                         SEQUENCE LISTING

<110>  Fundacin Centro Nacional de Investigaciones 
       Cardiovasculares Carlos III
 
<120>  USO DE INHIBIDORES DE EMMPRIN PARA EL TRATAMIENTO DE DAOS 
       CARDIACOS TRAS ISQUEMIA/ REPERFUSIN

<130>  P6049PC00

<150>  ES P201031794
<151>  2010-12-02

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp 
            20                  25                  30          


Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr 
        35                  40                  45              


Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu 
    50                  55                  60                  


Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp 
65                  70                  75                  80  


Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr 
                85                  90                  95      


Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser 
            100                 105                 110         


Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser 
        115                 120                 125             


Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp 
    130                 135                 140                 


Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 
145                 150                 155                 160 


Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 
                165                 170                 175     


Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly 
            180                 185                 190         


Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala 
        195                 200                 205             


Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr 
    210                 215                 220                 


Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 
225                 230                 235                 240 


Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 
                245                 250                 255     


Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
            260                 265                 


<210>  2
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anticuerpo anti-EMMPRIN

<400>  2

Ala Gly Phe Val Gln Ala Pro Leu Ser Gln Gln Arg Trp Val Gly Gly 
1               5                   10                  15      


Ser Val Glu Leu His Cys Glu Ala Val Gly Ser Pro Val Pro Glu Ile 
            20                  25                  30          


Gln Trp Trp Phe Glu Gly Gln Gly Pro Asn Asp Thr Cys Ser Gln Leu 
        35                  40                  45              


Trp Asp Gly Ala Arg Leu Asp Arg Val His Ile His Ala Thr Tyr His 
    50                  55                  60                  


Gln His Ala Ala Ser Thr Ile Ser Ile Asp Thr Leu Val Glu Glu Asp 
65                  70                  75                  80  


Thr Gly Thr Tyr Glu Cys Arg Ala Ser Asn Asp Pro Asp Arg Asn His 
                85                  90                  95      


Leu Thr Arg Ala Pro Arg Val Lys Trp Val Arg Ala Gln Ala Val Val 
            100                 105                 110         


Leu Val Leu Glu Pro Gly Thr 
        115                 


<210>  3
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pptido AP-9

<400>  3

Tyr Lys Leu Pro Gly His His His His Tyr Arg Pro 
1               5                   10          


<210>  4
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  4
aagaccttgg ctccaagata ccctgtctc                                         29


<210>  5
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  5
aagtatcttg gagccaaggt ccctgtctc                                         29


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  6
guucuucgug aguuccuctt                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  7
ttcaagaagc acucaaggag                                                   20


<210>  8
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  8
gguucuucgu gaguuccuct t                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  9
gaggaacuca cgaagaacct g                                                 21


<210>  10
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  10
guaggaccgg cgaggaaua                                                    19


<210>  11
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  11
gaccuuggcu ccaagauac                                                    19


<210>  12
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  12
gucgucagaa cacaucaac                                                    19


<210>  13
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  13
gaucacugac ucugaggac                                                    19


<210>  14
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  14
ugacaaaggc aagaacguc                                                    19


<210>  15
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  15
guuggguuuu cuccauuca                                                    19


<210>  16
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  16
gggaaugcuc caaacgacat t                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  17
ugucguuugg agcauuccct t                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  18
ggaucaaggu cggaaagaat t                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  19
uuuuuuccga ccuugaucct t                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  20
gagccuuacc uuacagaaat t                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  21
uuucuguaag guaaggcuct t                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  22
gcagugaccc agaccgcaat t                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA anti-EMMPRIN

<400>  23
uugcggucug ggucacugct t                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucletido antisentido anti-EMMPRIN

<400>  24
gagctacaca ttgagaacct g                                                 21


<210>  25
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Enzimas de ADN anti-EMMPRIN

<400>  25
tgattcctag gctagctaca acgatcctcg ccg                                    33


<210>  26
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Enzimas de ADN anti-EMMPRIN

<400>  26
cagcgcgaag gctagctaca acgacccagc agc                                    33


<210>  27
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Enzimas de ADN anti-EMMPRIN

<400>  27
tgaggagtag gctagctaca acgacttgga gcc                                    33


<210>  28
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Enzimas de ADN anti-EMMPRIN

<400>  28
tgatcaccag gctagctaca acgagccccc ctt                                    33


<210>  29
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Enzimas de ADN anti-EMMPRIN

<400>  29
ggagctggag gctagctaca acgagttggc cgt                                    33


<210>  30
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Enzimas de ADN anti-EMMPRIN

<400>  30
cctcgttgag gctagctaca acgagtgttc tga                                    33


<210>  31
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Enzimas de ADN anti-EMMPRIN

<400>  31
agtcagtgag gctagctaca acgacttgta cca                                    33


<210>  32
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Enzimas de ADN anti-EMMPRIN

<400>  32
cggcctccag gctagctaca acgagttcag gtt                                    33


<210>  33
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Enzimas de ADN anti-EMMPRIN

<400>  33
ggagcgtgag gctagctaca acgagatggc ctg                                    33


<210>  34
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Enzimas de ADN anti-EMMPRIN

<400>  34
gcaccagcag gctagctaca acgactcagc cac                                    33


<210>  35
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Enzimas de ADN anti-EMMPRIN

<400>  35
cctttgtcag gctagctaca acgatctggt gct                                    33


<210>  36
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  cebador directo utilizado para la clonacin de la regin 
       reguladora de EMMPRIN

<400>  36
cggggtacca gcactccatc caaaggcaga                                        30


<210>  37
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  cebador inverso utilizado para la clonacin de la regin 
       reguladora de EMMPRIN

<400>  37
ggaagatctg tcgcctcgtc caggagc                                           27


<210>  38
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  cebador directo utilizado para la mutagnesis del promotor de 
       EMMPRIN

<400>  38
ggggttagaa gccttctcta cagtgcacga ccttcaaa                               38


<210>  39
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  cebador inverso utilizado para la mutagnesis del promotor de 
       EMMPRIN

<400>  39
tttgaaggtc gtgcactgta gagaaggctt ctaacccc                               38


