
                965                 970                 975     

Phe Lys Lys Leu Glu Gln Ala Ala Gln Pro Gln Val Gln Asn Ser Lys 
            980                 985                 990         

Glu Lys Glu Lys Ser Glu Glu Glu Lys Asn His Ser Asp Gln Lys Asn 
        995                 1000                1005            


<210>   40
<211>   628
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr0286 fragment

<400>   40
Gly Ala Glu Glu Thr Thr Thr Asn Thr Ile Gln Gln Ser Gln Lys Glu 
1               5                   10                  15      

Val Gln Tyr Gln Gln Arg Asp Thr Lys Asn Leu Val Glu Asn Gly Asp 
            20                  25                  30          

Phe Gly Gln Thr Glu Asp Gly Ser Ser Pro Trp Thr Gly Ser Lys Ala 
        35                  40                  45              

Gln Gly Trp Ser Ala Trp Val Asp Gln Lys Asn Ser Ser Ala Asp Ala 
    50                  55                  60                  

Ser Thr Arg Val Ile Glu Ala Lys Asp Gly Ala Ile Thr Ile Ser Ser 
65                  70                  75                  80  

Pro Glu Lys Leu Arg Ala Ala Val His Arg Met Val Pro Ile Glu Ala 
                85                  90                  95      

Lys Lys Lys Tyr Lys Leu Arg Phe Lys Ile Lys Thr Asp Asn Lys Val 
            100                 105                 110         

Gly Ile Ala Lys Val Arg Ile Ile Glu Glu Ser Gly Lys Asp Lys Arg 
        115                 120                 125             

Leu Trp Asn Ser Ala Thr Thr Ser Gly Thr Lys Asp Trp Gln Thr Ile 
    130                 135                 140                 

Glu Ala Asp Tyr Ser Pro Thr Leu Asp Val Asp Lys Ile Lys Leu Glu 
145                 150                 155                 160 

Leu Phe Tyr Glu Thr Gly Thr Gly Thr Val Ser Phe Lys Asp Ile Glu 
                165                 170                 175     

Leu Val Glu Val Ala Asp Gln Pro Ser Glu Asp Ser Gln Thr Asp Lys 
            180                 185                 190         

Gln Leu Glu Glu Lys Ile Asp Leu Pro Ile Gly Lys Lys His Val Phe 
        195                 200                 205             

Ser Leu Ala Asp Tyr Thr Tyr Lys Val Glu Asn Pro Asp Val Ala Ser 
    210                 215                 220                 

Val Lys Asn Gly Ile Leu Glu Pro Leu Lys Glu Gly Thr Thr Asn Val 
225                 230                 235                 240 

Ile Val Ser Lys Asp Gly Lys Glu Val Lys Lys Ile Pro Leu Lys Ile 
                245                 250                 255     

Leu Ala Ser Val Lys Asp Thr Tyr Thr Asp Arg Leu Asp Asp Trp Asn 
            260                 265                 270         

Gly Ile Ile Ala Gly Asn Gln Tyr Tyr Asp Ser Lys Asn Glu Gln Met 
        275                 280                 285             

Ala Lys Leu Asn Gln Glu Leu Glu Gly Lys Val Ala Asp Ser Leu Ser 
    290                 295                 300                 

Ser Ile Ser Ser Gln Ala Asp Arg Ile Tyr Leu Trp Glu Lys Phe Ser 
305                 310                 315                 320 

Asn Tyr Lys Thr Ser Ala Asn Leu Thr Ala Thr Tyr Arg Lys Leu Glu 
                325                 330                 335     

Glu Met Ala Lys Gln Val Thr Asn Pro Ser Ser Arg Tyr Tyr Gln Asp 
            340                 345                 350         

Glu Thr Val Val Arg Thr Val Arg Asp Ser Met Glu Trp Met His Lys 
        355                 360                 365             

His Val Tyr Asn Ser Glu Lys Ser Ile Val Gly Asn Trp Trp Asp Tyr 
    370                 375                 380                 

Glu Ile Gly Thr Pro Arg Ala Ile Asn Asn Thr Leu Ser Leu Met Lys 
385                 390                 395                 400 

Glu Tyr Phe Ser Asp Glu Glu Ile Lys Lys Tyr Thr Asp Val Ile Glu 
                405                 410                 415     

Lys Phe Val Pro Asp Pro Glu His Phe Arg Lys Thr Thr Asp Asn Pro 
            420                 425                 430         

Phe Lys Ala Leu Gly Gly Asn Leu Val Asp Met Gly Arg Val Lys Val 
        435                 440                 445             

Ile Ala Gly Leu Leu Arg Lys Asp Asp Gln Glu Ile Ser Ser Thr Ile 
    450                 455                 460                 

Arg Ser Ile Glu Gln Val Phe Lys Leu Val Asp Gln Gly Glu Gly Phe 
465                 470                 475                 480 

Tyr Gln Asp Gly Ser Tyr Ile Asp His Thr Asn Val Ala Tyr Thr Gly 
                485                 490                 495     

Ala Tyr Gly Asn Val Leu Ile Asp Gly Leu Ser Gln Leu Leu Pro Val 
            500                 505                 510         

Ile Gln Lys Thr Lys Asn Pro Ile Asp Lys Asp Lys Met Gln Thr Met 
        515                 520                 525             

Tyr His Trp Ile Asp Lys Ser Phe Ala Pro Leu Leu Val Asn Gly Glu 
    530                 535                 540                 

Leu Met Asp Met Ser Arg Gly Arg Ser Ile Ser Arg Ala Asn Ser Glu 
545                 550                 555                 560 

Gly His Val Ala Ala Val Glu Val Leu Arg Gly Ile His Arg Ile Ala 
                565                 570                 575     

Asp Met Ser Glu Gly Glu Thr Lys Gln Arg Leu Gln Ser Leu Val Lys 
            580                 585                 590         

Thr Ile Val Gln Ser Asp Ser Tyr Tyr Asp Val Phe Lys Asn Leu Lys 
        595                 600                 605             

Thr Tyr Lys Asp Ile Ser Leu Met Gln Ser Leu Leu Ser Asp Ala Gly 
    610                 615                 620                 

Val Ala Ser Val 
625             

<210>   41
<211>   452
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr0286 fragment

<400>   41
Ala Asn Ser Glu Gly His Val Ala Ala Val Glu Val Leu Arg Gly Ile 
1               5                   10                  15      

His Arg Ile Ala Asp Met Ser Glu Gly Glu Thr Lys Gln Arg Leu Gln 
            20                  25                  30          

Ser Leu Val Lys Thr Ile Val Gln Ser Asp Ser Tyr Tyr Asp Val Phe 
        35                  40                  45              

Lys Asn Leu Lys Thr Tyr Lys Asp Ile Ser Leu Met Gln Ser Leu Leu 
    50                  55                  60                  

Ser Asp Ala Gly Val Ala Ser Val Pro Arg Thr Ser Tyr Leu Ser Ala 
65                  70                  75                  80  

Phe Asn Lys Met Asp Lys Thr Ala Met Tyr Asn Ala Glu Lys Gly Phe 
                85                  90                  95      

Gly Phe Gly Leu Ser Leu Phe Ser Ser Arg Thr Leu Asn Tyr Glu His 
            100                 105                 110         

Met Asn Lys Glu Asn Lys Arg Gly Trp Tyr Thr Ser Asp Gly Met Phe 
        115                 120                 125             

Tyr Leu Tyr Asn Gly Asp Leu Ser His Tyr Ser Asp Gly Tyr Trp Pro 
    130                 135                 140                 

Thr Val Asn Pro Tyr Lys Met Pro Gly Thr Thr Glu Thr Asp Ala Lys 
145                 150                 155                 160 

Arg Ala Asp Ser Asp Thr Gly Lys Val Leu Pro Ser Ala Phe Val Gly 
                165                 170                 175     

Thr Ser Lys Leu Asp Asp Ala Asn Ala Thr Ala Thr Met Asp Phe Thr 
            180                 185                 190         

Asn Trp Asn Gln Thr Leu Thr Ala His Lys Ser Trp Phe Met Leu Lys 
        195                 200                 205             

Asp Lys Ile Ala Phe Leu Gly Ser Asn Ile Gln Asn Thr Ser Thr Asp 
    210                 215                 220                 

Thr Ala Ala Thr Thr Ile Asp Gln Arg Lys Leu Glu Ser Ser Asn Pro 
225                 230                 235                 240 

Tyr Lys Val Tyr Val Asn Asp Lys Glu Ala Ser Leu Thr Glu Gln Glu 
                245                 250                 255     

Lys Asp Tyr Pro Glu Thr Gln Ser Val Phe Leu Glu Ser Ser Asp Ser 
            260                 265                 270         

Lys Lys Asn Ile Gly Tyr Phe Phe Phe Lys Lys Ser Ser Ile Ser Met 
        275                 280                 285             

Ser Lys Ala Leu Gln Lys Gly Ala Trp Lys Asp Ile Asn Glu Gly Gln 
    290                 295                 300                 

Ser Asp Lys Glu Val Glu Asn Glu Phe Leu Thr Ile Ser Gln Ala His 
305                 310                 315                 320 

Lys Gln Asn Gly Asp Ser Tyr Gly Tyr Met Leu Ile Pro Asn Val Asp 
                325                 330                 335     

Arg Ala Thr Phe Asn Gln Met Ile Lys Glu Leu Glu Ser Ser Leu Ile 
            340                 345                 350         

Glu Asn Asn Glu Thr Leu Gln Ser Val Tyr Asp Ala Lys Gln Gly Val 
        355                 360                 365             

Trp Gly Ile Val Lys Tyr Asp Asp Ser Val Ser Thr Ile Ser Asn Gln 
    370                 375                 380                 

Phe Gln Val Leu Lys Arg Gly Val Tyr Thr Ile Arg Lys Glu Gly Asp 
385                 390                 395                 400 

Glu Tyr Lys Ile Ala Tyr Tyr Asn Pro Glu Thr Gln Glu Ser Ala Pro 
                405                 410                 415     

Asp Gln Glu Val Phe Lys Lys Leu Glu Gln Ala Ala Gln Pro Gln Val 
            420                 425                 430         

Gln Asn Ser Lys Glu Lys Glu Lys Ser Glu Glu Glu Lys Asn His Ser 
        435                 440                 445             

Asp Gln Lys Asn 
    450         

<210>   42
<211>   2148
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr0565 protein, which omits the natural leader peptide and sortase recognition sequences

<400>   42
Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys Glu Glu Lys 
1               5                   10                  15      

Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr Lys Asn Val 
            20                  25                  30          

Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu Ala Ile Ala 
        35                  40                  45              

Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu Glu Lys Val 
    50                  55                  60                  

Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser Gln Ala Ser 
65                  70                  75                  80  

Ser Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val Thr Asn Glu 
                85                  90                  95      

Glu Val Asn Gln Met Ile Glu Asn Arg Lys Val Asp Phe Asn Gln Asn 
            100                 105                 110         

Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile Lys Pro Asp 
        115                 120                 125             

Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr Asp Trp Ser 
    130                 135                 140                 

Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn Glu Gly Gly 
145                 150                 155                 160 

Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe Lys Leu Asp 
                165                 170                 175     

Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp Gly Val Tyr 
            180                 185                 190         

Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly His Tyr Pro 
        195                 200                 205             

Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr Leu Tyr Lys 
    210                 215                 220                 

Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn Lys Gln Pro 
225                 230                 235                 240 

Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu 
                245                 250                 255     

Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr Thr Ile Leu 
            260                 265                 270         

Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu Thr His Val 
        275                 280                 285             

Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu Leu Val Ala 
    290                 295                 300                 

Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr Gly Leu Val 
305                 310                 315                 320 

Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr Ser Leu Asp 
                325                 330                 335     

Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val Leu Asn Asp 
            340                 345                 350         

Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg Asp Gly Gln 
        355                 360                 365             

Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr Tyr His Trp 
    370                 375                 380                 

Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile Lys Phe His 
385                 390                 395                 400 

Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala Glu Glu Asn 
                405                 410                 415     

Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu Met Gly Val 
            420                 425                 430         

Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln Thr Leu Gln 
        435                 440                 445             

Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala Phe Asp Thr 
    450                 455                 460                 

Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe Phe Glu Lys 
465                 470                 475                 480 

Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp Ser Asp Phe 
                485                 490                 495     

Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro Ala Ile Phe 
            500                 505                 510         

Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly Asp Ala His 
        515                 520                 525             

Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys Asp Val Asp 
    530                 535                 540                 

Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg Phe Gly Asn 
545                 550                 555                 560 

Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp Ala Val Gly 
                565                 570                 575     

Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala Lys His Pro 
            580                 585                 590         

Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr Arg Thr Arg 
        595                 600                 605             

Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser Asn Gly Pro 
    610                 615                 620                 

Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg Val Gly Trp 
625                 630                 635                 640 

Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp Asn Ala Gly 
                645                 650                 655     

Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile Gly Glu Pro 
            660                 665                 670         

Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser Ser Tyr Phe 
        675                 680                 685             

Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe Tyr Leu Tyr 
    690                 695                 700                 

Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val His Leu Leu 
705                 710                 715                 720 

Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys Val Ala Asp 
                725                 730                 735     

Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala Ser Ser Val 
            740                 745                 750         

Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr Phe Asn Lys 
        755                 760                 765             

Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala Asn Ala Asn 
    770                 775                 780                 

Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly Thr Leu Glu 
785                 790                 795                 800 

Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg Asp Lys Ile 
                805                 810                 815     

Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys Glu Asp His 
            820                 825                 830         

Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr Tyr Glu Ile 
        835                 840                 845             

Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn Leu Val Arg 
    850                 855                 860                 

Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp Asn Gly Glu 
865                 870                 875                 880 

Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly Ser Trp Ile 
                885                 890                 895     

Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys Ser Thr Glu 
            900                 905                 910         

Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu Leu Lys Ser 
        915                 920                 925             

Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln Glu Lys Thr 
    930                 935                 940                 

Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile Gly Glu Ala 
945                 950                 955                 960 

Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp Gly Ser Arg 
                965                 970                 975     

Ala Glu Arg Pro Val Thr Trp Ser Leu Val Asp Val Ser Lys Pro Gly 
            980                 985                 990         

Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val Glu Ala Arg 
        995                 1000                1005            

Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val Lys Arg Ile 
    1010                1015                1020                

Ala Pro Asn Thr Asn Leu Asn Ser Val Asp Lys Ser Val Ser Tyr Val 
1025                1030                1035                1040

Leu Thr Asp Gly Ser Val Gln Glu Tyr Glu Val Asp Lys Trp Glu Ile 
                1045                1050                1055    

Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser Arg Ile Gln 
            1060                1065                1070        

Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala Thr Leu Val Val 
        1075                1080                1085            

Glu Glu Gly Asn Pro Ala Ala Pro Val Val Pro Thr Val Thr Val Gly 
    1090                1095                1100                

Gly Glu Ala Val Thr Gly Leu Thr Ser Arg Gln Pro Met Gln Tyr Arg 
1105                1110                1115                1120

Thr Leu Ser Tyr Gly Ala Gln Leu Pro Glu Val Thr Ala Ser Ala Glu 
                1125                1130                1135    

Asn Ala Asp Val Thr Val Leu Gln Ala Ser Ala Ala Asn Gly Met Arg 
            1140                1145                1150        

Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu Gln Thr Tyr 
        1155                1160                1165            

Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala His Leu Ser Leu 
    1170                1175                1180                

Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr Val Lys Leu 
1185                1190                1195                1200

Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala Val Leu Pro Ala 
                1205                1210                1215    

Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu Val Ala Ile Arg 
            1220                1225                1230        

Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val Thr Leu Asn Ala 
        1235                1240                1245            

Glu Tyr Glu Gly Ala Lys Gly Gln Val Glu Leu Thr Ile Gln Ala Asn 
    1250                1255                1260                

Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val Asn Val Val Thr 
1265                1270                1275                1280

Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val Thr Val Glu Tyr 
                1285                1290                1295    

Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp Gln Ala Ile Pro 
            1300                1305                1310        

Lys Glu Lys Leu Asp Ser Tyr Gln Ile Phe Glu Val Leu Gly Lys Val 
        1315                1320                1325            

Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser Val Glu Gly Ile 
    1330                1335                1340                

Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile Ala Glu Ala Pro 
1345                1350                1355                1360

Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly His Val Ser 
                1365                1370                1375    

Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu Gln Tyr Ala Lys 
            1380                1385                1390        

Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly Thr Gln Leu Thr 
        1395                1400                1405            

Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu Gln Gly Ala Asn 
    1410                1415                1420                

Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala Phe Ala Ser 
1425                1430                1435                1440

Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn Asp Lys Leu Ile 
                1445                1450                1455    

Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp Asn Arg Ser 
            1460                1465                1470        

Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp Ser Gly Ile Leu 
        1475                1480                1485            

Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe His Glu Asp His 
    1490                1495                1500                

Gly Val Gly Ala Pro Lys Ser Tyr Val Ile Glu Tyr Tyr Val Gly Lys 
1505                1510                1515                1520

Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val Gly Asn Glu Asp 
                1525                1530                1535    

His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val Thr Asn Leu Lys 
            1540                1545                1550        

Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His Phe Ser Phe Asp 
        1555                1560                1565            

Lys Val Glu Thr Tyr Ala Ile Arg Ile Arg Met Val Lys Ala Asp Asn 
    1570                1575                1580                

Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe Ala Lys Gln Val 
1585                1590                1595                1600

Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val Asp Gly Lys Asp 
                1605                1610                1615    

Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu Glu Ser Val 
            1620                1625                1630        

Asp Gly Lys Val Pro Ala Val Thr Ala Asn Val Ser Asn Asn Gly Leu 
        1635                1640                1645            

Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro Val Arg Val Ile 
    1650                1655                1660                

Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg Leu His Phe 
1665                1670                1675                1680

Thr Lys Asp Lys Asn Leu Leu Ser His Lys Pro Val Ala Ala Val Lys 
                1685                1690                1695    

Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu Leu Pro Thr Lys 
            1700                1705                1710        

Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr Lys Asp Leu 
        1715                1720                1725            

Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu Thr Lys Ala Gly 
    1730                1735                1740                

Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn Leu Val Ala Glu 
1745                1750                1755                1760

Val Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr Leu Ser Asp Asn 
                1765                1770                1775    

Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser Ala Thr Asn 
            1780                1785                1790        

Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr Leu Asn Asp Gly 
        1795                1800                1805            

Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro Thr Pro Ser 
    1810                1815                1820                

Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg Glu Asn Gly Lys 
1825                1830                1835                1840

Ile Val Glu Arg Thr Val Ala Gln Ala Lys Leu His Phe Phe Ala Asp 
                1845                1850                1855    

Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu Arg Tyr Val Gly 
            1860                1865                1870        

Pro Gly Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln Ala Tyr Glu 
        1875                1880                1885            

Ser Gly His Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala Val Pro Tyr 
    1890                1895                1900                

Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn Val Thr Phe 
1905                1910                1915                1920

Lys Ala Val Lys Ala Lys Val Met Arg Trp Arg Met Glu Arg Lys Ala 
                1925                1930                1935    

Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe Leu Ala Pro Ser 
            1940                1945                1950        

Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu Val Asp Gly Lys 
        1955                1960                1965            

Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln Ile Thr Tyr 
    1970                1975                1980                

Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn Asn Gln Val Ala 
1985                1990                1995                2000

Ser Thr Val Val Asp Ser Gly Glu Asp Ser Leu Pro Val Leu Val Arg 
                2005                2010                2015    

Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg Ile Gln Leu 
            2020                2025                2030        

Thr Lys Glu Lys Pro Val Ser Ala Val Gln Glu Asp Leu Pro Lys Leu 
        2035                2040                2045            

Glu Phe Val Glu Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys Lys Asp 
    2050                2055                2060                

Ser Thr Leu Tyr Leu Gly Glu Thr Arg Val Glu Gln Glu Gly Lys Val 
2065                2070                2075                2080

Gly Lys Glu Arg Ile Phe Thr Val Ile Asn Pro Asp Gly Ser Lys Glu 
                2085                2090                2095    

Glu Lys Leu Arg Glu Val Val Glu Val Pro Thr Asp Arg Ile Val Leu 
            2100                2105                2110        

Val Gly Thr Lys Pro Val Ala Gln Glu Ala Lys Lys Pro Gln Val Ser 
        2115                2120                2125            

Glu Lys Ala Asp Thr Lys Pro Ile Asp Ser Ser Glu Ala Asp Gln Thr 
    2130                2135                2140                

Asn Lys Ala Gln 
2145            

<210>   43
<211>   1063
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   shortened version of spr0565

<400>   43
Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys Glu Glu Lys 
1               5                   10                  15      

Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr Lys Asn Val 
            20                  25                  30          

Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu Ala Ile Ala 
        35                  40                  45              

Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu Glu Lys Val 
    50                  55                  60                  

Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser Gln Ala Ser 
65                  70                  75                  80  

Ser Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val Thr Asn Glu 
                85                  90                  95      

Glu Val Asn Gln Met Ile Glu Asn Arg Lys Val Asp Phe Asn Gln Asn 
            100                 105                 110         

Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile Lys Pro Asp 
        115                 120                 125             

Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr Asp Trp Ser 
    130                 135                 140                 

Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn Glu Gly Gly 
145                 150                 155                 160 

Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe Lys Leu Asp 
                165                 170                 175     

Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp Gly Val Tyr 
            180                 185                 190         

Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly His Tyr Pro 
        195                 200                 205             

Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr Leu Tyr Lys 
    210                 215                 220                 

Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn Lys Gln Pro 
225                 230                 235                 240 

Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu 
                245                 250                 255     

Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr Thr Ile Leu 
            260                 265                 270         

Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu Thr His Val 
        275                 280                 285             

Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu Leu Val Ala 
    290                 295                 300                 

Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr Gly Leu Val 
305                 310                 315                 320 

Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr Ser Leu Asp 
                325                 330                 335     

Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val Leu Asn Asp 
            340                 345                 350         

Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg Asp Gly Gln 
        355                 360                 365             

Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr Tyr His Trp 
    370                 375                 380                 

Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile Lys Phe His 
385                 390                 395                 400 

Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala Glu Glu Asn 
                405                 410                 415     

Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu Met Gly Val 
            420                 425                 430         

Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln Thr Leu Gln 
        435                 440                 445             

Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala Phe Asp Thr 
    450                 455                 460                 

Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe Phe Glu Lys 
465                 470                 475                 480 

Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp Ser Asp Phe 
                485                 490                 495     

Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro Ala Ile Phe 
            500                 505                 510         

Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly Asp Ala His 
        515                 520                 525             

Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys Asp Val Asp 
    530                 535                 540                 

Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg Phe Gly Asn 
545                 550                 555                 560 

Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp Ala Val Gly 
                565                 570                 575     

Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala Lys His Pro 
            580                 585                 590         

Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr Arg Thr Arg 
        595                 600                 605             

Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser Asn Gly Pro 
    610                 615                 620                 

Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg Val Gly Trp 
625                 630                 635                 640 

Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp Asn Ala Gly 
                645                 650                 655     

Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile Gly Glu Pro 
            660                 665                 670         

Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser Ser Tyr Phe 
        675                 680                 685             

Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe Tyr Leu Tyr 
    690                 695                 700                 

Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val His Leu Leu 
705                 710                 715                 720 

Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys Val Ala Asp 
                725                 730                 735     

Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala Ser Ser Val 
            740                 745                 750         

Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr Phe Asn Lys 
        755                 760                 765             

Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala Asn Ala Asn 
    770                 775                 780                 

Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly Thr Leu Glu 
785                 790                 795                 800 

Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg Asp Lys Ile 
                805                 810                 815     

Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys Glu Asp His 
            820                 825                 830         

Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr Tyr Glu Ile 
        835                 840                 845             

Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn Leu Val Arg 
    850                 855                 860                 

Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp Asn Gly Glu 
865                 870                 875                 880 

Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly Ser Trp Ile 
                885                 890                 895     

Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys Ser Thr Glu 
            900                 905                 910         

Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu Leu Lys Ser 
        915                 920                 925             

Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln Glu Lys Thr 
    930                 935                 940                 

Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile Gly Glu Ala 
945                 950                 955                 960 

Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp Gly Ser Arg 
                965                 970                 975     

Ala Glu Arg Pro Val Thr Trp Ser Leu Val Asp Val Ser Lys Pro Gly 
            980                 985                 990         

Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val Glu Ala Arg 
        995                 1000                1005            

Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val Lys Arg Ile 
    1010                1015                1020                

Ala Pro Asn Thr Asn Leu Asn Ser Val Asp Lys Ser Val Ser Tyr Val 
1025                1030                1035                1040

Leu Thr Asp Gly Ser Val Gln Glu Tyr Glu Val Asp Lys Trp Glu Ile 
                1045                1050                1055    

Ala Glu Glu Asp Lys Ala Lys 
            1060            

<210>   44
<211>   1093
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   shortened version of spr0565

<400>   44
Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser Arg Ile 
1               5                   10                  15      

Gln Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala Thr Leu Val 
            20                  25                  30          

Val Glu Glu Gly Asn Pro Ala Ala Pro Val Val Pro Thr Val Thr Val 
        35                  40                  45              

Gly Gly Glu Ala Val Thr Gly Leu Thr Ser Arg Gln Pro Met Gln Tyr 
    50                  55                  60                  

Arg Thr Leu Ser Tyr Gly Ala Gln Leu Pro Glu Val Thr Ala Ser Ala 
65                  70                  75                  80  

Glu Asn Ala Asp Val Thr Val Leu Gln Ala Ser Ala Ala Asn Gly Met 
                85                  90                  95      

Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu Gln Thr 
            100                 105                 110         

Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala His Leu Ser 
        115                 120                 125             

Leu Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr Val Lys 
    130                 135                 140                 

Leu Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala Val Leu Pro 
145                 150                 155                 160 

Ala Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu Val Ala Ile 
                165                 170                 175     

Arg Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val Thr Leu Asn 
            180                 185                 190         

Ala Glu Tyr Glu Gly Ala Lys Gly Gln Val Glu Leu Thr Ile Gln Ala 
        195                 200                 205             

Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val Asn Val Val 
    210                 215                 220                 

Thr Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val Thr Val Glu 
225                 230                 235                 240 

Tyr Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp Gln Ala Ile 
                245                 250                 255     

Pro Lys Glu Lys Leu Asp Ser Tyr Gln Ile Phe Glu Val Leu Gly Lys 
            260                 265                 270         

Val Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser Val Glu Gly 
        275                 280                 285             

Ile Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile Ala Glu Ala 
    290                 295                 300                 

Pro Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly His Val 
305                 310                 315                 320 

Ser Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu Gln Tyr Ala 
                325                 330                 335     

Lys Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly Thr Gln Leu 
            340                 345                 350         

Thr Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu Gln Gly Ala 
        355                 360                 365             

Asn Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala Phe Ala 
    370                 375                 380                 

Ser Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn Asp Lys Leu 
385                 390                 395                 400 

Ile Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp Asn Arg 
                405                 410                 415     

Ser Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp Ser Gly Ile 
            420                 425                 430         

Leu Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe His Glu Asp 
        435                 440                 445             

His Gly Val Gly Ala Pro Lys Ser Tyr Val Ile Glu Tyr Tyr Val Gly 
    450                 455                 460                 

Lys Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val Gly Asn Glu 
465                 470                 475                 480 

Asp His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val Thr Asn Leu 
                485                 490                 495     

Lys Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His Phe Ser Phe 
            500                 505                 510         

Asp Lys Val Glu Thr Tyr Ala Ile Arg Ile Arg Met Val Lys Ala Asp 
        515                 520                 525             

Asn Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe Ala Lys Gln 
    530                 535                 540                 

Val Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val Asp Gly Lys 
545                 550                 555                 560 

Asp Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu Glu Ser 
                565                 570                 575     

Val Asp Gly Lys Val Pro Ala Val Thr Ala Asn Val Ser Asn Asn Gly 
            580                 585                 590         

Leu Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro Val Arg Val 
        595                 600                 605             

Ile Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg Leu His 
    610                 615                 620                 

Phe Thr Lys Asp Lys Asn Leu Leu Ser His Lys Pro Val Ala Ala Val 
625                 630                 635                 640 

Lys Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu Leu Pro Thr 
                645                 650                 655     

Lys Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr Lys Asp 
            660                 665                 670         

Leu Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu Thr Lys Ala 
        675                 680                 685             

Gly Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn Leu Val Ala 
    690                 695                 700                 

Glu Val Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr Leu Ser Asp 
705                 710                 715                 720 

Asn Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser Ala Thr 
                725                 730                 735     

Asn Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr Leu Asn Asp 
            740                 745                 750         

Gly Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro Thr Pro 
        755                 760                 765             

Ser Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg Glu Asn Gly 
    770                 775                 780                 

Lys Ile Val Glu Arg Thr Val Ala Gln Ala Lys Leu His Phe Phe Ala 
785                 790                 795                 800 

Asp Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu Arg Tyr Val 
                805                 810                 815     

Gly Pro Gly Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln Ala Tyr 
            820                 825                 830         

Glu Ser Gly His Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala Val Pro 
        835                 840                 845             

Tyr Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn Val Thr 
    850                 855                 860                 

Phe Lys Ala Val Lys Ala Lys Val Met Arg Trp Arg Met Glu Arg Lys 
865                 870                 875                 880 

Ala Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe Leu Ala Pro 
                885                 890                 895     

Ser Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu Val Asp Gly 
            900                 905                 910         

Lys Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln Ile Thr 
        915                 920                 925             

Tyr Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn Asn Gln Val 
    930                 935                 940                 

Ala Ser Thr Val Val Asp Ser Gly Glu Asp Ser Leu Pro Val Leu Val 
945                 950                 955                 960 

Arg Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg Ile Gln 
                965                 970                 975     

Leu Thr Lys Glu Lys Pro Val Ser Ala Val Gln Glu Asp Leu Pro Lys 
            980                 985                 990         

Leu Glu Phe Val Glu Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys Lys 
        995                 1000                1005            

Asp Ser Thr Leu Tyr Leu Gly Glu Thr Arg Val Glu Gln Glu Gly Lys 
    1010                1015                1020                

Val Gly Lys Glu Arg Ile Phe Thr Val Ile Asn Pro Asp Gly Ser Lys 
1025                1030                1035                1040

Glu Glu Lys Leu Arg Glu Val Val Glu Val Pro Thr Asp Arg Ile Val 
                1045                1050                1055    

Leu Val Gly Thr Lys Pro Val Ala Gln Glu Ala Lys Lys Pro Gln Val 
            1060                1065                1070        

Ser Glu Lys Ala Asp Thr Lys Pro Ile Asp Ser Ser Glu Ala Asp Gln 
        1075                1080                1085            

Thr Asn Lys Ala Gln 
    1090            

<210>   45
<211>   2233
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   variant form of spr0565

<400>   45
Met Gly Lys Gly His Trp Asn Arg Lys Arg Val Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Phe Ala Val Gly Ala Cys Ser Val Met Ile Gly Thr Cys Ala Val Leu 
            20                  25                  30          

Leu Gly Gly Asn Ile Ala Gly Glu Ser Val Val Tyr Ala Asp Glu Thr 
        35                  40                  45              

Leu Ile Thr His Thr Ala Glu Lys Pro Lys Glu Glu Lys Met Ile Val 
    50                  55                  60                  

Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr Lys Asn Ile Val Glu Arg 
65                  70                  75                  80  

Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu Ala Ile Ala Ser Glu Lys 
                85                  90                  95      

Lys Glu Asp Glu Ala Val Thr Pro Lys Glu Glu Lys Val Ser Ala Lys 
            100                 105                 110         

Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser Gln Ala Ser Asn Gln Glu 
        115                 120                 125             

Lys Pro Leu Lys Glu Asp Ala Lys Ala Val Thr Asn Glu Glu Val Asn 
    130                 135                 140                 

Gln Met Ile Glu Asp Arg Lys Val Asp Phe Asn Gln Asn Trp Tyr Phe 
145                 150                 155                 160 

Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile Lys Pro Asp Ala Asp Val 
                165                 170                 175     

Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr Asp Trp Ser Ile Phe Asn 
            180                 185                 190         

Asp Phe Asp His Glu Ser Pro Ala Gln Asn Glu Gly Gly Gln Leu Asn 
        195                 200                 205             

Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe Lys Leu Asp Glu Lys Asp 
    210                 215                 220                 

Leu Lys Lys Asn Val Arg Leu Thr Phe Asp Gly Val Tyr Met Asp Ser 
225                 230                 235                 240 

Gln Val Tyr Val Asn Gly Gln Leu Val Gly His Tyr Pro Asn Gly Tyr 
                245                 250                 255     

Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr Leu Gln Lys Asp Gly Arg 
            260                 265                 270         

Glu Asn Val Ile Ala Val His Ala Val Asn Lys Gln Pro Ser Ser Arg 
        275                 280                 285             

Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu Gln Val Thr 
    290                 295                 300                 

Asp Lys Val His Val Glu Lys Asn Gly Thr Thr Ile Leu Thr Pro Lys 
305                 310                 315                 320 

Leu Glu Glu Gln Gln His Gly Lys Val Glu Thr His Val Thr Ser Lys 
                325                 330                 335     

Ile Val Asn Thr Asp Asp Lys Asp His Glu Leu Val Ala Glu Tyr Gln 
            340                 345                 350         

Ile Val Glu Arg Gly Gly His Ala Val Thr Gly Leu Val Arg Thr Ala 
        355                 360                 365             

Ser Arg Thr Leu Lys Ala His Glu Ser Thr Ser Leu Asp Ala Ile Leu 
    370                 375                 380                 

Glu Val Glu Arg Pro Lys Leu Trp Thr Val Leu Asn Asp Lys Pro Ala 
385                 390                 395                 400 

Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg Asp Gly Gln Leu Val Asp 
                405                 410                 415     

Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr Tyr His Trp Thr Pro Asn 
            420                 425                 430         

Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile Lys Phe His Gly Val Ser 
        435                 440                 445             

Leu His His Asp His Gly Ala Leu Gly Ala Glu Glu Asn Tyr Lys Ala 
    450                 455                 460                 

Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu Met Gly Val Asn Ser Ile 
465                 470                 475                 480 

Arg Thr Thr His Asn Pro Ala Ser Glu Gln Thr Leu Gln Ile Ala Ala 
                485                 490                 495     

Glu Leu Gly Leu Leu Val Gln Glu Glu Ala Phe Asp Thr Trp Tyr Gly 
            500                 505                 510         

Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe Phe Glu Lys Asp Ala Thr 
        515                 520                 525             

His Pro Glu Ala Arg Lys Gly Glu Lys Trp Ser Asp Phe Asp Leu Arg 
    530                 535                 540                 

Thr Met Val Glu Arg Gly Lys Asn Asn Pro Ala Ile Phe Met Trp Ser 
545                 550                 555                 560 

Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly Asp Ala His Ser Leu Ala 
                565                 570                 575     

Thr Val Lys Arg Leu Val Lys Val Ile Lys Asp Val Asp Lys Thr Arg 
            580                 585                 590         

Tyr Val Thr Met Gly Ala Asp Lys Phe Arg Phe Gly Asn Gly Ser Gly 
        595                 600                 605             

Gly His Glu Lys Ile Ala Asp Glu Leu Asp Ala Val Gly Phe Asn Tyr 
    610                 615                 620                 

Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala Lys His Pro Lys Trp Leu 
625                 630                 635                 640 

Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr Arg Thr Arg Gly Ser Tyr 
                645                 650                 655     

Tyr Arg Pro Glu Arg Glu Leu Lys His Ser Asn Gly Pro Glu Arg Asn 
            660                 665                 670         

Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg Val Gly Trp Gly Lys Thr 
        675                 680                 685             

Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp Asn Ala Gly Tyr Ala Gly 
    690                 695                 700                 

Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile Gly Glu Pro Thr Pro Trp 
705                 710                 715                 720 

His Asn Gln Asn Gln Thr Pro Val Lys Ser Ser Tyr Phe Gly Ile Val 
                725                 730                 735     

Asp Thr Ala Gly Ile Pro Lys His Asp Phe Tyr Leu Tyr Gln Ser Gln 
            740                 745                 750         

Trp Val Ser Val Lys Lys Lys Pro Met Val His Leu Leu Pro His Trp 
        755                 760                 765             

Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys Val Ala Asp Ser Glu Gly 
    770                 775                 780                 

Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala Ser Ser Val Glu Leu Phe 
785                 790                 795                 800 

Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr Phe Asn Lys Lys Gln Thr 
                805                 810                 815     

Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala Asn Ala Asn Glu Leu Tyr 
            820                 825                 830         

Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly Thr Leu Glu Ala Ile Ala 
        835                 840                 845             

Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg Asp Lys Ile Thr Thr Ala 
    850                 855                 860                 

Gly Lys Pro Ala Ala Val Arg Leu Ile Lys Glu Asp His Ala Ile Ala 
865                 870                 875                 880 

Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr Tyr Glu Ile Val Asp Ser 
                885                 890                 895     

Gln Gly Asn Val Val Pro Thr Ala Asn Asn Leu Val Arg Phe Gln Leu 
            900                 905                 910         

His Gly Gln Gly Gln Leu Val Gly Val Asp Asn Gly Glu Gln Ala Ser 
        915                 920                 925             

Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly Ser Trp Ile Arg Lys Ala 
    930                 935                 940                 

Phe Asn Gly Lys Gly Val Ala Ile Val Lys Ser Thr Glu Gln Ala Gly 
945                 950                 955                 960 

Lys Phe Thr Leu Thr Ala His Ser Asp Leu Leu Lys Ser Asn Gln Val 
                965                 970                 975     

Thr Val Phe Thr Gly Lys Lys Glu Gly Gln Glu Lys Thr Val Leu Gly 
            980                 985                 990         

Thr Glu Val Pro Lys Val Gln Thr Ile Ile Gly Glu Ala Pro Glu Met 
        995                 1000                1005            

Pro Thr Thr Val Pro Phe Val Tyr Ser Asp Gly Ser Arg Ala Glu Arg 
    1010                1015                1020                

Pro Val Thr Trp Ser Ser Val Asp Val Ser Lys Pro Gly Ile Val Thr 
1025                1030                1035                1040

Val Lys Gly Met Ala Asp Gly Arg Glu Val Glu Ala Arg Val Glu Val 
                1045                1050                1055    

Ile Ala Leu Lys Ser Glu Leu Pro Val Val Lys Arg Ile Ala Pro Asn 
            1060                1065                1070        

Thr Asp Leu Asn Ser Val Asp Lys Ser Val Ser Tyr Val Leu Ile Asp 
        1075                1080                1085            

Gly Ser Val Glu Glu Tyr Glu Val Asp Lys Trp Glu Ile Ala Glu Glu 
    1090                1095                1100                

Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser Arg Ile Gln Ala Thr Gly 
1105                1110                1115                1120

Tyr Leu Glu Gly Gln Pro Ile His Ala Thr Leu Val Val Glu Glu Gly 
                1125                1130                1135    

Asn Pro Ala Ala Pro Ala Val Pro Thr Val Thr Val Gly Gly Glu Ala 
            1140                1145                1150        

Val Thr Gly Leu Thr Ser Gln Lys Pro Met Gln Tyr Arg Thr Leu Ala 
        1155                1160                1165            

Tyr Gly Ala Lys Leu Pro Glu Val Thr Ala Ser Ala Lys Asn Ala Ala 
    1170                1175                1180                

Val Thr Val Leu Gln Ala Ser Ala Ala Asn Gly Met Arg Ala Ser Ile 
1185                1190                1195                1200

Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu Gln Thr Tyr Ala Ile Gln 
                1205                1210                1215    

Phe Leu Glu Glu Ala Pro Lys Ile Ala His Leu Ser Leu Gln Val Glu 
            1220                1225                1230        

Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr Val Lys Leu Ser Val Arg 
        1235                1240                1245            

Ala His Tyr Gln Asp Gly Thr Gln Ala Val Leu Pro Ala Asp Lys Val 
    1250                1255                1260                

Thr Phe Ser Thr Ser Gly Glu Gly Glu Val Ala Ile Arg Lys Gly Met 
1265                1270                1275                1280

Leu Glu Leu His Lys Pro Gly Ala Val Thr Leu Asn Ala Glu Tyr Glu 
                1285                1290                1295    

Gly Ala Lys Asp Gln Val Glu Leu Thr Ile Gln Ala Asn Thr Glu Lys 
            1300                1305                1310        

Lys Ile Ala Gln Ser Ile Arg Pro Val Asn Val Val Thr Asp Leu His 
        1315                1320                1325            

Gln Glu Pro Ser Leu Pro Ala Thr Val Thr Val Glu Tyr Asp Lys Gly 
    1330                1335                1340                

Phe Pro Lys Thr His Lys Val Thr Trp Gln Ala Ile Pro Lys Glu Lys 
1345                1350                1355                1360

Leu Asp Ser Tyr Gln Thr Phe Glu Val Leu Gly Lys Val Glu Gly Ile 
                1365                1370                1375    

Asp Leu Glu Ala Arg Ala Lys Val Ser Val Glu Gly Ile Val Ser Val 
            1380                1385                1390        

Glu Glu Val Ser Val Thr Thr Pro Ile Ala Glu Ala Pro Gln Leu Pro 
        1395                1400                1405            

Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly His Val Ser Ser Ala Lys 
    1410                1415                1420                

Val Ala Trp Asp Ala Ile Arg Pro Glu Gln Tyr Ala Lys Glu Gly Val 
1425                1430                1435                1440

Phe Thr Val Asn Gly Arg Leu Glu Gly Thr Gln Leu Thr Thr Lys Leu 
                1445                1450                1455    

His Val Arg Val Ser Ala Gln Thr Glu Gln Gly Ala Asn Ile Ser Asp 
            1460                1465                1470        

Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala Phe Ala Ser Asp Ser Asn 
        1475                1480                1485            

Pro Ser Asp Pro Val Ser Asn Val Asn Asp Lys Leu Ile Ser Tyr Asn 
    1490                1495                1500                

Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp Asn Arg Thr Asn Pro Glu 
1505                1510                1515                1520

Ala Ser Val Gly Val Leu Phe Gly Asp Ser Gly Ile Leu Ser Lys Arg 
                1525                1530                1535    

Ser Val Asp Asn Leu Ser Val Gly Phe His Glu Asp His Gly Val Gly 
            1540                1545                1550        

Val Pro Lys Ser Tyr Val Ile Glu Tyr Tyr Val Gly Lys Thr Val Pro 
        1555                1560                1565            

Thr Ala Pro Lys Asn Pro Ser Phe Val Gly Asn Glu Asp His Val Phe 
    1570                1575                1580                

Asn Asp Ser Ala Asn Trp Lys Pro Val Thr Asn Leu Lys Ala Pro Ala 
1585                1590                1595                1600

Gln Leu Lys Ala Gly Glu Met Asn His Phe Ser Phe Asp Lys Val Glu 
                1605                1610                1615    

Thr Tyr Ala Val Arg Ile Arg Met Val Lys Ala Asp Asn Lys Arg Gly 
            1620                1625                1630        

Thr Ser Ile Thr Glu Val Gln Ile Phe Ala Lys Gln Val Ala Ala Ala 
        1635                1640                1645            

Lys Gln Gly Gln Thr Arg Ile Gln Val Asp Gly Lys Asp Leu Ala Asn 
    1650                1655                1660                

Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu Glu Ser Val Asp Gly Lys 
1665                1670                1675                1680

Val Pro Ala Val Thr Ala Ser Val Ser Asn Asn Gly Leu Ala Thr Val 
                1685                1690                1695    

Val Pro Ser Val Arg Glu Gly Glu Pro Val Arg Val Ile Ala Lys Ala 
            1700                1705                1710        

Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg Leu His Phe Thr Lys Asp 
        1715                1720                1725            

Lys Ser Leu Leu Ser His Lys Pro Val Ala Ala Val Lys Gln Ala Arg 
    1730                1735                1740                

Leu Leu Gln Val Gly Gln Ala Leu Glu Leu Pro Thr Lys Val Pro Val 
1745                1750                1755                1760

Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr Lys Asp Leu Thr Val Glu 
                1765                1770                1775    

Trp Glu Glu Val Pro Ala Glu Asn Leu Thr Lys Ala Gly Gln Phe Thr 
            1780                1785                1790        

Val Arg Gly Arg Val Leu Gly Ser Asn Leu Val Ala Glu Ile Thr Val 
        1795                1800                1805            

Arg Val Thr Asp Lys Leu Gly Glu Thr Leu Ser Asp Asn Pro Asn Tyr 
    1810                1815                1820                

Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser Ala Thr Asn Asp Ile Asp 
1825                1830                1835                1840

Lys Asn Ser His Asp Arg Val Asp Tyr Leu Asn Asp Gly Asp His Ser 
                1845                1850                1855    

Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro Thr Pro Ser Ser Asn Pro 
            1860                1865                1870        

Glu Val Ser Ala Gly Val Ile Phe Arg Glu Asn Gly Lys Ile Val Glu 
        1875                1880                1885            

Arg Thr Val Thr Gln Gly Lys Val Gln Phe Phe Ala Asp Ser Gly Thr 
    1890                1895                1900                

Asp Ala Pro Ser Lys Leu Val Leu Glu Arg Tyr Val Gly Pro Glu Phe 
1905                1910                1915                1920

Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln Ala Tyr Asp Ala Asp His 
                1925                1930                1935    

Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala Val Pro Tyr Arg Ala Asp 
            1940                1945                1950        

Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn Val Thr Phe Lys Ala Ile 
        1955                1960                1965            

Lys Ala Lys Ala Met Arg Trp Arg Met Glu Arg Lys Ala Asp Lys Ser 
    1970                1975                1980                

Gly Val Ala Met Ile Glu Met Thr Phe Leu Ala Pro Ser Glu Leu Pro 
1985                1990                1995                2000

Gln Glu Ser Thr Gln Ser Lys Ile Leu Val Asp Gly Lys Glu Leu Ala 
                2005                2010                2015    

Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln Ile Thr Tyr Lys Gly Gln 
            2020                2025                2030        

Arg Pro Lys Val Ser Val Glu Glu Asn Asn Gln Val Ala Ser Thr Val 
        2035                2040                2045            

Val Asp Ser Gly Glu Asp Ser Phe Pro Val Leu Val Arg Leu Val Ser 
    2050                2055                2060                

Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg Ile His Leu Thr Lys Glu 
2065                2070                2075                2080

Lys Pro Val Ser Glu Lys Thr Val Ala Ala Val Gln Glu Asp Leu Pro 
                2085                2090                2095    

Lys Ile Glu Phe Val Glu Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys 
            2100                2105                2110        

Lys Asp Ser Thr Leu Tyr Leu Gly Glu Thr Arg Val Glu Gln Glu Gly 
        2115                2120                2125            

Lys Val Gly Lys Glu Arg Ile Phe Thr Ala Ile Asn Pro Asp Gly Ser 
    2130                2135                2140                

Lys Glu Glu Lys Leu Arg Glu Val Val Glu Val Pro Thr Asp Arg Ile 
2145                2150                2155                2160

Val Leu Val Gly Thr Lys Pro Val Ala Gln Glu Ala Lys Lys Pro Gln 
                2165                2170                2175    

Val Ser Glu Lys Ala Asp Thr Lys Pro Ile Asp Ser Ser Glu Ala Ser 
            2180                2185                2190        

Gln Thr Asn Lys Ala Gln Leu Pro Ser Thr Gly Ser Ala Ala Ser Gln 
        2195                2200                2205            

Ala Ala Val Ala Ala Gly Leu Thr Leu Leu Gly Leu Ser Ala Gly Leu 
    2210                2215                2220                

Val Val Thr Lys Gly Lys Lys Glu Asp 
2225                2230            

<210>   46
<211>   218
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   fragment of SEQ ID NO: 26 which omits the natural leader peptide sequence

<400>   46
Ala Leu Ile Phe Asn Thr Gln Ile Arg Asn Ile Phe Ile Val Trp Asn 
1               5                   10                  15      

Thr Asn Lys Tyr Gln Val Ser Gln Val Ser Lys Glu Lys Leu Glu Glu 
            20                  25                  30          

Asn Gln Asp Thr Glu Gly Asn Phe Asp Phe Asp Ser Val Lys Ala Ile 
        35                  40                  45              

Ser Ser Glu Ala Val Leu Thr Ser Gln Trp Asp Ala Gln Lys Leu Pro 
    50                  55                  60                  

Val Ile Gly Gly Ile Ala Ile Pro Glu Leu Glu Met Asn Leu Pro Ile 
65                  70                  75                  80  

Phe Lys Gly Leu Asp Asn Val Asn Leu Phe Tyr Gly Ala Gly Thr Met 
                85                  90                  95      

Lys Arg Glu Gln Val Met Gly Glu Gly Asn Tyr Ser Leu Ala Ser His 
            100                 105                 110         

His Ile Phe Gly Val Asp Asn Ala Asn Lys Met Leu Phe Ser Pro Leu 
        115                 120                 125             

Asp Asn Ala Lys Asn Gly Met Lys Ile Tyr Leu Thr Asp Lys Asn Lys 
    130                 135                 140                 

Val Tyr Thr Tyr Glu Ile Arg Glu Val Lys Arg Val Thr Pro Asp Arg 
145                 150                 155                 160 

Val Asp Glu Val Asp Asp Arg Asp Gly Val Asn Glu Ile Thr Leu Val 
                165                 170                 175     

Thr Cys Glu Asp Leu Ala Ala Thr Glu Arg Ile Ile Val Lys Gly Asp 
            180                 185                 190         

Leu Lys Glu Thr Lys Asp Tyr Ser Gln Thr Ser Asp Glu Ile Leu Thr 
        195                 200                 205             

Ala Phe Asn Gln Pro Tyr Lys Gln Phe Tyr 
    210                 215             

<210>   47
<211>   165
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr1345

<400>   47
Val Pro Lys Thr Ala Thr Ser Thr Glu Thr Lys Thr Ile Thr Arg Ile 
1               5                   10                  15      

Ile His Tyr Val Asp Lys Val Thr Asn Gln Asn Val Lys Glu Asp Val 
            20                  25                  30          

Val Gln Pro Val Thr Leu Ser Arg Thr Lys Thr Glu Asn Lys Val Thr 
        35                  40                  45              

Gly Val Val Thr Tyr Gly Glu Trp Thr Thr Gly Asn Trp Asp Glu Val 
    50                  55                  60                  

Ile Ser Gly Lys Ile Asp Lys Tyr Lys Asp Pro Asp Ile Pro Thr Val 
65                  70                  75                  80  

Glu Ser Gln Glu Val Thr Ser Asp Ser Ser Asp Lys Glu Ile Thr Val 
                85                  90                  95      

Arg Tyr Asp Arg Leu Ser Thr Pro Glu Lys Pro Ile Pro Gln Pro Asn 
            100                 105                 110         

Pro Glu His Pro Ser Val Pro Thr Pro Asn Pro Glu Leu Pro Asn Gln 
        115                 120                 125             

Glu Thr Pro Thr Pro Asp Lys Pro Thr Pro Glu Pro Gly Thr Pro Lys 
    130                 135                 140                 

Thr Glu Thr Pro Val Asn Pro Asp Pro Glu Val Pro Thr Tyr Glu Thr 
145                 150                 155                 160 

Gly Lys Arg Glu Glu 
                165 

<210>   48
<211>   680
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Fragment of SEQ ID NO: 30 which omits the natural leader peptide sequence

<400>   48
Ala Ser Asp Gly Thr Trp Gln Gly Lys Gln Tyr Leu Lys Glu Asp Gly 
1               5                   10                  15      

Ser Gln Ala Ala Asn Glu Trp Val Phe Asp Thr His Tyr Gln Ser Trp 
            20                  25                  30          

Phe Tyr Ile Lys Ala Asp Ala Asn Tyr Ala Glu Asn Glu Trp Leu Lys 
        35                  40                  45              

Gln Gly Asp Asp Tyr Phe Tyr Leu Lys Ser Gly Gly Tyr Met Ala Lys 
    50                  55                  60                  

Ser Glu Trp Val Glu Asp Lys Gly Ala Phe Tyr Tyr Leu Asp Gln Asp 
65                  70                  75                  80  

Gly Lys Met Lys Arg Asn Ala Trp Val Gly Thr Ser Tyr Val Gly Ala 
                85                  90                  95      

Thr Gly Ala Lys Val Ile Glu Asp Trp Val Tyr Asp Ser Gln Tyr Asp 
            100                 105                 110         

Ala Trp Phe Tyr Ile Lys Ala Asp Gly Gln His Ala Glu Lys Glu Trp 
        115                 120                 125             

Leu Gln Ile Lys Gly Lys Asp Tyr Tyr Phe Lys Ser Gly Gly Tyr Leu 
    130                 135                 140                 

Leu Thr Ser Gln Trp Ile Asn Gln Ala Tyr Val Asn Ala Ser Gly Ala 
145                 150                 155                 160 

Lys Val Gln Gln Gly Trp Leu Phe Asp Lys Gln Tyr Gln Ser Trp Phe 
                165                 170                 175     

Tyr Ile Lys Glu Asn Gly Asn Tyr Ala Asp Lys Glu Trp Ile Phe Glu 
            180                 185                 190         

Asn Gly His Tyr Tyr Tyr Leu Lys Ser Gly Gly Tyr Met Ala Ala Asn 
        195                 200                 205             

Glu Trp Ile Trp Asp Lys Glu Ser Trp Phe Tyr Leu Lys Phe Asp Gly 
    210                 215                 220                 

Lys Ile Ala Glu Lys Glu Trp Val Tyr Asp Ser His Ser Gln Ala Trp 
225                 230                 235                 240 

Tyr Tyr Phe Lys Ser Gly Gly Tyr Met Ala Ala Asn Glu Trp Ile Trp 
                245                 250                 255     

Asp Lys Glu Ser Trp Phe Tyr Leu Lys Phe Asp Gly Lys Met Ala Glu 
            260                 265                 270         

Lys Glu Trp Val Tyr Asp Ser His Ser Gln Ala Trp Tyr Tyr Phe Lys 
        275                 280                 285             

Ser Gly Gly Tyr Met Thr Ala Asn Glu Trp Ile Trp Asp Lys Glu Ser 
    290                 295                 300                 

Trp Phe Tyr Leu Lys Ser Asp Gly Lys Ile Ala Glu Lys Glu Trp Val 
305                 310                 315                 320 

Tyr Asp Ser His Ser Gln Ala Trp Tyr Tyr Phe Lys Ser Gly Gly Tyr 
                325                 330                 335     

Met Thr Ala Asn Glu Trp Ile Trp Asp Lys Glu Ser Trp Phe Tyr Leu 
            340                 345                 350         

Lys Ser Asp Gly Lys Met Ala Glu Lys Glu Trp Val Tyr Asp Ser His 
        355                 360                 365             

Ser Gln Ala Trp Tyr Tyr Phe Lys Ser Gly Gly Tyr Met Ala Lys Asn 
    370                 375                 380                 

Glu Thr Val Asp Gly Tyr Gln Leu Gly Ser Asp Gly Lys Trp Leu Gly 
385                 390                 395                 400 

Gly Lys Ala Thr Asn Lys Asn Ala Ala Tyr Tyr Gln Val Val Pro Val 
                405                 410                 415     

Thr Ala Asn Val Tyr Asp Ser Asp Gly Glu Lys Leu Ser Tyr Ile Ser 
            420                 425                 430         

Gln Gly Ser Val Val Trp Leu Asp Lys Asp Arg Lys Ser Asp Asp Lys 
        435                 440                 445             

Arg Leu Ala Ile Thr Ile Ser Gly Leu Ser Gly Tyr Met Lys Thr Glu 
    450                 455                 460                 

Asp Leu Gln Ala Leu Asp Ala Ser Lys Asp Phe Ile Pro Tyr Tyr Glu 
465                 470                 475                 480 

Ser Asp Gly His Arg Phe Tyr His Tyr Val Ala Gln Asn Ala Ser Ile 
                485                 490                 495     

Pro Val Ala Ser His Leu Ser Asp Met Glu Val Gly Lys Lys Tyr Tyr 
            500                 505                 510         

Ser Ala Asp Gly Leu His Phe Asp Gly Phe Lys Leu Glu Asn Pro Phe 
        515                 520                 525             

Leu Phe Lys Asp Leu Thr Glu Ala Thr Asn Tyr Ser Ala Glu Glu Leu 
    530                 535                 540                 

Asp Lys Val Phe Ser Leu Leu Asn Ile Asn Asn Ser Leu Leu Glu Asn 
545                 550                 555                 560 

Lys Gly Ala Thr Phe Lys Glu Ala Glu Glu His Tyr His Ile Asn Ala 
                565                 570                 575     

Leu Tyr Leu Leu Ala His Ser Ala Leu Glu Ser Asn Trp Gly Arg Ser 
            580                 585                 590         

Lys Ile Ala Lys Asp Lys Asn Asn Phe Phe Gly Ile Thr Ala Tyr Asp 
        595                 600                 605             

Thr Thr Pro Tyr Leu Ser Ala Lys Thr Phe Asp Asp Val Asp Lys Gly 
    610                 615                 620                 

Ile Leu Gly Ala Thr Lys Trp Ile Lys Glu Asn Tyr Ile Asp Arg Gly 
625                 630                 635                 640 

Arg Thr Phe Leu Gly Asn Lys Ala Ser Gly Met Asn Val Glu Tyr Ala 
                645                 650                 655     

Ser Asp Pro Tyr Trp Gly Glu Lys Ile Ala Ser Val Met Met Lys Ile 
            660                 665                 670         

Asn Glu Lys Leu Gly Gly Lys Asp 
        675                 680 

<210>   49
<211>   469
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Fragment of SEQ ID NO: 31, which omits the natural leader peptide sequence

<400>   49
Ala Asn Glu Thr Glu Val Ala Lys Thr Ser Gln Asp Thr Thr Thr Ala 
1               5                   10                  15      

Ser Ser Ser Ser Glu Gln Asn Gln Ser Ser Asn Lys Thr Gln Thr Ser 
            20                  25                  30          

Ala Glu Val Gln Thr Asn Ala Ala Ala Tyr Trp Asp Gly Asp Tyr Tyr 
        35                  40                  45              

Val Lys Asp Asp Gly Ser Lys Ala Gln Ser Glu Trp Ile Phe Asp Asn 
    50                  55                  60                  

Tyr Tyr Lys Ala Trp Phe Tyr Ile Asn Ser Asp Gly Arg Tyr Ser Gln 
65                  70                  75                  80  

Asn Glu Trp His Gly Asn Tyr Tyr Leu Lys Ser Gly Gly Tyr Met Ala 
                85                  90                  95      

Gln Asn Glu Trp Ile Tyr Asp Ser Asn Tyr Lys Ser Trp Phe Tyr Leu 
            100                 105                 110         

Lys Ser Asp Gly Ala Tyr Ala His Gln Glu Trp Gln Leu Ile Gly Asn 
        115                 120                 125             

Lys Trp Tyr Tyr Phe Lys Lys Trp Gly Tyr Met Ala Lys Ser Gln Trp 
    130                 135                 140                 

Gln Gly Ser Tyr Phe Leu Asn Gly Gln Gly Ala Met Ile Gln Asn Glu 
145                 150                 155                 160 

Trp Leu Tyr Asp Pro Ala Tyr Ser Ala Tyr Phe Tyr Leu Lys Ser Asp 
                165                 170                 175     

Gly Thr Tyr Ala Asn Gln Glu Trp Gln Lys Val Gly Gly Lys Trp Tyr 
            180                 185                 190         

Tyr Phe Lys Lys Trp Gly Tyr Met Ala Arg Asn Glu Trp Gln Gly Asn 
        195                 200                 205             

Tyr Tyr Leu Thr Gly Ser Gly Ala Met Ala Thr Asp Glu Val Ile Met 
    210                 215                 220                 

Asp Gly Ala Arg Tyr Ile Phe Ala Ala Ser Gly Glu Leu Lys Glu Lys 
225                 230                 235                 240 

Lys Asp Leu Asn Val Gly Trp Val His Arg Asp Gly Lys Arg Tyr Phe 
                245                 250                 255     

Phe Asn Asn Arg Glu Glu Gln Val Gly Thr Glu His Ala Lys Lys Ile 
            260                 265                 270         

Ile Asp Ile Ser Glu His Asn Gly Arg Ile Asn Asp Trp Lys Lys Val 
        275                 280                 285             

Ile Asp Glu Asn Lys Val Asp Gly Val Ile Val Arg Leu Gly Tyr Ser 
    290                 295                 300                 

Gly Lys Glu Asp Lys Glu Leu Ala His Asn Ile Lys Glu Leu Asn Arg 
305                 310                 315                 320 

Leu Gly Ile Pro Tyr Gly Val Tyr Leu Tyr Thr Tyr Ala Glu Asn Glu 
                325                 330                 335     

Thr Asp Ala Glu Asn Asp Ala Lys Gln Thr Ile Glu Leu Ile Lys Lys 
            340                 345                 350         

Tyr Asn Met Asn Leu Ser Tyr Pro Ile Tyr Tyr Asp Val Glu Asn Trp 
        355                 360                 365             

Glu Tyr Val Asn Lys Ser Lys Arg Ala Pro Ser Asp Thr Asp Thr Trp 
    370                 375                 380                 

Val Lys Ile Ile Asn Lys Tyr Met Asp Thr Met Lys Gln Ala Gly Tyr 
385                 390                 395                 400 

Gln Asn Val Tyr Val Tyr Ser Tyr Arg Ser Leu Leu Gln Thr Arg Leu 
                405                 410                 415     

Lys His Pro Asp Ile Leu Lys His Val Asn Trp Val Ala Ala Tyr Thr 
            420                 425                 430         

Asn Ala Leu Glu Trp Glu Asn Pro Tyr Tyr Ser Gly Glu Lys Gly Trp 
        435                 440                 445             

Gln Tyr Thr Ser Ser Glu Tyr Met Lys Gly Ile Gln Gly Arg Val Asp 
    450                 455                 460                 

Val Ser Val Trp Tyr 
465                 

<210>   50
<211>   471
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   SEQ ID NO: 32, including Pro325 to Leu mutation

<400>   50
Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      

Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          

Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              

Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  

Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  

Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      

Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         

Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             

Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 

Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 

Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     

Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         

Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             

Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 

Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 

Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     

Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         

Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             

Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 

Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 

Thr Ala Asp His Leu Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     

Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         

Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             

Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 

Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 

Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     

Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         

Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             

Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 

Glu Asp Lys Val Glu Asn Asp 
465                 470     

<210>   51
<211>   471
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   SEQ ID NO: 32, which includes Pro325 to Leu and Trp433 to Phe mutations

<400>   51
Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      

Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          

Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              

Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  

Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  

Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      

Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         

Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             

Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 

Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 

Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     

Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         

Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             

Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 

Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 

Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     

Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         

Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             

Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 

Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 

Thr Ala Asp His Leu Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     

Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         

Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             

Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 

Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 

Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     

Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         

Phe Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             

Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 

Glu Asp Lys Val Glu Asn Asp 
465                 470     

<210>   52
<211>   464
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   SEQ ID NO: 32 with Pro325 to Leu mutation with a 7-mer truncation

<400>   52
Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      

Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          

Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              

Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  

Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  

Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      

Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         

Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             

Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 

Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 

Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     

Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         

Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             

Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 

Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 

Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     

Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         

Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             

Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 

Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 

Thr Ala Asp His Leu Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     

Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         

Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             

Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 

Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 

Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     

Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         

Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             

Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


<210>   53
<211>   366
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   SEQ ID NO: 33 , which omits the natural leader peptide sequence

<400>   53
Ala Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp Asn Lys Ile Ser 
1               5                   10                  15      

Asn Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln Val Asp Gln Ile 
            20                  25                  30          

Gln Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser Asn Leu Gln Ala 
        35                  40                  45              

Glu Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu Glu Gly Glu Ile 
    50                  55                  60                  

Thr Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln Ser Leu Glu Lys 
65                  70                  75                  80  

Gln Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr Ser Tyr Ile Asn 
                85                  90                  95      

Thr Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile Ser Arg Val Ala 
            100                 105                 110         

Ala Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met Leu Glu Gln Gln 
        115                 120                 125             

Lys Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val Ala Asn Asn Asp 
    130                 135                 140                 

Ala Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu Ala Asp Asp Ala 
145                 150                 155                 160 

Gln Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala Ala Glu Leu Ser 
                165                 170                 175     

Leu Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys Ala Ser Leu Leu 
            180                 185                 190         

Glu Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala Ala Ala Val Ala 
        195                 200                 205             

Glu Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln Gln Ser Val Leu 
    210                 215                 220                 

Ala Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln Ala Val Ser Glu 
225                 230                 235                 240 

Ser Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro Thr Tyr Ser Thr 
                245                 250                 255     

Asn Ala Ser Ser Tyr Pro Ile Gly Glu Cys Thr Trp Gly Val Lys Thr 
            260                 265                 270         

Leu Ala Pro Trp Ala Gly Asp Tyr Trp Gly Asn Gly Ala Gln Trp Ala 
        275                 280                 285             

Thr Ser Ala Ala Ala Ala Gly Phe Arg Thr Gly Ser Thr Pro Gln Val 
    290                 295                 300                 

Gly Ala Ile Ala Cys Trp Asn Asp Gly Gly Tyr Gly His Val Ala Val 
305                 310                 315                 320 

Val Thr Ala Val Glu Ser Thr Thr Arg Ile Gln Val Ser Glu Ser Asn 
                325                 330                 335     

Tyr Ala Gly Asn Arg Thr Ile Gly Asn His Arg Gly Trp Phe Asn Pro 
            340                 345                 350         

Thr Thr Thr Ser Glu Gly Phe Val Thr Tyr Ile Tyr Ala Asp 
        355                 360                 365     

<210>   54
<211>   195
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   variant form of spr0096, with an insert near its C-terminus relative to SEQ ID NO: 34

<400>   54
Met Lys Ser Ile Thr Lys Lys Ile Lys Ala Thr Leu Ala Gly Val Ala 
1               5                   10                  15      

Ala Leu Phe Ala Val Phe Ala Pro Ser Phe Val Ser Ala Gln Glu Ser 
            20                  25                  30          

Ser Thr Tyr Thr Val Lys Glu Gly Asp Thr Leu Ser Glu Ile Ala Glu 
        35                  40                  45              

Thr His Asn Thr Thr Val Glu Lys Leu Ala Glu Asn Asn His Ile Asp 
    50                  55                  60                  

Asn Ile His Leu Ile Tyr Val Asp Gln Glu Leu Val Ile Asp Gly Pro 
65                  70                  75                  80  

Val Ala Pro Val Ala Thr Pro Ala Pro Ala Thr Tyr Ala Ala Pro Ala 
                85                  90                  95      

Ala Gln Asp Glu Thr Val Ser Ala Pro Val Ala Glu Thr Pro Val Val 
            100                 105                 110         

Ser Glu Thr Val Val Ser Thr Val Ser Gly Ser Glu Ala Glu Ala Lys 
        115                 120                 125             

Glu Trp Ile Ala Gln Lys Glu Ser Gly Gly Ser Tyr Thr Ala Thr Asn 
    130                 135                 140                 

Gly Arg Tyr Ile Gly Arg Tyr Gln Leu Thr Asp Ser Tyr Leu Asn Gly 
145                 150                 155                 160 

Asp Tyr Ser Ala Glu Asn Gln Glu Arg Val Ala Asp Ala Tyr Val Ala 
                165                 170                 175     

Gly Arg Tyr Gly Ser Trp Thr Ala Ala Lys Asn Phe Trp Leu Asn Asn 
            180                 185                 190         

Gly Trp Tyr 
        195 

<210>   55
<211>   659
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   variant form of spr1707

<400>   55
Met Lys Lys Asn Arg Val Phe Ala Thr Ala Gly Leu Val Leu Leu Ala 
1               5                   10                  15      

Ala Gly Val Leu Ala Ala Cys Ser Ser Ser Lys Ser Ser Asp Ser Ser 
            20                  25                  30          

Ala Pro Lys Ala Tyr Gly Tyr Val Tyr Thr Ala Asp Pro Glu Thr Leu 
        35                  40                  45              

Asp Tyr Leu Ile Ser Ser Lys Asn Ser Thr Thr Val Val Thr Ser Asn 
    50                  55                  60                  

Gly Ile Asp Gly Leu Phe Thr Asn Asp Asn Tyr Gly Asn Leu Ala Pro 
65                  70                  75                  80  

Ala Val Ala Glu Asp Trp Glu Val Ser Lys Asp Gly Leu Thr Tyr Thr 
                85                  90                  95      

Tyr Lys Ile Arg Lys Gly Val Lys Trp Phe Thr Ser Asp Gly Glu Glu 
            100                 105                 110         

Tyr Ala Glu Val Thr Ala Lys Asp Phe Val Asn Gly Leu Lys His Ala 
        115                 120                 125             

Ala Asp Lys Lys Ser Glu Ala Met Tyr Leu Ala Glu Asn Ser Val Lys 
    130                 135                 140                 

Gly Leu Ala Asp Tyr Leu Ser Gly Thr Ser Thr Asp Phe Ser Thr Val 
145                 150                 155                 160 

Gly Val Lys Ala Val Asp Asp Tyr Thr Leu Gln Tyr Thr Leu Asn Gln 
                165                 170                 175     

Pro Glu Pro Phe Trp Asn Ser Lys Leu Thr Tyr Ser Ile Phe Trp Pro 
            180                 185                 190         

Leu Asn Glu Glu Phe Glu Thr Ser Lys Gly Ser Asp Phe Ala Lys Pro 
        195                 200                 205             

Thr Asp Pro Thr Ser Leu Leu Tyr Asn Gly Pro Phe Leu Leu Lys Gly 
    210                 215                 220                 

Leu Thr Ala Lys Ser Ser Val Glu Phe Val Lys Asn Glu Gln Tyr Trp 
225                 230                 235                 240 

Asp Lys Glu Asn Val His Leu Asp Thr Ile Asn Leu Ala Tyr Tyr Asp 
                245                 250                 255     

Gly Ser Asp Gln Glu Ser Leu Glu Arg Asn Phe Thr Ser Gly Ala Tyr 
            260                 265                 270         

Ser Tyr Ala Arg Leu Tyr Pro Thr Ser Ser Asn Tyr Ser Lys Val Ala 
        275                 280                 285             

Glu Glu Tyr Lys Asp Asn Ile Tyr Tyr Thr Gln Ser Gly Ser Gly Ile 
    290                 295                 300                 

Ala Gly Leu Gly Val Asn Ile Asp Arg Gln Ser Tyr Asn Tyr Thr Ser 
305                 310                 315                 320 

Lys Thr Thr Asp Ser Glu Lys Val Ala Thr Lys Lys Ala Leu Leu Asn 
                325                 330                 335     

Lys Asp Phe Arg Gln Ala Leu Asn Phe Ala Leu Asp Arg Ser Ala Tyr 
            340                 345                 350         

Ser Ala Gln Ile Asn Gly Lys Asp Gly Ala Ala Leu Ala Val Arg Asn 
        355                 360                 365             

Leu Phe Val Lys Pro Asp Phe Val Ser Ala Gly Glu Lys Thr Phe Gly 
    370                 375                 380                 

Asp Leu Val Ala Ala Gln Leu Pro Ala Tyr Gly Asp Glu Trp Lys Gly 
385                 390                 395                 400 

Val Asn Leu Ala Asp Gly Gln Asp Gly Leu Phe Asn Ala Asp Lys Ala 
                405                 410                 415     

Lys Ala Glu Phe Ala Lys Ala Lys Lys Ala Leu Glu Ala Asp Gly Val 
            420                 425                 430         

Gln Phe Pro Ile His Leu Asp Val Pro Val Asp Gln Ala Ser Lys Asn 
        435                 440                 445             

Tyr Ile Ser Arg Ile Gln Ser Phe Lys Gln Ser Val Glu Thr Val Leu 
    450                 455                 460                 

Gly Val Glu Asn Val Val Val Asp Ile Gln Gln Met Thr Ser Asp Glu 
465                 470                 475                 480 

Phe Leu Asn Ile Thr Tyr Tyr Ala Ala Asn Ala Ser Ser Glu Asp Trp 
                485                 490                 495     

Asp Val Ser Gly Gly Val Ser Trp Gly Pro Asp Tyr Gln Asp Pro Ser 
            500                 505                 510         

Thr Tyr Leu Asp Ile Leu Lys Thr Thr Ser Ser Glu Thr Thr Lys Thr 
        515                 520                 525             

Tyr Leu Gly Phe Asp Asn Pro Asn Ser Pro Ser Val Val Gln Val Gly 
    530                 535                 540                 

Leu Lys Glu Tyr Asp Lys Leu Val Asp Glu Ala Ala Arg Glu Thr Ser 
545                 550                 555                 560 

Asp Leu Asn Val Arg Tyr Glu Lys Tyr Ala Ala Ala Gln Ala Trp Leu 
                565                 570                 575     

Thr Asp Ser Ser Leu Phe Ile Pro Ala Met Ala Ser Ser Gly Ala Ala 
            580                 585                 590         

Pro Val Leu Ser Arg Ile Val Pro Phe Thr Gly Ala Ser Ala Gln Thr 
        595                 600                 605             

Gly Ser Lys Gly Ser Asp Val Tyr Phe Lys Tyr Leu Lys Ser Gln Asp 
    610                 615                 620                 

Lys Val Val Thr Lys Glu Glu Tyr Glu Lys Ala Arg Glu Lys Trp Leu 
625                 630                 635                 640 

Lys Glu Lys Ala Glu Ser Asn Glu Lys Ala Gln Lys Glu Leu Ala Ser 
                645                 650                 655     

His Val Lys 
            

<210>   56
<211>   294
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Fragment of SEQ ID NO: 37, which omits the natural leader peptide sequence

<400>   56
Ala Cys Ser Lys Gly Ser Glu Gly Ala Asp Leu Ile Ser Met Lys Gly 
1               5                   10                  15      

Asp Val Ile Thr Glu His Gln Phe Tyr Glu Gln Val Lys Asn Asn Pro 
            20                  25                  30          

Ser Ala Gln Gln Val Leu Leu Asn Met Thr Ile Gln Lys Val Phe Glu 
        35                  40                  45              

Lys Gln Tyr Gly Ser Glu Leu Asp Asp Lys Glu Val Asp Asp Thr Ile 
    50                  55                  60                  

Ala Glu Glu Lys Lys Gln Tyr Gly Glu Asn Tyr Gln Arg Val Leu Ser 
65                  70                  75                  80  

Gln Ala Gly Met Thr Leu Glu Thr Arg Lys Ala Gln Ile Arg Thr Ser 
                85                  90                  95      

Lys Leu Val Glu Leu Ala Val Lys Lys Val Ala Glu Ala Glu Leu Thr 
            100                 105                 110         

Asp Glu Ala Tyr Lys Lys Ala Phe Asp Glu Tyr Thr Pro Asp Val Thr 
        115                 120                 125             

Ala Gln Ile Ile Arg Leu Asn Asn Glu Asp Lys Ala Lys Glu Val Leu 
    130                 135                 140                 

Glu Lys Ala Lys Ala Glu Gly Ala Asp Phe Ala Gln Leu Ala Lys Asp 
145                 150                 155                 160 

Asn Ser Thr Asp Glu Lys Thr Lys Glu Asn Gly Gly Glu Ile Thr Phe 
                165                 170                 175     

Asp Ser Ala Ser Thr Glu Val Pro Glu Gln Val Lys Lys Ala Ala Phe 
            180                 185                 190         

Ala Leu Asp Val Asp Gly Val Ser Asp Val Ile Thr Ala Thr Gly Thr 
        195                 200                 205             

Gln Ala Tyr Ser Ser Gln Tyr Tyr Ile Val Lys Leu Thr Lys Lys Thr 
    210                 215                 220                 

Glu Lys Ser Ser Asn Ile Asp Asp Tyr Lys Glu Lys Leu Lys Thr Val 
225                 230                 235                 240 

Ile Leu Thr Gln Lys Gln Asn Asp Ser Thr Phe Val Gln Ser Ile Ile 
                245                 250                 255     

Gly Lys Glu Leu Gln Ala Ala Asn Ile Lys Val Lys Asp Gln Ala Phe 
            260                 265                 270         

Gln Asn Ile Phe Thr Gln Tyr Ile Gly Gly Gly Asp Ser Ser Ser Ser 
        275                 280                 285             

Ser Ser Thr Ser Asn Glu 
    290                 

<210>   57
<211>   701
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr1995

<400>   57
Met Phe Ala Ser Lys Ser Glu Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Phe Ser Ile Gly Val Ala Ser Val Ala Val Ala Ser Leu Val Met Gly 
            20                  25                  30          

Ser Val Val His Ala Thr Glu Asn Glu Gly Ser Thr Gln Ala Ala Thr 
        35                  40                  45              

Ser Ser Asn Met Ala Lys Thr Glu His Arg Lys Ala Ala Lys Gln Val 
    50                  55                  60                  

Val Asp Glu Tyr Ile Glu Lys Met Leu Arg Glu Ile Gln Leu Asp Arg 
65                  70                  75                  80  

Arg Lys His Thr Gln Asn Val Ala Leu Asn Ile Lys Leu Ser Ala Ile 
                85                  90                  95      

Lys Thr Lys Tyr Leu Arg Glu Leu Asn Val Leu Glu Glu Lys Ser Lys 
            100                 105                 110         

Asp Glu Leu Pro Ser Glu Ile Lys Ala Lys Leu Asp Ala Ala Phe Glu 
        115                 120                 125             

Lys Phe Lys Lys Asp Thr Leu Lys Pro Gly Glu Lys Val Ala Glu Ala 
    130                 135                 140                 

Lys Lys Lys Val Glu Glu Ala Lys Lys Lys Ala Glu Asp Gln Lys Glu 
145                 150                 155                 160 

Glu Asp Arg Arg Asn Tyr Pro Thr Asn Thr Tyr Lys Thr Leu Glu Leu 
                165                 170                 175     

Glu Ile Ala Glu Phe Asp Val Lys Val Lys Glu Ala Glu Leu Glu Leu 
            180                 185                 190         

Val Lys Glu Glu Ala Lys Glu Ser Arg Asn Glu Gly Thr Ile Lys Gln 
        195                 200                 205             

Ala Lys Glu Lys Val Glu Ser Lys Lys Ala Glu Ala Thr Arg Leu Glu 
    210                 215                 220                 

Asn Ile Lys Thr Asp Arg Lys Lys Ala Glu Glu Glu Ala Lys Arg Lys 
225                 230                 235                 240 

Ala Asp Ala Lys Leu Lys Glu Ala Asn Val Ala Thr Ser Asp Gln Gly 
                245                 250                 255     

Lys Pro Lys Gly Arg Ala Lys Arg Gly Val Pro Gly Glu Leu Ala Thr 
            260                 265                 270         

Pro Asp Lys Lys Glu Asn Asp Ala Lys Ser Ser Asp Ser Ser Val Gly 
        275                 280                 285             

Glu Glu Thr Leu Pro Ser Ser Ser Leu Lys Ser Gly Lys Lys Val Ala 
    290                 295                 300                 

Glu Ala Glu Lys Lys Val Glu Glu Ala Glu Lys Lys Ala Lys Asp Gln 
305                 310                 315                 320 

Lys Glu Glu Asp Arg Arg Asn Tyr Pro Thr Asn Thr Tyr Lys Thr Leu 
                325                 330                 335     

Asp Leu Glu Ile Ala Glu Ser Asp Val Lys Val Lys Glu Ala Glu Leu 
            340                 345                 350         

Glu Leu Val Lys Glu Glu Ala Lys Glu Pro Arg Asp Glu Glu Lys Ile 
        355                 360                 365             

Lys Gln Ala Lys Ala Lys Val Glu Ser Lys Lys Ala Glu Ala Thr Arg 
    370                 375                 380                 

Leu Glu Asn Ile Lys Thr Asp Arg Lys Lys Ala Glu Glu Glu Ala Lys 
385                 390                 395                 400 

Arg Lys Ala Ala Glu Glu Asp Lys Val Lys Glu Lys Pro Ala Glu Gln 
                405                 410                 415     

Pro Gln Pro Ala Pro Ala Thr Gln Pro Glu Lys Pro Ala Pro Lys Pro 
            420                 425                 430         

Glu Lys Pro Ala Glu Gln Pro Lys Ala Glu Lys Thr Asp Asp Gln Gln 
        435                 440                 445             

Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg Leu 
    450                 455                 460                 

Thr Gln Gln Gln Pro Pro Lys Thr Glu Lys Pro Ala Gln Pro Ser Thr 
465                 470                 475                 480 

Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn 
                485                 490                 495     

Thr Asp Gly Ser Met Ala Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp 
            500                 505                 510         

Tyr Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Asn 
        515                 520                 525             

Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ser Met Ala Thr Gly 
    530                 535                 540                 

Trp Leu Gln Asn Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala 
545                 550                 555                 560 

Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn 
                565                 570                 575     

Ser Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp 
            580                 585                 590         

Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly Trp Leu Gln Asn 
        595                 600                 605             

Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly 
    610                 615                 620                 

Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Asp 
625                 630                 635                 640 

Met Ala Thr Gly Trp Val Lys Asp Gly Asp Thr Trp Tyr Tyr Leu Glu 
                645                 650                 655     

Ala Ser Gly Ala Met Lys Ala Ser Gln Trp Phe Lys Val Ser Asp Lys 
            660                 665                 670         

Trp Tyr Tyr Val Asn Gly Ser Gly Ala Leu Ala Val Asn Thr Thr Val 
        675                 680                 685             

Asp Gly Tyr Gly Val Asn Ala Asn Gly Glu Trp Val Asn 
    690                 695                 700     

<210>   58
<211>   196
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length ClpP

<400>   58
Met Ile Pro Val Val Ile Glu Gln Thr Ser Arg Gly Glu Arg Ser Tyr 
1               5                   10                  15      

Asp Ile Tyr Ser Arg Leu Leu Lys Asp Arg Ile Ile Met Leu Thr Gly 
            20                  25                  30          

Pro Val Glu Asp Asn Met Ala Asn Ser Val Ile Ala Gln Leu Leu Phe 
        35                  40                  45              

Leu Asp Ala Gln Asp Ser Thr Lys Asp Ile Tyr Leu Tyr Val Asn Thr 
    50                  55                  60                  

Pro Gly Gly Ser Val Ser Ala Gly Leu Ala Ile Val Asp Thr Met Asn 
65                  70                  75                  80  

Phe Ile Lys Ala Asp Val Gln Thr Ile Val Met Gly Met Ala Ala Ser 
                85                  90                  95      

Met Gly Thr Val Ile Ala Ser Ser Gly Ala Lys Gly Lys Arg Phe Met 
            100                 105                 110         

Leu Pro Asn Ala Glu Tyr Met Ile His Gln Pro Met Gly Gly Thr Gly 
        115                 120                 125             

Gly Gly Thr Gln Gln Thr Asp Met Ala Ile Ala Ala Glu His Leu Leu 
    130                 135                 140                 

Lys Thr Arg Asn Thr Leu Glu Lys Ile Leu Ala Glu Asn Ser Gly Gln 
145                 150                 155                 160 

Ser Met Glu Lys Val His Ala Asp Ala Glu Arg Asp Asn Trp Met Ser 
                165                 170                 175     

Ala Gln Glu Thr Leu Glu Tyr Gly Phe Ile Asp Glu Ile Met Ala Asn 
            180                 185                 190         

Asn Ser Leu Asn 
        195     

<210>   59
<211>   318
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length LytA

<400>   59
Met Glu Ile Asn Val Ser Lys Leu Arg Thr Asp Leu Pro Gln Val Gly 
1               5                   10                  15      

Val Gln Pro Tyr Arg Gln Val His Ala His Ser Thr Gly Asn Pro His 
            20                  25                  30          

Ser Thr Val Gln Asn Glu Ala Asp Tyr His Trp Arg Lys Asp Pro Glu 
        35                  40                  45              

Leu Gly Phe Phe Ser His Ile Val Gly Asn Gly Cys Ile Met Gln Val 
    50                  55                  60                  

Gly Pro Val Asp Asn Gly Ala Trp Asp Val Gly Gly Gly Trp Asn Ala 
65                  70                  75                  80  

Glu Thr Tyr Ala Ala Val Glu Leu Ile Glu Ser His Ser Thr Lys Glu 
                85                  90                  95      

Glu Phe Met Thr Asp Tyr Arg Leu Tyr Ile Glu Leu Leu Arg Asn Leu 
            100                 105                 110         

Ala Asp Glu Ala Gly Leu Pro Lys Thr Leu Asp Thr Gly Ser Leu Ala 
        115                 120                 125             

Gly Ile Lys Thr His Glu Tyr Cys Thr Asn Asn Gln Pro Asn Asn His 
    130                 135                 140                 

Ser Asp His Val Asp Pro Tyr Pro Tyr Leu Ala Lys Trp Gly Ile Ser 
145                 150                 155                 160 

Arg Glu Gln Phe Lys His Asp Ile Glu Asn Gly Leu Thr Ile Glu Thr 
                165                 170                 175     

Gly Trp Gln Lys Asn Asp Thr Gly Tyr Trp Tyr Val His Ser Asp Gly 
            180                 185                 190         

Ser Tyr Pro Lys Asp Lys Phe Glu Lys Ile Asn Gly Thr Trp Tyr Tyr 
        195                 200                 205             

Phe Asp Ser Ser Gly Tyr Met Leu Ala Asp Arg Trp Arg Lys His Thr 
    210                 215                 220                 

Asp Gly Asn Trp Tyr Trp Phe Asp Asn Ser Gly Glu Met Ala Thr Gly 
225                 230                 235                 240 

Trp Lys Lys Ile Ala Asp Lys Trp Tyr Tyr Phe Asn Glu Glu Gly Ala 
                245                 250                 255     

Met Lys Thr Gly Trp Val Lys Tyr Lys Asp Thr Trp Tyr Tyr Leu Asp 
            260                 265                 270         

Ala Lys Glu Gly Ala Met Val Ser Asn Ala Phe Ile Gln Ser Ala Asp 
        275                 280                 285             

Gly Thr Gly Trp Tyr Tyr Leu Lys Pro Asp Gly Thr Leu Ala Asp Arg 
    290                 295                 300                 

Pro Glu Phe Thr Val Glu Pro Asp Gly Leu Ile Thr Val Lys 
305                 310                 315             

<210>   60
<211>   828
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PhtA precursor

<400>   60
Met Gln Leu Glu Ile Ser Asn Arg Lys Arg Val Ser Met Lys Ile Asn 
1               5                   10                  15      

Lys Lys Tyr Leu Val Gly Ser Ala Ala Ala Leu Ile Leu Ser Val Cys 
            20                  25                  30          

Ser Tyr Glu Leu Gly Leu Tyr Gln Ala Arg Thr Val Lys Glu Asn Asn 
        35                  40                  45              

Arg Val Ser Tyr Ile Asp Gly Lys Gln Ala Thr Gln Lys Thr Glu Asn 
    50                  55                  60                  

Leu Thr Pro Asp Glu Val Ser Lys Arg Glu Gly Ile Asn Ala Glu Gln 
65                  70                  75                  80  

Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val Thr Ser His Gly Asp 
                85                  90                  95      

His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr Asp Ala Ile Phe Ser 
            100                 105                 110         

Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Lys Leu Lys Asp Glu Asp 
        115                 120                 125             

Ile Val Asn Glu Val Lys Gly Gly Tyr Val Ile Lys Val Asp Gly Lys 
    130                 135                 140                 

Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala Asp Asn Val Arg Thr 
145                 150                 155                 160 

Lys Glu Glu Ile Asn Arg Gln Lys Gln Glu His Ser Gln His Arg Glu 
                165                 170                 175     

Gly Gly Thr Pro Arg Asn Asp Gly Ala Val Ala Leu Ala Arg Ser Gln 
            180                 185                 190         

Gly Arg Tyr Thr Thr Asp Asp Gly Tyr Ile Phe Asn Ala Ser Asp Ile 
        195                 200                 205             

Ile Glu Asp Thr Gly Asp Ala Tyr Ile Val Pro His Gly Asp His Tyr 
    210                 215                 220                 

His Tyr Ile Pro Lys Asn Glu Leu Ser Ala Ser Glu Leu Ala Ala Ala 
225                 230                 235                 240 

Glu Ala Phe Leu Ser Gly Arg Gly Asn Leu Ser Asn Ser Arg Thr Tyr 
                245                 250                 255     

Arg Arg Gln Asn Ser Asp Asn Thr Ser Arg Thr Asn Trp Val Pro Ser 
            260                 265                 270         

Val Ser Asn Pro Gly Thr Thr Asn Thr Asn Thr Ser Asn Asn Ser Asn 
        275                 280                 285             

Thr Asn Ser Gln Ala Ser Gln Ser Asn Asp Ile Asp Ser Leu Leu Lys 
    290                 295                 300                 

Gln Leu Tyr Lys Leu Pro Leu Ser Gln Arg His Val Glu Ser Asp Gly 
305                 310                 315                 320 

Leu Val Phe Asp Pro Ala Gln Ile Thr Ser Arg Thr Ala Arg Gly Val 
                325                 330                 335     

Ala Val Pro His Gly Asp His Tyr His Phe Ile Pro Tyr Ser Gln Met 
            340                 345                 350         

Ser Glu Leu Glu Glu Arg Ile Ala Arg Ile Ile Pro Leu Arg Tyr Arg 
        355                 360                 365             

Ser Asn His Trp Val Pro Asp Ser Arg Pro Glu Gln Pro Ser Pro Gln 
    370                 375                 380                 

Pro Thr Pro Glu Pro Ser Pro Gly Pro Gln Pro Ala Pro Asn Leu Lys 
385                 390                 395                 400 

Ile Asp Ser Asn Ser Ser Leu Val Ser Gln Leu Val Arg Lys Val Gly 
                405                 410                 415     

Glu Gly Tyr Val Phe Glu Glu Lys Gly Ile Ser Arg Tyr Val Phe Ala 
            420                 425                 430         

Lys Asp Leu Pro Ser Glu Thr Val Lys Asn Leu Glu Ser Lys Leu Ser 
        435                 440                 445             

Lys Gln Glu Ser Val Ser His Thr Leu Thr Ala Lys Lys Glu Asn Val 
    450                 455                 460                 

Ala Pro Arg Asp Gln Glu Phe Tyr Asp Lys Ala Tyr Asn Leu Leu Thr 
465                 470                 475                 480 

Glu Ala His Lys Ala Leu Phe Glu Asn Lys Gly Arg Asn Ser Asp Phe 
                485                 490                 495     

Gln Ala Leu Asp Lys Leu Leu Glu Arg Leu Asn Asp Glu Ser Thr Asn 
            500                 505                 510         

Lys Glu Lys Leu Val Asp Asp Leu Leu Ala Phe Leu Ala Pro Ile Thr 
        515                 520                 525             

His Pro Glu Arg Leu Gly Lys Pro Asn Ser Gln Ile Glu Tyr Thr Glu 
    530                 535                 540                 

Asp Glu Val Arg Ile Ala Gln Leu Ala Asp Lys Tyr Thr Thr Ser Asp 
545                 550                 555                 560 

Gly Tyr Ile Phe Asp Glu His Asp Ile Ile Ser Asp Glu Gly Asp Ala 
                565                 570                 575     

Tyr Val Thr Pro His Met Gly His Ser His Trp Ile Gly Lys Asp Ser 
            580                 585                 590         

Leu Ser Asp Lys Glu Lys Val Ala Ala Gln Ala Tyr Thr Lys Glu Lys 
        595                 600                 605             

Gly Ile Leu Pro Pro Ser Pro Asp Ala Asp Val Lys Ala Asn Pro Thr 
    610                 615                 620                 

Gly Asp Ser Ala Ala Ala Ile Tyr Asn Arg Val Lys Gly Glu Lys Arg 
625                 630                 635                 640 

Ile Pro Leu Val Arg Leu Pro Tyr Met Val Glu His Thr Val Glu Val 
                645                 650                 655     

Lys Asn Gly Asn Leu Ile Ile Pro His Lys Asp His Tyr His Asn Ile 
            660                 665                 670         

Lys Phe Ala Trp Phe Asp Asp His Thr Tyr Lys Ala Pro Asn Gly Tyr 
        675                 680                 685             

Thr Leu Glu Asp Leu Phe Ala Thr Ile Lys Tyr Tyr Val Glu His Pro 
    690                 695                 700                 

Asp Glu Arg Pro His Ser Asn Asp Gly Trp Gly Asn Ala Ser Glu His 
705                 710                 715                 720 

Val Leu Gly Lys Lys Asp His Ser Glu Asp Pro Asn Lys Asn Phe Lys 
                725                 730                 735     

Ala Asp Glu Glu Pro Val Glu Glu Thr Pro Ala Glu Pro Glu Val Pro 
            740                 745                 750         

Gln Val Glu Thr Glu Lys Val Glu Ala Gln Leu Lys Glu Ala Glu Val 
        755                 760                 765             

Leu Leu Ala Lys Val Thr Asp Ser Ser Leu Lys Ala Asn Ala Thr Glu 
    770                 775                 780                 

Thr Leu Ala Gly Leu Arg Asn Asn Leu Thr Leu Gln Ile Met Asp Asn 
785                 790                 795                 800 

Asn Ser Ile Met Ala Glu Ala Glu Lys Leu Leu Ala Leu Leu Lys Gly 
                805                 810                 815     

Ser Asn Pro Ser Ser Val Ser Lys Glu Lys Ile Asn 
            820                 825             

<210>   61
<211>   819
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PhtB precursor

<220>
<221>   misc_feature
<222>   (578) ... (578)
<223>   any amino acid residue; optionally lysine

<400>   61
Met Lys Ile Asn Lys Lys Tyr Leu Ala Gly Ser Val Ala Val Leu Ala 
1               5                   10                  15      

Leu Ser Val Cys Ser Tyr Glu Leu Gly Arg Tyr Gln Ala Gly Gln Asp 
            20                  25                  30          

Lys Lys Glu Ser Asn Arg Val Ala Tyr Ile Asp Gly Asp Gln Ala Gly 
        35                  40                  45              

Gln Lys Ala Glu Asn Leu Thr Pro Asp Glu Val Ser Lys Arg Glu Gly 
    50                  55                  60                  

Ile Asn Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val 
65                  70                  75                  80  

Thr Ser His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr 
                85                  90                  95      

Asp Ala Ile Ile Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Gln 
            100                 105                 110         

Leu Lys Asp Ser Asp Ile Val Asn Glu Ile Lys Gly Gly Tyr Val Ile 
        115                 120                 125             

Lys Val Asn Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala 
    130                 135                 140                 

Asp Asn Ile Arg Thr Lys Glu Glu Ile Lys Arg Gln Lys Gln Glu Arg 
145                 150                 155                 160 

Ser His Asn His Asn Ser Arg Ala Asp Asn Ala Val Ala Ala Ala Arg 
                165                 170                 175     

Ala Gln Gly Arg Tyr Thr Thr Asp Asp Gly Tyr Ile Phe Asn Ala Ser 
            180                 185                 190         

Asp Ile Ile Glu Asp Thr Gly Asp Ala Tyr Ile Val Pro His Gly Asp 
        195                 200                 205             

His Tyr His Tyr Ile Pro Lys Asn Glu Leu Ser Ala Ser Glu Leu Ala 
    210                 215                 220                 

Ala Ala Glu Ala Tyr Trp Asn Gly Lys Gln Gly Ser Arg Pro Ser Ser 
225                 230                 235                 240 

Ser Ser Ser Tyr Asn Ala Asn Pro Ala Gln Pro Arg Leu Ser Glu Asn 
                245                 250                 255     

His Asn Leu Thr Val Thr Pro Thr Tyr His Gln Asn Gln Gly Glu Asn 
            260                 265                 270         

Ile Ser Ser Leu Leu Arg Glu Leu Tyr Ala Lys Pro Leu Ser Glu Arg 
        275                 280                 285             

His Val Glu Ser Asp Gly Leu Ile Phe Asp Pro Ala Gln Ile Thr Ser 
    290                 295                 300                 

Arg Thr Ala Arg Gly Val Ala Val Pro His Gly Asn His Tyr His Phe 
305                 310                 315                 320 

Ile Pro Tyr Glu Gln Met Ser Glu Leu Glu Lys Arg Ile Ala Arg Ile 
                325                 330                 335     

Ile Pro Leu Arg Tyr Arg Ser Asn His Trp Val Pro Asp Ser Arg Pro 
            340                 345                 350         

Glu Glu Pro Ser Pro Gln Pro Thr Pro Glu Pro Ser Pro Ser Pro Gln 
        355                 360                 365             

Pro Ala Pro Ser Asn Pro Ile Asp Gly Lys Leu Val Lys Glu Ala Val 
    370                 375                 380                 

Arg Lys Val Gly Asp Gly Tyr Val Phe Glu Glu Asn Gly Val Ser Arg 
385                 390                 395                 400 

Tyr Ile Pro Ala Lys Asp Leu Ser Ala Glu Thr Ala Ala Gly Ile Asp 
                405                 410                 415     

Ser Lys Leu Ala Lys Gln Glu Ser Leu Ser His Lys Leu Gly Thr Lys 
            420                 425                 430         

Lys Thr Asp Leu Pro Ser Ser Asp Arg Glu Phe Tyr Asn Lys Ala Tyr 
        435                 440                 445             

Asp Leu Leu Ala Arg Ile His Gln Asp Leu Leu Asp Asn Lys Gly Arg 
    450                 455                 460                 

Gln Val Asp Phe Glu Ala Leu Asp Asn Leu Leu Glu Arg Leu Lys Asp 
465                 470                 475                 480 

Val Ser Ser Asp Lys Val Lys Leu Val Glu Asp Ile Leu Ala Phe Leu 
                485                 490                 495     

Ala Pro Ile Arg His Pro Glu Arg Leu Gly Lys Pro Asn Ala Gln Ile 
            500                 505                 510         

Thr Tyr Thr Asp Asp Glu Ile Gln Val Ala Lys Leu Ala Gly Lys Tyr 
        515                 520                 525             

Thr Ala Glu Asp Gly Tyr Ile Phe Asp Pro Arg Asp Ile Thr Ser Asp 
    530                 535                 540                 

Glu Gly Asp Ala Tyr Val Thr Pro His Met Thr His Ser His Trp Ile 
545                 550                 555                 560 

Lys Lys Asp Ser Leu Ser Glu Ala Glu Arg Ala Ala Ala Gln Ala Tyr 
                565                 570                 575     

Ala Xaa Glu Lys Gly Leu Thr Pro Pro Ser Thr Asp His Gln Asp Ser 
            580                 585                 590         

Gly Asn Thr Glu Ala Lys Gly Ala Glu Ala Ile Tyr Asn Arg Val Lys 
        595                 600                 605             

Ala Ala Lys Lys Val Pro Leu Asp Arg Met Pro Tyr Asn Leu Gln Tyr 
    610                 615                 620                 

Thr Val Glu Val Lys Asn Gly Ser Leu Ile Ile Pro His Tyr Asp His 
625                 630                 635                 640 

Tyr His Asn Ile Lys Phe Glu Trp Phe Asp Glu Gly Leu Tyr Glu Ala 
                645                 650                 655     

Pro Lys Gly Tyr Thr Leu Glu Asp Leu Leu Ala Thr Val Lys Tyr Tyr 
            660                 665                 670         

Val Glu His Pro Asn Glu Arg Pro His Ser Asp Asn Gly Phe Gly Asn 
        675                 680                 685             

Ala Ser Asp His Val Gln Arg Asn Lys Asn Gly Gln Ala Asp Thr Asn 
    690                 695                 700                 

Gln Thr Glu Lys Pro Ser Glu Glu Lys Pro Gln Thr Glu Lys Pro Glu 
705                 710                 715                 720 

Glu Glu Thr Pro Arg Glu Glu Lys Pro Gln Ser Glu Lys Pro Glu Ser 
                725                 730                 735     

Pro Lys Pro Thr Glu Glu Pro Glu Glu Ser Pro Glu Glu Ser Glu Glu 
            740                 745                 750         

Pro Gln Val Glu Thr Glu Lys Val Glu Glu Lys Leu Arg Glu Ala Glu 
        755                 760                 765             

Asp Leu Leu Gly Lys Ile Gln Asp Pro Ile Ile Lys Ser Asn Ala Lys 
    770                 775                 780                 

Glu Thr Leu Thr Gly Leu Lys Asn Asn Leu Leu Phe Gly Thr Gln Asp 
785                 790                 795                 800 

Asn Asn Thr Ile Met Ala Glu Ala Glu Lys Leu Leu Ala Leu Leu Lys 
                805                 810                 815     

Glu Ser Lys 
            

<210>   62
<211>   853
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PhtD precursor

<400>   62
Met Lys Ile Asn Lys Lys Tyr Leu Ala Gly Ser Val Ala Val Leu Ala 
1               5                   10                  15      

Leu Ser Val Cys Ser Tyr Glu Leu Gly Arg His Gln Ala Gly Gln Val 
            20                  25                  30          

Lys Lys Glu Ser Asn Arg Val Ser Tyr Ile Asp Gly Asp Gln Ala Gly 
        35                  40                  45              

Gln Lys Ala Glu Asn Leu Thr Pro Asp Glu Val Ser Lys Arg Glu Gly 
    50                  55                  60                  

Ile Asn Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val 
65                  70                  75                  80  

Thr Ser His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr 
                85                  90                  95      

Asp Ala Ile Ile Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Gln 
            100                 105                 110         

Leu Lys Asp Ser Asp Ile Val Asn Glu Ile Lys Gly Gly Tyr Val Ile 
        115                 120                 125             

Lys Val Asp Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala 
    130                 135                 140                 

Asp Asn Ile Arg Thr Lys Glu Glu Ile Lys Arg Gln Lys Gln Glu Arg 
145                 150                 155                 160 

Ser His Asn His Asn Ser Arg Ala Asp Asn Ala Val Ala Ala Ala Arg 
                165                 170                 175     

Ala Gln Gly Arg Tyr Thr Thr Asp Asp Gly Tyr Ile Phe Asn Ala Ser 
            180                 185                 190         

Asp Ile Ile Glu Asp Thr Gly Asp Ala Tyr Ile Val Pro His Gly Asp 
        195                 200                 205             

His Tyr His Tyr Ile Pro Lys Ser Asp Leu Ser Ala Ser Glu Leu Ala 
    210                 215                 220                 

Ala Ala Gln Ala Tyr Trp Asn Gly Lys Gln Gly Ser Arg Pro Ser Ser 
225                 230                 235                 240 

Ser Ser Ser His Asn Ala Asn Pro Ala Gln Pro Arg Leu Ser Glu Asn 
                245                 250                 255     

His Asn Leu Thr Val Thr Pro Thr Tyr His Gln Asn Gln Gly Glu Asn 
            260                 265                 270         

Ile Ser Ser Leu Leu Arg Glu Leu Tyr Ala Lys Pro Leu Ser Glu Arg 
        275                 280                 285             

His Val Glu Ser Asp Gly Leu Ile Phe Asp Pro Ala Gln Ile Thr Ser 
    290                 295                 300                 

Arg Thr Ala Asn Gly Val Ala Val Pro His Gly Asp His Tyr His Phe 
305                 310                 315                 320 

Ile Pro Tyr Ser Gln Leu Ser Pro Leu Glu Glu Lys Leu Ala Arg Ile 
                325                 330                 335     

Ile Pro Leu Arg Tyr Arg Ser Asn His Trp Val Pro Asp Ser Arg Pro 
            340                 345                 350         

Glu Gln Pro Ser Pro Gln Ser Thr Pro Glu Pro Ser Pro Ser Pro Gln 
        355                 360                 365             

Pro Ala Pro Asn Pro Gln Pro Ala Pro Ser Asn Pro Ile Asp Glu Lys 
    370                 375                 380                 

Leu Val Lys Glu Ala Val Arg Lys Val Gly Asp Gly Tyr Val Phe Glu 
385                 390                 395                 400 

Glu Asn Gly Val Pro Arg Tyr Ile Pro Ala Lys Asp Leu Ser Ala Glu 
                405                 410                 415     

Thr Ala Ala Gly Ile Asp Ser Lys Leu Ala Lys Gln Glu Ser Leu Ser 
            420                 425                 430         

His Lys Leu Gly Ala Lys Lys Thr Asp Leu Pro Ser Ser Asp Arg Glu 
        435                 440                 445             

Phe Tyr Asn Lys Ala Tyr Asp Leu Leu Ala Arg Ile His Gln Asp Leu 
    450                 455                 460                 

Leu Asp Asn Lys Gly Arg Gln Val Asp Phe Glu Ala Leu Asp Asn Leu 
465                 470                 475                 480 

Leu Glu Arg Leu Lys Asp Val Ser Ser Asp Lys Val Lys Leu Val Asp 
                485                 490                 495     

Asp Ile Leu Ala Phe Leu Ala Pro Ile Arg His Pro Glu Arg Leu Gly 
            500                 505                 510         

Lys Pro Asn Ala Gln Ile Thr Tyr Thr Asp Asp Glu Ile Gln Val Ala 
        515                 520                 525             

Lys Leu Ala Gly Lys Tyr Thr Thr Glu Asp Gly Tyr Ile Phe Asp Pro 
    530                 535                 540                 

Arg Asp Ile Thr Ser Asp Glu Gly Asp Ala Tyr Val Thr Pro His Met 
545                 550                 555                 560 

Thr His Ser His Trp Ile Lys Lys Asp Ser Leu Ser Glu Ala Glu Arg 
                565                 570                 575     

Ala Ala Ala Gln Ala Tyr Ala Lys Glu Lys Gly Leu Thr Pro Pro Ser 
            580                 585                 590         

Thr Asp His Gln Asp Ser Gly Asn Thr Glu Ala Lys Gly Ala Glu Ala 
        595                 600                 605             

Ile Tyr Asn Arg Val Lys Ala Ala Lys Lys Val Pro Leu Asp Arg Met 
    610                 615                 620                 

Pro Tyr Asn Leu Gln Tyr Thr Val Glu Val Lys Asn Gly Ser Leu Ile 
625                 630                 635                 640 

Ile Pro His Tyr Asp His Tyr His Asn Ile Lys Phe Glu Trp Phe Asp 
                645                 650                 655     

Glu Gly Leu Tyr Glu Ala Pro Lys Gly Tyr Ser Leu Glu Asp Leu Leu 
            660                 665                 670         

Ala Thr Val Lys Tyr Tyr Val Glu His Pro Asn Glu Arg Pro His Ser 
        675                 680                 685             

Asp Asn Gly Phe Gly Asn Ala Ser Asp His Val Gln Arg Asn Lys Asn 
    690                 695                 700                 

Gly Gln Ala Asp Thr Asn Gln Thr Glu Lys Pro Asn Glu Glu Lys Pro 
705                 710                 715                 720 

Gln Thr Glu Lys Pro Glu Glu Asp Lys Glu His Asp Glu Val Ser Glu 
                725                 730                 735     

Pro Thr His Pro Glu Ser Asp Glu Lys Glu Asn His Val Gly Leu Asn 
            740                 745                 750         

Pro Ser Ala Asp Asn Leu Tyr Lys Pro Ser Thr Asp Thr Glu Glu Thr 
        755                 760                 765             

Glu Glu Glu Ala Glu Asp Thr Thr Asp Glu Ala Glu Ile Pro Gln Val 
    770                 775                 780                 

Glu His Ser Val Ile Asn Ala Lys Ile Ala Glu Ala Glu Ala Leu Leu 
785                 790                 795                 800 

Glu Lys Val Thr Asp Ser Ser Ile Arg Gln Asn Ala Val Glu Thr Leu 
                805                 810                 815     

Thr Gly Leu Lys Ser Ser Leu Leu Leu Gly Thr Lys Asp Asn Asn Thr 
            820                 825                 830         

Ile Ser Ala Glu Val Asp Ser Leu Leu Ala Leu Leu Lys Glu Ser Gln 
        835                 840                 845             

Pro Thr Pro Ile Gln 
    850             

<210>   63
<211>   1039
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PhtE precursor

<400>   63
Met Lys Phe Ser Lys Lys Tyr Ile Ala Ala Gly Ser Ala Val Ile Val 
1               5                   10                  15      

Ser Leu Ser Leu Cys Ala Tyr Ala Leu Asn Gln His Arg Ser Gln Glu 
            20                  25                  30          

Asn Lys Asp Asn Asn Arg Val Ser Tyr Val Asp Gly Ser Gln Ser Ser 
        35                  40                  45              

Gln Lys Ser Glu Asn Leu Thr Pro Asp Gln Val Ser Gln Lys Glu Gly 
    50                  55                  60                  

Ile Gln Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val 
65                  70                  75                  80  

Thr Ser His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr 
                85                  90                  95      

Asp Ala Leu Phe Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Gln 
            100                 105                 110         

Leu Lys Asp Ala Asp Ile Val Asn Glu Val Lys Gly Gly Tyr Ile Ile 
        115                 120                 125             

Lys Val Asp Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala 
    130                 135                 140                 

Asp Asn Val Arg Thr Lys Asp Glu Ile Asn Arg Gln Lys Gln Glu His 
145                 150                 155                 160 

Val Lys Asp Asn Glu Lys Val Asn Ser Asn Val Ala Val Ala Arg Ser 
                165                 170                 175     

Gln Gly Arg Tyr Thr Thr Asn Asp Gly Tyr Val Phe Asn Pro Ala Asp 
            180                 185                 190         

Ile Ile Glu Asp Thr Gly Asn Ala Tyr Ile Val Pro His Gly Gly His 
        195                 200                 205             

Tyr His Tyr Ile Pro Lys Ser Asp Leu Ser Ala Ser Glu Leu Ala Ala 
    210                 215                 220                 

Ala Lys Ala His Leu Ala Gly Lys Asn Met Gln Pro Ser Gln Leu Ser 
225                 230                 235                 240 

Tyr Ser Ser Thr Ala Ser Asp Asn Asn Thr Gln Ser Val Ala Lys Gly 
                245                 250                 255     

Ser Thr Ser Lys Pro Ala Asn Lys Ser Glu Asn Leu Gln Ser Leu Leu 
            260                 265                 270         

Lys Glu Leu Tyr Asp Ser Pro Ser Ala Gln Arg Tyr Ser Glu Ser Asp 
        275                 280                 285             

Gly Leu Val Phe Asp Pro Ala Lys Ile Ile Ser Arg Thr Pro Asn Gly 
    290                 295                 300                 

Val Ala Ile Pro His Gly Asp His Tyr His Phe Ile Pro Tyr Ser Lys 
305                 310                 315                 320 

Leu Ser Ala Leu Glu Glu Lys Ile Ala Arg Arg Val Pro Ile Ser Gly 
                325                 330                 335     

Thr Gly Ser Thr Val Ser Thr Asn Ala Lys Pro Asn Glu Val Val Ser 
            340                 345                 350         

Ser Leu Gly Ser Leu Ser Ser Asn Pro Ser Ser Leu Thr Thr Ser Lys 
        355                 360                 365             

Glu Leu Ser Ser Ala Ser Asp Gly Tyr Ile Phe Asn Pro Lys Asp Ile 
    370                 375                 380                 

Val Glu Glu Thr Ala Thr Ala Tyr Ile Val Arg His Gly Asp His Phe 
385                 390                 395                 400 

His Tyr Ile Pro Lys Ser Asn Gln Ile Gly Gln Pro Thr Leu Pro Asn 
                405                 410                 415     

Asn Ser Leu Ala Thr Pro Ser Pro Ser Leu Pro Ile Asn Pro Gly Ile 
            420                 425                 430         

Ser His Glu Lys His Glu Glu Asp Gly Tyr Gly Phe Asp Ala Asn Arg 
        435                 440                 445             

Ile Ile Ala Glu Asp Glu Ser Gly Phe Ile Met Ser His Gly Asn His 
    450                 455                 460                 

Asn His Tyr Phe Phe Lys Lys Asp Leu Thr Glu Glu Gln Ile Lys Ala 
465                 470                 475                 480 

Ala Gln Lys His Leu Glu Glu Val Lys Thr Ser His Asn Gly Leu Asp 
                485                 490                 495     

Ser Leu Ser Ser His Glu Gln Asp Tyr Pro Gly Asn Ala Lys Glu Met 
            500                 505                 510         

Lys Asp Leu Asp Lys Lys Ile Glu Glu Lys Ile Ala Gly Ile Met Lys 
        515                 520                 525             

Gln Tyr Gly Val Lys Arg Glu Ser Ile Val Val Asn Lys Glu Lys Asn 
    530                 535                 540                 

Ala Ile Ile Tyr Pro His Gly Asp His His His Ala Asp Pro Ile Asp 
545                 550                 555                 560 

Glu His Lys Pro Val Gly Ile Gly His Ser His Ser Asn Tyr Glu Leu 
                565                 570                 575     

Phe Lys Pro Glu Glu Gly Val Ala Lys Lys Glu Gly Asn Lys Val Tyr 
            580                 585                 590         

Thr Gly Glu Glu Leu Thr Asn Val Val Asn Leu Leu Lys Asn Ser Thr 
        595                 600                 605             

Phe Asn Asn Gln Asn Phe Thr Leu Ala Asn Gly Gln Lys Arg Val Ser 
    610                 615                 620                 

Phe Ser Phe Pro Pro Glu Leu Glu Lys Lys Leu Gly Ile Asn Met Leu 
625                 630                 635                 640 

Val Lys Leu Ile Thr Pro Asp Gly Lys Val Leu Glu Lys Val Ser Gly 
                645                 650                 655     

Lys Val Phe Gly Glu Gly Val Gly Asn Ile Ala Asn Phe Glu Leu Asp 
            660                 665                 670         

Gln Pro Tyr Leu Pro Gly Gln Thr Phe Lys Tyr Thr Ile Ala Ser Lys 
        675                 680                 685             

Asp Tyr Pro Glu Val Ser Tyr Asp Gly Thr Phe Thr Val Pro Thr Ser 
    690                 695                 700                 

Leu Ala Tyr Lys Met Ala Ser Gln Thr Ile Phe Tyr Pro Phe His Ala 
705                 710                 715                 720 

Gly Asp Thr Tyr Leu Arg Val Asn Pro Gln Phe Ala Val Pro Lys Gly 
                725                 730                 735     

Thr Asp Ala Leu Val Arg Val Phe Asp Glu Phe His Gly Asn Ala Tyr 
            740                 745                 750         

Leu Glu Asn Asn Tyr Lys Val Gly Glu Ile Lys Leu Pro Ile Pro Lys 
        755                 760                 765             

Leu Asn Gln Gly Thr Thr Arg Thr Ala Gly Asn Lys Ile Pro Val Thr 
    770                 775                 780                 

Phe Met Ala Asn Ala Tyr Leu Asp Asn Gln Ser Thr Tyr Ile Val Glu 
785                 790                 795                 800 

Val Pro Ile Leu Glu Lys Glu Asn Gln Thr Asp Lys Pro Ser Ile Leu 
                805                 810                 815     

Pro Gln Phe Lys Arg Asn Lys Ala Gln Glu Asn Ser Lys Leu Asp Glu 
            820                 825                 830         

Lys Val Glu Glu Pro Lys Thr Ser Glu Lys Val Glu Lys Glu Lys Leu 
        835                 840                 845             

Ser Glu Thr Gly Asn Ser Thr Ser Asn Ser Thr Leu Glu Glu Val Pro 
    850                 855                 860                 

Thr Val Asp Pro Val Gln Glu Lys Val Ala Lys Phe Ala Glu Ser Tyr 
865                 870                 875                 880 

Gly Met Lys Leu Glu Asn Val Leu Phe Asn Met Asp Gly Thr Ile Glu 
                885                 890                 895     

Leu Tyr Leu Pro Ser Gly Glu Val Ile Lys Lys Asn Met Ala Asp Phe 
            900                 905                 910         

Thr Gly Glu Ala Pro Gln Gly Asn Gly Glu Asn Lys Pro Ser Glu Asn 
        915                 920                 925             

Gly Lys Val Ser Thr Gly Thr Val Glu Asn Gln Pro Thr Glu Asn Lys 
    930                 935                 940                 

Pro Ala Asp Ser Leu Pro Glu Ala Pro Asn Glu Lys Pro Val Lys Pro 
945                 950                 955                 960 

Glu Asn Ser Thr Asp Asn Gly Met Leu Asn Pro Glu Gly Asn Val Gly 
                965                 970                 975     

Ser Asp Pro Met Leu Asp Pro Ala Leu Glu Glu Ala Pro Ala Val Asp 
            980                 985                 990         

Pro Val Gln Glu Lys Leu Glu Lys Phe Thr Ala Ser Tyr Gly Leu Gly 
        995                 1000                1005            

Leu Asp Ser Val Ile Phe Asn Met Asp Gly Thr Ile Glu Leu Arg Leu 
    1010                1015                1020                

Pro Ser Gly Glu Val Ile Lys Lys Asn Leu Ser Asp Leu Ile Ala 
1025                1030                1035                

<210>   64
<211>   1876
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length ZmpB

<400>   64
Met Phe Lys Lys Asp Arg Phe Ser Ile Arg Lys Ile Lys Gly Val Val 
1               5                   10                  15      

Gly Ser Val Phe Leu Gly Ser Leu Leu Met Ala Pro Ser Val Val Asp 
            20                  25                  30          

Ala Ala Thr Tyr His Tyr Val Asn Lys Glu Ile Ile Ser Gln Glu Ala 
        35                  40                  45              

Lys Asp Leu Ile Gln Thr Gly Lys Pro Asp Arg Asn Glu Val Val Tyr 
    50                  55                  60                  

Gly Leu Val Tyr Gln Lys Asp Gln Leu Pro Gln Thr Gly Thr Glu Ala 
65                  70                  75                  80  

Ser Val Leu Thr Ala Phe Gly Leu Leu Thr Val Gly Ser Leu Leu Leu 
                85                  90                  95      

Ile Tyr Lys Arg Lys Lys Ile Ala Ser Val Phe Leu Val Gly Thr Met 
            100                 105                 110         

Gly Leu Val Val Leu Pro Ser Ala Gly Ala Val Asp Pro Val Ala Thr 
        115                 120                 125             

Leu Ala Leu Ala Ser Arg Glu Gly Val Val Glu Met Glu Gly Tyr Arg 
    130                 135                 140                 

Tyr Val Gly Tyr Leu Ser Gly Asp Ile Leu Lys Thr Leu Gly Leu Asp 
145                 150                 155                 160 

Thr Val Leu Glu Glu Thr Ser Ala Lys Pro Gly Glu Val Thr Val Val 
                165                 170                 175     

Glu Val Glu Thr Pro Gln Ser Thr Thr Asn Gln Glu Gln Ala Arg Thr 
            180                 185                 190         

Glu Asn Gln Val Val Glu Thr Glu Glu Ala Pro Lys Glu Glu Ala Pro 
        195                 200                 205             

Lys Thr Glu Glu Ser Pro Lys Glu Glu Pro Lys Ser Glu Val Lys Pro 
    210                 215                 220                 

Thr Asp Asp Thr Leu Pro Lys Val Glu Glu Gly Lys Glu Asp Ser Ala 
225                 230                 235                 240 

Glu Pro Ala Pro Val Glu Glu Val Gly Gly Glu Val Glu Ser Lys Pro 
                245                 250                 255     

Glu Glu Lys Val Ala Val Lys Pro Glu Ser Gln Pro Ser Asp Lys Pro 
            260                 265                 270         

Ala Glu Glu Ser Lys Val Glu Gln Ala Gly Glu Pro Val Ala Pro Arg 
        275                 280                 285             

Lys Asp Glu Gln Ala Pro Val Glu Pro Glu Asn Gln Pro Glu Ala Pro 
    290                 295                 300                 

Glu Glu Glu Lys Ala Val Glu Glu Thr Pro Lys Gln Glu Glu Ser Thr 
305                 310                 315                 320 

Pro Asp Thr Lys Ala Glu Glu Thr Val Glu Pro Lys Glu Glu Thr Lys 
                325                 330                 335     

Thr Ala Lys Gly Thr Gln Glu Glu Gly Lys Glu Gly Gln Ala Pro Val 
            340                 345                 350         

Gln Glu Val Asn Pro Glu Tyr Lys Val Thr Thr Gly Thr Val Glu Lys 
        355                 360                 365             

Ser Thr Glu Ser Glu Leu Asp Phe Thr Thr Glu Val Val Pro Asp Asp 
    370                 375                 380                 

Thr Lys Tyr Val Asp Glu Glu Val Val Glu Arg Gln Gly Ser Lys Gly 
385                 390                 395                 400 

Val Gln Val Thr Lys Thr Thr Tyr Glu Thr Val Glu Val Val Glu Thr 
                405                 410                 415     

Asp Lys Val Leu Ser Thr Thr Thr Glu Val Lys Thr Pro Val Val Pro 
            420                 425                 430         

Lys Val Val Lys Lys Gly Thr Lys Pro Val Glu Thr Arg Glu Glu Val 
        435                 440                 445             

Ile Pro Phe Ala Thr Lys Glu Gln Glu Asp Asp Thr Leu Lys Arg Gly 
    450                 455                 460                 

Thr Arg Gln Val Ala Gln Glu Gly Val Asn Gly Lys Lys Gln Ile Thr 
465                 470                 475                 480 

Glu Thr Tyr Lys Thr Ile Arg Gly Glu Lys Thr Asn Glu Ala Pro Thr 
                485                 490                 495     

Val Glu Glu Thr Val Leu Gln Ala Pro Gln Asp Glu Ile Ile Lys Lys 
            500                 505                 510         

Gly Thr Lys Gly Leu Glu Lys Pro Thr Leu Gln Trp Ala Asn Thr Glu 
        515                 520                 525             

Lys Asp Val Leu Lys Lys Ser Ala Thr Ala Ser Tyr Thr Leu Thr Lys 
    530                 535                 540                 

Pro Ala Gly Val Glu Ile Lys Ser Ile Lys Leu Ala Leu Lys Asp Lys 
545                 550                 555                 560 

Asp Gly Gln Leu Val Lys Glu Val Thr Val Ala Glu Asn Asn Leu Asn 
                565                 570                 575     

Ala Thr Leu Asp Lys Leu Lys Tyr Tyr Gln Gly Tyr Thr Leu Ser Thr 
            580                 585                 590         

Thr Met Val Tyr Asp Arg Gly Glu Gly Glu Glu Thr Glu Lys Leu Glu 
        595                 600                 605             

Asp Lys Gln Ile Gln Leu Asp Leu Lys Lys Val Glu Ile Lys Asn Ile 
    610                 615                 620                 

Lys Glu Thr Ser Leu Met Asn Val Asp Ala Glu Gly Asn Glu Thr Asp 
625                 630                 635                 640 

Lys Ser Leu Leu Ser Glu Lys Pro Thr Asp Val Ser Gln Leu Tyr Leu 
                645                 650                 655     

Arg Val Thr Thr His Asp Asn Lys Val Thr Arg Leu Ala Val Ser Ser 
            660                 665                 670         

Val Glu Glu Val Val Val Asp Gly Lys Thr Leu Tyr Lys Val Val Ala 
        675                 680                 685             

Lys Ala Pro Asp Leu Val Gln Arg Arg Ala Asp Asp Thr Leu Ser Glu 
    690                 695                 700                 

Glu Tyr Val His Tyr Phe Glu Lys Gln Leu Pro Lys Val Asn Asn Val 
705                 710                 715                 720 

Tyr Tyr Asn Phe Asn Glu Leu Val Lys Asp Met Gln Ala Asn Pro Met 
                725                 730                 735     

Gly Glu Phe Lys Leu Gly Ala Asp Leu Asn Ala Val Asn Val Lys Pro 
            740                 745                 750         

Ala Gly Lys Ala Tyr Val Met Ala Lys Phe Arg Gly Thr Leu Ser Ser 
        755                 760                 765             

Val Glu Asn His Gln Tyr Thr Ile His Asn Leu Glu Arg Pro Leu Phe 
    770                 775                 780                 

Asn Glu Ala Glu Gly Ala Thr Leu Lys Asn Phe Asn Leu Gly Asn Val 
785                 790                 795                 800 

Asn Ile Asn Met Pro Trp Ala Asp Lys Val Ala Pro Ile Gly Asn Met 
                805                 810                 815     

Phe Lys Lys Ser Thr Leu Glu Asn Ile Lys Val Val Gly Ser Val Thr 
            820                 825                 830         

Gly Asn Asn Asp Val Thr Gly Ala Val Asn Lys Leu Asp Glu Ala Asn 
        835                 840                 845             

Met Arg Asn Val Ala Phe Ile Gly Lys Ile Asn Ser Leu Gly Asp Lys 
    850                 855                 860                 

Gly Trp Trp Ser Gly Gly Leu Val Ser Glu Ser Trp Arg Ser Asn Thr 
865                 870                 875                 880 

Asp Ser Val Tyr Phe Asp Gly Asp Ile Val Gly Asn Asn Ser Lys Phe 
                885                 890                 895     

Gly Gly Leu Val Ala Lys Val Asn His Gly Ser Asn Gln Trp Asp Val 
            900                 905                 910         

Lys Gln Lys Gly Arg Leu Thr Asn Ser Val Val Lys Gly Thr Met Thr 
        915                 920                 925             

Leu Lys Asn His Gly Gln Ser Gly Gly Leu Val His Glu Asn Tyr Asp 
    930                 935                 940                 

Trp Gly Trp Val Glu Asn Asn Ile Ser Met Met Lys Val Asn Asn Gly 
945                 950                 955                 960 

Glu Ile Met Tyr Gly Ser Gly Ser Ile Asp Gly Asp Pro Tyr Phe Gly 
                965                 970                 975     

Phe Asp Tyr Phe Lys Asn Asn Tyr Tyr Val Lys Asp Val Ala Thr Gly 
            980                 985                 990         

Glu Ser Thr Tyr Lys Arg Ser Lys Gln Ile Gln Ser Ile Ser Gln Ala 
        995                 1000                1005            

Glu Ala Asp Ala Lys Ile Ala Asn Met Gly Ile Thr Ala Asn Thr Phe 
    1010                1015                1020                

Ala Ile Gln Asp Pro Val Val Asn Lys Leu Asn Arg Ile Ile Asp Arg 
1025                1030                1035                1040

Asp Ser Glu Tyr Lys Ala Ile Gln Asp Tyr Gln Glu Thr Arg Asn Leu 
                1045                1050                1055    

Ala Tyr Arg Asn Leu Glu Lys Leu Gln Pro Phe Tyr Asn Lys Glu Trp 
            1060                1065                1070        

Ile Val Asn Gln Gly Asn Lys Leu Thr Asp Glu Ser Asn Leu Val Lys 
        1075                1080                1085            

Lys Thr Val Leu Ser Val Thr Gly Met Lys Ser Gly Gln Phe Val Thr 
    1090                1095                1100                

Asp Leu Ser Ser Val Asp Lys Ile Met Ile His Tyr Ala Asp Gly Thr 
1105                1110                1115                1120

Lys Glu Glu Phe Gly Val Ser Ala Ile Ser Asp Ser Arg Val Lys Gln 
                1125                1130                1135    

Val Lys Glu Tyr Asn Val Asp Asp Leu Gly Val Val Tyr Thr Pro Asn 
            1140                1145                1150        

Met Val Asp Lys Asn Arg Asp Ser Leu Ile Thr Lys Val Lys Glu Lys 
        1155                1160                1165            

Leu Ser Ser Val Ala Leu Asp Ser Ala Glu Val Lys Ser Ile Thr Asn 
    1170                1175                1180                

Asn Pro Ala Ser Leu Tyr Leu Glu Glu Ser Phe Ala Glu Val Arg Glu 
1185                1190                1195                1200

Thr Leu Asp Lys Leu Val Lys Ser Leu Leu Glu Asn Glu Asp His Gln 
                1205                1210                1215    

Leu Asn Ser Asp Glu Val Ala Glu Lys Ala Leu Leu Lys Lys Val Glu 
            1220                1225                1230        

Asp Asn Lys Ala Lys Ile Ile Leu Ala Leu Thr Tyr Leu Asn Arg Tyr 
        1235                1240                1245            

Tyr Gly Ile Asp Tyr Asp Gly Leu Asn Phe Lys His Leu Met Met Phe 
    1250                1255                1260                

Lys Pro Asp Phe Tyr Gly Lys Thr Pro Ser Ile Leu Asp Phe Leu Ile 
1265                1270                1275                1280

Arg Ile Gly Ser Ala Glu Lys Asn Leu Lys Gly Asp Arg Ser Leu Glu 
                1285                1290                1295    

Ala Tyr Arg Glu Val Ile Gly Gly Thr Ile Gly Lys Gly Glu Leu Asn 
            1300                1305                1310        

Gly Leu Leu Gly Tyr Asn Met Arg Leu Phe Thr Lys Tyr Thr Asp Leu 
        1315                1320                1325            

Asn Asp Trp Phe Ile His Ala Ala Lys Asn Val Tyr Val Ser Glu Pro 
    1330                1335                1340                

Glu Thr Thr Thr Glu Asp Phe Lys Asp Lys Arg His Arg Ile Tyr Asp 
1345                1350                1355                1360

Gly Leu Asn Asn Asp Val His Gly Arg Met Ile Leu Pro Leu Leu Asn 
                1365                1370                1375    

Leu Lys Lys Ala His Ile Phe Val Ile Ser Thr Tyr Asn Thr Ile Ala 
            1380                1385                1390        

Phe Ser Ser Phe Glu Lys Tyr Gly Lys Asn Thr Glu Glu Glu Arg Asn 
        1395                1400                1405            

Ala Tyr Lys Ala Glu Ile Asp Arg Val Ala Lys Ala Gln Gln Arg Tyr 
    1410                1415                1420                

Leu Asp Phe Trp Ser Arg Leu Ala Leu Pro Lys Val Arg Asn Gln Leu 
1425                1430                1435                1440

Leu Lys Ser Gln Asn Ser Val Pro Thr Pro Val Trp Asp Asn Gln Val 
                1445                1450                1455    

Tyr Val Gly Leu Gly Gly Ala Asn Arg Met Gly Tyr Gly Asp Gly Gly 
            1460                1465                1470        

Arg Val Val Thr Pro Val Arg Glu Leu Phe Gly Pro Thr Asp Arg Trp 
        1475                1480                1485            

His Gln Ile Asn Trp Asn Met Gly Ala Met Ala Lys Ile Tyr Glu Arg 
    1490                1495                1500                

Pro Trp Lys Asp Asp Gln Val Tyr Phe Met Val Thr Asn Met Met Glu 
1505                1510                1515                1520

Pro Phe Gly Ile Ser Ala Phe Thr His Glu Thr Thr His Val Asn Asp 
                1525                1530                1535    

Arg Met Ala Tyr Tyr Gly Gly Asp Trp His Arg Glu Gly Thr Asp Leu 
            1540                1545                1550        

Glu Ala Phe Ala Gln Gly Met Leu Gln Thr Pro Asp Lys Ser Thr Thr 
        1555                1560                1565            

Asn Gly Glu Tyr Gly Ala Leu Gly Ile Asn Met Ala Tyr Glu Arg Lys 
    1570                1575                1580                

Asn Asp Gly Glu Gln Leu Tyr Asn Tyr Asp Pro Glu Lys Leu Asp Ser 
1585                1590                1595                1600

Arg Glu Lys Ile Asp Ser Tyr Met Lys Asn Tyr Asn Glu Ser Met Met 
                1605                1610                1615    

Met Leu Asp Tyr Leu Glu Ala Ser Ala Val Ile Arg Gln Asn Leu Ser 
            1620                1625                1630        

Asp Asn Ser Lys Trp Phe Lys Lys Met Asp Lys Glu Trp Arg Thr Asn 
        1635                1640                1645            

Ala Asp Arg Asn Arg Leu Ile Gly Glu Pro His Gln Trp Asp Lys Leu 
    1650                1655                1660                

Arg Asp Leu Thr Glu Glu Glu Lys Lys Leu Pro Ile Asp Ser Ile Asp 
1665                1670                1675                1680

Lys Leu Val Glu Asn Asn Phe Val Thr Leu His Gly Met Pro Lys Asn 
                1685                1690                1695    

Gly Arg Tyr Arg Thr Glu Gly Phe Asp Ser Ser Tyr Gln Pro Val Asn 
            1700                1705                1710        

Met Met Ala Gly Val Phe Gly Gly Asn Thr Ser Lys Ser Thr Val Gly 
        1715                1720                1725            

Ser Ile Ser Phe Lys His Asn Ala Phe Arg Met Trp Gly Tyr Tyr Gly 
    1730                1735                1740                

Tyr Glu Asn Gly Phe Ile Pro Tyr Val Ser Asn Lys Leu Lys Gly Ala 
1745                1750                1755                1760

Ala Asn Lys Glu Asn Lys Gly Leu Leu Gly Asp Asp Phe Ile Ile Lys 
                1765                1770                1775    

Lys Val Ser Lys Asn Gln Phe Gln Asn Leu Glu Glu Trp Lys Lys His 
            1780                1785                1790        

Trp Tyr His Glu Val Tyr Asp Lys Ala Gln Lys Gly Phe Val Glu Ile 
        1795                1800                1805            

Glu Val Asp Gly Val Lys Ile Ser Thr Tyr Ala Gln Leu Gln Ser Leu 
    1810                1815                1820                

Phe Glu Glu Ala Val Ser Lys Asp Leu Ala Gly Met Asp Asp Lys Asn 
1825                1830                1835                1840

Ile Lys Asn His Tyr Gln Tyr Thr Glu Asn Leu Lys Trp Lys Ile Tyr 
                1845                1850                1855    

Lys Gln Leu Leu Lys Asn Thr Asp Gly Phe Ser Ser Asp Leu Phe Thr 
            1860                1865                1870        

Ala Pro Gln Ala 
        1875    

<210>   65
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length CbpD

<400>   65
Met Lys Ile Leu Pro Phe Ile Ala Arg Gly Thr Ser Tyr Tyr Leu Lys 
1               5                   10                  15      

Met Ser Val Lys Lys Leu Val Pro Phe Leu Val Val Gly Leu Met Leu 
            20                  25                  30          

Ala Ala Gly Asp Ser Val Tyr Ala Tyr Ser Arg Gly Asn Gly Ser Ile 
        35                  40                  45              

Ala Arg Gly Asp Asp Tyr Pro Ala Tyr Tyr Lys Asn Gly Ser Gln Glu 
    50                  55                  60                  

Ile Asp Gln Trp Arg Met Tyr Ser Arg Gln Cys Thr Ser Phe Val Ala 
65                  70                  75                  80  

Phe Arg Leu Ser Asn Val Asn Gly Phe Glu Ile Pro Ala Ala Tyr Gly 
                85                  90                  95      

Asn Ala Asn Glu Trp Gly His Arg Ala Arg Arg Glu Gly Tyr Arg Val 
            100                 105                 110         

Asp Asn Thr Pro Thr Ile Gly Ser Ile Thr Trp Ser Thr Ala Gly Thr 
        115                 120                 125             

Tyr Gly His Val Ala Trp Val Ser Asn Val Met Gly Asp Gln Ile Glu 
    130                 135                 140                 

Ile Glu Glu Tyr Asn Tyr Gly Tyr Thr Glu Ser Tyr Asn Lys Arg Val 
145                 150                 155                 160 

Ile Lys Ala Asn Thr Met Thr Gly Phe Ile His Phe Lys Asp Leu Asp 
                165                 170                 175     

Ser Gly Ser Val Gly Asn Ser Gln Ser Ser Ala Ser Thr Gly Gly Thr 
            180                 185                 190         

His Tyr Phe Lys Thr Lys Ser Ala Ile Lys Thr Glu Pro Leu Val Ser 
        195                 200                 205             

Ala Thr Val Ile Asp Tyr Tyr Tyr Pro Gly Glu Lys Val His Tyr Asp 
    210                 215                 220                 

Gln Ile Leu Glu Lys Asp Gly Tyr Lys Trp Leu Ser Tyr Thr Ala Tyr 
225                 230                 235                 240 

Asn Gly Ser Tyr Arg Tyr Val Gln Leu Glu Ala Val Asn Lys Asn Pro 
                245                 250                 255     

Leu Gly Asn Ser Val Leu Ser Ser Thr Gly Gly Thr His Tyr Phe Lys 
            260                 265                 270         

Ile Lys Ser Ala Ile Lys Thr Glu Pro Leu Val Ser Ala Thr Val Ile 
        275                 280                 285             

Asp Tyr Tyr Tyr Pro Gly Glu Lys Val His Tyr Asp Gln Ile Leu Glu 
    290                 295                 300                 

Lys Asp Gly Tyr Lys Trp Leu Ser Tyr Thr Ala Tyr Asn Gly Ser Arg 
305                 310                 315                 320 

Arg Tyr Ile Gln Leu Glu Gly Val Thr Ser Ser Gln Asn Tyr Gln Asn 
                325                 330                 335     

Gln Ser Gly Asn Ile Ser Ser Tyr Gly Ser Asn Asn Ser Ser Thr Val 
            340                 345                 350         

Gly Trp Lys Lys Ile Asn Gly Ser Trp Tyr His Phe Lys Ser Asn Gly 
        355                 360                 365             

Ser Lys Ser Thr Gly Trp Leu Lys Asp Gly Ser Ser Trp Tyr Tyr Leu 
    370                 375                 380                 

Lys Leu Ser Gly Glu Met Gln Thr Gly Trp Leu Lys Glu Asn Gly Ser 
385                 390                 395                 400 

Trp Tyr Tyr Leu Gly Ser Ser Gly Ala Met Lys Thr Gly Trp Tyr Gln 
                405                 410                 415     

Val Ser Gly Glu Trp Tyr Tyr Ser Tyr Ser Ser Gly Ala Leu Ala Ile 
            420                 425                 430         

Asn Thr Thr Val Asp Gly Tyr Arg Val Asn Ser Asp Gly Glu Arg Val 
        435                 440                 445             


<210>   66
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   variant of SEQ ID NO: 65

<400>   66
Met Lys Ile Leu Pro Phe Ile Ala Arg Gly Thr Ser Tyr Tyr Leu Lys 
1               5                   10                  15      

Met Ser Val Lys Lys Leu Val Pro Phe Leu Val Val Gly Leu Met Leu 
            20                  25                  30          

Ala Ala Gly Asp Ser Val Tyr Ala Tyr Ser Arg Gly Asn Gly Ser Ile 
        35                  40                  45              

Ala Arg Gly Asp Asp Tyr Pro Ala Tyr Tyr Lys Asn Gly Ser Gln Glu 
    50                  55                  60                  

Ile Asp Gln Trp Arg Met Tyr Ser Arg Gln Cys Thr Ser Phe Val Ala 
65                  70                  75                  80  

Phe Arg Leu Ser Asn Val Asn Gly Phe Glu Ile Pro Ala Ala Tyr Gly 
                85                  90                  95      

Asn Ala Asn Glu Trp Gly His Arg Ala Arg Arg Glu Gly Tyr Arg Val 
            100                 105                 110         

Asp Asn Thr Pro Thr Ile Gly Ser Ile Thr Trp Ser Thr Ala Gly Thr 
        115                 120                 125             

Tyr Gly His Val Ala Trp Val Ser Asn Val Met Gly Asp Gln Ile Glu 
    130                 135                 140                 

Ile Glu Glu Tyr Asn Tyr Gly Tyr Thr Glu Ser Tyr Asn Lys Arg Val 
145                 150                 155                 160 

Ile Lys Ala Asn Thr Met Thr Gly Phe Ile His Phe Lys Asp Leu Asp 
                165                 170                 175     

Gly Gly Ser Val Gly Asn Ser Gln Ser Ser Thr Ser Thr Gly Gly Thr 
            180                 185                 190         

His Tyr Phe Lys Thr Lys Ser Ala Ile Lys Thr Glu Pro Leu Ala Ser 
        195                 200                 205             

Gly Thr Val Ile Asp Tyr Tyr Tyr Pro Gly Glu Lys Val His Tyr Asp 
    210                 215                 220                 

Gln Ile Leu Glu Lys Asp Gly Tyr Lys Trp Leu Ser Tyr Thr Ala Tyr 
225                 230                 235                 240 

Asn Gly Ser Tyr Arg Tyr Val Gln Leu Glu Ala Val Asn Lys Asn Pro 
                245                 250                 255     

Leu Gly Asn Ser Val Leu Ser Ser Thr Gly Gly Thr His Tyr Phe Lys 
            260                 265                 270         

Thr Lys Ser Ala Ile Lys Thr Glu Pro Leu Val Ser Ala Thr Val Ile 
        275                 280                 285             

Asp Tyr Tyr Tyr Pro Gly Glu Lys Val His Tyr Asp Gln Ile Leu Glu 
    290                 295                 300                 

Lys Asp Gly Tyr Lys Trp Leu Ser Tyr Thr Ala Tyr Asn Gly Ser Arg 
305                 310                 315                 320 

Arg Tyr Ile Gln Leu Glu Gly Val Thr Ser Ser Gln Asn Tyr Gln Asn 
                325                 330                 335     

Gln Ser Gly Asn Ile Ser Ser Tyr Gly Ser His Ser Ser Ser Thr Val 
            340                 345                 350         

Gly Trp Lys Lys Ile Asn Gly Ser Trp Tyr His Phe Lys Ser Asn Gly 
        355                 360                 365             

Ser Lys Ser Thr Gly Trp Leu Lys Asp Gly Ser Ser Trp Tyr Tyr Leu 
    370                 375                 380                 

Lys Leu Ser Gly Glu Met Gln Thr Gly Trp Leu Lys Glu Asn Gly Leu 
385                 390                 395                 400 

Trp Tyr Tyr Leu Gly Ser Ser Gly Ala Met Lys Thr Gly Trp Tyr Gln 
                405                 410                 415     

Val Ser Gly Lys Trp Tyr Tyr Ser Tyr Ser Ser Gly Ala Leu Ala Val 
            420                 425                 430         

Asn Thr Thr Val Asp Gly Tyr Arg Val Asn Ser Asp Gly Glu Arg Val 
        435                 440                 445             


<210>   67
<211>   42
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length CbpG

<400>   67
Met Leu Thr Asp Trp Gln Lys Val Asn Gly Asn Trp Tyr Tyr Leu Asn 
1               5                   10                  15      

Ser Asn Gly Ala Met Val Thr Gly Ser Gln Thr Ile Asp Gly Lys Val 
            20                  25                  30          

Tyr Asn Phe Ala Ser Ser Gly Glu Trp Ile 
        35                  40          

<210>   68
<211>   204
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PvaA

<400>   68
Met Phe Lys Arg Ile Arg Arg Val Leu Val Leu Ala Val Phe Leu Phe 
1               5                   10                  15      

Ala Gly Tyr Lys Ala Tyr Arg Val His Gln Asp Val Lys Gln Val Met 
            20                  25                  30          

Thr Tyr Gln Pro Met Val Arg Glu Ile Leu Ser Glu Gln Asp Thr Pro 
        35                  40                  45              

Ala Asn Glu Glu Leu Val Leu Ala Met Ile Tyr Thr Glu Thr Lys Gly 
    50                  55                  60                  

Lys Glu Gly Asp Val Met Gln Ser Ser Glu Ser Ala Ser Gly Ser Thr 
65                  70                  75                  80  

Asn Thr Ile Asn Asp Asn Ala Ser Ser Ile Arg Gln Gly Ile Gln Thr 
                85                  90                  95      

Leu Thr Gly Asn Leu Tyr Leu Ala Gln Lys Lys Gly Val Asp Ile Trp 
            100                 105                 110         

Thr Ala Val Gln Ala Tyr Asn Phe Gly Pro Ala Tyr Ile Asp Phe Ile 
        115                 120                 125             

Ala Gln Asn Gly Lys Glu Asn Thr Leu Ala Leu Ala Lys Gln Tyr Ser 
    130                 135                 140                 

Arg Glu Thr Val Ala Pro Leu Leu Gly Asn Arg Thr Gly Lys Thr Tyr 
145                 150                 155                 160 

Ser Tyr Ile His Pro Ile Ser Ile Phe His Gly Ala Glu Leu Tyr Val 
                165                 170                 175     

Asn Gly Gly Asn Tyr Tyr Tyr Ser Arg Gln Val Arg Leu Asn Leu Tyr 
            180                 185                 190         

Ile Ile Lys Cys Phe Thr Leu Phe Ser Thr Ser Gly 
        195                 200                 

<210>   69
<211>   339
<212>   PRT
<213>   Streptococcus pneumoniae phage CP1

<220>
<223>   full length CPL1

<400>   69
Met Val Lys Lys Asn Asp Leu Phe Val Asp Val Ser Ser His Asn Gly 
1               5                   10                  15      

Tyr Asp Ile Thr Gly Ile Leu Glu Gln Met Gly Thr Thr Asn Thr Ile 
            20                  25                  30          

Ile Lys Ile Ser Glu Ser Thr Thr Tyr Leu Asn Pro Cys Leu Ser Ala 
        35                  40                  45              

Gln Val Glu Gln Ser Asn Pro Ile Gly Phe Tyr His Phe Ala Arg Phe 
    50                  55                  60                  

Gly Gly Asp Val Ala Glu Ala Glu Arg Glu Ala Gln Phe Phe Leu Asp 
65                  70                  75                  80  

Asn Val Pro Met Gln Val Lys Tyr Leu Val Leu Asp Tyr Glu Asp Asp 
                85                  90                  95      

Pro Ser Gly Asp Ala Gln Ala Asn Thr Asn Ala Cys Leu Arg Phe Met 
            100                 105                 110         

Gln Met Ile Ala Asp Ala Gly Tyr Lys Pro Ile Tyr Tyr Ser Tyr Lys 
        115                 120                 125             

Pro Phe Thr His Asp Asn Val Asp Tyr Gln Gln Ile Leu Ala Gln Phe 
    130                 135                 140                 

Pro Asn Ser Leu Trp Ile Ala Gly Tyr Gly Leu Asn Asp Gly Thr Ala 
145                 150                 155                 160 

Asn Phe Glu Tyr Phe Pro Ser Met Asp Gly Ile Arg Trp Trp Gln Tyr 
                165                 170                 175     

Ser Ser Asn Pro Phe Asp Lys Asn Ile Val Leu Leu Asp Asp Glu Glu 
            180                 185                 190         

Asp Asp Lys Pro Lys Thr Ala Gly Thr Trp Lys Gln Asp Ser Lys Gly 
        195                 200                 205             

Trp Trp Phe Arg Arg Asn Asn Gly Ser Phe Pro Tyr Asn Lys Trp Glu 
    210                 215                 220                 

Lys Ile Gly Gly Val Trp Tyr Tyr Phe Asp Ser Lys Gly Tyr Cys Leu 
225                 230                 235                 240 

Thr Ser Glu Trp Leu Lys Asp Asn Glu Lys Trp Tyr Tyr Leu Lys Asp 
                245                 250                 255     

Asn Gly Ala Met Ala Thr Gly Trp Val Leu Val Gly Ser Glu Trp Tyr 
            260                 265                 270         

Tyr Met Asp Asp Ser Gly Ala Met Val Thr Gly Trp Val Lys Tyr Lys 
        275                 280                 285             

Asn Asn Trp Tyr Tyr Met Thr Asn Glu Arg Gly Asn Met Val Ser Asn 
    290                 295                 300                 

Glu Phe Ile Lys Ser Gly Lys Gly Trp Tyr Phe Met Asn Thr Asn Gly 
305                 310                 315                 320 

Glu Leu Ala Asp Asn Pro Ser Phe Thr Lys Glu Pro Asp Gly Leu Ile 
                325                 330                 335     

Thr Val Ala 
            

<210>   70
<211>   279
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IC23

<400>   70
Met Ala Val Met Ala Tyr Pro Leu Val Ser Arg Leu Tyr Tyr Arg Val 
1               5                   10                  15      

Glu Ser Asn Gln Gln Ile Ala Asp Phe Asp Lys Glu Lys Ala Thr Leu 
            20                  25                  30          

Asp Glu Ala Asp Ile Asp Glu Arg Met Lys Leu Ala Gln Ala Phe Asn 
        35                  40                  45              

Asp Ser Leu Asn Asn Val Val Ser Gly Asp Pro Trp Ser Glu Glu Met 
    50                  55                  60                  

Lys Lys Lys Gly Arg Ala Glu Tyr Ala Arg Met Leu Glu Ile His Glu 
65                  70                  75                  80  

Arg Met Gly His Val Glu Ile Pro Val Ile Asp Val Asp Leu Pro Val 
                85                  90                  95      

Tyr Ala Gly Thr Ala Glu Glu Val Leu Gln Gln Gly Ala Gly His Leu 
            100                 105                 110         

Glu Gly Thr Ser Leu Pro Ile Gly Gly Asn Ser Thr His Ala Val Ile 
        115                 120                 125             

Thr Ala His Thr Gly Leu Pro Thr Ala Lys Met Phe Thr Asp Leu Thr 
    130                 135                 140                 

Lys Leu Lys Val Gly Asp Lys Phe Tyr Val His Asn Ile Lys Glu Val 
145                 150                 155                 160 

Met Ala Tyr Gln Val Asp Gln Val Lys Val Ile Glu Pro Thr Asn Phe 
                165                 170                 175     

Asp Asp Leu Leu Ile Val Pro Gly His Asp Tyr Val Thr Leu Leu Thr 
            180                 185                 190         

Cys Thr Pro Tyr Met Ile Asn Thr His Arg Leu Leu Val Arg Gly His 
        195                 200                 205             

Arg Ile Pro Tyr Val Ala Glu Val Glu Glu Glu Phe Ile Ala Ala Asn 
    210                 215                 220                 

Lys Leu Ser His Leu Tyr Arg Tyr Leu Phe Tyr Val Ala Val Gly Leu 
225                 230                 235                 240 

Ile Val Ile Leu Leu Trp Ile Ile Arg Arg Leu Arg Lys Lys Lys Lys 
                245                 250                 255     

Gln Pro Glu Lys Ala Leu Lys Ala Leu Lys Ala Ala Arg Lys Glu Val 
            260                 265                 270         

Lys Val Glu Asp Gly Gln Gln 
        275                 

<210>   71
<211>   612
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length Hic

<400>   71
Met Phe Ala Phe Lys Lys Arg Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Phe Ser Ile Gly Val Ala Ser Val Ala Val Ala Ser Leu Phe Met Gly 
            20                  25                  30          

Ser Val Val His Ala Thr Glu Lys Glu Val Thr Thr Gln Val Ala Thr 
        35                  40                  45              

Ser Ser Asn Lys Ala Asn Lys Ser Gln Thr Glu His Met Lys Ala Ala 
    50                  55                  60                  

Lys Gln Val Asp Glu Tyr Ile Glu Lys Met Leu Ser Glu Ile Gln Leu 
65                  70                  75                  80  

Asp Arg Arg Lys His Thr Gln Asn Val Gly Leu Leu Thr Lys Leu Gly 
                85                  90                  95      

Ala Ile Lys Thr Glu Tyr Leu Arg Gly Leu Ser Val Ser Lys Glu Lys 
            100                 105                 110         

Ser Thr Ala Glu Leu Pro Ser Glu Ile Lys Glu Lys Leu Thr Ala Ala 
        115                 120                 125             

Phe Glu Gln Phe Lys Lys Asp Thr Leu Lys Ser Gly Lys Lys Val Ala 
    130                 135                 140                 

Glu Ala Gln Lys Lys Ala Lys Asp Gln Lys Glu Ala Lys Gln Glu Ile 
145                 150                 155                 160 

Glu Ala Leu Ile Val Lys His Lys Gly Arg Glu Ile Asp Leu Asp Arg 
                165                 170                 175     

Lys Lys Ala Lys Ala Ala Val Thr Glu His Leu Lys Lys Leu Leu Asn 
            180                 185                 190         

Asp Ile Glu Lys Asn Leu Lys Lys Glu Gln His Thr His Thr Val Glu 
        195                 200                 205             

Leu Ile Lys Asn Leu Lys Asp Ile Glu Lys Thr Tyr Leu His Lys Leu 
    210                 215                 220                 

Asp Glu Ser Thr Gln Lys Ala Gln Leu Gln Lys Leu Ile Ala Glu Ser 
225                 230                 235                 240 

Gln Ser Lys Leu Asp Glu Ala Phe Ser Lys Phe Lys Asn Gly Leu Ser 
                245                 250                 255     

Ser Ser Ser Asn Ser Gly Ser Ser Thr Lys Pro Glu Thr Pro Gln Pro 
            260                 265                 270         

Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro 
        275                 280                 285             

Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu 
    290                 295                 300                 

Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys 
305                 310                 315                 320 

Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro 
                325                 330                 335     

Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro 
            340                 345                 350         

Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys 
        355                 360                 365             

Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr 
    370                 375                 380                 

Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val 
385                 390                 395                 400 

Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu 
                405                 410                 415     

Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu 
            420                 425                 430         

Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro 
        435                 440                 445             

Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro 
    450                 455                 460                 

Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu 
465                 470                 475                 480 

Leu Glu Thr Pro Lys Gln Lys Val Lys Pro Glu Pro Glu Thr Pro Lys 
                485                 490                 495     

Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro 
            500                 505                 510         

Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Ile Pro 
        515                 520                 525             

Lys Pro Glu Val Lys Pro Asp Asn Ser Lys Pro Gln Ala Asp Asp Lys 
    530                 535                 540                 

Lys Pro Ser Thr Pro Asn Asn Leu Ser Lys Asp Lys Gln Ser Ser Asn 
545                 550                 555                 560 

Gln Ala Ser Thr Asn Glu Asn Lys Lys Gln Gly Pro Ala Thr Asn Lys 
                565                 570                 575     

Pro Lys Lys Ser Leu Pro Ser Thr Gly Ser Ile Ser Asn Leu Ala Leu 
            580                 585                 590         

Glu Ile Ala Gly Leu Leu Thr Leu Ala Gly Ala Thr Ile Leu Ala Lys 
        595                 600                 605             

Lys Arg Met Lys 
    610         

<210>   72
<211>   619
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PspA

<400>   72
Met Asn Lys Lys Lys Met Ile Leu Thr Ser Leu Ala Ser Val Ala Ile 
1               5                   10                  15      

Leu Gly Ala Gly Phe Val Ala Ser Gln Pro Thr Val Val Arg Ala Glu 
            20                  25                  30          

Glu Ser Pro Val Ala Ser Gln Ser Lys Ala Glu Lys Asp Tyr Asp Ala 
        35                  40                  45              

Ala Lys Lys Asp Ala Lys Asn Ala Lys Lys Ala Val Glu Asp Ala Gln 
    50                  55                  60                  

Lys Ala Leu Asp Asp Ala Lys Ala Ala Gln Lys Lys Tyr Asp Glu Asp 
65                  70                  75                  80  

Gln Lys Lys Thr Glu Glu Lys Ala Ala Leu Glu Lys Ala Ala Ser Glu 
                85                  90                  95      

Glu Met Asp Lys Ala Val Ala Ala Val Gln Gln Ala Tyr Leu Ala Tyr 
            100                 105                 110         

Gln Gln Ala Thr Asp Lys Ala Ala Lys Asp Ala Ala Asp Lys Met Ile 
        115                 120                 125             

Asp Glu Ala Lys Lys Arg Glu Glu Glu Ala Lys Thr Lys Phe Asn Thr 
    130                 135                 140                 

Val Arg Ala Met Val Val Pro Glu Pro Glu Gln Leu Ala Glu Thr Lys 
145                 150                 155                 160 

Lys Lys Ser Glu Glu Ala Lys Gln Lys Ala Pro Glu Leu Thr Lys Lys 
                165                 170                 175     

Leu Glu Glu Ala Lys Ala Lys Leu Glu Glu Ala Glu Lys Lys Ala Thr 
            180                 185                 190         

Glu Ala Lys Gln Lys Val Asp Ala Glu Glu Val Ala Pro Gln Ala Lys 
        195                 200                 205             

Ile Ala Glu Leu Glu Asn Gln Val His Arg Leu Glu Gln Glu Leu Lys 
    210                 215                 220                 

Glu Ile Asp Glu Ser Glu Ser Glu Asp Tyr Ala Lys Glu Gly Phe Arg 
225                 230                 235                 240 

Ala Pro Leu Gln Ser Lys Leu Asp Ala Lys Lys Ala Lys Leu Ser Lys 
                245                 250                 255     

Leu Glu Glu Leu Ser Asp Lys Ile Asp Glu Leu Asp Ala Glu Ile Ala 
            260                 265                 270         

Lys Leu Glu Asp Gln Leu Lys Ala Ala Glu Glu Asn Asn Asn Val Glu 
        275                 280                 285             

Asp Tyr Phe Lys Glu Gly Leu Glu Lys Thr Ile Ala Ala Lys Lys Ala 
    290                 295                 300                 

Glu Leu Glu Lys Thr Glu Ala Asp Leu Lys Lys Ala Val Asn Glu Pro 
305                 310                 315                 320 

Glu Lys Pro Ala Pro Ala Pro Glu Thr Pro Ala Pro Glu Ala Pro Ala 
                325                 330                 335     

Glu Gln Pro Lys Pro Ala Pro Ala Pro Gln Pro Ala Pro Ala Pro Lys 
            340                 345                 350         

Pro Glu Lys Pro Ala Glu Gln Pro Lys Pro Glu Lys Thr Asp Asp Gln 
        355                 360                 365             

Gln Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg 
    370                 375                 380                 

Leu Thr Gln Gln Gln Pro Pro Lys Ala Glu Lys Pro Ala Pro Ala Pro 
385                 390                 395                 400 

Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn Thr 
                405                 410                 415     

Asp Gly Ser Met Ala Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp Tyr 
            420                 425                 430         

Tyr Leu Asn Ser Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Tyr Asn 
        435                 440                 445             

Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp 
    450                 455                 460                 

Ala Lys Val Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala Met 
465                 470                 475                 480 

Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ala 
                485                 490                 495     

Asn Gly Ala Met Ala Thr Gly Trp Ala Lys Val Asn Gly Ser Trp Tyr 
            500                 505                 510         

Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Tyr Asn 
        515                 520                 525             

Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp 
    530                 535                 540                 

Ala Lys Val Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala Met 
545                 550                 555                 560 

Ala Thr Gly Trp Val Lys Asp Gly Asp Thr Trp Tyr Tyr Leu Glu Ala 
                565                 570                 575     

Ser Gly Ala Met Lys Ala Ser Gln Trp Phe Lys Val Ser Asp Lys Trp 
            580                 585                 590         

Tyr Tyr Val Asn Gly Leu Gly Ala Leu Ala Val Asn Thr Thr Val Asp 
        595                 600                 605             

Gly Tyr Lys Val Asn Ala Asn Gly Glu Trp Val 
    610                 615                 

<210>   73
<211>   309
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PsaA

<400>   73
Met Lys Lys Leu Gly Thr Leu Leu Val Leu Phe Leu Ser Ala Ile Ile 
1               5                   10                  15      

Leu Val Ala Cys Ala Ser Gly Lys Lys Asp Thr Thr Ser Gly Gln Lys 
            20                  25                  30          

Leu Lys Val Val Ala Thr Asn Ser Ile Ile Ala Asp Ile Thr Lys Asn 
        35                  40                  45              

Ile Ala Gly Asp Lys Ile Asp Leu His Ser Ile Val Pro Ile Gly Gln 
    50                  55                  60                  

Asp Pro His Glu Tyr Glu Pro Leu Pro Glu Asp Val Lys Lys Thr Ser 
65                  70                  75                  80  

Glu Ala Asp Leu Ile Phe Tyr Asn Gly Ile Asn Leu Glu Thr Gly Gly 
                85                  90                  95      

Asn Ala Trp Phe Thr Lys Leu Val Glu Asn Ala Lys Lys Thr Glu Asn 
            100                 105                 110         

Lys Asp Tyr Phe Ala Val Ser Asp Gly Val Asp Val Ile Tyr Leu Glu 
        115                 120                 125             

Gly Gln Asn Glu Lys Gly Lys Glu Asp Pro His Ala Trp Leu Asn Leu 
    130                 135                 140                 

Glu Asn Gly Ile Ile Phe Ala Lys Asn Ile Ala Lys Gln Leu Ser Ala 
145                 150                 155                 160 

Lys Asp Pro Asn Asn Lys Glu Phe Tyr Glu Lys Asn Leu Lys Glu Tyr 
                165                 170                 175     

Thr Asp Lys Leu Asp Lys Leu Asp Lys Glu Ser Lys Asp Lys Phe Asn 
            180                 185                 190         

Lys Ile Pro Ala Glu Lys Lys Leu Ile Val Thr Ser Glu Gly Ala Phe 
        195                 200                 205             

Lys Tyr Phe Ser Lys Ala Tyr Gly Val Pro Ser Ala Tyr Ile Trp Glu 
    210                 215                 220                 

Ile Asn Thr Glu Glu Glu Gly Thr Pro Glu Gln Ile Lys Thr Leu Val 
225                 230                 235                 240 

Glu Lys Leu Arg Gln Thr Lys Val Pro Ser Leu Phe Val Glu Ser Ser 
                245                 250                 255     

Val Asp Asp Arg Pro Met Lys Thr Val Ser Gln Asp Thr Asn Ile Pro 
            260                 265                 270         

Ile Tyr Ala Gln Ile Phe Thr Asp Ser Ile Ala Glu Gln Gly Lys Glu 
        275                 280                 285             

Gly Asp Ser Tyr Tyr Ser Met Met Lys Tyr Asn Leu Asp Lys Ile Ala 
    290                 295                 300                 

Glu Gly Leu Ala Lys 
305                 

<210>   74
<211>   2144
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PrtA

<400>   74
Met Lys Lys Ser Thr Val Leu Ser Leu Thr Thr Ala Ala Val Ile Leu 
1               5                   10                  15      

Ala Ala Tyr Ala Pro Asn Glu Val Val Leu Ala Asp Thr Ser Ser Ser 
            20                  25                  30          

Glu Asp Ala Leu Ser Ile Ser Asp Lys Glu Lys Val Val Val Asp Lys 
        35                  40                  45              

Glu Thr Glu Asn Lys Glu Lys His Lys Asp Ile His Asn Ala Ile Glu 
    50                  55                  60                  

Thr Ser Lys Asp Thr Glu Glu Lys Lys Thr Thr Ile Ile Glu Glu Lys 
65                  70                  75                  80  

Glu Val Val Ser Lys Asn Pro Val Ile Asp Thr Lys Thr Ser Asn Glu 
                85                  90                  95      

Glu Ala Lys Ile Lys Glu Glu Asn Ser Asn Gln Ser Gln Gly Asp His 
            100                 105                 110         

Thr Asp Ser Phe Val Asn Lys Asn Thr Glu Asn Pro Lys Lys Glu Asp 
        115                 120                 125             

Lys Val Val Tyr Ile Ala Glu Phe Lys Asp Lys Glu Ser Gly Glu Lys 
    130                 135                 140                 

Ala Ile Lys Gly Leu Ser Asn Leu Lys Asn Thr Lys Val Leu Tyr Thr 
145                 150                 155                 160 

Tyr Asp Arg Ile Phe Asn Gly Ser Ala Ile Glu Thr Thr Pro Asp Asn 
                165                 170                 175     

Leu Asp Lys Ile Lys Gln Ile Glu Gly Ile Ser Ser Ile Glu Arg Ala 
            180                 185                 190         

Gln Lys Val Gln Pro Met Met Asn His Ala Arg Lys Glu Ile Gly Val 
        195                 200                 205             

Glu Glu Ala Ile Asp Tyr Leu Lys Ser Ile Asn Ala Pro Phe Gly Lys 
    210                 215                 220                 

Asn Phe Asp Gly Arg Gly Met Val Ile Ser Asn Ile Asp Thr Gly Thr 
225                 230                 235                 240 

Asp Tyr Arg His Lys Ala Met Arg Ile Asp Asp Asp Ala Lys Ala Ser 
                245                 250                 255     

Met Arg Phe Lys Lys Glu Asp Leu Lys Gly Thr Asp Lys Asn Tyr Trp 
            260                 265                 270         

Leu Ser Asp Lys Ile Pro His Ala Phe Asn Tyr Tyr Asn Gly Gly Lys 
        275                 280                 285             

Ile Thr Val Glu Lys Tyr Asp Asp Gly Arg Asp Tyr Phe Asp Pro His 
    290                 295                 300                 

Gly Met His Ile Ala Gly Ile Leu Ala Gly Asn Asp Thr Glu Gln Asp 
305                 310                 315                 320 

Ile Lys Asn Phe Asn Gly Ile Asp Gly Ile Ala Pro Asn Ala Gln Ile 
                325                 330                 335     

Phe Ser Tyr Lys Met Tyr Ser Asp Ala Gly Ser Gly Phe Ala Gly Asp 
            340                 345                 350         

Glu Thr Met Phe His Ala Ile Glu Asp Ser Ile Lys His Asn Val Asp 
        355                 360                 365             

Val Val Ser Val Ser Ser Gly Phe Thr Gly Thr Gly Leu Val Gly Glu 
    370                 375                 380                 

Lys Tyr Trp Gln Ala Ile Arg Ala Leu Arg Lys Ala Gly Ile Pro Met 
385                 390                 395                 400 

Val Val Ala Thr Gly Asn Tyr Ala Thr Ser Ala Ser Ser Ser Ser Trp 
                405                 410                 415     

Asp Leu Val Ala Asn Asn His Leu Lys Met Thr Asp Thr Gly Asn Val 
            420                 425                 430         

Thr Arg Thr Ala Ala His Glu Asp Ala Ile Ala Val Ala Ser Ala Lys 
        435                 440                 445             

Asn Gln Thr Val Glu Phe Asp Lys Val Asn Ile Gly Gly Glu Ser Phe 
    450                 455                 460                 

Lys Tyr Arg Asn Ile Gly Ala Phe Phe Asp Lys Asn Lys Ile Thr Thr 
465                 470                 475                 480 

Asn Glu Asp Gly Thr Lys Ala Pro Ser Lys Leu Lys Phe Val Tyr Ile 
                485                 490                 495     

Gly Lys Gly Gln Asp Gln Asp Leu Ile Gly Leu Asp Leu Arg Gly Lys 
            500                 505                 510         

Ile Ala Val Met Asp Arg Ile Tyr Thr Lys Asp Leu Lys Asn Ala Phe 
        515                 520                 525             

Lys Lys Ala Met Asp Lys Gly Ala Arg Ala Ile Met Val Val Asn Thr 
    530                 535                 540                 

Val Asn Tyr Tyr Asn Arg Asp Asn Trp Thr Glu Leu Pro Ala Met Gly 
545                 550                 555                 560 

Tyr Glu Ala Asp Glu Gly Thr Lys Ser Gln Val Phe Ser Ile Ser Gly 
                565                 570                 575     

Asp Asp Gly Val Lys Leu Trp Asn Met Ile Asn Pro Asp Lys Lys Thr 
            580                 585                 590         

Glu Val Lys Arg Asn Asn Lys Glu Asp Phe Lys Asp Lys Leu Glu Gln 
        595                 600                 605             

Tyr Tyr Pro Ile Asp Met Glu Ser Phe Asn Ser Asn Lys Pro Asn Val 
    610                 615                 620                 

Gly Asp Glu Lys Glu Ile Asp Phe Lys Phe Ala Pro Asp Thr Asp Lys 
625                 630                 635                 640 

Glu Leu Tyr Lys Glu Asp Ile Ile Val Pro Ala Gly Ser Thr Ser Trp 
                645                 650                 655     

Gly Pro Arg Ile Asp Leu Leu Leu Lys Pro Asp Val Ser Ala Pro Gly 
            660                 665                 670         

Lys Asn Ile Lys Ser Thr Leu Asn Val Ile Asn Gly Lys Ser Thr Tyr 
        675                 680                 685             

Gly Tyr Met Ser Gly Thr Ser Met Ala Thr Pro Ile Val Ala Ala Ser 
    690                 695                 700                 

Thr Val Leu Ile Arg Pro Lys Leu Lys Glu Met Leu Glu Arg Pro Val 
705                 710                 715                 720 

Leu Lys Asn Leu Lys Gly Asp Asp Lys Ile Asp Leu Thr Ser Leu Thr 
                725                 730                 735     

Lys Ile Ala Leu Gln Asn Thr Ala Arg Pro Met Met Asp Ala Thr Ser 
            740                 745                 750         

Trp Lys Glu Lys Ser Gln Tyr Phe Ala Ser Pro Arg Gln Gln Gly Ala 
        755                 760                 765             

Gly Leu Ile Asn Val Ala Asn Ala Leu Arg Asn Glu Val Val Ala Thr 
    770                 775                 780                 

Phe Lys Asn Thr Asp Ser Lys Gly Leu Val Asn Ser Tyr Gly Ser Ile 
785                 790                 795                 800 

Ser Leu Lys Glu Ile Lys Gly Asp Lys Lys Tyr Phe Thr Ile Lys Leu 
                805                 810                 815     

His Asn Thr Ser Asn Arg Pro Leu Thr Phe Lys Val Ser Ala Ser Ala 
            820                 825                 830         

Ile Thr Thr Asp Ser Leu Thr Asp Arg Leu Lys Leu Asp Glu Thr Tyr 
        835                 840                 845             

Lys Asp Glu Lys Ser Pro Asp Gly Lys Gln Ile Val Pro Glu Ile His 
    850                 855                 860                 

Pro Glu Lys Val Lys Gly Ala Asn Ile Thr Phe Glu His Gly Thr Phe 
865                 870                 875                 880 

Thr Ile Gly Ala Asn Ser Ser Phe Asp Leu Asn Ala Val Ile Asn Val 
                885                 890                 895     

Gly Glu Ala Lys Asn Lys Asn Lys Phe Val Glu Ser Phe Ile His Phe 
            900                 905                 910         

Glu Ser Val Glu Glu Met Glu Ala Leu Asn Ser Asn Gly Lys Lys Ile 
        915                 920                 925             

Asn Phe Gln Pro Ser Leu Ser Met Pro Leu Met Gly Phe Ala Gly Asn 
    930                 935                 940                 

Trp Asn His Glu Pro Ile Leu Asp Lys Trp Ala Trp Glu Glu Gly Ser 
945                 950                 955                 960 

Arg Ser Lys Thr Leu Gly Gly Tyr Asp Asp Asp Gly Lys Pro Lys Ile 
                965                 970                 975     

Pro Gly Thr Leu Asn Lys Gly Ile Gly Gly Glu His Gly Ile Asp Lys 
            980                 985                 990         

Phe Asn Pro Ala Gly Val Ile Gln Asn Arg Lys Asp Lys Asn Thr Thr 
        995                 1000                1005            

Ser Leu Asp Gln Asn Pro Glu Leu Phe Ala Phe Asn Asn Gln Gly Ile 
    1010                1015                1020                

Asn Ala Pro Ser Ser Ser Gly Ser Lys Ile Ala Asn Ile Tyr Pro Leu 
1025                1030                1035                1040

Asp Ser Asn Gly Asn Pro Gln Asp Ala Gln Leu Glu Arg Gly Leu Thr 
                1045                1050                1055    

Pro Ser Pro Leu Val Leu Arg Ser Ala Glu Glu Gly Leu Ile Ser Ile 
            1060                1065                1070        

Val Asn Thr Asn Lys Glu Gly Glu Asn Gln Arg Asp Leu Lys Val Ile 
        1075                1080                1085            

Ser Arg Glu His Phe Ile Arg Gly Ile Leu Asn Ser Lys Ser Asn Asp 
    1090                1095                1100                

Ala Lys Gly Ile Lys Ser Ser Lys Leu Lys Val Trp Gly Asp Leu Lys 
1105                1110                1115                1120

Trp Asp Gly Leu Ile Tyr Asn Pro Arg Gly Arg Glu Glu Asn Ala Pro 
                1125                1130                1135    

Glu Ser Lys Asp Asn Gln Asp Pro Ala Thr Lys Ile Arg Gly Gln Phe 
            1140                1145                1150        

Glu Pro Ile Ala Glu Gly Gln Tyr Phe Tyr Lys Phe Lys Tyr Arg Leu 
        1155                1160                1165            

Thr Lys Asp Tyr Pro Trp Gln Val Ser Tyr Ile Pro Val Lys Ile Asp 
    1170                1175                1180                

Asn Thr Ala Pro Lys Ile Val Ser Val Asp Phe Ser Asn Pro Glu Lys 
1185                1190                1195                1200

Ile Lys Leu Ile Thr Lys Asp Thr Tyr His Lys Val Lys Asp Gln Tyr 
                1205                1210                1215    

Lys Asn Glu Thr Leu Phe Ala Arg Asp Gln Lys Glu His Pro Glu Lys 
            1220                1225                1230        

Phe Asp Glu Ile Ala Asn Glu Val Trp Tyr Ala Gly Ala Ala Leu Val 
        1235                1240                1245            

Asn Glu Asp Gly Glu Val Glu Lys Asn Leu Glu Val Thr Tyr Ala Gly 
    1250                1255                1260                

Glu Gly Gln Gly Arg Asn Arg Lys Leu Asp Lys Asp Gly Asn Thr Ile 
1265                1270                1275                1280

Tyr Glu Ile Lys Gly Ala Gly Asp Leu Arg Gly Lys Ile Ile Glu Val 
                1285                1290                1295    

Ile Ala Leu Asp Gly Ser Ser Asn Phe Thr Lys Ile His Arg Ile Lys 
            1300                1305                1310        

Phe Ala Asp Gln Ala Asp Glu Lys Gly Met Ile Ser Tyr Tyr Leu Val 
        1315                1320                1325            

Asp Pro Asp Lys Asp Ala Ser Lys Tyr Glu Lys Leu Gly Glu Ile Ser 
    1330                1335                1340                

Glu Asp Lys Leu Lys Asn Ala Lys Ser Pro Glu Glu Asn Thr Asn Asn 
1345                1350                1355                1360

Asn Gln Ala Lys Asp Glu Asp Ser Lys Pro Asp Glu Lys Ser Ser Val 
                1365                1370                1375    

Glu Gly Glu Ala Ser Leu Glu Ile Asn Lys Thr Ile Ser Thr Ile Arg 
            1380                1385                1390        

Glu Phe Glu Asn Lys Asp Leu Lys Lys Leu Ile Lys Lys Lys Phe Arg 
        1395                1400                1405            

Glu Val Asn Asp Phe Thr Ser Glu Thr Gly Lys Arg Ile Glu Glu Tyr 
    1410                1415                1420                

Asp Tyr Lys Tyr Asp Asp Lys Gly Asn Ile Ile Ala Tyr Asp Asp Gly 
1425                1430                1435                1440

Ser Ala Leu Gln Tyr Glu Thr Glu Lys Phe Asp Glu Ile Lys Ser Lys 
                1445                1450                1455    

Ile Tyr Gly Val Leu Ser Pro Ser Lys Asp Gly His Phe Glu Ile Leu 
            1460                1465                1470        

Gly Lys Ile Ser Asn Val Ser Lys Asn Ala Lys Val Tyr Tyr Gly Asn 
        1475                1480                1485            

Ser Tyr Lys Ser Ile Glu Ile Lys Ala Thr Lys Tyr Asp Ser His Ser 
    1490                1495                1500                

Lys Thr Met Ile Phe Asp Leu Tyr Ala Asn Ile Asn Asp Ile Val Asp 
1505                1510                1515                1520

Gly Leu Ala Phe Ala Gly Asp Met Arg Leu Phe Val Lys Asp Asp Asn 
                1525                1530                1535    

Gln Ile Lys Ala Glu Thr Lys Ile Arg Met Pro Glu Lys Asn Lys Glu 
            1540                1545                1550        

Thr Lys Ala Glu Tyr Pro Tyr Val Ser Ser Tyr Gly Asn Val Ile Glu 
        1555                1560                1565            

Leu Gly Glu Gly Asp Leu Ser Lys Asn Lys Pro Asp Asn Leu Thr Lys 
    1570                1575                1580                

Met Glu Ser Gly Lys Ile Tyr Ser Asp Ser Glu Lys Gln Gln Tyr Leu 
1585                1590                1595                1600

Leu Lys Asp Asn Ile Ile Leu Arg Lys Gly Tyr Ala Leu Lys Val Thr 
                1605                1610                1615    

Thr Tyr Asn Pro Gly Lys Thr Asp Met Leu Glu Gly Asn Gly Val Tyr 
            1620                1625                1630        

Ser Lys Glu Asp Ile Ala Lys Ile Gln Lys Ala Asn Pro Asn Leu Arg 
        1635                1640                1645            

Val Leu Ser Glu Thr Thr Ile Tyr Ala Asp Ser Arg Asn Val Glu Asp 
    1650                1655                1660                

Gly Arg Ser Thr Gln Ala Val Leu Met Ser Ala Leu Asp Gly Phe Asn 
1665                1670                1675                1680

Ile Ile Arg Tyr Gln Val Phe Thr Phe Lys Met Asn Asp Lys Gly Glu 
                1685                1690                1695    

Ala Ile Asp Lys Asp Gly Asn Leu Val Thr Asp Ser Ser Lys Leu Val 
            1700                1705                1710        

Leu Phe Gly Lys Asp Asp Lys Glu Tyr Thr Gly Glu Asp Lys Ser Asn 
        1715                1720                1725            

Val Glu Ala Ile Lys Glu Asp Gly Ser Met Leu Phe Ile Asp Thr Lys 
    1730                1735                1740                

Pro Val Asn Leu Ser Met Asp Lys Asn Tyr Phe Asn Pro Ser Lys Ser 
1745                1750                1755                1760

Asn Lys Ile Tyr Val Arg Asn Pro Glu Phe Tyr Leu Arg Gly Lys Ile 
                1765                1770                1775    

Ser Asp Lys Gly Gly Phe Asn Trp Glu Leu Arg Val Asn Glu Ser Val 
            1780                1785                1790        

Val Asp Asn Tyr Leu Ile Tyr Gly Asp Leu His Ile Asp Asn Thr Arg 
        1795                1800                1805            

Asp Phe Asn Ile Lys Leu Asn Val Lys Asp Gly Asp Ile Met Asp Trp 
    1810                1815                1820                

Gly Met Lys Asp Tyr Lys Ala Asn Gly Phe Pro Asp Lys Val Thr Asp 
1825                1830                1835                1840

Met Asp Gly Asn Val Tyr Leu Gln Thr Gly Tyr Ser Asp Leu Asn Ala 
                1845                1850                1855    

Lys Ala Val Gly Val His Tyr Gln Phe Leu Tyr Asp Asn Val Lys Pro 
            1860                1865                1870        

Glu Val Asn Ile Asp Pro Lys Gly Asn Thr Ser Ile Glu Tyr Ala Asp 
        1875                1880                1885            

Gly Lys Ser Val Val Phe Asn Ile Asn Asp Lys Arg Asn Asn Gly Phe 
    1890                1895                1900                

Asp Gly Glu Ile Gln Glu Gln His Ile Tyr Val Asn Gly Lys Glu Tyr 
1905                1910                1915                1920

Thr Ser Phe Asp Asp Ile Lys Gln Ile Thr Asp Lys Thr Leu Asn Ile 
                1925                1930                1935    

Lys Ile Val Val Lys Asp Phe Ala Arg Asn Thr Thr Val Lys Glu Phe 
            1940                1945                1950        

Ile Leu Asn Lys Asp Thr Gly Glu Val Ser Glu Leu Lys Pro His Arg 
        1955                1960                1965            

Val Thr Val Thr Ile Gln Asn Gly Lys Glu Met Ser Ser Thr Ile Val 
    1970                1975                1980                

Ser Glu Glu Asp Phe Ile Leu Pro Val Tyr Lys Gly Glu Leu Glu Lys 
1985                1990                1995                2000

Gly Tyr Gln Phe Asp Gly Trp Glu Ile Ser Gly Phe Glu Gly Lys Lys 
                2005                2010                2015    

Asp Ala Gly Tyr Val Ile Asn Leu Ser Lys Asp Thr Phe Ile Lys Pro 
            2020                2025                2030        

Val Phe Lys Lys Ile Glu Glu Lys Lys Glu Glu Glu Asn Lys Pro Thr 
        2035                2040                2045            

Phe Asp Val Ser Lys Lys Lys Asp Asn Pro Gln Val Asn His Ser Gln 
    2050                2055                2060                

Leu Asn Glu Ser His Arg Lys Glu Asp Leu Gln Arg Glu Asp His Ser 
2065                2070                2075                2080

Gln Lys Ser Asp Ser Thr Lys Asp Val Thr Ala Thr Val Leu Asp Lys 
                2085                2090                2095    

Asn Asn Ile Ser Ser Lys Ser Thr Thr Asn Asn Pro Asn Lys Leu Pro 
            2100                2105                2110        

Lys Thr Gly Thr Ala Ser Gly Ala Gln Thr Leu Leu Ala Ala Gly Ile 
        2115                2120                2125            

Met Phe Ile Val Gly Ile Phe Leu Gly Leu Lys Lys Lys Asn Gln Asp 
    2130                2135                2140                


<210>   75
<211>   324
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length Sp133

<400>   75
Met Arg Lys Lys Leu Phe Leu Thr Ser Ala Ala Ile Leu Trp Ala Val 
1               5                   10                  15      

Thr Ala Met Asn Ser Val His Ala Ala Thr Asp Val Gln Lys Val Ile 
            20                  25                  30          

Asp Glu Thr Tyr Val Gln Pro Glu Tyr Val Leu Gly Ser Ser Leu Ser 
        35                  40                  45              

Glu Asp Gln Lys Asn Gln Thr Leu Lys Lys Leu Gly Tyr Asn Ala Ser 
    50                  55                  60                  

Thr Asp Thr Lys Glu Leu Lys Thr Met Thr Pro Asp Val Tyr Ser Lys 
65                  70                  75                  80  

Ile Met Asn Val Ala Asn Asp Ser Ser Leu Gln Leu Tyr Ser Ser Ala 
                85                  90                  95      

Lys Ile Gln Lys Leu Gly Asp Lys Ser Pro Leu Glu Val Lys Ile Glu 
            100                 105                 110         

Thr Pro Glu Asn Ile Thr Lys Val Thr Gln Asp Met Tyr Arg Asn Ala 
        115                 120                 125             

Ala Val Thr Leu Gly Val Glu His Ala Lys Ile Thr Val Ala Ala Pro 
    130                 135                 140                 

Ile Pro Val Thr Gly Glu Ser Ala Leu Ala Gly Ile Tyr Tyr Ser Leu 
145                 150                 155                 160 

Glu Ala Asn Gly Ala Lys Val Pro Gln Ala Asn Lys Asp Leu Ala Gln 
                165                 170                 175     

Glu Glu Leu Lys Ala Leu Ser Asp Ile Asn Ala Glu Asn Lys Asp Lys 
            180                 185                 190         

Ser Gly Tyr Asp Ala Asn Lys Leu Asn Val Ala Leu Ala Asp Ile Lys 
        195                 200                 205             

Ser Gly Leu Ala Lys Ala Lys Glu Ser Lys Gly Asn Leu Thr Glu Glu 
    210                 215                 220                 

Asp Ile Arg Lys Ile Val Glu Asp Thr Leu Lys Asn Tyr Lys Leu Asp 
225                 230                 235                 240 

Gln Val Ile Thr Gly Asn Gln Ile Asn Ile Ile Ile Asn Phe Ala Leu 
                245                 250                 255     

Asn Leu Ser Lys Ser Asp Ile Leu Ser Asn Ala Asp Phe Thr Lys Thr 
            260                 265                 270         

Leu Asn Asp Leu Lys Gln Ser Ile Val Ser Gln Ala Gly Asp Ser Phe 
        275                 280                 285             

Lys Asn Ile Asn Leu Asn Phe Asp Ser Asp Lys Ala Leu Glu Asp Gly 
    290                 295                 300                 

Gly Asn Phe Leu Ser Ser Leu Trp Gln Ala Leu Val Asn Phe Phe Lys 
305                 310                 315                 320 

Ser Phe Gly Ser 
                

<210>   76
<211>   339
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PiaA

<400>   76
Met His Ala Lys Met Arg Asn Lys Lys Gln Ile Asn Leu Gly Ile Ile 
1               5                   10                  15      

Phe Val Ile Cys Leu Gly Leu Leu Ile Thr Ile Phe Leu Ser Leu Lys 
            20                  25                  30          

Leu Gly Thr Lys Glu Ile Asn Ile Arg Asp Phe Leu Ala Ala Phe Gly 
        35                  40                  45              

Met Gly Asn Thr Asn Asp Asp Phe Ile Lys Ser Ile Ile Tyr Lys Arg 
    50                  55                  60                  

Ile Pro Arg Thr Ile Phe Ala Ile Leu Ala Gly Ser Ser Leu Ala Ile 
65                  70                  75                  80  

Ser Gly Val Leu Met Gln Ser Val Thr Arg Asn Pro Ile Ala Asp Pro 
                85                  90                  95      

Gly Ile Leu Gly Ile Asn Thr Gly Ala Ser Leu Ser Val Val Ile Gly 
            100                 105                 110         

Leu Ser Phe Leu Gly Ile Ser Ser Ser Ile Ser His Ile Ser Phe Ala 
        115                 120                 125             

Ile Ile Gly Gly Leu Val Ser Ala Ile Phe Val Tyr Ala Ile Ala Val 
    130                 135                 140                 

Ser Gly Lys Ala Gly Leu Thr Pro Ile Lys Leu Ala Leu Ser Gly Thr 
145                 150                 155                 160 

Cys Val Ser Met Ala Leu Ser Ser Phe Val Ser Phe Leu Ile Leu Pro 
                165                 170                 175     

Asn Asn Asn Val Leu Asp Lys Phe Arg Phe Trp Gln Ile Gly Ser Leu 
            180                 185                 190         

Gly Ala Ala Thr Leu Ser Ser Ile Ser Thr Leu Leu Pro Phe Ile Ile 
        195                 200                 205             

Leu Gly His Leu Ile Ala Ile Phe Ile Ser Ser Asp Leu Asn Ala Leu 
    210                 215                 220                 

Ala Met Gly Asp Glu Met Ala Val Gly Leu Gly Val Asn Val Asn Arg 
225                 230                 235                 240 

Ile Arg Ser Leu Ala Ile Ile Ala Ser Val Leu Leu Cys Ser Ser Ile 
                245                 250                 255     

Thr Ala Ile Gly Gly Pro Ile Gly Phe Val Gly Leu Ile Val Pro His 
            260                 265                 270         

Phe Cys Gly Leu Phe Ile Ser Lys Asp Ile Arg Thr Met Thr Ile Ser 
        275                 280                 285             

Ser Ala Phe Ile Gly Ala Glu Leu Leu Leu Ile Cys Asp Ile Ile Gly 
    290                 295                 300                 

Arg Met Leu Gly Lys Pro Gly Glu Ile Glu Val Gly Ile Ile Thr Ala 
305                 310                 315                 320 

Ile Ile Gly Gly Pro Val Leu Ile Tyr Val Thr Met Lys Asn Arg Gly 
                325                 330                 335     

Val Asn Thr 
            

<210>   77
<211>   321
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PiuA

<400>   77
Met Lys Thr Ser Leu Lys Leu Tyr Phe Thr Ala Leu Val Ala Ser Phe 
1               5                   10                  15      

Leu Leu Leu Leu Gly Ala Cys Ser Thr Asn Ser Ser Thr Ser Gln Thr 
            20                  25                  30          

Glu Thr Ser Ser Ser Ala Pro Thr Glu Ile Thr Ile Lys Ser Ser Leu 
        35                  40                  45              

Asp Glu Val Lys Leu Ser Lys Val Pro Glu Lys Ile Val Thr Phe Asp 
    50                  55                  60                  

Leu Gly Ala Ala Asp Thr Ile Arg Ala Leu Gly Phe Glu Lys Asn Ile 
65                  70                  75                  80  

Val Gly Met Pro Thr Lys Thr Val Pro Thr Tyr Leu Lys Asp Leu Val 
                85                  90                  95      

Gly Thr Val Lys Asn Val Gly Ser Met Lys Glu Pro Asp Leu Glu Ala 
            100                 105                 110         

Ile Ala Ala Leu Glu Pro Asp Leu Ile Ile Ala Ser Pro Arg Thr Gln 
        115                 120                 125             

Lys Phe Val Asp Lys Phe Lys Glu Ile Ala Pro Thr Val Leu Phe Gln 
    130                 135                 140                 

Ala Ser Lys Asp Asp Tyr Trp Thr Ser Thr Lys Ala Asn Ile Glu Ser 
145                 150                 155                 160 

Leu Ala Ser Ala Phe Gly Glu Thr Ser Thr Gln Lys Ala Lys Glu Glu 
                165                 170                 175     

Leu Ala Lys Leu Asp Lys Ser Ile Gln Glu Val Ala Thr Lys Asn Glu 
            180                 185                 190         

Ser Ser Asp Lys Lys Ala Leu Ala Ile Leu Leu Asn Glu Gly Lys Met 
        195                 200                 205             

Ala Ala Phe Gly Ala Lys Ser Arg Phe Ser Phe Leu Tyr Gln Thr Leu 
    210                 215                 220                 

Lys Phe Lys Pro Thr Asp Thr Lys Phe Glu Asp Ser Arg His Gly Gln 
225                 230                 235                 240 

Glu Val Ser Phe Glu Ser Val Lys Glu Ile Asn Pro Asp Ile Leu Phe 
                245                 250                 255     

Val Ile Asn Arg Thr Leu Ala Ile Gly Gly Asp Asn Ser Ser Asn Asp 
            260                 265                 270         

Gly Val Leu Glu Asn Ala Leu Ile Ala Glu Thr Pro Ala Ala Lys Asn 
        275                 280                 285             

Gly Lys Ile Ile Gln Leu Thr Pro Asp Leu Trp Tyr Leu Ser Gly Gly 
    290                 295                 300                 

Gly Leu Glu Ser Thr Lys Leu Met Ile Glu Asp Ile Gln Lys Ala Leu 
305                 310                 315                 320 

Lys 
    

<210>   78
<211>   279
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length CbiO

<400>   78
Met Gly Ile Ala Leu Glu Asn Val Asn Phe Ile Tyr Gln Glu Gly Thr 
1               5                   10                  15      

Pro Leu Ala Ser Ala Ala Leu Ser Asp Val Ser Leu Thr Ile Glu Asp 
            20                  25                  30          

Gly Ser Tyr Thr Ala Leu Ile Gly His Thr Gly Ser Gly Lys Ser Thr 
        35                  40                  45              

Ile Leu Gln Leu Leu Asn Gly Leu Leu Val Pro Ser Gln Gly Ser Val 
    50                  55                  60                  

Arg Val Phe Asp Thr Leu Ile Thr Ser Thr Ser Lys Asn Lys Asp Ile 
65                  70                  75                  80  

Arg Gln Ile Arg Lys Gln Val Gly Leu Val Phe Gln Phe Ala Glu Asn 
                85                  90                  95      

Gln Ile Phe Glu Glu Thr Val Leu Lys Asp Val Ala Phe Gly Pro Gln 
            100                 105                 110         

Asn Phe Gly Val Ser Glu Glu Asp Ala Val Lys Thr Ala Arg Glu Lys 
        115                 120                 125             

Leu Ala Leu Val Gly Ile Asp Glu Ser Leu Phe Asp Arg Ser Pro Phe 
    130                 135                 140                 

Glu Leu Ser Gly Gly Gln Met Arg Arg Val Ala Ile Ala Gly Ile Leu 
145                 150                 155                 160 

Ala Met Glu Pro Ser Ile Leu Val Leu Asp Glu Pro Thr Ala Gly Leu 
                165                 170                 175     

Asp Pro Leu Gly Arg Lys Glu Leu Met Thr Leu Phe Lys Lys Leu His 
            180                 185                 190         

Gln Ser Gly Met Thr Ile Val Leu Val Thr His Leu Met Asp Asp Val 
        195                 200                 205             

Ala Glu Tyr Ala Asn Gln Val Tyr Val Met Glu Lys Gly Arg Leu Val 
    210                 215                 220                 

Lys Gly Gly Lys Pro Ser Asp Val Phe Gln Asp Val Val Phe Met Glu 
225                 230                 235                 240 

Glu Val Gln Leu Gly Val Pro Lys Ile Thr Ala Phe Cys Lys Arg Leu 
                245                 250                 255     

Ala Asp Arg Gly Val Ser Phe Lys Arg Leu Pro Ile Lys Ile Glu Glu 
            260                 265                 270         

Phe Lys Glu Ser Leu Asn Gly 
        275                 

<210>   79
<211>   132
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   30S ribosomal protein S8

<400>   79
Met Val Met Thr Asp Pro Ile Ala Asp Phe Leu Thr Arg Ile Arg Asn 
1               5                   10                  15      

Ala Asn Gln Ala Lys His Glu Val Leu Glu Val Pro Ala Ser Asn Ile 
            20                  25                  30          

Lys Lys Gly Ile Ala Glu Ile Leu Lys Arg Glu Gly Phe Val Lys Asn 
        35                  40                  45              

Val Glu Ile Ile Glu Asp Asp Lys Gln Gly Val Ile Arg Val Phe Leu 
    50                  55                  60                  

Lys Tyr Gly Pro Asn Gly Glu Lys Val Ile Thr Asn Leu Lys Arg Val 
65                  70                  75                  80  

Ser Lys Pro Gly Leu Arg Val Tyr Lys Lys Arg Glu Asp Leu Pro Lys 
                85                  90                  95      

Val Leu Asn Gly Leu Gly Ile Ala Ile Leu Ser Thr Ser Glu Gly Leu 
            100                 105                 110         

Leu Thr Asp Lys Glu Ala Arg Gln Lys Asn Val Gly Gly Glu Val Ile 
        115                 120                 125             

Ala Tyr Val Trp 
    130         

<210>   80
<211>   26
<212>   DNA
<213>   Artificial

<220>
<223>   deoxynucleotide comprising 26-mer sequence 5'-(IC)13-3'

<220>
<221>   misc_feature
<222>   (1), (3), (5), (7), (9), (11), (13), (15), (17), (19), (21), (23), (25)
<223>   n = inosine

<400>   80
ncncncncnc ncncncncnc ncncnc                                        26

<210>   81
<211>   11
<212>   PRT
<213>   Artificial

<220>
<223>   polycationic peptide comprising 11-mer amino acid sequence

<400>   81
Lys Leu Lys Leu Leu Leu Leu Leu Lys Leu Lys 
1               5                   10      

<210>   82
<211>   1427
<212>   PRT
<213>   Artificial

<220>
<223>   hybrid protein; spr0057 and spr0096

<400>   82
Met Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr Ile 
1               5                   10                  15      

His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu Glu 
            20                  25                  30          

Thr Pro Lys Ala Val Leu Gln Pro Glu Ala Pro Lys Thr Val Glu Thr 
        35                  40                  45              

Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu Glu 
    50                  55                  60                  

Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu Val 
65                  70                  75                  80  

Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Ala Glu 
                85                  90                  95      

Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys Glu 
            100                 105                 110         

Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp Glu 
        115                 120                 125             

Ala Lys Ala Glu Ala Asp Lys Pro Ala Thr Glu Ala Gly Lys Glu Arg 
    130                 135                 140                 

Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser Ile 
145                 150                 155                 160 

Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile Ile 
                165                 170                 175     

Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val Gly 
            180                 185                 190         

Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala Asn 
        195                 200                 205             

Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys Gly 
    210                 215                 220                 

Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu Ser 
225                 230                 235                 240 

Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly Leu 
                245                 250                 255     

Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn Ala 
            260                 265                 270         

Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly Lys 
        275                 280                 285             

Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala Phe 
    290                 295                 300                 

Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys Thr 
305                 310                 315                 320 

Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr Asp 
                325                 330                 335     

Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn Glu 
            340                 345                 350         

Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn Asp 
        355                 360                 365             

Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe Asn 
    370                 375                 380                 

Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp Lys 
385                 390                 395                 400 

Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp Val 
                405                 410                 415     

Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn Thr 
            420                 425                 430         

Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln Gly 
        435                 440                 445             

Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro Ile 
    450                 455                 460                 

Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly Gly 
465                 470                 475                 480 

Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro Ser 
                485                 490                 495     

Arg Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu Tyr 
            500                 505                 510         

Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val Pro 
        515                 520                 525             

Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Thr Ala Val Lys Glu 
    530                 535                 540                 

Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala Gln 
545                 550                 555                 560 

Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val Asn 
                565                 570                 575     

Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys Arg 
            580                 585                 590         

Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala Gly 
        595                 600                 605             

Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys Arg Ile Val Asp Lys Ala 
    610                 615                 620                 

Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp Gly 
625                 630                 635                 640 

Leu Arg Phe Leu Leu Asp Asp Met Thr Ile Thr Ala Asn Gly Lys Thr 
                645                 650                 655     

Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys Ala 
            660                 665                 670         

Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val Thr 
        675                 680                 685             

Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro Ala 
    690                 695                 700                 

Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu Lys 
705                 710                 715                 720 

Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys Thr 
                725                 730                 735     

Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala Leu 
            740                 745                 750         

Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe Asn 
        755                 760                 765             

Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly Trp 
    770                 775                 780                 

Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr Ala 
785                 790                 795                 800 

Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met Ala 
                805                 810                 815     

Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe Asp 
            820                 825                 830         

Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr Asn 
        835                 840                 845             

Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu Asn 
    850                 855                 860                 

Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly Gln Lys Pro Glu Asp Gly 
865                 870                 875                 880 

Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn Thr Gly Lys Thr Pro Phe 
                885                 890                 895     

Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr Val 
            900                 905                 910         

Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr Lys 
        915                 920                 925             

Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn Lys 
    930                 935                 940                 

Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala Lys 
945                 950                 955                 960 

Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala Leu 
                965                 970                 975     

Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys Gln 
            980                 985                 990         

Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln Gly 
        995                 1000                1005            

Leu Lys Pro Ala Val Thr His Ser Gly Ser Leu Asp Glu Asn Glu Val 
    1010                1015                1020                

Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu Glu 
1025                1030                1035                1040

Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala Gly 
                1045                1050                1055    

Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His Tyr 
            1060                1065                1070        

Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu Asp 
        1075                1080                1085            

Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly Ala 
    1090                1095                1100                

Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr Glu 
1105                1110                1115                1120

Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr Thr 
                1125                1130                1135    

Val Thr Cys Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val Ile 
            1140                1145                1150        

Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser Thr 
        1155                1160                1165            

Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val Ala 
    1170                1175                1180                

Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr His 
1185                1190                1195                1200

Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro Lys 
                1205                1210                1215    

Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu Glu 
            1220                1225                1230        

Ser Lys Val Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys Lys 
        1235                1240                1245            

Gly Ser Gly Ser Gly Gly Gly Gly Val Ser Ala Gln Glu Ser Ser Thr 
    1250                1255                1260                

Tyr Thr Val Lys Glu Gly Asp Thr Leu Ser Glu Ile Ala Glu Thr His 
1265                1270                1275                1280

Asn Thr Thr Val Glu Lys Leu Ala Glu Asn Asn His Ile Asp Asn Ile 
                1285                1290                1295    

His Leu Ile Tyr Val Asp Gln Glu Leu Val Ile Asp Gly Pro Val Ala 
            1300                1305                1310        

Pro Val Ala Thr Pro Ala Pro Ala Thr Tyr Ala Ala Pro Ala Ala Gln 
        1315                1320                1325            

Asp Glu Thr Val Ser Ala Pro Val Ala Glu Thr Pro Val Val Ser Glu 
    1330                1335                1340                

Thr Val Val Ser Thr Val Ser Gly Ser Glu Ala Glu Ala Lys Glu Trp 
1345                1350                1355                1360

Ile Ala Gln Lys Glu Ser Gly Gly Ser Tyr Thr Ala Thr Asn Gly Arg 
                1365                1370                1375    

Tyr Ile Gly Arg Tyr Gln Leu Thr Asp Ser Tyr Leu Asn Gly Asp Tyr 
            1380                1385                1390        

Ser Ala Glu Asn Gln Glu Arg Val Ala Asp Ala Tyr Val Ala Gly Arg 
        1395                1400                1405            

Tyr Gly Ser Trp Thr Ala Ala Lys Asn Phe Trp Leu Asn Asn Gly Trp 
    1410                1415                1420                

Tyr Leu Glu 
1425        

<210>   83
<211>   1242
<212>   PRT
<213>   Artificial

<220>
<223>   hybrid protein; spr0057 and spr0096

<400>   83
Met Leu His Leu Leu Val Gly Asn Asp Gly Leu Arg Phe Met Leu Asp 
1               5                   10                  15      

Asp Met Ser Ile Thr Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val 
            20                  25                  30          

Lys Arg Ala Ile Glu Lys Gly Thr Asn Asp Tyr Tyr Asn Asp Pro Asn 
        35                  40                  45              

Gly Asn His Leu Thr Glu Ser Gln Met Thr Asp Leu Ile Asn Tyr Ala 
    50                  55                  60                  

Lys Asp Lys Gly Ile Gly Leu Ile Pro Thr Val Asn Ser Pro Gly His 
65                  70                  75                  80  

Met Asp Ala Ile Leu Asn Ala Met Lys Glu Leu Gly Ile Gln Asn Pro 
                85                  90                  95      

Asn Phe Ser Tyr Phe Gly Lys Lys Ser Ala Arg Thr Val Asp Leu Asp 
            100                 105                 110         

Asn Glu Gln Ala Val Ala Phe Thr Lys Ala Leu Ile Asp Lys Tyr Ala 
        115                 120                 125             

Ala Tyr Phe Ala Lys Lys Thr Glu Ile Phe Asn Ile Gly Leu Asp Glu 
    130                 135                 140                 

Tyr Ala Asn Asp Ala Thr Asp Ala Lys Gly Trp Ser Val Leu Gln Ala 
145                 150                 155                 160 

Asp Lys Tyr Tyr Pro Asn Glu Gly Tyr Pro Val Lys Gly Tyr Glu Lys 
                165                 170                 175     

Phe Ile Ala Tyr Ala Asn Asp Leu Ala Arg Ile Val Lys Ser His Gly 
            180                 185                 190         

Leu Lys Pro Met Ala Phe Asn Asp Gly Ile Tyr Tyr Asn Ser Asp Thr 
        195                 200                 205             

Ser Phe Gly Ser Phe Asp Lys Asp Ile Ile Val Ser Met Trp Thr Gly 
    210                 215                 220                 

Gly Trp Gly Gly Tyr Asp Val Ala Ser Ser Lys Leu Leu Ala Glu Lys 
225                 230                 235                 240 

Gly His Gln Ile Leu Asn Thr Asn Asp Ala Trp Tyr Tyr Val Leu Gly 
                245                 250                 255     

Arg Asn Ala Asp Gly Gln Gly Trp Tyr Asn Leu Asp Gln Gly Leu Asn 
            260                 265                 270         

Gly Ile Lys Asn Thr Pro Ile Thr Ser Val Pro Lys Thr Glu Gly Ala 
        275                 280                 285             

Asp Ile Pro Ile Ile Gly Gly Met Val Ala Ala Trp Ala Asp Thr Pro 
    290                 295                 300                 

Ser Ala Arg Tyr Ser Pro Ser Arg Leu Phe Lys Leu Met Arg His Phe 
305                 310                 315                 320 

Ala Asn Ala Asn Ala Glu Tyr Phe Ala Ala Asp Tyr Glu Ser Ala Glu 
                325                 330                 335     

Gln Ala Leu Asn Glu Val Pro Lys Asp Leu Asn Arg Tyr Thr Ala Glu 
            340                 345                 350         

Ser Val Thr Ala Val Lys Glu Ala Glu Lys Ala Ile Arg Ser Leu Asp 
        355                 360                 365             

Ser Asn Leu Ser Arg Ala Gln Gln Asp Thr Ile Asp Gln Ala Ile Ala 
    370                 375                 380                 

Lys Leu Gln Glu Thr Val Asn Asn Leu Thr Leu Thr Pro Glu Ala Gln 
385                 390                 395                 400 

Lys Glu Glu Glu Ala Lys Arg Glu Val Glu Lys Leu Ala Lys Asn Lys 
                405                 410                 415     

Val Ile Ser Ile Asp Ala Gly Arg Lys Tyr Phe Thr Leu Asn Gln Leu 
            420                 425                 430         

Lys Arg Ile Val Asp Lys Ala Ser Glu Leu Gly Tyr Ser Asp Val His 
        435                 440                 445             

Leu Leu Leu Gly Asn Asp Gly Leu Arg Phe Leu Leu Asp Asp Met Thr 
    450                 455                 460                 

Ile Thr Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Lys Ala 
465                 470                 475                 480 

Ile Ile Glu Gly Thr Lys Ala Tyr Tyr Asp Asp Pro Asn Gly Thr Ala 
                485                 490                 495     

Leu Thr Gln Ala Glu Val Thr Glu Leu Ile Glu Tyr Ala Lys Ser Lys 
            500                 505                 510         

Asp Ile Gly Leu Ile Pro Ala Ile Asn Ser Pro Gly His Met Asp Ala 
        515                 520                 525             

Met Leu Val Ala Met Glu Lys Leu Gly Ile Lys Asn Pro Gln Ala His 
    530                 535                 540                 

Phe Asp Lys Val Ser Lys Thr Thr Met Asp Leu Lys Asn Glu Glu Ala 
545                 550                 555                 560 

Met Asn Phe Val Lys Ala Leu Ile Gly Lys Tyr Met Asp Phe Phe Ala 
                565                 570                 575     

Gly Lys Thr Lys Ile Phe Asn Phe Gly Thr Asp Glu Tyr Ala Asn Asp 
            580                 585                 590         

Ala Thr Ser Ala Gln Gly Trp Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr 
        595                 600                 605             

Gly Lys Phe Ala Glu Tyr Ala Asn Thr Leu Ala Ala Met Ala Lys Glu 
    610                 615                 620                 

Arg Gly Leu Gln Pro Met Ala Phe Asn Asp Gly Phe Tyr Tyr Glu Asp 
625                 630                 635                 640 

Lys Asp Asp Val Gln Phe Asp Lys Asp Val Leu Ile Ser Tyr Trp Ser 
                645                 650                 655     

Lys Gly Trp Trp Gly Tyr Asn Leu Ala Ser Pro Gln Tyr Leu Ala Ser 
            660                 665                 670         

Lys Gly Tyr Lys Phe Leu Asn Thr Asn Gly Asp Trp Tyr Tyr Ile Leu 
        675                 680                 685             

Gly Gln Lys Pro Glu Asp Gly Gly Gly Phe Leu Lys Lys Ala Ile Glu 
    690                 695                 700                 

Asn Thr Gly Lys Thr Pro Phe Asn Gln Leu Ala Ser Thr Lys Tyr Pro 
705                 710                 715                 720 

Glu Val Asp Leu Pro Thr Val Gly Ser Met Leu Ser Ile Trp Ala Asp 
                725                 730                 735     

Arg Pro Ser Ala Glu Tyr Lys Glu Glu Glu Ile Phe Glu Leu Met Thr 
            740                 745                 750         

Ala Phe Ala Asp His Asn Lys Asp Tyr Phe Arg Ala Asn Tyr Asn Ala 
        755                 760                 765             

Leu Arg Glu Glu Leu Ala Lys Ile Pro Thr Asn Leu Glu Gly Tyr Ser 
    770                 775                 780                 

Lys Glu Ser Leu Glu Ala Leu Asp Ala Ala Lys Thr Ala Leu Asn Tyr 
785                 790                 795                 800 

Asn Leu Asn Arg Asn Lys Gln Ala Glu Leu Asp Thr Leu Val Ala Asn 
                805                 810                 815     

Leu Lys Ala Ala Leu Gln Gly Leu Lys Pro Ala Val Thr His Ser Gly 
            820                 825                 830         

Ser Leu Asp Glu Asn Glu Val Ala Ala Asn Val Glu Thr Arg Pro Glu 
        835                 840                 845             

Leu Ile Thr Arg Thr Glu Glu Ile Pro Phe Glu Val Ile Lys Lys Glu 
    850                 855                 860                 

Asn Pro Asn Leu Pro Ala Gly Gln Glu Asn Ile Ile Thr Ala Gly Val 
865                 870                 875                 880 

Lys Gly Glu Arg Thr His Tyr Ile Ser Val Leu Thr Glu Asn Gly Lys 
                885                 890                 895     

Thr Thr Glu Thr Val Leu Asp Ser Gln Val Thr Lys Glu Val Ile Asn 
            900                 905                 910         

Gln Val Val Glu Val Gly Ala Pro Val Thr His Lys Gly Asp Glu Ser 
        915                 920                 925             

Gly Leu Ala Pro Thr Thr Glu Val Lys Pro Arg Leu Asp Ile Gln Glu 
    930                 935                 940                 

Glu Glu Ile Pro Phe Thr Thr Val Thr Cys Glu Asn Pro Leu Leu Leu 
945                 950                 955                 960 

Lys Gly Lys Thr Gln Val Ile Thr Lys Gly Val Asn Gly His Arg Ser 
                965                 970                 975     

Asn Phe Tyr Ser Val Ser Thr Ser Ala Asp Gly Lys Glu Val Lys Thr 
            980                 985                 990         

Leu Val Asn Ser Val Val Ala Gln Glu Ala Val Thr Gln Ile Val Glu 
        995                 1000                1005            

Val Gly Thr Met Val Thr His Val Gly Asp Glu Asn Gly Gln Ala Ala 
    1010                1015                1020                

Ile Ala Glu Glu Lys Pro Lys Leu Glu Ile Pro Ser Gln Pro Ala Pro 
1025                1030                1035                1040

Ser Thr Ala Pro Ala Glu Glu Ser Lys Val Leu Pro Gln Asp Pro Ala 
                1045                1050                1055    

Pro Val Val Thr Glu Lys Lys Gly Ser Gly Ser Gly Gly Gly Gly Val 
            1060                1065                1070        

Ser Ala Gln Glu Ser Ser Thr Tyr Thr Val Lys Glu Gly Asp Thr Leu 
        1075                1080                1085            

Ser Glu Ile Ala Glu Thr His Asn Thr Thr Val Glu Lys Leu Ala Glu 
    1090                1095                1100                

Asn Asn His Ile Asp Asn Ile His Leu Ile Tyr Val Asp Gln Glu Leu 
1105                1110                1115                1120

Val Ile Asp Gly Pro Val Ala Pro Val Ala Thr Pro Ala Pro Ala Thr 
                1125                1130                1135    

Tyr Ala Ala Pro Ala Ala Gln Asp Glu Thr Val Ser Ala Pro Val Ala 
            1140                1145                1150        

Glu Thr Pro Val Val Ser Glu Thr Val Val Ser Thr Val Ser Gly Ser 
        1155                1160                1165            

Glu Ala Glu Ala Lys Glu Trp Ile Ala Gln Lys Glu Ser Gly Gly Ser 
    1170                1175                1180                

Tyr Thr Ala Thr Asn Gly Arg Tyr Ile Gly Arg Tyr Gln Leu Thr Asp 
1185                1190                1195                1200

Ser Tyr Leu Asn Gly Asp Tyr Ser Ala Glu Asn Gln Glu Arg Val Ala 
                1205                1210                1215    

Asp Ala Tyr Val Ala Gly Arg Tyr Gly Ser Trp Thr Ala Ala Lys Asn 
            1220                1225                1230        

Phe Trp Leu Asn Asn Gly Trp Tyr Leu Glu 
        1235                1240        

<210>   84
<211>   549
<212>   PRT
<213>   Artificial

<220>
<223>   hybrid protein; spr0096 and spr2021

<400>   84
Met Val Ser Ala Gln Glu Ser Ser Thr Tyr Thr Val Lys Glu Gly Asp 
1               5                   10                  15      

Thr Leu Ser Glu Ile Ala Glu Thr His Asn Thr Thr Val Glu Lys Leu 
            20                  25                  30          

Ala Glu Asn Asn His Ile Asp Asn Ile His Leu Ile Tyr Val Asp Gln 
        35                  40                  45              

Glu Leu Val Ile Asp Gly Pro Val Ala Pro Val Ala Thr Pro Ala Pro 
    50                  55                  60                  

Ala Thr Tyr Ala Ala Pro Ala Ala Gln Asp Glu Thr Val Ser Ala Pro 
65                  70                  75                  80  

Val Ala Glu Thr Pro Val Val Ser Glu Thr Val Val Ser Thr Val Ser 
                85                  90                  95      

Gly Ser Glu Ala Glu Ala Lys Glu Trp Ile Ala Gln Lys Glu Ser Gly 
            100                 105                 110         

Gly Ser Tyr Thr Ala Thr Asn Gly Arg Tyr Ile Gly Arg Tyr Gln Leu 
        115                 120                 125             

Thr Asp Ser Tyr Leu Asn Gly Asp Tyr Ser Ala Glu Asn Gln Glu Arg 
    130                 135                 140                 

Val Ala Asp Ala Tyr Val Ala Gly Arg Tyr Gly Ser Trp Thr Ala Ala 
145                 150                 155                 160 

Lys Asn Phe Trp Leu Asn Asn Gly Trp Tyr Gly Ser Gly Ser Gly Gly 
                165                 170                 175     

Gly Gly Ala Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp Asn Lys 
            180                 185                 190         

Ile Ser Asn Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln Val Asp 
        195                 200                 205             

Gln Ile Gln Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser Asn Leu 
    210                 215                 220                 

Gln Ala Glu Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu Glu Gly 
225                 230                 235                 240 

Glu Ile Thr Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln Ser Leu 
                245                 250                 255     

Glu Lys Gln Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr Ser Tyr 
            260                 265                 270         

Ile Asn Thr Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile Ser Arg 
        275                 280                 285             

Val Ala Ala Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met Leu Glu 
    290                 295                 300                 

Gln Gln Lys Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val Ala Asn 
305                 310                 315                 320 

Asn Asp Ala Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu Ala Asp 
                325                 330                 335     

Asp Ala Gln Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala Ala Glu 
            340                 345                 350         

Leu Ser Leu Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys Ala Ser 
        355                 360                 365             

Leu Leu Glu Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala Ala Ala 
    370                 375                 380                 

Val Ala Glu Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln Gln Ser 
385                 390                 395                 400 

Val Leu Ala Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln Ala Val 
                405                 410                 415     

Ser Glu Ser Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro Thr Tyr 
            420                 425                 430         

Ser Thr Asn Ala Ser Ser Tyr Pro Ile Gly Glu Cys Thr Trp Gly Val 
        435                 440                 445             

Lys Thr Leu Ala Pro Trp Ala Gly Asp Tyr Trp Gly Asn Gly Ala Gln 
    450                 455                 460                 

Trp Ala Thr Ser Ala Ala Ala Ala Gly Phe Arg Thr Gly Ser Thr Pro 
465                 470                 475                 480 

Gln Val Gly Ala Ile Ala Cys Trp Asn Asp Gly Gly Tyr Gly His Val 
                485                 490                 495     

Ala Val Val Thr Ala Val Glu Ser Thr Thr Arg Ile Gln Val Ser Glu 
            500                 505                 510         

Ser Asn Tyr Ala Gly Asn Arg Thr Ile Gly Asn His Arg Gly Trp Phe 
        515                 520                 525             

Asn Pro Thr Thr Thr Ser Glu Gly Phe Val Thr Tyr Ile Tyr Ala Asp 
    530                 535                 540                 

Ala Ala Ala Leu Glu 
545                 

<210>   85
<211>   665
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   85
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Gly Thr 
            20                  25                  30          

Thr Thr Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp 
        35                  40                  45              

Met Asp Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn 
    50                  55                  60                  

Lys Val Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met 
65                  70                  75                  80  

Phe Val Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln 
                85                  90                  95      

Thr Leu Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala 
            100                 105                 110         

Met Pro Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys 
        115                 120                 125             

Phe Asn Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile 
    130                 135                 140                 

His Ser Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly 
145                 150                 155                 160 

Ser Lys Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val 
                165                 170                 175     

Asp Ala His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp 
            180                 185                 190         

Lys Asp Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys 
        195                 200                 205             

Asp Thr Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile 
    210                 215                 220                 

Val Thr Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser 
225                 230                 235                 240 

Asp Arg Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val 
                245                 250                 255     

Thr Val Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu 
            260                 265                 270         

Val Ala Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys 
        275                 280                 285             

Val Asn Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala 
    290                 295                 300                 

Thr Leu Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val 
305                 310                 315                 320 

Thr Phe Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro 
                325                 330                 335     

Asn Lys Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val 
            340                 345                 350         

Asp Ala Thr Gly Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp 
        355                 360                 365             

Leu Val Asn Ala Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr 
    370                 375                 380                 

Thr Asp Lys Asn Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu 
385                 390                 395                 400 

Tyr Lys Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln 
                405                 410                 415     

Glu Ile Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu 
            420                 425                 430         

Asn Pro Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly 
        435                 440                 445             

Lys Lys Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala 
    450                 455                 460                 

Glu Phe Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg 
465                 470                 475                 480 

Lys Ala Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr 
                485                 490                 495     

Lys Asp Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala 
            500                 505                 510         

Gln Gln Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala 
        515                 520                 525             

Ala Tyr Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val 
    530                 535                 540                 

Ala Asp Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln 
545                 550                 555                 560 

Gly Arg Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu 
                565                 570                 575     

Glu Thr Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys 
            580                 585                 590         

Phe Glu Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu 
        595                 600                 605             

Tyr Thr Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys 
    610                 615                 620                 

Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala 
625                 630                 635                 640 

Val Ala Gly Ala Val Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys 
                645                 650                 655     

Asn Asn Lys Asp Glu Asp Gln Leu Ala 
            660                 665 

<210>   86
<211>   644
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   86
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Asp Asn 
            20                  25                  30          

Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys 
        35                  40                  45              

Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro 
    50                  55                  60                  

Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val 
65                  70                  75                  80  

Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn 
                85                  90                  95      

Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp 
            100                 105                 110         

Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu 
        115                 120                 125             

Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys 
    130                 135                 140                 

Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala 
145                 150                 155                 160 

Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val 
                165                 170                 175     

Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val 
            180                 185                 190         

Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu 
        195                 200                 205             

Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser 
    210                 215                 220                 

Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly 
225                 230                 235                 240 

Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met 
                245                 250                 255     

Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Ile Asn Gly Phe Asn Leu 
            260                 265                 270         

Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp 
        275                 280                 285             

Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val 
    290                 295                 300                 

Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His 
305                 310                 315                 320 

Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln 
                325                 330                 335     

Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val 
            340                 345                 350         

Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly 
        355                 360                 365             

Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly 
    370                 375                 380                 

Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr 
385                 390                 395                 400 

Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn 
                405                 410                 415     

Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val 
            420                 425                 430         

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg 
        435                 440                 445             

Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr 
    450                 455                 460                 

Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala 
465                 470                 475                 480 

Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn 
                485                 490                 495     

Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln 
            500                 505                 510         

Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val 
        515                 520                 525             

Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln 
    530                 535                 540                 

Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile 
545                 550                 555                 560 

Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val 
                565                 570                 575     

Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val 
            580                 585                 590         

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Ile Pro 
        595                 600                 605             

Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala Val Ala Gly Ala Ala 
    610                 615                 620                 

Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu 
625                 630                 635                 640 

Asp Gln Leu Ala 
                

<210>   87
<211>   654
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   87
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Glu Gln 
            20                  25                  30          

Lys Thr Lys Thr Leu Thr Val His Lys Leu Leu Met Thr Asp Gln Glu 
        35                  40                  45              

Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr Thr Ala Gly Tyr Asp Gly 
    50                  55                  60                  

Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu Gln Gly Val Pro Gln Gly 
65                  70                  75                  80  

Val Thr Glu Ile Ser Gly Val Ala Phe Glu Leu Gln Ser Tyr Thr Gly 
                85                  90                  95      

Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr Asn Asp Ala Val Trp Thr 
            100                 105                 110         

Ala Val Asn Lys Gly Val Thr Thr Glu Thr Gly Val Lys Phe Asp Thr 
        115                 120                 125             

Glu Val Leu Gln Gly Thr Tyr Arg Leu Val Glu Val Arg Lys Glu Ser 
    130                 135                 140                 

Thr Tyr Val Gly Pro Asn Gly Lys Val Leu Thr Gly Met Lys Ala Val 
145                 150                 155                 160 

Pro Ala Leu Ile Ile Leu Pro Leu Val Asn Gln Asn Gly Val Val Glu 
                165                 170                 175     

Asn Ala His Val Tyr Pro Lys Asn Ser Glu Asp Lys Pro Thr Ala Thr 
            180                 185                 190         

Lys Thr Phe Asp Thr Ala Ala Gly Phe Val Asp Pro Gly Glu Lys Gly 
        195                 200                 205             

Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile Val Thr Thr Thr Ile Pro 
    210                 215                 220                 

Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp Ser Asp Glu Met Thr Glu 
225                 230                 235                 240 

Gly Leu Asp Tyr Asn Gly Asp Val Val Val Asn Tyr Asn Gly Gln Pro 
                245                 250                 255     

Leu Asp Asn Ser His Tyr Thr Leu Glu Ala Gly His Asn Gly Phe Ile 
            260                 265                 270         

Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala Ile Asn Gly Lys Asp Ala 
        275                 280                 285             

Glu Ala Thr Ile Thr Leu Lys Tyr Thr Ala Thr Leu Asn Ala Leu Ala 
    290                 295                 300                 

Val Ala Asp Val Pro Glu Ala Asn Asp Val Thr Phe His Tyr Gly Asn 
305                 310                 315                 320 

Asn Pro Gly His Gly Asn Thr Pro Lys Pro Asn Lys Pro Lys Asn Gly 
                325                 330                 335     

Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp Ala Lys Asp Ala Pro Ile 
            340                 345                 350         

Ala Gly Val Glu Val Thr Phe Asp Leu Val Asn Ala Gln Thr Gly Glu 
        355                 360                 365             

Val Val Lys Val Pro Gly His Glu Thr Gly Ile Val Leu Asn Gln Thr 
    370                 375                 380                 

Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu Asp Asn Asn Thr Glu Tyr 
385                 390                 395                 400 

Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Thr 
                405                 410                 415     

Ile Thr Glu Thr Gly Lys Ile Ala Val Lys Asn Trp Lys Asp Glu Asn 
            420                 425                 430         

Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly Lys 
        435                 440                 445             

Lys Phe Val Lys Val Asp Gln Lys Asp Glu Arg Leu Lys Glu Ala Gln 
    450                 455                 460                 

Phe Val Val Lys Asn Glu Gln Gly Lys Tyr Leu Ala Leu Lys Ser Ala 
465                 470                 475                 480 

Ala Gln Gln Ala Val Asn Glu Lys Ala Ala Ala Glu Ala Lys Gln Ala 
                485                 490                 495     

Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala Ala Asp Lys Asn Ala 
            500                 505                 510         

Ala Gln Ala Val Val Asp Ala Ala Gln Lys Thr Tyr Asn Asp Asn Tyr 
        515                 520                 525             

Arg Ala Ala Arg Phe Gly Tyr Val Glu Val Glu Arg Lys Glu Asp Ala 
    530                 535                 540                 

Leu Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser Gly Leu 
545                 550                 555                 560 

Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr Lys Ala Pro Glu Gly Phe 
                565                 570                 575     

Ala Lys Leu Gly Asp Val Lys Phe Glu Val Gly Ala Gly Ser Trp Asn 
            580                 585                 590         

Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp Ala Thr 
        595                 600                 605             

Lys Val Val Asn Lys Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly 
    610                 615                 620                 

Thr Ile Ile Phe Ala Val Ala Gly Ala Val Ile Met Gly Ile Ala Val 
625                 630                 635                 640 

Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu Asp Gln Leu Ala 
                645                 650                 

<210>   88
<211>   665
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   88
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Gly Thr 
            20                  25                  30          

Thr Thr Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp 
        35                  40                  45              

Met Asp Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn 
    50                  55                  60                  

Lys Val Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met 
65                  70                  75                  80  

Phe Val Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln 
                85                  90                  95      

Thr Leu Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala 
            100                 105                 110         

Met Pro Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys 
        115                 120                 125             

Phe Asn Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile 
    130                 135                 140                 

His Ser Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly 
145                 150                 155                 160 

Ser Lys Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val 
                165                 170                 175     

Asp Ala His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp 
            180                 185                 190         

Lys Asp Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys 
        195                 200                 205             

Asp Thr Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile 
    210                 215                 220                 

Val Thr Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser 
225                 230                 235                 240 

Asp Arg Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val 
                245                 250                 255     

Thr Val Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu 
            260                 265                 270         

Val Ala Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys 
        275                 280                 285             

Val Asn Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala 
    290                 295                 300                 

Thr Leu Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val 
305                 310                 315                 320 

Thr Phe Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro 
                325                 330                 335     

Asn Lys Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val 
            340                 345                 350         

Asp Ala Thr Gly Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp 
        355                 360                 365             

Leu Val Asn Ala Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr 
    370                 375                 380                 

Thr Asp Lys Asn Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu 
385                 390                 395                 400 

Tyr Lys Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln 
                405                 410                 415     

Glu Ile Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu 
            420                 425                 430         

Asn Pro Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly 
        435                 440                 445             

Lys Lys Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala 
    450                 455                 460                 

Glu Phe Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg 
465                 470                 475                 480 

Lys Ala Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr 
                485                 490                 495     

Lys Asp Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala 
            500                 505                 510         

Gln Gln Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala 
        515                 520                 525             

Ala Tyr Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val 
    530                 535                 540                 

Ala Asp Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln 
545                 550                 555                 560 

Gly Arg Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu 
                565                 570                 575     

Glu Thr Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys 
            580                 585                 590         

Phe Glu Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu 
        595                 600                 605             

Tyr Thr Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys 
    610                 615                 620                 

Lys Ile Met Ile Pro Gln Pro Gly Gly Ile Gly Thr Ile Ile Phe Ala 
625                 630                 635                 640 

Val Ala Gly Ala Val Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys 
                645                 650                 655     

Asn Asn Lys Asp Glu Asp Gln Leu Ala 
            660                 665 

<210>   89
<211>   665
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   89
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Gly Thr 
            20                  25                  30          

Thr Thr Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp 
        35                  40                  45              

Met Asp Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn 
    50                  55                  60                  

Lys Val Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met 
65                  70                  75                  80  

Phe Val Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln 
                85                  90                  95      

Thr Leu Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala 
            100                 105                 110         

Met Pro Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys 
        115                 120                 125             

Phe Asn Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile 
    130                 135                 140                 

His Ser Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly 
145                 150                 155                 160 

Ser Lys Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val 
                165                 170                 175     

Asp Ala His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp 
            180                 185                 190         

Lys Asp Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys 
        195                 200                 205             

Asp Thr Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile 
    210                 215                 220                 

Val Thr Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser 
225                 230                 235                 240 

Asp Arg Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val 
                245                 250                 255     

Thr Val Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu 
            260                 265                 270         

Val Ala Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys 
        275                 280                 285             

Val Asn Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala 
    290                 295                 300                 

Thr Leu Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val 
305                 310                 315                 320 

Thr Phe Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro 
                325                 330                 335     

Asn Lys Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val 
            340                 345                 350         

Asp Asp Thr Gly Ala Ala Ile Pro Ala Gly Asp Glu Ala Thr Phe Asp 
        355                 360                 365             

Leu Val Asn Ala Gln Thr Gly Lys Val Val Gln Leu Val Thr Ser Ser 
    370                 375                 380                 

Thr Asp Lys Asn Thr Val Thr Val Thr Gly Leu Asp Lys Asn Thr Glu 
385                 390                 395                 400 

Tyr Lys Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln 
                405                 410                 415     

Glu Ile Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu 
            420                 425                 430         

Asn Pro Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly 
        435                 440                 445             

Lys Lys Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala 
    450                 455                 460                 

Glu Phe Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg 
465                 470                 475                 480 

Lys Ala Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr 
                485                 490                 495     

Lys Asp Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala 
            500                 505                 510         

Gln Gln Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala 
        515                 520                 525             

Ala Tyr Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val 
    530                 535                 540                 

Ala Asp Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln 
545                 550                 555                 560 

Gly Arg Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu 
                565                 570                 575     

Glu Thr Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys 
            580                 585                 590         

Phe Glu Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu 
        595                 600                 605             

Tyr Thr Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys 
    610                 615                 620                 

Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala 
625                 630                 635                 640 

Val Ala Gly Ala Val Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys 
                645                 650                 655     

Asn Asn Lys Asp Glu Asp His Leu Ala 
            660                 665 

<210>   90
<211>   644
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   90
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Asp Asn 
            20                  25                  30          

Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys 
        35                  40                  45              

Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro 
    50                  55                  60                  

Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val 
65                  70                  75                  80  

Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn 
                85                  90                  95      

Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp 
            100                 105                 110         

Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu 
        115                 120                 125             

Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys 
    130                 135                 140                 

Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala 
145                 150                 155                 160 

Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val 
                165                 170                 175     

Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val 
            180                 185                 190         

Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu 
        195                 200                 205             

Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser 
    210                 215                 220                 

Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly 
225                 230                 235                 240 

Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met 
                245                 250                 255     

Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Ile Asn Gly Phe Asn Leu 
            260                 265                 270         

Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp 
        275                 280                 285             

Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val 
    290                 295                 300                 

Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His 
305                 310                 315                 320 

Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln 
                325                 330                 335     

Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val 
            340                 345                 350         

Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly 
        355                 360                 365             

Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly 
    370                 375                 380                 

Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr 
385                 390                 395                 400 

Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn 
                405                 410                 415     

Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Leu Glu Glu Pro Arg Val 
            420                 425                 430         

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg 
        435                 440                 445             

Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr 
    450                 455                 460                 

Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala 
465                 470                 475                 480 

Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn 
                485                 490                 495     

Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln 
            500                 505                 510         

Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val 
        515                 520                 525             

Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln 
    530                 535                 540                 

Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile 
545                 550                 555                 560 

Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val 
                565                 570                 575     

Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val 
            580                 585                 590         

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Ile Pro 
        595                 600                 605             

Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala Val Ala Gly Ala Val 
    610                 615                 620                 

Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu 
625                 630                 635                 640 

Asp Gln Leu Ala 
                

<210>   91
<211>   644
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   91
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Asp Asn 
            20                  25                  30          

Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys 
        35                  40                  45              

Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro 
    50                  55                  60                  

Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val 
65                  70                  75                  80  

Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn 
                85                  90                  95      

Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp 
            100                 105                 110         

Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu 
        115                 120                 125             

Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys 
    130                 135                 140                 

Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala 
145                 150                 155                 160 

Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val 
                165                 170                 175     

Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val 
            180                 185                 190         

Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu 
        195                 200                 205             

Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser 
    210                 215                 220                 

Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly 
225                 230                 235                 240 

Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met 
                245                 250                 255     

Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Asn Asn Gly Phe Asn Leu 
            260                 265                 270         

Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp 
        275                 280                 285             

Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val 
    290                 295                 300                 

Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His 
305                 310                 315                 320 

Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln 
                325                 330                 335     

Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val 
            340                 345                 350         

Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly 
        355                 360                 365             

Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly 
    370                 375                 380                 

Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr 
385                 390                 395                 400 

Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn 
                405                 410                 415     

Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val 
            420                 425                 430         

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg 
        435                 440                 445             

Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr 
    450                 455                 460                 

Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala 
465                 470                 475                 480 

Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn 
                485                 490                 495     

Ala Ala Asp Lys Gln Asp Ala Gln Ala Leu Val Asp Gln Ala Gln Gln 
            500                 505                 510         

Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val 
        515                 520                 525             

Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln 
    530                 535                 540                 

Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile 
545                 550                 555                 560 

Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val 
                565                 570                 575     

Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val 
            580                 585                 590         

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Ile Pro 
        595                 600                 605             

Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala Val Ala Gly Ala Ala 
    610                 615                 620                 

Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu 
625                 630                 635                 640 

Asp Gln Leu Ala 
                

<210>   92
<211>   654
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   92
Met Lys Ser Ile Asn Lys Phe Leu Thr Ile Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Val Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Glu Gln 
            20                  25                  30          

Lys Thr Lys Thr Leu Thr Val His Lys Leu Leu Met Thr Asp Gln Glu 
        35                  40                  45              

Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr Thr Ala Gly Tyr Asp Gly 
    50                  55                  60                  

Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu Gln Gly Val Pro Gln Gly 
65                  70                  75                  80  

Val Thr Glu Ile Ser Gly Val Ala Phe Glu Leu Gln Ser Tyr Thr Gly 
                85                  90                  95      

Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr Asn Asp Ala Val Trp Thr 
            100                 105                 110         

Ala Val Asn Lys Gly Val Thr Thr Glu Thr Gly Val Lys Phe Asp Thr 
        115                 120                 125             

Glu Val Leu Gln Gly Thr Tyr Arg Leu Val Glu Val Arg Lys Glu Ser 
    130                 135                 140                 

Thr Tyr Val Gly Pro Asn Gly Lys Val Leu Thr Gly Met Lys Ala Val 
145                 150                 155                 160 

Pro Ala Leu Ile Ile Leu Pro Leu Val Asn Gln Asn Gly Val Val Glu 
                165                 170                 175     

Asn Ala His Val Tyr Pro Lys Asn Ser Glu Asp Lys Pro Thr Ala Thr 
            180                 185                 190         

Lys Thr Phe Asp Thr Ala Ala Gly Phe Val Asp Pro Gly Glu Lys Gly 
        195                 200                 205             

Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile Val Thr Thr Thr Ile Pro 
    210                 215                 220                 

Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp Ser Asp Glu Met Thr Glu 
225                 230                 235                 240 

Gly Leu Asp Tyr Asn Gly Asp Val Val Val Asn Tyr Asn Gly Gln Pro 
                245                 250                 255     

Leu Asp Asn Ser His Tyr Thr Leu Glu Ala Gly His Asn Gly Phe Ile 
            260                 265                 270         

Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala Ile Asn Gly Lys Asp Ala 
        275                 280                 285             

Glu Ala Thr Ile Ala Leu Lys Tyr Thr Ala Thr Leu Asn Ala Leu Ala 
    290                 295                 300                 

Val Ala Asp Val Pro Glu Ala Asn Asp Val Thr Phe His Tyr Gly Asn 
305                 310                 315                 320 

Asn Pro Gly His Gly Asn Thr Pro Lys Pro Asn Lys Pro Lys Asn Gly 
                325                 330                 335     

Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp Ala Lys Asp Ala Pro Ile 
            340                 345                 350         

Ala Gly Val Glu Val Thr Phe Asp Leu Val Asn Ala Gln Thr Gly Glu 
        355                 360                 365             

Val Val Lys Val Pro Gly His Glu Thr Gly Ile Val Leu Asn Gln Thr 
    370                 375                 380                 

Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu Asp Asn Asn Thr Glu Tyr 
385                 390                 395                 400 

Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Thr 
                405                 410                 415     

Ile Thr Glu Thr Gly Lys Ile Ala Val Lys Asn Trp Lys Asp Glu Asn 
            420                 425                 430         

Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly Lys 
        435                 440                 445             

Lys Phe Val Lys Val Asp Gln Lys Asp Glu Arg Leu Lys Glu Ala Gln 
    450                 455                 460                 

Phe Val Val Lys Asn Glu Gln Gly Lys Tyr Leu Ala Leu Lys Ser Ala 
465                 470                 475                 480 

Ala Gln Gln Ala Val Asn Glu Lys Ala Ala Ala Glu Ala Lys Gln Ala 
                485                 490                 495     

Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala Ala Asp Lys Asn Ala 
            500                 505                 510         

Ala Gln Ala Val Val Asp Ala Ala Gln Lys Thr Tyr Asn Asp Asn Tyr 
        515                 520                 525             

Arg Ala Ala Arg Phe Gly Tyr Val Glu Val Glu Arg Lys Glu Asp Ala 
    530                 535                 540                 

Leu Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser Gly Leu 
545                 550                 555                 560 

Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr Lys Ala Pro Glu Gly Phe 
                565                 570                 575     

Ala Lys Leu Gly Asp Val Lys Phe Glu Val Gly Ala Gly Ser Trp Asn 
            580                 585                 590         

Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp Ala Thr 
        595                 600                 605             

Lys Val Val Asn Lys Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly 
    610                 615                 620                 

Thr Ile Ile Phe Ala Val Ala Gly Ala Val Ile Met Gly Ile Ala Val 
625                 630                 635                 640 

Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu Asp Gln Leu Ala 
                645                 650                 

<210>   93
<211>   654
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   93
Met Lys Ser Ile Asn Lys Phe Leu Thr Ile Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Val Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Glu Gln 
            20                  25                  30          

Lys Thr Lys Thr Leu Thr Val His Lys Leu Leu Met Thr Asp Gln Glu 
        35                  40                  45              

Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr Thr Ala Gly Tyr Asp Gly 
    50                  55                  60                  

Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu Gln Gly Val Pro Gln Gly 
65                  70                  75                  80  

Val Thr Glu Ile Ser Gly Val Ala Phe Glu Leu Gln Ser Tyr Thr Gly 
                85                  90                  95      

Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr Asn Asp Ala Val Trp Thr 
            100                 105                 110         

Ala Val Asn Lys Gly Val Thr Thr Glu Thr Gly Val Lys Phe Asp Thr 
        115                 120                 125             

Glu Val Leu Gln Gly Thr Tyr Arg Leu Val Glu Val Arg Lys Glu Ser 
    130                 135                 140                 

Thr Tyr Val Gly Pro Asn Gly Lys Val Leu Thr Gly Met Lys Ala Val 
145                 150                 155                 160 

Pro Ala Leu Ile Ile Leu Pro Leu Val Asn Gln Asn Gly Val Val Glu 
                165                 170                 175     

Asn Ala His Val Tyr Pro Lys Asn Ser Glu Asp Lys Pro Thr Ala Thr 
            180                 185                 190         

Lys Thr Phe Asp Thr Ala Ala Gly Phe Val Asp Pro Gly Glu Lys Gly 
        195                 200                 205             

Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile Val Thr Thr Thr Ile Pro 
    210                 215                 220                 

Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp Ser Asp Glu Met Thr Glu 
225                 230                 235                 240 

Gly Leu Asp Tyr Asn Gly Asp Val Val Val Asn Tyr Asn Gly Gln Pro 
                245                 250                 255     

Leu Asp Asn Ser His Tyr Thr Leu Lys Ala Gly His Asn Gly Phe Ile 
            260                 265                 270         

Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala Ile Asn Gly Lys Asp Ala 
        275                 280                 285             

Glu Ala Thr Ile Thr Leu Lys Tyr Thr Ala Thr Leu Asn Ala Leu Ala 
    290                 295                 300                 

Val Ala Asp Val Pro Lys Ala Asn Asp Val Thr Phe His Tyr Gly Asn 
305                 310                 315                 320 

Asn Pro Gly His Gly Asn Thr Pro Lys Pro Asn Lys Pro Lys Asn Gly 
                325                 330                 335     

Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp Ala Lys Asp Ala Pro Ile 
            340                 345                 350         

Ala Gly Val Glu Val Thr Phe Asp Leu Val Asn Ala Gln Thr Gly Glu 
        355                 360                 365             

Val Val Lys Val Pro Gly His Glu Thr Gly Ile Val Leu Asn Gln Thr 
    370                 375                 380                 

Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu Asp Asn Asn Thr Glu Tyr 
385                 390                 395                 400 

Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Thr 
                405                 410                 415     

Ile Thr Glu Thr Gly Lys Ile Ala Val Lys Asn Trp Lys Asp Glu Asn 
            420                 425                 430         

Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly Lys 
        435                 440                 445             

Lys Phe Val Lys Val Asp Gln Lys Asp Glu Arg Leu Lys Glu Ala Gln 
    450                 455                 460                 

Phe Val Val Lys Asn Glu Gln Gly Lys Tyr Leu Ala Leu Lys Ser Ala 
465                 470                 475                 480 

Ala Gln Gln Ala Val Asn Glu Lys Ala Ala Ala Glu Ala Lys Gln Ala 
                485                 490                 495     

Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala Ala Asp Lys Asn Ala 
            500                 505                 510         

Ala Gln Ala Val Val Asp Ala Ala Gln Lys Thr Tyr Asn Asp Asn Tyr 
        515                 520                 525             

Arg Ala Ala Arg Phe Gly Tyr Val Glu Val Glu Arg Lys Glu Asp Ala 
    530                 535                 540                 

Leu Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser Gly Leu 
545                 550                 555                 560 

Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr Lys Ala Pro Glu Gly Phe 
                565                 570                 575     

Ala Lys Leu Gly Asp Val Lys Phe Glu Val Gly Ala Gly Ser Trp Asn 
            580                 585                 590         

Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp Ala Thr 
        595                 600                 605             

Lys Val Val Asn Lys Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly 
    610                 615                 620                 

Thr Ile Ile Phe Ala Val Ala Gly Ala Val Ile Met Gly Ile Ala Val 
625                 630                 635                 640 

Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu Asp Gln Leu Ala 
                645                 650                 

<210>   94
<211>   644
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   94
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Asp Asn 
            20                  25                  30          

Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys 
        35                  40                  45              

Leu Leu Leu Ser Glu Asp Asp Leu Glu Thr Trp Asp Thr Asn Gly Pro 
    50                  55                  60                  

Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val 
65                  70                  75                  80  

Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn 
                85                  90                  95      

Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp 
            100                 105                 110         

Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu 
        115                 120                 125             

Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys 
    130                 135                 140                 

Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala 
145                 150                 155                 160 

Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val 
                165                 170                 175     

Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val 
            180                 185                 190         

Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu 
        195                 200                 205             

Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser 
    210                 215                 220                 

Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly 
225                 230                 235                 240 

Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met 
                245                 250                 255     

Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Ile Asn Gly Phe Asn Leu 
            260                 265                 270         

Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp 
        275                 280                 285             

Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val 
    290                 295                 300                 

Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His 
305                 310                 315                 320 

Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln 
                325                 330                 335     

Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val 
            340                 345                 350         

Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Cys 
        355                 360                 365             

Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly 
    370                 375                 380                 

Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr 
385                 390                 395                 400 

Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn 
                405                 410                 415     

Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val 
            420                 425                 430         

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg 
        435                 440                 445             

Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr 
    450                 455                 460                 

Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala 
465                 470                 475                 480 

Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn 
                485                 490                 495     

Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln 
            500                 505                 510         

Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val 
        515                 520                 525             

Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln 
    530                 535                 540                 

Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile 
545                 550                 555                 560 

Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val 
                565                 570                 575     

Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val 
            580                 585                 590         

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Ile Pro 
        595                 600                 605             

Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala Val Ala Gly Ala Ala 
    610                 615                 620                 

Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu 
625                 630                 635                 640 

Asp Gln Leu Ala 
                

<210>   95
<211>   654
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   95
Met Lys Ser Ile Asn Lys Phe Leu Thr Ile Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Val Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Glu Gln 
            20                  25                  30          

Lys Thr Lys Thr Leu Thr Val His Lys Leu Leu Met Thr Asp Gln Glu 
        35                  40                  45              

Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr Thr Ala Gly Tyr Asp Gly 
    50                  55                  60                  

Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu Gln Gly Val Pro Gln Gly 
65                  70                  75                  80  

Val Thr Glu Ile Ser Gly Val Ala Phe Glu Leu Gln Ser Tyr Thr Gly 
                85                  90                  95      

Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr Asn Asp Ala Val Trp Thr 
            100                 105                 110         

Ala Val Asn Lys Gly Val Thr Thr Glu Thr Gly Val Lys Phe Asp Thr 
        115                 120                 125             

Glu Val Leu Gln Gly Thr Tyr Arg Leu Val Glu Val Arg Lys Glu Ser 
    130                 135                 140                 

Thr Tyr Val Gly Pro Asn Gly Lys Val Leu Thr Gly Met Lys Ala Val 
145                 150                 155                 160 

Pro Ala Leu Ile Thr Leu Pro Leu Val Asn Gln Asn Gly Val Val Glu 
                165                 170                 175     

Asn Ala His Val Tyr Pro Lys Asn Ser Glu Asp Lys Pro Thr Ala Thr 
            180                 185                 190         

Lys Thr Phe Asp Thr Ala Ala Gly Phe Val Asp Pro Gly Glu Lys Gly 
        195                 200                 205             

Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile Val Thr Thr Thr Ile Pro 
    210                 215                 220                 

Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp Ser Asp Glu Met Thr Glu 
225                 230                 235                 240 

Gly Leu Asp Tyr Asn Gly Asp Val Val Val Asn Tyr Asn Gly Gln Pro 
                245                 250                 255     

Leu Asp Asn Ser His Tyr Thr Leu Glu Ala Gly His Asn Gly Phe Ile 
            260                 265                 270         

Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala Ile Asn Gly Lys Asp Ala 
        275                 280                 285             

Lys Ala Thr Ile Thr Leu Lys Tyr Thr Ala Thr Leu Asn Ala Leu Ala 
    290                 295                 300                 

Val Ala Asp Val Pro Glu Ala Asn Asp Val Thr Phe His Tyr Gly Asn 
305                 310                 315                 320 

Asn Pro Gly His Gly Asn Thr Pro Lys Pro Asn Lys Pro Lys Asn Gly 
                325                 330                 335     

Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp Ala Lys Asp Ala Pro Ile 
            340                 345                 350         

Ala Gly Val Glu Val Thr Phe Asp Leu Val Asn Ala Gln Thr Gly Glu 
        355                 360                 365             

Val Val Lys Val Pro Gly His Glu Thr Gly Ile Val Leu Asn Gln Thr 
    370                 375                 380                 

Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu Asp Asn Asn Thr Glu Tyr 
385                 390                 395                 400 

Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Thr 
                405                 410                 415     

Ile Thr Glu Thr Gly Lys Ile Ala Val Lys Asn Trp Lys Asp Glu Asn 
            420                 425                 430         

Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly Lys 
        435                 440                 445             

Lys Phe Val Lys Val Asp Gln Lys Asp Glu Arg Leu Lys Glu Ala Gln 
    450                 455                 460                 

Phe Val Val Lys Asn Glu Gln Gly Lys Tyr Leu Ala Leu Lys Ser Ala 
465                 470                 475                 480 

Ala Gln Gln Ala Val Asn Glu Lys Ala Ala Ala Glu Ala Lys Gln Ala 
                485                 490                 495     

Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala Ala Asp Lys Asn Ala 
            500                 505                 510         

Ala Gln Ala Val Val Asp Ala Ala Gln Lys Thr Tyr Asn Asp Asn Tyr 
        515                 520                 525             

Arg Ala Ala Arg Phe Gly Tyr Val Glu Val Glu Arg Lys Glu Asp Ala 
    530                 535                 540                 

Leu Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser Gly Leu 
545                 550                 555                 560 

Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr Lys Ala Pro Glu Gly Phe 
                565                 570                 575     

Ala Lys Leu Gly Asp Val Lys Phe Glu Val Gly Ala Gly Ser Trp Asn 
            580                 585                 590         

Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp Ala Thr 
        595                 600                 605             

Lys Val Val Asn Lys Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly 
    610                 615                 620                 

Thr Ile Ile Phe Ala Val Ala Gly Ala Val Ile Met Gly Ile Ala Val 
625                 630                 635                 640 

Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu Asp Gln Leu Ala 
                645                 650                 

<210>   96
<211>   644
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   96
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Asp Asn 
            20                  25                  30          

Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys 
        35                  40                  45              

Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro 
    50                  55                  60                  

Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val 
65                  70                  75                  80  

Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn 
                85                  90                  95      

Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp 
            100                 105                 110         

Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu 
        115                 120                 125             

Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys 
    130                 135                 140                 

Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala 
145                 150                 155                 160 

Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val 
                165                 170                 175     

Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val 
            180                 185                 190         

Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu 
        195                 200                 205             

Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser 
    210                 215                 220                 

Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly 
225                 230                 235                 240 

Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met 
                245                 250                 255     

Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Ile Asn Gly Phe Asn Leu 
            260                 265                 270         

Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp 
        275                 280                 285             

Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val 
    290                 295                 300                 

Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His 
305                 310                 315                 320 

Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln 
                325                 330                 335     

Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val 
            340                 345                 350         

Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly 
        355                 360                 365             

Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly 
    370                 375                 380                 

Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr 
385                 390                 395                 400 

Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn 
                405                 410                 415     

Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Leu Glu Glu Pro Arg Val 
            420                 425                 430         

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg 
        435                 440                 445             

Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr 
    450                 455                 460                 

Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala 
465                 470                 475                 480 

Ala Ser Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn 
                485                 490                 495     

Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln 
            500                 505                 510         

Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val 
        515                 520                 525             

Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln 
    530                 535                 540                 

Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile 
545                 550                 555                 560 

Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val 
                565                 570                 575     

Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val 
            580                 585                 590         

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Ile Pro 
        595                 600                 605             

Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala Val Ala Gly Ala Ala 
    610                 615                 620                 

Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu 
625                 630                 635                 640 

Asp Gln Leu Ala 
                

<210>   97
<211>   251
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   fragment of spr2021 (SP2216-1)

<400>   97
Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp Asn Lys Ile Ser Asn 
1               5                   10                  15      

Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln Val Asp Gln Ile Gln 
            20                  25                  30          

Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser Asn Leu Gln Ala Glu 
        35                  40                  45              

Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu Glu Gly Glu Ile Thr 
    50                  55                  60                  

Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln Ser Leu Glu Lys Gln 
65                  70                  75                  80  

Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr Ser Tyr Ile Asn Thr 
                85                  90                  95      

Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile Ser Arg Val Ala Ala 
            100                 105                 110         

Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met Leu Glu Gln Gln Lys 
        115                 120                 125             

Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val Ala Asn Asn Asp Ala 
    130                 135                 140                 

Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu Ala Asp Asp Ala Gln 
145                 150                 155                 160 

Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala Ala Glu Leu Ser Leu 
                165                 170                 175     

Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys Ala Ser Leu Leu Glu 
            180                 185                 190         

Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala Ala Ala Val Ala Glu 
        195                 200                 205             

Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln Gln Ser Val Leu Ala 
    210                 215                 220                 

Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln Ala Val Ser Glu Ser 
225                 230                 235                 240 

Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro 
                245                 250     

<210>   98
<211>   315
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   SP 1732-3

<400>   98
Tyr Leu Ile Leu Leu Ala Ser Leu Val Leu Val Ala Ala Ser Leu Ile 
1               5                   10                  15      

Trp Ile Leu Ser Arg Thr Pro Ala Thr Ile Ala Ile Pro Asp Val Ala 
            20                  25                  30          

Gly Gln Thr Val Ala Glu Ala Lys Ala Thr Leu Lys Lys Ala Asn Phe 
        35                  40                  45              

Glu Ile Gly Glu Glu Lys Thr Glu Ala Ser Glu Lys Val Glu Glu Gly 
    50                  55                  60                  

Arg Ile Ile Arg Thr Asp Pro Gly Ala Gly Thr Gly Arg Lys Glu Gly 
65                  70                  75                  80  

Thr Lys Ile Asn Leu Val Val Ser Ser Gly Lys Gln Ser Phe Gln Ile 
                85                  90                  95      

Ser Asn Tyr Val Gly Arg Lys Ser Ser Asp Val Ile Ala Glu Leu Lys 
            100                 105                 110         

Glu Lys Lys Val Pro Asp Asn Leu Ile Lys Ile Glu Glu Glu Glu Ser 
        115                 120                 125             

Asn Glu Ser Glu Ala Gly Thr Val Leu Lys Gln Ser Leu Pro Glu Gly 
    130                 135                 140                 

Thr Thr Tyr Asp Leu Ser Lys Ala Thr Gln Ile Val Leu Thr Val Ala 
145                 150                 155                 160 

Lys Lys Ala Thr Thr Ile Gln Leu Gly Asn Tyr Ile Gly Arg Asn Ser 
                165                 170                 175     

Thr Glu Val Ile Ser Glu Leu Lys Gln Lys Lys Val Pro Glu Asn Leu 
            180                 185                 190         

Ile Lys Ile Glu Glu Glu Glu Ser Ser Glu Ser Glu Pro Gly Thr Ile 
        195                 200                 205             

Met Lys Gln Ser Pro Gly Ala Gly Thr Thr Tyr Asp Val Ser Lys Pro 
    210                 215                 220                 

Thr Gln Ile Val Leu Thr Val Ala Lys Lys Val Thr Ser Val Ala Met 
225                 230                 235                 240 

Pro Ser Tyr Ile Gly Ser Ser Leu Glu Phe Thr Lys Asn Asn Leu Ile 
                245                 250                 255     

Gln Ile Val Gly Ile Lys Glu Ala Asn Ile Glu Val Val Glu Val Thr 
            260                 265                 270         

Thr Ala Pro Ala Gly Ser Val Glu Gly Met Val Val Glu Gln Ser Pro 
        275                 280                 285             

Arg Ala Gly Glu Lys Val Asp Leu Asn Lys Thr Arg Val Lys Ile Ser 
    290                 295                 300                 

Ile Tyr Lys Pro Lys Thr Thr Ser Ala Thr Pro 
305                 310                 315 

<210>   99
<211>   289
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PsaA fragment

<400>   99
Ala Ser Gly Lys Lys Asp Thr Thr Ser Gly Gln Lys Leu Lys Val Val 
1               5                   10                  15      

Ala Thr Asn Ser Ile Ile Ala Asp Ile Thr Lys Asn Ile Ala Gly Asp 
            20                  25                  30          

Lys Ile Asp Leu His Ser Ile Val Pro Ile Gly Gln Asp Pro His Glu 
        35                  40                  45              

Tyr Glu Pro Leu Pro Glu Asp Val Lys Lys Thr Ser Glu Ala Asp Leu 
    50                  55                  60                  

Ile Phe Tyr Asn Gly Ile Asn Leu Glu Thr Gly Gly Asn Ala Trp Phe 
65                  70                  75                  80  

Thr Lys Leu Val Glu Asn Ala Lys Lys Thr Glu Asn Lys Asp Tyr Phe 
                85                  90                  95      

Ala Val Ser Asp Gly Val Asp Val Ile Tyr Leu Glu Gly Gln Asn Glu 
            100                 105                 110         

Lys Gly Lys Glu Asp Pro His Ala Trp Leu Asn Leu Glu Asn Gly Ile 
        115                 120                 125             

Ile Phe Ala Lys Asn Ile Ala Lys Gln Leu Ser Ala Lys Asp Pro Asn 
    130                 135                 140                 

Asn Lys Glu Phe Tyr Glu Lys Asn Leu Lys Glu Tyr Thr Asp Lys Leu 
145                 150                 155                 160 

Asp Lys Leu Asp Lys Glu Ser Lys Asp Lys Phe Asn Lys Ile Pro Ala 
                165                 170                 175     

Glu Lys Lys Leu Ile Val Thr Ser Glu Gly Ala Phe Lys Tyr Phe Ser 
            180                 185                 190         

Lys Ala Tyr Gly Val Pro Ser Ala Tyr Ile Trp Glu Ile Asn Thr Glu 
        195                 200                 205             

Glu Glu Gly Thr Pro Glu Gln Ile Lys Thr Leu Val Glu Lys Leu Arg 
    210                 215                 220                 

Gln Thr Lys Val Pro Ser Leu Phe Val Glu Ser Ser Val Asp Asp Arg 
225                 230                 235                 240 

Pro Met Lys Thr Val Ser Gln Asp Thr Asn Ile Pro Ile Tyr Ala Gln 
                245                 250                 255     

Ile Phe Thr Asp Ser Ile Ala Glu Gln Gly Lys Glu Gly Asp Ser Tyr 
            260                 265                 270         

Tyr Ser Met Met Lys Tyr Asn Leu Asp Lys Ile Ala Glu Gly Leu Ala 
        275                 280                 285             

Lys 
    

<210>   100
<211>   20
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB Clade I D1 Epitope

<400>   100
His Lys Leu Leu Ala Thr Asp Gly Asp Met Asp Lys Ile Ala Asn Glu 
1               5                   10                  15      

Leu Glu Thr Gly 
            20  

<210>   101
<211>   15
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB Clade I D4 Epitope

<400>   101
Val Thr Thr Lys Asp Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn 
1               5                   10                  15  

<210>   102
<211>   20
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB Clade II D1 Epitope

<400>   102
Val Thr Lys Thr Leu Thr Ile His Lys Leu Leu Leu Ser Glu Asp Asp 
1               5                   10                  15      

Leu Lys Thr Trp 
            20  

<210>   103
<211>   15
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB Clade II D4 Epitope

<400>   103
Tyr Thr Asn Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp 
1               5                   10                  15  

<210>   104
<211>   20
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB Clade III D1 Epitope

<400>   104
His Lys Leu Leu Met Thr Asp Gln Glu Leu Asp Ala Trp Asn Ser Asp 
1               5                   10                  15      

Ala Ile Thr Thr 
            20  

<210>   105
<211>   15
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB Clade III D4 Epitope

<400>   105
Lys Gln Ala Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala Ala 
1               5                   10                  15  
  
